Genomes and Genes
Summary: Bleeding within the intracranial cavity, including hemorrhages in the brain and within the cranial epidural, subdural, and subarachnoid spaces.
Publications214 found, 100 shown here
- Image and diagnosis. Intracranial haemorrhage due to vitamin K deficiency, as the first symptom of extrahepatic biliary atresiaV Ertekin
Faculty of Medicine, Department of Pediatric Gastroenterology, Ataturk University, Erzurum, Turkey
West Indian Med J 54:392, 397. 2005
- Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic strokeAlex K Harris
Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, USA
BMC Neurosci 6:49. 2005..While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the relative contribution of neutrophils to the MMP activity and to the development of hemorrhagic transformation remains unknown...
- Hemorrhagic manifestations of reversible cerebral vasoconstriction syndrome: frequency, features, and risk factorsAnne Ducros
Emergency Headache Center Head and Neck Clinic, Lariboisiere Hospital, Paris, France
Stroke 41:2505-11. 2010..The aim of this study was to describe the frequency, patterns, and risk factors of intracranial hemorrhages in RCVS.
- Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human strokeJoan Montaner
Cerebrovascular Unit, Vall d Hebron Hospital, Barcelona, Spain
Circulation 107:598-603. 2003..We aimed to correlate plasmatic MMP levels with the appearance of intracranial bleeding complications in stroke patients treated with t-PA...
- Intracranial bleeding in patients with traumatic brain injury: a prognostic studyPablo Perel
Epidemiology and Population Health Department, London School of Hygiene and Tropical Medicine, London, UK
BMC Emerg Med 9:15. 2009..We analysed data from the Trauma Audit & Research Network (TARN), a large European trauma registry, to evaluate the association between the size of IB and mortality in patients with TBI...
- Clinical and neuroradiological predictors of mortality in patients with primary pontine hemorrhageKemal Balci
Department of Neurology, School of Medicine, Trakya University, Edirne, Turkey
Clin Neurol Neurosurg 108:36-9. 2005Primary pontine hemorrhage (PPH) accounts approximately for about 5-10% of intracranial hemorrhages, and PPHs are known to have a much less uniform prognosis...
- Risk score model for fatal intracranial hemorrhage in acute leukemiaH Kim
Division of Hematology Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
Leukemia 20:770-6. 2006..001). Overall survival was significantly shorter in the HRG compared with the LRG. The RS model we constructed to predict the occurrence of FICH will be verified through prospective studies...
- Intracranial hemorrhage in late hemorrhagic disease of the newbornPuneet A Pooni
Department of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
Indian Pediatr 40:243-8. 2003..Three patients expired. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. Isolated intracranial hemorrhage is a common mode of presentation...
- Statin use and functional outcome after tissue plasminogen activator treatment in acute ischaemic strokeI Miedema
Department of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Cerebrovasc Dis 29:263-7. 2010..This study investigated whether patients on prior statin therapy and treated with tissue plasminogen activator (tPA) for acute ischaemic stroke have a better functional outcome than statin-naïve patients...
- Prediction model for mortality after intracranial hemorrhage in patients with leukemiaFarshid Dayyani
Division of Cancer Medicine, University of Texas, MD Anderson Cancer Center, Houston, USA
Am J Hematol 86:546-9. 2011....
- Experience of recombinant activated factor VII (NovoSeven) in the operating theatre and intensive care unit for the management of intracranial bleeding in nonhaemophilic patientsMichael Felfernig
Department of Anaesthesia and General Intensive Care, Medical University Vienna, Waehringerguertel 18 20, 1090 Vienna, Austria
Clin Neurol Neurosurg 110:227-32. 2008..Our aim was to explore the use of recombinant activated factor VII (rFVIIa NovoSeven Novo Nordisk, A/S, Bagsvaerd, Denmark) for the management of ICH in the operating theater and intensive care unit...
- Neurodevelopmental outcome in children with posthemorrhagic hydrocephalusYasuyuki Futagi
Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho, Izumi, Osaka 594 1101, Japan
Pediatr Neurol 33:26-32. 2005....
- Recombinant factor VIIa for warfarin-associated intracranial bleedingCan Ilyas
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Clin Anesth 20:276-9. 2008..To examine the efficacy of recombinant factor VIIa (rVIIa) in reversing warfarin-induced coagulopathy in trauma patients presenting with intracranial hemorrhage (ICH)...
- Prediction of fatal intracranial hemorrhage in patients with acute myeloid leukemiaC Y Chen
Department of Internal Medicine, Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan
Ann Oncol 20:1100-4. 2009..Intracranial hemorrhage (ICH) is the second leading cause of mortality in patients with acute myeloid leukemia (AML). However, the prognostic factors for ICH in AML patients are still under investigation...
- Intracranial hemorrhage due to late hemorrhagic disease in two siblingsHuseyin Per
Department of Pediatric Neurology, Erciyes University Medical Faculty, Kayseri, Turkey
J Emerg Med 31:49-52. 2006..In this study, we report on two siblings with intracranial bleeding who were fully breastfed without a routine supplementation of vitamin K. Vitamin K should be given to all newborns as a single, intramuscular dose of 1 mg...
- Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literatureMatthew R Naunheim
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Clin Neurol Neurosurg 112:575-7. 2010..This case demonstrates that the presence of hyperleukocytosis in a patient with intracerebral hemorrhage should raise clinical suspicion for acute leukemia as the cause of the ICH...
- Warfarin and intracranial haemorrhageRebecca Appelboam
Anaesthesia and Intensive Care Medicine, Royal Devon and Exeter Hospital, Barrack Road, Exeter, Devon, UK
Blood Rev 23:1-9. 2009..The specific management of patients with prosthetic heart valves is also discussed. A summary of current societal guidelines is also included, as are some key practice points...
- Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of ageThuy Mai Luu
Women and Infants Hospital, Department of Pediatrics, 101 Dudley St, Providence, RI 02905, USA
Pediatrics 123:1037-44. 2009....
- Angiogenic inhibition reduces germinal matrix hemorrhagePraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Nat Med 13:477-85. 2007..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants...
- Intracranial haemorrhage due to late onset vitamin K deficiency bleeding in Hanoi province, VietnamN Danielsson
Astrid Lindgren s Children s Hospital, Stockholm, Sweden
Arch Dis Child Fetal Neonatal Ed 89:F546-50. 2004..In many developing countries vitamin K prophylaxis is not routinely administered at birth. There are insufficient data to assess the cost effectiveness of its implementation in such countries...
- Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational studyNils Wahlgren
Department of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Lancet 369:275-82. 2007..Under European Union regulations, SITS-MOST was required to assess the safety profile of alteplase in clinical practice by comparison with results in randomised controlled trials...
- The prognostic impact of clinical and CT parameters in patients with pontine hemorrhageRainer Dziewas
Department of Neurology, University of Munster, Munster, Germany
Cerebrovasc Dis 16:224-9. 2003..In patients with pontine hemorrhage (PH), an accurate prognostic assessment is critical for establishing a reasonable therapeutic approach...
- Intracranial hemorrhages due to late-type vitamin K deficiency bleedingMelih Cekinmez
Department of Neurosurgery, Faculty of Medicine, Baskent University, Dadaloglu Mahallesi, 01250, Yuregir, Adana, Turkey
Childs Nerv Syst 24:821-5. 2008..Late-type VKDB has particular importance due to frequent intracranial hemorrhages that lead to high mortality and morbidity...
- Plasma VAP-1/SSAO activity predicts intracranial hemorrhages and adverse neurological outcome after tissue plasminogen activator treatment in strokeMar Hernandez-Guillamon
Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
Stroke 41:1528-35. 2010..We aimed to study plasma VAP-1/SSAO activity in relation to the risk for intracranial bleeding complications in patients with stroke treated with tissue plasminogen activator (tPA), the greatest safety concern with this treatment...
- Migraine and risk of haemorrhagic stroke in women: prospective cohort studyTobias Kurth
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
BMJ 341:c3659. 2010..To examine the association between migraine and migraine aura status with risk of haemorrhagic stroke...
- S100B protein in biological fluids: a tool for perinatal medicineFabrizio Michetti
Institute of Anatomy, Catholic University, Largo Francesco Vito 1, I 00168 Rome, Italy
Clin Chem 48:2097-104. 2002..Finally, because of the neurotrophic role putatively played by S100B, its measurement in biological fluids at pre-/perinatal ages makes it a candidate for the laboratory evaluation of brain maturation...
- Intracranial hemorrhage and vitamin K deficiency associated with biliary atresia: summary of 15 cases and review of the literatureHideyuki Akiyama
Department of Neurosurgery, Kobe Children s Hospital, Kobe, Japan
Pediatr Neurosurg 42:362-7. 2006..Moreover, early performance of Kasai portoenterostomy is possible even for patients who have undergone craniotomy...
- Reliability of diagnosis of traumatic brain injury by computed tomography in the acute phaseJussi P Laalo
Medical Imaging Centre, Turku University Central Hospital, Turku, Finland
J Neurotrauma 26:2169-78. 2009..Experience increased accuracy, yet even between the reports of the most experienced readers, there were marked differences...
- Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhageDavid L Brody
Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Neurocrit Care 2:263-7. 2005..Current therapies are associated with significant complications and/or prolonged time to correction of coagulopathy. Recombinant factor VIIa (FVIIa) might allow faster and safer correction of coagulopathy...
- Cause is the main predictor of outcome in patients with pontine hemorrhageAlejandro A Rabinstein
Neurological Neurosurgical Intensive Care Unit, Saint Mary s Hospital, Rochester, Minn, USA
Cerebrovasc Dis 17:66-71. 2004..Pontine hemorrhages frequently lead to death or severe disability. Predictors of early mortality have been previously described but little is known about the factors influencing long-term disability...
- Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigationGuy Rosenthal
Department of Neurosurgery, University of California, San Francisco, CA 94117, USA
J Neurosurg 108:575-87. 2008..We studied the effects of hemoglobin-based oxygen-carrying (HBOC)-201 solution compared with lactated Ringer (LR) solution in a large animal model of brain injury and hemorrhage, in a blinded prospective randomized study...
- Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic strokeMar Castellanos
Department of Neurology, Hospital Universitari Doctor Josep Trueta in affiliation with the UAB, Avda Francia s n, Girona 17007, Spain
Stroke 35:1671-6. 2004..We investigated whether high plasma levels of c-Fn were associated with hemorrhagic transformation (HT) after treatment with tissue plasminogen activator (tPA) in patients with acute stroke...
