brain infarction


Summary: The formation of an area of necrosis in the brain, including the cerebral hemispheres (see CEREBRAL INFARCTION), thalami, basal ganglia, brain stem (BRAIN STEM INFARCTIONS), or cerebellum secondary to an insufficiency of arterial or venous blood flow.

Top Publications

  1. ncbi Silent brain infarcts: a systematic review
    Sarah E Vermeer
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Lancet Neurol 6:611-9. 2007
  2. ncbi Silent brain infarcts: a review of MRI diagnostic criteria
    Yi cheng Zhu
    Department of Neurology, Peking Union Medical College Hospital, Beijing, China
    Stroke 42:1140-5. 2011
  3. ncbi Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study
    Ewoud J van Dijk
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 39:2712-9. 2008
  4. ncbi Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats
    Keyue Liu
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    FASEB J 21:3904-16. 2007
  5. pmc Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment
    Zhongwu Liu
    Neurology Research, E and R Building, Room 3056, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Stroke 39:2571-7. 2008
  6. ncbi Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction
    Jun Hata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Mol Genet 16:630-9. 2007
  7. ncbi Association between influenza vaccination and reduced risk of brain infarction
    Philippa Lavallée
    Department of Neurology and the Formation de Recherche en Neurologie Vasculaire Association Claude Bernard, Lariboisiere Hospital, Denis Diderot University, Paris, France corrected
    Stroke 33:513-8. 2002
  8. ncbi Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway
    Chao Liu
    Department of Pharmacology, Pharmaceutical College, Xianning University, Xianning, China
    J Neurochem 112:1500-12. 2010
  9. pmc Toll-like receptor signaling in endogenous neuroprotection and stroke
    B J Marsh
    Department of Molecular Microbiology and Immunology L220, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Neuroscience 158:1007-20. 2009
  10. ncbi Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy
    Vadim S Ten
    Department of Pediatrics, Columbia University, 3959 Broadway, BHS 12, Room 115, New York, NY 10032, USA
    Behav Brain Res 145:209-19. 2003

Detail Information

Publications268 found, 100 shown here

  1. ncbi Silent brain infarcts: a systematic review
    Sarah E Vermeer
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Lancet Neurol 6:611-9. 2007
    ..Future studies will have to show whether screening and treating high-risk patients can effectively reduce the risk of further infarcts, stroke, and dementia...
  2. ncbi Silent brain infarcts: a review of MRI diagnostic criteria
    Yi cheng Zhu
    Department of Neurology, Peking Union Medical College Hospital, Beijing, China
    Stroke 42:1140-5. 2011
    ..In this study, we aimed to evaluate the different MRI parameters and criteria used for their evaluation in the literature to better understand the variation across studies and related limitations...
  3. ncbi Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study
    Ewoud J van Dijk
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 39:2712-9. 2008
    ..We aimed to assess the relationship between risk factors, effect modifiers, and progression of these lesions. Furthermore, we studied the cognitive consequences of lesion progression...
  4. ncbi Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats
    Keyue Liu
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    FASEB J 21:3904-16. 2007
    ..treatment with neutralizing anti-HMGB1 monoclonal antibody (mAb; 200 microg, twice) remarkably ameliorated brain infarction induced by 2-h occlusion of the middle cerebral artery in rats, even when the mAb was administered after the ..
  5. pmc Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment
    Zhongwu Liu
    Neurology Research, E and R Building, Room 3056, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Stroke 39:2571-7. 2008
    ..We investigated contralesional corticospinal tract remodeling in the brain and spinal cord in rats after stroke and treatment of bone marrow stromal cells...
  6. ncbi Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction
    Jun Hata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Mol Genet 16:630-9. 2007
    b>Brain infarction is one of the common causes of death and also a major cause of severe disability...
  7. ncbi Association between influenza vaccination and reduced risk of brain infarction
    Philippa Lavallée
    Department of Neurology and the Formation de Recherche en Neurologie Vasculaire Association Claude Bernard, Lariboisiere Hospital, Denis Diderot University, Paris, France corrected
    Stroke 33:513-8. 2002
    Because infections subsequent to influenza may play a role in promoting the complications of atherosclerotic disease and may also induce hypercoagulation, we hypothesized that influenza vaccination may protect against brain infarction.
  8. ncbi Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway
    Chao Liu
    Department of Pharmacology, Pharmaceutical College, Xianning University, Xianning, China
    J Neurochem 112:1500-12. 2010
    ..Together, these findings provide evidence that Bai protects neurons against ischemia injury and this neuroprotective effect involves PI3K/Akt and PTEN pathway...
  9. pmc Toll-like receptor signaling in endogenous neuroprotection and stroke
    B J Marsh
    Department of Molecular Microbiology and Immunology L220, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Neuroscience 158:1007-20. 2009
    ..Thus genomic reprogramming of TLR signaling may be a unifying principle of tolerance to cerebral ischemia...
  10. ncbi Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy
    Vadim S Ten
    Department of Pediatrics, Columbia University, 3959 Broadway, BHS 12, Room 115, New York, NY 10032, USA
    Behav Brain Res 145:209-19. 2003
  11. ncbi Vasoactive intestinal peptide protects against ischemic brain damage induced by focal cerebral ischemia in rats
    Jie Yang
    Department of Human Anatomy, Histology and Embryology, School of Medicine, Xi an Jiaotong University, Xi an, Shaanxi 710061, China
    Brain Res 1398:94-101. 2011
    ..Our data suggest that treatment with VIP reduces brain damage in ischemic rats, and this effect may be associated with the attenuation of apoptosis and S100B expression...
  12. ncbi The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia
    Eiji Kitamura
    Department of Neurology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    Neurosci Res 68:154-7. 2010
    ..Administration of orexin-A at 0.3nmol significantly reduced the brain infarct area. The results suggested that orexin-A alters the pathological mechanisms involved in brain ischemia and has a neuroprotective effect...
  13. pmc Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling
    R Anne Stetler
    Department of Neurology and Center of Cerebrovascular Diseases Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 28:13038-55. 2008
    ..Based on these findings, we conclude that overexpression of Hsp27 confers long-lasting neuroprotection against ischemic brain injury via a previously unexplored association and inhibition of ASK1 kinase signaling...
