cerebral hemorrhage

Summary

Summary: Bleeding into a cerebral hemisphere of the brain, including lobar, subcortical white matter, and basal ganglia hemorrhages. Commonly associated conditions include HYPERTENSION; INTRACRANIAL ARTERIOSCLEROSIS; INTRACRANIAL ANEURYSM; CRANIOCEREBRAL TRAUMA; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; CEREBRAL AMYLOID ANGIOPATHY; and CEREBRAL INFARCTION.

Top Publications

  1. ncbi Mechanisms of brain injury after intracerebral haemorrhage
    Guohua Xi
    Department of Neurosurgery, University of Michigan, E Medical Centre Drive, Ann Arbor, MI 48109 0338, USA
    Lancet Neurol 5:53-63. 2006
  2. pmc Cerebral microbleeds: a guide to detection and interpretation
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet Neurol 8:165-74. 2009
  3. ncbi Inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Cereb Blood Flow Metab 27:894-908. 2007
  4. ncbi Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study
    M M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 78:326-33. 2012
  5. pmc Intracerebral haemorrhage
    Adnan I Qureshi
    Zeenat Qureshi Stroke Research Center, Department of Neurology and Neurosurgery, University of Minnesota, MN, Minnesota 55455, USA
    Lancet 373:1632-44. 2009
  6. ncbi Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations
    Alida A Gouw
    VU University Medical Centre, Department of Neurology, De Boelelaan 1117, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:126-35. 2011
  7. pmc Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage
    Lauren H Sansing
    Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Ann Neurol 70:646-56. 2011
  8. ncbi Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
    E Levy
    Department of Pathology, New York University Medical Center, NY 10016
    Science 248:1124-6. 1990
  9. ncbi Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study
    M W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Neurology 70:1208-14. 2008
  10. ncbi Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly
    Douglas B Gould
    Howard Hughes Medical Institute, Bar Harbor, ME 04609, USA
    Science 308:1167-71. 2005

Research Grants

Detail Information

Publications298 found, 100 shown here

  1. ncbi Mechanisms of brain injury after intracerebral haemorrhage
    Guohua Xi
    Department of Neurosurgery, University of Michigan, E Medical Centre Drive, Ann Arbor, MI 48109 0338, USA
    Lancet Neurol 5:53-63. 2006
    ..This review addresses our current understanding of the mechanisms underlying ICH-induced brain injury...
  2. pmc Cerebral microbleeds: a guide to detection and interpretation
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet Neurol 8:165-74. 2009
    ..We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease...
  3. ncbi Inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Cereb Blood Flow Metab 27:894-908. 2007
    ..In the near future, additional strategies that target inflammation could offer exciting new promise in the therapeutic approach to ICH...
  4. ncbi Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study
    M M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 78:326-33. 2012
    ..Cerebral microbleeds are frequently found in the general elderly population and may reflect underlying vascular disease, but their role in cognitive function is unknown...
  5. pmc Intracerebral haemorrhage
    Adnan I Qureshi
    Zeenat Qureshi Stroke Research Center, Department of Neurology and Neurosurgery, University of Minnesota, MN, Minnesota 55455, USA
    Lancet 373:1632-44. 2009
    ..These approaches improve clinical management of patients with intracerebral haemorrhage and promise to reduce mortality and increase functional survival...
  6. ncbi Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations
    Alida A Gouw
    VU University Medical Centre, Department of Neurology, De Boelelaan 1117, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:126-35. 2011
    ..By reviewing studies that directly correlated postmortem MRI and histopathology, this paper aimed to characterise the pathological substrates of SVD in order to create more understanding as to its heterogeneous clinical manifestation...
  7. pmc Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage
    Lauren H Sansing
    Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Ann Neurol 70:646-56. 2011
    ..This study aimed to determine the role of Toll-like receptor 4 (TLR4) in the innate immune response after ICH and its impact on neurobehavioral outcome...
  8. ncbi Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
    E Levy
    Department of Pathology, New York University Medical Center, NY 10016
    Science 248:1124-6. 1990
    An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with ..
  9. ncbi Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study
    M W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Neurology 70:1208-14. 2008
    ..We investigated the prevalence of and risk factors for microbleeds in the general population aged 60 years and older...
  10. ncbi Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly
    Douglas B Gould
    Howard Hughes Medical Institute, Bar Harbor, ME 04609, USA
    Science 308:1167-71. 2005
    ..Half of the mutant mice died with cerebral hemorrhage within a day of birth, and approximately 18% of survivors had porencephaly...
  11. ncbi Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis
    Charlotte Jj van Asch
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet Neurol 9:167-76. 2010
    ..We aimed to assess the incidence, case fatality, and functional outcome of intracerebral haemorrhage in relation to age, sex, ethnic origin, and time period in studies published since 1980...
  12. ncbi Hematoma resolution as a therapeutic target: the role of microglia/macrophages
    Xiurong Zhao
    Professor of Neurology, Director of Stroke Research, Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Stroke 40:S92-4. 2009
    ..Proxisome proliferator activated receptor-gamma agonists could represent a potential treatment strategy for treatment of ICH...
  13. ncbi Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting
    Charlotte Cordonnier
    Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK
    Brain 130:1988-2003. 2007
    ..We conclude by proposing criteria for ideal study design and reporting...
  14. ncbi Proportion of different subtypes of stroke in China
    Lin feng Zhang
    Department of Epidemiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Li Shi Rd 167, Beijing, 100037, People s Republic of China
    Stroke 34:2091-6. 2003
    ..The goal of this article is to clarify the proportion of stroke subtypes in China, where stoke is the most common cause of death...
  15. ncbi Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
    ..Here, we have used conditional knockout technology to address whether the cerebral hemorrhage is due to primary defects in vascular or neural cell types...
  16. ncbi The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage
    Jonathan Rosand
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Arch Intern Med 164:880-4. 2004
    ..We studied the determinants of ICH outcome to quantify the independent effect of warfarin...
