intracranial hemorrhages

Summary

Summary: Bleeding within the intracranial cavity, including hemorrhages in the brain and within the cranial epidural, subdural, and subarachnoid spaces.

Top Publications

  1. ncbi Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke
    Joan Montaner
    Cerebrovascular Unit, Vall d Hebron Hospital, Barcelona, Spain
    Circulation 107:598-603. 2003
  2. ncbi Clinical and neuroradiological predictors of mortality in patients with primary pontine hemorrhage
    Kemal Balci
    Department of Neurology, School of Medicine, Trakya University, Edirne, Turkey
    Clin Neurol Neurosurg 108:36-9. 2005
  3. pmc Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke
    Alex K Harris
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, USA
    BMC Neurosci 6:49. 2005
  4. ncbi Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    A Furlan
    Cerebrovascular Center, Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
    JAMA 282:2003-11. 1999
  5. ncbi Rates and implications for hospitalization of patients ≥65 years of age with atrial fibrillation/flutter
    Gerald V Naccarelli
    Penn State Heart and Vascular Institute, Milton S Hershey Medical Center, Penn State University, Hershey, Pennsylvania, USA
    Am J Cardiol 109:543-9. 2012
  6. ncbi Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants
    B Schmidt
    Department of Pediatrics, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 344:1966-72. 2001
  7. ncbi Clinical spectrum of type IV collagen (COL4A1) mutations: a novel genetic multisystem disease
    Katayoun Vahedi
    Department of Neurology, Lariboisiere Hospital, France
    Curr Opin Neurol 24:63-8. 2011
  8. ncbi Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Lancet 380:1749-58. 2012
  9. ncbi Hemorrhagic manifestations of reversible cerebral vasoconstriction syndrome: frequency, features, and risk factors
    Anne Ducros
    Emergency Headache Center Head and Neck Clinic, Lariboisiere Hospital, Paris, France
    Stroke 41:2505-11. 2010
  10. ncbi Neuroendoscopic removal of intraventricular hemorrhage combined with hydrocephalus
    H Hamada
    Department of Neurosurgery, Faculty of Medicine, University of Toyama, Toyama, Japan
    Minim Invasive Neurosurg 51:345-9. 2008

Detail Information

Publications227 found, 100 shown here

  1. ncbi Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke
    Joan Montaner
    Cerebrovascular Unit, Vall d Hebron Hospital, Barcelona, Spain
    Circulation 107:598-603. 2003
    ..We aimed to correlate plasmatic MMP levels with the appearance of intracranial bleeding complications in stroke patients treated with t-PA...
  2. ncbi Clinical and neuroradiological predictors of mortality in patients with primary pontine hemorrhage
    Kemal Balci
    Department of Neurology, School of Medicine, Trakya University, Edirne, Turkey
    Clin Neurol Neurosurg 108:36-9. 2005
    Primary pontine hemorrhage (PPH) accounts approximately for about 5-10% of intracranial hemorrhages, and PPHs are known to have a much less uniform prognosis...
  3. pmc Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke
    Alex K Harris
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, USA
    BMC Neurosci 6:49. 2005
    ..While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the relative contribution of neutrophils to the MMP activity and to the development of hemorrhagic transformation remains unknown...
  4. ncbi Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    A Furlan
    Cerebrovascular Center, Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
    JAMA 282:2003-11. 1999
    ..Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed...
  5. ncbi Rates and implications for hospitalization of patients ≥65 years of age with atrial fibrillation/flutter
    Gerald V Naccarelli
    Penn State Heart and Vascular Institute, Milton S Hershey Medical Center, Penn State University, Hershey, Pennsylvania, USA
    Am J Cardiol 109:543-9. 2012
    ..Measures that lower inpatient admission rates, particularly readmission rates, may reduce the increasing cost of treating patients with AF or AFL with Medicare supplemental insurance...
  6. ncbi Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants
    B Schmidt
    Department of Pediatrics, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 344:1966-72. 2001
    ..Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known...
  7. ncbi Clinical spectrum of type IV collagen (COL4A1) mutations: a novel genetic multisystem disease
    Katayoun Vahedi
    Department of Neurology, Lariboisiere Hospital, France
    Curr Opin Neurol 24:63-8. 2011
    ..COL4A1 encodes type IV collagen α1 chain, a crucial component of nearly all basement membrane including vasculature, renal glomerule and ocular structures...
  8. ncbi Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Lancet 380:1749-58. 2012
    ..We assessed in this trial's participants how results differed according to patients' CHADS(2), CHA(2)DS(2)VASc, and HAS-BLED scores, used to predict the risk of stroke and bleeding...
  9. ncbi Hemorrhagic manifestations of reversible cerebral vasoconstriction syndrome: frequency, features, and risk factors
    Anne Ducros
    Emergency Headache Center Head and Neck Clinic, Lariboisiere Hospital, Paris, France
    Stroke 41:2505-11. 2010
    ..The aim of this study was to describe the frequency, patterns, and risk factors of intracranial hemorrhages in RCVS.
  10. ncbi Neuroendoscopic removal of intraventricular hemorrhage combined with hydrocephalus
    H Hamada
    Department of Neurosurgery, Faculty of Medicine, University of Toyama, Toyama, Japan
    Minim Invasive Neurosurg 51:345-9. 2008
    ..Hydrocephalus associated with intraventricular hemorrhage (IVH) is a good indication for neuroendoscopic surgery. We describe herein our experiences with 17 cases of IVH combined with hydrocephalus treated using a neuroendoscope...
  11. ncbi Neonatal complications of vacuum-assisted delivery
    Colin Simonson
    Department of Obstetrics and Gynaecology, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Buxelles, Brussels, Belgium
    Obstet Gynecol 109:626-33. 2007
    ....
