cerebral hemorrhage

Summary

Summary: Bleeding into a cerebral hemisphere of the brain, including lobar, subcortical white matter, and basal ganglia hemorrhages. Commonly associated conditions include HYPERTENSION; INTRACRANIAL ARTERIOSCLEROSIS; INTRACRANIAL ANEURYSM; CRANIOCEREBRAL TRAUMA; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; CEREBRAL AMYLOID ANGIOPATHY; and CEREBRAL INFARCTION.

Top Publications

  1. ncbi Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Ann Neurol 61:352-62. 2007
  2. pmc Cerebral microbleeds: a guide to detection and interpretation
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet Neurol 8:165-74. 2009
  3. ncbi High-dose atorvastatin after stroke or transient ischemic attack
    Pierre Amarenco
    Denis Diderot University, Paris
    N Engl J Med 355:549-59. 2006
  4. ncbi Mechanisms of brain injury after intracerebral haemorrhage
    Guohua Xi
    Department of Neurosurgery, University of Michigan, E Medical Centre Drive, Ann Arbor, MI 48109 0338, USA
    Lancet Neurol 5:53-63. 2006
  5. ncbi The ABCs of measuring intracerebral hemorrhage volumes
    R U Kothari
    Department of Emergency Medicine, University of Cincinnati, Ohio 45267 0769, USA
    Stroke 27:1304-5. 1996
  6. ncbi The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage
    Jonathan Rosand
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Arch Intern Med 164:880-4. 2004
  7. ncbi Molecular signatures of brain injury after intracerebral hemorrhage
    J Castillo
    Department of Neurology, Hospital Clinico Universitario, Santiago de Compostela, Spain
    Neurology 58:624-9. 2002
  8. ncbi Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
  9. doi Hematoma resolution as a therapeutic target: the role of microglia/macrophages
    Xiurong Zhao
    Professor of Neurology, Director of Stroke Research, Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Stroke 40:S92-4. 2009
  10. pmc Minocycline reduces intracerebral hemorrhage-induced brain injury
    Jimin Wu
    Medical School, Zhejiang University, Hangzhou, China Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neurol Res 31:183-8. 2009

Research Grants

  1. CEREBRAL HEMORRHAGE MODEL--MECHANISMS AND TREATMENTS
    Kenneth Wagner; Fiscal Year: 1999
  2. Regulation of neural cell volume by thrombin receptors
    Tooba Cheema; Fiscal Year: 2006
  3. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
  4. A platelet ligand mimetic for neurothrombotic disorders
    Catherine Woods; Fiscal Year: 2006
  5. AbetaPP and Cerebral Vasculopathy
    William Van Nostrand; Fiscal Year: 2006
  6. Transgenic Model for Cerebral Amyloid Angiopathy
    William Van Nostrand; Fiscal Year: 2006
  7. Plasminogen Activation & SK: Structure-Function
    Guy Reed; Fiscal Year: 2009
  8. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
  9. Plasminogen Activation & SK: Structure-Function
    Guy L Reed; Fiscal Year: 2010
  10. CEREBRAL HEMORRHAGE MODEL--MECHANISMS AND TREATMENTS
    Kenneth Wagner; Fiscal Year: 1993

Detail Information

Publications262 found, 100 shown here

  1. ncbi Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Ann Neurol 61:352-62. 2007
    ..Promotion of phagocytosis in a timely and efficient manner may limit the toxic effects of persistent blood products on surrounding tissue and may be important for recovery after ICH...
  2. pmc Cerebral microbleeds: a guide to detection and interpretation
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet Neurol 8:165-74. 2009
    ..We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease...
  3. ncbi High-dose atorvastatin after stroke or transient ischemic attack
    Pierre Amarenco
    Denis Diderot University, Paris
    N Engl J Med 355:549-59. 2006
    ..Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established...
  4. ncbi Mechanisms of brain injury after intracerebral haemorrhage
    Guohua Xi
    Department of Neurosurgery, University of Michigan, E Medical Centre Drive, Ann Arbor, MI 48109 0338, USA
    Lancet Neurol 5:53-63. 2006
    ..This review addresses our current understanding of the mechanisms underlying ICH-induced brain injury...
  5. ncbi The ABCs of measuring intracerebral hemorrhage volumes
    R U Kothari
    Department of Emergency Medicine, University of Cincinnati, Ohio 45267 0769, USA
    Stroke 27:1304-5. 1996
    ..Hemorrhage volume is a powerful predictor of 30-day mortality after spontaneous intracerebral hemorrhage (ICH). We compared a bedside method of measuring CT ICH volume with measurements made by computer-assisted planimetric image analysis...
  6. ncbi The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage
    Jonathan Rosand
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Arch Intern Med 164:880-4. 2004
    ..We studied the determinants of ICH outcome to quantify the independent effect of warfarin...
  7. ncbi Molecular signatures of brain injury after intracerebral hemorrhage
    J Castillo
    Department of Neurology, Hospital Clinico Universitario, Santiago de Compostela, Spain
    Neurology 58:624-9. 2002
    ..The mechanisms of cellular death in the tissue surrounding an intracerebral hemorrhage (ICH) are not defined...
