brain ischemia

Summary

Summary: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Top Publications

  1. ncbi Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros
    Harold P Adams
    Stroke 38:1655-711. 2007
  2. ncbi Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
  3. ncbi Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
  4. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
  5. ncbi Subarachnoid haemorrhage
    Jan van Gijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
    Lancet 369:306-18. 2007
  6. ncbi Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    A Furlan
    Cerebrovascular Center, Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
    JAMA 282:2003-11. 1999
  7. ncbi Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Leukoc Biol 87:779-89. 2010
  8. ncbi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
  9. ncbi Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    Mélanie Lalancette Hébert
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada G1V 4G2
    J Neurosci 27:2596-605. 2007
  10. ncbi Role of inflammatory markers in brain ischemia
    Manuel Rodríguez-Yáñez
    Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Curr Opin Neurol 21:353-7. 2008

Research Grants

  1. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 2002
  2. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN FADEN; Fiscal Year: 2009
  3. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
  4. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1993
  5. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D RICHARD MILNER; Fiscal Year: 2010
  6. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D Milner; Fiscal Year: 2009
  7. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2007
  8. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2005
  9. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2010
  10. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2009

Detail Information

Publications263 found, 100 shown here

  1. ncbi Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atheros
    Harold P Adams
    Stroke 38:1655-711. 2007
    ..Because many of the recommendations are based on limited data, additional research on treatment of acute ischemic stroke is needed...
  2. ncbi Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
    ..We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke...
  3. ncbi Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
    ..Disrupted TJPs previously seen in endothelial cells appeared in the surrounding astrocytes. Our results provide direct evidence that MMPs open the BBB by degrading TJPs and that an MMP inhibitor prevents degradation of the TJPs by MMPs...
  4. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  5. ncbi Subarachnoid haemorrhage
    Jan van Gijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
    Lancet 369:306-18. 2007
    ..Hydrocephalus might cause gradual obtundation in the first few hours or days; it can be treated by lumbar puncture or ventricular drainage, dependent on the site of obstruction...
  6. ncbi Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    A Furlan
    Cerebrovascular Center, Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
    JAMA 282:2003-11. 1999
    ..Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed...
  7. ncbi Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Leukoc Biol 87:779-89. 2010
    ..We discuss how these cells contribute to ischemic brain injury and highlight certain recent findings and currently unanswered questions about inflammatory cells in the pathophysiology of ischemic stroke...
  8. ncbi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
    ..The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury...
  9. ncbi Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    Mélanie Lalancette Hébert
    Department of Anatomy and Physiology, Laval University, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada G1V 4G2
    J Neurosci 27:2596-605. 2007
    ....
  10. ncbi Role of inflammatory markers in brain ischemia
    Manuel Rodríguez-Yáñez
    Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Curr Opin Neurol 21:353-7. 2008
    Inflammatory mechanisms play an important role in the risk of stroke and during the acute phase of brain ischemia, which contributes to functional outcome of patients...
  11. ncbi Therapeutic hypothermia for brain ischemia: where have we come and where do we go?
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, CA 94121, USA
    Stroke 41:S72-4. 2010
    ..We review the state of therapeutic hypothermia in ischemic and hemorrhagic stroke and provide an outlook for its role in stroke therapy...
  12. ncbi Role of T lymphocytes and interferon-gamma in ischemic stroke
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Circulation 113:2105-12. 2006
    ....
  13. ncbi Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Japan
    Cell 110:429-41. 2002
    ..These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases...
  14. ncbi Protective effect of exogenous administration of alpha-tocopherol in middle cerebral artery occlusion model of cerebral ischemia in rats
    Geeta Chaudhary
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India
    Fundam Clin Pharmacol 17:703-7. 2003
    ..The results demonstrate that exogenous administration of alpha-tocopherol is able to reduce the neuronal damage caused during ischemia-reperfusion, which can be attributed to its antioxidant activity...
