cerebrovascular accident


Summary: A sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. In general, cerebrovascular accidents are classified by anatomic location in the brain, vascular distribution, etiology, age of the affected individual, and hemorrhagic vs. nonhemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Top Publications

  1. ncbi European Stroke Initiative Recommendations for Stroke Management-update 2003
    Tom Skyhoj Olsen
    Cerebrovasc Dis 16:311-37. 2003
  2. ncbi An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis
    Hedley C A Emsley
    University of Manchester, Manchester, UK
    J Neuroimmunol 139:93-101. 2003
  3. ncbi The influence of early aerobic training on the functional capacity in patients with cerebrovascular accident at the subacute stage
    Michal Katz-Leurer
    Rehabilitation Department, Hadassah University Hospital, Jerusalem, Israel
    Arch Phys Med Rehabil 84:1609-14. 2003
  4. ncbi Thrombolysis for acute stroke in routine clinical practice
    Dawn M Bravata
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8025, USA
    Arch Intern Med 162:1994-2001. 2002
  5. ncbi Evidence for an association between air pollution and daily stroke admissions in Kaohsiung, Taiwan
    Shang Shyue Tsai
    Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Stroke 34:2612-6. 2003
  6. ncbi Long-term disability after first-ever stroke and related prognostic factors in the Perth Community Stroke Study, 1989-1990
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia
    Stroke 33:1034-40. 2002
  7. ncbi Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model
    Paula M Hughes
    Nervous System Research, Core Technology Area, Novartis Pharma AG, Basel, Switzerland
    J Cereb Blood Flow Metab 22:308-17. 2002
  8. pmc Dynamic cerebral autoregulation and beat to beat blood pressure control are impaired in acute ischaemic stroke
    P J Eames
    Division of Medicine for the Elderly, University of Leicester, Glenfield Hospital, Groby Road, Leicester, UK
    J Neurol Neurosurg Psychiatry 72:467-72. 2002
  9. ncbi Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients
    Max Wintermark
    Department of Diagnostic and Interventional Radiology, CHUV, Lausanne, Switzerland
    Ann Neurol 51:417-32. 2002
  10. ncbi A randomized controlled trial of early supported discharge and continued rehabilitation at home after stroke: five-year follow-up of patient outcome
    Ann Mari Thorsén
    Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden
    Stroke 36:297-303. 2005

Detail Information

Publications318 found, 100 shown here

  1. ncbi European Stroke Initiative Recommendations for Stroke Management-update 2003
    Tom Skyhoj Olsen
    Cerebrovasc Dis 16:311-37. 2003
    ..The recommendations are endorsed by the 3 European societies which are represented in the European Stroke Initiative: the European Stroke Council, the European Neurological Society and the European Federation of Neurological Societies...
  2. ncbi An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis
    Hedley C A Emsley
    University of Manchester, Manchester, UK
    J Neuroimmunol 139:93-101. 2003
  3. ncbi The influence of early aerobic training on the functional capacity in patients with cerebrovascular accident at the subacute stage
    Michal Katz-Leurer
    Rehabilitation Department, Hadassah University Hospital, Jerusalem, Israel
    Arch Phys Med Rehabil 84:1609-14. 2003
    To investigate the effect of early aerobic training on the aerobic and functional abilities of patients in the subacute stage of cerebrovascular accident (CVA).
  4. ncbi Thrombolysis for acute stroke in routine clinical practice
    Dawn M Bravata
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8025, USA
    Arch Intern Med 162:1994-2001. 2002
  5. ncbi Evidence for an association between air pollution and daily stroke admissions in Kaohsiung, Taiwan
    Shang Shyue Tsai
    Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Stroke 34:2612-6. 2003
    ..This study was undertaken to determine whether there is an association between air pollution and hospital admissions for stroke in Kaohsiung, Taiwan...
  6. ncbi Long-term disability after first-ever stroke and related prognostic factors in the Perth Community Stroke Study, 1989-1990
    Graeme J Hankey
    Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia
    Stroke 33:1034-40. 2002
    ..This population-based study aimed to describe disability, dependency, and related independent prognostic factors at 5 years after a first-ever stroke in patients in Perth, Western Australia...
  7. ncbi Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model
    Paula M Hughes
    Nervous System Research, Core Technology Area, Novartis Pharma AG, Basel, Switzerland
    J Cereb Blood Flow Metab 22:308-17. 2002
    ..The results of this study indicate that inhibition of MCP-1 signaling could be a new acute treatment approach to limit infarct size after stroke...
  8. pmc Dynamic cerebral autoregulation and beat to beat blood pressure control are impaired in acute ischaemic stroke
    P J Eames
    Division of Medicine for the Elderly, University of Leicester, Glenfield Hospital, Groby Road, Leicester, UK
    J Neurol Neurosurg Psychiatry 72:467-72. 2002
    ..This study assessed whether dCA is compromised after acute stroke using spontaneous blood pressure (BP) changes as the stimulus for the dCA response...
  9. ncbi Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients
    Max Wintermark
    Department of Diagnostic and Interventional Radiology, CHUV, Lausanne, Switzerland
    Ann Neurol 51:417-32. 2002
    ..It may also provide information about the extent of the penumbra. Perfusion CT could therefore be a valuable tool in the early management of acute stroke patients...
  10. ncbi A randomized controlled trial of early supported discharge and continued rehabilitation at home after stroke: five-year follow-up of patient outcome
    Ann Mari Thorsén
    Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden
    Stroke 36:297-303. 2005
    ..This study sought to evaluate the effect of early supported discharge and continued rehabilitation at home (ESD), in terms of patient outcome 5 years after stroke and changes in selected data over time...
  11. ncbi Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century
    Valery L Feigin
    Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    Lancet Neurol 2:43-53. 2003
  12. ncbi Stroke patients with atrial fibrillation have a worse prognosis than patients without: data from the Austrian Stroke registry
    Christina Steger
    II Med Department, Krankenanstalt Rudolfstiftung, Vienna, Austria
    Eur Heart J 25:1734-40. 2004
    ..Whether stroke patients with AF also have a higher rate of medical complications is unknown. The aim of the study was to compare the in-hospital course of acute stroke patients with and without AF...
  13. ncbi Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study
    L P Kammersgaard
    Department of Neurology, University Hospital Gentofte, Copenhagen, Denmark
    Stroke 33:1759-62. 2002
    ..In the present study, we investigated the predictive role of admission body temperature to the long-term mortality in stroke patients...