  8. ncbi Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
    ..Here, we have used conditional knockout technology to address whether the cerebral hemorrhage is due to primary defects in vascular or neural cell types...
  9. doi Hematoma resolution as a therapeutic target: the role of microglia/macrophages
    Xiurong Zhao
    Professor of Neurology, Director of Stroke Research, Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Stroke 40:S92-4. 2009
    ..Proxisome proliferator activated receptor-gamma agonists could represent a potential treatment strategy for treatment of ICH...
  10. pmc Minocycline reduces intracerebral hemorrhage-induced brain injury
    Jimin Wu
    Medical School, Zhejiang University, Hangzhou, China Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neurol Res 31:183-8. 2009
    ..The present study investigated if thrombin stimulates tumor necrosis factor-alpha and interleukin-1beta secretion in vitro and if microglial inhibition reduces intracerebral hemorrhage-induced brain injury in vivo...
  11. doi Rapid appearance of new cerebral microbleeds after acute ischemic stroke
    S B Jeon
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, Republic of Korea
    Neurology 73:1638-44. 2009
    ..We hypothesized that MBs may develop rapidly after certain critical events, such as strokes, and investigated the frequency, location, and factors associated with the formation of new MBs after acute ischemic stroke...
  12. ncbi Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Out
    Joseph Broderick
    Stroke 38:2001-23. 2007
    ..The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous intracerebral hemorrhage...
  13. doi The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population
    Lijun Wu
    First Affiliated Hospital, Medical College of Shantou University, Shantou, China
    Stroke 40:2973-6. 2009
    ..The 1425G/A SNP in PRKCH (rs2230500) is significantly associated with ischemic stroke in Japanese. The aim of the present study is to investigate the associations in ischemic stroke and other types of stroke in the Chinese population...
  14. ncbi Inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Cereb Blood Flow Metab 27:894-908. 2007
    ..In the near future, additional strategies that target inflammation could offer exciting new promise in the therapeutic approach to ICH...
  15. ncbi Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
    Martin C Herzig
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    Nat Neurosci 7:954-60. 2004
    ..In contrast to Alzheimer disease (AD), the brains of those affected by hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) show few parenchymal amyloid plaques...
  16. ncbi Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
    E Levy
    Department of Pathology, New York University Medical Center, NY 10016
    Science 248:1124-6. 1990
    An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with ..
  17. ncbi Risk factors for intracerebral hemorrhage in the general population: a systematic review
    M J Ariesen
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
    Stroke 34:2060-5. 2003
    ..Although data on some risk factors for intracerebral hemorrhage (ICH) already are beyond doubt, for other factors, the evidence is less clear. We performed a systematic overview of case-control and cohort studies on risk factors for ICH...
  18. ncbi Heme and iron metabolism: role in cerebral hemorrhage
    Kenneth R Wagner
    Departments of Neurology, Pediatrics and Neuroscience Programl, Unviersity of Cincinnati College of Medicine, Cincinnati, Ohio 45220, USA
    J Cereb Blood Flow Metab 23:629-52. 2003
    ..After a cerebral hemorrhage, large numbers of hemoglobin-containing red blood cells are released into the brain's parenchyma and/or ..
  19. ncbi Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting
    Charlotte Cordonnier
    Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK
    Brain 130:1988-2003. 2007
    ..We conclude by proposing criteria for ideal study design and reporting...
  20. ncbi Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles
    R Natte
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Ann Neurol 50:765-72. 2001
    ..the amount of cerebral amyloid angiopathy and the presence of dementia in 19 patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type...
  21. doi Three-year survival and stroke recurrence rates in patients with primary intracerebral hemorrhage
    Elisabet Zia
    Cardiovasular Epidemiology Research Group, Department of Neurology, A, Malmo University Hospital, Institution of Clinical Sciences in Malmö, University of Lund, Lund, Sweden
    Stroke 40:3567-73. 2009
    ..Our aim was to evaluate mortality and stroke recurrence rates in relation to hemorrhage characteristics, demographic and clinical factors, in a large unselected patient cohort...
  22. ncbi Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products
    Feng ping Huang
    Department of Neurosurgery, University of Michigan, Ann Arbor 48109 0532, USA
    J Neurosurg 96:287-93. 2002
    ..The authors have found that red blood cell lysis plays an important role in edema development after ICH. In the present study, they sought to determine whether degradation products of hemoglobin cause brain edema...
  23. pmc Intracerebral haemorrhage
    Adnan I Qureshi
    Zeenat Qureshi Stroke Research Center, Department of Neurology and Neurosurgery, University of Minnesota, MN, Minnesota 55455, USA
    Lancet 373:1632-44. 2009
    ..These approaches improve clinical management of patients with intracerebral haemorrhage and promise to reduce mortality and increase functional survival...