  15. ncbi Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94
    M Asahi
    Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Charlestown 02129, USA
    J Cereb Blood Flow Metab 20:1681-9. 2000
    ..These data demonstrate that MMP-9 plays a deleterious role in the development of brain injury after focal ischemia...
  16. ncbi Exciting, radical, suicidal: how brain cells die after stroke
    Eng H Lo
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, MGH East 149-2401, Charlestown, MA 02129, USA
    Stroke 36:189-92. 2005
  17. ncbi Update of the stroke therapy academic industry roundtable preclinical recommendations
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stroke 40:2244-50. 2009
    ..Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success...
  18. ncbi Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
    ..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
  19. ncbi Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation
    A Denes
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Brain Behav Immun 24:708-23. 2010
    ..However, a greater understanding of the contribution of inflammation to CI is still required, and this review highlights some of the key mechanism that may offer future therapeutic targets...
  20. ncbi Inflammatory cytokines in acute ischemic stroke
    Antonino Tuttolomondo
    Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Italy
    Curr Pharm Des 14:3574-89. 2008
    ....
  21. ncbi Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    D B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 98:1952-7. 2001
    ..Our discovery that ER alpha mediates protection of the brain carries far-reaching implications for the selective targeting of ERs in the treatment and prevention of neural dysfunction associated with normal aging or brain injury...
  22. ncbi Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury
    J Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Neurosci 21:5272-80. 2001
    ....
  23. ncbi Reactive oxygen radicals in signaling and damage in the ischemic brain
    P H Chan
    Department of Neurosurgery, Stanford University School of Medicine, California 94205-5487, USA
    J Cereb Blood Flow Metab 21:2-14. 2001
    ..Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury...
  24. ncbi Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery
    S B Frost
    Center on Aging, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurophysiol 89:3205-14. 2003
    ..Reorganization in intact tissue may provide a neural substrate for adaptive motor behavior and play a critical role in postinjury recovery of function...
  25. ncbi Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
    Kunlin Jin
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Mol Cell Neurosci 24:171-89. 2003
    ..These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery...
  26. ncbi Apoptotic and antiapoptotic mechanisms in stroke
    M P Mattson
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224 6825, USA
    Cell Tissue Res 301:173-87. 2000
    ..Interestingly, recent studies suggest novel dietary approaches (e.g., food restriction and supplementation with antioxidants) that may reduce brain damage following stroke...
  27. ncbi Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke
    W M Clark
    Oregon Stroke Center, Portland 97201, USA
    JAMA 282:2019-26. 1999
    ..This restricts the number of patients who can be treated, since most stroke patients present more than 3 hours after symptom onset...
  28. ncbi Neuroprotective properties of statins in cerebral ischemia and stroke
    C J Vaughan
    Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, NY 10021, USA
    Stroke 30:1969-73. 1999
    ..In this article, we review the emerging evidence that statins have beneficial effects within the cerebral circulation and brain parenchyma during ischemic stroke and reperfusion...
  29. ncbi Hospitalizations for incident stroke in Shunde District, Foshan, South China
    Wenbin Liang
    School of Public Health, Curtin University of Technology, Perth, WA, Australia
    Neuroepidemiology 30:101-4. 2008
    ..However, CT scan and MRI were not widely used in China until the middle 1990s. We estimate the stroke incidence based on stroke hospitalizations in Shunde District, Foshan, south China...
  30. ncbi Matrix metalloproteinases and free radicals in cerebral ischemia
    K Jian Liu
    College of Pharmacy, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Free Radic Biol Med 39:71-80. 2005
    ..Understanding the relationship between proteases and free radicals in cerebral ischemia is critical for the design of therapeutic agents aimed at controlling cell death in ischemic tissues...
  31. ncbi Efficacy of rehabilitative experience declines with time after focal ischemic brain injury
    Jeff Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's Campus, Newfoundland, Canada A1B 3V6
    J Neurosci 24:1245-54. 2004
    ..These findings have important implications for rehabilitation of stroke patients, many of whom experience considerable delays before therapy is initiated...