  14. ncbi Long term cost-of-illness in stroke: an international review
    Krista A Payne
    Caro Research Institute, Montreal, Quebec, Canada
    Pharmacoeconomics 20:813-25. 2002
    ..and Spanish literature was searched using the keywords stroke, ischaemic stroke, haemorrhagic stroke, cerebrovascular accident, cerebral infarction, cost(s), economics, and cost analysis...
  15. pmc Excess stroke in Mexican Americans compared with non-Hispanic Whites: the Brain Attack Surveillance in Corpus Christi Project
    Lewis B Morgenstern
    Stroke Program, University of Michigan Medical School, Ann Arbor, MI 48109 0316, USA
    Am J Epidemiol 160:376-83. 2004
    ..As the Mexican-American population grows and ages, measures to target this population for stroke prevention are critical...
  16. ncbi Sex differences in US mortality rates for stroke and stroke subtypes by race/ethnicity and age, 1995-1998
    Carma Ayala
    Cardiovascular Health Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Stroke 33:1197-201. 2002
    ..Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/ethnicity...
  17. ncbi Older stroke patients in Europe: stroke care and determinants of outcome
    A Bhalla
    Department of Public Health Sciences, GKT School of Medicine, London, UK
    Age Ageing 33:618-24. 2004
    ..in order to implement cost-effective stroke services for older patients, it is necessary to identify how stroke care is currently provided for these patients and how provision relates to outcome...
  18. ncbi Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
    Werner Hacke
    Medical University at Heidelberg, Germany
    Lancet 363:768-74. 2004
    ..Quick administration of intravenous recombinant tissue plasminogen activator (rt-PA) after stroke improved outcomes in previous trials. We aimed to analyse combined data for individual patients to confirm the importance of rapid treatment...
  19. ncbi A systematic review of barriers to delivery of thrombolysis for acute stroke
    Joseph Kwan
    University Department of Geriatric Medicine, Level E MP807, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Age Ageing 33:116-21. 2004
    ..Barriers within the patient pathway can prevent early administration of thrombolytic therapy in patients admitted with acute stroke. This systematic review aimed to identify such barriers that have been reported in the medical literature...
  20. ncbi Is the association of National Institutes of Health Stroke Scale scores and acute magnetic resonance imaging stroke volume equal for patients with right- and left-hemisphere ischemic stroke?
    John N Fink
    Beth Israel Deaconess Medical Center, Boston, Mass, USA
    Stroke 33:954-8. 2002
    ..The aim of this study was to investigate whether the relationship between acute NIHSS score and acute stroke volume as determined by acute diffusion- and perfusion-weighted MRI (DWI and PWI) differs between right- and left-sided stroke...
  21. ncbi Air pollution: a new risk factor in ischemic stroke mortality
    Yun Chul Hong
    Department of Occupational and Environmental Medicine, Inha University College of Medicine, Jung Gu, Incheon, Korea
    Stroke 33:2165-9. 2002
    ..We investigated the association between acute stroke mortality and air pollution over a 7-year period (January 1991 through December 1997) in Seoul, Korea...
  22. ncbi Neuroprotection in cerebral ischaemia: facts and fancies--the need for new approaches
    Nils Gunnar Wahlgren
    Stroke Research Unit, Department of Neurology, Karolinska Hospital, Stockholm, Sweden
    Cerebrovasc Dis 17:153-66. 2004
    ..This article will summarize neuroprotection trials to date, some facts and fancies about neuroprotection, ischaemic pathophysiology and possible reasons for the apparent failure of human neuroprotective stroke trials...
  23. ncbi Incidence of cerebral hemorrhage in the Changsha community. A prospective study from 1986 to 2000
    Qi Dong Yang
    Department of Neuroepidemiology, Institute of Neurology, The Xiangya Hospital, Central South University, Changsha, People s Republic of China
    Cerebrovasc Dis 17:303-13. 2004
    ..To provide information for preventing and managing ICH, we undertook this study supervising and determining the annual first-ever average incidence of cerebral hemorrhage from 1986 to 2000 in Changsha...
  24. ncbi Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomis
    Peter S Sever
    Imperial College, London, UK
    Lancet 361:1149-58. 2003
    ..No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemic...
  25. ncbi Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke
    Jenny Crinion
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Brain 128:2858-71. 2005
    ..In addition, they highlight the importance of the right anterior superior temporal cortex where the response was dissociated from that in the left posterior temporal lobe...
  26. ncbi Blood pressure and clinical outcomes in the International Stroke Trial
    Jo Leonardi-Bee
    Centre for Vascular Research, University of Nottingham, Nottingham, UK
    Stroke 33:1315-20. 2002
  27. ncbi Evaluating the genetic component of ischemic stroke subtypes: a family history study
    Paula Jerrard-Dunne
    Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK
    Stroke 34:1364-9. 2003
    ..We determined the familial aggregation of stroke risk in different stroke phenotypes and used the results to model estimated sample size requirements for case-control studies...
  28. ncbi Decreased frequencies of ABCA1 polymorphisms R219K and V771M in Hungarian patients with cerebrovascular and cardiovascular diseases
    Hajnalka Andrikovics
    Department of Molecular Genetics, National Medical Center, Budapest, Hungary
    Cerebrovasc Dis 21:254-9. 2006
    ..Genetic polymorphisms in ABC transporter A1 (ABCA1) may alter the regulation of plasma high-density lipoprotein (HDL), promoting or protecting from vascular diseases...
  29. ncbi Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging study
    Susanne Wegener
    Department of Neurology, University Hospital Charite, Schumannstrasse 20 21, 10117 Berlin, Germany
    Stroke 35:616-21. 2004
    ..We investigated whether transient ischemic attacks (TIAs) before stroke can induce tolerance by raising the threshold of tissue vulnerability in the human brain...
  30. ncbi Elevated plasma homocysteine in acute stroke was not associated with severity and outcome: stronger association with small artery disease
    F Perini
    Headache and Stroke Center, Department of Neurology, St Bortolo Hospital, ULSS 6, Vicenza, Italy
    Neurol Sci 26:310-8. 2005
    ..Elevated plasma homocysteine in the acute phase of stroke was associated with both ischaemic and haemorrhagic stroke. Higher levels are associated with higher risk of small artery disease subtype of stroke...
  31. ncbi Short-term, intermediate-term, and long-term mortality in patients hospitalized for stroke
    Tracie C Collins
    Houston Center for Quality Care and Utilization Studies, 2002 Holcombe Blvd 152, Houston, TX 77030, USA
    J Clin Epidemiol 56:81-7. 2003
    ..Further work is needed to assess the impact of actual care patterns, for the above identified risk factors, on stroke prognosis over varying time periods...
