brain ischemia

Summary

Summary: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Top Publications

  1. ncbi Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros
    Harold P Adams
    Stroke 38:1655-711. 2007
  2. doi Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
  3. ncbi Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    Mélanie Lalancette-Hébert
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada G1V 4G2
    J Neurosci 27:2596-605. 2007
  4. pmc Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
  5. pmc The immunology of stroke: from mechanisms to translation
    Costantino Iadecola
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA
    Nat Med 17:796-808. 2011
  6. pmc Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Leukoc Biol 87:779-89. 2010
  7. pmc Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007
  8. ncbi A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
  9. doi Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
  10. doi Apoptotic mechanisms after cerebral ischemia
    Brad R S Broughton
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Stroke 40:e331-9. 2009

Detail Information

Publications313 found, 100 shown here

  1. ncbi Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros
    Harold P Adams
    Stroke 38:1655-711. 2007
    ..The intended audience is physicians and other emergency healthcare providers who treat patients within the first 48 hours after stroke. In addition, information for healthcare policy makers is included...
  2. doi Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
    ..We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke...
  3. ncbi Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    Mélanie Lalancette-Hébert
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada G1V 4G2
    J Neurosci 27:2596-605. 2007
    ....
  4. pmc Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
    ..Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success...
  5. pmc The immunology of stroke: from mechanisms to translation
    Costantino Iadecola
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA
    Nat Med 17:796-808. 2011
    ....
  6. pmc Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Leukoc Biol 87:779-89. 2010
    ..We discuss how these cells contribute to ischemic brain injury and highlight certain recent findings and currently unanswered questions about inflammatory cells in the pathophysiology of ischemic stroke...
  7. pmc Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007
    ..Our findings establish a proapoptotic signaling pathway for TLR2 and -4 in neurons that may render them vulnerable to ischemic death...
  8. ncbi A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
    ..These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury...
  9. doi Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
    ..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
  10. doi Apoptotic mechanisms after cerebral ischemia
    Brad R S Broughton
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Stroke 40:e331-9. 2009
    ..Traditionally, cell death after cerebral ischemia was considered to be exclusively necrotic in nature, but research over the past decade has revealed that after a stroke, many neurons in the ischemic penumbra will undergo apoptosis...
  11. ncbi Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats
    J Chen
    Departments of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    Stroke 32:2682-8. 2001
    ..01) compared with normal brain tissue. CONCLUSIONS: Intravenously administered HUCBC enter brain, survive, migrate, and improve functional recovery after stroke. HUCBC transplantation may provide a cell source to treat stroke...
  12. ncbi The impact of recanalization on ischemic stroke outcome: a meta-analysis
    Joung Ho Rha
    Department of Neurology, Inha University Hospital, Incheon, Korea
    Stroke 38:967-73. 2007
    ....
  13. pmc Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use
    Ulrich Dirnagl
    Department of Neurology, Center for Stroke Research, Charite Universitatsmedizin Berlin, Chariteplatz, D 10098, Berlin, Germany
    Lancet Neurol 8:398-412. 2009
    ..We also discuss whether preconditioning and tolerance occur naturally in the brain and assess the most promising candidate strategies that are being investigated...
  14. doi Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial
    Wade S Smith
    Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0114, USA
    Stroke 39:1205-12. 2008
    ..Enhancements in embolectomy device design may improve recanalization rates...
  15. doi Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 41:2391-5. 2010
    ..The second issue is the variability and overlap of terms used to describe each phenomenon. This makes comparisons among studies difficult...
  16. ncbi Reactive oxygen radicals in signaling and damage in the ischemic brain
    P H Chan
    Department of Neurosurgery, Stanford University School of Medicine, California 94205-5487, USA
    J Cereb Blood Flow Metab 21:2-14. 2001
    ..Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury...
  17. ncbi Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Japan
    Cell 110:429-41. 2002
    ..These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases...
  18. doi Enhanced detection of paroxysmal atrial fibrillation by early and prolonged continuous holter monitoring in patients with cerebral ischemia presenting in sinus rhythm
    Raoul Stahrenberg
    Department of Cardiology and Pneumology, Universitatsmedizin Gottingen, 37075 Gottingen, Germany
    Stroke 41:2884-8. 2010
    ..Early initiation and prolongation of continuous Holter monitoring may improve diagnostic yield compared with the standard of care including a 24-hour Holter recording...
  19. ncbi Early release of HMGB-1 from neurons after the onset of brain ischemia
    Jianhua Qiu
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 28:927-38. 2008
    ..high-mobility group box 1 (HMGB-1) promotes inflammation in sepsis, but little is known about its role in brain ischemia-induced inflammation...
  20. ncbi Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
    ..Disrupted TJPs previously seen in endothelial cells appeared in the surrounding astrocytes. Our results provide direct evidence that MMPs open the BBB by degrading TJPs and that an MMP inhibitor prevents degradation of the TJPs by MMPs...
  21. pmc Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
    H J Marti
    Department of Molecular Cell Biology, the Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Am J Pathol 156:965-76. 2000
    ..Exogenous support of this natural protective mechanism might lead to enhanced survival after stroke...
  22. ncbi Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    A Furlan
    Cerebrovascular Center, Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
    JAMA 282:2003-11. 1999
    ..Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed...
  23. ncbi Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Counc
    Larry B Goldstein
    Stroke 37:1583-633. 2006
    ..This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk...
  24. pmc Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values
    David Brea
    Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 31:1424-31. 2011
    ..In conclusion, TLR2 and TLR4 are associated to outcome in stroke patients and TLR2/4 or their endogenous ligands, cFN/HSP60 could be new therapeutic targets for ischemic stroke...