  32. ncbi Inflammation and infection in clinical stroke
    Hedley C A Emsley
    University of Manchester and Stroke Services, Clinical Sciences Building, Hope Hospital, Eccles Old Road, Salford, M6 8HD, U K
    J Cereb Blood Flow Metab 22:1399-419. 2002
    ..Newer approaches have included antimicrobial and antileukocyte strategies. One of the most promising avenues may be the use of cytokine antagonism, for example, interleukin-1 receptor antagonist...
  33. ncbi Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture
    Myron D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
    Stroke 34:214-23. 2003
    ..This presentation first highlights insights into the ischemic penumbra enabled by a multimodal experimental approach; second, discusses gene expression in ischemia; and third, confronts the challenges of neuroprotectant therapy...
  34. ncbi Evidence for stroke-induced neurogenesis in the human brain
    Kunlin Jin
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:13198-202. 2006
    ..These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy...
  35. ncbi Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine
    Ruediger Hilker
    Department of Neurology, University Hospital, Cologne, Germany
    Stroke 34:975-81. 2003
    ..Our results allow us to identify high-risk stroke patients at time of NICU admission in whom the use of preventive treatment strategies is most promising...
  36. ncbi Stroke-induced immunodepression: experimental evidence and clinical relevance
    Ulrich Dirnagl
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Stroke 38:770-3. 2007
    ..Nevertheless, clinical evidence is emerging demonstrating that stroke-induced immunodepression in humans not only exists, but has very similar features to those characterized in rodent experiments...
  37. ncbi Combination therapy with hypothermia for treatment of cerebral ischemia
    Xian N Tang
    Department of Neurology, University of California, San Francisco and San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
    J Neurotrauma 26:325-31. 2009
    ..The experimental data nevertheless seem to favor a combinatorial approach. Thus, in order to apply hypothermia to a broader range of patients, combination strategies should be further investigated...
  38. ncbi Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage
    Jens P Dreier
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Brain 132:1866-81. 2009
    ....
  39. ncbi The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:2849-58. 2009
    ..Herein, we characterize the impact of 3 ischemia models on systemic immunological and microbiological parameters...
  40. ncbi Transcranial Doppler for predicting delayed cerebral ischemia after subarachnoid hemorrhage
    Emmanuel Carrera
    Neurological Intensive Care Unit, Departments of Neurology and Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 65:316-23; discussion 323-4. 2009
    ..We sought to determine the prognostic utility of serial TCD examination after SAH...
  41. ncbi Recurrent spontaneous spreading depolarizations facilitate acute dendritic injury in the ischemic penumbra
    W Christopher Risher
    Graduate Program in Neuroscience, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 30:9859-68. 2010
    ..We propose that metabolic stress resulting from recurring SDs facilitates acute injury at the level of dendrites and dendritic spines in metabolically compromised tissue, expediting penumbral recruitment into the ischemic core...
  42. ncbi Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study
    Rolf T Urbanus
    Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet Neurol 8:998-1005. 2009
    ....
  43. ncbi Recombinant C1 inhibitor in brain ischemic injury
    Raffaella Gesuete
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Ann Neurol 66:332-42. 2009
    ..We have explored the efficacy and the therapeutic window of the recently available human recombinant (rh) C1-INH on ischemic brain injury and investigated its mechanism of action in comparison with that of plasma-derived (pd) C1-INH...
  44. ncbi The poor outcome of ischemic stroke in very old people: a cohort study of its determinants
    Licia Denti
    Geriatric and Rehabilitation Department, University Hospital of Parma, Parma, Italy
    J Am Geriatr Soc 58:12-7. 2010
    ..To assess how much of the excess risk of poor outcome from stroke in people aged 80 and older aging per se explains, independent of other prognostic determinants...
