brain ischemia


Summary: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Articles from Journal RESEARCH

Top Publications

  1. ncbi Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros
    Harold P Adams
    Stroke 38:1655-711. 2007
  2. doi Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
  3. pmc The immunology of stroke: from mechanisms to translation
    Costantino Iadecola
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA
    Nat Med 17:796-808. 2011
  4. ncbi Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats
    J Chen
    Henry Ford Health Sciences Center, Department of Neurology, Detroit, Michigan, USA
    Stroke 32:1005-11. 2001
  5. pmc Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Leukoc Biol 87:779-89. 2010
  6. ncbi Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
  7. pmc Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
  8. doi Apoptotic mechanisms after cerebral ischemia
    Brad R S Broughton
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Stroke 40:e331-9. 2009
  9. ncbi Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    Mélanie Lalancette-Hébert
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada G1V 4G2
    J Neurosci 27:2596-605. 2007
  10. ncbi Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007

Detail Information

Articles from Journal RESEARCH1

Publications346 found, 100 shown here

  1. ncbi Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros
    Harold P Adams
    Stroke 38:1655-711. 2007
    ..The intended audience is physicians and other emergency healthcare providers who treat patients within the first 48 hours after stroke. In addition, information for healthcare policy makers is included...
  2. doi Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
    ..We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke...
  3. pmc The immunology of stroke: from mechanisms to translation
    Costantino Iadecola
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA
    Nat Med 17:796-808. 2011
  4. ncbi Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats
    J Chen
    Henry Ford Health Sciences Center, Department of Neurology, Detroit, Michigan, USA
    Stroke 32:1005-11. 2001
    ..CONCLUSIONS: MSCs delivered to ischemic brain tissue through an intravenous route provide therapeutic benefit after stroke. MSCs may provide a powerful autoplastic therapy for stroke...
  5. pmc Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Leukoc Biol 87:779-89. 2010
    ..We discuss how these cells contribute to ischemic brain injury and highlight certain recent findings and currently unanswered questions about inflammatory cells in the pathophysiology of ischemic stroke...
  6. ncbi Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
    ..Thus, acidosis injures the brain via membrane receptor-based mechanisms with resultant toxicity of [Ca2+]i, disclosing new potential therapeutic targets for stroke...
  7. pmc Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
    ..Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success...
  8. doi Apoptotic mechanisms after cerebral ischemia
    Brad R S Broughton
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Stroke 40:e331-9. 2009
    ..Traditionally, cell death after cerebral ischemia was considered to be exclusively necrotic in nature, but research over the past decade has revealed that after a stroke, many neurons in the ischemic penumbra will undergo apoptosis...
  9. ncbi Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    Mélanie Lalancette-Hébert
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada G1V 4G2
    J Neurosci 27:2596-605. 2007
  10. ncbi Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
    ..Disrupted TJPs previously seen in endothelial cells appeared in the surrounding astrocytes. Our results provide direct evidence that MMPs open the BBB by degrading TJPs and that an MMP inhibitor prevents degradation of the TJPs by MMPs...
  11. pmc VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    Yunjuan Sun
    Buck Institute for Age Research, Novato, California 94945, USA
    J Clin Invest 111:1843-51. 2003
    ..VEGF may, therefore, improve histological and functional outcome from stroke through multiple mechanisms...
  12. ncbi Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia
    Aysan Durukan
    Department of Neurology, Helsinki University Central Hospital, Biomedicum Helsinki, POB 700, Haartmaninkatu 8, 00290 Helsinki, Finland
    Pharmacol Biochem Behav 87:179-97. 2007
    ..In this article, we focus on various rodent animal models, pathogenic mechanisms, and promising therapeutic approaches of ischemic stroke...
  13. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  14. ncbi The impact of recanalization on ischemic stroke outcome: a meta-analysis
    Joung Ho Rha
    Department of Neurology, Inha University Hospital, Incheon, Korea
    Stroke 38:967-73. 2007
  15. ncbi A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
    ..These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury...
  16. pmc Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
    Carlo Perego
    Laboratory of Inflammation and Nervous System Diseases, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Neuroinflammation 8:174. 2011
  17. ncbi Matrix metalloproteinases in neuroinflammation
    Gary A Rosenberg
    Departments of Neurology, Neurosciences, and Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Glia 39:279-91. 2002
    ..MPs have both beneficial and detrimental roles; understanding their expression in various CNS insults will allow for the use of MMP inhibitors in the treatment of neurological disorders...
  18. ncbi Subarachnoid haemorrhage
    Jan van Gijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
    Lancet 369:306-18. 2007
    ..Hydrocephalus might cause gradual obtundation in the first few hours or days; it can be treated by lumbar puncture or ventricular drainage, dependent on the site of obstruction...
  19. ncbi Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats
    J Chen
    Departments of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    Stroke 32:2682-8. 2001
    ..01) compared with normal brain tissue. CONCLUSIONS: Intravenously administered HUCBC enter brain, survive, migrate, and improve functional recovery after stroke. HUCBC transplantation may provide a cell source to treat stroke...
  20. ncbi Reactive oxygen radicals in signaling and damage in the ischemic brain
    P H Chan
    Department of Neurosurgery, Stanford University School of Medicine, California 94205-5487, USA
    J Cereb Blood Flow Metab 21:2-14. 2001
    ..Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury...
  21. ncbi Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros
    Harold P Adams
    University of Iowa Carver College of Medicine, USA
    Circulation 115:e478-534. 2007
    ..The intended audience is physicians and other emergency healthcare providers who treat patients within the first 48 hours after stroke. In addition, information for healthcare policy makers is included...
  22. doi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
    ..The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury...
  23. pmc Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use
    Ulrich Dirnagl
    Department of Neurology, Center for Stroke Research, Charite Universitatsmedizin Berlin, Chariteplatz, D 10098, Berlin, Germany
    Lancet Neurol 8:398-412. 2009
    ..We also discuss whether preconditioning and tolerance occur naturally in the brain and assess the most promising candidate strategies that are being investigated...
