Genomes and Genes
Summary: The formation of an area of necrosis in the cerebrum caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Publications395 found, 100 shown here
- Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effectsMervyn D I Vergouwen
Department of Medicine, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Stroke 42:924-9. 2011..Our aim was to clarify the relationship among angiographic vasospasm, neurological worsening, cerebral infarction, and poor outcome and to investigate whether cerebral infarction also contributes to poor outcome by ..
- Toll-like receptor 4 is involved in brain damage and inflammation after experimental strokeJavier R Caso
Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain
Circulation 115:1599-608. 2007..We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway...
- 1H-NMR-based metabolomics study of cerebral infarctionJee Youn Jung
Korea Basic Science Institute, Seoul, 136 713, Korea
Stroke 42:1282-8. 2011..Thus, we applied a 1H-NMR metabolomics approach to investigate the altered metabolic pattern in plasma and urine from patients with cerebral infarctions and sought to identify metabolic biomarkers associated with stroke...
- Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatmentsAlessandra Del Bene
Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy
Int J Stroke 7:321-9. 2012..Moreover, based on putative mechanisms and suggestions from reported evidence, we propose a few treatments that seem worthy to be tested by randomized clinical trials...
- Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase geneC Iadecola
Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 17:9157-64. 1997..iNOS inhibition may provide a novel therapeutic strategy targeted specifically at the secondary progression of ischemic brain injury...
- Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarctionNami Nakagomi
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
Stem Cells 27:2185-95. 2009..These data indicate that reconstitution of elements in the vascular niche enhances transplantation of adult neural progenitor cells...
- Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarctionJens H Jensen
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016 3295, USA
NMR Biomed 24:452-7. 2011..It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum...
- Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhageR Webster Crowley
Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
Stroke 42:919-23. 2011The long-standing concept that delayed cerebral infarction after aneurysmal subarachnoid hemorrhage results exclusively from large artery vasospasm recently has been challenged...
- Cerebral small-vessel disease and decline in information processing speed, executive function and memoryNiels D Prins
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
Brain 128:2034-41. 2005..Our results suggest that in older people cerebral small-vessel disease may contribute to cognitive decline by affecting information processing speed and executive function...
- Incidence and short-term outcome of cerebral infarction in young adults in western NorwayH Naess
Department of Neurology, Haukeland Hospital, University of Bergen, Bergen, Norway
Stroke 33:2105-8. 2002We sought to determine the incidence and short-term outcome of people aged 15 to 49 years with first-ever cerebral infarction in 1988-1997 in Hordaland County, Norway.
- Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarctionJ M Schwab
Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
Neuropathol Appl Neurobiol 26:434-40. 2000..study reports CTGF expression by cells associated with matrix deposition and glial scar formation in human cerebral infarction. CTGF was localized by immunohistochemistry in 17 brains of patients after focal infarction and in three ..
- Polymorphism of apolipoprotein A5 is a risk factor for cerebral infarction in type 2 diabetesXuefeng Li
Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China
J Huazhong Univ Sci Technolog Med Sci 28:653-6. 2008..investigated the association of apolipoprotein A5 (apoA5) gene polymorphism at position -1131T>C with cerebral infarction in patients with type 2 diabetes...
- Impairment of cerebral perfusion and infarct patterns attributable to vasospasm after aneurysmal subarachnoid hemorrhage: a prospective MRI and DSA studyStefan Weidauer
Institute of Neuroradiology, University of Frankfurt, Frankfurt, Germany
Stroke 38:1831-6. 2007..The objective of this study was to investigate disturbance of perfusion and infarct patterns attributable to cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH)...
- Physical exercise induces expression of CD31 and facilitates neural function recovery in rats with focal cerebral infarctionXiquan Hu
Department of Rehabilitation Medicine, Second Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, China
Neurol Res 32:397-402. 2010..The present study was aimed at examining the role of physical exercise in the improvement of damaged neural function and the induction of angiogenesis...
- Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarctionShihui Xing
Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
Autophagy 8:63-76. 2012b>Cerebral infarction can cause secondary degeneration of thalamus and delay functional recovery. However, the mechanisms underlying secondary degeneration are unclear...
- Relative elevation in baseline leukocyte count predicts first cerebral infarctionM S V Elkind
Department of Neurology, Columbia University College of Physicians and Surgeons, Joseph Mailman School of Public Health, New York, NY, USA
Neurology 64:2121-5. 2005..Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease...
- An optimized triphenyltetrazolium chloride method for identification of cerebral infarctsChintamani Narasinh Joshi
Division of Toxicology, Central Drug Research Institute, Chattar Manzil, P O Box 173, Lucknow, UP 226 001, India
Brain Res Brain Res Protoc 13:11-7. 2004..05% TTC provided improved delineation of brain infarcts, reduced 'nonspecific' staining of white matter and the infarct size correlated well with that measured after 1% TTC staining; the method also reduces the costs to 1/20...
- Neuroprotection in cerebral infarction: the opportunity of new studiesNatalia Perez de la Ossa
Stroke Unit, Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
Cerebrovasc Dis 24:153-6. 2007..A better understanding of ischemic and restorative brain mechanisms beyond the acute phase of stroke may open new therapeutic options to improve stroke recovery...
- Non-linear association between ankle-brachial pressure index and prevalence of silent cerebral infarction in Japanese patients with type 2 diabetesRyotaro Bouchi
Division of Nephrology and Hypertension, Diabetes Center, Tokyo Women s Medical University School of Medicine, 8 1 Kawadacho, Shinjukuku, Tokyo 162 8666, Japan
Atherosclerosis 222:490-4. 2012..We aimed to reveal whether ABI abnormality, especially high ABI is associated with prevalent silent cerebral infarction (SCI) in type 2 diabetic patients.
- Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarctionKazuo Yano
Laboratory for Pharmacology, Asahi Kasei Pharma, Shizuoka, Japan
Eur J Pharmacol 594:77-83. 2008Evidence that Rho-kinase is involved in cerebral infarction has accumulated. However, it is uncertain whether Rho-kinase is activated in the brain parenchyma in cerebral infarction...
- Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietinYun Xia Li
The Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China
Neurosci Bull 24:89-95. 2008..To investigate whether desferoxamine (DFO) preconditioning can induce tolerance against cerebral ischemia and its effect on the expression of hypoxia inducible factor 1alpha (HIF-1alpha) and erythropoietin (EPO) in vivo and in vitro...
- Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stressYukihito Higashi
Hiroshima University, Graduate School of Biomedical Sciences, Department of Cardiovascular Physiology and Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Expert Opin Pharmacother 10:323-31. 2009..therapeutic strategy for the prevention of brain injury and reduction of mortality in patients with acute cerebral infarction. A combination of established thrombolytic therapy and effective neuronal protection therapy has more ..
- Lactococcus garvieae endocarditis with initial presentation of acute cerebral infarction in a healthy immunocompetent manWei Kai Li
Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
Intern Med 47:1143-6. 2008..We present a case study of a 41-year-old man with infective endocarditis caused by L. garvieae which is the first reported case with initial presentation as acute cerebral infarction.
- Diffuse cerebral intravascular coagulation and cerebral infarction in pneumococcal meningitisMervyn D I Vergouwen
Department of Neurology, H2 259, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
Neurocrit Care 13:217-27. 2010There is a widely held belief that cerebral infarction after bacterial meningitis is always caused by vasculitis; however, evidence is weak...
- Hypothermic protection in rat focal ischemia models: strain differences and relevance to "reperfusion injury"Yubo Ren
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Cereb Blood Flow Metab 24:42-53. 2004....
- Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndromeYoshiji Yamada
FAHA, Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Mie 514 8507, Japan
Int J Mol Med 21:801-8. 2008..aim of the present study was to identify genetic variants that confer susceptibility to atherothrombotic cerebral infarction among individuals with metabolic syndrome in order to allow prediction of genetic risk for this condition...
- Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam studyM Hollander
Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, and Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands
Circulation 105:2872-7. 2002..and limited data exist on the importance of location of plaques or the association with subtypes of cerebral infarction. We investigated the relationship between carotid plaques, measured at different locations, and risk of ..
- Predictors of cerebral infarction in aneurysmal subarachnoid hemorrhageAlejandro A Rabinstein
Neurological Neurosurgical Intensive Care Unit and the Department of Neurology, Rochester, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Stroke 35:1862-6. 2004Clinical and radiologic predictors of cerebral infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied.
- Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampusTong Wang
Molecular Biology Laboratory, Acupuncture and Moxibustion Research Institute, The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Physiol Behav 96:155-61. 2009..The result of the research suggested that acupuncture can exert antiapoptotic effect through counter-regulating Bcl-2 and Bax gene expression...
- Vascular syndromes of the thalamusJeremy D Schmahmann
Department of Neurology, VBK 915, Massachusetts General Hospital, Fruit St, Boston, MA 02114, USA
Stroke 34:2264-78. 2003..This article reviews the anatomy, connections, and functions of the thalamic nuclei, their vascular supply, and the clinical syndromes that result from thalamic infarction...
- Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion modelMing Zhang
Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Cereb Blood Flow Metab 27:1387-96. 2007..Administration of the selective CB(2) agonists significantly decreased cerebral infarction (30%) and improved motor function (P<0.05) after 1 h MCAO followed by 23 h reperfusion in mice...
- Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesionsYsbrand D Van Der Werf
Department of Anatomy and Embryology, Graduate School for Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Neuropsychologia 41:1330-44. 2003..Separate thalamic structures are involved in memory, executive functioning and attention...
- Fatigue at long-term follow-up in young adults with cerebral infarctionHalvor Naess
Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway
Cerebrovasc Dis 20:245-50. 2005..To study the impact of fatigue in young ischaemic stroke patients...
- Patterns of cerebral infarction in aneurysmal subarachnoid hemorrhageAlejandro A Rabinstein
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Stroke 36:992-7. 2005..The aim of this study was to analyze the distribution patterns of delayed cerebral ischemia after subarachnoid hemorrhage (SAH) and the factors that determine their occurrence...
- Specific caspase pathways are activated in the two stages of cerebral infarctionA Benchoua
, , , France
J Neurosci 21:7127-34. 2001..We show that in the early stages of cerebral infarction, neurons of the so-called "necrotic" core display a number of morphological, physiological, and ..
- Early hemicraniectomy in patients with complete middle cerebral artery infarctionS Schwab
Department of Neurology, University of Heidelberg, Germany
Stroke 29:1888-93. 1998..Several reports indicate a beneficial effect of hemicraniectomy in this situation. However, whether and when decompressive surgery is indicated in these patients is still a matter of debate...
- Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health StudyW T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Arch Neurol 55:1217-25. 1998..To identify risk factors for and functional consequences of lacunar infarct in elderly people...
- Cerebral infarction in eclampsiaGerda G Zeeman
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Tex, USA
Am J Obstet Gynecol 190:714-20. 2004..This study was undertaken to characterize the neuroimaging findings of cerebral edema associated with eclamptic seizures by use of diffusion-weighted magnetic resonance imaging (MRI)...
- Advanced glycation end products in patients with cerebral infarctionYuko Ohnuki
Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan
Intern Med 48:587-91. 2009..In this study, we determined skin AGEs in patients with cerebral infarction.
- The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cellsKiyoshi Kikuchi
Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Science, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
J Pharmacol Exp Ther 329:865-74. 2009Edaravone, a potent free radical scavenger, is clinically used for the treatment of cerebral infarction in Japan...