  24. ncbi Early care limitations independently predict mortality after intracerebral hemorrhage
    D B Zahuranec
    Stroke Program, University of Michigan Medical School, Ann Arbor, MI 48109 0316, USA
    Neurology 68:1651-7. 2007
    ..Intracerebral hemorrhage (ICH) is associated with a high early mortality rate. We examined the impact of early do not resuscitate (DNR) orders and other limitations in aggressive care on mortality after ICH in a community-based study...
  25. doi Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry
    Simona Sacco
    Department of Neurology, University of L Aquila, L Aquila, Italy
    Stroke 40:394-9. 2009
    ..The purpose of this study was to evaluate the incidence and prognosis of intracerebral hemorrhage...
  26. ncbi Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke
    Maarten G Lansberg
    Stanford University, Stanford Stroke Center, Palo Alto, California 94304, USA
    Stroke 38:2275-8. 2007
    ..MRI-based variables have generally not been included in predictive models, and little is known about the influence of reperfusion on SICH risk...
  27. doi Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats
    Jason K Wasserman
    Toronto Western Research Institute, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada
    Eur J Neurosci 28:1316-28. 2008
    ..These findings have important implications for efforts to reduce secondary injury after ICH and to develop anti-inflammatory therapies to treat ICH in aged humans...
  28. pmc Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study
    Seung Hoon Lee
    Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea
    PLoS ONE 6:e25930. 2011
    ..Cerebral microbleeds (MBs) are understood as an important radiologic marker of intracerebral hemorrhage. We sought to investigate the temporal changes of MBs and clinical factors associated with the changes using long-term follow-up MRI...
  29. doi The development of an improved preclinical mouse model of intracerebral hemorrhage using double infusion of autologous whole blood
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res 1222:214-21. 2008
    ....
  30. doi Density and shape as CT predictors of intracerebral hemorrhage growth
    Christen D Barras
    Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Stroke 40:1325-31. 2009
    ..We hypothesized that irregular hematoma shape and density heterogeneity, reflecting active, multifocal bleeding or a variable bleeding time course, would predict ICH growth...
  31. doi Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome
    V De Herdt
    Universite Lille Nord de France, Neurology Department, Lille, France
    Neurology 77:1794-800. 2011
    ..Therefore, we aimed to identify incidence, associated factors, and influence on outcome of ES in patients with ICH...
  32. ncbi Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema
    Marie France Penet
    Centre de Resonance Magnetique Biologique et Medicale, Unite Mixte de Recherche Centre National de la Recherche Scientifique 6612, 13005 Marseille, France
    J Neurosci 25:7352-8. 2005
    ..They improve our understanding of the pathogenesis of cerebral malaria and may provide the necessary noninvasive surrogate markers for quantitative monitoring of treatment...
  33. ncbi Ethnic disparities in incidence of stroke subtypes: Auckland Regional Community Stroke Study, 2002-2003
    Valery Feigin
    Clinical Trials Research Unit, Department of Medicine and School of Population Health, Faculty of Medicine and Health Sciences, University of Auckland, New Zealand
    Lancet Neurol 5:130-9. 2006
    ..We aimed to provide such data within the large multi-ethnic population of Auckland, New Zealand...
  34. doi c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage
    Delphine Michel-Monigadon
    Department of Clinical Neuroscience, Neurology Service, Centre Hospitalier Universitaire Vaudois and Lausanne University, Lausanne, Switzerland
    Cerebrovasc Dis 29:564-70. 2010
    ..We investigated the effect of JNK inhibition in intracerebral hemorrhage (ICH)...
  35. ncbi Treatment of acute hypertension in patients with intracerebral hemorrhage using American Heart Association guidelines
    Adnan I Qureshi
    Clinical Trials Division, Zeenat Qureshi Stroke Research Center, Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Crit Care Med 34:1975-80. 2006
    ....
  36. ncbi The ICH score: a simple, reliable grading scale for intracerebral hemorrhage
    J C Hemphill
    Department of Neurology, University of California, San Francisco, USA
    Stroke 32:891-7. 2001
    ..Despite several existing outcome prediction models for ICH, there is no standard clinical grading scale for ICH analogous to those for traumatic brain injury, subarachnoid hemorrhage, or ischemic stroke...
  37. ncbi Experimental intracerebral hemorrhage in the mouse: histological, behavioral, and hemodynamic characterization of a double-injection model
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, FL 33101, USA
    Stroke 34:2221-7. 2003
    ..We investigated the effect of intrastriatal injection of blood or cerebrospinal fluid (CSF) on cerebral blood flow (CBF), neurological score, hematoma volume, and brain swelling...
  38. ncbi Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI
    David J Werring
    Stroke Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 127:2265-75. 2004
    ..These findings have implications for the diagnosis of stroke patients with cognitive impairment, and for the appropriate use of antihypertensive and antiplatelet treatments in these patients...
  39. doi HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats
    Masatoshi Ohnishi
    Department of Pharmacotherapeutics, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima, Japan
    Neuropharmacology 61:975-80. 2011
    ..Moreover, glycyrrhizin partially but significantly ameliorated ICH-induced neuron loss inside hematoma. These findings suggest that an HMGB1 inhibitor glycyrrhizin is a potential candidate for a remedy for ICH...