  14. ncbi Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia
    Xinli Xiao
    Institute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Education Ministry, State Key Subject for Physiology, Xi an Jiaotong University College of Medicine, Xi an 710061, China
    Neurol Res 32:547-55. 2010
    ..To investigate the effects of tetramethylpyrazine (TMP) on neural cell proliferation and differentiation in brain of rat after focal cerebral ischemia...
  15. ncbi Metabolic penumbra of acute brain infarction: a correlation with infarct growth
    Eku Shimosegawa
    Department of Radiology and Nuclear Medicine, Research Institute of Brain and Blood Vessels, Akita, Japan
    Ann Neurol 57:495-504. 2005
    Volume expansion associated with brain infarction occurs in perfusion-diffusion mismatch of magnetic resonance imaging...
  16. ncbi Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts
    L M Cupini
    Clinica Neurologica, Ospedale S Eugenio, Universita di Roma Tor Vergata, Roma, Italy
    Stroke 33:689-94. 2002
    ..The present study examines the relationship between vascular risk factors, including carotid artery intima-media thickness (IMT), and lacunar versus nonlacunar infarcts...
  17. ncbi IkappaB-alpha expression following transient focal cerebral ischemia is modulated by nitric oxide
    Rosaria Greco
    University of Pavia, Pavia, Italy
    Brain Res 1372:145-51. 2011
    ..These findings suggest that NO of neuronal and inducible origin promotes NF-κB activation via IkB-alpha modulation and mediates ischemic-related damage in the brain following ischemia...
  18. ncbi Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2
    B Liebelt
    Department of Neurosurgery, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Neuroscience 166:1091-100. 2010
    ..Inhibiting HSP-70 or pERK 1/2 reversed this resultant increase or decrease. Our results indicate that exercise diminishes neuronal injury in stroke by up-regulating HSP-70 and ERK 1/2...
  19. ncbi The "good" limb makes the "bad" limb worse: experience-dependent interhemispheric disruption of functional outcome after cortical infarcts in rats
    Rachel P Allred
    Department of Psychology, C H Cappellini, Institute for Neuroscience, University of Texas at Austin, USA
    Behav Neurosci 124:124-32. 2010
    ..This suggests that this experience-dependent disruption of functional recovery is mediated through interhemispheric connections of the sensorimotor cortex...
  20. ncbi Measures of brain morphology and infarction in the framingham heart study: establishing what is normal
    Charles DeCarli
    Department of Neurology and Center for Neuroscience, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Neurobiol Aging 26:491-510. 2005
    ..Moreover, little attention has been paid to the possible impact of brain infarction on age-related differences in regional brain volumes...
  21. ncbi Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice
    Oliver B Dimitrijevic
    Department of Pathology, University of Michigan, Medical School, Ann Arbor, MI 48109 0532, USA
    Stroke 38:1345-53. 2007
    ..This study evaluated the role of the CCL2/CCR2 axis in regulating postischemic inflammation, BBB breakdown, and vasogenic edema formation...
  22. pmc Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning
    C Ren
    Department of Neurosurgery, Stanford University School of Medicine, MSLS Building, P306, 1201 Welch Road, Room P306, Stanford, CA 94305 5327, USA
    Neuroscience 151:1099-103. 2008
    ..In conclusion, remote preconditioning performed in one limb protected against ischemic damage after focal cerebral ischemia...
  23. ncbi Human cerebral infarct: a proposed histopathologic classification based on 137 cases
    Hernando Mena
    Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Acta Neuropathol 108:524-30. 2004
    ..Neuronophagia is not a feature of cerebral infarcts...
  24. ncbi Relations of serum high-sensitivity C-reactive protein and interleukin-6 levels with silent brain infarction
    Taku Hoshi
    Division of Stroke Medicine, Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, Osaka, Japan
    Stroke 36:768-72. 2005
    Small silent brain infarction (SBI) is often found on magnetic resonance (MR) images of apparently healthy individuals at cardiovascular risk...
  25. ncbi Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation
    Yu Chang Hou
    Department of Chinese Medicine, Taoyuan General Hospital, Department of Health, Department of Nursing, Yuanpei University, Hsinchu, Taiwan
    Phytomedicine 17:963-73. 2010
    ..Pretreatment with silymarin, but not silibinin, dose-dependently (1-10μg/kg, i.v.) reduced CI/R-induced brain infarction by 16-40% and improved neurological deficits in rats with a stroke...
  26. ncbi Early hemorrhagic transformation of brain infarction: rate, predictive factors, and influence on clinical outcome: results of a prospective multicenter study
    Maurizio Paciaroni
    Stroke Unit, Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant Andrea delle Fratte, Perugia, 06126 Italy
    Stroke 39:2249-56. 2008
    ..The aims of this study were to assess: (1) the rate of early HT in patients admitted for ischemic stroke, (2) the correlation between early HT and functional outcome at 3 months, and (3) the risk factors for early HT...
  27. ncbi Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study
    Sarah E Vermeer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 34:392-6. 2003
    ..The incidence of silent brain infarcts is unknown. We investigated the incidence and cardiovascular risk factors for silent brain infarcts...
  28. ncbi Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury
    Jing Xiao
    Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Stem Cells Dev 14:722-33. 2005
  29. ncbi Cerebral microbleeds and cognitive functioning in the PROSPER study
    A C G M van Es
    Department of Radiology, Section of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands
    Neurology 77:1446-52. 2011
    ..Little is known about the functional consequences of MBs in the aging population. In this study we investigated whether the presence and location of MBs are associated with cognition in the PROSPER study...
  30. ncbi Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction
    Lang Wang
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, PR China
    J Neurochem 126:400-14. 2013
    ..The Akt /FoxO1 signaling pathway probably plays an important role in the biological function of TRAF5 in this model. ..
  31. ncbi Imaging evolution of acute lacunar infarction: leukoariosis or lacune?