  25. pmc Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequency
    Fei Zhou
    Shanghai Research Center for Acupuncture and Meridians, Shanghai, China
    J Appl Physiol (1985) 111:1877-87. 2011
    ..Our findings have far-reaching impacts on the prevention and treatment of ischemic encephalopathy, and the optimized EA parameters may potentially be a useful clue for the clinical application of EA...
  26. pmc Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroinflammation 8:164. 2011
    ..It is not understood whether systemic inflammatory challenges impair outcome after stroke by increasing brain injury only or whether they have direct effects on brain oedema, cerebrovascular inflammation and blood-brain barrier damage...
  27. ncbi Protective role of reactive astrocytes in brain ischemia
    Lizhen Li
    Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology at Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 28:468-81. 2008
    Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due to the absence of suitable experimental models...
  28. pmc Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
    Carlo Perego
    Laboratory of Inflammation and Nervous System Diseases, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Neuroinflammation 8:174. 2011
    ....
  29. ncbi Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros
    Harold P Adams
    University of Iowa Carver College of Medicine, USA
    Circulation 115:e478-534. 2007
    ..The intended audience is physicians and other emergency healthcare providers who treat patients within the first 48 hours after stroke. In addition, information for healthcare policy makers is included...
  30. pmc Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia
    Bolanle M Famakin
    Stroke Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Rm 5B06, MSC 1401, Bethesda, MD 20892 1401, USA
    Brain Res 1388:148-56. 2011
    ..9±8.4mm(3). These findings show that disruption of MyD88 or TRIF signaling does not confer protection in brain ischemia and suggests the possibility of additional or alternate downstream adaptors during TLR signaling in cerebral ..
  31. doi Neuroprotective effects of ischemic postconditioning on global brain ischemia in rats through upregulation of hippocampal glutamine synthetase
    Weiqiao Zhang
    Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Road, Pudong New District, Shanghai 200127, China
    J Clin Neurosci 18:685-9. 2011
    ..05) GS expression compared with both the sham and ischemia-reperfusion groups, suggesting that upregulation of GS expression after ischemia constitutes a neuroprotective mechanism...
  32. doi The neurovascular unit, matrix proteases, and innate inflammation
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 1207:46-9. 2010
    ..Recent experimental work suggests specific cell sources for MMP-9 generation and for matrix proteases from four distinct families that could impact neurovascular unit integrity...
  33. ncbi Inflammation in ischemic brain injury: timing is important
    Jasna Kriz
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Boulevard Laurier, Quebec, QC, G1V4G2, Canada
    Crit Rev Neurobiol 18:145-57. 2006
    ..There is increasing evidence that post-ischemic inflammation plays an important role in brain ischemia. However, whether inflammatory processes are deleterious or beneficial to recovery is presently a matter of ..
  34. ncbi High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo
    G Faraco
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    J Neurochem 103:590-603. 2007
    ..Together, data underscore the neuropathological role of nuclear HMGB1, and point to the protein as a mediator of post-ischemic brain damage...
  35. pmc A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
    Daniel F Gudbjartsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:876-8. 2009
    ..21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples...
  36. pmc Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia
    E Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Neuroscience 158:983-94. 2009
    ..Inhibitors of metalloproteinases are available, but balancing the beneficial and detrimental effects of these agents remains a challenge...
  37. ncbi Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Lancet 352:1245-51. 1998
    ..We have assessed the safety and efficacy of intravenous thrombolysis with alteplase (0.9 mg/kg bodyweight) within 6 h of stroke onset...
  38. ncbi Cerebral ischemia: models, methods and outcomes
    Konstantin Alexander Hossmann
    Max Planck Institute for Neurological Research, Cologne, Germany
    Neuropharmacology 55:257-70. 2008
    Experimental research into brain ischemia contributes substantially to the understanding of ischemic injury mechanisms but suffers from its limited relevance for clinical treatment strategies...
  39. ncbi Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons
    Toru Yamashita
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Neurochem 94:459-68. 2005
    ..These results suggest that endogenous IL-6 plays a critical role in preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia and that its role may be mediated by Stat3 activation...
  40. ncbi Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
    C Iadecola
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 17:9157-64. 1997
    ..iNOS inhibition may provide a novel therapeutic strategy targeted specifically at the secondary progression of ischemic brain injury...
  41. ncbi Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94
    M Asahi
    Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Charlestown 02129, USA
    J Cereb Blood Flow Metab 20:1681-9. 2000
    ..These data demonstrate that MMP-9 plays a deleterious role in the development of brain injury after focal ischemia...
  42. ncbi Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
    Ya Dan Wen
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 4:762-9. 2008
    ..These results demonstrate that ischemic insult activates autophagy and an autophagic mechanism may contribute to ischemic neuronal injury. Thus, autophagy may be a potential target for developing a novel therapy for stroke...
  43. pmc Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia
    David W Howells
    National Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Melbourne, Victoria, Australia
    J Cereb Blood Flow Metab 30:1412-31. 2010
    ..The aim is to provide, for novice and expert alike, an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research...
  44. ncbi Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats
    Jieli Chen
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Mich, USA
    Circ Res 92:692-9. 2003
    ..These data suggest that treatment of stroke with hMSCs enhances angiogenesis in the host brain and hMSC-enhanced angiogenesis is mediated by increases in levels of endogenous rat VEGF and VEGFR2...