- Different risk factors for different stroke subtypes: association of blood pressure, cholesterol, and antioxidantsJ M Leppälä
Department of Public Health, University of Helsinki, Finland
Stroke 30:2535-40. 1999..Blood pressure is an important risk factor for stroke, but the roles of serum total and HDL cholesterol, alpha-tocopherol, and beta-carotene are poorly established. We studied these factors in relation to stroke subtypes...
- Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibitionGovindaiah Vinukonda
Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
Brain 133:2264-80. 2010....
- IV thrombolysis and statinsS T Engelter
Department of Neurology, University Hospital Basel, Basel, Switzerland
Neurology 77:888-95. 2011..To examine whether prior statin use affects outcome and intracranial hemorrhage (ICH) rates in stroke patients receiving IV thrombolysis (IVT)...
- Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infantsB Schmidt
Department of Pediatrics, McMaster University, Hamilton, Ont, Canada
N Engl J Med 344:1966-72. 2001..Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known...
- Indomethacin prophylaxis for intraventricular hemorrhage in very low birth weight babiesP Arun Kumar Nair
Neonatal Intensive Care Unit, Royal Hospital, Muscat, Sultanate of Oman
Indian Pediatr 41:551-8. 2004..To study the efficacy and complications of low dose indomethacin in the reduction of major intraventricular hemorrhage (IVH) in very low birth weight (VLBW) babies...
- Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone stateJulio A Chalela
National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892 1063, USA
J Neuroimaging 14:54-7. 2004Recent reports have indicated that cerebral microbleeds (CMBs) detected on gradient-echo (GRF) magnetic resonance imaging may be a risk factor for therapy related intracranial hemorrhages (ICHs).
- Clinical importance of microbleeds in patients receiving IV thrombolysisW Kakuda
Stanford Stroke Center, Stanford University Medical Center, Palo Alto, CA, USA
Neurology 65:1175-8. 2005..Cerebral microbleeds (MBs) detected on gradient echo (GRE) imaging may be a risk factor for hemorrhagic complications in patients with stroke treated with IV tissue plasminogen activator (tPA)...
- Spontaneous superficial parenchymal and leptomeningeal hemorrhage in term neonatesAmy H Huang
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA
AJNR Am J Neuroradiol 25:469-75. 2004..In this study, we review the clinical and neuroimaging features of healthy term neonates presenting with spontaneous superficial parenchymal and leptomeningeal (ie, subpial or subarachnoid) hemorrhage...
- Early biomarkers of strokeMark A Reynolds
Biosite Incorporated, 11030 Roselle St, San Diego, CA 92121 Duke University Medical Center, Box 2900, Durham, NC 27710, USA
Clin Chem 49:1733-9. 2003..The ability to correlate blood-borne protein biomarkers with stroke phenotypes would aid in the development of such rapid tests...
- Migraine, headache, and the risk of stroke in women: a prospective studyT Kurth
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
Neurology 64:1020-6. 2005..Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse...
- Neurologic outcome in neonatal temporal lobe hemorrhagic venous infarctsLaurel Slaughter
Division of Child Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Child Neurol 24:1236-42. 2009..We conclude that neonatal temporal lobe hemorrhagic infarct secondary to suspected superficial temporal venous thrombosis appears to have a good clinical outcome. This is surprising, given the dramatic imaging and clinical presentations...
- Hypertensive pontine microhemorrhageJee Hyang Jeong
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Stroke 33:925-9. 2002..This study investigated whether the topography of hypertensive pontine microhemorrhages (hPMHs) resembles that of larger primary pontine hemorrhages...
- A review of genetic causes of ischemic and hemorrhagic strokeMartijn Tonk
Department of Neurology, Leiden University Medical Centre, The Netherlands
J Neurol Sci 257:273-9. 2007..Animal model of stroke can also provide valuable information on genetic factors involved in stroke predisposition. In this review, the focus lies on monogenic forms of stroke that can serve as models to study the more common phenotypes...
- Neonatal complications of vacuum-assisted deliveryColin Simonson
Department of Obstetrics and Gynaecology, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Buxelles, Brussels, Belgium
Obstet Gynecol 109:626-33. 2007....
- Intracerebellar hemorrhage in premature infants: sonographic detection and outcomeHanna Müller
Division of Neonatology, Department of Pediatrics, University of Heidelberg, Germany
J Perinat Med 35:67-70. 2007..Intracerebellar hemorrhage is a rarely confirmed diagnosis in preterm infants in comparison to peri-/intraventricular hemorrhage. This study evaluates the incidence of intracerebellar hemorrhage and neurological outcome in preterm infants...
- Stroke after bone marrow transplantation: frequency, aetiology and outcomeW M Coplin
Division of Pulmonary and Critical Care Medicine and the Department of Neurology, University of Washington, Seattle, Washington, USA
Brain 124:1043-51. 2001..Stroke occurs relatively frequently (incidence almost 3%) after BMT, has a relatively high frequency of infection-triggered events, has a neurological outcome not easily predicted from available data and is often fatal...
- Intracranial hemorrhage in term newborns: management and outcomesSurya N Gupta
Department of Pediatric Neurology, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
Pediatr Neurol 40:1-12. 2009....