    Sebastian Koch
    Department of Neurology, Miller School of Medicine, University of Miami, 1150 NW 14th Street, Suite 304, Miami, FL 33141, USA
    Neurology 77:1091-5. 2011
    ..Our objective was to examine eventual infarct size, the incidence of cavity formation, and factors associated with cavitation in patients presenting with acute lacunar infarction...
  32. ncbi Prevalence, incidence, and risk factors of lacunar infarcts in a community sample
    Xiaohua Chen
    Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
    Neurology 73:266-72. 2009
    ..The prevalence and risk factor profile of lacunar infarction has been variously reported, but the incidence data are scarce for large community-based data...
  33. ncbi A comparison of different models of stroke on behaviour and brain morphology
    C L R Gonzalez
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Eur J Neurosci 18:1950-62. 2003
    ..These results suggest that: (i) different lesions to the motor cortex produce subtle differences in behaviour, and (ii) the method used to induce the lesion produces striking differences in cortical and subcortical plasticity...
  34. ncbi Pre-ischemic treadmill training induces tolerance to brain ischemia: involvement of glutamate and ERK1/2
    Feng Zhang
    Department of Rehabilitation Medicine, Hua Shan Hospital, Fudan University, Shanghai, China
    Molecules 15:5246-57. 2010
    ..This study suggests that pre-ischemic treadmill training might induce neuroprotection by inhibiting the phospho-ERK1/2 over-activation and reducing excessive glutamate release...
  35. pmc Prevalence and determinants of subclinical brain infarction: the Northern Manhattan Study
    S Prabhakaran
    Rush University Medical Center, Chicago, IL, USA
    Neurology 70:425-30. 2008
    ..We examined the prevalence and determinants of SBI in a multiethnic community cohort...
  36. ncbi Silent brain infarcts, leukoaraiosis, and long-term prognosis in young ischemic stroke patients
    J Putaala
    Department of Neurology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN 00290, Helsinki, Finland
    Neurology 76:1742-9. 2011
    ..To investigate prognostic relevance of silent brain infarcts (SBIs) and leukoaraiosis (LA) in young patients with ischemic stroke...
  37. pmc Immunological profile of silent brain infarction and lacunar stroke
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
    PLoS ONE 8:e68428. 2013
    ..The differences in plasma profile of inflammatory molecules may underlie different pathological mechanisms in SBI and LI patients. ..
  38. ncbi An analysis of four different methods of producing focal cerebral ischemia with endothelin-1 in the rat
    Victoria Windle
    Basic Medical Sciences, Faculty of Medicine, Memorial University, St John s, NL, Canada
    Exp Neurol 201:324-34. 2006
    ..The combined cortical and striatal injection model offers a number of advantages for studies of recovery of function...
  39. ncbi Post-treatment with selective β1 adrenoceptor antagonists provides neuroprotection against transient focal ischemia in rats
    Toru Goyagi
    Department of Anesthesia and Intensive Care Medicine, Akita University Graduate School of Medicine, Akita, Japan
    Brain Res 1343:213-7. 2010
    ..05). The current study indicates that administration of selective beta1-adrenoceptor antagonists after the onset of ischemia also improved neurological and histological outcomes following transient focal cerebral ischemia in rats...
  40. ncbi Neuroprotective effect of flurbiprofen in focal cerebral ischemia: the possible role of ASIC1a
    Vikas Mishra
    Division of Pharmacology, Central Drug Research Institute CSIR, P O Box 173, Lucknow 226001, U P, India
    Neuropharmacology 59:582-8. 2010
    ..These studies thus provide neuroprotective profile of flurbiprofen in focal cerebral ischemia with its selective effect on ASIC1a...
  41. ncbi Counting cavitating lacunes underestimates the burden of lacunar infarction
    Gillian M Potter
    Division of Clinical Neurosciences and SINAPSE Collaboration, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Stroke 41:267-72. 2010
    ..The proportion of symptomatic lacunar infarcts that progress to lacunes is unknown. Noncavitating lacunar infarcts may continue to resemble white matter lesions...
  42. pmc Neuronal Ca2+-activated K+ channels limit brain infarction and promote survival
    Yiliu Liao
    Pharmacology and Toxicology, Institute of Pharmacy, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e15601. 2010
    ..These results indicate that neuronal BK channels are important for protection against ischemic brain damage...
  43. ncbi Neuroprotective effects of progesterone following stroke in aged rats
    Jianping Wang
    Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People s Republic of China
    Behav Brain Res 209:119-22. 2010
    ..These findings point to the response of aged adult rats to PROG in cerebral ischemia, and suggest that such response need to be considered in the development of neuroprotective agents for stroke...
  44. ncbi Protective effect of docosahexaenoic acid against brain injury in ischemic rats
    Hung Chuan Pan
    Chung Hwa University of Medical Technology, Tainan, Taiwan
    J Nutr Biochem 20:715-25. 2009
    ..Reduction of brain infarction was found in all three DHA-pretreated groups...
  45. pmc Niaspan treatment induces neuroprotection after stroke
    Amjad Shehadah
    Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA
    Neurobiol Dis 40:277-83. 2010
    ..In this study, we tested whether Niaspan administered acutely after stroke is neuroprotective...
  46. ncbi Reduction of the infarct size by simultaneous administration of L-histidine and diphenhydramine in ischaemic rat brains
    Naoto Adachi
    Mabuchi Clinic, Kyoto shi, Kyoto, Japan
    Resuscitation 82:219-21. 2011
  47. ncbi Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
    Mohammad Allahtavakoli
    Department of Physiology, Rafsanjan University of Medical Sciences, Iran
    Brain Res Bull 85:219-24. 2011
    ..The findings of the present study suggest that part of the neuroprotective effects of sigma-1 receptor agonists may be mediated through a dual effect on cytokine release following stroke...
  48. ncbi Serum highly selective C-reactive protein concentration is associated with the volume of ischemic tissue in acute ischemic stroke
    Chun Song Youn
    Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Am J Emerg Med 30:124-8. 2012
    ..The aim of this study was to clarify the relationship between inflammatory markers and stroke severity by means of volumetric measurement of infarct size...