  45. doi Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds
    Krishna A Dani
    Department of Neurology, Institute of Neurological Sciences, University of Glasgow Southern General Hospital, Glasgow, Scotland
    Ann Neurol 70:384-401. 2011
    ..The optimum perfusion values to identify tissue at risk of infarction in acute stroke are unclear. We systematically reviewed CT and MR perfusion imaging in acute ischemic stroke...
  46. ncbi Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Cereb Blood Flow Metab 29:464-79. 2009
    ..Taken together, the information suggests that IL-6 plays a double role in cerebral ischemia, as an inflammatory mediator during the acute phase and as a neurotrophic mediator between the subacute and prolonged phases...
  47. doi The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke. The Johann Jacob Wepfer award 2011
    Wolf Dieter Heiss
    Max Planck Institute for Neurological Research, Cologne, Germany
    Cerebrovasc Dis 32:307-20. 2011
    ..As long as a validation of the mismatch selection paradigm is lacking, its use as a surrogate marker of outcome is limited...
  48. doi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
    ..The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury...
  49. ncbi Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke
    Randall T Higashida
    University of California, San Francisco Medical Center, Department of Radiology, 505 Parnassus Ave, Rm L 352, San Francisco, CA 94143 0628, USA
    Stroke 34:e109-37. 2003
    ....
  50. ncbi Rapid tolerance to focal cerebral ischemia in rats is induced by preconditioning with electroacupuncture: window of protection and the role of adenosine
    Qiang Wang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 Shaanxi, China
    Neurosci Lett 381:158-62. 2005
    ..The rapid ischemic tolerance appears at 2 h (but not at 0.5, 1, or 3 h) after preconditioning, and is possibly mediated through an adenosine A1 receptor-related mechanism...
  51. pmc Microglial involvement in neuroplastic changes following focal brain ischemia in rats
    Alexandre Madinier
    Unité INSERM U887 Motricité Plasticité, Dijon, France
    PLoS ONE 4:e8101. 2009
    ....
  52. ncbi Timing for fever-related brain damage in acute ischemic stroke
    J Castillo
    Department of Neurology, Complexo Hospitalario Universitario de Santiago Hospital Xeral de Galicia, Barcelona, Spain
    Stroke 29:2455-60. 1998
    ..The aim of this study was to determine the prognostic value of body temperature measured at different times after onset of stroke...
  53. ncbi Dual role of tumor necrosis factor alpha in brain injury
    E Shohami
    Department of Pharmacology, Hebrew University School of Pharmacy, Jerusalem, Israel
    Cytokine Growth Factor Rev 10:119-30. 1999
    ..It is suggested that the appropriate context of mediators, at any given time after brain injury may well determine whether the effect of TNF alpha is protective or toxic...
  54. ncbi Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis
    Wolf Rüdiger Schäbitz
    Department of Neurology, University of Munster, Germany
    Stroke 38:2165-72. 2007
    ..Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis...
  55. ncbi Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation
    A Denes
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Brain Behav Immun 24:708-23. 2010
    ..However, a greater understanding of the contribution of inflammation to CI is still required, and this review highlights some of the key mechanism that may offer future therapeutic targets...
  56. ncbi Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia
    Hideo Shichinohe
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Brain Res 1029:200-6. 2004
    ..These findings suggest that Edaravone salvages the boundary zone of infarct by scavenging reactive oxygen species especially in the neurons during permanent focal cerebral ischemia...
  57. doi Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
    K Hyakkoku
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    Neuroscience 171:258-67. 2010
    ..These data suggest that TLR4 knockout, but not TLR3 or TLR9 knockout, may play a neuroprotective role in ischemic brain injury induced by MCAO in mice...
  58. ncbi Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, California 94305, USA
    J Neurosci 25:9794-806. 2005
    ..Hypothermia may protect from ischemic damage in part by preserving Akt activity and attenuating the apoptotic effects of PTEN, PDK1, and FKHR...
  59. ncbi Measurement of brain temperature with magnetic resonance spectroscopy in acute ischemic stroke
    Bartosz Karaszewski
    Department of Neurology of Adults, Medical University of Gdansk, Gdansk, Poland
    Ann Neurol 60:438-46. 2006
    ..We used magnetic resonance spectroscopic imaging (water-to-N-acetylaspartate frequency shift) to measure cerebral temperature noninvasively in stroke patients...
  60. pmc Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury
    Susan L Stevens
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 31:8456-63. 2011
    ..of the TLR4 ligand LPS or the TLR9 ligand unmethylated CpG oligodeoxynucleotide before transient brain ischemia in mice confers substantial protection against ischemic damage...
  61. ncbi Intracerebroventricular injection of microglia protects against focal brain ischemia
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 94:203-6. 2004
    ..At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion...
  62. ncbi A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia
    Joanna Dluzniewska
    Molecular Biology Unit, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    FASEB J 19:1896-8. 2005
    ..In vivo, in a gerbil model of transient brain ischemia, treatment with the synthetic MGF C-terminal peptide provided very significant protection to the vulnerable ..
  63. ncbi JNK inhibition and inflammation after cerebral ischemia
    Corinne Benakis
    Department of Neurology, University Hospital CHUV, Lausanne, Switzerland
    Brain Behav Immun 24:800-11. 2010
    ..In contrast, in vitro data show an indirect effect of D-JNKI1 on the modulation of microglial activation...
  64. pmc Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage
    Jens P Dreier
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Brain 132:1866-81. 2009
    ....
  65. ncbi Subarachnoid haemorrhage
    Jan van Gijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
    Lancet 369:306-18. 2007
    ..Hydrocephalus might cause gradual obtundation in the first few hours or days; it can be treated by lumbar puncture or ventricular drainage, dependent on the site of obstruction...