  12. ncbi Rothia dentocariosa endocarditis complicated by multiple intracranial hemorrhages
    J C Ricaurte
    Department of Medicine, Saint Vincent's Hospital and Medical Center of New York, NY 10011, USA
    South Med J 94:438-40. 2001
    ..Solitary intracranial hemorrhages have been reported in two cases...
  13. ncbi Image and diagnosis. Intracranial haemorrhage due to vitamin K deficiency, as the first symptom of extrahepatic biliary atresia
    V Ertekin
    Faculty of Medicine, Department of Pediatric Gastroenterology, Ataturk University, Erzurum, Turkey
    West Indian Med J 54:392, 397. 2005
  14. ncbi Application of neuroendoscopy in the treatment of intraventricular hemorrhage
    Zaiqiang Zhang
    Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, PR China
    Cerebrovasc Dis 24:91-6. 2007
    ..The objective of this article is to compare different surgical procedures in order to evaluate a method of minimally invasive treatment for intraventricular hemorrhage...
  15. ncbi In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Box 63, Boston, Mass 02111, USA
    Stroke 35:1141-6. 2004
    In patients with acute ischemic stroke, intracranial hemorrhages are categorized as symptomatic or asymptomatic based on the presence or absence of a clinically detectable neurological deterioration...
  16. ncbi Do we really need 24-h observation for patients with minimal brain injury and small intracranial bleeding? The Bernese Trauma Unit Protocol
    Benoit Schaller
    Department of Emergency Medicine, Inselspital, Bern, Switzerland
    Emerg Med J 27:537-9. 2010
    ..However, optimal diagnosis and treatment protocols remain controversial. The aim of this study is to assess whether a specific group of patients can be discharged from the hospital without 24-h neurological observation...
  17. ncbi Prediction of fatal intracranial hemorrhage in patients with acute myeloid leukemia
    C Y Chen
    Department of Internal Medicine, Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan
    Ann Oncol 20:1100-4. 2009
    ..Intracranial hemorrhage (ICH) is the second leading cause of mortality in patients with acute myeloid leukemia (AML). However, the prognostic factors for ICH in AML patients are still under investigation...
  18. ncbi Statin use and functional outcome after tissue plasminogen activator treatment in acute ischaemic stroke
    I Miedema
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Cerebrovasc Dis 29:263-7. 2010
    ..This study investigated whether patients on prior statin therapy and treated with tissue plasminogen activator (tPA) for acute ischaemic stroke have a better functional outcome than statin-naïve patients...
  19. ncbi Intracranial hemorrhage due to late hemorrhagic disease in two siblings
    Huseyin Per
    Department of Pediatric Neurology, Erciyes University Medical Faculty, Kayseri, Turkey
    J Emerg Med 31:49-52. 2006
    ..In this study, we report on two siblings with intracranial bleeding who were fully breastfed without a routine supplementation of vitamin K. Vitamin K should be given to all newborns as a single, intramuscular dose of 1 mg...
  20. ncbi Intracranial hemorrhage in late hemorrhagic disease of the newborn
    Puneet A Pooni
    Department of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
    Indian Pediatr 40:243-8. 2003
    ..Three patients expired. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. Isolated intracranial hemorrhage is a common mode of presentation...
  21. ncbi Recombinant factor VIIa for warfarin-associated intracranial bleeding
    Can Ilyas
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Anesth 20:276-9. 2008
    ..To examine the efficacy of recombinant factor VIIa (rVIIa) in reversing warfarin-induced coagulopathy in trauma patients presenting with intracranial hemorrhage (ICH)...
  22. ncbi Neurodevelopmental outcome in children with posthemorrhagic hydrocephalus
    Yasuyuki Futagi
    Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho, Izumi, Osaka 594 1101, Japan
    Pediatr Neurol 33:26-32. 2005
    ....
  23. ncbi Experience of recombinant activated factor VII (NovoSeven) in the operating theatre and intensive care unit for the management of intracranial bleeding in nonhaemophilic patients
    Michael Felfernig
    Department of Anaesthesia and General Intensive Care, Medical University Vienna, Waehringerguertel 18 20, 1090 Vienna, Austria
    Clin Neurol Neurosurg 110:227-32. 2008
    ..Our aim was to explore the use of recombinant activated factor VII (rFVIIa NovoSeven Novo Nordisk, A/S, Bagsvaerd, Denmark) for the management of ICH in the operating theater and intensive care unit...
  24. ncbi Warfarin and intracranial haemorrhage
    Rebecca Appelboam
    Anaesthesia and Intensive Care Medicine, Royal Devon and Exeter Hospital, Barrack Road, Exeter, Devon, UK
    Blood Rev 23:1-9. 2009
    ..The specific management of patients with prosthetic heart valves is also discussed. A summary of current societal guidelines is also included, as are some key practice points...
  25. ncbi Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage
    William D Freeman
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla 32224, USA
    Mayo Clin Proc 79:1495-500. 2004
    ..To assess the effects of recombinant factor VIIa (rFVIIa) on hemorrhage volume and functional outcomes in warfarin-related acute intracranial hemorrhage (ICH), which has a 30-day mortality of more than 50%...
  26. pmc Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Belfer Building, Room 1306C, 1300 Morris Park Avenue, Bronx, NY, United States
    Atherosclerosis 201:130-7. 2008
    ..We assessed the association of genetic variation in MMP3 and MMP9 with risk of myocardial infarction and stroke...
  27. ncbi Intracranial hemorrhage in asymptomatic neonates: prevalence on MR images and relationship to obstetric and neonatal risk factors
    Christopher B Looney
    Department of Psychiatry, CB No 7160, 7025A Neurosciences Hospital, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Radiology 242:535-41. 2007
    ..To retrospectively evaluate the prevalence of neonatal intracranial hemorrhage (ICH) and its relationship to obstetric and neonatal risk factors...