  24. doi Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
    ..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
  25. pmc Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:13798-803. 2007
    ..Our findings establish a proapoptotic signaling pathway for TLR2 and -4 in neurons that may render them vulnerable to ischemic death...
  26. doi Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial
    Wade S Smith
    Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0114, USA
    Stroke 39:1205-12. 2008
    ..Enhancements in embolectomy device design may improve recanalization rates...
  27. ncbi Ischemia opens neuronal gap junction hemichannels
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Science 312:924-7. 2006
    ..Both the current and dye flux were blocked by inhibitors of hemichannels. Therefore, hemichannel opening contributes to the profound ionic dysregulation during stroke and may be a ubiquitous component of ischemic neuronal death...
  28. doi Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 41:2391-5. 2010
    ..The second issue is the variability and overlap of terms used to describe each phenomenon. This makes comparisons among studies difficult...
  29. ncbi Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Japan
    Cell 110:429-41. 2002
    ..These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases...
  30. doi The HMGB1 receptor RAGE mediates ischemic brain damage
    Sajjad Muhammad
    Pharmacological Institute, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 28:12023-31. 2008
    ..RAGE deficiency in bone marrow-derived cells significantly reduced the infarct size. Thus, HMGB1-RAGE signaling links necrosis with macrophage activation and may provide a target for anti-inflammatory therapy in stroke...
  31. doi Enhanced detection of paroxysmal atrial fibrillation by early and prolonged continuous holter monitoring in patients with cerebral ischemia presenting in sinus rhythm
    Raoul Stahrenberg
    Department of Cardiology and Pneumology, Universitatsmedizin Gottingen, 37075 Gottingen, Germany
    Stroke 41:2884-8. 2010
    ..Early initiation and prolongation of continuous Holter monitoring may improve diagnostic yield compared with the standard of care including a 24-hour Holter recording...
  32. pmc Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    A L Siren
    Max Planck Institute for Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 98:4044-9. 2001
    ..The neurotrophic actions suggest there may be longer-latency effects as well. Evaluation of EPO, a compound established as clinically safe, as neuroprotective therapy in acute brain injury is further supported...
  33. ncbi Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Lancet 352:1245-51. 1998
    ..We have assessed the safety and efficacy of intravenous thrombolysis with alteplase (0.9 mg/kg bodyweight) within 6 h of stroke onset...
  34. ncbi Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
    Z Huang
    Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129
    Science 265:1883-5. 1994
    ..Hence, neuronal NO production appears to exacerbate acute ischemic injury, whereas vascular NO protects after middle cerebral artery occlusion. The data emphasize the importance of developing selective inhibitors of the neuronal isoform...
  35. pmc Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain
    Robert H Andres
    Department of Neurosurgery, Stanford Stroke Centre, Stanford Institute for Neuro Innovation and Translational Neurosciences, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305 5487, USA
    Brain 134:1777-89. 2011
    ..Thus, we postulate that human neural progenitor cells aid recovery after stroke through secretion of factors that enhance brain repair and plasticity...
  36. pmc Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat
    K Jin
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 98:4710-5. 2001
    ..These results support a role for ischemia-induced neurogenesis in what may be adaptive processes that contribute to recovery after stroke...
  37. ncbi Role of matrix metalloproteinases in delayed cortical responses after stroke
    Bing Qiao Zhao
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, MGH East 149 2401, Charlestown, Massachusetts 02129, USA
    Nat Med 12:441-5. 2006
    ..These data suggest that, contrary to MMP inhibitor therapies for acute stroke, strategies that modulate MMPs may be needed for promoting stroke recovery...
  38. doi Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
    Muge Yemisci
    Department of Neurology, Faculty of Medicine and Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey
    Nat Med 15:1031-7. 2009
    ..Agents that can restore pericyte dysfunction and microvascular patency may increase the success of thrombolytic and neuroprotective treatments...
  39. doi Systemic infection, inflammation and acute ischemic stroke
    B W McColl
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    Neuroscience 158:1049-61. 2009
    ..We discuss potential mechanisms underlying the impact on ischemic brain injury and highlight the implications for stroke prevention, therapy and modeling...
  40. ncbi Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    A Furlan
    Cerebrovascular Center, Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
    JAMA 282:2003-11. 1999
    ..Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed...
  41. ncbi Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Counc
    Larry B Goldstein
    Stroke 37:1583-633. 2006
    ..This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk...
  42. doi Emerging mechanisms of disrupted cellular signaling in brain ischemia
    Michael Tymianski
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Nat Neurosci 14:1369-73. 2011
  43. pmc DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke
    WeiHong Tu
    Department of Neurology and Neuroscience Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Cell 140:222-34. 2010
    ..Thus, DAPK1 physically and functionally interacts with the NMDA receptor NR2B subunit at extrasynaptic sites and this interaction acts as a central mediator for stroke damage...
  44. doi Post-ischemic brain damage: pathophysiology and role of inflammatory mediators
    Diana Amantea
    Department of Pharmacobiology, University of Calabria, Rende CS, Italy
    FEBS J 276:13-26. 2009
    Neuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair...
  45. doi The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease
    Jens P Dreier
    Center for Stroke Research, Department of Experimental Neurology and Neurology, Charite University Medicine Berlin, Berlin, Germany
    Nat Med 17:439-47. 2011
    ..Therapies that target spreading depolarization or the inverse hemodynamic response may potentially treat these neurological conditions...
  46. ncbi A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
    Tiziana Borsello
    Institut de Biologie Cellulaire et de Morphologie, Universite de Lausanne, Rue du Bugnon 9, CH 1005, Switzerland
    Nat Med 9:1180-6. 2003
    ..Protection correlated with prevention of an increase in c-Jun activation and c-Fos transcription. In view of its potency and long therapeutic window, this protease-resistant peptide is a promising neuroprotective agent for stroke...
  47. doi Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke
    Cornelia Weikert
    Department of Epidemiology, German Institute of Human Nutrition, Nuthetal, Germany
    Circulation 118:2555-62. 2008
    ..Circulating fetuin-A levels are elevated in humans with metabolic syndrome and insulin resistance, conditions that are associated with increased risk of cardiovascular disease...