  40. ncbi Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT)
    Takenori Yamaguchi
    National Cardiovascular Center, Suita, Osaka, Japan
    Stroke 37:1810-5. 2006
    ..6 mg/kg, which is lower than the internationally approved dosage of 0.9 mg/kg, aiming to assess the efficacy and safety of alteplase in acute ischemic stroke for the Japanese...
  41. pmc MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength
    R N K Nandigam
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 30:338-43. 2009
    ....
  42. pmc Microbleeds versus macrobleeds: evidence for distinct entities
    Steven M Greenberg
    MGH Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2382-6. 2009
    ..It is unclear whether microbleeds and macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies...
  43. doi Brain microbleeds and Alzheimer's disease: innocent observation or key player?
    Charlotte Cordonnier
    Univ Lille Nord de France, CHU Lille, EA 1046 Pôle de neurologie F 59000 Lille, France
    Brain 134:335-44. 2011
    ..We also review the available evidence and highlight the pitfalls of our current knowledge on brain microbleeds in the setting of clinical trials design...
  44. pmc Neuroprotective role of haptoglobin after intracerebral hemorrhage
    Xiurong Zhao
    Stroke Program, Department of Neurology, University of Texas Health Science Center, Medical School at Houston, Houston, Texas 77030, USA
    J Neurosci 29:15819-27. 2009
    ..We conclude that Hp, particularly the brain-derived Hp, plays cytoprotective roles and represents a potential therapeutic target for ICH treatment...
  45. ncbi Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage
    S M Davis
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    Neurology 66:1175-81. 2006
    ..Although volume of intracerebral hemorrhage (ICH) is a predictor of mortality, it is unknown whether subsequent hematoma growth further increases the risk of death or poor functional outcome...
  46. ncbi Sex differences in US mortality rates for stroke and stroke subtypes by race/ethnicity and age, 1995-1998
    Carma Ayala
    Cardiovascular Health Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Stroke 33:1197-201. 2002
    ..Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/ethnicity...
  47. ncbi The role of endogenous versus exogenous tPA on edema formation in murine ICH
    Ruth Thiex
    Department of Neurosurgery, Aachen University, Aachen, Germany
    Exp Neurol 189:25-32. 2004
    ..In conclusion, the role of the endogenous tPA appears to be limited to the early phase of edema formation, whereas exogenous rtPA is edema-promoting between days 3 and 7 after ICH...
  48. ncbi Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats
    Toshihisa Sumii
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
    Stroke 33:831-6. 2002
    ..In this study we used a previously established quantitative rat model of tPA-associated hemorrhage to test the hypothesis that matrix metalloproteinases (MMPs) are involved...
  49. ncbi Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly
    Douglas B Gould
    Howard Hughes Medical Institute, Bar Harbor, ME 04609, USA
    Science 308:1167-71. 2005
    ..Half of the mutant mice died with cerebral hemorrhage within a day of birth, and approximately 18% of survivors had porencephaly...
  50. pmc Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins
    Joseph H McCarty
    Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 22:7667-77. 2002
    ..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
  51. doi Hemorrhagic and ischemic strokes compared: stroke severity, mortality, and risk factors
    Klaus Kaae Andersen
    Informatics and Mathematical Modelling, Section for Statistics, Technical University of Denmark, Lyngby, Denmark
    Stroke 40:2068-72. 2009
    ..Stroke patients with hemorrhagic (HS) and ischemic strokes were compared with regard to stroke severity, mortality, and cardiovascular risk factors...
  52. ncbi White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome
    J M Perlman
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas 75235 9063, USA
    Early Hum Dev 53:99-120. 1998
    ..A clearer understanding of pathogenesis of both conditions is essential so as to provide targeted preventative strategies...
  53. ncbi Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794 8651, USA
    Stroke 36:613-8. 2005
    ..In this study, we investigate the protection and efficacy of treatment when MIF is administered 2 hours after collagenase injection...
  54. ncbi Acute inflammatory reaction following experimental intracerebral hemorrhage in rat
    C Gong
    Department of Neurosurgery, University of Michigan, R5605 Kresge I, P O Box 0532, 1500 East Medical Center Drive, 48109 0532, Ann Arbor, MI, USA
    Brain Res 871:57-65. 2000
    ..We hypothesized that inflammatory mediators released from the blood after cerebral hemorrhage might cause secondary brain injury and edema formation...
  55. ncbi Grading scale for prediction of outcome in primary intracerebral hemorrhages
    José L Ruiz-Sandoval
    Department of Neurology and Neurosurgery, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico
    Stroke 38:1641-4. 2007
    ..This study aimed to independently derive an intracerebral hemorrhage grading scale (ICH-GS) for prediction of 3 outcome measures...
  56. ncbi Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study
    Daniel Woo
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    Stroke 33:1190-5. 2002
    ..We report a preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of ICH...