  28. ncbi Predictors of clinical improvement, angiographic recanalization, and intracranial hemorrhage after intra-arterial thrombolysis for acute ischemic stroke
    J I Suarez
    Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    Stroke 30:2094-100. 1999
    ..We sought to evaluate predictors of clinical outcome, angiographic success, and adverse effects after intra-arterial administration of urokinase for acute ischemic stroke...
  29. ncbi The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
    Werner Hacke
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 36:66-73. 2005
    ....
  30. ncbi Phosphodiesterase 4D gene polymorphism is associated with ischaemic and haemorrhagic stroke
    Hao Xue
    Department of Cardiology, Chinese People s Liberation Army General Hospital, Beijing, PR China
    Clin Sci (Lond) 116:335-40. 2009
    ..80; 95% CI, 1.300-2.491). Our findings support that SNP83 of PDE4D is a genetic risk factor for atherothrombotic strokes in a Chinese population...
  31. pmc Intracranial bleeding in patients with traumatic brain injury: a prognostic study
    Pablo Perel
    Epidemiology and Population Health Department, London School of Hygiene and Tropical Medicine, London, UK
    BMC Emerg Med 9:15. 2009
    ..We analysed data from the Trauma Audit & Research Network (TARN), a large European trauma registry, to evaluate the association between the size of IB and mortality in patients with TBI...
  32. ncbi Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study
    Nils Wahlgren
    Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Lancet 369:275-82. 2007
    ..Under European Union regulations, SITS-MOST was required to assess the safety profile of alteplase in clinical practice by comparison with results in randomised controlled trials...
  33. pmc Migraine and risk of haemorrhagic stroke in women: prospective cohort study
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMJ 341:c3659. 2010
    ..To examine the association between migraine and migraine aura status with risk of haemorrhagic stroke...
  34. ncbi The prognostic impact of clinical and CT parameters in patients with pontine hemorrhage
    Rainer Dziewas
    Department of Neurology, University of Munster, Munster, Germany
    Cerebrovasc Dis 16:224-9. 2003
    ..In patients with pontine hemorrhage (PH), an accurate prognostic assessment is critical for establishing a reasonable therapeutic approach...
  35. ncbi Intracranial hemorrhages due to late-type vitamin K deficiency bleeding
    Melih Cekinmez
    Department of Neurosurgery, Faculty of Medicine, Baskent University, Dadaloglu Mahallesi, 01250, Yuregir, Adana, Turkey
    Childs Nerv Syst 24:821-5. 2008
    ..Late-type VKDB has particular importance due to frequent intracranial hemorrhages that lead to high mortality and morbidity...
  36. pmc Intracranial haemorrhage due to late onset vitamin K deficiency bleeding in Hanoi province, Vietnam
    N Danielsson
    Astrid Lindgren s Children s Hospital, Stockholm, Sweden
    Arch Dis Child Fetal Neonatal Ed 89:F546-50. 2004
    ..In many developing countries vitamin K prophylaxis is not routinely administered at birth. There are insufficient data to assess the cost effectiveness of its implementation in such countries...
  37. pmc Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age
    Thuy Mai Luu
    Women and Infants Hospital, Department of Pediatrics, 101 Dudley St, Providence, RI 02905, USA
    Pediatrics 123:1037-44. 2009
    ....
  38. ncbi Reliability of diagnosis of traumatic brain injury by computed tomography in the acute phase
    Jussi P Laalo
    Medical Imaging Centre, Turku University Central Hospital, Turku, Finland
    J Neurotrauma 26:2169-78. 2009
    ..Experience increased accuracy, yet even between the reports of the most experienced readers, there were marked differences...
  39. ncbi Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke
    Mar Castellanos
    Department of Neurology, Hospital Universitari Doctor Josep Trueta in affiliation with the UAB, Avda Francia s n, Girona 17007, Spain
    Stroke 35:1671-6. 2004
    ..We investigated whether high plasma levels of c-Fn were associated with hemorrhagic transformation (HT) after treatment with tissue plasminogen activator (tPA) in patients with acute stroke...
  40. ncbi Different risk factors for different stroke subtypes: association of blood pressure, cholesterol, and antioxidants
    J M Leppälä
    Department of Public Health, University of Helsinki, Finland
    Stroke 30:2535-40. 1999
    ..Blood pressure is an important risk factor for stroke, but the roles of serum total and HDL cholesterol, alpha-tocopherol, and beta-carotene are poorly established. We studied these factors in relation to stroke subtypes...
  41. pmc Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage
    David L Brody
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurocrit Care 2:263-7. 2005
    ..Current therapies are associated with significant complications and/or prolonged time to correction of coagulopathy. Recombinant factor VIIa (FVIIa) might allow faster and safer correction of coagulopathy...
  42. ncbi Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation
    Guy Rosenthal
    Department of Neurosurgery, University of California, San Francisco, CA 94117, USA
    J Neurosurg 108:575-87. 2008
    ..We studied the effects of hemoglobin-based oxygen-carrying (HBOC)-201 solution compared with lactated Ringer (LR) solution in a large animal model of brain injury and hemorrhage, in a blinded prospective randomized study...
  43. pmc Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition
    Govindaiah Vinukonda
    Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
    Brain 133:2264-80. 2010
    ....
  44. ncbi S100B protein in biological fluids: a tool for perinatal medicine
    Fabrizio Michetti
    Institute of Anatomy, Catholic University, Largo Francesco Vito 1, I 00168 Rome, Italy
    Clin Chem 48:2097-104. 2002
    ..Finally, because of the neurotrophic role putatively played by S100B, its measurement in biological fluids at pre-/perinatal ages makes it a candidate for the laboratory evaluation of brain maturation...