  32. ncbi Stroke research in China
    Gangzhi Wei
    Department of Neurology, Xuanwu Hospital, The Capital University of Medical Sciences, Beijing 100053, China
    Neurol Res 28:11-5. 2006
  33. ncbi Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial
    K W Muir
    Lancet 363:439-45. 2004
    ..We aimed to test whether intravenous magnesium sulphate, given within 12 h of stroke onset, reduces death or disability at 90 days...
  34. ncbi Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Stroke 34:975-81. 2003
    ..Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs)...
  35. ncbi Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study
    Hok Hay S Oei
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 111:570-5. 2005
    ..In the present study, we investigated whether Lp-PLA2 is an independent predictor of coronary heart disease and ischemic stroke...
  36. ncbi High-dose atorvastatin after stroke or transient ischemic attack
    Pierre Amarenco
    Denis Diderot University, Paris
    N Engl J Med 355:549-59. 2006
    ..Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established...
  37. ncbi Multicenter comparison of processes of care between Stroke Units and conventional care wards in Australia
    Dominique A Cadilhac
    National Stroke Research Institute, Level 1 Neurosciences Building, Repatriation Hospital, 300 Waterdale Road, Heidelberg Heights, Victoria, Australia 3081
    Stroke 35:1035-40. 2004
    ..Reasons may include greater adherence to processes of care (PoC). The primary hypothesis was that adherence to selected PoC is greater in SUs than in other acute care models...
  38. ncbi Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke
    Jieli Chen
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Ann Neurol 53:743-51. 2003
    ..Atorvastatin also induced phosphorylation of Akt and Erk in cultured primary cortical neurons. These data indicate that atorvastatin induced brain plasticity and has neurorestorative activity after experimental stroke...
  39. ncbi Short- and long-term prognosis for very old stroke patients. The Copenhagen Stroke Study
    Lars Peter Kammersgaard
    Stroke Unit, Hvidovre University Hospital, Copenhagen, Denmark
    Age Ageing 33:149-54. 2004
    ..The aims of this study were to evaluate clinical characteristics of patients aged 85 years or more at stroke onset and to investigate very old age as an independent predictor of short- and long-term outcome...
  40. ncbi Early impairment in consciousness predicts mortality after hemispheric ischemic stroke
    Brett L Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
    Crit Care Med 32:241-5. 2004
    ..Early predictors of poor outcome after acute ischemic stroke may be useful in selecting patients for potentially beneficial but high-risk interventions...
  41. ncbi A longitudinal fMRI study: in recovering and then in clinically stable sub-cortical stroke patients
    David Tombari
    INSERM U455, Pavillon Riser, Hopital Purpan, 31059 Toulouse, France
    Neuroimage 23:827-39. 2004
  42. ncbi Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia
    Carolina M Maier
    Department of Neurosurgery, University School of Medicine, Stanford, Calif 94305 5487, USA
    Stroke 35:1169-74. 2004
    ..Here we examined the spatial-temporal relation between MMP-9 expression and neutrophil infiltration after stroke...
  43. ncbi Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature
    Andreas Kastrup
    Department of Neurology, University of Tubingen, Tubingen, Germany
    Stroke 34:813-9. 2003
  44. ncbi Blood pressure and vessel recanalization in the first hours after ischemic stroke
    Heinrich P Mattle
    Department of Neurology, University of Berne, Freiburgstrasse, Inselspital, CH 3010 Berne, Switzerland
    Stroke 36:264-8. 2005
    ..Transient elevation of arterial blood pressure (BP) is frequent in acute ischemic stroke and may help to increase perfusion of tissue jeopardized by ischemia. If this is true, recanalization may eliminate the need for this BP elevation...
  45. ncbi Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059
    A Richard Green
    AstraZeneca R and D Charnwood, Bakewell Road, Loughborough, Leics LE11 5RH, UK
    Pharmacol Ther 100:195-214. 2003
    ..NXY-059 may thus be the first compound to be examined in stroke patients using drug exposure and time to treatment that have been shown to be effective in animal models of stroke...
  46. ncbi Calcium channel blockade to prevent stroke in hypertension: a meta-analysis of 13 studies with 103,793 subjects
    Fabio Angeli
    Departments of Cardiovascular Disease and Internal Medicine, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 17:817-22. 2004
    ..We undertook a meta-analysis to assess whether calcium channel blockers (CCBs) are associated with a lesser risk of stroke as compared with other antihypertensive drugs...
  47. ncbi A comparison of rate control and rhythm control in patients with atrial fibrillation
    D G Wyse
    AFFIRM Clinical Trial Center, Axio Research, 2601 4th Ave, Ste 200, Seattle, WA 98121, USA
    N Engl J Med 347:1825-33. 2002
    ..In both approaches, the use of anticoagulant drugs is recommended...
  48. ncbi Access to care, acculturation, and risk factors for stroke in Mexican Americans: the Brain Attack Surveillance in Corpus Christi (BASIC) project
    Melinda A Smith
    Stroke Program, University of Michigan Health System, Ann Arbor, USA
    Stroke 34:2671-5. 2003
    ..We compared access to care, acculturation, and biological risk factors among Mexican American and non-Hispanic white stroke patients and the general population...
  49. ncbi Utility of the NIH Stroke Scale as a predictor of hospital disposition
    Daniel Schlegel
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Stroke 34:134-7. 2003
    ..The NIH Stroke Scale (NIHSS) is an attractive candidate predictor of disposition because it is widely used, is easily learned, and can be performed rapidly on admission...
  50. ncbi Thrombolytic therapy with recombinant tissue plasminogen activator for acute ischemic stroke: where do we go from here? A cumulative meta-analysis
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Stroke 34:1437-42. 2003
    ..Recombinant tissue plasminogen activator (rtPA; Actilyse) is not as widely used in clinical practice as it could be. Have new data since 1995 strengthened the evidence sufficiently to justify more widespread use of rtPA?..
  51. ncbi Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-up
    Emmanouil S Brilakis
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 26:137-44. 2005
    ..We aimed to evaluate the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) with coronary artery disease (CAD) risk factors, with the severity of angiographic CAD, and with the incidence of major adverse events...
  52. ncbi Predictors of in-hospital mortality and attributable risks of death after ischemic stroke: the German Stroke Registers Study Group
    Peter U Heuschmann
    Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany
    Arch Intern Med 164:1761-8. 2004
    ..We investigated predictors for in-hospital mortality and attributable risks of death after ischemic stroke in a pooled analysis of large German stroke registers...
