intracranial hemorrhages

..We aimed to correlate plasmatic MMP levels with the appearance of intracranial bleeding complications in stroke patients treated with t-PA...

..We investigated whether high plasma levels of c-Fn were associated with hemorrhagic transformation (HT) after treatment with tissue plasminogen activator (tPA) in patients with acute stroke...

..In patients with pontine hemorrhage (PH), an accurate prognostic assessment is critical for establishing a reasonable therapeutic approach...

..We aimed to study plasma VAP-1/SSAO activity in relation to the risk for intracranial bleeding complications in patients with stroke treated with tissue plasminogen activator (tPA), the greatest safety concern with this treatment...

..Late-type VKDB has particular importance due to frequent intracranial hemorrhages that lead to high mortality and morbidity...

..Moreover, early performance of Kasai portoenterostomy is possible even for patients who have undergone craniotomy...

BACKGROUND AND PURPOSE: Primary pontine hemorrhage (PPH) accounts approximately for about 5-10% of intracranial hemorrhages, and PPHs are known to have a much less uniform prognosis...

..The first episode of hemorrhage in patients with brainstem cavernous malformations is usually benign. Pontine hemorrhage associated with prior hypertension is much more devastating...

..Animal model of stroke can also provide valuable information on genetic factors involved in stroke predisposition. In this review, the focus lies on monogenic forms of stroke that can serve as models to study the more common phenotypes...

....

..While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the relative contribution of neutrophils to the MMP activity and to the development of hemorrhagic transformation remains unknown...

....

..To investigate the cause of intracranial hemorrhage among full-term infants...

....

..Further investigation may determine whether hPMHs portend future symptomatic primary pontine hemorrhages...

..Cerebral microbleeds (MBs) detected on gradient echo (GRE) imaging may be a risk factor for hemorrhagic complications in patients with stroke treated with IV tissue plasminogen activator (tPA)...

..Intracerebellar hemorrhage is a rarely confirmed diagnosis in preterm infants in comparison to peri-/intraventricular hemorrhage. This study evaluates the incidence of intracerebellar hemorrhage and neurological outcome in preterm infants...

..CONCLUSION: CNS score and CT appearance of hematoma are the best predictors of 3 month outcome following thalamic hemorrhage. The proposed model for outcome assessment is simple and easy to apply and could have wide clinical application...

..Stroke occurs relatively frequently (incidence almost 3%) after BMT, has a relatively high frequency of infection-triggered events, has a neurological outcome not easily predicted from available data and is often fatal...

..This pattern leads us to implicate local trauma with contusion or venous compression or occlusion in the development of these hemorrhages...

..To retrospectively evaluate the prevalence of neonatal intracranial hemorrhage (ICH) and its relationship to obstetric and neonatal risk factors...

..We sought to evaluate predictors of clinical outcome, angiographic success, and adverse effects after intra-arterial administration of urokinase for acute ischemic stroke...

..Blood pressure is an important risk factor for stroke, but the roles of serum total and HDL cholesterol, alpha-tocopherol, and beta-carotene are poorly established. We studied these factors in relation to stroke subtypes...

..The ability to correlate blood-borne protein biomarkers with stroke phenotypes would aid in the development of such rapid tests...

..We conclude that neonatal temporal lobe hemorrhagic infarct secondary to suspected superficial temporal venous thrombosis appears to have a good clinical outcome. This is surprising, given the dramatic imaging and clinical presentations...

Recent reports have indicated that cerebral microbleeds (CMBs) detected on gradient-echo (GRF) magnetic resonance imaging may be a risk factor for therapy related intracranial hemorrhages (ICHs).

..Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse...

....

..The odds of ultrasonically detectable brain abnormalities, however, did not increase with increasing latency...

..Finally, because of the neurotrophic role putatively played by S100B, its measurement in biological fluids at pre-/perinatal ages makes it a candidate for the laboratory evaluation of brain maturation...

..We studied the effects of hemoglobin-based oxygen-carrying (HBOC)-201 solution compared with lactated Ringer (LR) solution in a large animal model of brain injury and hemorrhage, in a blinded prospective randomized study...

..To evaluate the respective value of 5 MR sequences to distinguish between stroke patients with and without acute intracerebral hemorrhage (ICH)...

..Multifocal bleeding is the most common form of ICH. Because subarachnoid and subdural space are not easy visible by head ultrasound, the CT or MRI scans are recommended in babies with ICH...