  48. doi Comparison of 30-day mortality models for profiling hospital performance in acute ischemic stroke with vs without adjustment for stroke severity
    Gregg C Fonarow
    Division of Cardiology, University of California, Los Angeles, USA
    JAMA 308:257-64. 2012
  49. pmc Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequency
    Fei Zhou
    Shanghai Research Center for Acupuncture and Meridians, Shanghai, China
    J Appl Physiol (1985) 111:1877-87. 2011
    ..Our findings have far-reaching impacts on the prevention and treatment of ischemic encephalopathy, and the optimized EA parameters may potentially be a useful clue for the clinical application of EA...
  50. pmc Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values
    David Brea
    Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 31:1424-31. 2011
    ..In conclusion, TLR2 and TLR4 are associated to outcome in stroke patients and TLR2/4 or their endogenous ligands, cFN/HSP60 could be new therapeutic targets for ischemic stroke...
  51. pmc Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroinflammation 8:164. 2011
    ..It is not understood whether systemic inflammatory challenges impair outcome after stroke by increasing brain injury only or whether they have direct effects on brain oedema, cerebrovascular inflammation and blood-brain barrier damage...
  52. pmc Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia
    Bolanle M Famakin
    Stroke Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Rm 5B06, MSC 1401, Bethesda, MD 20892 1401, USA
    Brain Res 1388:148-56. 2011
    ..9±8.4mm(3). These findings show that disruption of MyD88 or TRIF signaling does not confer protection in brain ischemia and suggests the possibility of additional or alternate downstream adaptors during TLR signaling in cerebral ..
  53. doi Neuroprotective effects of ischemic postconditioning on global brain ischemia in rats through upregulation of hippocampal glutamine synthetase
    Weiqiao Zhang
    Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Road, Pudong New District, Shanghai 200127, China
    J Clin Neurosci 18:685-9. 2011
    ..05) GS expression compared with both the sham and ischemia-reperfusion groups, suggesting that upregulation of GS expression after ischemia constitutes a neuroprotective mechanism...
  54. ncbi Role of T lymphocytes and interferon-gamma in ischemic stroke
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Circulation 113:2105-12. 2006
  55. ncbi Inflammatory cytokines in acute ischemic stroke
    Antonino Tuttolomondo
    Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Italy
    Curr Pharm Des 14:3574-89. 2008
  56. doi Mobilization, endothelial differentiation and functional capacity of endothelial progenitor cells after ischemic stroke
    Míriam Navarro-Sobrino
    Neurovascular Research Laboratory, Neurovascular Unit and Neurology Department, Departament de Medicina, Universitat Autonoma de Barcelona, Vall d Hebron Hospital, Barcelona, Spain
    Microvasc Res 80:317-23. 2010
    ..Nonetheless, development of cell-based therapy for stroke will require further studies to identify those EPCs with the greatest therapeutic potential...
  57. doi Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats
    Y Jiang
    Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, PR China
    Neuroscience 172:398-405. 2011
    ..64, P<0.05). Our data suggest intranasal BDNF might protect the brain against ischemic insult by modulating local inflammation via regulation of the levels of cellular, cytokine and transcription factor in the experimental stroke...
  58. ncbi Protective role of reactive astrocytes in brain ischemia
    Lizhen Li
    Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology at Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 28:468-81. 2008
    Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due to the absence of suitable experimental models...
  59. doi The neurovascular unit, matrix proteases, and innate inflammation
    Gregory J del Zoppo
    Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 1207:46-9. 2010
    ..Recent experimental work suggests specific cell sources for MMP-9 generation and for matrix proteases from four distinct families that could impact neurovascular unit integrity...
  60. doi Cerebral ischemia: models, methods and outcomes
    Konstantin Alexander Hossmann
    Max Planck Institute for Neurological Research, Cologne, Germany
    Neuropharmacology 55:257-70. 2008
    Experimental research into brain ischemia contributes substantially to the understanding of ischemic injury mechanisms but suffers from its limited relevance for clinical treatment strategies...
  61. ncbi High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo
    G Faraco
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    J Neurochem 103:590-603. 2007
    ..Together, data underscore the neuropathological role of nuclear HMGB1, and point to the protein as a mediator of post-ischemic brain damage...
  62. pmc A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
    Daniel F Gudbjartsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:876-8. 2009
    ..21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples...
  63. ncbi Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons
    Toru Yamashita
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Neurochem 94:459-68. 2005
    ..These results suggest that endogenous IL-6 plays a critical role in preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia and that its role may be mediated by Stat3 activation...
  64. doi Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia
    Hong Shuo Sun
    Toronto Western Hospital Research Institute, Toronto, Ontario, Canada
    Nat Neurosci 12:1300-7. 2009
    ..However, TRPM7 suppression made neurons resistant to ischemic death after brain ischemia and preserved neuronal morphology and function...
  65. pmc Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway
    D Della-Morte
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Neuroscience 159:993-1002. 2009
    ..In conclusion, in vivo resveratrol pretreatment confers neuroprotection similar to IPC via the SIRT1-UCP2 pathway...
  66. ncbi Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis
    Wolf Rüdiger Schäbitz
    Department of Neurology, University of Munster, Germany
    Stroke 38:2165-72. 2007
    ..Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis...
  67. doi Matrix metalloproteinase-9 as a marker for acute ischemic stroke: a systematic review
    Maria Ramos-Fernandez
    Department of Emergency Medicine, University of Puerto Rico, Carolina, Puerto Rico
    J Stroke Cerebrovasc Dis 20:47-54. 2011
    ..MMP-9 is a possible marker for ongoing brain ischemia, as well as a predictor of hemorrhage in patients treated with t-PA.
  68. pmc Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival
    Kuniyasu Niizuma
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5487, USA
    J Neurochem 109:133-8. 2009
  69. ncbi Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender
    Xiaoling Li
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Exp Neurol 187:94-104. 2004
    ..This suggests that a short battery of tests including the neurological score, cylinder, and corner test may be adequate to rapidly and repeatedly assess sensorimotor dysfunction in mice of both genders...