  66. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  67. ncbi Role of inflammatory markers in brain ischemia
    Manuel Rodríguez-Yáñez
    Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Curr Opin Neurol 21:353-7. 2008
    Inflammatory mechanisms play an important role in the risk of stroke and during the acute phase of brain ischemia, which contributes to functional outcome of patients...
  68. pmc Therapeutic hypothermia for brain ischemia: where have we come and where do we go?
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, CA 94121, USA
    Stroke 41:S72-4. 2010
    ..We review the state of therapeutic hypothermia in ischemic and hemorrhagic stroke and provide an outlook for its role in stroke therapy...
  69. ncbi Role of T lymphocytes and interferon-gamma in ischemic stroke
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Circulation 113:2105-12. 2006
    ....
  70. ncbi Exciting, radical, suicidal: how brain cells die after stroke
    Eng H Lo
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, MGH East 149 2401, Charlestown, MA 02129, USA
    Stroke 36:189-92. 2005
  71. ncbi Protective effect of exogenous administration of alpha-tocopherol in middle cerebral artery occlusion model of cerebral ischemia in rats
    Geeta Chaudhary
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India
    Fundam Clin Pharmacol 17:703-7. 2003
    ..The results demonstrate that exogenous administration of alpha-tocopherol is able to reduce the neuronal damage caused during ischemia-reperfusion, which can be attributed to its antioxidant activity...
  72. ncbi Inflammatory cytokines in acute ischemic stroke
    Antonino Tuttolomondo
    Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Italy
    Curr Pharm Des 14:3574-89. 2008
    ....
  73. ncbi Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury
    J Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Neurosci 21:5272-80. 2001
    ....
  74. pmc Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    D B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 98:1952-7. 2001
    ..Our discovery that ER alpha mediates protection of the brain carries far-reaching implications for the selective targeting of ERs in the treatment and prevention of neural dysfunction associated with normal aging or brain injury...
  75. ncbi Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery
    S B Frost
    Center on Aging, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurophysiol 89:3205-14. 2003
    ..Reorganization in intact tissue may provide a neural substrate for adaptive motor behavior and play a critical role in postinjury recovery of function...
  76. ncbi Apoptotic and antiapoptotic mechanisms in stroke
    M P Mattson
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224 6825, USA
    Cell Tissue Res 301:173-87. 2000
    ..Interestingly, recent studies suggest novel dietary approaches (e.g., food restriction and supplementation with antioxidants) that may reduce brain damage following stroke...
  77. ncbi Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Mol Cell Neurosci 24:171-89. 2003
    ..These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery...
  78. ncbi Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke
    W M Clark
    Oregon Stroke Center, Portland 97201, USA
    JAMA 282:2019-26. 1999
    ..This restricts the number of patients who can be treated, since most stroke patients present more than 3 hours after symptom onset...
  79. ncbi Neuroprotective properties of statins in cerebral ischemia and stroke
    C J Vaughan
    Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, NY 10021, USA
    Stroke 30:1969-73. 1999
    ..In this article, we review the emerging evidence that statins have beneficial effects within the cerebral circulation and brain parenchyma during ischemic stroke and reperfusion...
  80. pmc Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats
    Yu Hasegawa
    Department of Physiology, Loma Linda University School of Medicine, Loma Linda, Calif 92354, USA
    Stroke 41:368-74. 2010
    ..FTY720 is a known sphingosine 1-phosphate receptor agonist. In the present study, we investigated the neuroprotective effect of postischemic administration of FTY720 in rats with 2 hours transient middle cerebral artery occlusion (MCAO)...
  81. doi The poor outcome of ischemic stroke in very old people: a cohort study of its determinants
    Licia Denti
    Geriatric and Rehabilitation Department, University Hospital of Parma, Parma, Italy
    J Am Geriatr Soc 58:12-7. 2010
    ..To assess how much of the excess risk of poor outcome from stroke in people aged 80 and older aging per se explains, independent of other prognostic determinants...
  82. doi Hemispheric hypoperfusion in postictal paresis mimics early brain ischemia
    Sven Rupprecht
    Department of Neurology, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Epilepsy Res 89:355-9. 2010
    ..Further investigations are warranted to clarify the role of cerebrovascular dysfunction in the pathophysiology of postictal paresis...
  83. ncbi Matrix metalloproteinases and free radicals in cerebral ischemia
    K Jian Liu
    College of Pharmacy, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Free Radic Biol Med 39:71-80. 2005
    ..Understanding the relationship between proteases and free radicals in cerebral ischemia is critical for the design of therapeutic agents aimed at controlling cell death in ischemic tissues...
  84. pmc Experimental and preliminary clinical evidence of an ischemic zone with prolonged negative DC shifts surrounded by a normally perfused tissue belt with persistent electrocorticographic depression
    Ana I Oliveira-Ferreira
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 30:1504-19. 2010
    ..These preliminary results suggest that the ischemic zone in rat and human cortex is surrounded by a normally perfused belt with persistently reduced synaptic activity during the acute injury phase...
  85. ncbi Efficacy of rehabilitative experience declines with time after focal ischemic brain injury
    Jeff Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s Campus, Newfoundland, Canada A1B 3V6
    J Neurosci 24:1245-54. 2004
    ..These findings have important implications for rehabilitation of stroke patients, many of whom experience considerable delays before therapy is initiated...