  57. ncbi Aspirin and risk of hemorrhagic stroke: a meta-analysis of randomized controlled trials
    J He
    Department of Biostatistics and Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    JAMA 280:1930-5. 1998
    ..Aspirin has been widely used to prevent myocardial infarction and ischemic stroke but some studies have suggested it increases risk of hemorrhagic stroke...
  58. ncbi Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:1415-20. 2004
    ..We sought to determine whether hemorrhages detected at the time of lobar ICH predict the major clinical complications of CAA: recurrent ICH or decline in cognition and function...
  59. ncbi Prediction of death in patients with primary intracerebral hemorrhage: a prospective study of a defined population
    Ola G Nilsson
    Department of Neurosurgery, Lund University Hospital, Sweden
    J Neurosurg 97:531-6. 2002
    ..Predictors of early (30-day) and long-term (1-year) mortality rates after primary intracerebral hemorrhage (ICH) were studied in a large population in southern Sweden...
  60. ncbi Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage
    Y Fujii
    Department of Neurosurgery, Niigata University, Japan
    Stroke 29:1160-6. 1998
    ..We conducted this study to determine, through use of multivariate analyses, the independent predictors of hematoma enlargement occurring after hospital admission in patients with spontaneous intracerebral hemorrhage (i.c.h.)...
  61. doi Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke
    A H Cho
    Department of Neurology, The Catholic University of Korea, St Mary s Hospital, Young Dung Po Gu, Seoul 150 713, South Korea
    Neurology 73:1645-8. 2009
    ..We investigated the association between the presence of cerebral microbleeds and poor kidney function in patients with acute ischemic stroke...
  62. doi Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP
    Orso Bugiani
    Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11 20133, Milan, Italy
    Arch Neurol 67:987-95. 2010
    To report the clinical, genetic, neuroimaging, and neuropathologic studies of patients with the hereditary cerebral hemorrhage with amyloidosis linked to the APP E693K mutation.
  63. ncbi High blood pressure in acute stroke and subsequent outcome: a systematic review
    Mark Willmot
    Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Hypertension 43:18-24. 2004
    ..Moderate lowering of BP might improve outcome. Acute BP lowering needs to be tested in 1 or more large, randomized trials...
  64. ncbi Racial variations in location and risk of intracerebral hemorrhage
    Matthew L Flaherty
    Department of Neurology, University of Cincinnati Medical Center, Ohio 45267 0525, USA
    Stroke 36:934-7. 2005
    ..Incidence rates of ICH are known to be higher in American blacks than whites, but how rates may differ by hemorrhage location is unknown. We sought to define incidence rates for different ICH locations in a biracial population...
  65. ncbi Intracerebral hemorrhage models in rat: comparing collagenase to blood infusion
    Crystal L MacLellan
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    J Cereb Blood Flow Metab 28:516-25. 2008
    ..Thus, both should be used whenever possible taking into account the significant differences between these models and their limitations. Furthermore, this work illustrates significant weaknesses with several outcome measures...
  66. pmc Intraventricular hemorrhage: severity factor and treatment target in spontaneous intracerebral hemorrhage
    Daniel F Hanley
    Division of Brain Injury Outcomes, Johns Hopkins School of Medicine, CRB II, Baltimore, MD 21231, USA
    Stroke 40:1533-8. 2009
    ..Initial efforts are encouraging that increased survival and functional improvement can be achieved. Little controversy exists regarding the need to scientifically investigate treatment of this severity factor...
  67. pmc Stereotactic aspiration-thrombolysis of intracerebral hemorrhage and its impact on perihematoma brain edema
    J Ricardo Carhuapoma
    Division of Neurosciences Critical Care, Departments of Neurology, Neurosurgery and Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 8 140, Baltimore, MD 21287, USA
    Neurocrit Care 8:322-9. 2008
    ..To test this hypothesis, we report on the volumetric analysis of (1) the intraparenchymal hematoma and, (2) perihematomal edema in a cohort of ICH patients treated with intraclot rtPA...
  68. pmc Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, 720 Rutland Ave, Traylor Bldg 809, Baltimore, MD 21205, USA
    Brain 130:1643-52. 2007
    ..These data reveal a previously unrecognized role of HO-1 in early brain injury after ICH. Thus, modulation of HO-1 signalling should be assessed further in clinical settings, especially for haemorrhagic states...
  69. doi Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage
    Paraskevi Georgiadis
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY, USA
    Stroke 39:3378-88. 2008
    ..Despite this, there is no standardized animal model of IVH depicting acute brain injuries...
  70. doi Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis
    Charlotte Jj van Asch
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet Neurol 9:167-76. 2010
    ..We aimed to assess the incidence, case fatality, and functional outcome of intracerebral haemorrhage in relation to age, sex, ethnic origin, and time period in studies published since 1980...
  71. ncbi Apoptosis as a form of cell death in intracerebral hemorrhage
    Adnan I Qureshi
    Department of Neurosurgery and Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA
    Neurosurgery 52:1041-7; discussion 1047-8. 2003
    ..Recent evidence from laboratory models suggests that cell death in the perihematoma region may involve apoptosis...