  70. ncbi Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions
    Michelle Aarts
    Toronto Western Hospital Research Institute, 11 416 MC PAV, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Science 298:846-50. 2002
    ..This approach circumvents the negative consequences associated with blocking NMDARs and may constitute a practical stroke therapy...
  71. ncbi Inflammation in ischemic brain injury: timing is important
    Jasna Kriz
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Boulevard Laurier, Quebec, QC, G1V4G2, Canada
    Crit Rev Neurobiol 18:145-57. 2006
    ..There is increasing evidence that post-ischemic inflammation plays an important role in brain ischemia. However, whether inflammatory processes are deleterious or beneficial to recovery is presently a matter of ..
  72. pmc Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
    H J Marti
    Department of Molecular Cell Biology, the Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Am J Pathol 156:965-76. 2000
    ..Exogenous support of this natural protective mechanism might lead to enhanced survival after stroke...
  73. ncbi Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94
    M Asahi
    Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Charlestown 02129, USA
    J Cereb Blood Flow Metab 20:1681-9. 2000
    ..These data demonstrate that MMP-9 plays a deleterious role in the development of brain injury after focal ischemia...
  74. ncbi Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
    C Iadecola
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 17:9157-64. 1997
    ..iNOS inhibition may provide a novel therapeutic strategy targeted specifically at the secondary progression of ischemic brain injury...
  75. ncbi Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
    Ya Dan Wen
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 4:762-9. 2008
    ..These results demonstrate that ischemic insult activates autophagy and an autophagic mechanism may contribute to ischemic neuronal injury. Thus, autophagy may be a potential target for developing a novel therapy for stroke...
  76. pmc Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia
    E Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Neuroscience 158:983-94. 2009
    ..Inhibitors of metalloproteinases are available, but balancing the beneficial and detrimental effects of these agents remains a challenge...
  77. doi Recombinant human angiopoietin-1 ameliorates the expressions of ZO-1, occludin, VE-cadherin, and PKCα signaling after focal cerebral ischemia/reperfusion in rats
    Hang Yu
    Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, 110001, China Department of Physiology, Daqing Branch of Haerbin Medical University, Daqing 163319, China
    J Mol Neurosci 46:236-47. 2012
    ..This study demonstrated that Ang-1 may decrease the permeability of BBB in MCAO/R rat by upregulation of ZO-1, occludin, and VE-cadherin. The decreased expressions of PKCα and p-MLC induced by Ang-1 also involved in this process...
  78. ncbi Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia
    Zheng Gang Zhang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    J Cereb Blood Flow Metab 22:379-92. 2002
  79. ncbi Early release of HMGB-1 from neurons after the onset of brain ischemia
    Jianhua Qiu
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 28:927-38. 2008
    ..high-mobility group box 1 (HMGB-1) promotes inflammation in sepsis, but little is known about its role in brain ischemia-induced inflammation...
  80. ncbi S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
    Zezong Gu
    Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 297:1186-90. 2002
    ..These findings suggest a potential extracellular proteolysis pathway to neuronal cell death in which S-nitrosylation activates MMPs, and further oxidation results in a stable posttranslational modification with pathological activity...
  81. ncbi Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size
    A M Romanic
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Stroke 29:1020-30. 1998
    ..The present study was designed to investigate the effects of MMP expression after stroke...
  82. ncbi Neuroprotective effect of exogenous microglia in global brain ischemia
    Fumihiro Imai
    Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan
    J Cereb Blood Flow Metab 27:488-500. 2007
    ..It is possible that administration of exogenous microglia can be developed as a potential candidate therapy for central nervous system repair after transitory global ischemia...
  83. pmc Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia
    David W Howells
    National Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Melbourne, Victoria, Australia
    J Cereb Blood Flow Metab 30:1412-31. 2010
    ..The aim is to provide, for novice and expert alike, an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research...
  84. ncbi Timing for fever-related brain damage in acute ischemic stroke
    J Castillo
    Department of Neurology, Complexo Hospitalario Universitario de Santiago Hospital Xeral de Galicia, Barcelona, Spain
    Stroke 29:2455-60. 1998
    ..The aim of this study was to determine the prognostic value of body temperature measured at different times after onset of stroke...
  85. doi Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds
    Krishna A Dani
    Department of Neurology, Institute of Neurological Sciences, University of Glasgow Southern General Hospital, Glasgow, Scotland
    Ann Neurol 70:384-401. 2011
    ..The optimum perfusion values to identify tissue at risk of infarction in acute stroke are unclear. We systematically reviewed CT and MR perfusion imaging in acute ischemic stroke...
  86. doi The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke. The Johann Jacob Wepfer award 2011
    Wolf Dieter Heiss
    Max Planck Institute for Neurological Research, Cologne, Germany
    Cerebrovasc Dis 32:307-20. 2011
    ..As long as a validation of the mismatch selection paradigm is lacking, its use as a surrogate marker of outcome is limited...
  87. doi Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Cereb Blood Flow Metab 29:464-79. 2009
    ..Taken together, the information suggests that IL-6 plays a double role in cerebral ischemia, as an inflammatory mediator during the acute phase and as a neurotrophic mediator between the subacute and prolonged phases...
  88. ncbi Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats
    Jieli Chen
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Mich, USA
    Circ Res 92:692-9. 2003
    ..These data suggest that treatment of stroke with hMSCs enhances angiogenesis in the host brain and hMSC-enhanced angiogenesis is mediated by increases in levels of endogenous rat VEGF and VEGFR2...
  89. ncbi Rapid tolerance to focal cerebral ischemia in rats is induced by preconditioning with electroacupuncture: window of protection and the role of adenosine
    Qiang Wang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 Shaanxi, China
    Neurosci Lett 381:158-62. 2005
    ..The rapid ischemic tolerance appears at 2 h (but not at 0.5, 1, or 3 h) after preconditioning, and is possibly mediated through an adenosine A1 receptor-related mechanism...