..Aggressive care is justified in patients who do not continue to deteriorate neurologically. Pulmonary complications are frequent but treatable. Early tracheostomy can shorten ICU and hospital stays and reduce costs...

..Our goal was to compare the sensitivity of CT and three MR sequences in detecting and categorizing early (48 hours) hemorrhagic transformation (HT) in hyperacute ischemic stroke...

..We aimed to prospectively compare CT and MRI for emergency diagnosis of acute stroke...

....

..Its severity in massive hemispherical hematomas was due to compression of the brain trunk. CONCLUSION: Pathogenesis of cerebrocardial syndrome rests on impaired central autonomic regulation occurring in stroke...

..The authors emphasize the risk of re-anticoagulation without postoperative imaging and the disadvantages of therapeutic dose, low molecular weight heparin in the postoperative period...

..We conclude that CDH repair on ECMO is technically feasible, shows similar survival to the Extracorporeal Life Support Organization (ELSO) registry, and is associated with few bleeding complications...

..To investigate risk factors, stroke pattern and outcome in stroke patients with cancer...

..1 mm CCA-IMT increase was 1.29 (95% CI: 1.03-1.61). The present results demonstrate the possible predictive power of non-invasive measurement of the CCA-IMT with respect to BI versus ICH and deserve further investigation...

..Giving priority to new large randomized controlled trials is essential to achieve this knowledge...

..79 (95% Cl = 0.73-0.84). Thus to conclude, if substantiated by further validation, this scorincy system can be used to predict haemorrhagic stroke, thereby helping to devise effective risk factor intervention strategy...

..Diagnosis is with computed tomography and magnetic resonance imaging. We present a spontaneous posterior fossa subdural hematoma in a term neonate and discuss conservative management...

..The aim of this work is presentation of our results of surgical treatment of AVM and comparison with the results of radiosurgical and endovascular treatment presented by other authors in the literature...

..Our understanding of the pathogenesis, prevention, and management of these lesions is constantly developing...

..These patients have only been assessed when sitting. We investigated the hypothesis that postural changes modulate visuohaptic SV deviation...

..The purpose of this study was to examine a consecutive series of children with TBI and compare the incidence of complications after placement of an EVD, a fiberoptic intraparencyhmal monitor, or both...

..Treatment of sub-24-hour stroke with abciximab improves early post-treatment neurologic status and often attenuates ischemic lesion growth...

....

..Little is known about subtypes of stroke in lupus...

..To describe a technique of decompressive craniotomy with cystoperitoneal shunt (CPS) placement for treatment of canine intracranial arachnoid cyst (IAC), and to evaluate outcome in 4 dogs...

..This study was carried out to compare clinical diagnosis of stroke with Computed tomography (CT) scan findings in ascertaining the type of stroke (hemorrhagic or ischemic)...

..Further studies to characterize the associated risks of cerebral microhemorrhages in different stroke populations are needed to use this new imaging marker in therapeutic decisions...

..A neonate with severe haemophilia B was treated successfully with recombinant FIX through continuous infusion. A high rate of infusion was required and no complications were noted...

..The PROACT II trial showed that intra-arterial thrombolysis (IAT) is effective for treatment of acute ischaemic stroke attributable to M1 and M2 segment occlusions. Incidence of symptomatic intracranial haemorrhage (sICH) was 10%...

..During a follow-up period of 12 years the neurological and psychological development of the boy has been indistinguishable to that of his twin brother, indicating the satisfactory outcome of the treatment...

..Current guidelines regarding the application of these neuroimaging methods to the premature infant are discussed...

..This review briefly describes the epidemiology, risk factors, evaluation, treatment, and outcome of stroke in children...

..Other investigated parameters were not linked with a fatal outcome...

..Routine surveillance for mycotic aneurysms in patients with new neurologic deficits, and the use of aspirin, should be considered in the medical management...

..9+/-8.7) and 6 (50%) had an NIHSS < or =4 at discharge. CONCLUSIONS: Multimodal rescue therapy was effective at recanalizing occluded cerebral vessels that failed thrombolysis without an excess risk of ICH...

..The treatment of stroke is largely for stabilization of the patient, but it is very important to know the cause to prevent future strokes. Use of heparin in ischemic stroke is very promising and thrombolytic therapy is under trial...

..We evaluated whether children who receive a diagnosis of stroke meet a major inclusion criterion for such trials, namely time to diagnosis of <3 to 6 hours...

....

....

..In the first case definite closure of a remnant of the fistula was refused, in the second no further therapy was recommended...

....