  45. ncbi Cause is the main predictor of outcome in patients with pontine hemorrhage
    Alejandro A Rabinstein
    Neurological Neurosurgical Intensive Care Unit, Saint Mary s Hospital, Rochester, Minn, USA
    Cerebrovasc Dis 17:66-71. 2004
    ..Pontine hemorrhages frequently lead to death or severe disability. Predictors of early mortality have been previously described but little is known about the factors influencing long-term disability...
  46. ncbi Early biomarkers of stroke
    Mark A Reynolds
    Biosite Incorporated, 11030 Roselle St, San Diego, CA 92121 Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Clin Chem 49:1733-9. 2003
    ..The ability to correlate blood-borne protein biomarkers with stroke phenotypes would aid in the development of such rapid tests...
  47. ncbi Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892 1063, USA
    J Neuroimaging 14:54-7. 2004
    Recent reports have indicated that cerebral microbleeds (CMBs) detected on gradient-echo (GRF) magnetic resonance imaging may be a risk factor for therapy related intracranial hemorrhages (ICHs).
  48. ncbi Spontaneous superficial parenchymal and leptomeningeal hemorrhage in term neonates
    Amy H Huang
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA
    AJNR Am J Neuroradiol 25:469-75. 2004
    ..In this study, we review the clinical and neuroimaging features of healthy term neonates presenting with spontaneous superficial parenchymal and leptomeningeal (ie, subpial or subarachnoid) hemorrhage...
  49. ncbi Hypertensive pontine microhemorrhage
    Jee Hyang Jeong
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Stroke 33:925-9. 2002
    ..This study investigated whether the topography of hypertensive pontine microhemorrhages (hPMHs) resembles that of larger primary pontine hemorrhages...
  50. ncbi Intracerebellar hemorrhage in premature infants: sonographic detection and outcome
    Hanna Müller
    Division of Neonatology, Department of Pediatrics, University of Heidelberg, Germany
    J Perinat Med 35:67-70. 2007
    ..Intracerebellar hemorrhage is a rarely confirmed diagnosis in preterm infants in comparison to peri-/intraventricular hemorrhage. This study evaluates the incidence of intracerebellar hemorrhage and neurological outcome in preterm infants...
  51. ncbi Migraine, headache, and the risk of stroke in women: a prospective study
    T Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Neurology 64:1020-6. 2005
    ..Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse...
  52. ncbi A review of genetic causes of ischemic and hemorrhagic stroke
    Martijn Tonk
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    J Neurol Sci 257:273-9. 2007
    ..Animal model of stroke can also provide valuable information on genetic factors involved in stroke predisposition. In this review, the focus lies on monogenic forms of stroke that can serve as models to study the more common phenotypes...
  53. ncbi Association of apolipoprotein E genotype and cerebrovascular disease risk factors in a Turkish population
    Nebahat Tasdemir
    Department of Neurology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
    Int J Neurosci 118:1109-29. 2008
    ..These results suggest that ApoE polymorphism in this population was not associated with any other demographic or clinical variables except for lipid profiles and homocysteine levels...
  54. ncbi Stroke after bone marrow transplantation: frequency, aetiology and outcome
    W M Coplin
    Division of Pulmonary and Critical Care Medicine and the Department of Neurology, University of Washington, Seattle, Washington, USA
    Brain 124:1043-51. 2001
    ..Stroke occurs relatively frequently (incidence almost 3%) after BMT, has a relatively high frequency of infection-triggered events, has a neurological outcome not easily predicted from available data and is often fatal...
  55. ncbi Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literature
    Matthew R Naunheim
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Neurol Neurosurg 112:575-7. 2010
    ..This case demonstrates that the presence of hyperleukocytosis in a patient with intracerebral hemorrhage should raise clinical suspicion for acute leukemia as the cause of the ICH...
  56. ncbi Intracranial hemorrhage in term newborns: management and outcomes
    Surya N Gupta
    Department of Pediatric Neurology, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Pediatr Neurol 40:1-12. 2009
    ....
  57. ncbi A priority treatment of the intraventricular hemorrhage (IVH) should be performed in the patients suffering intracerebral hemorrhage with large IVH
    Tomofumi Nishikawa
    Department of Neurosurgery, Kishiwada City Hospital, Kishiwada, Osaka, Japan
    Clin Neurol Neurosurg 111:450-3. 2009
    ..In this study, by examining the associations among IVH severity, hydrocephalus, initial level of consciousness and prognosis, we attempted to identify which grade of IVH severity should be considered for surgical treatment...
  58. ncbi Clinical importance of microbleeds in patients receiving IV thrombolysis
    W Kakuda
    Stanford Stroke Center, Stanford University Medical Center, Palo Alto, CA, USA
    Neurology 65:1175-8. 2005
    ..Cerebral microbleeds (MBs) detected on gradient echo (GRE) imaging may be a risk factor for hemorrhagic complications in patients with stroke treated with IV tissue plasminogen activator (tPA)...
  59. ncbi Indomethacin prophylaxis for intraventricular hemorrhage in very low birth weight babies
    P Arun Kumar Nair
    Neonatal Intensive Care Unit, Royal Hospital, Muscat, Sultanate of Oman
    Indian Pediatr 41:551-8. 2004
    ..To study the efficacy and complications of low dose indomethacin in the reduction of major intraventricular hemorrhage (IVH) in very low birth weight (VLBW) babies...
  60. ncbi Angiogenic inhibition reduces germinal matrix hemorrhage
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Nat Med 13:477-85. 2007
    ..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants...