  90. pmc Microglial involvement in neuroplastic changes following focal brain ischemia in rats
    Alexandre Madinier
    Unité INSERM U887 Motricité Plasticité, Dijon, France
    PLoS ONE 4:e8101. 2009
  91. ncbi Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke
    Randall T Higashida
    University of California, San Francisco Medical Center, Department of Radiology, 505 Parnassus Ave, Rm L 352, San Francisco, CA 94143 0628, USA
    Stroke 34:e109-37. 2003
  92. ncbi Dual role of tumor necrosis factor alpha in brain injury
    E Shohami
    Department of Pharmacology, Hebrew University School of Pharmacy, Jerusalem, Israel
    Cytokine Growth Factor Rev 10:119-30. 1999
    ..It is suggested that the appropriate context of mediators, at any given time after brain injury may well determine whether the effect of TNF alpha is protective or toxic...
  93. doi Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
    K Hyakkoku
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    Neuroscience 171:258-67. 2010
    ..These data suggest that TLR4 knockout, but not TLR3 or TLR9 knockout, may play a neuroprotective role in ischemic brain injury induced by MCAO in mice...
  94. ncbi Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia
    Hideo Shichinohe
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Brain Res 1029:200-6. 2004
    ..These findings suggest that Edaravone salvages the boundary zone of infarct by scavenging reactive oxygen species especially in the neurons during permanent focal cerebral ischemia...
  95. doi Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation
    A Denes
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Brain Behav Immun 24:708-23. 2010
    ..However, a greater understanding of the contribution of inflammation to CI is still required, and this review highlights some of the key mechanism that may offer future therapeutic targets...
  96. ncbi Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, California 94305, USA
    J Neurosci 25:9794-806. 2005
    ..Hypothermia may protect from ischemic damage in part by preserving Akt activity and attenuating the apoptotic effects of PTEN, PDK1, and FKHR...
  97. pmc Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury
    Susan L Stevens
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 31:8456-63. 2011
    ..of the TLR4 ligand LPS or the TLR9 ligand unmethylated CpG oligodeoxynucleotide before transient brain ischemia in mice confers substantial protection against ischemic damage...
  98. ncbi A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia
    Joanna Dluzniewska
    Molecular Biology Unit, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    FASEB J 19:1896-8. 2005
    ..In vivo, in a gerbil model of transient brain ischemia, treatment with the synthetic MGF C-terminal peptide provided very significant protection to the vulnerable ..
  99. doi JNK inhibition and inflammation after cerebral ischemia
    Corinne Benakis
    Department of Neurology, University Hospital CHUV, Lausanne, Switzerland
    Brain Behav Immun 24:800-11. 2010
    ..In contrast, in vitro data show an indirect effect of D-JNKI1 on the modulation of microglial activation...
  100. ncbi Intracerebroventricular injection of microglia protects against focal brain ischemia
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 94:203-6. 2004
    ..At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion...
  101. pmc Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage
    Jens P Dreier
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Brain 132:1866-81. 2009

Research Grants113 found, 100 shown here

  1. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  2. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
  3. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
  4. Cerebral metabolism, EEG, and sleep cycling in critically ill neonates
    Renée A Shellhaas; Fiscal Year: 2013
    ..abstract_text> ..
  5. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..This proposal explores the therapeutic potential of D609 and how it affects lipid second messenger ceramide that regulates the cell cycle both in vitro and in vivo stroke models. ..
  6. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..In addition, we expect that this method of cooling will produce less physiologic stress compared with traditional cooling protocols. ..
  7. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling;and 2) the size of these changes are correlated over time, ROI, and treatment. ..
  8. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
  9. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
  10. Therapeutic Strategies for Neonatal Hypoxic-Ischemic Encephalopathy
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2012
    Gregory J Zipfel; Fiscal Year: 2013
    ..If successful, the results of the project may point to ways to develop effective treatments to prevent or reverse the memory problems of patients with Alzheimer's Disease in the future. ..
  12. White Matter Protection in Cerebral Ischemia
    Guodong Cao; Fiscal Year: 2013
    ..The effect of NAMPT on microglial myelin phagocytosis, oligodendrogenesis, WMI, and functional outcomes after ischemia will be evaluated. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
  13. HMG in Post Operative and Traumatic Stress
    Kevin J Tracey; Fiscal Year: 2013
  14. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..We will then examine whether this effect is important in reducing the amount of tissue damage and neurologic impairment caused by the stroke. ..
  15. Investigation of underlying mechanisms of sex differences in cerebral ischemia
    Chad S Siegel; Fiscal Year: 2010
    ..The overall goal of this proposal is to investigate mechanisms underlying sex differences in ischemic cell death. ..
  16. Age-dependent microglial responses in hypoxia-ischemia
    PETER A FERRAZZANO; Fiscal Year: 2013
  17. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Brain ischemia results in permanent disability and death for thousands of patients annually...
  18. Stress Proteins in Brain Cell Injury
    Rona G Giffard; Fiscal Year: 2013
    ..Overall this proposal exams a novel hypothesis: that miRNAs act as master regulators of chaperones and BCL2 family members influencing Ca2+ homeostasis, mitochondria-ER crosstalk, and outcome after cerebral ischemia. ..
  19. Optical spectroscopy to study mitochondrial function within replicating cells
    Roger J Springett; Fiscal Year: 2010
    ..The goal of this application is to develop this technology to fruition so that it can be used study the regulation of mitochondria in normal cells and how this regulation fails in human disease. ..
  20. Kinase/Phosphatase-mediated Mitochondrial Restructuring in Neuroprotection
    Stefan Strack; Fiscal Year: 2012
  21. Endothelial Aromatase in Sex-Specific Cerebrovascular Dysfunction After Ischemia
    KRISTEN LEANNE ZULOAGA; Fiscal Year: 2012
    Costantino Iadecola; Fiscal Year: 2013
    ..dysfunction;(4) The detrimental cerebrovascular effects of CIH deplete cerebrovascular reserves, aggravate the brain ischemia induced by middle cerebral artery occlusion, and increase the resulting tissue damage...
  23. Heat shock proteins in brain ischemia and stroke
    Midori A Yenari; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stroke is a common affliction among veterans, and treatments are few. Brain ischemia frequently causes disruption of the blood brain barrier (BBB) leading to brain edema and hemorrhage which can ..