  17. ncbi High-dose atorvastatin after stroke or transient ischemic attack
    Pierre Amarenco
    Denis Diderot University, Paris
    N Engl J Med 355:549-59. 2006
    ..Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established...
  18. ncbi Risk factors for intracerebral hemorrhage in the general population: a systematic review
    M J Ariesen
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
    Stroke 34:2060-5. 2003
    ..Although data on some risk factors for intracerebral hemorrhage (ICH) already are beyond doubt, for other factors, the evidence is less clear. We performed a systematic overview of case-control and cohort studies on risk factors for ICH...
  19. pmc Preclinical and clinical research on inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Traylor Building 809, Baltimore, MD 21205, USA
    Prog Neurobiol 92:463-77. 2010
    ....
  20. pmc MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength
    R N K Nandigam
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 30:338-43. 2009
    ....
  21. ncbi Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study)
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 363:1925-33. 2004
    ..We aimed to obtain these data...
  22. ncbi Molecular signatures of brain injury after intracerebral hemorrhage
    J Castillo
    Department of Neurology, Hospital Clinico Universitario, Santiago de Compostela, Spain
    Neurology 58:624-9. 2002
    ..The mechanisms of cellular death in the tissue surrounding an intracerebral hemorrhage (ICH) are not defined...
  23. ncbi Rapid appearance of new cerebral microbleeds after acute ischemic stroke
    S B Jeon
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, Republic of Korea
    Neurology 73:1638-44. 2009
    ..We hypothesized that MBs may develop rapidly after certain critical events, such as strokes, and investigated the frequency, location, and factors associated with the formation of new MBs after acute ischemic stroke...
  24. ncbi The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population
    Lijun Wu
    First Affiliated Hospital, Medical College of Shantou University, Shantou, China
    Stroke 40:2973-6. 2009
    ..The 1425G/A SNP in PRKCH (rs2230500) is significantly associated with ischemic stroke in Japanese. The aim of the present study is to investigate the associations in ischemic stroke and other types of stroke in the Chinese population...
  25. pmc Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, 720 Rutland Ave, Traylor Bldg 809, Baltimore, MD 21205, USA
    Brain 130:1643-52. 2007
    ..These data reveal a previously unrecognized role of HO-1 in early brain injury after ICH. Thus, modulation of HO-1 signalling should be assessed further in clinical settings, especially for haemorrhagic states...
  26. ncbi The ABCs of measuring intracerebral hemorrhage volumes
    R U Kothari
    Department of Emergency Medicine, University of Cincinnati, Ohio 45267 0769, USA
    Stroke 27:1304-5. 1996
    ..Hemorrhage volume is a powerful predictor of 30-day mortality after spontaneous intracerebral hemorrhage (ICH). We compared a bedside method of measuring CT ICH volume with measurements made by computer-assisted planimetric image analysis...
  27. ncbi The ICH score: a simple, reliable grading scale for intracerebral hemorrhage
    J C Hemphill
    Department of Neurology, University of California, San Francisco, USA
    Stroke 32:891-7. 2001
    ..Despite several existing outcome prediction models for ICH, there is no standard clinical grading scale for ICH analogous to those for traumatic brain injury, subarachnoid hemorrhage, or ischemic stroke...
  28. ncbi Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794 8451, USA
    Neurocrit Care 3:77-85. 2005
    ....
  29. ncbi Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
    Martin C Herzig
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    Nat Neurosci 7:954-60. 2004
    ..In contrast to Alzheimer disease (AD), the brains of those affected by hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) show few parenchymal amyloid plaques...
  30. ncbi Incidence and trends of stroke and its subtypes in China: results from three large cities
    Bin Jiang
    Department of Neuroepidemiology, Beijing Neurosurgical Institute, Beijing 100050, P R China
    Stroke 37:63-8. 2006
    ..To examine the incidence and trends of stroke and its major subtypes during the 1990s in 3 cities in China...
  31. pmc Molecular pathophysiology of cerebral hemorrhage: secondary brain injury
    Jaroslaw Aronowski
    University of Texas HSC, Medical School, Department of Neurology, 6431 Fannin, Rm 7 210, Houston, TX 77030, USA
    Stroke 42:1781-6. 2011
    ....
  32. ncbi Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Ann Neurol 61:352-62. 2007
    ..Promotion of phagocytosis in a timely and efficient manner may limit the toxic effects of persistent blood products on surrounding tissue and may be important for recovery after ICH...
  33. ncbi Neutrophil depletion reduces blood-brain barrier breakdown, axon injury, and inflammation after intracerebral hemorrhage
    Iska Moxon-Emre
    Toronto Western Research Institute, University Health Network, Toronto, Canada
    J Neuropathol Exp Neurol 70:218-35. 2011
    ..These results show that, in experimental ICH, neutrophils produce matrix metalloprotease9and contribute to blood vessel disruption, BBB breakdown, axon damage, and astrocytic and microglial/macrophage responses that evolve after ICH...
  34. ncbi Heme and iron metabolism: role in cerebral hemorrhage
    Kenneth R Wagner
    Departments of Neurology, Pediatrics and Neuroscience Programl, Unviersity of Cincinnati College of Medicine, Cincinnati, Ohio 45220, USA
    J Cereb Blood Flow Metab 23:629-52. 2003
    ..After a cerebral hemorrhage, large numbers of hemoglobin-containing red blood cells are released into the brain's parenchyma and/or ..
  35. ncbi Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Out
    Joseph Broderick
    Stroke 38:2001-23. 2007
    ..The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous intracerebral hemorrhage...
  36. ncbi Early surgical treatment vs conservative management for spontaneous supratentorial intracerebral hematomas: A prospective randomized study
    Georgios Pantazis
    Department of Neurosurgery, Thriassio General Hospital, 19600 Magoula, Athens, Greece
    Surg Neurol 66:492-501; discussion 501-2. 2006
    ..Treatment of primary SICH is still controversial. The aim of this study was to investigate the effectiveness of craniotomy and early hematoma evacuation vs nonoperative management in patients with SICH...