  49. ncbi A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats
    Satoshi Iihoshi
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, South 1st, West 16th, Chuo, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1007:1-9. 2004
    ..These findings suggest that early intervention with intravenous administration of autologous mononuclear cells from bone marrow can reduce lesion size in the MCAO model in the rat, and improve functional outcome...
  50. ncbi Tropisetron ameliorates ischemic brain injury in an embolic model of stroke
    Reza Rahimian
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Brain Res 1392:101-9. 2011
    ..15 mg/kg), tacrolimus (1mg/kg), or tacrolimus (1mg/kg) plus tropisetron (3mg/kg) significantly curtailed brain infarction, improved behavioral scores, diminished elevated tissue MPO activity, and reduced TNF-α levels compared to ..
  51. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
    ..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain...
  52. ncbi Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Kita, Kagawa, Japan
    Neurosci Lett 487:103-6. 2011
    ..The number of AP-sites and 8-OHdG levels were also reduced by D-allose. Thus, the present study suggests that D-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia...
  53. ncbi Effects of acute post-treatment with dipyridamole in a rat model of focal cerebral ischemia
    Lidia Garcia-Bonilla
    Neurovascular Research Laboratory, Institut de Recerca Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Brain Res 1373:211-20. 2011
    ..In selected animals, intravenous administration of high dose DP induced an adverse hypotensive effect leading to rapid death. Thus, alternative ways of acute administration must be examined in order to avoid this unfavorable effect...
  54. ncbi The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats
    Eiji Abe
    Department of Neurosurgery, School of Medicine, Oita University, 1 1, Idaigaoka, Hasama machi, Oita, 879 5593, Japan
    Brain Res 1330:151-7. 2010
    ..These results suggest that a single oral dose of GGA induces p-Akt and that GGA plays an important role in neuroprotection against cerebral ischemia through the mitoK(ATP) channel opening...
  55. ncbi Physiological correlates of intellectual function in children with sickle cell disease: hypoxaemia, hyperaemia and brain infarction
    Alexandra M Hogan
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, UK
    Dev Sci 9:379-87. 2006
    ..This supports the hypothesis that lowered intellectual function is partly explained by chronic hypoxia, and has wider implications for our understanding of SCD pathophysiology...
  56. ncbi An angiotensin II type 1 receptor blocker can preserve endothelial function and attenuate brain ischemic damage in spontaneously hypertensive rats
    Naoki Oyama
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 88:2889-98. 2010
    ..These findings indicate that chronic prehypertensive treatment with olmesartan could attenuate brain ischemic injury through the maintenance of endothelial function in the cerebral cortex in SHR...
  57. ncbi Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction
    Yusuke Takatsuru
    Japan Science and Technology Agency, Kawaguchi, Japan
    J Neurosci 29:10081-6. 2009
    ..This finding could contribute to establish the effective clinical treatments targeted on the intact hemisphere for the recovery of impaired functions and to achieve better quality of life of patients...
  58. ncbi Endothelial activation in lacunar stroke subtypes
    Iris L H Knottnerus
    Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Stroke 41:1617-22. 2010
    ..Here, we determined levels of circulating blood markers of endothelial function in LS patients...
  59. ncbi Enriched environment enhances transplanted subventricular zone stem cell migration and functional recovery after stroke
    A U Hicks
    Basic Medical Sciences, Faculty of Medicine, Memorial University, St John s, NL, Canada A1B3V6
    Neuroscience 146:31-40. 2007
    ..These results suggest that the ability of transplanted stem cells in promoting recovery can be augmented by environmental factors such as rehabilitation...
  60. ncbi Temporal profile of serum anti-inflammatory and pro-inflammatory interleukins in acute ischemic stroke patients
    F Perini
    Headache and Cerebrovascular Disease Center, Stroke Unit, Neurology Division, S. Bortolo Hospital, Vicenza, Italy
    Neurol Sci 22:289-96. 2001
    ..The physiological balance between these two molecules is altered in acute stroke patients...
  61. ncbi The increase of neuron-specific enolase in cerebrospinal fluid and plasma as a marker of neuronal damage in patients with acute brain infarction
    V Selakovic
    Institute for Medical Research, Unviersity of Belgrade, Serbia
    J Clin Neurosci 12:542-7. 2005
    ..enolase (NSE) concentration in cerebrospinal fluid (CSF) and plasma in patients with the acute brain infarction (BI) and analyze the correlation between the measured NSE concentration and infarct volume and the degree of ..
  62. ncbi Spatio-temporal distribution of inflammatory reaction and expression of TLR2/4 signaling pathway in rat brain following permanent focal cerebral ischemia
    Xian Kun Tu
    Department of Neurosurgery, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian, China
    Neurochem Res 35:1147-55. 2010
    ..Our studies suggested that TLR2/4 signaling pathway likely aggravated ischemic brain injury through mediating the inflammatory reaction. TLR2/4 signaling pathway may be a promising therapeutic target for cerebral ischemia injury...
  63. pmc Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume
    Heidi Ormstad
    Vestre Viken Hospital Trust, Bærum sykehus, Postbox 83, 1309 Rud, Norway
    J Neurol 258:677-85. 2011
    ..Elevated GRO-α in AIS patients with radiologically confirmed infarctions suggests that GRO-α is specific for stroke of known etiology. Our results indicate that CRP plays an important role in the progression of cerebral tissue injury...
  64. ncbi Cystatin C and subclinical brain infarction
    Stephen L Seliger
    Division of Nephrology, University of Maryland, Baltimore, MD 21201, USA
    J Am Soc Nephrol 16:3721-7. 2005
    ..Compared with creatinine, CysC, a novel marker of renal function, has a stronger and more direct association with SBI in the elderly...
  65. ncbi Variability of the systemic acute phase response after ischemic stroke
    Craig J Smith
    Division of Medicine and Neurosciences, University of Manchester, Clinical Sciences Building, Hope Hospital, Salford, UK
    J Neurol Sci 251:77-81. 2006 analysis of individual APR profiles in 31 patients with ischemic stroke in relation to volume of brain infarction. Patients with ischemic stroke had serial blood samples taken within 12 h, and up to 12 months of symptom ..