  24. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D RICHARD MILNER; Fiscal Year: 2012
    ..If successful, this work could have major impact on the incidence and mortality of ischemic stroke. ..
  25. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..If successful, the findings of these exploratory studies will be used in near future translational studies designed to optimize tVNS treatment for acute ischemic stroke in humans. ..
  26. Endogenous regulators of inflammation in liver ischemia/reperfusion
    Allan Tsung; Fiscal Year: 2013
    ..g. myocardial infarction and cerebral ischemia). ..
  27. CaMKII in global cerebral ischemia
    Paco S Herson; Fiscal Year: 2013
  28. Role of Astrocytic TREK-2 Potassium Channels in Cerebral Ischemia
    Misty J Eaton; Fiscal Year: 2013
  29. SK2 Channels as Novel Neuroprotective Targets Against Cerebral Ischemia
    Paco S Herson; Fiscal Year: 2012
  30. Elevated Zinc in Ischemia and reperfusion
    Yang V Li; Fiscal Year: 2013
  31. Elucidating the role of the eIF2alpha kinase PERK in synaptic plasticity and memo
    MY AI TRINH; Fiscal Year: 2010
    ..PERK primarily has been studied in pancreatic cellular stress response and global brain ischemia;however, its role in protein synthesis-dependent hippocampal synaptic plasticity is poorly understood...
  32. Mechanisms and Modulation of Cell Death in Traumatic Brain Injury
    ALAN IRA FADEN; Fiscal Year: 2012
    ..from the mitochondria to the nucleus, in association with apoptotic morphological features, occurs after acute brain ischemia or TBI...
  33. Development of Potent/Selective Lipoxygenase Therapeutics Against Stroke Injury
    Theodore R Holman; Fiscal Year: 2013
    ..Considering that our "validated hit" manifests a 30% reduction in infarct size, we are confident these studies will discover a 12/15- LOX inhibitor as an effective therapeutic against stroke damage. ..
  34. Matrix and trophic coupling in the neurovascular unit
    Eng H Lo; Fiscal Year: 2011
    ..Taken together, these data should support our basic hypothesis that cerebral endothelial cells are not just inert conduits for blood flow, but also play a key role in matrix and trophic coupling for the neuron. ..
  35. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2013
    ..The hypothesis to be tested is that GPR30 agonist G1, like E2, alters Treg induction, mitigating immunosuppression while concurrently protecting the recovering brain. ..
  36. Sex differences in brain inflammation in experimental stroke
    Halina Offner; Fiscal Year: 2013
    ..Findings from this application could therefore lead to the development of new therapies for stroke such as PPAR[unreadable] agonists for females and MMP-9 antagonists for males. ..
  37. Mitochondria, Superoxide &MnSOD in a fetal hypoxic cerebral palsy model
    Matthew Derrick; Fiscal Year: 2012
    ..This proposal aims to understand how lack of oxygen causes brain damage and will test potential treatments that could decrease the severity of brain damage and prevent the child from developing cerebral palsy. ..
  38. Kinase/Phosphatase-mediated Mitochondrial Restructuring in Neuroprotection
    Stefan Strack; Fiscal Year: 2013
    ..The proposed studies will increase our mechanistic understanding of mitochondrial fragmentation and its regulation by reversible phosphorylation in neurons, which may lead to better therapies for neurodegeneration in stroke and disease. ..
  39. Hydrogen Sulfide in Newborn Cerebral Circulation
    Charles W Leffler; Fiscal Year: 2013
    ..The gasotransmitter, H2S, will certainly prove to be one of these major mechanisms of which greater understanding is urgently needed. ..
  40. Cytokines and the blood-brain barrier in the ovine fetus
    Barbara S Stonestreet; Fiscal Year: 2012
    ..b>Brain ischemia is induced by carotid occlusion...
  41. THAPCA Trials - Scientific Application
    Frank W Moler; Fiscal Year: 2012
    ..The THAPCA Trials are studies that will determine whether whole body cooling of children who have had cardiac arrest will result in better survival and less brain injury. ..
  42. THAPCA Trials - DCC Application
    JONATHAN MICHAEL DEAN; Fiscal Year: 2013
    ..The THAPCA Trials are studies that will determine whether whole body cooling of children who have had cardiac arrest will result in better survival and less brain injury. ..
  43. Erythropoietin and Neurogenesis after Neonatal Stroke
    ..These can then be tailored to the newborn brain, which will reduce the frequency and severity of poor outcomes in the newborn. ..
  44. Role of Metallothioneins in Isoflurane-Preconditioning of neurons in vitro.
    Adam C Hall; Fiscal Year: 2010
    ..This work has important implications for prophylactic treatment against stroke in clinical settings and for operative/perioperative treatment against ischemia. ..
    Li Huei Tsai; Fiscal Year: 2013
  46. Broadly Neuroprotective Drug for TBI
    Fernando Gomez Pinilla; Fiscal Year: 2010
    ..We expect to generate valuable pre-clinical information that will entitle us to initiate the steps for seeking IND approval. ..
  47. Novel Signaling Pathways in Ischemic Stroke
    JAMES KUANG JAN LIAO; Fiscal Year: 2013
    ..This research application proposes to investigate the role of an emerging signaling pathway, Rho kinase (ROCK), in platelets as a potential therapeutic target for preventing and treating ischemic strokes. ..
  48. Maternal Diet and Susceptibility to Neonatal Brain Injury
    John D Barks; Fiscal Year: 2013
    ..S. population. ..
  49. Neuron-Dervied S1P and Endothelial Function in Stroke
    Christian Waeber; Fiscal Year: 2010
    ..This project will study a novel system that can provide long-lasting improvement in EC function following stroke and serve as a target for stroke therapy. ..
  50. MicroRNA-Mediated Translation Initiation Arrest In Ischemic Brain
    Julie Anne Saugstad; Fiscal Year: 2013
    ..Our findings could also lead to development of novel stroke therapies based on miRNAs and their potential for regulating translation initiation in ischemic brain. ..