- Risk factors for intracranial hemorrhage among full-term infants: a case-control studyBalraj S Jhawar
Department of Neurosurgery, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada
Neurosurgery 52:581-90; discussion 588-90. 2003..To investigate the cause of intracranial hemorrhage among full-term infants...
- Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsisGordon R Bernard
Division of Allergy, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Crit Care 7:155-63. 2003....
- Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhageWilliam D Freeman
Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla 32224, USA
Mayo Clin Proc 79:1495-500. 2004..To assess the effects of recombinant factor VIIa (rFVIIa) on hemorrhage volume and functional outcomes in warfarin-related acute intracranial hemorrhage (ICH), which has a 30-day mortality of more than 50%...
- Intracranial hemorrhage following bone marrow transplantation: an autopsy study of 58 patientsL F Bleggi-Torres
Department of Pathology, Hospital de Clinicas, University of Parana, Curitiba, Brazil
Bone Marrow Transplant 29:29-32. 2002..011). We conclude that ICH is common and has a significant mortality rate following BMT...
- Predictors of clinical improvement, angiographic recanalization, and intracranial hemorrhage after intra-arterial thrombolysis for acute ischemic strokeJ I Suarez
Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
Stroke 30:2094-100. 1999..We sought to evaluate predictors of clinical outcome, angiographic success, and adverse effects after intra-arterial administration of urokinase for acute ischemic stroke...
- Prognostic predictors of thalamic hemorrhageS D Shah
Department of Neurology, Sanjay Gandhi Postgraduate, Institute of Medical Sciences, Lucknow, India
J Clin Neurosci 12:559-61. 2005....
- Intracranial hemorrhage in asymptomatic neonates: prevalence on MR images and relationship to obstetric and neonatal risk factorsChristopher B Looney
Department of Psychiatry, CB No 7160, 7025A Neurosciences Hospital, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Radiology 242:535-41. 2007..To retrospectively evaluate the prevalence of neonatal intracranial hemorrhage (ICH) and its relationship to obstetric and neonatal risk factors...
- Prolonged latency after preterm premature rupture of membranes: an evaluation of histologic condition and intracranial ultrasonic abnormality in the neonate born at <28 weeks of gestationThomas F McElrath
Division of Maternal Fetal Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 189:794-8. 2003....
- Pediatric endocarditis and stroke: a single-center retrospective review of seven casesCharu Venkatesan
Division of Neurology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Pediatr Neurol 38:243-7. 2008..Routine surveillance for mycotic aneurysms in patients with new neurologic deficits, and the use of aspirin, should be considered in the medical management...
- Complications of intracranial pressure monitoring in children with head traumaRichard C E Anderson
Primary Children s Medical Center, University of Utah, Department of Neurosurgery, Salt Lake City, Utah, USA
J Neurosurg 101:53-8. 2004..The purpose of this study was to examine a consecutive series of children with TBI and compare the incidence of complications after placement of an EVD, a fiberoptic intraparencyhmal monitor, or both...
- Craniotomy with cystoperitoneal shunting for treatment of intracranial arachnoid cysts in dogsCurtis W Dewey
Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
Vet Surg 36:416-22. 2007..To describe a technique of decompressive craniotomy with cystoperitoneal shunt (CPS) placement for treatment of canine intracranial arachnoid cyst (IAC), and to evaluate outcome in 4 dogs...
- MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour windowP D Mitsias
Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
Neurology 65:612-5. 2005..Treatment of sub-24-hour stroke with abciximab improves early post-treatment neurologic status and often attenuates ischemic lesion growth...
- Recurrent thalamic haemorrhage attributed to a cerebellar arteriovenous malformationR Sparing
Department of Neurology, University of Cologne, Cologne, Germany
Can J Neurol Sci 35:358-9. 2008
- [Thrombolytic therapy in acute ischemic stroke. Critical analysis of current knowledge]Veronica Murray
Medicinska kliniken, Danderyds sjukhus, Stockholm
Lakartidningen 101:662-8, 670-3. 2004..Giving priority to new large randomized controlled trials is essential to achieve this knowledge...
- Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparisonJulio A Chalela
Medical University of South Carolina, Charleston, SC, USA
Lancet 369:293-8. 2007..We aimed to prospectively compare CT and MRI for emergency diagnosis of acute stroke...
- Natural history of dural arteriovenous shuntsMichael Soderman
Department of Neuroradiology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
Stroke 39:1735-9. 2008..Present knowledge about the natural history of these lesions is limited, however. We investigated the incidences of intracranial hemorrhage, progressive dementia syndrome, and death in patients diagnosed in our neurovascular center...
- Intracranial hemorrhage in newborns with hemophilia: the role of screening radiologic studies in the first 7 days of lifeAngela R Smith
Department of Pediatric Hematology, University of Minnesota, Minneapolis, MN 55455, USA
J Pediatr Hematol Oncol 30:81-4. 2008..On the basis of this series we found screening to be safe and effective in recognizing ICH. As a result of this approach, all ICHs were found when they were radiographically small and before the babies had neurologic symptoms...