  72. doi Random forest can predict 30-day mortality of spontaneous intracerebral hemorrhage with remarkable discrimination
    S Y Peng
    Institute of Biomedical Informatics, National Yang Ming University, Taipei, Taiwan
    Eur J Neurol 17:945-50. 2010
    ..We evaluated the accuracy and discriminating power of the random forest (RF) to predict 30-day mortality of spontaneous intracerebral hemorrhage (SICH)...
  73. doi The acute management of intracerebral hemorrhage: a clinical review
    Justine Elliott
    Department of Neuroanaesthesia and Neurocritical Care, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK
    Anesth Analg 110:1419-27. 2010
    ..There is an increasing awareness that aggressive management in the acute phase can translate into improved outcomes after ICH...
  74. pmc Preclinical and clinical research on inflammation after intracerebral hemorrhage
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Traylor Building 809, Baltimore, MD 21205, USA
    Prog Neurobiol 92:463-77. 2010
    ....
  75. doi Intensive care management of acute stroke: surgical treatment
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 5:170-7. 2010
    ..Most recently, hopeful preliminary data have emerged on new approaches in the treatment of intraventricular haemorrhage. In this article, we review the current neurosurgical options in acute ischaemic and haemorrhagic stroke...
  76. ncbi Surgery for primary intracerebral hemorrhage: is it safe and effective? A systematic review of case series and randomized trials
    G J Hankey
    Department of Neurology, Royal Perth Hospital, Western Australia, Australia
    Stroke 28:2126-32. 1997
    ..This study compares the outcome of patients with PICH who are treated surgically with those who are not...
  77. ncbi Ultra-early clot aspiration after lysis with tissue plasminogen activator in a porcine model of intracerebral hemorrhage: edema reduction and blood-brain barrier protection
    K R Wagner
    Department of Neurology, University of Cincinnati College of Medicine, Ohio, USA
    J Neurosurg 90:491-8. 1999
    ..Ultra-early hematoma evacuation (< 4 hours) after intracerebral hemorrhage (ICH) may reduce mass effect and edema development and improve outcome. To test this hypothesis, the authors induced lobar hematomas in pigs...
  78. pmc Neurogenesis after primary intracerebral hemorrhage in adult human brain
    Jianfeng Shen
    Department of Neurosurgery, First Affiliated Hospital, Zhejiang University College of Medicine, Zhejiang, China
    J Cereb Blood Flow Metab 28:1460-8. 2008
    ..Our data suggest that intracerebral hemorrhage induces neurogenesis in the adult human brain...
  79. ncbi Iron and iron-handling proteins in the brain after intracerebral hemorrhage
    Jimin Wu
    Department of Neurosurgery, University of Michigan, Ann Arbor 48109 0532, USA
    Stroke 34:2964-9. 2003
    ..Therefore, we examined whether such iron is cleared from the brain and the effects of ICH on proteins that may alter iron release or handling: brain heme oxygenase-1, transferrin, transferrin receptor, and ferritin...
  80. ncbi Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduced levels of extracellular cerebral glutamate and unchanged lactate pyruvate ratios
    Chad M Miller
    Division of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Neurocrit Care 6:22-9. 2007
    ..The purpose of this study is to characterize the neurochemical changes in perihematomal tissue during frameless minimally invasive evacuation of spontaneous hematomas...
  81. ncbi Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome
    Jose Alvarez-Sabin
    Neurovascular Research Laboratory and the Stroke Unit, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Stroke 35:1316-22. 2004
    ..We aimed to investigate the temporal profile of MMPs and their natural inhibitors (TIMPs) after acute intracerebral hemorrhage (ICH) and to study its influence on neuroimaging and clinical outcome...
  82. ncbi Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications
    Hans Christian Koennecke
    Department of Neurology, Evangelisches Krankenhaus Konigin Elisabeth Herzberge, Berlin, Germany
    Neurology 66:165-71. 2006
    ..To assess the potential role of cerebral microbleeds (CMB) in intracerebral hemorrhage (ICH), as indicators of cerebral small-vessel disease, and their possible implications for antithrombotic treatment...
  83. ncbi Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression
    Xiurong Zhao
    Department of Neurology, Stroke Program, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Neurochem 101:652-63. 2007
    ..In summary, NF-kappaB activation occurs within minutes and persists for at least a week in response to ICH. This reaction utilizes different NF-kappaB regulatory subunits and is associated with the expression of selected target genes...
  84. ncbi Hospital cost of ischemic stroke and intracerebral hemorrhage in Japanese stroke centers
    Yukihiro Yoneda
    Division of Neurology, Hyogo Brain and Heart Center and Kobe Red Cross Hospital, 1 3 1 Wakihama Bay Street, Chuo Ku, Kobe 651 0073, Japan
    Health Policy 73:202-11. 2005
    ..In Japan, the healthcare expenditure has increased to 8.0% of the gross domestic products in 2001. Stroke care is costly...