  53. ncbi Risk of hospitalized stroke in men enrolled in the Honolulu Heart Program and the Framingham Study: A comparison of incidence and risk factor effects
    Beatriz L Rodriguez
    Division of Clinical Epidemiology, John A Burns School of Medicine, University of Hawaii at Manoa, USA
    Stroke 33:230-6. 2002
    ..Our purpose was to compare the 20-year incidence of hospitalized stroke between Japanese-American men in the Honolulu Heart Program and white men in the Framingham Study...
  54. ncbi Effect of socioeconomic status on treatment and mortality after stroke
    Moira K Kapral
    Institute for Clinical Evaluative Sciences, University Health Network University of Toronto, Ontario, Canada
    Stroke 33:268-73. 2002
    ..Socioeconomic status is associated with increased mortality from ischemic heart disease. We undertook a study to determine whether a similar association exists between socioeconomic status and stroke mortality...
  55. ncbi Improving delivery of acute stroke therapy: The TLL Temple Foundation Stroke Project
    Lewis B Morgenstern
    Stroke Program, Department of Neurology, University of Texas Medical School, Houston 77030, USA
    Stroke 33:160-6. 2002
    ..We performed a community and professional behavioral intervention project to increase the proportion of stroke patients treated with approved acute stroke therapy...
  56. ncbi Self-reported stress and risk of stroke: the Copenhagen City Heart Study
    Thomas Truelsen
    Institute of Preventive Medicine, Kommune Hospitalet, Copenhagen K, Denmark
    Stroke 34:856-62. 2003
    ..To examine these possibilities, we analyzed the association between self-reported stress frequency and intensity and risk of stroke...
  57. ncbi Influence of somatosensory input on motor function in patients with chronic stroke
    Agnes Floel
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 56:206-12. 2004
  58. ncbi Carotid artery stenting is associated with increased complications in octogenarians: 30-day stroke and death rates in the CREST lead-in phase
    Robert W Hobson
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07101, USA
    J Vasc Surg 40:1106-11. 2004
    ..The occurrence of stroke and death was reviewed by an independent clinical events committee...
  59. ncbi Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke
    Stefan Schwarz
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:497-501. 2002
    ..The purpose of this study was to prospectively evaluate the effects of body position in patients with large supratentorial stroke...
  60. ncbi Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial
    Jeffrey L Saver
    UCLA Stroke Center, Geffen School of Medicine of the University of California, Los Angeles 90095, USA
    Stroke 35:e106-8. 2004
    ..To demonstrate that paramedic initiation of intravenous magnesium sulfate (Mg) in the field in focal stroke patients is feasible, safe, and yields significant time-savings compared with in-hospital initiation of neuroprotective therapy...
  61. ncbi The latest on functional imaging studies of aphasic stroke
    Cathy J Price
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Curr Opin Neurol 18:429-34. 2005
    ..In this review of studies published between January 2004 and February 2005, we discuss imaging studies of speech production and comprehension in patients with aphasia after left hemisphere stroke...
  62. ncbi Incidence and trends of stroke and its subtypes in China: results from three large cities
    Bin Jiang
    Department of Neuroepidemiology, Beijing Neurosurgical Institute, Beijing 100050, P R China
    Stroke 37:63-8. 2006
    ..To examine the incidence and trends of stroke and its major subtypes during the 1990s in 3 cities in China...
  63. ncbi The effect of pneumonia on mortality among patients hospitalized for acute stroke
    I L Katzan
    Center for Health Care Research and Policy, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    Neurology 60:620-5. 2003
    ..To determine the effect of pneumonia on 30-day mortality in patients hospitalized for acute stroke...
  64. ncbi Multiple levels of regulation of the interleukin-6 system in stroke
    Daniela Acalovschi
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 34:1864-9. 2003
    ..The purpose of this study was to investigate whether serum levels of the receptor subunits are changed after ischemic stroke and to define the role of genetic influences on IL-6 expression in acute stroke...
  65. ncbi Analysis of fMRI and finger tracking training in subjects with chronic stroke
    James R Carey
    Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA
    Brain 125:773-88. 2002
    ..We concluded that individuals with chronic stroke receiving intensive tracking training showed improved tracking accuracy and grasp and release function, and that these improvements were accompanied by brain reorganization...
  66. ncbi Persisting consequences of stroke measured by the Stroke Impact Scale
    Sue Min Lai
    Department of Preventive Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7313, USA
    Stroke 33:1840-4. 2002
  67. ncbi Tissue plasminogen activator for acute ischemic stroke in clinical practice: a meta-analysis of safety data
    Glenn D Graham
    Albuquerque VA and University of New Mexico School of Medicine, Department of Neurology, VA Medical Center, Albuquerque, NM 87122, USA
    Stroke 34:2847-50. 2003
    ..Numerous case series of clinical experience with tPA have been published that provide additional data on the safety of thrombolytic therapy...
  68. ncbi Emergency calls in acute stroke
    Rene Handschu
    Department of Neurology, Friedrich Alexander Universitaet, Erlangen Nurnberg, Erlangen, Germany
    Stroke 34:1005-9. 2003
    ..Subsequently, early recognition of stroke symptoms and rapid activation of the medical system are essential. We sought to investigate what witnesses or victims of an acute stroke syndrome recognize and report in the actual situation...
  69. ncbi Burden of first-ever ischemic stroke in the oldest old: evidence from a population-based study
    C Marini
    Clinica Neurologica, Universita degli Studi di L Aquila, Italy
    Neurology 62:77-81. 2004
    ..To evaluate the contribution of subjects 80 years old or older to the burden of ischemic stroke as compared with subjects younger than 80 years...
  70. ncbi Strengthening acute stroke trials through optimal use of disability end points
    Fiona B Young
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, Scotland
    Stroke 34:2676-80. 2003
    ..The Barthel Index (BI) and Rankin Scale (RS) have been widely used and analyzed in various ways. We sought to investigate the most powerful end point for use in acute stroke trials...
  71. ncbi The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 36:233-9. 2004
    ..We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall...
  72. ncbi A pilot randomized trial of induced blood pressure elevation: effects on function and focal perfusion in acute and subacute stroke
    A E Hillis
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Cerebrovasc Dis 16:236-46. 2003
    ..We conducted a pilot, randomized trial to evaluate effects of pharmacologically induced blood pressure elevation on function and perfusion in acute stroke...
  73. ncbi Family history in ischemic stroke before 70 years of age: the Sahlgrenska Academy Study on Ischemic Stroke
    Katarina Jood
    Institute of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
    Stroke 36:1383-7. 2005
    ..Accordingly, we investigated stroke subtypes, vascular risk factors, and family history in a large study of patients with ischemic stroke onset before age 70 years...