  37. ncbi Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat
    Jason K Wasserman
    Toronto Western Research Institute, University Health Network, Toronto Ontario, Canada M5T 2S8
    Exp Neurol 207:227-37. 2007
    ..Thus, minocycline, administered at a clinically relevant time, appears to target the inflammatory processes involved in edema development after ICH...
  38. ncbi Risk factors for intracerebral hemorrhage in a pooled prospective study
    Jared D Sturgeon
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
    Stroke 38:2718-25. 2007
    ..We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS)...
  39. ncbi Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications
    Hans Christian Koennecke
    Department of Neurology, Evangelisches Krankenhaus Konigin Elisabeth Herzberge, Berlin, Germany
    Neurology 66:165-71. 2006
    ..To assess the potential role of cerebral microbleeds (CMB) in intracerebral hemorrhage (ICH), as indicators of cerebral small-vessel disease, and their possible implications for antithrombotic treatment...
  40. ncbi Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation
    Ya Hua
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    Neurosurgery 58:542-50; discussion 542-50. 2006
    ....
  41. ncbi Clinical significance of acute phase reaction in stroke patients
    Tomasz Dziedzic
    Department of Neurology, Jagiellonian University, Krakow, Poland
    Front Biosci 13:2922-7. 2008
    ..Plasma IL-6 is independently associated with hematoma enlargement and fibrinogen level predicts early neurological deterioration and outcome in patients with intracerebral hemorrhage...
  42. ncbi MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke
    Anna Rosell
    Neurovascular Research Laboratory, Neurovascular Unit, Department of Neurology, Universitat Autonoma de Barcelona, Institut de Recerca, Hospital Vall d Hebron, Barcelona, Spain
    Stroke 39:1121-6. 2008
    ..Our aim was to investigate MMP-2 and MMP-9 in the ischemic brain and its relation with blood-brain barrier breakdown after hemorrhagic transformation in human stroke...
  43. ncbi Complications of intracerebral haemorrhage
    Joyce S Balami
    Acute Stroke Programme, Department of Medicine and Clinical Geratology, Oxford University Hospitals NHS Trust, Oxford, UK
    Lancet Neurol 11:101-18. 2012
    ..Further studies are needed to enhance the evidence-based recommendations for the management of this important clinical problem...
  44. pmc European research priorities for intracerebral haemorrhage
    Thorsten Steiner
    Division of Clinical Neurosciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
    Cerebrovasc Dis 32:409-19. 2011
    ....
  45. ncbi Blood pressure and total cholesterol level are critical risks especially for hemorrhagic stroke in Akita, Japan
    Kazuo Suzuki
    Department of Epidemiology, Research Institute for Brain and Blood Vessels Akita, Akita Kumiai General Hospital, Akita, Japan
    Cerebrovasc Dis 31:100-6. 2011
    ..Stroke risk factors differ depending on the subtype of stroke; moreover, the distribution of risks is different among countries and races...
  46. ncbi An effective treatment for cerebral hemorrhage: minimally invasive craniopuncture combined with urokinase infusion therapy
    Haixin Sun
    Department of Neuroepidemiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
    Neurol Res 32:371-7. 2010
    ....
  47. pmc Digitally quantifying cerebral hemorrhage using Photoshop and Image J
    Xian Nan Tang
    Department of Neurology, University of California, San Francisco and SF VAMC, San Francisco, CA 94121, USA
    J Neurosci Methods 190:240-3. 2010
    ..94). We conclude that our method can accurately quantify the extent of hemorrhage. An advantage of this technique is that brain tissue can be used for additional studies...
  48. ncbi Relative importance of proteinase-activated receptor-1 versus matrix metalloproteinases in intracerebral hemorrhage-mediated neurotoxicity in mice
    Mengzhou Xue
    Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive, Calgary, Alberta T2N 4N1, Canada
    Stroke 40:2199-204. 2009
    ..In this study, we have investigated the relative roles of proteinase activated receptor-1, a thrombin receptor, and MMPs in brain injury induced by thrombin or blood...
  49. ncbi Microglial activation and brain injury after intracerebral hemorrhage
    J Wu
    Medical School, Zhejiang University, Hangzhou, China
    Acta Neurochir Suppl 105:59-65. 2008
    ..1 +/- 0.7% vs. 82.7 +/- 1.3% in vehicle-treated group; p < 0.05) after ICH. These results suggest a critical role of microglia activation in ICH-related brain injury...
  50. ncbi Modeling intracerebral hemorrhage: glutamate, nuclear factor-kappa B signaling and cytokines
    Kenneth R Wagner
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Stroke 38:753-8. 2007
    ..We also briefly review the surgical treatment for intracerebral hemorrhage and list the pharmacological treatment studies that have recently appeared...
  51. ncbi High-mobility group box1 protein promotes neuroinflammation after intracerebral hemorrhage in rats
    C Lei
    Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, PR China
    Neuroscience 228:190-9. 2013
    ..These findings suggest that HMGB1 may act as an early proinflammatory cytokine within the neurovascular unit to mediate inflammation during the acute phase of ICH...
  52. ncbi Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 358:2127-37. 2008
    ..We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes...
  53. pmc Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study
    Seung Hoon Lee
    Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea
    PLoS ONE 6:e25930. 2011
    ..Cerebral microbleeds (MBs) are understood as an important radiologic marker of intracerebral hemorrhage. We sought to investigate the temporal changes of MBs and clinical factors associated with the changes using long-term follow-up MRI...
  54. ncbi Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products
    Feng ping Huang
    Department of Neurosurgery, University of Michigan, Ann Arbor 48109 0532, USA
    J Neurosurg 96:287-93. 2002
    ..The authors have found that red blood cell lysis plays an important role in edema development after ICH. In the present study, they sought to determine whether degradation products of hemoglobin cause brain edema...