  85. doi Variation in the frequency of intracerebral haemorrhage and ischaemic stroke in China: a national, multicentre, hospital register study
    Jade W Wei
    The George Institute for International Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, NSW, Australia jwei george org au
    Cerebrovasc Dis 29:321-7. 2010
    ..Intracerebral haemorrhage (ICH) accounts for about one third of all strokes in China, a proportion that is three times higher than in Western populations. We aimed to determine the frequency distribution of ICH in China...
  86. pmc Molecular pathophysiology of cerebral hemorrhage: secondary brain injury
    Jaroslaw Aronowski
    University of Texas HSC, Medical School, Department of Neurology, 6431 Fannin, Rm 7 210, Houston, TX 77030, USA
    Stroke 42:1781-6. 2011
    ....
  87. ncbi Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage
    Yolanda Silva
    Department of Neurology, Hospital Doctor Josep Trueta, Girona, Spain
    Stroke 36:86-91. 2005
    ..To investigate whether molecular markers of inflammation and endothelial injury are associated with early growth of intracerebral hemorrhage (ICH)...
  88. pmc Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem study
    He Wu
    Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, PR China
    Brain Res 1342:111-7. 2010
    ..These data suggest that inflammation occurs early and persists for several days after ICH in humans and could be involved in the progression of ICH-induced secondary brain damage...
  89. doi Brain microbleeds as a potential risk factor for antiplatelet-related intracerebral haemorrhage: hospital-based, case-control study
    S M Gregoire
    Stroke Research Group, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 81:679-84. 2010
    ..The authors hypothesised that microbleeds are a risk factor for antiplatelet-related ICH, and investigated this in a hospital-based matched case-control study...
  90. ncbi Surgery for spontaneous intracerebral hemorrhage has greater remedial value than conservative therapy
    Jun Morioka
    Department of Neurosurgery, Yamaguchi University School of Medicine, Yamaguchi 755 8505, Japan
    Surg Neurol 65:67-72; discussion 72-3. 2006
    ..The aim of this study was to compare the efficacy of surgery for spontaneous intracerebral hemorrhage with that of medical treatment, based on data from the Japan Stroke Registry Study...
  91. doi Efficacy and safety of anticoagulants in the prevention of venous thromboembolism in patients with acute cerebral hemorrhage: a meta-analysis of controlled studies
    M Paciaroni
    Stroke Unit, Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 9:893-8. 2011
    ..We performed an updated meta-analysis of studies to obtain the best estimates of the efficacy and safety of anticoagulants for the prevention of venous thromboembolism in patients with acute hemorrhagic stroke...
  92. doi Effects of combination treatment of dexamethasone and melatonin on brain injury in intracerebral hemorrhage model in rats
    Zhi qing Li
    Department of Neurosurgery, Shenyang Northern Hospital, Shenyang, China
    Brain Res 1264:98-103. 2009
    ..Taken together, our results clearly indicated for the first time that strategies targeting multiple proinflammatory pathways may be more effective than a single effector molecule for the treatment of ICH...
  93. doi Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds
    Yannie O Y Soo
    Division of Neurology, Dept of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong
    J Neurol 255:1679-86. 2008
    ..Retrospective studies suggested that cerebral microbleeds (MB) on magnetic resonance images (MRI) increase risk of intracerebral haemorrhage (ICH)...
  94. doi Estimating the long-term costs of ischemic and hemorrhagic stroke for Australia: new evidence derived from the North East Melbourne Stroke Incidence Study (NEMESIS)
    Dominique A Cadilhac
    National Stroke Research Institute, Victoria, Australia
    Stroke 40:915-21. 2009
    ..NEMESIS now has patient-level resource use data for 5 years. We aimed to recalculate the long-term resource utilization of first-ever stroke patients and compare these to previous estimates obtained using data collected to 12 months...
  95. ncbi Outcome assignment in the International Surgical Trial of Intracerebral Haemorrhage
    A D Mendelow
    Surgical Trial of Intracerebral Haemorrhage STICH, Newcastle General Hospital, Newcastle upon Tyne, UK
    Acta Neurochir (Wien) 145:679-81; discussion 681. 2003
  96. ncbi Cerebral vascular accumulation of Dutch-type Abeta42, but not wild-type Abeta42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type
    Kazuchika Nishitsuji
    Department of Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 85:2917-23. 2007
    Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D), is an autosomal dominant disorder caused by the Dutch mutation (E693Q) in the beta-amyloid precursor protein...
  97. pmc Surgical management and case-fatality rates of intracerebral hemorrhage in 1988 and 2005
    Opeolu Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
    Neurosurgery 63:1113-7; discussion 1117-8. 2008
    ..To compare surgical management and case-fatality rates of intracerebral hemorrhage (ICH) in 1988 and 2005...
  98. ncbi Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats
    Tadashi Masuda
    Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Neurosci Lett 425:114-9. 2007
    ..These data suggest that collagenase-induced ICH enhances the proliferation of endogenous NPCs and the migration of newly born neuroblasts toward the hemorrhage area...