  74. pmc Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study
    Shah Ebrahim
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 333:22. 2006
    ..To investigate risk factors, such as heavy alcohol consumption, that might explain any increased risk of haemorrhagic stroke associated with low blood cholesterol...
  75. ncbi Stroke care delivery in institutions participating in the Registry of the Canadian Stroke Network
    Moira K Kapral
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Stroke 35:1756-62. 2004
    ..Guidelines and performance indicators have been established for acute stroke care. However, little is known about the process of stroke care delivery in Canada...
  76. ncbi Validating administrative data in stroke research
    David L Tirschwell
    Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104 2499, USA
    Stroke 33:2465-70. 2002
    ..Research based on administrative data has advantages, including large numbers, consistent data, and low cost. This study was designed to compare different methods of stroke classification using administrative data...
  77. ncbi Alcohol consumption and risk of stroke: a meta-analysis
    Kristi Reynolds
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave SL18, New Orleans, LA 70112, USA
    JAMA 289:579-88. 2003
    ..Observational studies suggest that heavy alcohol consumption may increase the risk of stroke while moderate consumption may decrease the risk...
  78. ncbi Transient detection of early wallerian degeneration on diffusion-weighted MRI after an acute cerebrovascular accident
    A Uchino
    Department of Radiology, Saga Medical School, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    Neuroradiology 46:183-8. 2004
    We report three patients with a cerebrovascular accident studied serially by MRI, including diffusion-weighted imaging (DWI)...
  79. ncbi Potential confounding by intermediate phenotypes in studies of the genetics of ischaemic stroke
    Enrico Flossmann
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford 0X2 6HE, UK
    Cerebrovasc Dis 19:1-10. 2005
    ..We studied FHx of ischaemic heart disease (IHD), hypertension (HTN) and diabetes mellitus (DM) as risk factors for ischaemic stroke...
  80. ncbi Association between diabetes and stroke subtype on survival and functional outcome 3 months after stroke: data from the European BIOMED Stroke Project
    Salah Eddine Megherbi
    Stroke Registry of Dijon, Faculty of Medicine of Dijon, Burgundy University, Dijon, France
    Stroke 34:688-94. 2003
    ..We sought to evaluate stroke features, prognosis, and functional outcome in patients with diabetes compared with patients without diabetes...
  81. ncbi Magnetic resonance imaging findings of presumed cerebellar cerebrovascular accident in twelve dogs
    J F McConnell
    Animal Health Trust, Newmarket, Centre for Small Animal Studies, Suffolk CB8 7UU, UK
    Vet Radiol Ultrasound 46:1-10. 2005
    The magnetic resonance imaging (MRI) findings of presumed cerebrovascular accident in 12 dogs are described. Fourteen lesions were seen, commonly (11 of 14) within the gray matter of the cerebellar hemispheres or vermis...
  82. pmc Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome
    Craig J Smith
    University of Manchester, Manchester M13 9PT, UK
    BMC Neurol 4:2. 2004
    ..We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome...
  83. ncbi The combined effect of paraoxonase promoter and coding region polymorphisms on the risk of arterial ischemic stroke among young adults
    Barbara Voetsch
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    Arch Neurol 61:351-6. 2004
    ..Interindividual variability in PON1 levels is determined by the Q192R and L55M coding region polymorphisms and by 2 recently described polymorphisms in the promoter of the PON1 gene, C(-107)T and G(-824)A...
  84. ncbi Effects of introducing an integrated care pathway in an acute stroke unit
    Joseph Kwan
    Western General Hospital, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Age Ageing 33:362-7. 2004
    ..We sought to evaluate the effects of introducing an integrated care pathway for acute stroke...
  85. ncbi Risk of ischemic stroke with tamoxifen treatment for breast cancer: a meta-analysis
    Cheryl D Bushnell
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 63:1230-3. 2004
    ..To assess the overall risk of stroke, specifically ischemic stroke, associated with tamoxifen use by performing a meta-analysis of data reported in breast cancer trials...
  86. ncbi Overt naming in aphasia studied with a functional MRI hemodynamic delay design
    Paula I Martin
    Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine, MA 02130, USA
    Neuroimage 28:194-204. 2005
    ..This method permitted verification that the patients were cooperating with the task during fMRI. It has application for future fMRI studies of overt speech in aphasia...
  87. pmc A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients
    H C A Emsley
    Division of Neuroscience, The University of Liverpool, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    J Neurol Neurosurg Psychiatry 76:1366-72. 2005
    ..We report here the first randomised, double blind, placebo controlled trial of recombinant human IL-1ra (rhIL-1ra) in patients with acute stroke...
  88. ncbi Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults
    Barbara Voetsch
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
    Stroke 33:1459-64. 2002
    ..The association of these polymorphisms with the risk of AIS remains controversial...
  89. ncbi Posture control in Pusher syndrome: influence of lateral semicircular canals
    Taiza Elaine Grespan dos Santos Pontelli
    Braz J Otorhinolaryngol 71:448-52. 2005
    ..The role of vestibular system on the pushing behavior is not clear...
  90. ncbi Therapeutic effects of suburothelial injection of botulinum a toxin for neurogenic detrusor overactivity due to chronic cerebrovascular accident and spinal cord lesions
    Hann Chorng Kuo
    Department of Urology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Urology 67:232-6. 2006
    To investigate the therapeutic effects of suburothelial botulinum A toxin for patients with chronic cerebrovascular accident (CVA) and spinal cord lesions...
  91. ncbi Community participation following cerebrovascular accident: impact of the buffering model of social support
    Margaret Newsham Beckley
    The Ohio State University, College of Medicine and Public Health, School of Allied Medical Professions, 453 West Tenth Avenue, Columbus, Ohio 43210, USA
    Am J Occup Ther 60:129-35. 2006
    ..The findings indicate that for people who had sustained a cerebrovascular accident, community participation was more related to their ability to do for themselves, rather than the support ..
  92. ncbi Reduction of spastic hypertonia during repeated passive knee movements in stroke patients
    Godelieve E Nuyens
    Department of Rehabilitation Sciences, Faculty of Physical Education and Physiotherapy, University of Leuven, Belgium
    Arch Phys Med Rehabil 83:930-5. 2002
    ..To quantify changes in spastic hypertonia during repeated passive isokinetic knee movements in stroke patients and to assess the role of muscle activity...
  93. pmc The Siblings With Ischemic Stroke Study (SWISS): a progress report
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Clin Med Res 4:12-21. 2006
    ..This report updates the progress of enrollment in the SWISS protocol, discusses barriers to pedigree completion and describes innovative approaches used by the SWISS investigators to enhance enrollment...