  55. ncbi Three-year survival and stroke recurrence rates in patients with primary intracerebral hemorrhage
    Elisabet Zia
    Cardiovasular Epidemiology Research Group, Department of Neurology, A, Malmo University Hospital, Institution of Clinical Sciences in Malmö, University of Lund, Lund, Sweden
    Stroke 40:3567-73. 2009
    ..Our aim was to evaluate mortality and stroke recurrence rates in relation to hemorrhage characteristics, demographic and clinical factors, in a large unselected patient cohort...
  56. ncbi Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome
    V De Herdt
    Universite Lille Nord de France, Neurology Department, Lille, France
    Neurology 77:1794-800. 2011
    ..Therefore, we aimed to identify incidence, associated factors, and influence on outcome of ES in patients with ICH...
  57. ncbi c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage
    Delphine Michel-Monigadon
    Department of Clinical Neuroscience, Neurology Service, Centre Hospitalier Universitaire Vaudois and Lausanne University, Lausanne, Switzerland
    Cerebrovasc Dis 29:564-70. 2010
    ..We investigated the effect of JNK inhibition in intracerebral hemorrhage (ICH)...
  58. ncbi Early care limitations independently predict mortality after intracerebral hemorrhage
    D B Zahuranec
    Stroke Program, University of Michigan Medical School, Ann Arbor, MI 48109 0316, USA
    Neurology 68:1651-7. 2007
    ..Intracerebral hemorrhage (ICH) is associated with a high early mortality rate. We examined the impact of early do not resuscitate (DNR) orders and other limitations in aggressive care on mortality after ICH in a community-based study...
  59. ncbi The development of an improved preclinical mouse model of intracerebral hemorrhage using double infusion of autologous whole blood
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res 1222:214-21. 2008
    ....
  60. ncbi Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema
    Marie France Penet
    Centre de Resonance Magnetique Biologique et Medicale, Unite Mixte de Recherche Centre National de la Recherche Scientifique 6612, 13005 Marseille, France
    J Neurosci 25:7352-8. 2005
    ..They improve our understanding of the pathogenesis of cerebral malaria and may provide the necessary noninvasive surrogate markers for quantitative monitoring of treatment...
  61. pmc Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke
    Maarten G Lansberg
    Stanford University, Stanford Stroke Center, Palo Alto, California 94304, USA
    Stroke 38:2275-8. 2007
    ..MRI-based variables have generally not been included in predictive models, and little is known about the influence of reperfusion on SICH risk...
  62. ncbi Density and shape as CT predictors of intracerebral hemorrhage growth
    Christen D Barras
    Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Stroke 40:1325-31. 2009
    ..We hypothesized that irregular hematoma shape and density heterogeneity, reflecting active, multifocal bleeding or a variable bleeding time course, would predict ICH growth...
  63. ncbi Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats
    Jason K Wasserman
    Toronto Western Research Institute, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada
    Eur J Neurosci 28:1316-28. 2008
    ..These findings have important implications for efforts to reduce secondary injury after ICH and to develop anti-inflammatory therapies to treat ICH in aged humans...
  64. ncbi Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles
    R Natte
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Ann Neurol 50:765-72. 2001
    ..the amount of cerebral amyloid angiopathy and the presence of dementia in 19 patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type...
  65. ncbi Treatment of acute hypertension in patients with intracerebral hemorrhage using American Heart Association guidelines
    Adnan I Qureshi
    Clinical Trials Division, Zeenat Qureshi Stroke Research Center, Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Crit Care Med 34:1975-80. 2006
    ....
  66. ncbi Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI
    David J Werring
    Stroke Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 127:2265-75. 2004
    ..These findings have implications for the diagnosis of stroke patients with cognitive impairment, and for the appropriate use of antihypertensive and antiplatelet treatments in these patients...
  67. ncbi Experimental intracerebral hemorrhage in the mouse: histological, behavioral, and hemodynamic characterization of a double-injection model
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, FL 33101, USA
    Stroke 34:2221-7. 2003
    ..We investigated the effect of intrastriatal injection of blood or cerebrospinal fluid (CSF) on cerebral blood flow (CBF), neurological score, hematoma volume, and brain swelling...
  68. ncbi Evidence for an association between air pollution and daily stroke admissions in Kaohsiung, Taiwan
    Shang Shyue Tsai
    Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Stroke 34:2612-6. 2003
    ..This study was undertaken to determine whether there is an association between air pollution and hospital admissions for stroke in Kaohsiung, Taiwan...
  69. ncbi Triggers and mediators of hemorrhagic transformation in cerebral ischemia
    Xiaoying Wang
    Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Boston, MA
    Mol Neurobiol 28:229-44. 2003
    ..Further investigations into the molecular mediators of hemorrhagic transformation may reveal new therapeutic targets for this clinically complex problem...
  70. pmc Blood pressure, haemorrhagic stroke, and ischaemic stroke: the Korean national prospective occupational cohort study
    Yun Mi Song
    Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul, Korea
    BMJ 328:324-5. 2004
  71. ncbi Incidence of cerebral hemorrhage in the Changsha community. A prospective study from 1986 to 2000
    Qi Dong Yang
    Department of Neuroepidemiology, Institute of Neurology, The Xiangya Hospital, Central South University, Changsha, People s Republic of China
    Cerebrovasc Dis 17:303-13. 2004
    ..Republic of China, not only had a high incidence of stroke, but also had almost the highest incidence of cerebral hemorrhage. To provide information for preventing and managing ICH, we undertook this study supervising and ..
  72. ncbi Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry
    Simona Sacco
    Department of Neurology, University of L Aquila, L Aquila, Italy
    Stroke 40:394-9. 2009
    ..The purpose of this study was to evaluate the incidence and prognosis of intracerebral hemorrhage...