- Treatment of intracranial and extracranial haemorrhages in a neonate with severe haemophilia B with recombinant factor IX infusionG M T Guilcher
Department of Paediatrics, Janeway Children s Health and Rehabilitation Centre, Memorial University of Newfoundland, St John s, NL, Canada
Haemophilia 11:411-4. 2005..A neonate with severe haemophilia B was treated successfully with recombinant FIX through continuous infusion. A high rate of infusion was required and no complications were noted...
- Effect of posture on the perception of verticality in neglect patientsArnaud Saj
Service de Rééducation Neurologique and EA 2691, Hôpital Swynghedauw, CHRU de Lille, France
Stroke 36:2203-5. 2005..These patients have only been assessed when sitting. We investigated the hypothesis that postural changes modulate visuohaptic SV deviation...
- Multimodal therapy for the treatment of severe ischemic stroke combining GPIIb/IIIa antagonists and angioplasty after failure of thrombolysisAlex Abou-Chebl
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Stroke 36:2286-8. 2005..Multimodal rescue therapy combining mechanical disruption and platelet GPIIb/IIIa receptor antagonists may improve recanalization...
- [Imaging of neonatal brain disorders: doubts and certitudes]S Witte-Meyer
Service d Imagerie Anténatale, de l Enfant et de la Femme, CHU Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
Arch Pediatr 13:672-4. 2006
- Stroke risk factor, pattern and outcome in patients with cancerY Y Zhang
Department of Aged Care and Rehabilitation, Bankstown Lidcombe Hospital, Sydney, NSW, Australia
Acta Neurol Scand 114:378-83. 2006..To investigate risk factors, stroke pattern and outcome in stroke patients with cancer...
- Fetal intracranial hemorrhage (fetal stroke): report of four antenatally diagnosed cases and review of the literatureYing Fen Huang
Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
Taiwan J Obstet Gynecol 45:135-41. 2006..However, the true incidence of ICH in utero has not been determined. We present our experience with four cases of fetal ICH (fetal stroke), which was detected prenatally by ultrasonography (US)...
- Leptomeningeal cyst due to vacuum extraction delivery in a twin infantL Bobinski
Department of Neurosurgery, University Hospital, Linkoping, Sweden
Acta Neurochir (Wien) 149:319-23; discussion 323. 2007..During a follow-up period of 12 years the neurological and psychological development of the boy has been indistinguishable to that of his twin brother, indicating the satisfactory outcome of the treatment...
- [Intracranial hemorrhage in term newborn]Tomasz Tomasik
Klinika Chorób Dzieci Katedry, Pediatrii Polsko Amerykański Instytut Pediatrii, Collegium Medicum, Uniwersytetu Jagiellonskiego, Krakow
Przegl Lek 62:1227-35. 2005..The improvements in perinatal care during last decade have changed clinical presentation of intracranial hemorrhage (ICH) among full-term newborns. New imaging techniques allow for diagnosis of ICH even in asymptomatic babies...
- A risk scoring system for prediction of haemorrhagic strokeS P Zodpey
Department of Preventive and Social Medicine, Clinical Epidemiology Unit, Govt Medical College, Nagpur
Indian J Public Health 49:218-22. 2005..79 (95% Cl = 0.73-0.84). Thus to conclude, if substantiated by further validation, this scorincy system can be used to predict haemorrhagic stroke, thereby helping to devise effective risk factor intervention strategy...
- Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinaseC Brekenfeld
Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Berne, CH 3010 Berne, Switzerland
J Neurol Neurosurg Psychiatry 78:280-5. 2007..The PROACT II trial showed that intra-arterial thrombolysis (IAT) is effective for treatment of acute ischaemic stroke attributable to M1 and M2 segment occlusions. Incidence of symptomatic intracranial haemorrhage (sICH) was 10%...
- Cerebral microhemorrhageAnand Viswanathan
Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, France
Stroke 37:550-5. 2006..This review summarizes the pathophysiology, differential diagnosis, epidemiology, and clinical significance of cerebral microhemorrhages...
- Comparison of clinical diagnosis with computed tomography in ascertaining type of strokeJehangir Khan
Department of Medicine, Ayub Medical College and Ayub Teaching Hospital, Abbottabad
J Ayub Med Coll Abbottabad 17:65-7. 2005..This study was carried out to compare clinical diagnosis of stroke with Computed tomography (CT) scan findings in ascertaining the type of stroke (hemorrhagic or ischemic)...
- [The evaluation of the brain arteriovenous malformations' operative treatment in the clinical material of Silesian Medical University's Departament of Neurosurgery]Adam Rudnik
Katedry i Kliniki Neurochirurgii Slaskiej Akademii Medycznej w Katowicach
Wiad Lek 59:801-4. 2006..The aim of this work is presentation of our results of surgical treatment of AVM and comparison with the results of radiosurgical and endovascular treatment presented by other authors in the literature...
- Acutely and retrospectively diagnosed perinatal stroke: a population-based studyRael Laugesaar
Children s Clinic of Tartu University Hospital, Tartu, Estonia
Stroke 38:2234-40. 2007....
- Comparison of five MR sequences for the detection of acute intracranial hemorrhageCatherine Oppenheim
Department of Neuroradiology, Sainte Anne Hospital, Paris V University, France
Cerebrovasc Dis 20:388-94. 2005..To evaluate the respective value of 5 MR sequences to distinguish between stroke patients with and without acute intracerebral hemorrhage (ICH)...