  94. ncbi Impact of early vs delayed admission to rehabilitation on functional outcomes in persons with stroke
    Katherine Salter
    Department of Physical Medicine and Rehabilitation, Parkwood Hospital, St Joseph s Health Centre, London, Ontario, Canada
    J Rehabil Med 38:113-7. 2006
    ..The present study examined the effects of early vs delayed admission on functional outcome and length of stay in patients admitted to a rehabilitation unit for first-ever unilateral stroke...
  95. ncbi Cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction and cerebrovascular accident
    N S Abraham
    Houston Center for Quality of Care and Utilization Studies, and Deparment of Gastroenterology, Michael E DeBakey VAMC and Baylor College of Medicine, Houston, TX 77030, USA
    Aliment Pharmacol Ther 25:913-24. 2007
    To assess degree of cyclooxygenase-2 (COX-2) selectivity of a non-steroidal anti-inflammatory drug (NSAID) and risk of myocardial infarction (MI) or cerebrovascular accident (CVA).
  96. ncbi Motor imagery: a backdoor to the motor system after stroke?
    Nikhil Sharma
    Department of Clinical Neurosciences, University of Cambridge, England
    Stroke 37:1941-52. 2006
    ..Specifically, whether the primary motor cortex (M1), considered a prime target of poststroke rehabilitation, is involved in motor imagery is unresolved...
  97. ncbi Lifetime cost of stroke subtypes in Australia: findings from the North East Melbourne Stroke Incidence Study (NEMESIS)
    Helen M Dewey
    National Stroke Research Institute, Level 1, Neurosciences Bldg, Repatriation Campus, Austin and Repatriation Medical Centre, 300 Waterdale Rd, Heidelberg Heights, Victoria 3081, Australia au
    Stroke 34:2502-7. 2003
    ..The purpose of this study was to describe the patterns of resource use and to estimate the first-year and lifetime costs for stroke subtypes...
  98. ncbi Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis
    Carl van Walraven
    Clinical Epidemiology Unit, Ottawa Health Research Institute, F 6, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 288:2441-8. 2002
    ..Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events...
  99. pmc Ischemia-reperfusion-related repair deficit after oxidative stress: implications of faulty transcripts in neuronal sensitivity after brain injury
    Philip K Liu
    Departments of Neurosurgery and Molecular and Cell Biology and Cardiovascular Disease Program of the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Biomed Sci 10:4-13. 2003
    ..This suggests that the accuracy of gene expression could be accounted for the recovery of cellular function after cerebral injury...
  100. ncbi Serial changes in static and dynamic cerebral autoregulation after acute ischaemic stroke
    Suzanne L Dawson
    University Division of Medicine for the Elderly, Leicester Warwick Medical School, University of Leicester, UK
    Cerebrovasc Dis 16:69-75. 2003
    ..The longitudinal changes in static and dynamic cerebral autoregulation (CA) following acute ischaemic stroke are unknown and were assessed in this study...
  101. ncbi Increased risk of heart disease and stroke among foreign-born females residing in the United States
    Maria Rubia
    New School University, Milano Graduate School, New York, NY 10011, USA
    Am J Prev Med 22:30-5. 2002
    ..This article provides an update of mortality rates among the foreign born in the United States and, in particular, examines mortality rates from heart disease among foreign-born females...

Research Grants72

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Nervous System Diseases/*therapy</keyword;keyword>Cerebrovascular Accident/therapy</keyword;keyword>Clinical Trials</keyword;keyword>Epilepsy/therapy</keyword;..
  2. Deacetylation of mitochondrial proteins protect neurons from ischemic injury
    Conrad Alano; Fiscal Year: 2013
  3. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2012
    ..Therefore, in the current application, we propose to investigate the neuroprotective effects of VELCADE alone and incombination with tPA and the mechanisms underlying the beneficial effects in aged rats after embolic stroke. ..
  4. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..hNSCs following peripheral administration 24 hrs post-stroke, particularly under conditions where their homing has been optimized by fucosylation. ..
  5. Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicity
    Robert Meller; Fiscal Year: 2012
    ..It is our aim to investigate these mechanisms to help develop new therapeutics for stroke, or for circumstances where ischemia can be predicted, such as heart bypass surgery. ..
  6. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..If successful, the findings of these exploratory studies will be used in near future translational studies designed to optimize tVNS treatment for acute ischemic stroke in humans. ..
  7. Development of Potent/Selective Lipoxygenase Therapeutics Against Stroke Injury
    Theodore R Holman; Fiscal Year: 2013
    ..Considering that our "validated hit" manifests a 30% reduction in infarct size, we are confident these studies will discover a 12/15- LOX inhibitor as an effective therapeutic against stroke damage. ..
  8. Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for Stroke
    Irina Y Sazonova; Fiscal Year: 2012
    ..In this project we propose a novel thrombolytic agent and plan to determine its efficacy for the treatment in an experimental model of thromboembolic cerebral ischemia. ..
  9. Enhanced Risk Adjustment Using Laboratory Test and Pharmacy Data
    Amresh Hanchate; Fiscal Year: 2013
    ..abstract_text> ..
  10. Ac-SDKP for Treatment of Acute Stroke
    Zheng Gang Zhang; Fiscal Year: 2013
    ..These studies could potentially provide a new therapy to minimize the adverse effect of tPA on ischemic neurovascular damage, leading to improved neurological outcomes after acute stroke. ..
  11. TWEAK-Induced Neuroinflammation and Cerebral Edema
    MANUEL SALVADOR YEPES; Fiscal Year: 2013
    ..Importantly, if our hypothesis is correct, our findings should indicate whether inhibition of TWEAK-Fn4 binding is a valid new target for the treatment of patients with acute ischemic stroke. ..
  12. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013
    ..Noninvasive 'Image-Guided Sonothrombolysis'at the bedside or even in the ambulance vehicle would be a major achievement in stroke therapy. ..
  13. Role of Hyperglycemia in Intracerebral Hemorrhage
    Edward P Feener; Fiscal Year: 2013
    ..This grant will examine the hypothesis that the direct effects of plasma kallikrein on hemostasis and peri-hematomal edema contribute to the poor ICH outcomes in diabetes and hyperglycemia. ..
  14. Thrombin Mediated Cytotoxicity during Cerebral Ischemia
    Patrick D Lyden; Fiscal Year: 2013
  15. Targeting the Pial Collateral Circulation for Mitigation of Cerebral Ischemia
    James E Faber; Fiscal Year: 2013
    ..Identifying this major allele that when polymorphic impairs collateral formation may also provide a genetic marker for use in these same patient groups. ..