  86. pmc The "golden hour" and acute brain ischemia: presenting features and lytic therapy in >30,000 patients arriving within 60 minutes of stroke onset
    Jeffrey L Saver
    Department of Neurology, University of California, Los Angeles, Calif 90095, USA
    Stroke 41:1431-9. 2010
    The benefit of intravenous thrombolytic therapy in acute brain ischemia is strongly time dependent.
  87. ncbi Stroke-induced immunodepression: experimental evidence and clinical relevance
    Ulrich Dirnagl
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Stroke 38:770-3. 2007
    ..Nevertheless, clinical evidence is emerging demonstrating that stroke-induced immunodepression in humans not only exists, but has very similar features to those characterized in rodent experiments...
  88. pmc Recurrent spontaneous spreading depolarizations facilitate acute dendritic injury in the ischemic penumbra
    W Christopher Risher
    Graduate Program in Neuroscience, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 30:9859-68. 2010
    ..We propose that metabolic stress resulting from recurring SDs facilitates acute injury at the level of dendrites and dendritic spines in metabolically compromised tissue, expediting penumbral recruitment into the ischemic core...
  89. pmc Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival
    Kuniyasu Niizuma
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5487, USA
    J Neurochem 109:133-8. 2009
    ....
  90. pmc Evidence for stroke-induced neurogenesis in the human brain
    Kunlin Jin
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:13198-202. 2006
    ..These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy...
  91. ncbi Recombinant C1 inhibitor in brain ischemic injury
    Raffaella Gesuete
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Ann Neurol 66:332-42. 2009
    ..We have explored the efficacy and the therapeutic window of the recently available human recombinant (rh) C1-INH on ischemic brain injury and investigated its mechanism of action in comparison with that of plasma-derived (pd) C1-INH...
  92. ncbi Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study
    Rolf T Urbanus
    Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet Neurol 8:998-1005. 2009
    ....
  93. pmc Primary prevention of stroke by healthy lifestyle
    Stephanie E Chiuve
    Harvard School of Public Health, Department of Nutrition, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 118:947-54. 2008
    ..The combination of healthy lifestyle factors is associated with lower risk of coronary heart disease, diabetes, and total cardiovascular disease. Little is known about the impact of multiple lifestyle factors on the risk of stroke...
  94. ncbi Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Stroke 34:975-81. 2003
    ..Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs)...
  95. doi Hospitalizations for incident stroke in Shunde District, Foshan, South China
    Wenbin Liang
    School of Public Health, Curtin University of Technology, Perth, WA, Australia
    Neuroepidemiology 30:101-4. 2008
    ..However, CT scan and MRI were not widely used in China until the middle 1990s. We estimate the stroke incidence based on stroke hospitalizations in Shunde District, Foshan, south China...
  96. pmc Combination therapy with hypothermia for treatment of cerebral ischemia
    Xian N Tang
    Department of Neurology, University of California, San Francisco and San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
    J Neurotrauma 26:325-31. 2009
    ..The experimental data nevertheless seem to favor a combinatorial approach. Thus, in order to apply hypothermia to a broader range of patients, combination strategies should be further investigated...
  97. ncbi Transcranial Doppler for predicting delayed cerebral ischemia after subarachnoid hemorrhage
    Emmanuel Carrera
    Neurological Intensive Care Unit, Departments of Neurology and Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 65:316-23; discussion 323-4. 2009
    ..We sought to determine the prognostic utility of serial TCD examination after SAH...
  98. ncbi Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture
    Myron D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
    Stroke 34:214-23. 2003
    ..This presentation first highlights insights into the ischemic penumbra enabled by a multimodal experimental approach; second, discusses gene expression in ischemia; and third, confronts the challenges of neuroprotectant therapy...
  99. doi Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic
    Manuel Yepes
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Trends Neurosci 32:48-55. 2009
    ..Here, the best studied pathways of tPA neurotoxicity are discussed along with future directions for a safer use of tPA as a thrombolytic agent in the setting of acute ischemic stroke...
  100. ncbi The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:2849-58. 2009
    ..Herein, we characterize the impact of 3 ischemia models on systemic immunological and microbiological parameters...
  101. ncbi Inflammation and infection in clinical stroke
    Hedley C A Emsley
    University of Manchester and Stroke Services, Clinical Sciences Building, Hope Hospital, Eccles Old Road, Salford, M6 8HD, U K
    J Cereb Blood Flow Metab 22:1399-419. 2002
    ..Newer approaches have included antimicrobial and antileukocyte strategies. One of the most promising avenues may be the use of cytokine antagonism, for example, interleukin-1 receptor antagonist...

Research Grants133 found, 100 shown here

  1. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 2002
    ..P-glycoprotein and the organic acid transporter both play a major role in limiting the access of some drugs to the brain. ..
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. Age-dependent microglial responses in hypoxia-ischemia
    PETER A FERRAZZANO; Fiscal Year: 2013
    ....
  4. Stress Proteins in Brain Cell Injury
    Rona G Giffard; Fiscal Year: 2013
    ..Overall this proposal exams a novel hypothesis: that miRNAs act as master regulators of chaperones and BCL2 family members influencing Ca2+ homeostasis, mitochondria-ER crosstalk, and outcome after cerebral ischemia. ..
  5. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..If successful, the findings of these exploratory studies will be used in near future translational studies designed to optimize tVNS treatment for acute ischemic stroke in humans. ..
  6. CaMKII in global cerebral ischemia
    Paco S Herson; Fiscal Year: 2013
    ....
  7. Elevated Zinc in Ischemia and reperfusion
    Yang V Li; Fiscal Year: 2013
    ....