- Risk factors for posttraumatic cerebral infarction in patients with moderate or severe head traumaHeng Li Tian
Department of Neurosurgery, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
Neurosurg Rev 31:431-6; discussion 436-7. 2008We examined the incidence and timing of posttraumatic cerebral infarction (PTCI) and provide predictive factors for the development of PTCI in patients with moderate or severe traumatic brain injury...
- TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarctionHiroyasu Akatsu
Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441 8914, Japan
Br J Haematol 127:440-7. 2004..We investigated whether these TAFI polymorphisms would act as a risk factor for cerebral infarction (CI) by examining 253 samples in which the diagnosis was cliniconeuropathologically confirmed...
- Mouse model of in situ thromboembolic stroke and reperfusionCyrille Orset
INSERM Avenir tPA in the working brain, University of Caen, Centre Cyceron, Bd Becquerel, BP 5229, 14074 Caen Cedex, France
Stroke 38:2771-8. 2007..As such, one is forced to consider that new animal models of focal cerebral ischemia may be required before clinical evaluation of a new molecule...
- An efficient framework for estimation of muscle fiber orientation using ultrasonographyShan Ling
The Shenzhen Key Laboratory for Low cost Healthcare, Shenzhen, China
Biomed Eng Online 12:98. 2013..The traditional manual method for MFO estimation in sonograms was labor-intensive. The automatic methods proposed in recent years also involved voting procedures which were computationally expensive...
- Impact of systemic inflammatory response syndrome on vasospasm, cerebral infarction, and outcome after subarachnoid hemorrhage: exploratory analysis of CONSCIOUS-1 databaseAlan K H Tam
Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
Neurocrit Care 13:182-9. 2010..associated with SIRS after SAH, whether SIRS was associated with complications of SAH such as vasospasm, cerebral infarction, and clinical outcome, and whether SIRS could contribute to a difference in outcome between patients ..
- Increased oxidative stress is responsible for severer cerebral infarction in stroke-prone spontaneously hypertensive ratsXiu Hua Zhang
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
CNS Neurosci Ther 17:590-8. 2011To examine the role of increased oxidative stress in the pathogenesis of cerebral infarction in stroke in stroke-prone spontaneously hypertensive rats (SHR-SP).
- Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging studyKai Lin
Department of Radiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, and Beijing Anzhen Hospital, Anzhen Li, Chaoyang District, Beijing 100029, China
Acad Radiol 13:1180-6. 2006....
- The functional anatomy of single-word reading in patients with hemianopic and pure alexiaA P Leff
MRC Clinical Sciences Centre, Cyclotron Unit, Hammersmith Hospital, London W12 0NN, UK
Brain 124:510-21. 2001..The relative contributions of pure and hemianopic alexia in individual patients needs to be assessed, as the latter has been shown to respond well to specific rehabilitation programmes...
- Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysisYu Yo Sun
Division of Developmental Biology, Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, United States
J Neurosci Methods 203:122-9. 2012A simple method to quantify cerebral infarction has great value for mechanistic and therapeutic studies in experimental stroke research...
- Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injuryP Zhang
Department of Anesthesiology, Second Affiliated Hospital of Xi an Jiaotong University School of Medicine, 157 West 5 road, Xi an, Shaanxi 710004, China
Neuroscience 201:297-306. 2012Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction. However, its effect on stroke-induced subventricular zone (SVZ) neurogenesis is largely unknown...
- Imaging corticospinal degeneration in neonatal rats with unilateral cerebral infarctionS Lama
Medical Science, Faculty of Medicine, University of Calgary
Exp Neurol 228:192-9. 2011..This demonstrates directly the utility of ADC and T(2) MRI to detect acute changes in axons associated with early Wallerian degeneration...
- Electroacupuncture enhances motor recovery performance with brain-derived neurotrophic factor expression in rats with cerebral infarctionMin Wook Kim
Institute of Catholic Integrative Medicine, Incheon St Mary s Hospital, Catholic University, Seoul, Korea
Acupunct Med 30:222-6. 2012..Brain-derived neurotrophic factor (BDNF) is a potent growth factor involved in recovery following cerebral injury. The aim of the present study was to investigate whether EA increases BDNF levels and facilitates functional recovery...
- Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiencyK Murakami
CNS Injury and Edema Research Center, Department of Neurological Surgery, University of California, School of Medicine, San Francisco, California 94143 0651, USA
J Neurosci 18:205-13. 1998..The present study suggests that O2- overproduced in a mitochondrial compartment, when uncoupled from antioxidant defenses, induces impairment of mitochondrial function and causes exacerbation of cerebral infarction after ischemia.
- Transneuronal retrograde degeneration of the retinal ganglion cells in patients with cerebral infarctionHae Young Lopilly Park
Department of Ophthalmology and Visual Science, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Ophthalmology 120:1292-9. 2013..In addition, whether laterality and severity of retinal nerve fiber layer (RNFL) damage correlated with 3 other variables was determined: laterality of hemispheric damage, arterial territory of infarct, and age of infarct...
- Effects of transcranial direct current stimulation on hemichannel pannexin-1 and neural plasticity in rat model of cerebral infarctionT Jiang
Department of Neurology, the Third Affiliated Hospital of Southern Medical University, NO 183, Zhongshan Road West, Guangzhou 510630, China
Neuroscience 226:421-6. 2012..0001). Cerebral infarction induced increased PX1 mRNA expression on days 3, 7, and 14 (P<0...
- Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarctionJinkwon Kim
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
Thromb Haemost 108:349-56. 2012..We investigated whether RDW in acute cerebral infarction is predictive of functional outcome and mortality...
- Association of extracellular superoxide dismutase gene with cerebral infarction in women: a haplotype-based case-control studyTakahiro Naganuma
Division of Molecular Diagnostics, Department Advanced Medical Science, Nihon University School of Medicine, Tokyo, Japan
Hereditas 145:283-92. 2008It has been reported that oxidative stress is a factor in cerebral infarction (CI)...