  61. ncbi Prediction model for mortality after intracranial hemorrhage in patients with leukemia
    Farshid Dayyani
    Division of Cancer Medicine, University of Texas, MD Anderson Cancer Center, Houston, USA
    Am J Hematol 86:546-9. 2011
    ....
  62. ncbi Neurologic outcome in neonatal temporal lobe hemorrhagic venous infarcts
    Laurel Slaughter
    Division of Child Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Child Neurol 24:1236-42. 2009
    ..We conclude that neonatal temporal lobe hemorrhagic infarct secondary to suspected superficial temporal venous thrombosis appears to have a good clinical outcome. This is surprising, given the dramatic imaging and clinical presentations...
  63. pmc Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis
    Gordon R Bernard
    Division of Allergy, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Crit Care 7:155-63. 2003
    ....
  64. ncbi IV thrombolysis and statins
    S T Engelter
    Department of Neurology, University Hospital Basel, Basel, Switzerland
    Neurology 77:888-95. 2011
    ..To examine whether prior statin use affects outcome and intracranial hemorrhage (ICH) rates in stroke patients receiving IV thrombolysis (IVT)...
  65. ncbi Risk score model for fatal intracranial hemorrhage in acute leukemia
    H Kim
    Division of Hematology Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
    Leukemia 20:770-6. 2006
    ..001). Overall survival was significantly shorter in the HRG compared with the LRG. The RS model we constructed to predict the occurrence of FICH will be verified through prospective studies...
  66. ncbi Intracranial hemorrhage and vitamin K deficiency associated with biliary atresia: summary of 15 cases and review of the literature
    Hideyuki Akiyama
    Department of Neurosurgery, Kobe Children s Hospital, Kobe, Japan
    Pediatr Neurosurg 42:362-7. 2006
    ..Moreover, early performance of Kasai portoenterostomy is possible even for patients who have undergone craniotomy...
  67. ncbi Risk factors for intracranial hemorrhage among full-term infants: a case-control study
    Balraj S Jhawar
    Department of Neurosurgery, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada
    Neurosurgery 52:581-90; discussion 588-90. 2003
    ..To investigate the cause of intracranial hemorrhage among full-term infants...
  68. ncbi Plasma VAP-1/SSAO activity predicts intracranial hemorrhages and adverse neurological outcome after tissue plasminogen activator treatment in stroke
    Mar Hernandez-Guillamon
    Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Stroke 41:1528-35. 2010
    ..We aimed to study plasma VAP-1/SSAO activity in relation to the risk for intracranial bleeding complications in patients with stroke treated with tissue plasminogen activator (tPA), the greatest safety concern with this treatment...
  69. ncbi Intracranial hemorrhage following bone marrow transplantation: an autopsy study of 58 patients
    L F Bleggi-Torres
    Department of Pathology, Hospital de Clinicas, University of Parana, Curitiba, Brazil
    Bone Marrow Transplant 29:29-32. 2002
    ..011). We conclude that ICH is common and has a significant mortality rate following BMT...
  70. ncbi Prognostic predictors of thalamic hemorrhage
    S D Shah
    Department of Neurology, Sanjay Gandhi Postgraduate, Institute of Medical Sciences, Lucknow, India
    J Clin Neurosci 12:559-61. 2005
    ....
  71. ncbi Prolonged latency after preterm premature rupture of membranes: an evaluation of histologic condition and intracranial ultrasonic abnormality in the neonate born at <28 weeks of gestation
    Thomas F McElrath
    Division of Maternal Fetal Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 189:794-8. 2003
    ....
  72. ncbi Effect of posture on the perception of verticality in neglect patients
    Arnaud Saj
    Service de Rééducation Neurologique and EA 2691, Hôpital Swynghedauw, CHRU de Lille, France
    Stroke 36:2203-5. 2005
    ..These patients have only been assessed when sitting. We investigated the hypothesis that postural changes modulate visuohaptic SV deviation...
  73. ncbi Recurrent thalamic haemorrhage attributed to a cerebellar arteriovenous malformation
    R Sparing
    Department of Neurology, University of Cologne, Cologne, Germany
    Can J Neurol Sci 35:358-9. 2008
  74. ncbi Craniotomy with prosthetic heart valves: a clinical dilemma
    J Caird
    Department of Neurosurgery, Beaumont Hospital, Dublin, Ireland
    Br J Neurosurg 20:40-2. 2006
    ..The authors emphasize the risk of re-anticoagulation without postoperative imaging and the disadvantages of therapeutic dose, low molecular weight heparin in the postoperative period...
  75. ncbi Comparison of five MR sequences for the detection of acute intracranial hemorrhage
    Catherine Oppenheim
    Department of Neuroradiology, Sainte Anne Hospital, Paris V University, France
    Cerebrovasc Dis 20:388-94. 2005
    ..To evaluate the respective value of 5 MR sequences to distinguish between stroke patients with and without acute intracerebral hemorrhage (ICH)...
  76. ncbi Craniotomy with cystoperitoneal shunting for treatment of intracranial arachnoid cysts in dogs
    Curtis W Dewey
    Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    Vet Surg 36:416-22. 2007
    ..To describe a technique of decompressive craniotomy with cystoperitoneal shunt (CPS) placement for treatment of canine intracranial arachnoid cyst (IAC), and to evaluate outcome in 4 dogs...
  77. ncbi [Neurologic complications in the immediate postoperative period after cardiac surgery. Role of brain magnetic resonance imaging]
    José L Pérez-Vela
    Servicio de Medicina Intensiva, Hospital Universitario 12 de Octubre, Madrid, Spain
    Rev Esp Cardiol 58:1014-21. 2005
    ..Our understanding of the pathogenesis, prevention, and management of these lesions is constantly developing...