  8. Development of Potent/Selective Lipoxygenase Therapeutics Against Stroke Injury
    Theodore R Holman; Fiscal Year: 2013
    ..Considering that our "validated hit" manifests a 30% reduction in infarct size, we are confident these studies will discover a 12/15- LOX inhibitor as an effective therapeutic against stroke damage. ..
  9. MicroRNA-Mediated Translation Initiation Arrest In Ischemic Brain
    Julie Anne Saugstad; Fiscal Year: 2013
    ..Our findings could also lead to development of novel stroke therapies based on miRNAs and their potential for regulating translation initiation in ischemic brain. ..
  10. Targeting the Pial Collateral Circulation for Mitigation of Cerebral Ischemia
    James E Faber; Fiscal Year: 2013
    ..Identifying this major allele that when polymorphic impairs collateral formation may also provide a genetic marker for use in these same patient groups. ..
  11. PAR-1 Signaling and HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
    ..Moreover, newly developed orally available PAR-1 antagonists that are now in clinical trials for coronary artery disease might be considered for treatment of the same. ..
  12. Nitrite based neuroprotection after cardiac arrest
    Cameron Dezfulian; Fiscal Year: 2013
    ..NIH-funded neuroscientist who studies mechanisms of neuroprotection and mitochondrial dysfunction after brain ischemia. Dr. Dezfulian will be co-mentored by Dr...
  13. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN FADEN; Fiscal Year: 2009
    ....
  14. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN FADEN; Fiscal Year: 2009
    ....
  15. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ....
  16. Noninvasive, Optoacoustic Monitoring of Cerebral Circulation in Preterm Neonates
    GRAHAM RANDALL; Fiscal Year: 2013
    ..Specific Aim 3. Preliminarily establish in vivo in neonates the range of SSSSO2 to be expected in infants of varying body weight (10-12 LBW neonates and 10-12 VLBW neonates). ..
  17. Mechanisms of early brain injury after subarachnoid hemmorrhage
    Guohua Xi; Fiscal Year: 2013
    ..The purpose of our project is to examine mechanisms of early brain injury after SAH. Data from the proposed studies may lead to new therapies for SAH. The long-term goal of our studies is to limit brain damage in SAH patients. ..
  18. US-China Collaborative Research on Stroke Imaging
    Jinyuan Zhou; Fiscal Year: 2013
    ..are: (i) to assess the characteristics and spatio-temporal evolution of perfusion/pH/diffusion deficits in rat brain ischemia/reperfusion models;and (ii) to determine the radiologic characteristics and clinical values of pH imaging of ..
  19. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..Our findings will be relevant to the development of novel therapeutic strategies targeting pro- inflammatory pathways in AD. ..
  20. Restoration of Endoplasmic Reticulum Function in Experimental Stroke
    Wulf Paschen; Fiscal Year: 2013
    ....
  21. Mu Center for Botanical Interaction Studies
    Dennis B Lubahn; Fiscal Year: 2013
    ....
  22. PGE2 EP1 and EP3 receptors as therapeutic targets in intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2013
    ..This proof-of-concept information is required to plan more detailed preclinical assessment of selective EP1 and EP3 receptor antagonists in ICH. ..
  23. FASEB SRC on The Biology of Calpains in Health and Disease
    James W Geddes; Fiscal Year: 2013
    ..The proposed program will provide the forum by which the momentum in this field may be maintained. ..
  24. NEUROCHEMISTRY OF CEREBRAL ISCHEMIA AND REPERFUSION
    George Newman; Fiscal Year: 1993
    ....
  25. Role of Nrf2 in Ischemic Preconditioning-Induced Neuroprotection
    Srinivasan V Narayanan; Fiscal Year: 2013
    ..These proposed studies will enhance our understanding of IPC, and how Nrf2 can be exploited to develop novel prophylactic therapy for the treatment of cerebral ischemia. ..
  26. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O'DONNELL; Fiscal Year: 2013
    ..We will also assess the efficacy of NKCC, NHE and NBC inhibitors for reduction of edema when administered after the onset of ischemia. ..
  27. The Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain Injury
    Wenhan Chang; Fiscal Year: 2013
    ..The successful completion of the study will establish a novel pathway that produces ischemia-induced neuronal injury and will develop a new therapy for treating diseases due to ischemic brain injury. ..
  28. Role of SUMO Conjugation in Ischemia: Significance, Mechanisms and Pathways
    Wulf Paschen; Fiscal Year: 2013
    ....
  29. Sulfonylurea receptor 1 (SUR1) - A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2013
    ..called the SUR1/TRPM4 channel) plays a critical role in edema, lesion expansion and cell death following brain ischemia. New preliminary data for this proposal, obtained with a severe ischemia/reperfusion models (6-h MCAo/48 h ..
  30. Microglial Signal Transduction in Fever and Vasospasm after Subarachnoid Hemorrha
    Khalid A Hanafy; Fiscal Year: 2013
    ..We are confident that Dr. Hanafy has the tools to complete his project as outlined and hope he will become a successful NIH funded investigator. ..
  31. Mitochondrial Integrity Regulates Cerebral Reperfusion Injury
    THOMAS HUDSON SANDERSON; Fiscal Year: 2013
    ..We hypothesize that, following brain ischemia, mitochondrial dynamics defaults to increased mitochondrial fission as a result of impaired fusion, thus ..
  32. Early Biomarkers in Neonatal Brain Injury
    Sonia L Bonifacio; Fiscal Year: 2013
    ....
  33. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
    ....