- Dietary pattern, nutritional density, and dietary quality were low in patients with cerebral infarction in KoreaHyunjung Lim
Department of Medical Nutrition, Graduate School of East West Medical Science, Kyung Hee University, Yongin, Republic of Korea
Nutr Res 31:601-7. 2011The aim of this study was to examine if the dietary quality of patients with cerebral infarction (CI) was comparatively worse than those of non-CI subjects in Korea...
- Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohortDomenico Inzitari
Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Firenze, Italy
BMJ 339:b2477. 2009..To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes...
- Cerebral infarction associated with acute subarachnoid hemorrhageJ Michael Schmidt
Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neurocrit Care 7:10-7. 2007b>Cerebral infarction is a common complication of aneurysmal subarachnoid hemorrhage (SAH), but usually occurs several days after onset as a complication of vasospasm or aneurysm repair...
- Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in ratsB Lei
Department of Anesthesiology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Neuroscience 125:691-701. 2004..These findings suggest that lidocaine attenuates apoptosis in the penumbra after transient focal cerebral ischemia. The infarct-reducing effects of lidocaine may be due, in part, to the inhibition of apoptotic cell death in the penumbra...
- Decompressive craniectomy in massive cerebral infarctionJoão Paulo Mattos
Neurosurgery Department, UNICAMP, Campinas SP, Brazil
Arq Neuropsiquiatr 68:339-45. 2010..Dominant hemispheric infarction does not represent exclusion criteria...
- Wavelet analysis of cerebral oxygenation signal measured by near infrared spectroscopy in subjects with cerebral infarctionZengyong Li
School of Mechanical Engineering, Shandong University, Jinan, PR China
Microvasc Res 80:142-7. 2010The objective of this study is to assess the cerebral oxygenation oscillations in subjects with cerebral infarction (CI) based on the wavelet transform of near infrared spectroscopy (NIRS) signals...
- Effect of large dose hyperbaric oxygenation therapy on prognosis and oxidative stress of acute permanent cerebral ischemic stroke in ratsLianbi Xue
Department of Hyperbaric Oxygenation, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Neurol Res 30:389-93. 2008..To evaluate the therapeutic effect and the oxidative stress effect of 9 and 18 hour hyperbaric oxygenation therapy (HBOT) protocols on the earliest stage of acute permanent middle cerebral artery occlusion (MCAO) in rats...
- Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in ratsJing Liu
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China
Brain Res 1089:162-70. 2006..Our results demonstrated that PF could attenuate cognitive deficit and brain damage induced by chronic cerebral hypoperfusion and that suppression of neuroinflammatory reaction in brain might be involved in PF-induced neuroprotection...
- In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in miceNing Liu
Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
Brain Res 1397:66-75. 2011....
- Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in ratsYanlin Chen
Department of Pathology, Chongqing Medical University, Chongqing, People s Republic of China
PLoS ONE 7:e40165. 2012..However, little is known about the underlying mechanisms. Here we put forward the hypothesis that TSA acts through inhibition of MIF expression during focal cerebral I/R injury in rats...
- Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY ratsSharon Hom
Dept of Pharmacology, College of Medicine, Univ of Arizona, Tucson, AZ 85724, USA
Am J Physiol Regul Integr Comp Physiol 292:R1881-92. 2007..tight-junction (TJ) and ion transporter proteins critical for maintaining brain homeostasis contribute to cerebral infarction during hypertension development...
- Plasma miR-124 as a biomarker for cerebral infarctionHuachun Weng
Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
Biomed Res 32:135-41. 2011..We examined whether plasma concentrations of brain-specific miRNA can serve as a biomarker for cerebral infarction, where the cerebral infarction was modeled by middle cerebral artery occlusion (MCAO) in the rat...
- Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in ratsS H Fang
Department of Pharmacology, School of Medicine, Zhejiang University, 353 Yanan Road, Hangzhou 310031, China
Neuroscience 140:969-79. 2006..Thus, we conclude that cysteinyl leukotriene receptor 1 mediates acute neuronal damage and subacute/chronic astrogliosis after focal cerebral ischemia...
- Evaluation of admission characteristics, hospital length of stay and costs for cerebral infarction in a medium-sized city in ChinaY Ma
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong Department of Forensic Medicine, North Sichuan Medical College, Nanchong, P R China
Eur J Neurol 17:1270-6. 2010..This study aimed to evaluate hospital length of stay (LOS) by admission characteristics and costs correlated with medical insurance status for cerebral infarction in a medium-sized city in China.
- Functional recovery and expression of GDNF seen in photochemically induced cerebral infarctionKeisuke Horinouchi
Department of Rehabilitation and Physical Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
Int J Neurosci 117:315-26. 2007..However, there have been few reports examining the relationship between GDNF and functional recovery after cerebral infarction. The authors investigated the change in the expression of GDNF proteins during functional recovery in rats ..
- Mild depression in young adults with cerebral infarction at long-term follow-up: a population-based studyH Naess
Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway
Eur J Neurol 12:194-8. 2005..for post-stroke depression (PSD) at long-term follow-up in young adults aged 15-49 years with first-ever cerebral infarction in a population-based study...
- Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control studyZhongxing Peng
Institute of Neurosciences, The Second Affiliated Hospital of Guangzhou Medical College, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Guangzhou 510260, P R China
Lipids Health Dis 10:100. 2011..study was carried out to investigate the possible association of the TGF-β1 gene C-509T and T869C polymorphisms, and their combined genotypes with the risk of atherosclerotic cerebral infarction (CI) in the Chinese population.