  73. ncbi External validation of the ICH score
    Jennifer L Clarke
    Department of Neurology, University of California, San Francisco, and San Francisco General Hospital, CA 94110, USA
    Neurocrit Care 1:53-60. 2004
    ..The purpose of this study was to determine whether the ICH score accurately risk-stratifies patients in an independent cohort...
  74. pmc Development and validation of the Essen Intracerebral Haemorrhage Score
    C Weimar
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    J Neurol Neurosurg Psychiatry 77:601-5. 2006
    ..Nevertheless, outcome is favourable in about 30% of patients. Only one model for the prediction of favourable outcome has been validated so far...
  75. ncbi Silent microbleeds are associated with volume of primary intracerebral hemorrhage
    Seung Hoon Lee
    Department of Neurology, Neuroscience Research Institute, SNUMRC, Seoul National University Hospital, Seoul, Republic of Korea
    Neurology 66:430-2. 2006
    ..Moreover, the presence of microbleeds was an independent risk factor for large-sized hemorrhage. These data show that microbleeds may be associated with a larger ICH volume...
  76. pmc Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study
    Werner Hacke
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Lancet Neurol 8:141-50. 2009
    ....
  77. ncbi Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage
    Sonia Abilleira
    Neurovascular Unit, Department of Neurology, Hospital General Vail d Hebron, Barcelona, Spain
    J Neurosurg 99:65-70. 2003
    ..The authors investigated the MMP-9 concentration in patients after acute intracerebral hemorrhage (ICH) and its relation to perihematomal edema (PHE)...
  78. ncbi Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage
    Emiri Tejima
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, USA
    J Cereb Blood Flow Metab 27:460-8. 2007
    ....
  79. pmc Minocycline reduces intracerebral hemorrhage-induced brain injury
    Jimin Wu
    Medical School, Zhejiang University, Hangzhou, China Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neurol Res 31:183-8. 2009
    ..The present study investigated if thrombin stimulates tumor necrosis factor-alpha and interleukin-1beta secretion in vitro and if microglial inhibition reduces intracerebral hemorrhage-induced brain injury in vivo...
  80. ncbi Ethnic disparities in incidence of stroke subtypes: Auckland Regional Community Stroke Study, 2002-2003
    Valery Feigin
    Clinical Trials Research Unit, Department of Medicine and School of Population Health, Faculty of Medicine and Health Sciences, University of Auckland, New Zealand
    Lancet Neurol 5:130-9. 2006
    ..We aimed to provide such data within the large multi-ethnic population of Auckland, New Zealand...
  81. ncbi Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study
    Adnan I Qureshi
    Department of Neurosurgery, Toshiba Stroke Research Center, University of Buffalo, State University of New York, USA
    Crit Care Med 31:1482-9. 2003
    ....
  82. pmc Neuroprotective role of haptoglobin after intracerebral hemorrhage
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Health Science Center, Medical School at Houston, Houston, Texas 77030, USA
    J Neurosci 29:15819-27. 2009
    ..We conclude that Hp, particularly the brain-derived Hp, plays cytoprotective roles and represents a potential therapeutic target for ICH treatment...
  83. ncbi Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats
    Toshihisa Sumii
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
    Stroke 33:831-6. 2002
    ..In this study we used a previously established quantitative rat model of tPA-associated hemorrhage to test the hypothesis that matrix metalloproteinases (MMPs) are involved...
  84. ncbi Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage
    S M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    Neurology 66:1175-81. 2006
    ..Although volume of intracerebral hemorrhage (ICH) is a predictor of mortality, it is unknown whether subsequent hematoma growth further increases the risk of death or poor functional outcome...
  85. ncbi Sex differences in US mortality rates for stroke and stroke subtypes by race/ethnicity and age, 1995-1998
    Carma Ayala
    Cardiovascular Health Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Stroke 33:1197-201. 2002
    ..Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/ethnicity...
  86. ncbi The role of endogenous versus exogenous tPA on edema formation in murine ICH
    Ruth Thiex
    Department of Neurosurgery, Aachen University, Aachen, Germany
    Exp Neurol 189:25-32. 2004
    ..In conclusion, the role of the endogenous tPA appears to be limited to the early phase of edema formation, whereas exogenous rtPA is edema-promoting between days 3 and 7 after ICH...
  87. ncbi Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT)
    Takenori Yamaguchi
    National Cardiovascular Center, Suita, Osaka, Japan
    Stroke 37:1810-5. 2006
    ..6 mg/kg, which is lower than the internationally approved dosage of 0.9 mg/kg, aiming to assess the efficacy and safety of alteplase in acute ischemic stroke for the Japanese...
  88. ncbi Brain microbleeds and Alzheimer's disease: innocent observation or key player?
    Charlotte Cordonnier
    Univ Lille Nord de France, CHU Lille, EA 1046 Pôle de neurologie F 59000 Lille, France
    Brain 134:335-44. 2011
    ..We also review the available evidence and highlight the pitfalls of our current knowledge on brain microbleeds in the setting of clinical trials design...
  89. pmc Microbleeds versus macrobleeds: evidence for distinct entities
    Steven M Greenberg
    MGH Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2382-6. 2009
    ..It is unclear whether microbleeds and macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies...
  90. ncbi HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats
    Masatoshi Ohnishi
    Department of Pharmacotherapeutics, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima, Japan
    Neuropharmacology 61:975-80. 2011
    ..Moreover, glycyrrhizin partially but significantly ameliorated ICH-induced neuron loss inside hematoma. These findings suggest that an HMGB1 inhibitor glycyrrhizin is a potential candidate for a remedy for ICH...
  91. pmc Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins
    Joseph H McCarty
    Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 22:7667-77. 2002
    ..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
  92. ncbi Treatment of intracerebral haemorrhage
    Stephan A Mayer
    Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology Columbia University, New York, NY 10032, USA
    Lancet Neurol 4:662-72. 2005
    ....