  34. POINT: Platelet-Oriented Inhibition in New TIA
    Yuko Y Palesch; Fiscal Year: 2013
    ..If the trial is positive, treatment with clopidogrel could reduce the stroke burden in the US and substantially reduce costs of care. ..
  35. POINT: Platelet-Oriented Inhibition in New TIA
    Yuko Y Palesch; Fiscal Year: 2013
    ..If the trial is positive, treatment with clopidogrel could reduce the stroke burden in the US and substantially reduce costs of care. ..
  36. Atrial Fibrillation Precursors May Be Novel Stroke Risk Factors
    Hooman Kamel; Fiscal Year: 2013
    ..abstract_text> ..
  37. Integrative Genomics of Stroke
    Rose Du; Fiscal Year: 2013
    ..This project uses a mouse model of stroke to examine the genetic basis of stroke susceptibility. This will be accomplished via computational and bioinformatics tools together with the emerging genetics resources. ..
  38. The Role of CaMK Cascade in Stroke
    Jun Li; Fiscal Year: 2013
    ..These studies represent the first steps in improving our understanding of the endogenous signaling pathways that are activated by calcium in the ischemic brain. ..
  39. Restricted diet and adenosine receptor activation: Therapy for brain ischemia
    Kelly L Drew; Fiscal Year: 2012
    ..The present research explores mechanisms used naturally in hibernating animals to suppress metabolism and the potential clinical utility of these mechanisms as prophylactic treatment for CA. ..
  40. The Immunoinhibitory Role of CD200-CD200R1 Signaling in Experimental Stroke
    Rodney Ritzel; Fiscal Year: 2013
    ....
  41. Epigenomics of Patient Outcomes after Aneurysmal SAH
    Yvette Conley; Fiscal Year: 2013
    ....
  42. Pre-clinical Development of a Context-Dependent NMADR Neuroprotectant for Treatme
    SCOTT JAMES MYERS; Fiscal Year: 2013
    ....
  43. ABetaPP Influences Cerebral Thrombosis
    William E Van Nostrand; Fiscal Year: 2013
    ....
  44. Mild Cognitive Impairment and Obstructive Sleep Apnea
    Kathy Culpepper Richards; Fiscal Year: 2013
    ..Additional potential study benefits are increased understanding of the physiological mechanisms for cognitive decline in oaMCI and OSA, and the characteristics of those most likely to benefit from this treatment. ..
  45. ASICs and increased ischemic brain injury in diabetic condition
    Zhigang Xiong; Fiscal Year: 2013
    ..during ischemia based on the following arguments and preliminary data: (1) Acidosis is a common feature of brain ischemia particularly in diabetic patients. Brain pH drops to 6...
  46. TWEAK-Induced Neuroinflammation and Cerebral Edema
    MANUEL SALVADOR YEPES; Fiscal Year: 2011
    ..Thus, if successful, the studies proposed in this application may lead to a decrease in the morbility and mortality among USA Veterans. ..
  47. Microscale Oxygenation Mapping During Stroke
    Andrew K Dunn; Fiscal Year: 2013
    ..Finally, we will quantify the relationship between oxygen levels surrounding individual dendrites and morphological changes in these dendrites during both acute and chronic ischemia. ..
  48. Modeling of Collateral Perfusion in the Ischemic Brain
    DAVID SIGMUND LIEBESKIND; Fiscal Year: 2013
    ..and provision of mentoring opportunities, a tangible resulting product will be a software tool to enhance prediction of tissue fate and neurological outcomes in acute stroke across diverse causes of brain ischemia.
  49. CYP 450-mediated CBF Dysregulation and Neurotoxicity in Pediatric Cardiac Arrest
    Mioara D Manole; Fiscal Year: 2013
    ....
  50. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark J Fisher; Fiscal Year: 2013
    ..Part of the novelty of the project is the genuine collaborative multi-PI effort that combines expertise in stroke and Alzheimer's disease, contributing to the high translational significance. ..
  51. Brain regions involved in seasonally dependent A1AR agonist-induced torpor
    Kelly L Drew; Fiscal Year: 2013
    ..Preliminary data suggest that mechanisms used by hibernating mammals to decrease body temperature will translate to non-hibernating species. ..
  52. Constrictor / Mitogen Induced Remodeling of Cerebral Arterioles
    JAY HUMPHREY; Fiscal Year: 2009
    ..This study will be the first to propose and test this new hypothesis as well as a potential means to block this remodeling. ..
  53. Heat shock proteins in brain ischemia and stroke
    Midori A Yenari; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stroke is a common affliction among veterans, and treatments are few. Brain ischemia frequently causes disruption of the blood brain barrier (BBB) leading to brain edema and hemorrhage which can ..
  54. Vascular Mechanisms of Secondary Injury After Traumatic Brain Injury
    Claudia S Robertson; Fiscal Year: 2012
    ..Effect of Erythropoietin on Anemia and Need for Transfusion Project 3. EDHF Following Traumatic Brain Injury Project 4. Neuroprotection of Erythropoietin Signaling in TBI ..
  55. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2012
    ..Overall, this research could facilitate development of a practical novel treatment for acute stroke. ..
  56. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1993
    ....
  57. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1991
    ....
  58. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1992
    ....
  59. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 2000
    ..P-glycoprotein and the organic acid transporter both play a major role in limiting the access of some drugs to the brain. ..
  60. VEGF in Ischemic Neuroprotection, Neurodegeneration and Repair
    DAVID ALAN GREENBERG; Fiscal Year: 2013
    ..to months after stroke, suggesting that endogenous mechanisms exist for limiting and reversing the effects of brain ischemia. These include neuroprotection, which prevents the progression of reversible to irreversible injury, and ..