- Predictors for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysisFutoshi Anan
Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
Metabolism 56:593-8. 2007..89; 95% confidence interval, 1.57-3.38; P < .005). Our findings indicate that HGF may be a novel useful predictor of SCI in patients with chronic renal failure undergoing HD...
- Alzheimer's disease with and without cerebral infarctsTeodoro Del Ser
Seccion de Neurologia, Hospital Severo Ochoa, Avda Orellana s n, Leganes, 28911 Madrid, Spain
J Neurol Sci 231:3-11. 2005..To compare the clinical and pathological features of Alzheimer's disease (AD) patients with and without associated cerebral infarcts (CI)...
- Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stressKentaro Deguchi
Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
Brain Res 1188:1-8. 2008..b>Cerebral infarction was induced by transient middle cerebral artery occlusion (tMCAO) for 90 min, followed by reperfusion...
- Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell deathThiruma V Arumugam
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 104:14104-9. 2007..Our data suggest a major role for complement-mediated cell death in ischemic brain injury and the prospect of using IVIG in relatively low doses as an interventional therapy for stroke...
- Carotid plaque composition and cerebral infarction: MR imaging studyMohamed Ouhlous
Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
AJNR Am J Neuroradiol 26:1044-9. 2005..We analyzed the relationship between the composition of the atherosclerotic plaque at the carotid artery bifurcation and ipsilateral ischemic cerebral lesions on MR imaging...
- Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhageMervyn D I Vergouwen
Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Cereb Blood Flow Metab 31:1545-53. 2011..It has been suggested that cerebral infarction is a better outcome measure than vasospasm in clinical trials and observational studies...
- Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid systemQiang Wang
Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
Stroke 40:2157-64. 2009..The present study was aimed to investigate the involvement of the endocannabinoid system in the early neuroprotection conferred by EA pretreatment in the animal model of focal cerebral ischemia...
- Shift of motor activation areas during recovery from hemiparesis after cerebral infarction: a longitudinal study with near-infrared spectroscopyKotaro Takeda
Department of Neurology, International University of Health and Welfare Hospital, 537 3 Iguchi, Nasushiobara 329 2763, Japan
Neurosci Res 59:136-44. 2007..24) as motor function recovered. These findings suggest that a transient increase in motor activation in the ipsilateral intact hemisphere within 1 month may play an important role in the recovery from motor dysfunction after stroke...
- Cerebral infarction in autopsies of chagasic patients with heart failureRoque Aras
Universidade Federal da Bahia, Salvador, BA, Brazil
Arq Bras Cardiol 81:414-6, 411-3. 2003..To determine the frequency of encephalic infarction and its contribution to lethality in patients with Chagas' disease and heart failure...
- Long-term outcome of cerebral infarction in young adultsH Naess
Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway
Acta Neurol Scand 110:107-12. 2004We analysed the long-term outcome of 232 young adults aged 15-49 years with first-ever cerebral infarction in 1988-1997 in western Norway.
- Proposal for a universal definition of cerebral infarctionJeffrey L Saver
Stroke Center and the Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
Stroke 39:3110-5. 2008b>Cerebral infarction is a leading cause of disability and death worldwide but has no uniform international definition.
- Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhageSherise Fergusen
Section of Neurosurgery, Department of Surgery, The University of Chicago Medical Center, Pritzker School of Medicine, Chicago, Illinois, USA
Neurosurgery 60:658-67; discussion 667. 2007b>Cerebral infarction would be expected to be associated with poor outcome after aneurysmal subarachnoid hemorrhage (SAH), although there are few data on which to base this assumption...
- Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanismKenichi Mishima
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka City, Fukuoka, Japan
Stroke 36:1077-82. 2005..Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice...
- Relationship between carotid intima-media thickness and silent cerebral infarction in Japanese subjects with type 2 diabetesKazuhiro Nomura
Center for Diabetes and Endocrinology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
Diabetes Care 33:168-70. 2010We examined the relationship between intima-media thickness of common carotid artery (CCA-IMT) and silent cerebral infarction (SCI) with the magnetic resonance imaging (MRI) study in Japanese subjects with type 2 diabetes.
- Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicalsGyung W Kim
Department of Neurosurgery, Stanford University School of Medicine, Stanford, Calif, USA
Stroke 33:809-15. 2002....
- The effect of electro-acupuncture on motor function recovery in patients with acute cerebral infarction: a randomly controlled trialJ Pei
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032
J Tradit Chin Med 21:270-2. 2001The aim of this study is to investigate the effect of electro-acupuncture treatment in acute phase of cerebral infarction on the motor functions...
- Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarctionQing wu Yang
Department of Neurology, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing, China
J Cereb Blood Flow Metab 28:1588-96. 2008..mice, 6 h of cerebral ischemia followed by 24 h of reperfusion did not significantly change cerebral edema, cerebral infarction area, and neurologic impairment scores in MyD88 gene knockout mice...
- Silent infarcts in young children with sickle cell diseaseJanet L Kwiatkowski
Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
Br J Haematol 146:300-5. 2009..The prevalence of silent infarcts in young children with SCD-SS is similar to that of older children and anaemia and severe vasculopathy may be risk factors...
- The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?Dwaine F Emerich
Life Sciences Research and Development, Alkermes, Cambridge, Massachusetts 02139, USA
Exp Neurol 173:168-81. 2002..For this reason we also offer suggestions for additional experiments and the inclusion of control groups that, in the future, might provide more effective or conclusive tests of the hypothesis...
- Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarctionYumi Shimo-Nakanishi
Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Atherosclerosis 175:109-15. 2004..We investigated the association between p22(phox) C242T polymorphism and thrombotic cerebral infarction and the role of this polymorphism on superoxide-production activity in human neutrophils and promyelocytic ..
- Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the ratZhong Pei
University Department of Medicine, Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
Neurosci Lett 318:141-4. 2002..2, 51.2 and 44.5%, respectively. Melatonin did not affect the hemodynamic parameters. Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion...
- Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injuryJun Li
Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Charite University Medicine Berlin, Germany
FASEB J 19:617-9. 2005..Our data indicate that cerebral AT2 receptors exert neuroprotective actions in response to ischemia-induced neuronal injury, possibly by supporting neuronal survival and neurite outgrowth in peri-ischemic brain areas...
- Meta-analysis of association between variation in the PDE4D gene and ischemic cerebral infarction risk in Asian populationsXiaowei Xu
Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
Neurogenetics 11:327-33. 2010..22; 95% CI, 1.03-1.43) and SNP 83 CC genotype (OR, 1.42; 95% CI, 1.14-1.77), but not for SNP 83 CC + CT genotypes or SNP 87. PDE4D was associated with ischemic infarction risk in Asian people, and SNP 83 was an important biomarker...
- Neuropsychology of infarctions in the thalamus: a reviewY D Van Der Werf
Graduate School for Neurosciences, Amsterdam, The Netherlands
Neuropsychologia 38:613-27. 2000..The results indicate that damage to the mediodorsal nucleus of the thalamus, the midline nuclei or the intralaminar nuclei, or a combined lesion of these structures may be responsible for deficits of executive functioning...
- The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley ratsNou Ying Tang
China Medical University, Taichung, Taiwan
Am J Chin Med 38:51-64. 2010..The ratios of cerebral infarction area to total brain area, and neuro-deficit score were used as an index to observe the effects of ..
- Endogenous neurogenesis in the human brain following cerebral infarctionStephen L Minger
Stem Cell Biology Laboratory, Wolfson Centre for Age Related Diseases, King s College London, London, UK
Regen Med 2:69-74. 2007....
- Incidental findings on brain MRI in the general populationMeike W Vernooij
Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
N Engl J Med 357:1821-8. 2007..We conducted a study to determine the prevalence of such incidental brain findings in the general population...
- Deregulated lipid metabolism in strokeRobert J Dempsey; Fiscal Year: 2013..In support of our hypothesis, D609 (a) significantly reduced cerebral infarction at reperfusion days 1 and 3, (b) up-regulated p21 and p27 through ceramide accumulation, and (c) attenuated ..
- Reperfusion and Neurovascular Injury in StrokePak H Chan; Fiscal Year: 2013..to metalloproteinase-9 (MMP-9) activation and BBB disruption that characterize neurovascular injury and cerebral infarction. We have recently discovered that signal transducer and activator of transcription 3 (STAT3) is a ..
- Treatment of stroke with a clinically approved proteasome inhibitorLi Zhang; Fiscal Year: 2012..a proteasome inhibitor, VELCADE, an agent in clinical use for the treatment of cancer, effectively reduces cerebral infarction, and concomitantly reduces secondary thrombosis and microvascular permeability in young rats...
- S-Nitrosylated Hemoglobin and Ischemic Brain InjuryDavid Warner; Fiscal Year: 2010..nitrite inhalation on absolute CBF during and after filament MCAO and measure amount of tissue at risk for cerebral infarction as a function of the fraction of inspired oxygen (Fi02), 2) Define ethyl nitrite efficacy in a long-term ..
- Development of New Molecular Probes for Diagnostic Imaging of AtherosclerosisKAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010..Cardiovascular disease remains the primary cause of mortality in the United States with myocardial and cerebral infarction caused by atherosclerosis accounting for these deaths...
- The role of a novel AIF-associated nuclease PAAN1 in neuronal injuryYingfei Wang; Fiscal Year: 2013..Poly(ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in glutamate neurotoxicity and cerebral infarction, which is a primary cause of subsequent morbidity and mortality following stroke...
- Poly (ADP-Ribose) and AIF in Neuronal InjuryRAYMOND CHARLES KOEHLER; Fiscal Year: 2013..Poly(ADP-ribose) polymerase-1 (PARP-1) is pivotal in glutamate neurotoxicity and cerebral infarction. Prior studies indicate that NO, or peroxynitrite plays a prominent role in glutamate excitotoxicity and ..
- MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIAGregory J del Zoppo; Fiscal Year: 2010..cathepsin and heparanase activities decreases matrix HSPG and HS degradation, and reduces the volume of cerebral infarction. Studies of the contributions of HSPG/HS-degrading proteases to the loss of microvessel integrity and ..
- Cerebral arteriole structure/function in diabetic ischemic brain injuryAdviye Ergul; Fiscal Year: 2013..due to preexisting diabetes or acute stress response is associated with higher incidence and severity of cerebral infarction, edema formation and the risk of hemorrhagic transformation (HT) that develops secondary to AIS ..
- Integrative Genomics of StrokeRose Du; Fiscal Year: 2013..In this proposal, we aim to study the susceptibility to cerebral infarction in the presence of focal cerebral ischemia in mice via an integrative strain survey...
- Pharmacogenomic studies in VISP: results &implications for clinical trial designBradford B Worrall; Fiscal Year: 2011..to determine whether the daily intake of high dose folic acid, vitamins B6 and B12 reduced recurrent cerebral infarction and a combined vascular endpoint...
- Neuroglobin in Neuronal Hypoxi and Cerebral IschemiaDAVID ALAN GREENBERG; Fiscal Year: 2013..in vitro and ischemic cerebral injury in vivo, and that Ngb-overexpressing transgenic mice are resistant to cerebral infarction from occlusion of the middle cerebral artery...
- Culprit Plaque in Acute Cerebral Infarction: A Histological and MRI AssessmentThomas Hatsukami; Fiscal Year: 2013....
- NEUROPROTECTIVE EFFECT OF HEAT STRESS IN CORTICAL NEURONBARBARA SNIDER; Fiscal Year: 1999b>Cerebral infarction remains a significant cause of morbidity and mortality, with limited treatment options available...
- COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELSMichael Schreiber; Fiscal Year: 1992..Complications include intracranial hemorrhage, cerebral infarction, microcephaly, and seizures...
- Jun Kinase Signaling and Apoptosis in Ischemia StrokeChia Yi Kuan; Fiscal Year: 2006..for apoptosis induced by ischemia-hypoxia and whether the inhibition of JNK3 signaling protects against cerebral infarction. We will test the role of the constitutively active JNK1 isoform in global ischemia and the stress-induced ..
- STROKE PREVENTION TRIAL IN SICKLE CELL ANEMIADonald Brambilla; Fiscal Year: 2000..TCD) ultrasound which can detect arterial abnormalities which place these children at high risk for cerebral infarction. Prediction is based on the detection of high arterial blood flow rates which are associated with arterial ..
- STROKE PREVENTION TRIAL IN SICKLE CELL ANEMIA (STOP)Robert Adams; Fiscal Year: 2000..TCD) ultrasound which can detect arterial abnormalities which place these children at high risk for cerebral infarction. Prediction is based on the detection of high arterial blood flow rates which are associated with arterial ..
- Rheolytic Thrombectomy for Treatment of Ischemic StrokeCindy Setum; Fiscal Year: 2001..S. The majority of strokes are caused by cerebral infarction due to acute thrombus and arterial occlusion...
- COGNITIVE AND NEUROIMAGING STUDY OF SICKLE CELL ANEMIAElias Melhem; Fiscal Year: 2001..to neuropsychological impairment seen in children with Sickle Cell Disease (SCD) who have no evidence of cerebral infarction on conventional Magnetic Resonance Imaging (MRI)...
- EPIDEMIOLOGIC STUDY OF STROKE OUTCOME IN 3 ETHNIC GROUPSRalph Sacco; Fiscal Year: 1999..2 of Healthy People 2000. The aims of this revised competitive continuation are to compare outcomes after cerebral infarction among white (non-Hispanic), black (non-Hispanic) and Hispanic men and women residents of northern Manhattan,..
- Genetic Markers of Thrombosis in Embolic StrokeKaren Furie; Fiscal Year: 2006..Thus, it is imperative that markers of stroke risk be developed for this particular mechanism of cerebral infarction. In order to identify markers of embolic stroke risk, it is logical to focus on the hemostatic system, ..
- HUMAN ALBUMIN THERAPY-TREATMENT OF ACUTE ISCHEMIC STROKEMYRON GINSBERG; Fiscal Year: 2003..the safely tolerated maximum dose and administration of intravenous HSAlb in patients with acute ischemic cerebral infarction of 8 hours' duration or less; and to implement standardized procedures for monitoring cardiovascular ..
- AMYLOID ANGIOPATHY, EARLY PLAQUES & AGINGBlas Frangione; Fiscal Year: 2003..an important role in the pathogenesis of Alzheimer's disease since a combination of Alzheimer's disease and cerebral infarction is the second commonest type of dementia...
- PATHOPHYSIOLOGY OF THROMBOEMBOLIC STROKEW Dietrich; Fiscal Year: 2003..Recent experimental data indicate that a prior thromboembolic event is a risk factor for I widespread cerebral infarction and hemorrhage when combined with a dalayed ischemic insult...
- RANDOMIZED STUDY OF NICARDIPINE IN SAHNeal Kassell; Fiscal Year: 1992..Outcome measures will include neurological and disability status and cerebral infarction rate at three months following subarachnid hemorrhage and the occurrence of symptomatic vasospasm during ..
- HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTSSHARI WALDSTEIN; Fiscal Year: 2002DESCRIPTION: Hypertension is a major risk factor for cerebral infarction, intracranial hemorrhage, and vascular dementia, particularly among older adults...
- HLA AS A PREDICTOR FOR STROKE IN SICKLE CELL ANEMIALori Styles; Fiscal Year: 2001..cell anemia is the most common cause of stroke in childhood and 25% of children with SCA have evidence of cerebral infarction on MRI scanning...
- ANTIICAM-1 AND RTPA TREATMENT OF EMBOLIC STROKEMichael Chopp; Fiscal Year: 2002..The fundamental outcome measurements of the combination therapy will be volume of cerebral infarction and net hemorrhage...
- MECHANISMS OF ACTION OF IL 1 IN ISCHEMIC BRAINGuo Yuan Yang; Fiscal Year: 1999..The parameters of brain injury to be monitored include edema, cerebral infarction volume, cerebral blood flow, blood brain barrier permeability, and changes in pathology using methods of ..
- Focal Brain Ischemia in the TNF-alpha-Transgenic RatL Pettigrew; Fiscal Year: 2007..secreted by astroglia, macrophages, and other cells participating in the inflammatory reaction initiated by cerebral infarction. Levels of TNFalpha rise sequentially in the infarct core, the ischemic penumbra, and in unaffected tissue ..
- Chlamydia Infection as a Risk Factor for Cerebrovascula*Lori Styles; Fiscal Year: 2004..Our preliminary data indicates that SCA patients with MRI-documented cerebral infarction are 12 times more likely to have C. pneumoniae infection than SCA patients with normal MRI scans...
- PHYSIOLOGY OF NERVE, GLIAL AND MUSCLE CELL LINESDavid Schubert; Fiscal Year: 2005..In CNS pathologies such as localized cerebral infarction some neurons die rapidly by necrosis while others die more slowly by a programmed cell death pathway ..
- IN VIVO MRI QUANTIFICATION OF TISSUE PERMEABILITYHarold Kundel; Fiscal Year: 2001..nervous system including primary and secondary neoplasia, infection (HIV), vascular disorders (aneurysms), cerebral infarction and white matter disease (multiple sclerosis)...