  45. ncbi Hemispheric hypoperfusion in postictal paresis mimics early brain ischemia
    Sven Rupprecht
    Department of Neurology, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Epilepsy Res 89:355-9. 2010
    ..Further investigations are warranted to clarify the role of cerebrovascular dysfunction in the pathophysiology of postictal paresis...
  46. ncbi Experimental and preliminary clinical evidence of an ischemic zone with prolonged negative DC shifts surrounded by a normally perfused tissue belt with persistent electrocorticographic depression
    Ana I Oliveira-Ferreira
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 30:1504-19. 2010
    ..These preliminary results suggest that the ischemic zone in rat and human cortex is surrounded by a normally perfused belt with persistently reduced synaptic activity during the acute injury phase...
  47. ncbi Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival
    Kuniyasu Niizuma
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5487, USA
    J Neurochem 109:133-8. 2009
    ....
  48. ncbi The "golden hour" and acute brain ischemia: presenting features and lytic therapy in >30,000 patients arriving within 60 minutes of stroke onset
    Jeffrey L Saver
    Department of Neurology, University of California, Los Angeles, Calif 90095, USA
    Stroke 41:1431-9. 2010
    The benefit of intravenous thrombolytic therapy in acute brain ischemia is strongly time dependent.
  49. ncbi Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic
    Manuel Yepes
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Trends Neurosci 32:48-55. 2009
    ..Here, the best studied pathways of tPA neurotoxicity are discussed along with future directions for a safer use of tPA as a thrombolytic agent in the setting of acute ischemic stroke...
  50. ncbi Primary prevention of stroke by healthy lifestyle
    Stephanie E Chiuve
    Harvard School of Public Health, Department of Nutrition, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 118:947-54. 2008
    ..The combination of healthy lifestyle factors is associated with lower risk of coronary heart disease, diabetes, and total cardiovascular disease. Little is known about the impact of multiple lifestyle factors on the risk of stroke...
  51. ncbi Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats
    Yu Hasegawa
    Department of Physiology, Loma Linda University School of Medicine, Loma Linda, Calif 92354, USA
    Stroke 41:368-74. 2010
    ..FTY720 is a known sphingosine 1-phosphate receptor agonist. In the present study, we investigated the neuroprotective effect of postischemic administration of FTY720 in rats with 2 hours transient middle cerebral artery occlusion (MCAO)...
  52. ncbi Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase
    Chandramohan Wakade
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    Endocrinology 149:367-79. 2008
    ....
  53. ncbi Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils
    S Gupta
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali Punjab
    Indian J Physiol Pharmacol 51:62-8. 2007
    ..This study demonstrates the neuroprotective effect of pifithrin-alpha in global cerebral ischemia in gerbils...
  54. ncbi Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia
    N Shioda
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba Aoba ku, Sendai 980 8578, Japan
    Neuroscience 148:221-9. 2007
    ..B (Akt) signaling through inhibition of protein tyrosine phosphatases, thereby eliciting neuroprotection in brain ischemia/reperfusion injury...
  55. ncbi Therapeutic hypothermia: neuroprotective mechanisms
    Liping Liu
    Dept of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, Neurology 127, 4150 Clement St, San Francisco, CA 94121, USA
    Front Biosci 12:816-25. 2007
    ..Therapeutic hypothermia is likely to undergo phase III clinical trials in various clinical settings. Novel technologies are being developed to optimize the safety and efficacy of this promising approach...
  56. ncbi Inosine reduces ischemic brain injury in rats
    Hui Shen
    National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Stroke 36:654-9. 2005
    ..CONCLUSIONS: Inosine inhibits glutamate postsynaptic responses and reduces cerebral infarction. Its protective effect against ischemia/reperfusion-related insults may involve activation of adenosine A3 receptors...
  57. ncbi Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats
    Michelle Ploughman
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Stroke 40:1490-5. 2009
    ..We tested this hypothesis by evaluating the contribution of BDNF to motor skill relearning after endothelin-1-induced middle cerebral artery occlusion in rats...