  61. IL-1 in Protection and Injury
    Sandra J Hewett; Fiscal Year: 2013
    ..to increase GSH levels to reduce oxidative injury), and when appropriate, to employ strategies to reduce its activity to decrease the probability of excitotoxic neuronal injury (i.e. under conditios where glutamate uptake is impaired). ..
  62. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D RICHARD MILNER; Fiscal Year: 2010
    ..If successful, this work could have major impact on the incidence and mortality of ischemic stroke. ..
  63. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 1990
    ..g., viscosity and red cell aggregation) and coagulation. Finally, we will examine the relationship between these hemorheological and pathologic features and the presence of ischemic symptoms related to carotid artery disease...
  64. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D Milner; Fiscal Year: 2009
    ..If successful, this work could have major impact on the incidence and mortality of ischemic stroke. ..
  65. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2007
    ....
  66. Mechanisms and Treatment of CNS Edema
    Carol M Troy; Fiscal Year: 2013
    ..Aim 2: To determine if signaling via p75NTR activates caspase-9 and leads to edema. Aim 3: To determine how caspase-9 cleavage of substrates leads to loss of vascular integrity. ..
  67. In vivo Inhibition of Specific microRNAs to Support Post-Stroke Revascularization
    Tamara Roitbak; Fiscal Year: 2013
    ..We believe that the proposed research is significant because it is expected to lead to the development of novel therapeutic strategies for improving the post-ischemic recovery. ..
  68. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 2001
    ..P-glycoprotein and the organic acid transporter both play a major role in limiting the access of some drugs to the brain. ..
  69. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1990
    ....
  70. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 1999
    ..P-glycoprotein and the organic acid transporter both play a major role in limiting the access of some drugs to the brain. ..
  71. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Brain ischemia results in permanent disability and death for thousands of patients annually...
  72. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence Katz; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Brain ischemia results in permanent disability and death for thousands of patients annually...
  73. CNS INJURY AND EDEMA RESEARCH CENTER
    Pak Chan; Fiscal Year: 2009
    ..We believe these are novel studies that will provide insights into therapeutic opportunities to minimize oxidative stress-associated hemorrhagic transformation in patients who suffer acute ischemic stroke. ..
  74. tPA Neurotoxicity in Hypoxic-Ischemia Encephalopathy
    Chia Yi Kuan; Fiscal Year: 2009
    ..This hypothesis will be tested in tPA-null animals and by administration of anti-tPA/Plasmin agents after neonatal cerebral ischemia-hypoxia. ..
  75. CNS INJURY AND EDEMA RESEARCH CENTER
    Pak Chan; Fiscal Year: 2007
    ..We believe these are novel studies that will provide insights into therapeutic opportunities to minimize oxidative stress-associated hemorrhagic transformation in patients who suffer acute ischemic stroke. ..
  76. CEREBRAL ISCHEMIA--MINIMIZING DAMAGE DURING ANESTHESIA
    David Warner; Fiscal Year: 1993
    ..Because glutamate antagonists provide both cerebral protection and anesthesia, this work may allow an entirely new mechanistic approach for anesthesia to emerge which possesses major neuroprotective properties...
  77. NEUROPROTECTIVE EFFECT OF HEAT STRESS IN CORTICAL NEURON
    BARBARA SNIDER; Fiscal Year: 1999
    ..Understanding the mechanisms of heat stress induced neuroprotection may provide valuable clues into the pathophysiology of ischemia and may help us understand how neurons and glia interact in pathologic conditions. ..
  78. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2004
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  79. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2003
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  80. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2005
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  81. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2002
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  82. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2009
    ..The application's objectives are to explore the feasibility for further clinical trials of combination therapy of estrogen and rtPA for ischemic stroke. ..
  83. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2010
    ..The application's objectives are to explore the feasibility for further clinical trials of combination therapy of estrogen and rtPA for ischemic stroke. ..
  84. Pilot Trial of Bumetanide for Neonatal Seizures
    JANET SUSAN SOUL; Fiscal Year: 2010
    ..The proposed pilot trial will determine the feasibility of a novel trial design to test new drugs to treat seizures in newborns, and will determine the pharmacokinetics and safety of bumetanide in newborns. ..
  85. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2005
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  86. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2003
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  87. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  88. ORNITHINE DECARBOXYLASE AND ISCHEMIC BRAIN EDEMA
    Robert Dempsey; Fiscal Year: 1990
    ..Completion of these studies would greatly extend the understanding of ODC and its effects following cerebral ischemia and would serve as a basis for the possible use of ODC blockade in clinical studies...
  89. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2010
    ..The studies proposed will provide new insight on the mechanism of vascular dementia and identify potential therapeutic target for the prevention of cognitive decline following cerebral ischemia. ..
  90. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2009
    ..The studies proposed will provide new insight on the mechanism of vascular dementia and identify potential therapeutic target for the prevention of cognitive decline following cerebral ischemia. ..
  91. Heat Shock Protein Therapeutics for Stroke
    FRANK R contact SHARP; Fiscal Year: 2010
    ....
  92. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    ..abstract_text> ..
  93. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    ..abstract_text> ..
  94. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2002
    ..abstract_text> ..
  95. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2002
    ..abstract_text> ..
  96. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2002
    ..abstract_text> ..
  97. Mechanisms of Hyperbaric Oxygen Induced Brain Protection
    John H Zhang; Fiscal Year: 2010
    ....
  98. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2001
    ..abstract_text> ..