  93. ncbi Hemorrhagic and ischemic strokes compared: stroke severity, mortality, and risk factors
    Klaus Kaae Andersen
    Informatics and Mathematical Modelling, Section for Statistics, Technical University of Denmark, Lyngby, Denmark
    Stroke 40:2068-72. 2009
    ..Stroke patients with hemorrhagic (HS) and ischemic strokes were compared with regard to stroke severity, mortality, and cardiovascular risk factors...
  94. ncbi White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome
    J M Perlman
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas 75235 9063, USA
    Early Hum Dev 53:99-120. 1998
    ..A clearer understanding of pathogenesis of both conditions is essential so as to provide targeted preventative strategies...
  95. ncbi Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794 8651, USA
    Stroke 36:613-8. 2005
    ..In this study, we investigate the protection and efficacy of treatment when MIF is administered 2 hours after collagenase injection...
  96. ncbi Prediction of death in patients with primary intracerebral hemorrhage: a prospective study of a defined population
    Ola G Nilsson
    Department of Neurosurgery, Lund University Hospital, Sweden
    J Neurosurg 97:531-6. 2002
    ..Predictors of early (30-day) and long-term (1-year) mortality rates after primary intracerebral hemorrhage (ICH) were studied in a large population in southern Sweden...
  97. ncbi Grading scale for prediction of outcome in primary intracerebral hemorrhages
    José L Ruiz-Sandoval
    Department of Neurology and Neurosurgery, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico
    Stroke 38:1641-4. 2007
    ..This study aimed to independently derive an intracerebral hemorrhage grading scale (ICH-GS) for prediction of 3 outcome measures...
  98. ncbi Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study
    Daniel Woo
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    Stroke 33:1190-5. 2002
    ..We report a preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of ICH...
  99. ncbi Aspirin and risk of hemorrhagic stroke: a meta-analysis of randomized controlled trials
    J He
    Department of Biostatistics and Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    JAMA 280:1930-5. 1998
    ..Aspirin has been widely used to prevent myocardial infarction and ischemic stroke but some studies have suggested it increases risk of hemorrhagic stroke...
  100. ncbi Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:1415-20. 2004
    ..We sought to determine whether hemorrhages detected at the time of lobar ICH predict the major clinical complications of CAA: recurrent ICH or decline in cognition and function...
  101. ncbi Acute inflammatory reaction following experimental intracerebral hemorrhage in rat
    C Gong
    Department of Neurosurgery, University of Michigan, R5605 Kresge I, P O Box 0532, 1500 East Medical Center Drive, 48109 0532, Ann Arbor, MI, USA
    Brain Res 871:57-65. 2000
    ..We hypothesized that inflammatory mediators released from the blood after cerebral hemorrhage might cause secondary brain injury and edema formation...

Research Grants62

  1. Regulation of neural cell volume by thrombin receptors
    Tooba Cheema; Fiscal Year: 2006
    ..that activation of thrombin receptors in the brain can exert a neuroprotective role against ischemia or cerebral hemorrhage has recently emerged...
  2. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..kidneys, liver and other vital organs and, if undetected or untreated, can lead to seizures (eclampsia), cerebral hemorrhage, failure in vital organs (i.e., kidney and heart) and death...
  3. Ac-SDKP for Treatment of Acute Stroke
    Zheng Gang Zhang; Fiscal Year: 2013
    ..5h). The most feared complication after tPA treatment of stroke is an increased risk of cerebral hemorrhage. Our preliminary data indicate that N-acetyl- seryl-aspartyl-lysyl-proline (Ac-SDKP), a peptide normally ..
  4. VEGF regulation of neurogenesis
    DIANE CATHERINE DARLAND; Fiscal Year: 2011
    ..processes in development, but also play key roles in response to injury and pathological stressors, such as cerebral hemorrhage and stroke...
  5. Role of MicroRNAs in the Mechanisms of Drug Dependence
    Paul J Kenny; Fiscal Year: 2012
    ..is associated with potentially fatal cardiovascular events such as arrhythmias, myocardial infarction, and cerebral hemorrhage, and results in approximately $580 million in direct healthcare costs...
  6. Testing of Innate Immunity Stimulation via TLR9 on CAA using Non-human Primates.
    Henrieta Scholtzova; Fiscal Year: 2013
    ..CAA is an age-related disorder of the brain vasculature that causes 20% of non-traumatic cerebral hemorrhage in humans. Solving the problem of CAA is becoming a priority for ensuring the success of immunotherapy...
  7. Imaging Study of Combination Thrombolytic Therapy
    GEORGE JEROME SHAW; Fiscal Year: 2010
    ..There are many contraindications and side effects to this treatment including intra-cerebral hemorrhage (ICH)...
  8. Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-II)
    ADNAN IQBAL QURESHI; Fiscal Year: 2013
    ..The high rates of death and disability, and high financial costs connected with this illness demand that new evidenced-based treatments be developed. ..
  9. Plasminogen Activation &SK: Structure-Function
    Guy L Reed; Fiscal Year: 2012
    ..tenet of the fibrinolytic field by determining whether fibrin-specific Pg activation decreases the risk of cerebral hemorrhage in vivo...
  10. ABetaPP Influences Cerebral Thrombosis
    William E Van Nostrand; Fiscal Year: 2013
    ..limits the extent of thrombosis associated with in vivo models of carotid artery thrombosis, cerebral hemorrhage, and focal cerebral ischemia...
  11. SCORE-IT: The CTA Spot Sign Score in Acute Cerebral Hemorrhage
    Jonathan Rosand; Fiscal Year: 2013
    ..Partnering with the Antihypertensive Treatment in Acute Cerebral Hemorrhage-2 (ATACH-2) trial, we will determine whether CTA and MRI can identify patients at high risk for hematoma ..