  66. ncbi Protective effect of green tea extract on ischemia/reperfusion-induced brain injury in Mongolian gerbils
    J T Hong
    National Institute of Toxicological Research, Korea Food and Drug Administration, 5, Nokbun dong, Eunpyung Gu, 122 704, Seoul, South Korea
    Brain Res 888:11-18. 2001
    ..This study therefore suggests that green tea may be a useful agent for the prevention of cerebral ischemia damage...
  67. ncbi Association between PRKCH gene polymorphisms and subcortical silent brain infarction
    M Serizawa
    Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Atherosclerosis 199:340-5. 2008
    ..0026 for AA+AG vs. GG, adjusted odds ratio=1.27; 95% CI, 1.09-1.48). As the two SNPs appear to be common only in Asian people, further replication study is warranted in the other Asian populations as well as the Japanese...
  68. pmc Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats
    Steve Leu
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Transl Med 8:63. 2010
    The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status in a rat model of acute ischemic stroke (IS) was investigated.
  69. ncbi Upregulation of albumin expression in focal ischemic rat brain
    Kanaiyalal D Prajapati
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
    Brain Res 1327:118-24. 2010
    ..This study paves the way for further investigation of signaling mechanisms leading to albumin overexpression, so that it can be exploited as a therapeutic intervention...
  70. pmc Bone marrow-derived cells are the major source of MMP-9 contributing to blood-brain barrier dysfunction and infarct formation after ischemic stroke in mice
    Guangming Wang
    Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, USA
    Brain Res 1294:183-92. 2009
    ..These findings suggest that MMP-9 released from bone marrow-derived cells influences the progression of BBB disruption in the ischemic brain...
  71. ncbi PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway
    G D Shi
    Department of Orthopaedics Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, PR China
    Biochem Biophys Res Commun 404:941-5. 2011
    ..These data suggest that PTEN deletion prevents neuronal cell death resulting from ischemic brain injury and that its neuroprotective effects are mediated by increasing the injury-induced mTOR phosphorylation...
  72. ncbi Effects of green tea polyphenols on caveolin-1 of microvessel fragments in rats with cerebral ischemia
    Sai Zhang
    Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang China
    Neurol Res 32:963-70. 2010
  73. ncbi Association between diabetes and stroke subtype on survival and functional outcome 3 months after stroke: data from the European BIOMED Stroke Project
    Salah Eddine Megherbi
    Stroke Registry of Dijon, Faculty of Medicine of Dijon, Burgundy University, Dijon, France
    Stroke 34:688-94. 2003
    ..We sought to evaluate stroke features, prognosis, and functional outcome in patients with diabetes compared with patients without diabetes...
  74. ncbi The role of corticospinal tract damage in chronic motor recovery and neurorehabilitation: a pilot study
    Annette Sterr
    Department of Psychology, University of Surrey, Guildford, United Kingdom
    Neurorehabil Neural Repair 24:413-9. 2010
  75. ncbi Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex
    S Thomas Carmichael
    Department of Neurology, Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Exp Neurol 193:291-311. 2005
    ..This region may be a growth-promoting zone after stroke...
  76. ncbi Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injury
    So Young Hwang
    Department of Physiology and Biophysics, College of Medicine, Inha University, Incheon, South Korea
    Glia 58:1881-92. 2010
    ..Finally, our results suggest that GlcN or its derivatives may serve as novel neuroprotective or anti-inflammatory agents...
  77. pmc Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome
    Craig J Smith
    University of Manchester, Manchester M13 9PT, UK
    BMC Neurol 4:2. 2004
    ..We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome...
  78. pmc Ginsenoside rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window
    Ruidong Ye
    Department of Neurology, Xijing Hospital, Xi an, China
    Neurotherapeutics 8:515-25. 2011
    ..These findings suggest Rd is a promising neuroprotectant and provide support for future clinical studies to confirm whether Rd is beneficial in ischemic stroke...
  79. ncbi Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats
    Xinjie Bao
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China
    Brain Res 1367:103-13. 2011
    ..Overall, these data suggest an essential role for hBMSCs in promoting endogenous neurogenesis, protecting newly formed cells, and improving functional recovery after ischemia in rats...
  80. ncbi Domains and determinants of quality of life after stroke caused by brain infarction
    M L Kauhanen
    Department of Neurology, University of Oulu, Finland
    Arch Phys Med Rehabil 81:1541-6. 2000
  81. ncbi Cerebral venous sinus thrombosis in children: a multicenter cohort from the United States
    Mohammad Wasay
    Aga Khan University, Karachi, Pakistan
    J Child Neurol 23:26-31. 2008
    ..In conclusion, cerebral venous thrombosis predominantly affects children younger than age 6 months. Mortality is high (25%) in neonatal cerebral venous thrombosis. Only 18 (25%) patients were treated with anticoagulation or thrombolysis...
  82. ncbi Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats
    Thomas J Toung
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 24:1160-6. 2004
    ..These data have potential clinical implications relative to stroke for postmenopausal women taking combined hormone replacement therapy...
  83. pmc Are lacunar strokes really different? A systematic review of differences in risk factor profiles between lacunar and nonlacunar infarcts
    Caroline Jackson
    Division of Clinical Neurosciences, University of Edinburgh, United Kingdom
    Stroke 36:891-901. 2005
    ..Differences in risk factors between lacunar and nonlacunar infarcts might support a distinct arterial pathological process underlying lacunar infarction...
  84. ncbi Reduced severity of strokes in patients with silent brain infarctions
    Y S Kim
    Department of Neurology, Hanyang University College of Medicine, Seoul, Korea
    Eur J Neurol 18:962-71. 2011
    ..This study investigated the independent effect of silent radiologic abnormalities on initial stroke severity and short-term outcome...
  85. ncbi Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction
    Kenji Isahaya
    Department of Neurology, St Marianna University School of Medicine
    J Stroke Cerebrovasc Dis 21:102-7. 2012
    ..Further studies with a larger sample size are needed to explore the relationship between circulating MMP-9 level and the protective effect of edaravone...
  86. ncbi Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk
    Young Joo Jeon
    Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
    Arterioscler Thromb Vasc Biol 33:420-30. 2013
    ..However, the effect of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported.