- [Neurologic complications in the immediate postoperative period after cardiac surgery. Role of brain magnetic resonance imaging]José L Pérez-Vela
Servicio de Medicina Intensiva, Hospital Universitario 12 de Octubre, Madrid, Spain
Rev Esp Cardiol 58:1014-21. 2005..Our understanding of the pathogenesis, prevention, and management of these lesions is constantly developing...
- Craniotomy with prosthetic heart valves: a clinical dilemmaJ Caird
Department of Neurosurgery, Beaumont Hospital, Dublin, Ireland
Br J Neurosurg 20:40-2. 2006..The authors emphasize the risk of re-anticoagulation without postoperative imaging and the disadvantages of therapeutic dose, low molecular weight heparin in the postoperative period...
- Conservative management of spontaneous posterior fossa subdural hematoma in a neonateHaydar Usul
Department of Neurosurgery, School of Medicine, Karadeniz Technical University, Trabzon, Turkey
J Clin Neurosci 12:196-8. 2005..Diagnosis is with computed tomography and magnetic resonance imaging. We present a spontaneous posterior fossa subdural hematoma in a term neonate and discuss conservative management...
- Imaging perinatal brain injury in premature infantsJeffrey J Neil
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Semin Perinatol 28:433-43. 2004..Current guidelines regarding the application of these neuroimaging methods to the premature infant are discussed...
- Time lag to diagnosis of stroke in childrenLidia V Gabis
Department of Neurology, State University of New York at Stony Brook, Stony Brook, New York 11794 8790, USA
Pediatrics 110:924-8. 2002..We evaluated whether children who receive a diagnosis of stroke meet a major inclusion criterion for such trials, namely time to diagnosis of <3 to 6 hours...
- Analysis of the safety and efficacy of intra-arterial thrombolytic therapy in ischemic strokeRejane C Lisboa
Departments of Neurology, Northwestern University Medical School, Chicago, Illinois, USA
Stroke 33:2866-71. 2002..Intra-arterial thrombolytic therapy (IAT) may be a treatment option for patients with ischemic stroke. We analyzed the safety and efficacy of IAT on the basis of published data...
- [A clinical study on spontaneous intracranial hemorrhage in children]Jia lin Cai
Zhonghua Er Ke Za Zhi 41:471-2. 2003
- Intraarterial thrombolytic therapy within 3 hours of the onset of strokeEric C Bourekas
Department of Radiology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
Neurosurgery 54:39-44; discussion 44-6. 2004..This study is the first retrospective analysis of a two-institution experience with IA thrombolysis within 3 hours of stroke onset...
- Carotid dissection with permanent and transient occlusion or severe stenosis: Long-term outcomeC Kremer
Department of Neurology, University Hospitals of Zürich Drs Kremer, Mosso, Georgiadis, Benninger, Baumgartner, Bern, Switzerland
Neurology 60:271-5. 2003..To compare the rate of ischemic events and intracranial hemorrhage in the long-term follow-up of patients with persistent and transient severe stenosis or occlusion of the internal carotid artery (ICA) due to spontaneous dissection (ICAD)...
- Intracranial haemorrhage among a population of haemophilic patients in BrazilS V Antunes
Serviço de Hemofilia, Disciplina de Hematologia e Hemoterapia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
Haemophilia 9:573-7. 2003..This prompt treatment will increase the chances of a better prognosis. Another impact measure consists in the administration of the deficient coagulation factor after every head trauma, even when considered minor...
- Are some patients likely to benefit from recombinant tissue-type plasminogen activator for acute ischemic stroke even beyond 3 hours from symptom onset?David M Kent
Division of Clinical Care Research, Tufts New England Medical Center, Boston, Mass 02111, USA
Stroke 34:464-7. 2003....
- Stroke in childrenSheffali Gulati
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
Indian J Pediatr 70:639-48. 2003..Mortality after stroke in children ranges from 20% to 30% depending on the location and the underlying cause. Residual neurological dysfunction is present in more than 50% of survivors...
- [Dural arteriovenous fistulas with intracranial hemorrhage: diagnostic and therapeutic aspects]U Dietrich
Neuroradiologie, Krankenanstalten Gilead, Bielefeld
Zentralbl Neurochir 64:12-8. 2003..In the first case definite closure of a remnant of the fistula was refused, in the second no further therapy was recommended...
- Visible infarction on computed tomography is an independent predictor of poor functional outcome after stroke, and not of haemorrhagic transformationJ M Wardlaw
Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
J Neurol Neurosurg Psychiatry 74:452-8. 2003....
- Central post-stroke pain or paresthesia in lenticulocapsular hemorrhagesJong S Kim
Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Korea
Neurology 61:679-82. 2003..The mean score of the visual numerical scale was 5.6. The lesions involved the dorsal part of the posterior limb of the internal capsule, probably damaging the thalamocortical sensory pathway...
- Stroke in childrenVinita Jain
Sir Ganga Ram Hospital, New Delhi, India
Indian J Pediatr 70:S23-7. 2003..The treatment of stroke is largely for stabilization of the patient, but it is very important to know the cause to prevent future strokes. Use of heparin in ischemic stroke is very promising and thrombolytic therapy is under trial...