  12. Mechanisms regulating vessel development in the embryonic and postnatal brain
    Zhen Huang; Fiscal Year: 2013
    ..data show that ablation of neural progenitors from the embryonic cortex results in vessel regression and cerebral hemorrhage. We also find that ablation of glia from the early postnatal brain disrupts vessel network elaboration and ..
  13. Combination Treatment of tPA and Apyrase for Stroke
    Ridong Chen; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: We will utilize clinically relevant embolic stroke models in rats to validate whether human apyrase improves efficacy and reduce cerebral hemorrhage associated with thrombolytic treatment of ischemic stroke.
  14. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
    A complication of stroke is cerebral hemorrhage. The heme oxygenase (HO) system, which plays a key role in cellular defense mechanisms, catalyses oxidation of hemoglobin heme to biologically active molecules: bile pigments and CO...
  15. A platelet ligand mimetic for neurothrombotic disorders
    Catherine Woods; Fiscal Year: 2006
    ..There is an urgent medical need for improved therapies for diseases such as stroke, cerebral hemorrhage and cerebral thrombotic complications in disorders such as thrombotic thrombocytopenic purpura (TTP), ..
  16. MR IMAGING OF HEMORRHAGE
    Keith Thulborn; Fiscal Year: 1992
    A prominent feature of clinical MR images of cerebral and extra-cerebral hemorrhage, regardless of etiology, are regions of altered signal intensity attributed to paramagnetic effects of iron from extravasated erythrocytes...
  17. RAPID DETOXIFICATION OF COCAINE BY BUTYRYLCHOLINESTERASE
    Oksana Lockridge; Fiscal Year: 2000
    DESCRIPTION (Applicant's Abstract): Cocaine has toxic effects on the brain and heart causing seizures, cerebral hemorrhage, a marked increased in heart rate, disturbance of heart rhythm, and hypertensive crisis...
  18. THROMBOSTATIN--A SELECTIVE ANTITHROMBIN
    Alvin Schmaier; Fiscal Year: 1999
    ..g. hirudin and hirulog, are associated with increased cerebral hemorrhage. This project will create a new class of selective a-thrombin inhibitors...
  19. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): Cerebral hemorrhage is the main cause of abnormal cerebral arteriolar constriction resulting in cerebral ischemia that leads to paralysis, mental and physical disabilities, and deaths...
  20. ROLES OF VASCULAR AMYLOID BETA PROTEIN PRECURSOR
    William Van Nostrand; Fiscal Year: 1999
    ..hemorrhaging in patients with a rare disorder that is related to Alzheimer's disease known as hereditary cerebral hemorrhage with amyloidosis-Dutch type...
  21. tPA plus MMP inhibition for combination stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..for ischemic stroke is the limited time window for effective therapy and the related complications of cerebral hemorrhage and edema...
  22. Antihypertensive Treatment in Acute Cerebral Hemorrhage
    Adnan Qureshi; Fiscal Year: 2006
    ..The 3 month functional outcome measured by modified Rankin Scale and Barthel Index will be used to obtain a preliminary estimate of the treatment effect related to the anti-HTN therapy. Time line: Three years. [unreadable] [unreadable]..
  23. AbetaPP and Cerebral Vasculopathy
    William Van Nostrand; Fiscal Year: 2006
    ..feature of patients with Alzheimer's disease (AD) and related disorders and is a primary cause of cerebral hemorrhage. The reason as to why cerebrovascular AB deposition leads to loss of vessel wall integrity and hemorrhagic ..
  24. INHIBITION OF AMYLOID FORMATION BY TRANSTHYRETIN & APOE
    Dmitry Goldgaber; Fiscal Year: 1999
    ..found in the brains and cerebrovasculature of patients with Alzheimer disease, Down Syndrome, hereditary cerebral hemorrhage and in normal aging...
  25. SPECTROSCOPIC DYE BASED LOCALIZATION OF LYMPH NODES
    David Benaron; Fiscal Year: 1999
    ..The core technology has been validated in animals to guide needles to target sites, and in humans to detect cerebral hemorrhage through the intact skull...
  26. MOLECULAR BASIS OF PLASMINOGEN-STREPTOKINASE INTERACTION
    Xuejun Zhang; Fiscal Year: 2005
    ..critical roles in cell migration related to tumor growth and metastasis, Alzheimer's disease and related cerebral hemorrhage and some pathogenic invasions...
  27. Environmental Toxicants in Fetal Basis of Adult-onset Stroke
    VICTORIA HERRERA; Fiscal Year: 2007
    ..Pb-levels, and our preliminary data validating two rat models of fetal basis of adult-onset stroke (cerebral hemorrhage subtype) FeBAD(STROKE), our research proposal aims to test the hypothesis that fetal subtoxic-Pb exposure ..
  28. BETA AND ITS PRECURSOR INFLUENCE HEMOSTATIC ENZYMES
    William Van Nostrand; Fiscal Year: 2001
    ..ABeta) deposition is a hallmark of Alzheimer's disease (AD) and related disorders including hereditary cerebral hemorrhage with amyloidosis Dutch-type (HCHWA-D)...
  29. Transgenic Model for Cerebral Amyloid Angiopathy
    William Van Nostrand; Fiscal Year: 2006
    ..a common pathological feature of patients with Alzheimer's disease (AD) and several related hereditary cerebral hemorrhage with amyloidosis (HCHWA) disorders...
  30. AGING BRAIN--CEREBROVASCULAR MECHANISM & AMYLOID BETA
    Berislav Zlokovic; Fiscal Year: 2003
    ..g., Alzheimer's Disease and related amyloid-beta-peptide (Abeta) disorders, such as hereditary cerebral hemorrhage with amyloidosis Dutch type), Abeta-related vascular injury, brain damage and stroke...
  31. Cancer Detection using Diffuse Luminescence Imaging
    Richard Myers; Fiscal Year: 2009
    ..Other applications could include brain imaging to monitor cerebral function or cerebral hemorrhage, and monitoring tissue and muscle oxygenation, histotoxicity, etc.