  87. ncbi Therapeutic effects of a reducible poly (oligo-D-arginine) carrier with the heme oxygenase-1 gene in the treatment of hypoxic-ischemic brain injury
    Hyesun Hyun
    Department of Bioengineering, College of Engineering, Hanyang University, Seoul 133 791, Republic of Korea
    Biomaterials 31:9128-34. 2010
    ..These results suggest that rPOA is a potential non-viral vector for HO-1 gene therapy to protect brain cells from I/R-related neuronal injury including stroke...
  88. ncbi Neutralizing the neurotoxic effects of exogenous and endogenous tPA
    William M Armstead
    Department of Anesthesiology, University of Pennsylvania, 3620 Hamilton Walk, JM3, Philadelphia, Pennsylvania 19104, USA
    Nat Neurosci 9:1150-5. 2006
    ..These experiments suggest mechanisms to reduce the neurotoxic effects of tPA without compromising its fibrinolytic activity, through the use of selective antagonists and new tPA formulations...
  89. ncbi Acrolein, IL-6 and CRP as markers of silent brain infarction
    Madoka Yoshida
    Chiba University, Inohana, Chuo Ku, Japan
    Atherosclerosis 203:557-62. 2009
    ..We then investigated whether silent brain infarction (SBI) can be detected by measuring acrolein, PAO, or other biomarkers...
  90. ncbi Qureshi grading scheme predicts subsequent volume of brain infarction following intra-arterial thrombolysis in patients with acute anterior circulation ischemic stroke
    Yousef M Mohammad
    Department of Neurology, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Neuroimaging 18:262-7. 2008
    ..Qureshi recently proposed a scheme that categorizes patients with ischemic stroke based on findings observed on initial angiography...
  91. ncbi Effects of duplicate administration of human neural stem cell after focal cerebral ischemia in the rat
    Miyeoun Song
    Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea
    Int J Neurosci 121:457-61. 2011
    ..Our study suggests that duplicate i.v. administration of hNSCs after stroke offers no advantages over single administration, 1 day following an ischemic event...
  92. ncbi Brain infarction after percutaneous implantation of port-catheter system via the left subclavian artery
    T Hirota
    Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo, Japan
    Br J Radiol 75:799-804. 2002
    The aim of this study was to evaluate the incidence of brain infarction after percutaneous implantation of a port-catheter system via the left subclavian artery for hepatic arterial infusion chemotherapy...
  93. ncbi Addition of brain infarction to the ABCD2 Score (ABCD2I): a collaborative analysis of unpublished data on 4574 patients
    Matthew F Giles
    Stroke Prevention Research Unit M F G, P M R, National Institute for Health Research Biomedical Research Centre, Oxford, UK
    Stroke 41:1907-13. 2010
    ..We therefore performed an international, multicenter collaborative study of the prognostic performance of the ABCD(2) score and brain infarction on imaging to determine the optimal weighting of infarction in the score (ABCD(2)I).
  94. ncbi Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats
    Baiba Svalbe
    Latvian Institute of Organic Synthesis, Riga, Latvia University of Latvia, Riga, Latvia
    Behav Brain Res 222:26-32. 2011
    ..Infarct size did not differ among the experimental groups on post-stroke day 14. The present study suggests that mildronate treatment improves the functional outcome in MCAO rats without influencing infarct size...
  95. ncbi Soluble thrombomodulin and brain infarction: case-control and prospective study
    Jean Marc Olivot
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, Paris, France
    Stroke 35:1946-51. 2004
    ..One study found no relationship between brain infarction (BI) and sTM levels...
  96. ncbi Virchow-Robin spaces relate to cerebral small vessel disease severity
    R P W Rouhl
    Dept of Neurology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Neurol 255:692-6. 2008
    ..In the present study we assessed the relation between VRs and silent ischemic lesions in a cohort of patients with cerebral small vessel disease...
  97. ncbi [An elder case of neurosarcoidosis associated with brain infarction]
    Hideaki Nakagaki
    Department of Neurology, Aso Iizuka Hospital
    Rinsho Shinkeigaku 44:81-5. 2004
    ..The psychotic symptoms and consciousness disturbance rapidly ameliorated after the treatment with oral prednisolone, 40 mg/day. Neurosarcoidosis should be considered even in an elder case of sarcoidosis complicated with a stroke...
  98. ncbi [Specificity effect of acupuncture at "Shuigou" (GV 26) on brain infarction area in MCAO rats and the influence of acupuncture parameter]
    Yuan Yuan Wei
    Acupuncture and Massage College, Tianjin University of TCM, Tianjin 300193, China
    Zhongguo Zhen Jiu 30:221-5. 2010
    ..To investigate the specificity of the acupoints and related factors on acupuncture effects...
  99. ncbi 6-Mercaptopurine exerts an immunomodulatory and neuroprotective effect on permanent focal cerebral occlusion in rats
    Chih Zen Chang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Acta Neurochir (Wien) 152:1383-90; discussion 1390. 2010
    ..The present study was aimed to examine the effect of 6-mp on cytokine levels in experimental stroke...
  100. ncbi Identification of embolic stroke patterns by diffusion-weighted MRI in clinically defined lacunar stroke syndromes
    Tiemo Wessels
    Department of Neurology, Justus Liebig University of Giessen, Germany
    Stroke 36:757-61. 2005
    ..To verify the reliability of the clinical diagnosis "lacunar syndrome," the value was investigated with diffusion-weighted MRI (DWI)...
  101. ncbi Accuracy of perfusion-CT in predicting malignant middle cerebral artery brain infarction
    R Dittrich
    Dept of Neurology, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48129 Muenster, Germany
    J Neurol 255:896-902. 2008
    We performed a prospective study on patients with middle cerebral artery(MCA) ischemic stroke to evaluate the accuracy of perfusion-CT imaging(PCT) to predict the development of malignant brain infarction (MBI).

Research Grants67

  1. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..depleting ATP stores and provoking energetic failure, loss of cellular homeostasis, neuronal necrosis, and brain infarction. The relevance of PARP activation to TBI is not merely in the initiation of brain injury, but also figures ..