  78. ncbi Multimodal therapy for the treatment of severe ischemic stroke combining GPIIb/IIIa antagonists and angioplasty after failure of thrombolysis
    Alex Abou-Chebl
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Stroke 36:2286-8. 2005
    ..Multimodal rescue therapy combining mechanical disruption and platelet GPIIb/IIIa receptor antagonists may improve recanalization...
  79. ncbi MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour window
    P D Mitsias
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    Neurology 65:612-5. 2005
    ..Treatment of sub-24-hour stroke with abciximab improves early post-treatment neurologic status and often attenuates ischemic lesion growth...
  80. ncbi Complications of intracranial pressure monitoring in children with head trauma
    Richard C E Anderson
    Primary Children s Medical Center, University of Utah, Department of Neurosurgery, Salt Lake City, Utah, USA
    J Neurosurg 101:53-8. 2004
    ..The purpose of this study was to examine a consecutive series of children with TBI and compare the incidence of complications after placement of an EVD, a fiberoptic intraparencyhmal monitor, or both...
  81. ncbi Leptomeningeal cyst due to vacuum extraction delivery in a twin infant
    L Bobinski
    Department of Neurosurgery, University Hospital, Linkoping, Sweden
    Acta Neurochir (Wien) 149:319-23; discussion 323. 2007
    ..During a follow-up period of 12 years the neurological and psychological development of the boy has been indistinguishable to that of his twin brother, indicating the satisfactory outcome of the treatment...
  82. pmc Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison
    Julio A Chalela
    Medical University of South Carolina, Charleston, SC, USA
    Lancet 369:293-8. 2007
    ..We aimed to prospectively compare CT and MRI for emergency diagnosis of acute stroke...
  83. ncbi Intracranial hemorrhage in newborns with hemophilia: the role of screening radiologic studies in the first 7 days of life
    Angela R Smith
    Department of Pediatric Hematology, University of Minnesota, Minneapolis, MN 55455, USA
    J Pediatr Hematol Oncol 30:81-4. 2008
    ..On the basis of this series we found screening to be safe and effective in recognizing ICH. As a result of this approach, all ICHs were found when they were radiographically small and before the babies had neurologic symptoms...
  84. ncbi Stroke risk factor, pattern and outcome in patients with cancer
    Y Y Zhang
    Department of Aged Care and Rehabilitation, Bankstown Lidcombe Hospital, Sydney, NSW, Australia
    Acta Neurol Scand 114:378-83. 2006
    ..To investigate risk factors, stroke pattern and outcome in stroke patients with cancer...
  85. ncbi [The evaluation of the brain arteriovenous malformations' operative treatment in the clinical material of Silesian Medical University's Departament of Neurosurgery]
    Adam Rudnik
    Katedry i Kliniki Neurochirurgii Slaskiej Akademii Medycznej w Katowicach
    Wiad Lek 59:801-4. 2006
    ..The aim of this work is presentation of our results of surgical treatment of AVM and comparison with the results of radiosurgical and endovascular treatment presented by other authors in the literature...
  86. ncbi [Imaging of neonatal brain disorders: doubts and certitudes]
    S Witte-Meyer
    Service d Imagerie Anténatale, de l Enfant et de la Femme, CHU Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Arch Pediatr 13:672-4. 2006
  87. pmc Pediatric endocarditis and stroke: a single-center retrospective review of seven cases
    Charu Venkatesan
    Division of Neurology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Pediatr Neurol 38:243-7. 2008
    ..Routine surveillance for mycotic aneurysms in patients with new neurologic deficits, and the use of aspirin, should be considered in the medical management...
  88. ncbi Natural history of dural arteriovenous shunts
    Michael Soderman
    Department of Neuroradiology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Stroke 39:1735-9. 2008
    ..Present knowledge about the natural history of these lesions is limited, however. We investigated the incidences of intracranial hemorrhage, progressive dementia syndrome, and death in patients diagnosed in our neurovascular center...
  89. ncbi [Intracranial hemorrhage in term newborn]
    Tomasz Tomasik
    Klinika Chorób Dzieci Katedry, Pediatrii Polsko Amerykański Instytut Pediatrii, Collegium Medicum, Uniwersytetu Jagiellonskiego, Krakow
    Przegl Lek 62:1227-35. 2005
    ..The improvements in perinatal care during last decade have changed clinical presentation of intracranial hemorrhage (ICH) among full-term newborns. New imaging techniques allow for diagnosis of ICH even in asymptomatic babies...
  90. ncbi Fetal intracranial hemorrhage (fetal stroke): report of four antenatally diagnosed cases and review of the literature
    Ying Fen Huang
    Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
    Taiwan J Obstet Gynecol 45:135-41. 2006
    ..However, the true incidence of ICH in utero has not been determined. We present our experience with four cases of fetal ICH (fetal stroke), which was detected prenatally by ultrasonography (US)...
  91. ncbi A risk scoring system for prediction of haemorrhagic stroke
    S P Zodpey
    Department of Preventive and Social Medicine, Clinical Epidemiology Unit, Govt Medical College, Nagpur
    Indian J Public Health 49:218-22. 2005
    ..79 (95% Cl = 0.73-0.84). Thus to conclude, if substantiated by further validation, this scorincy system can be used to predict haemorrhagic stroke, thereby helping to devise effective risk factor intervention strategy...
  92. ncbi Acutely and retrospectively diagnosed perinatal stroke: a population-based study
    Rael Laugesaar
    Children s Clinic of Tartu University Hospital, Tartu, Estonia
    Stroke 38:2234-40. 2007
    ....
  93. ncbi Cerebral microhemorrhage
    Anand Viswanathan
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, France
    Stroke 37:550-5. 2006
    ..This review summarizes the pathophysiology, differential diagnosis, epidemiology, and clinical significance of cerebral microhemorrhages...