  51. Mechanisms of Receptor Regulated Na+-H+ Exchange
    Diane L Barber; Fiscal Year: 2013
    ..We also will ask whether over expression of Dnhe2 cooperates with oncogene activation or tumor suppressor deletion to induce metastatic cancer, and will use modifier screens to identify mediators of the Dnhe2 over expression phenotype. ..
  52. Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in Emphysema
    Irina Petrache; Fiscal Year: 2013
    Ying Xia; Fiscal Year: 2013
    ..Our preliminary studies have shown that this proposal is feasible and will very likely yield important information on the EA-induced protection and eventually shed light on new therapeutic modalities of stroke. ..
  54. Nitroalkene-Mediated Vascular Protection and Ischemic Stroke
    Yuqing Eugene Chen; Fiscal Year: 2013
  55. Heat Shock Protein Therapeutics for Stroke
    Frank R Sharp; Fiscal Year: 2013
    ..We also propose that monitoring gene expression changes in peripheral blood that correlate with effective stroke treatments in rodents can be used to assess potential treatment responsiveness in humans. ..
  56. Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for Stroke
    Irina Y Sazonova; Fiscal Year: 2012
    ..In this project we propose a novel thrombolytic agent and plan to determine its efficacy for the treatment in an experimental model of thromboembolic cerebral ischemia. ..
  57. EPR and Mossbauer Characterization of Mn and Fe Proteins, Models, Intermediates
    Michael P Hendrich; Fiscal Year: 2013
    ..We have created software for the interpretation of EPR spectra which allows an unprecedented ability to quantitatively characterize virtually all paramagnetic metal sites in proteins and enzymes. ..
  58. TWEAK-Induced Neuroinflammation and Cerebral Edema
    MANUEL SALVADOR YEPES; Fiscal Year: 2013
    ..Importantly, if our hypothesis is correct, our findings should indicate whether inhibition of TWEAK-Fn4 binding is a valid new target for the treatment of patients with acute ischemic stroke. ..
  59. Cell Death/Survival After Global Cerebral Ischemia
    Pak H Chan; Fiscal Year: 2013
    Project Summary/Abstract It is well established that a brief period of global brain ischemia causes delayed cell death in vulnerable hippocampal CA1 pyramidal neurons days after reperfusion in animals and humans...
  60. Histone deacetylases - therapeutic targets for functional restoration after strok
    SEAN PADRAIG MURPHY; Fiscal Year: 2013
    ..Selected drugs will be tested to reveal what functional benefits they confer on the recovery of mice from stroke injury. ..
  61. Mechanisms of G-CSF-Induced Neuroprotection
    Jiping Tang; Fiscal Year: 2012
    ..Achieving our goal will lay the foundation for clinical evaluation of systemic administration of G-CSF in human neonates for prevention and treatment of brain damage from hypoxia/ischemia. ..
  62. 12/15-Lipoxygenase and neurovascular damage following cardiac arrest
    Klaus van Leyen; Fiscal Year: 2013
    ..Elucidating the role of 12/15-LOX in mediating ischemic damage may lead to novel therapeutic options in treating cardiac arrest patients. ..
    Jun Chen; Fiscal Year: 2012
    ..This information will be valuable for future development of new therapeutic strategies for the treatment of stroke. ..
  64. Targeting the Pial Collateral Circulation for Mitigation of Cerebral Ischemia
    James E Faber; Fiscal Year: 2013
    ..Identifying this major allele that when polymorphic impairs collateral formation may also provide a genetic marker for use in these same patient groups. ..
  65. Nitrite based neuroprotection after cardiac arrest
    Cameron Dezfulian; Fiscal Year: 2013
    ..NIH-funded neuroscientist who studies mechanisms of neuroprotection and mitochondrial dysfunction after brain ischemia. Dr. Dezfulian will be co-mentored by Dr...
  66. PAR-1 Signaling and HAND
    ..Moreover, newly developed orally available PAR-1 antagonists that are now in clinical trials for coronary artery disease might be considered for treatment of the same. ..
  67. Mechanisms of early brain injury after subarachnoid hemmorrhage
    Guohua Xi; Fiscal Year: 2013
    ..The purpose of our project is to examine mechanisms of early brain injury after SAH. Data from the proposed studies may lead to new therapies for SAH. The long-term goal of our studies is to limit brain damage in SAH patients. ..
  68. Noninvasive, Optoacoustic Monitoring of Cerebral Circulation in Preterm Neonates
    GRAHAM RANDALL; Fiscal Year: 2013
    ..Specific Aim 3. Preliminarily establish in vivo in neonates the range of SSSSO2 to be expected in infants of varying body weight (10-12 LBW neonates and 10-12 VLBW neonates). ..
  69. US-China Collaborative Research on Stroke Imaging
    Jinyuan Zhou; Fiscal Year: 2013
    ..are: (i) to assess the characteristics and spatio-temporal evolution of perfusion/pH/diffusion deficits in rat brain ischemia/reperfusion models;and (ii) to determine the radiologic characteristics and clinical values of pH imaging of ..
  70. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..Our findings will be relevant to the development of novel therapeutic strategies targeting pro- inflammatory pathways in AD. ..
  71. Restoration of Endoplasmic Reticulum Function in Experimental Stroke
    Wulf Paschen; Fiscal Year: 2013
  72. Mu Center for Botanical Interaction Studies
    Dennis B Lubahn; Fiscal Year: 2013
  73. PGE2 EP1 and EP3 receptors as therapeutic targets in intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2013
    ..This proof-of-concept information is required to plan more detailed preclinical assessment of selective EP1 and EP3 receptor antagonists in ICH. ..
  74. FASEB SRC on The Biology of Calpains in Health and Disease
    James W Geddes; Fiscal Year: 2013
    ..The proposed program will provide the forum by which the momentum in this field may be maintained. ..
  75. Role of Nrf2 in Ischemic Preconditioning-Induced Neuroprotection
    Srinivasan V Narayanan; Fiscal Year: 2013
    ..These proposed studies will enhance our understanding of IPC, and how Nrf2 can be exploited to develop novel prophylactic therapy for the treatment of cerebral ischemia. ..