    Gregory J Zipfel; Fiscal Year: 2013
    ..CAA is a powerful risk factor for brain infarction and dementia, and is associated with severe CV dysfunction...
  3. Dietary targeting of dihydrolipoamide dehydrogenase for stroke tolerance
    Liang Jun Yan; Fiscal Year: 2013 supplemented with 5-methoxyindole-2- carboxylic acid (MICA), a specific and competitive DLDH inhibitor, brain infarction volume decreased by c...
  4. 3D Structure and Function of CRAC Channels
    STEPHEN BARSTOW LONG; Fiscal Year: 2013 also required for platelet activation and breast tumor cell migration, suggesting that channel inhibitors may have therapeutic applications for preventing arterial thrombosis, ischemic brain infarction, and breast cancer metastasis.
    Ying Xia; Fiscal Year: 2013
    ..The most striking finding is that EA remarkably reduces brain infarction due to the occlusion of middle cerebral artery, which is dependent on the EA-triggered cellular/molecular ..
  6. Mechanisms of G-CSF-Induced Neuroprotection
    Jiping Tang; Fiscal Year: 2012
    ..Brain damage will be measured by brain tissue loss, edema formation, blood-brain barrier disruption, brain infarction, and cellular morphological changes...
  7. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2012
    ..role and mechanisms of antiphospholipid antibodies (aPL) in the development of pathologically-proven ischemic brain infarction. Our primary objective is to determine whether aPL are an independent risk factor/predictor for ischemic ..
  8. Oxidative Stress and Pathological Glutamate Release in Stroke
    Alexander A Mongin; Fiscal Year: 2013
    ..test the neuroprotective potential of the pharmacological treatments validated in AIMS 1 and 2, by measuring brain infarction volumes in the control ischemia group and after treatment with neuroprotectants...
  9. Recombinant annexin A2 plus tPA for combination stroke therapy
    Xiaoying Wang; Fiscal Year: 2013
    ..The development of brain infarction, edema and hemorrhagic transformation will be measured and correlated with temporal profiles of MMP-9 ..
  10. Neuro-vascular Disease as a Cause of Impaired Mobility
    Joshua Zebadiah Willey; Fiscal Year: 2013
    ..frontal lobe versus peri-ventricular for example) measures of white matter hyperintensities and silent brain infarction is acting as mediators...
    Roberto Heros; Fiscal Year: 1991
    ..Sequential changes on rCBF and O2a and volume of brain infarction in the four groups will be compared. The last project will compare the effects of hemodilution at 1 hour...
    Joan Moroney; Fiscal Year: 1999
  13. PARP inhibitory therapy of acute ischemic stroke
    Andrew Salzman; Fiscal Year: 2004
    ..We will assess the effect of INO-1001 on 1) brain infarction, as quantitated by MRI, and 2) neurologic dysfunction, as assessed at baseline, 4 days, I week, 2 weeks, and ..
    Leora Cherney; Fiscal Year: 1993
    ..Ten subjects with primarily anterior and ten with primarily posterior atherothrombotic brain infarction in the right hemisphere, and ten matched control subjects will participate...
  15. Photothrombotic Brain Infarction and Epileptogenesis
    Kevin Kelly; Fiscal Year: 2005
    ..2001a). Recent studies in our laboratory have indicated that the technique of cortical photothrombosis and brain infarction can result in poststroke epilepsy in young adult rats characterized electrically by seizures originating in ..
  16. Middle Cerebral and Common Artery Occlusion and Poststroke Epilepsy
    Kevin Kelly; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  17. Frontotemporal degeneration: a basis for clinical trials
    David Knopman; Fiscal Year: 2006
    ..abstract_text> ..
  18. Amyloid Imaging in Frontotemporal Dementia and Alzheimer's Disease
    William Jagust; Fiscal Year: 2009
    ..PIB could become a diagnostic tool that is useful in diagnosing AD and FTLD during life. This will be especially important as new treatments for both disorders are developed. ..
  19. Human Perinatal Brain Injury and Outcome: MRI Assessemnt
    PATRICIA GRANT; Fiscal Year: 2006
    ..The project is expected to only help the candidate establish an independent research career and to contribute to an understanding of perinatal brain injury. ..
  20. Heavy Drinking & Coronary Disease: Acute/Chronic Effects
    Kenneth Mukamal; Fiscal Year: 2006
    ..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
  21. B12 Absorption, Kinetics and Transcobalamin Genotype
    Joshua Miller; Fiscal Year: 2004
    ..This novel method would ultimately replace the Schilling test, the current gold standard, but flawed and cumbersome method for clinical assessment of B 12 absorptive capacity. ..
  22. Study of Carotid Occlusion and Neurocognition (RECON)
    RANDOLPH MARSHALL; Fiscal Year: 2009
  23. Alzheimer's ABeta, Apolipoproteins & Blood-Brain Barrier
    Berislav Zlokovic; Fiscal Year: 2004
  24. Perception and Recovery of Motion for Visually Guided Behavior in Humans
    Lucia Maria Vaina; Fiscal Year: 2010
    ..abstract_text> ..
    Roger Simon; Fiscal Year: 2009
    ..Finally, using continuous video-EEC monitoring, we will investigate how prevention of neuronal damage following seizures effects the development of an epileptic phenotype. ..
    SHARI WALDSTEIN; Fiscal Year: 2008
    ..abstract_text> ..
  27. Acid-sensing ion channels and ischemic brain injury
    Roger Simon; Fiscal Year: 2009
    ..These experiments will describe new, glutamate independent, mechanisms of ischemic brain injury and the central role of ischemic-acidosis. ASIC blockade will offer new and potent potential therapy for stroke. ..
    Julie Chao; Fiscal Year: 2008
    ..abstract_text> ..
  29. Role of COX-2 Gene Expression in Ischemic Brain Damage
    Costantino Iadecola; Fiscal Year: 2010
    ..abstract_text> ..
  30. Cell excitation in ischemic brain injury.
    Roger Pancoast Simon; Fiscal Year: 2010
    ..As such, understanding the endogenous mechanisms that regulate rapid ischemic tolerance may lead to the identification of novel therapeutic targets for the treatment of stroke. ..