- Etiology of cellular damage after experimental strokeJaroslaw Aronowski; Fiscal Year: 2005..proposed are largely based upon preliminary data linking cellular death to NF-kappaB activation after cerebral infarction and hemorrhage, and our recent finding of involvement of a novel enzyme in the NF-kappaB regulatory pathway,..
- Cerebral Arteriole Function during Hyperglycemic StrokeMarilyn Cipolla; Fiscal Year: 2009..reperfusion injury in the postischemic brain, including a significantly higher incidence and severity of cerebral infarction and edema formation...
- STROKE OUTCOME PREDICTION--CLINICAL/DIAGNOSTIC IMPACTMarcella Wozniak; Fiscal Year: 1999..to develop a multivariable predictor of 30 day and l year survival and stroke recurrence for patients with cerebral infarction. These predictors will be validated using data to be collected from the ongoing Maryland Stroke Data Bank (..
- COGNITIVE CHANGE IN CEREBROVASCULAR DISEASEJohn Morris; Fiscal Year: 2000..cerebral hemodynamics in ischemic stroke" (NS 28947; RL Grubb, PI) will provide patients at high risk for cerebral infarction (carotid occlusion patients) after completion of their neurological and cerebral hemodynamic assessments...
- AMP-KINASE CASCADE ACTIVATORS AND ATHEROGENESISJ Foulkes; Fiscal Year: 1992DESCRIPTION (Adapted from Applicant's Abstract):Myocardial and cerebral infarction, conditions which are primarily the result of atherosclerotic lesions within coronary and cerebral blood vessels, are the leading causes of death in ..
- Protection from Stroke by SF/HGF-like Small MoleculePrakash Narayan; Fiscal Year: 2004Atherosclerosis of the cerebral vasculature can produce occlusion and cerebral infarction. Although the tissue in the ischemia core dies within minutes, the surrounding tissue, termed the ischemic penumbra, sustains damage from ..
- Murine Cardiovascular MRIRobert Weiss; Fiscal Year: 2003..b>Cerebral infarction and microvascular function will be imaged in mice with diabetes and atherosclerosis...
- AFRICAN AMERICAN ANTIPLATELET STROKE PREVENTION STUDYPhilip Gorelick; Fiscal Year: 2004..Patients are enrolled no more than 90 days after incident cerebral infarction and are followed for 2 years. The investigators have already recruited 1400 of the needed 1800 subjects. Dr...
- PATHOLOGIC SEQUELAE OF INCOMPLETE CEREBRAL ISCHEMIARobert Dempsey; Fiscal Year: 1990..In this way a foundation for further studies of the evolution of cerebral infarction may be developed and the potential for slowing this process by inhibiting the contribution of harmful ..
- PLASMALOGENASE AND WHITE MATTER INJURYLLOYD HORROCKS; Fiscal Year: 1980..The gerbil model for cerebral infarction will be used...
- NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUSWilmer Sibbitt; Fiscal Year: 2000..Major NPSLE is characterized by seizures, psychosis, movement disorder, cerebral infarction, cognitive dysfunction, or death...
- EFFECT OF SPINAL CORD STIMULATION ON CEREBRAL BLOOD FLOWOren Sagher; Fiscal Year: 2004..We will also examine the feasibility of using SCS in the prevention of cerebral infarction. Specifically, we will test the following central hypotheses: I...
- Quality of Life Children With Sickle Cell DiseaseJulie Panepinto; Fiscal Year: 2009..overt stroke will be examined and compared to the health-related QOL of those with silent stroke and no cerebral infarction. The impact of family factors on the health-related QOL of the child will be determined...
- Exacerbation of AtherosclerosisGuangming Zhong; Fiscal Year: 2004..by the applicant): Atherosclerosis is the principal contributor to the pathogenesis of myocardial and cerebral infarction, and no effective treatment is yet available for atherosclerosis...
- Treatment of Hyperglycemia Ischemic Stroke(THIS)TrialAskiel Bruno; Fiscal Year: 2004..Additional measurements will include vital signs, serum electrolytes, hemoglobin A-1C, and a global test for multiple clinical outcomes at 3 months. ..
- CDP-choline: Mechanisms in Cerebral IschemiaRAO ADIBHATLA; Fiscal Year: 2006..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
- BODY REPRESENTATIONS--NEUROPSYCHOLOGY AND ANATOMIC BASISH Coslett; Fiscal Year: 2001..The potential clinical significance of this work is also clear. If, as hypothesized, the body schema is crucial to action, interventions targeting this representations may have important therapeutic implications. ..
- SPATIAL INFLUENCES ON LANGUAGE FUNCTIONH Coslett; Fiscal Year: 2002..abstract_text> ..
- Motor Imagery as a Measure of Pain SeverityH Coslett; Fiscal Year: 2007..Finally, as mental motor imagery tasks require minimal language capacity or abstract reasoning, we propose to investigate the use of these measures in subjects with cognitive impairment. ..
- The cognitive neuroscience of body knowledgeH Coslett; Fiscal Year: 2007..Understanding the cerebral basis of motor control and the body schema is likely to contribute substantially to the development of interventions that target these representations. [unreadable] [unreadable]..
- MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORSRaj Kalaria; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Neurobiologic Study of Psychological Distress & DementiaRobert S Wilson; Fiscal Year: 2010..g., tau positive tangles, cerebral infarction)...
- Circle of Willis variability and migraineBRETT LEE CUCCHIARA; Fiscal Year: 2010..of potential mechanisms underlying migraine aura and linking migraine with both clinical and subclinical cerebral infarction. Third, it could help to identify the subpopulation of patients at risk of progressive cerebral ischemia so ..
- Cognitive neuroscience of temporal processingH Branch Coslett; Fiscal Year: 2010..Finally, we propose to use transcranial magnetic stimulation to identify specific brain regions that are necessary for normal temporal processing. ..