  16. New York-Presbyterian NETT Consortium
    Stephan A Mayer; Fiscal Year: 2011
  17. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..Our findings will be relevant to the development of novel therapeutic strategies targeting pro- inflammatory pathways in AD. ..
    ANDRIA LEE FORD; Fiscal Year: 2013
    ..Additionally, we will examine variables that may modify these thresholds of injury, including time-to-imaging, tissue type (gray vs. white matter), and baseline clinical characteristics. ..
  19. A multiethnic comparative effectiveness study for diagnosis of cardiogenic stroke
    Jeffrey R Gulcher; Fiscal Year: 2011
    ..Improved detection of atrial fibrillation, especially in patients who have had a recent stroke may substantially decrease both the recurrent stroke rate and the cost of healthcare. ..
  20. Phase II Trial of Tiopronin in Aneurysmal Subarachnoid Hemorrhage
    EDWARD SANDER CONNOLLY; Fiscal Year: 2011
    ..This would spark further study that could further explore neuroprotective pre-treatment of cerebral ischemia, and thus help neutralize a major source of morbidity and mortality in this disease process. ..
  21. Racial & Ethnic Disparities in Incidence and Inpatient Outcomes of Acute Stroke
    Amresh D Hanchate; Fiscal Year: 2010
    ..For effective targeting of interventions and public policy, our study aims to use evidence to identify and prioritize modifiable factors appropriate for each minority cohort. ..
  22. Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (I-SPOT)
    ANGARA KONETI RAO; Fiscal Year: 2013
  23. Examining Vascular Regulation Following Acute Stroke
    Sandra Billinger; Fiscal Year: 2013
    ..However, before a clinical trial is undertaken, it is important and essential that one understands the role of pro-inflammatory markers and vascular function during stroke recovery. ..
  24. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2010
  25. ARFI ultrasound for noninvasive, Diagnostic atherosclerosis imaging
    Caterina M Gallippi; Fiscal Year: 2013
    ..Furthermore, their ability to predict plaque risk for causing cerebrovascular accident (CVA) has not been well established (Raggi et al 2005)...
  26. Diffuse Optics for Acute Stroke Management
    Arjun G Yodh; Fiscal Year: 2012
    ..abstract_text> ..
  27. The epidemiology of sleep apnea in a bi-ethnic stroke population
    Lynda D Lisabeth; Fiscal Year: 2013
    Jeffrey L Saver; Fiscal Year: 2012
    ..A Career Development Program will train the next generation of translational scientists in neurovascular disease at the premedical, medical student, and fellowship level. ..
  29. Microglial Toll-like Receptor-4 and Ischemic Preconditioning
    Jonathan R Weinstein; Fiscal Year: 2013
    ..A major goal of this research project is to increase our mechanistic understanding of stroke pathophysiology. By doing so, we hope to identify novel cellular and molecular targets for therapeutic intervention in acute stroke. ..
  30. Metabolomic analysis of acute stress hyperglycemia in ischemic stroke
    WILLIAM TAYLOR KIMBERLY; Fiscal Year: 2013
    ..Kimberly with the skills that are essential for him to develop an independent career in cerebrovascular research at the cutting edge of science. ..
  31. The New York City Collaborative Regional Coordinating Stroke Center
    Stanley Tuhrim; Fiscal Year: 2013
    ..Three rehabilitation hospitals, including the preeminent Rusk Institute at NYU, Beth Abraham at Einstein and the Rehabilitation Center at ISMMS are also key network partners. ..
  32. Cyclooxygenase 2 and Ischemic Neuronal Injury
    Steven H Graham; Fiscal Year: 2012
    ..The current project aims to identify a downstream mechanism by which COX2 activity injures neurons which could lead to new treatments for stroke and neurodegenerative diseases. ..
  33. Electrical stimulation of motor cortex: a candidate adjuvant to stroke therapy?
    JAMES WILLIAM STINEAR; Fiscal Year: 2010
    ..The proposed research has the potential to develop a safe, low-cost, easily administered auxiliary treatment for walking retraining that could promote a major increase in walking ability and independence following stroke. ..
  34. Acute Stroke Program of Interventions: Racial &Ethnic Disparities(ASPIRE)
    CHELSEA M KIDWELL; Fiscal Year: 2011
    ..abstract_text> ..
  35. Stroke Treatment by Chemically-Induced Hypothermia
    Shan Ping Yu; Fiscal Year: 2012
    ..Our ultimate goal is to advance the drug-induced hypothermia therapy to the clinic. ..
  36. Field Administration of Stroke Therapy-Magnesium Trial (FAST-MAG)
    Jeffrey L Saver; Fiscal Year: 2013
  37. Establishment of fast pH MRI for imaging metabolic injury during acute stroke
    Phillip Zhe Sun; Fiscal Year: 2013
  38. Development and Validation of a VA Stroke Swallowing Screening Tool
    STEPHANIE KAY DANIELS; Fiscal Year: 2013
  39. New England Regional Coordinating Center for the NINDS Stroke Trials Network
    Lee H Schwamm; Fiscal Year: 2013
    ..Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1, 2 and 3 studies. ..
  40. Washington University SPOTRIAS Center
    COLIN PIETER DERDEYN; Fiscal Year: 2012
    ..Finally, we will evaluate a novel MR sequence for the determination of cerebral oxygenation (Project 3). This has promise as a method to reliably identify injured tissue that will progress to infarction without therapy. ..
  41. Imaging Study of Combination Thrombolytic Therapy
    GEORGE JEROME SHAW; Fiscal Year: 2010
    ..The results of this work could easily be taken from "bench to bedside" by virtue of the candidate's ongoing collaboration with Greater Cincinnati/Northern Kentucky stroke team. ..
  42. Mechanisms of Vascular Protection after Acute Stroke
    Susan C Fagan; Fiscal Year: 2013
    ..This project will determine the mechanisms of vascular protection after stroke and develop a medication treatment likely to work in stroke patients. ..
  43. PHILA-NETT: Neurological Emergencies Treatment Trials (NETT) Network Clinical Hub
    Nina T Gentile; Fiscal Year: 2013
  44. South Carolina Collaborative Alliance for Stroke Trials (SC-CoAST)
    Edward C Jauch; Fiscal Year: 2013
  45. Specialized Programs of Translational Research in Acute Stroke at the Partners
    Steven M Greenberg; Fiscal Year: 2013
    ..If our study is successful, we can potentially expand use of lytics to a stroke patient population for whom little acute intervention is currently offered. ..