  94. ncbi Stroke subtypes among young patients with systemic lupus erythematosus
    Eswar Krishnan
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Med 118:1415. 2005
    ..Little is known about subtypes of stroke in lupus...
  95. ncbi Comparison of clinical diagnosis with computed tomography in ascertaining type of stroke
    Jehangir Khan
    Department of Medicine, Ayub Medical College and Ayub Teaching Hospital, Abbottabad
    J Ayub Med Coll Abbottabad 17:65-7. 2005
    ..This study was carried out to compare clinical diagnosis of stroke with Computed tomography (CT) scan findings in ascertaining the type of stroke (hemorrhagic or ischemic)...
  96. pmc Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase
    C Brekenfeld
    Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Berne, CH 3010 Berne, Switzerland
    J Neurol Neurosurg Psychiatry 78:280-5. 2007
    ..The PROACT II trial showed that intra-arterial thrombolysis (IAT) is effective for treatment of acute ischaemic stroke attributable to M1 and M2 segment occlusions. Incidence of symptomatic intracranial haemorrhage (sICH) was 10%...
  97. ncbi Intracranial haemorrhage among a population of haemophilic patients in Brazil
    S V Antunes
    Serviço de Hemofilia, Disciplina de Hematologia e Hemoterapia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Haemophilia 9:573-7. 2003
    ..This prompt treatment will increase the chances of a better prognosis. Another impact measure consists in the administration of the deficient coagulation factor after every head trauma, even when considered minor...
  98. ncbi Cerebrovascular disorders in children
    John Kylan Lynch
    Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, NIH DHHS, Building 10, Room 5S220, 10 Center Drive, MSC 1447, Bethesda, MD 20892 1447, USA
    Curr Neurol Neurosci Rep 4:129-38. 2004
    ..This review briefly describes the epidemiology, risk factors, evaluation, treatment, and outcome of stroke in children...
  99. ncbi [A clinical study on spontaneous intracranial hemorrhage in children]
    Jia lin Cai
    Zhonghua Er Ke Za Zhi 41:471-2. 2003
  100. ncbi Intraarterial thrombolytic therapy within 3 hours of the onset of stroke
    Eric C Bourekas
    Department of Radiology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Neurosurgery 54:39-44; discussion 44-6. 2004
    ..This study is the first retrospective analysis of a two-institution experience with IA thrombolysis within 3 hours of stroke onset...
  101. ncbi [Dural arteriovenous fistulas with intracranial hemorrhage: diagnostic and therapeutic aspects]
    U Dietrich
    Neuroradiologie, Krankenanstalten Gilead, Bielefeld
    Zentralbl Neurochir 64:12-8. 2003
    ..In the first case definite closure of a remnant of the fistula was refused, in the second no further therapy was recommended...

Research Grants58

  1. COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELS
    Michael Schreiber; Fiscal Year: 1992
    ..Although most reports describe full-term babies, sick preterm babies are a highest risk for intracranial hemorrhages, in part because they have immature capillary vessels and because they may have impaired cerebral ..
  2. Phase 2B Study of TNK in Acute Stroke
    E Haley; Fiscal Year: 2007
    ..1 mg/kg and 0.4 mg/kg without any symptomatic intracranial hemorrhages being observed...
  3. Natural History and Treatment Response of AVMs
    ALEXANDER HALIM; Fiscal Year: 2002
    Brain arteriovenous malformations (BAVM) are usually detected only when the patient presents with intracranial hemorrhages, seizures, headaches, focal neurological deficits, or other disorders. A smaller number are detected incidentally...
  4. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
  5. MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2004
    ..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
  6. Harvard Planning Grant for Institutional Clinical and Translational Science Award
    Daniel Singer; Fiscal Year: 2006
    ..We believe our planning process is specific, innovative yet disciplined, and should be robust. A full and competitive CTSA application will be produced in a timely manner. [unreadable] [unreadable] [unreadable]..
  7. EPIDEMIOLOGY OF ANTICOAGULATION IN ATRIAL FIBRILLATION
    Daniel Singer; Fiscal Year: 2005
    ..In all, continued study of our cohort will efficiently provide powerful insights into optimizing stroke prevention strategies for the many older Americans with AF. ..
  8. Whole Genome Association Study of Migraine in Women
    ROBERT YUK LUNG ZEE; Fiscal Year: 2010
    ..Thus, we request funding to study the genomic of migraine using a whole genome approach and to evaluate gene-environment interactions. ..
  9. Restless Legs Syndrome, Cardiovascular Risk Factors, and Cardiovascular Events
    Tobias Kurth; Fiscal Year: 2010
    ..Thus, this grant proposal request funding to study the association between RLS, CVD risk factors as well as CVD events. ..
  10. Role of NOS3 in the Cerebrovascular Response to TBI
    Claudia Robertson; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  11. Cerebral Hemorrhage Model: Mechanisms and Treatments
    Kenneth Wagner; Fiscal Year: 2005
    ..abstract_text> ..
  12. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..abstract_text> ..
  13. INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASE
    John Kinsella; Fiscal Year: 2004
    ..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
  14. Role of Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2006
    ..abstract_text> ..
  15. Iron Metabolism Alterations in Alzheimer's Disease
    Wolff Kirsch; Fiscal Year: 2006
    ..abstract_text> ..
  16. Mechanisms of Atherosclerosis and CVD in HIV+ Women
    Robert Kaplan; Fiscal Year: 2009
    ..This investigation will have major implications for the development of strategies to predict, prevent, or reverse atherosclerosis in HIV- infected women. ..
  17. Arachidonic Acid in Alzheimer's Disease Pathogenesis
    RENE SANCHEZ MEJIA; Fiscal Year: 2006
    ..I will test whether inhibition of PLA2 will prevent and reverse AD-like morphological, molecular, and functional alterations in hAPP mice. [unreadable] [unreadable] [unreadable]..