  32. INTEGRATIVE PATHOPHYSIOLOGY OF CEREBRAL AVMS
    William Young; Fiscal Year: 2003
    ..Aim II addresses the association of cerebral hemodynamics with the occurrence of spontaneous intra cerebral hemorrhage during the natural course of the disease and is primarily funded by NS34949...
  33. TRANSOMIC MOUSE MODEL FOR ALZHEIMER'S DISEASE
    MICHAEL VIOLA; Fiscal Year: 1992
    ..21q11-q22 will also be dissected from Dutch patients with hereditary cerebral hemorrhage with amyloidosis (HCHA-D) to determine if different APP mutations induce varying phenotypes in transgenic ..
  34. STUDY ON A NOVEL ALZHEIMER APP REGULATORY FACTOR
    Wolfgang Quitschke; Fiscal Year: 2006
    ..They also occur in Down syndrome and hereditary cerebral hemorrhage with amyloidosis of the Dutch type and to a lesser degree in the normal aging brain...
  35. LASER SCANNING CONFOCAL MICROSCOPE
    Ralph Nixon; Fiscal Year: 2005
    ..intervention in animal models; 2) Expression Profiling in Neurodegenerative Disorders; 3) Cystatin C in cerebral hemorrhage and in Alzheimer's disease (AD); 4) The endocytic pathway in AD and Down's Syndrome; 5) The endosomal-..
  36. Cancer Detection using Diffuse Luminescence Imaging
    ARIEH KARGER; Fiscal Year: 2004
    ..Other applications could include brain imaging to monitor cerebral function or cerebral hemorrhage, and monitoring tissue and muscle oxygenation.
  37. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  38. MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2004
    ..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
  39. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Marc Simard; Fiscal Year: 2007
    ..abstract_text> ..
  40. Cerebral Hemorrhage Model: Mechanisms and Treatments
    Kenneth Wagner; Fiscal Year: 2005
    ..abstract_text> ..
  41. Genetic Risks for Medication-Related Hemorrhagic Stroke
    Steven Greenberg; Fiscal Year: 2007
    ..This proposal is thus likely to form the foundation of a powerful, open-ended search for a panel of genetic tests to determine an individual's risk for Warfarin-related ICH. ..
  42. NC-758 for Prevention of Recurrent Cerebral Hemorrhage
    Steven Greenberg; Fiscal Year: 2005
    ..In addition to testing a promising agent for CAA, the proposed study will generate the organization and pilot data to serve as a springboard for future trials of emerging anti-amyloid treatments. ..
  43. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....
  44. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  45. Secondary Brain Injury in Intracerebral Hemorrhage
    JESSE HEMPHILL; Fiscal Year: 2005
    ..In conjunction with the didactic training and mentoring undertaken, this program will foster Dr. Hemphill's development into an independent researcher in neurologic critical care, specifically focusing on intracerebral hemorrhage. ..
  46. Detection of neonatal ventricular hemorrhage using EIT
    Rosalind Sadleir; Fiscal Year: 2006
    ..These data will be analyzed to determine the best way of separating artifacts produced by shape changes and other body impedance changes from the bleeding process. ..
  47. Optimizing Heme Oxygenase Activity after CNS Hemorrhage
    Raymond Regan; Fiscal Year: 2009
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  48. Safety and Tolerability of Deferoxamine in Acute Cerebral Hemorrhage
    Magdy H Selim; Fiscal Year: 2010
    ..ICH is a frequent cause of disability and death. A successful study demonstrating the efficacy of iron-modifying therapy would be of considerable public health significance. ..
  49. Animal models for cerebral amyloid angiopathy
    Efrat Levy; Fiscal Year: 2006
    A L68Q variant cystatin C forms the amyloid deposited in cerebral vessel walls of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type...
  50. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
  51. MECHANISMS OF SECONDARY INJURY IN CEREBRAL HEMORRHAGE
    ALLYSON ZAZULIA; Fiscal Year: 2007
    ..These hypotheses will be tested using sequential PET or MRI studies in 60 patients with acute ICH. ..
  52. BETAAPP MODULATION BY THE ADAPTER PROTEINS FE65 AND X11
    Efrat Levy; Fiscal Year: 2003
    ..Manipulating the interaction of Beta-APP with an effector protein, such as X11 or Fe65, may provide a novel approach for the pharmacological modulation of Beta-APP processing in Alzheimer's disease. ..
  53. Simvastatin treatment of experimental intracerebral hemorrhage
    DONALD M SEYFRIED; Fiscal Year: 2010
    ....
  54. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond F Regan; Fiscal Year: 2010
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  55. Quantitation of Early Vascular Leakage after Stroke
    Patrick Lyden; Fiscal Year: 2006
    ..3. Validate that FITC-dextran blood brain barrier breakdown correlates with in vivo measures of low blood flow in microvessels. ..
  56. PARAMEDIC FIELD INITIATION OF MAGNESIUM NEUROPROTECTIVE
    Jeffrey Saver; Fiscal Year: 2003
    ..abstract_text> ..
  57. ACTION - A CHF Trial Investigating Outcomes of Exercise
    Gregg Fonarow; Fiscal Year: 2006
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  58. Venoarterial ECMO and neonatal cerebrovascular injury
    Billie Short; Fiscal Year: 2004
    ..These studies will also improve our understanding of the underlying mechanisms of ECMO-induced injury of cerebral arterial endothelium, and impairment in CBF autoregulation. ..
  59. STRESS GENES AND HEMORRHAGIC BRAIN INJURY
    Frank Sharp; Fiscal Year: 2001
    ..These studies will help delineate mechanisms of injury following subarachnoid hemorrhage, and will develop a new approach for assessing whether drugs decrease or block injury due to subarachnoid hemorrhage. ..