- Acquired aqueductal stenosis in preterm infants: an indication for neuroendoscopic third ventriculostomyD Scavarda
Department of Pediatric Neurosurgery, Hopital des Enfants, La Timone, 13385 Marseille Cedex 05, France
Childs Nerv Syst 19:756-9. 2003..The object of this study is to demonstrate the delayed occurrence of aqueductal stenosis in preterm infants who have suffered from intraventricular hemorrhage (IVH) and to try to explain the mechanisms of this stenosis...
- Spontaneous intracranial haemorrhage in children: aetiology, presentation and outcomeAndreas D Meyer-Heim
Division of Paediatric Neurology, University Children s Hospital, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
Brain Dev 25:416-21. 2003..Mortality (25%, 8/32) and morbidity were considerable, particularly in infratentorial haemorrhages, in aneurysms, in children younger than 3 years and in those with underlying haematological disorders...
- Cerebrovascular disorders in childrenJohn Kylan Lynch
Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, NIH DHHS, Building 10, Room 5S220, 10 Center Drive, MSC 1447, Bethesda, MD 20892 1447, USA
Curr Neurol Neurosci Rep 4:129-38. 2004..This review briefly describes the epidemiology, risk factors, evaluation, treatment, and outcome of stroke in children...
- Arteriovenous malformation of the genu of the corpus callosumOmid J Bendavid
Division of Neurosurgery, Department of Surgery, University of Vermont College of Medicine, Burlington, VT, USA
Pediatr Neurosurg 40:49-50. 2004
Research Grants123 found, 100 shown here
- Phase 2B Study of TNK in Acute StrokeE Haley; Fiscal Year: 2007..1 mg/kg and 0.4 mg/kg without any symptomatic intracranial hemorrhages being observed...
- Natural History and Treatment Response of AVMsALEXANDER HALIM; Fiscal Year: 2002Brain arteriovenous malformations (BAVM) are usually detected only when the patient presents with intracranial hemorrhages, seizures, headaches, focal neurological deficits, or other disorders. A smaller number are detected incidentally...
- Anticoagulation Treatment and Long-Term Outcomes After Venous ThromboembolismMargaret C Fang; Fiscal Year: 2010..This project will evaluate current treatment patterns for VTE, identify risk factors for adverse outcomes, and develop clinically applicable risk-stratification tools to help predict recurrent VTE and major hemorrhagic complications. ..
- Risks of Warfarin for Elders with Atrial FibrillationMargaret Fang; Fiscal Year: 2007..Together, these projects will provide practical experience and form the basis for future studies that seek to improve the safety and use of anticoagulants in the oldest patients with atrial fibrillation. ..
- White matter injury in germinal matrix hemorrhagePraveen Ballabh; Fiscal Year: 2010..Hence, the proposed study will elucidate the mechanism of white matter injury in IVH and may lead to novel strategies in prevention of cerebral palsy in premature infants. ..
- Novel Therapies in Hemostasis and TransfusionJames Bussel; Fiscal Year: 2007..Dr. James Bussel, as our site's Primary Investigator, is responsible for ensuring that all aspects of TMH Network protocols are followed. WEILL CORNELL MEDICAL CENTER/NEW YORK PRESBYTERIAN HOSPITAL CRITIQUES ..
- Pericytes in Pathogenesis of Germinal-Matrix HemorrhagePraveen Ballabh; Fiscal Year: 2006..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. ..
- Neurovascular Adhesion Receptors and Barrier IntegrityGregory Del Zoppo; Fiscal Year: 2009..abstract_text> ..
- MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIAGregory Del Zoppo; Fiscal Year: 2004..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
- MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIAGregory Del Zoppo; Fiscal Year: 2007..These studies are likely to lead to new testable therapeutic approaches to preserve mlcrovascular and neuron function which will have relevance to other vascular neuron degenerative disorders. ..
- Neurovascular Adhesion Receptors and Barrier IntegrityGregory Del Zoppo; Fiscal Year: 2007..Understanding the mechanisms of their expression and disruption is likely to lead to new testable approaches to preserve or selectively alter barrier function and microvessel integrity in other neurovascular degenerative disorders. ..
- MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIAGregory Del Zoppo; Fiscal Year: 1999..In view of clinical studies demonstrating successful cerebral arterial recanalization, the approaches in this proposal may have significant consequences for future acute stroke patient management and outcome. ..
- MICROVASCULAR OCCLUSIONS--ACUTE FOCAL CEREBRAL ISCHEMIAGregory Del Zoppo; Fiscal Year: 1991..This approach may have significant consequences for acute stroke patient management...
- MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIAGregory Del Zoppo; Fiscal Year: 1993..In view of clinical studies demonstrating successful cerebral arterial recanalization, the approaches in this proposal may have significant consequences for future acute stroke patient management and outcome...
- Neurovascular Adhesion Receptors and Barrier IntegrityGregory J del Zoppo; Fiscal Year: 2010..abstract_text> ..
- EPIDEMIOLOGY OF ANTICOAGULATION IN ATRIAL FIBRILLATIONDaniel Singer; Fiscal Year: 2005..In all, continued study of our cohort will efficiently provide powerful insights into optimizing stroke prevention strategies for the many older Americans with AF. ..