  58. ncbi In vivo monitoring of macrophage infiltration in experimental ischemic brain lesions by magnetic resonance imaging
    Christoph Kleinschnitz
    Department of Neurology, , Germany
    J Cereb Blood Flow Metab 23:1356-61. 2003
    ..In conclusion, we have shown by in vivo monitoring that macrophages enter photothrombotic infarcts at late stages of infarct development, suggesting a role in tissue remodeling rather than neuronal injury...
  59. ncbi Animal models of focal and global cerebral ischemia
    Richard J Traystman
    Department of Anesthesiology/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    ILAR J 44:85-95. 2003
    ..This review summarizes many (but not all) small and large animal models of focal and global cerebral ischemia and discusses their advantages and disadvantages...
  60. ncbi Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Brain Res 1262:100-8. 2009
    ..Specifically, TLR4 contributes to cerebral I/R injury, while TLR2 appears to be neuroprotective by enhancing the activation of protective signaling in response to cerebral I/R...
  61. ncbi A pilot study of normobaric oxygen therapy in acute ischemic stroke
    Aneesh B Singhal
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 36:797-802. 2005
    ..Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke...
  62. ncbi Protein kinase C delta mediates cerebral reperfusion injury in vivo
    Rachel Bright
    Department of Molecular Pharmacology, Stanford Stroke Center, Stanford University School of Medicine, Stanford, California 94305-5174, USA
    J Neurosci 24:6880-8. 2004
    ..These data support a deleterious role for deltaPKC during reperfusion and suggest that deltaV1-1 delivery, even hours after commencement of reperfusion, may provide a therapeutic advantage after cerebral ischemia...
  63. ncbi Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis
    Chun-Fang Xia
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Hum Gene Ther 17:206-19. 2006
    ..These results indicate that delayed systemic administration of the kallikrein gene after onset of stroke protects against ischemic brain injury by inhibiting apoptosis and inflammation and by promoting angiogenesis and neurogenesis...
  64. ncbi Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke
    Livia S Machado
    Program in Clinical and Experimental Therapeutics, Clinical Pharmacy Department, College of Pharmacy, University of Georgia, Augusta, GA, USA
    BMC Neurosci 7:56. 2006
    ..Minocycline inhibits inflammation, apoptosis and extracellular matrix degradation. In this study we investigated whether delayed minocycline inhibits brain MMPs activated by ischemia in a model of temporary occlusion in Wistar rats...
  65. ncbi The metabolism of C-glucose by neurons and astrocytes in brain subregions following focal cerebral ischemia in rats
    Anna E Thoren
    Centre for Neuroscience and Department of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, Australia
    J Neurochem 97:968-78. 2006
    ..These findings indicate the presence of complex changes in energy metabolism that are likely to greatly influence the responses of neurons and astrocytes to temporary focal ischemia...
  66. ncbi The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain
    Yi Zhao
    Institute of Pharmacology, University Hospital of Schleswig-Holstein, Campus Kiel, Hospitalstrasse 4, 24105 Kiel, Germany
    Eur J Neurosci 22:278-82. 2005
    ..Our data demonstrate for the first time that it is the activation of intracerebral PPARgamma that can confer neuroprotection, anti-inflammatory and neurological improvement following ischaemic injury...
  67. ncbi Experimental therapy with tissue kallikrein against cerebral ischemia
    Julie Chao
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Front Biosci 11:1323-7. 2006
    ..These findings also raise the possibility that tissue kallikrein may have value in the treatment of acute ischemic stroke...
  68. ncbi Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action
    Hyeon Ju Kim
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, Building 10, Bethesda, MD 20892 1363, USA
    J Pharmacol Exp Ther 321:892-901. 2007
    ..Given that there is no effective treatment for stroke, HDAC inhibitors, such as VPA, SB, and TSA, should be evaluated for their potential use for clinical trials in stroke patients...