  99. ncbi The risk factors for infections acquired by cerebral hemorrhage and cerebral infarct patients in a neurology intensive care unit in Turkey
    Gul Ruhsar Yilmaz
    Infectious Diseases and Clinical Microbiology Department, Ankara Training and Research Hospital, Ankara, Turkey
    Jpn J Infect Dis 60:87-91. 2007
    ..In this study, the risk factors for ICU-acquired infections in patients with cerebral hemorrhage and cerebral infarct who were treated for more than 24 h at the Ankara Training and Research Hospital were ..
  100. doi Matrix metalloproteinases in intracerebral hemorrhage
    Mengzhou Xue
    Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, Alta, Canada
    Neurol Res 30:775-82. 2008
    ..The objective of this study is to review the role of matrix metalloproteinases in intracerebral hemorrhage, which is associated with hypertension, head trauma and premature birth...
  101. doi Global differences in patient characteristics, case management and outcomes in intracerebral hemorrhage: the Factor Seven for Acute Hemorrhagic Stroke (FAST) trial
    Michael C Christensen
    Global Development, Novo Nordisk A S, Bagsvaerd, Denmark
    Cerebrovasc Dis 28:55-64. 2009
    ..This study examines differences in outcomes after ICH in a recent multinational trial, and explores the effect of differences in patient severity and case management for the variations observed...

Research Grants83

  1. CEREBRAL HEMORRHAGE MODEL--MECHANISMS AND TREATMENTS
    Kenneth Wagner; Fiscal Year: 1999
    ..These studies explore new pathophysiologic mechanisms that initiate brain injury from ICH, and derive novel therapeutic approaches to improve outcome by interrupting pathologic sequences before irreversible damage occurs. ..
  2. Regulation of neural cell volume by thrombin receptors
    Tooba Cheema; Fiscal Year: 2006
    ..that activation of thrombin receptors in the brain can exert a neuroprotective role against ischemia or cerebral hemorrhage has recently emerged...
  3. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
    A complication of stroke is cerebral hemorrhage. The heme oxygenase (HO) system, which plays a key role in cellular defense mechanisms, catalyses oxidation of hemoglobin heme to biologically active molecules: bile pigments and CO...
  4. A platelet ligand mimetic for neurothrombotic disorders
    Catherine Woods; Fiscal Year: 2006
    ..There is an urgent medical need for improved therapies for diseases such as stroke, cerebral hemorrhage and cerebral thrombotic complications in disorders such as thrombotic thrombocytopenic purpura (TTP), ..
  5. AbetaPP and Cerebral Vasculopathy
    William Van Nostrand; Fiscal Year: 2006
    ..feature of patients with Alzheimer's disease (AD) and related disorders and is a primary cause of cerebral hemorrhage. The reason as to why cerebrovascular AB deposition leads to loss of vessel wall integrity and hemorrhagic ..
  6. Transgenic Model for Cerebral Amyloid Angiopathy
    William Van Nostrand; Fiscal Year: 2006
    ..is a common pathological feature of patients with Alzheimer's disease (AD) and several related hereditary cerebral hemorrhage with amyloidosis (HCHWA) disorders...
  7. Plasminogen Activation & SK: Structure-Function
    Guy Reed; Fiscal Year: 2009
    ..tenet of the fibrinolytic field by determining whether fibrin-specific Pg activation decreases the risk of cerebral hemorrhage in vivo...
  8. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): Cerebral hemorrhage is the main cause of abnormal cerebral arteriolar constriction resulting in cerebral ischemia that leads to paralysis, mental and physical disabilities, and deaths...
  9. Plasminogen Activation & SK: Structure-Function
    Guy L Reed; Fiscal Year: 2010
    ..tenet of the fibrinolytic field by determining whether fibrin-specific Pg activation decreases the risk of cerebral hemorrhage in vivo...
  10. CEREBRAL HEMORRHAGE MODEL--MECHANISMS AND TREATMENTS
    Kenneth Wagner; Fiscal Year: 1993
    ....
  11. Imaging Study of Combination Thrombolytic Therapy
    George Shaw; Fiscal Year: 2007
    ..There are many contraindications and side effects to this treatment including intra-cerebral hemorrhage (ICH)...
  12. tPA plus MMP inhibition for combination stroke therapy
    ENG LO; Fiscal Year: 2007
    ..for ischemic stroke is the limited time window for effective therapy and the related complications of cerebral hemorrhage and edema...
  13. tPA plus MMP inhibition for combination stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..for ischemic stroke is the limited time window for effective therapy and the related complications of cerebral hemorrhage and edema...
  14. Animal models for cerebral amyloid angiopathy
    Efrat Levy; Fiscal Year: 2006
    A L68Q variant cystatin C forms the amyloid deposited in cerebral vessel walls of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type...
  15. Antihypertensive Treatment in Acute Cerebral Hemorrhage
    Adnan Qureshi; Fiscal Year: 2006
    ..The 3 month functional outcome measured by modified Rankin Scale and Barthel Index will be used to obtain a preliminary estimate of the treatment effect related to the anti-HTN therapy. Time line: Three years. ..