- Harvard Planning Grant for Institutional Clinical and Translational Science AwardDaniel Singer; Fiscal Year: 2006..We believe our planning process is specific, innovative yet disciplined, and should be robust. A full and competitive CTSA application will be produced in a timely manner. ..
- Whole Genome Association Study of Migraine in WomenROBERT YUK LUNG ZEE; Fiscal Year: 2010..Thus, we request funding to study the genomic of migraine using a whole genome approach and to evaluate gene-environment interactions. ..
- EPIDEMIOLOGY OF ANTICOAGULATION IN ATRIAL FIBRILLATIONDaniel Singer; Fiscal Year: 2000..comparison of the quality of anticoagulation provided by anticoagulation units versus that of primary physicians. The investigators state that this research should lead to important health and economic benefits for older Americans. ..
- The Significance of Intracranial Hemorrhage after Revascularization TherapyPooja Khatri; Fiscal Year: 2007..Therapies that restore blood flow to more patients, and do so more effectively and safely, are greatly needed to improve outcomes after stroke. ..
- Restless Legs Syndrome, Cardiovascular Risk Factors, and Cardiovascular EventsTobias Kurth; Fiscal Year: 2009..Thus, this grant proposal request funding to study the association between RLS, CVD risk factors as well as CVD events. ..
- Restless Legs Syndrome, Cardiovascular Risk Factors, and Cardiovascular EventsTobias Kurth; Fiscal Year: 2010..Thus, this grant proposal request funding to study the association between RLS, CVD risk factors as well as CVD events. ..
- Whole Genome Association Study of Migraine in WomenTobias Kurth; Fiscal Year: 2009..Thus, we request funding to study the genomic of migraine using a whole genome approach and to evaluate gene-environment interactions. ..
- Vascular Mechanisms of Secondary Injury After TBIClaudia Robertson; Fiscal Year: 2007..Effect of Erythropoietin on Anemia and Need for Transfusion Project 3. EDHF Following Traumatic Brain Injury Project 4. Neuroprotection of Erythropoietin Signaling in TBI ..
- In Vivo RNAi of Injury Signals After Brain InjuryHELEN HELLMICH; Fiscal Year: 2007..In turn, this may open up avenues for therapeutic manipulation of deleterious gene expression in human patients. ..
- Consequences of Prolonged Febrile Seizures in ChildhoodShlomo Shinnar; Fiscal Year: 2010....
- fMRI of Language Recover Following Stroke in AdultsJerzy P Szaflarski; Fiscal Year: 2010....
- Angiogenic Agents and Alveolar InjuryVineet Bhandari; Fiscal Year: 2007..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
- Prenatal Cocaine Exposure: Adolescent Follow-upDeborah Frank; Fiscal Year: 2007..Such data can inform clinical interventions and public policy choices for care of youngsters with IUCE from infancy to adolescence. ..
- Inflammatory and Immune Mechanisms of Atherosclerosis in HIV-Infected WomenRobert C Kaplan; Fiscal Year: 2010..g., lipids) over time due to changes in HAART and HIV disease stage, and how this impacts atherosclerosis. (End of Abstract) ..
- Dissociating Components of the Attentional Network in NeglectChristopher Rorden; Fiscal Year: 2007..The present study tests these predictions by converging use of neuropsychology, functional MRI, and transcranial magnetic stimulation in normal observers. ..
- Epidemiology of IGF and Cardiovascular EventsRobert Kaplan; Fiscal Year: 2005....
- COCAINE EXPOSURE IN UTERO--ELEMENTARY SHCOOL FOLLOWUPDeborah Frank; Fiscal Year: 1999..This data can inform public policy choices for care of cocaine exposed elementary school children nationwide. ..
- Hyperhomocysteinemia in Alzheimer's DiseaseRamon Diaz Arrastia; Fiscal Year: 2003..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
- PROGNOSIS OF CHILDREN WITH A FIRST UNPROVOKED SEIZUREShlomo Shinnar; Fiscal Year: 2002....
- Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and InsulinBrian G Harbrecht; Fiscal Year: 2010..By defining these mechanisms, we will provide a framework for understanding the basic cellular events in shock and sepsis, which may lead to novel cellular-based therapies for critically ill patients. ..
- NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTINGJohn Roback; Fiscal Year: 2004..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
- Plasminogen activators and NMDA after brain injuryWilliam Armstead; Fiscal Year: 2009..Immunohistochemistry, detection of plasminogen activator and MAPK expression, and CBF determination by radiolabled microspheres will be performed. ..
- MOLECULAR ANALYSIS OF MYOTONIC DYSTROPHYSATYAKAM BHAGWATI; Fiscal Year: 2002..This approach is designed to explore the function of these CTG/CUG repeat binding proteins and their possible role in the pathogenesis of DM. ..
- Adverse effects of RBC transfusions: A unifying hypothesisJohn Roback; Fiscal Year: 2009..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..
- Immune Reactants, Cholesterol and AtherosclerosisALLISON REISS; Fiscal Year: 2006..abstract_text> ..
- Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantationJohn Roback; Fiscal Year: 2006....
- POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAINWilliam Armstead; Fiscal Year: 2005..These studies may lead to therapies for brain injured children. ..
- Plasminogen activators and cerebral ischemic injuryWilliam Armstead; Fiscal Year: 2007....