  18. PRESENILIN DOMAINS AND RECONSTITUTION OF CATALYSIS
    Samuel Gandy; Fiscal Year: 2007
    ..This investigation will permit the identification of the minimal functional unit for gamma-secretase activity and potentially support the notion that PS1 is indeed the catalytic component of the gamma-secretase complex. ..
  19. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
    ..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. [unreadable] [unreadable] [unreadable]..
  20. Assisted Patient-Selection for Thrombolytics in Stroke
    David Kent; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  22. Simvastatin treatment of experimental intracerebral hemorrhage
    DONALD M SEYFRIED; Fiscal Year: 2010
    ....
  23. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  24. BABAA RECEPTORS IN AGING & ALZHEIMER'S DISEASE
    Samuel Gandy; Fiscal Year: 2002
    ....
  25. MRFASS--MINORITIES, RISK FACTOR AND STROKE STUDY
    Stanley Tuhrim; Fiscal Year: 2003
    ..Stroke-free survival rates will be estimated for each ethnic group and the independent determinants of recurrence will be identified with multivariate statistical techniques. ..
  26. REGULATION OF HUMAN GAMMA AND BETA GLOBIN GENES
    Joyce Lloyd; Fiscal Year: 2003
    ..These results will predict the proteins involved in early beta-globin gene suppression. ..
  27. Rapid quantitation of residual WBCs in filtered blood
    John Roback; Fiscal Year: 2004
    ....
  28. Impact of Aging on Stroke Care: A National Perspective
    Judith Lichtman; Fiscal Year: 2004
    ..We hypothesize that variations in care exist by age. Moreover, these differences in care will not be explained by differences clinical features or co-morbid conditions associated with aging. ..
  29. Extending Safe and Effective Thrombolysis for Stroke
    David Kent; Fiscal Year: 2005
    ..abstract_text> ..
  30. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..
  31. TRANSMITTER NEUROANATOMY IN ALZHEIMERS DISEASE
    Samuel Gandy; Fiscal Year: 2002
    ....
  32. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  33. Genetic factors in outcome from traumatic brain injury
    Ramon Diaz Arrastia; Fiscal Year: 2008
    ..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..
  34. Predoctoral Fellowship for Students with Disabilities
    ELIZABETH GREENWELL; Fiscal Year: 2005
    ..The proposed retrospective cohort study will examine these associations by using multivariate regression methods and longitudinal data analysis. ..
  35. Siblings With Ischemic Stroke Study (SWISS)
    JAMES MESCHIA; Fiscal Year: 2009
    ..DNA banking and the creation of permanent lymphoblastoid cell lines will be done to permit future collaborative efforts to study the genetic basis for stroke risk. ..
  36. Stroke Hospitalization in the Elderly with Medicare FFS
    Judith Lichtman; Fiscal Year: 2009
    ..These results will help inform decisions about the allocation of adequate resources, and more importantly, help identify opportunities to improve care and prevention of elderly stroke patients. ..
  37. WARFARIN VS ASPIRIN FOR INTRACRANIAL ARTERIAL STENOSIS
    Marc Chimowitz; Fiscal Year: 2002
    ..e., greater than or equal to 6 percent per year) to justify a subsequent trial comparing intracranial angioplasty with best medical therapy in these patients. ..
  38. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
  39. MOLECULAR DEFECTS OF FIBRIN STABILIZATION
    Laszlo Lorand; Fiscal Year: 2002
    ..Detection of circulating factor XIIIa activity as an indicator of thrombotic tendency. 4. Fibronectin as the carrier of tissue transglutaminase in plasma. Practical and fundamental considerations. ..
  40. Neurorestorative Therapy of Stroke with Statins
    Jieli Chen; Fiscal Year: 2007
    ..This study provides a new and highly effective way to treat stroke and may permit translation our finding of restorative therapeutic benefit of statin in experimental stroke to the patient. ..
  41. Role of KLF2 in erythropoiesis and globin expression
    Joyce A Lloyd; Fiscal Year: 2010
    ..Our long-term goal is to use KLF2 in strategies to increase embryonic/fetal beta-globin, to treat patients with beta-hemoglobinopathies. ..
  42. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2005
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  43. Pharmacogenetics and Antithrombotic Therapy
    Brian Gage; Fiscal Year: 2003
    ..Using high performance liquid chromatography, we will measure the levels of the 2 enantiomers of warfarin and test Hypothesis 4: Clearance of S-warfarin will be significantly decreased in the presence of 2C9 SNPs. ..
  44. ISGS: The Ischemic Stroke Genetics Study
    JAMES MESCHIA; Fiscal Year: 2006
    ..The application and SWISS share the same definitions for the present and absence of phenotype and key enrollment criteria. ..
  45. MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCH
    Larry Goldstein; Fiscal Year: 2004
    ....
  46. In Vivo Gene Silencing with siRNA After Brain Trauma
    HELEN HELLMICH; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  47. PROGNOSIS OF CHILDREN WITH A FIRST UNPROVOKED SEIZURE
    Shlomo Shinnar; Fiscal Year: 2002
    ....
  48. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
  49. Epidemiology of IGF and Cardiovascular Events
    Robert Kaplan; Fiscal Year: 2005
    ....
  50. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  51. MOLECULAR ANALYSIS OF MYOTONIC DYSTROPHY
    SATYAKAM BHAGWATI; Fiscal Year: 2002
    ..This approach is designed to explore the function of these CTG/CUG repeat binding proteins and their possible role in the pathogenesis of DM. ..
  52. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  53. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2006
    ..abstract_text> ..
  55. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2004
    ..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..