  76. The Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain Injury
    Wenhan Chang; Fiscal Year: 2013
    ..The successful completion of the study will establish a novel pathway that produces ischemia-induced neuronal injury and will develop a new therapy for treating diseases due to ischemic brain injury. ..
    MARTHA E O'DONNELL; Fiscal Year: 2013
    ..We will also assess the efficacy of NKCC, NHE and NBC inhibitors for reduction of edema when administered after the onset of ischemia. ..
  78. Role of SUMO Conjugation in Ischemia: Significance, Mechanisms and Pathways
    Wulf Paschen; Fiscal Year: 2013
  79. Sulfonylurea receptor 1 (SUR1) - A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2013
    ..called the SUR1/TRPM4 channel) plays a critical role in edema, lesion expansion and cell death following brain ischemia. New preliminary data for this proposal, obtained with a severe ischemia/reperfusion models (6-h MCAo/48 h ..
  80. Microglial Signal Transduction in Fever and Vasospasm after Subarachnoid Hemorrha
    Khalid A Hanafy; Fiscal Year: 2013
    ..We are confident that Dr. Hanafy has the tools to complete his project as outlined and hope he will become a successful NIH funded investigator. ..
  81. Mitochondrial Integrity Regulates Cerebral Reperfusion Injury
    THOMAS HUDSON SANDERSON; Fiscal Year: 2013
    ..We hypothesize that, following brain ischemia, mitochondrial dynamics defaults to increased mitochondrial fission as a result of impaired fusion, thus ..
  82. Early Biomarkers in Neonatal Brain Injury
    Sonia L Bonifacio; Fiscal Year: 2013
  83. POINT: Platelet-Oriented Inhibition in New TIA
    Yuko Y Palesch; Fiscal Year: 2013
    ..If the trial is positive, treatment with clopidogrel could reduce the stroke burden in the US and substantially reduce costs of care. ..
  84. Integrative Genomics of Stroke
    Rose Du; Fiscal Year: 2013
    ..This project uses a mouse model of stroke to examine the genetic basis of stroke susceptibility. This will be accomplished via computational and bioinformatics tools together with the emerging genetics resources. ..
  85. Atrial Fibrillation Precursors May Be Novel Stroke Risk Factors
    Hooman Kamel; Fiscal Year: 2013
    ..abstract_text> ..
  86. The Role of CaMK Cascade in Stroke
    Jun Li; Fiscal Year: 2013
    ..These studies represent the first steps in improving our understanding of the endogenous signaling pathways that are activated by calcium in the ischemic brain. ..
  87. The Immunoinhibitory Role of CD200-CD200R1 Signaling in Experimental Stroke
    Rodney Ritzel; Fiscal Year: 2013
  88. Epigenomics of Patient Outcomes after Aneurysmal SAH
    Yvette Conley; Fiscal Year: 2013
  89. Pre-clinical Development of a Context-Dependent NMADR Neuroprotectant for Treatme
    SCOTT JAMES MYERS; Fiscal Year: 2013
  90. ABetaPP Influences Cerebral Thrombosis
    William E Van Nostrand; Fiscal Year: 2013
  91. Mild Cognitive Impairment and Obstructive Sleep Apnea
    Kathy Culpepper Richards; Fiscal Year: 2013
    ..Additional potential study benefits are increased understanding of the physiological mechanisms for cognitive decline in oaMCI and OSA, and the characteristics of those most likely to benefit from this treatment. ..
  92. Microscale Oxygenation Mapping During Stroke
    Andrew K Dunn; Fiscal Year: 2013
    ..Finally, we will quantify the relationship between oxygen levels surrounding individual dendrites and morphological changes in these dendrites during both acute and chronic ischemia. ..
  93. Modeling of Collateral Perfusion in the Ischemic Brain
    ..and provision of mentoring opportunities, a tangible resulting product will be a software tool to enhance prediction of tissue fate and neurological outcomes in acute stroke across diverse causes of brain ischemia.
  94. CYP 450-mediated CBF Dysregulation and Neurotoxicity in Pediatric Cardiac Arrest
    Mioara D Manole; Fiscal Year: 2013
    Mark J Fisher; Fiscal Year: 2013
    ..Part of the novelty of the project is the genuine collaborative multi-PI effort that combines expertise in stroke and Alzheimer's disease, contributing to the high translational significance. ..
  96. Brain regions involved in seasonally dependent A1AR agonist-induced torpor
    Kelly L Drew; Fiscal Year: 2013
    ..Preliminary data suggest that mechanisms used by hibernating mammals to decrease body temperature will translate to non-hibernating species. ..
  97. Constrictor / Mitogen Induced Remodeling of Cerebral Arterioles
    JAY HUMPHREY; Fiscal Year: 2009
    ..This study will be the first to propose and test this new hypothesis as well as a potential means to block this remodeling. ..
  98. Vascular Mechanisms of Secondary Injury After Traumatic Brain Injury
    Claudia S Robertson; Fiscal Year: 2012
    ..Effect of Erythropoietin on Anemia and Need for Transfusion Project 3. EDHF Following Traumatic Brain Injury Project 4. Neuroprotection of Erythropoietin Signaling in TBI ..
  99. VEGF in Ischemic Neuroprotection, Neurodegeneration and Repair
    DAVID ALAN GREENBERG; Fiscal Year: 2013 months after stroke, suggesting that endogenous mechanisms exist for limiting and reversing the effects of brain ischemia. These include neuroprotection, which prevents the progression of reversible to irreversible injury, and ..
  100. IL-1 in Protection and Injury
    Sandra J Hewett; Fiscal Year: 2013 increase GSH levels to reduce oxidative injury), and when appropriate, to employ strategies to reduce its activity to decrease the probability of excitotoxic neuronal injury (i.e. under conditios where glutamate uptake is impaired). ..
  101. In vivo Inhibition of Specific microRNAs to Support Post-Stroke Revascularization
    Tamara Roitbak; Fiscal Year: 2013
    ..We believe that the proposed research is significant because it is expected to lead to the development of novel therapeutic strategies for improving the post-ischemic recovery. ..