..Present knowledge about the natural history of these lesions is limited, however. We investigated the incidences of intracranial hemorrhage, progressive dementia syndrome, and death in patients diagnosed in our neurovascular center...

..To compare the rate of ischemic events and intracranial hemorrhage in the long-term follow-up of patients with persistent and transient severe stenosis or occlusion of the internal carotid artery (ICA) due to spontaneous dissection (ICAD)...

..6%; P=0.001; odds ratio, 2.0; 95% CI, 1.33 to 3.0). CONCLUSIONS: IAT for ischemic stroke appears efficacious but carries an increased risk of SICH. Further prospective studies are needed to prove the safety and efficacy of IAT in stroke...

..On the basis of this series we found screening to be safe and effective in recognizing ICH. As a result of this approach, all ICHs were found when they were radiographically small and before the babies had neurologic symptoms...

..This prompt treatment will increase the chances of a better prognosis. Another impact measure consists in the administration of the deficient coagulation factor after every head trauma, even when considered minor...

..Timely diagnosis and aggressive surgery may be required for the management of neonatal AVMs with intracerebral hemorrhage...

..The more facile emergency physicians are at interpreting the head CT, the better they can communicate with consulting specialists and deliver prompt care to patients that present with neurologic emergencies...

..This study is the first retrospective analysis of a two-institution experience with IA thrombolysis within 3 hours of stroke onset...

..Mortality (25%, 8/32) and morbidity were considerable, particularly in infratentorial haemorrhages, in aneurysms, in children younger than 3 years and in those with underlying haematological disorders...

..The object of this study is to demonstrate the delayed occurrence of aqueductal stenosis in preterm infants who have suffered from intraventricular hemorrhage (IVH) and to try to explain the mechanisms of this stenosis...

..The mean score of the visual numerical scale was 5.6. The lesions involved the dorsal part of the posterior limb of the internal capsule, probably damaging the thalamocortical sensory pathway...

..Mortality after stroke in children ranges from 20% to 30% depending on the location and the underlying cause. Residual neurological dysfunction is present in more than 50% of survivors...

..There are two forms, the iso-aloimmune forms, with an incidence of intracranial hemorrhage (ICH) in the neonatal period of 10-20%, and the autoimmune form with an incidence of only 1%...

..South Med J 1994;87(2):174-8; Smith RW, Nelson DR. Fractures and other injuries from falls after an ice storm. Am J Emerg Med 1998;16(1):52-5]. We postulated that injuries might differ in a region where ice storms are less common...

..aspects, multiple or complex skull fractures, depression fractures, additional fractures of the body, and intracranial hemorrhages as a consequence of an impact are the most important findings in child abuse...

..ECASS, showed a favorable tendency in the evolution of the treated group, with no increase in symptomatic intracranial hemorrhages. Neuroprotectors have shown to be effective in experimental models of ischaemia but at the moment there ..

..identify the demographic, physiologic, and anatomic variables associated with outcomes of patients with intracranial hemorrhages. We performed a prospective study of all patients with known or suspected intracranial hemorrhages ..

..The aim of this study was to analyze and refine the existing Boston criteria in patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type...

..The study was limited to "standard-risk" patients, who were defined as women with documented alloimmune thrombocytopenia who had not delivered an infant with an intracranial hemorrhage in a prior pregnancy...

..In an attempt to better allocate scarce resources, we hypothesized that not only was repeat head CT unnecessary but also routine intensive care unit (ICU) monitoring of these patients with MBI and stable examinations were unnecessary...

..However, IAT may increase the risk of surgical bleeding. We sought to determine the safety of postoperative IAT...

..To our knowledge, no case report such as this has been found in the medical literature...

..To evaluate the activity and toxicity of carmustine (BCNU) and cisplatin administered as a 72-hour continuous intravenous infusion before radiation in adults with newly diagnosed high-grade astrocytomas...

..epilepsy of approximately 50%, whereas nonpenetrating head injury may produce focal contusions and intracranial hemorrhages, and is associated with a risk of posttraumatic epilepsy of up to 30%...

..We sought to assess nitrogen balance in patients with acute stroke and to determine the variables associated with negative nitrogen balance...

..Selective delivery of calcium channel blocker may improve perfusion and possibly provide neuroprotection in cerebral ischemia...

..We sought to report the occurrence and risk factors of intracranial hemorrhage during long-term follow-up of patients with internal carotid artery stenosis, with and without carotid endarterectomy...