  31. Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis
    Myriam Fornage; Fiscal Year: 2010
  32. Simvastatin treatment of experimental intracerebral hemorrhage
    DONALD M SEYFRIED; Fiscal Year: 2010
  33. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  34. Effects of Chemotherapy on Brain Function
    William J Jagust; Fiscal Year: 2010
    ..They are also relevant to the overall mission of the NIH because of the negative impact that cognitive dysfunction has on quality of life. ..
  35. Neurovascular Coupling in Hypertension
    Costantino Iadecola; Fiscal Year: 2004
    ..The results of these studies will enhance our understanding of the effects of hypertension on the brain and may provide new insights into treatment strategies aimed at counteracting these detrimental actions. ..
  36. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
    Costantino Iadecola; Fiscal Year: 2008
    ..The proposed studies are relevant to human diseases, such as hypertension-induced cognitive dysfunction, cardiovascular complications of sleep apnea, and cardiovascular diseases in post-menopausal women. ..
  38. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  39. Screening Technology and Outcomes Project in Stroke
    Karen Furie; Fiscal Year: 2005
    ..abstract_text> ..
  40. Vascular Protection in Acute Ischemic Stroke
    Susan Fagan; Fiscal Year: 2005
    ..Collectively, the successful completion of the research summarized in this proposal can be expected to contribute to the development of methods to make reperfusion safer, and therefore more accessible, to human stroke patients. ..
  41. 2004 Barriers of CNS
    MARTHA O DONNELL; Fiscal Year: 2004
    ..Two open workshops/debates to occur during the meeting are also planned. The maximum permitted attendance at this meeting is 150 scientists. ..
    LUCIA VAINA; Fiscal Year: 2005
  43. Caspases mediate seizure-induced brain injury
    Roger Simon; Fiscal Year: 2004
    ..Elucidation of the molecular control of seizure-induced cell death will further our understanding of brain injury processes and take a significant step toward therapeutic approaches to reduce brain injury in epilepsy. ..
    John Kern; Fiscal Year: 2004
    ..Basic research is needed, however, before applying this technique clinically. ..
  45. Evaluation of Antioxidant Suppl in Focal CNS Ischemia
    Wayne Clark; Fiscal Year: 2003
    ..The information obtained from this project will be critical in planning future clinical stroke trials involving these agents. ..
  46. Personality and Medication Adherence in Transplantation
    CAROL STILLEY; Fiscal Year: 2003
    ..medication regimes. The goal of the, a relatively new researcher, is to gain experience in order to develop more extensive study of psychological factors which better explain and predict treatment adherence after organ transplantation. ..
  47. Blood-Brain-CSF Barriers, CNS Homeostasis, Drug Delivery
    MARTHA O DONNELL; Fiscal Year: 2002
    ..It is also intended to have three open workshops/debates during the meeting. One is already in place on "Microdialysis". The maximum permitted attendance at this meeting is 150 scientists. ..
    Oscar Benavente; Fiscal Year: 2001
    ..abstract_text> ..
  49. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  50. Molecular Mechanisms of Ischemia
    Roger Simon; Fiscal Year: 2007
    ..abstract_text> ..
    Raj Kalaria; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Tissue Kallikrein, Oxidative Stress and Renal Fibrosis
    Julie Chao; Fiscal Year: 2007
    ..abstract_text> ..
  53. Rapid ischemic tolerance: Ubiquitin-mediated structural reorganization
    Robert Meller; Fiscal Year: 2007
    ..Indeed, the long-term aim of these studies is to discover endogenous protective mechanisms that can be translated into effective rapid acting neuroprotective agents for stroke. [unreadable] [unreadable] [unreadable]..
  54. Mechanisms of Axonal Sprouting After Stroke
    STANLEY CARMICHAEL; Fiscal Year: 2007
    ..These experiments will identify neuronal growth programs after stroke, and Iocal inhibitory molecules, and provide an understanding of the mechanisms of regeneration in the adult brain. ..
  55. Focal Brain Ischemia in the TNF-alpha-Transgenic Rat
    L Pettigrew; Fiscal Year: 2007
    ..investigation of TNF receptor (TNFR)-mediated signal transduction and cell death pathways activated during brain infarction in man...
    EUGENE GOLANOV; Fiscal Year: 2006
    ..abstract_text> ..
  57. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
  58. Mechanisms of Neuronal Regeneration after Stroke in a Novel Neurovascular Niche
    ..An understanding of the molecules that promote this neural stem cell response after stroke will help develop novel therapies to promote replacement of brain cells in this disease. ..
  59. Molecular determinants of epileptic brain injury
    Roger Simon; Fiscal Year: 2008
    ..brief, electrographically defined seizures, thereby offering novel, focused neuroprotective targets beyond anticonvulsants for treating at-risk epilepsy patients. ..
  60. Adherence & Health Outcomes after Liver Transplantation
    Carol S Stilley; Fiscal Year: 2010
    ..The application of this research would serve as the basis to advance significantly the nation's capacity to protect and preserve health in transplant populations. ..
  61. Outcomes of Perinatal Stroke
    Meredith Golomb; Fiscal Year: 2008
    ..During the last year of the study, she plans to apply for an R01 grant to set up a pilot clinical trial. [unreadable] [unreadable]..
  62. C1q-complement and hypoxic-ischemic injury in the developing brain.
    Vadim S Ten; Fiscal Year: 2010
    John Kessler; Fiscal Year: 2004
    ..These studies are likely to define mutations or polymorphisms associated with NTDs. The ability to identify genetic factors that place families at risk might help reduce the incidence of NTDs or make early intervention more feasible. ..
  64. Gene-Environment Interactions and Stroke Susceptibility
    Myriam Fornage; Fiscal Year: 2004
    ..We will also identify and characterize DNA variation in a panel of selected stroke-candidate human genes and test whether variation in these genes is associated with risk of developing a stroke in the ARIC sample. ..
    Myriam Fornage; Fiscal Year: 2004
    ..This collaborative effort is novel for its ability to translate unique animal model research findings to the human condition. ..