  46. Sleep apnea health disparities in Mexican American stroke patients
    Lynda D Lisabeth; Fiscal Year: 2013
    ..It will also allow for the rigorous study of ethnic comparisons of sleep apnea after stroke in European Americans and Hispanics, the largest minority in the United States. ..
  47. A Novel Ultrasound Phased Array and Sonication Method for Stroke Treatments
    Kullervo Hynynen; Fiscal Year: 2012
    ..During this research we plan to develop such a system and perform all of the experiments needed prior to starting clinical trials. This research may have a major impact on patient care. ..
  48. Miami Regional Coordinating Center for NINDS Stroke Trials Network
    Jose G Romano; Fiscal Year: 2013
    ..Therefore, we have the depth and breadth of expertise and resources to successfully function as a RCC in the Stroke Trials Network. ..
  49. Protective mechanisms of ischemic postconditioning
    Heng Zhao; Fiscal Year: 2013
    ..Specific Aim 3. To examine the protective effects of the Akt/PRAS40 pathway on the pro-inflammatory response of HMGB1 and Cox-2, and the galectin-9/Tim-3 inflammatory pathway. ..
  50. Donepezil to promote functional recovery post-stroke
    Ellen M Whyte; Fiscal Year: 2013
    ..This study holds promise to identify a pharmacologic intervention, which when combined with rehabilitation, would be a simple and widely generalizable strategy to promote post-stroke functional recovery. ..
  51. Stroke Imaging of Conscious Rats
    Timothy Q Duong; Fiscal Year: 2013
    ..These findings have the potential to positively impact stroke research, including testing of novel therapeutic strategies, as well as enhance clinical decision making in the treatment of acute stroke. ..
  52. MMPs contribute to hyperthermia-enhanced vascular injury
    Chen Xu Wang; Fiscal Year: 2011
    ..Therefore, the information obtained from the proposed studies should benefit the development of new therapeutic strategies and improve the clinical management of stroke patients. ..
  53. Therapeutic Window for Acute Stroke Therapy (P50)
    Brett C Meyer; Fiscal Year: 2012
    ..abstract_text> ..
  54. An Observational Acute Stroke Model for Decision Support and Comparing Outcomes
    Gary Duckwiler; Fiscal Year: 2013
    ..The ultimate result of this effort will be a set of informatics-driven modeling tools and a database for acute stroke treatment. ..
  55. Impact of Regionalization of Care in Acute Stroke Patients
    Prasanthi Govindarajan; Fiscal Year: 2013
    ..By providing evidence for patient outcomes in a regionalized stroke system.our research will provide scientific knowledge to promote health policy changes of great public health importance at a national level. ..
  56. Center for Stroke Disaparities Solution
    Olajide Williams; Fiscal Year: 2013
  57. Who Benefits from tPA 3-6 hours after Stroke
    Maarten G Lansberg; Fiscal Year: 2010
    ..They will provide guidance throughout the award period and facilitate his transition into a successful independent investigator. ..
  58. PRAISE: Preventing recurrence of all inner-city strokes through education;
    Carol R Horowitz; Fiscal Year: 2011
    ..Finally, if the trial is successful, we will work to sustain the program locally, disseminate the results nationally, and use the lessons learned to inform health policy. ..
  59. Reducing Brain Injury After Focal Ischemia Using a Nitric Oxide-Neutral Oxygen Ca
    STEPHEN CARY; Fiscal Year: 2012
    ..amp;'#(%)*+ ",-./01+%-23+4+5677+ #"(+$"8+&%9(8%:;(%"#+ ..
  60. Arterial Spin Labeled Perfusion MRI in Acute Ischemic Stroke
    DANNY JIONG JIONG WANG; Fiscal Year: 2013
    ..It is a translational project with the goal to develop and validate an entirely noninvasive and quantitative MRI method for routine clinical evaluation of AIS as well as other cerebrovascular disorders. ..
  61. Ambient Particles and Ischemic and Hemorrhagic Stroke
    Murray A Mittleman; Fiscal Year: 2010
    ..In this study, we will evaluate 16,000 patients with stroke to evaluate the effect of air pollution as a potential trigger of stroke onset. ..
  62. Thrombolysis and Acute Stroke Treatment (TAST) 2011: Forward to Acute Stroke Tre
    Gregory J del Zoppo; Fiscal Year: 2011
    ..1 ..
  63. Translation of pH-weighted MRI to Image Human Acute Stroke
    ALMA SORENSEN; Fiscal Year: 2009
    ..We propose to translate and evaluate the recently developed pH weighted MRI as a new imaging marker for human ischemic tissue, which has potential to improve the diagnostic value of MRI and assist with image-guided stroke therapy. ..
  64. Novel Biomarkers for Stroke Injury
    MONIKA OLI; Fiscal Year: 2005
    ..In addition, both the SBDP150 and SBDP120 ELISA will be validated in CSF and serum in a rodent model of stroke injury (MCAO injury). (Months 4-6) ..
    Edward H Herskovits; Fiscal Year: 2010
    ..We expect that, as we implement more components of this software suite, neuroscientists will find it much easier to perform complex multivariate analyses of their data relating structure and function of the human brain. ..
    Chelsea Kidwell; Fiscal Year: 2003
    ..abstract_text> ..
  67. Profiling Plasma Unbound Free Fatty Acids for Early Detection of Stroke
    ALAN MARC KLEINFELD; Fiscal Year: 2010
    ..The use of this test would potentially reduce neurological damage from ischemic stroke by reducing the time required to diagnose and treat stroke patients. ..
    Keith Thulborn; Fiscal Year: 2003
    ..abstract_text> ..
    Keith Thulborn; Fiscal Year: 2002
    ..abstract_text> ..
  70. rLOAD: Loading of Aspirin and Clopidogrel in Rabbit Model of Ischemic Stroke
    Dawn Meyer; Fiscal Year: 2009
    ..This animal model research will translate into the support of a new stroke therapy that will limit brain injury, extend healthy life, and reduce disability from ischemic stroke. ..
  71. Older Adults and Specialty Care Use in Managed Care
    Maureen Smith; Fiscal Year: 2002
    ..The proposed research will provide valuable information to clinicians, policymakers and researchers interested in the effects of managed care and health care providers (i.e., hospitals) on acutely-ill older patients. ..
    Stephen Oppenheimer; Fiscal Year: 1999
    ..Control groups for comparison will include TIA patients and age-matched normal individuals. Accomplishment of these aims should indicate prevention strategies for the most common cause of post-stroke death. ..