..should be used to prevent VTE complications, but suggest that there is an increased risk of expansion of intracranial hemorrhages (ICH) with VTE prophylaxis. In addition, it is unclear which treatment regimen (i.e...

..1 mg/kg and 0.4 mg/kg without any symptomatic intracranial hemorrhages being observed...

Brain arteriovenous malformations (BAVM) are usually detected only when the patient presents with intracranial hemorrhages, seizures, headaches, focal neurological deficits, or other disorders. A smaller number are detected incidentally...

..Hence, the proposed study will elucidate the mechanism of white matter injury in IVH and may lead to novel strategies in prevention of cerebral palsy in premature infants. ..

..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. ..

..Dr. James Bussel, as our site's Primary Investigator, is responsible for ensuring that all aspects of TMH Network protocols are followed. WEILL CORNELL MEDICAL CENTER/NEW YORK PRESBYTERIAN HOSPITAL CRITIQUES ..

..Together, these projects will provide practical experience and form the basis for future studies that seek to improve the safety and use of anticoagulants in the oldest patients with atrial fibrillation. ..

..This project will evaluate current treatment patterns for VTE, identify risk factors for adverse outcomes, and develop clinically applicable risk-stratification tools to help predict recurrent VTE and major hemorrhagic complications. ..

..Therapies that restore blood flow to more patients, and do so more effectively and safely, are greatly needed to improve outcomes after stroke. ..

..comparison of the quality of anticoagulation provided by anticoagulation units versus that of primary physicians. The investigators state that this research should lead to important health and economic benefits for older Americans. ..

..We believe our planning process is specific, innovative yet disciplined, and should be robust. A full and competitive CTSA application will be produced in a timely manner. ..

..In all, continued study of our cohort will efficiently provide powerful insights into optimizing stroke prevention strategies for the many older Americans with AF. ..

..Thus, we request funding to study the genomic of migraine using a whole genome approach and to evaluate gene-environment interactions. ..

..Thus, this grant proposal request funding to study the association between RLS, CVD risk factors as well as CVD events. ..

..Thus, we request funding to study the genomic of migraine using a whole genome approach and to evaluate gene-environment interactions. ..

..Thus, this grant proposal request funding to study the association between RLS, CVD risk factors as well as CVD events. ..

..g., lipids) over time due to changes in HAART and HIV disease stage, and how this impacts atherosclerosis. (End of Abstract) ..

....

....

..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..

....

..Effect of Erythropoietin on Anemia and Need for Transfusion Project 3. EDHF Following Traumatic Brain Injury Project 4. Neuroprotection of Erythropoietin Signaling in TBI ..

..In turn, this may open up avenues for therapeutic manipulation of deleterious gene expression in human patients. ..

..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..

..The present study tests these predictions by converging use of neuropsychology, functional MRI, and transcranial magnetic stimulation in normal observers. ..

..Such data can inform clinical interventions and public policy choices for care of youngsters with IUCE from infancy to adolescence. ..

..This data can inform public policy choices for care of cocaine exposed elementary school children nationwide. ..

....

..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..

..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..

..Immunohistochemistry, detection of plasminogen activator and MAPK expression, and CBF determination by radiolabled microspheres will be performed. ..

..abstract_text> ..

..In view of clinical studies demonstrating successful cerebral arterial recanalization, the approaches in this proposal may have significant consequences for future acute stroke patient management and outcome...

..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..

..By defining these mechanisms, we will provide a framework for understanding the basic cellular events in shock and sepsis, which may lead to novel cellular-based therapies for critically ill patients. ..

..Immunohistochemistry, detection of plasminogen activator and MAPK expression, and CBF determination by radiolabled microspheres will be performed. ..

..These studies may lead to therapies for brain injured children. ..

..This approach is designed to explore the function of these CTG/CUG repeat binding proteins and their possible role in the pathogenesis of DM. ..

..abstract_text> ..

..Understanding the mechanisms of their expression and disruption is likely to lead to new testable approaches to preserve or selectively alter barrier function and microvessel integrity in other neurovascular degenerative disorders. ..

..These studies are likely to lead to new testable therapeutic approaches to preserve mlcrovascular and neuron function which will have relevance to other vascular neuron degenerative disorders. ..

..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..

....

..These insights will contribute to uncovering the basic cellular mechanisms involved in multiple organ dysfunction and may lead to potential therapeutic approaches. ..

....

....

..g., lipids) over time due to changes in HAART and HIV disease stage, and how this impacts atherosclerosis. (End of Abstract) ..