  69. ncbi Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia
    Daniela Giuliani
    Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy
    Endocrinology 147:1126-35. 2006
    ..Together, our findings suggest that MC4 receptor-stimulating melanocortins might provide potential to develop a class of drugs with a broad treatment window for a novel approach to neuroprotection in ischemic stroke...
  70. ncbi The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo
    Nathalie Lebeurrier
    INSERM Avenir, tPA in the working brain, GIP Cyceron, Universite de Caen, GIP Cyceron Bd Henri Becquerel, 14074 Caen Cedex, France
    Mol Cell Neurosci 30:552-8. 2005
    ..Altogether, these data suggest that an overexpression of neuroserpin in the brain parenchyma might limit the deleterious effect of tPA on NMDA receptor-mediated neuronal death, which occurs following experimental ischemia...
  71. ncbi Protecting neurons
    Donna M Ferriero
    University of California, San Francisco, Department of Neurology, San Francisco, California 94143 0663, USA
    Epilepsia 46:45-51. 2005
    ..At this time, however, the postinjury enhancement of neurogenesis appears to offer the best hope for long-lasting functional recovery following brain injury...
  72. ncbi The effects of AMPA receptor antagonists in models of stroke and neurodegeneration
    Pierre Gressens
    , , , 75019 Paris, France
    Eur J Pharmacol 519:58-67. 2005
    ..In contrast, GYKI 52466 did not antagonize cortical and white matter damage induced by ibotenic acid. These models allow quantification of the effects of AMPA receptor antagonists in vitro and in vivo...
  73. ncbi Overexpression of PrPC by adenovirus-mediated gene targeting reduces ischemic injury in a stroke rat model
    Woei Cherng Shyu
    Department of Neurology, Neuro Medical Scientific Center, Tzu Chi Buddhist General Hospital, Tzu Chi University, Hualien, 970, Taiwan
    J Neurosci 25:8967-77. 2005
    ..This study suggests that PrPC has physiological relevance to cerebral ischemic injury and could be useful as a therapeutic target for the treatment of cerebral ischemia...
  74. ncbi Extended therapeutic window and functional recovery after intraarterial administration of neuregulin-1 after focal ischemic stroke
    Zhenfeng Xu
    Department of Anatomy and Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Cereb Blood Flow Metab 26:527-35. 2006
    ..These results indicate that NRG-1 is a potent neuroprotective compound with an extended therapeutic window that has practical therapeutic potential in treating individuals after ischemic brain injury...
  75. ncbi Thrombolysis and neuroprotection in cerebral ischemia
    M Gutierrez
    Cerebrovascular Research Group, Hospital Universitario La Paz, Universidad Autonoma Madrid, Spain
    Cerebrovasc Dis 21:118-26. 2006
    ....
  76. ncbi Carnosine is neuroprotective against permanent focal cerebral ischemia in mice
    G K Rajanikant
    Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48824, USA
    Stroke 38:3023-31. 2007
    ..The purposes of this study were to determine whether carnosine is neuroprotective in permanent focal cerebral ischemia and to determine potential mechanisms of neuroprotection...
  77. ncbi Effect of combination of endothelin receptor antagonist (TAK-044) and aspirin in middle cerebral artery occlusion model of acute ischemic stroke in rats
    S Briyal
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
    Methods Find Exp Clin Pharmacol 29:257-63. 2007
    ..The present study demonstrates that, although protection was observed with both the drugs (TAK-044 and aspirin), there was no enhanced effect when both agents were given in combination...
  78. ncbi EndothelinA receptor antagonist BSF-208075 causes immune modulation and neuroprotection after stroke in gerbils
    Erik F Hauck
    Division of Neurosurgery, University of Texas Medical Branch, Galveston, USA
    Brain Res 1157:138-45. 2007
    ..05). Conclusion: Endothelins mediate leukocyte activation in ischemic stroke. The endothelinA receptor antagonist BSF-208075 administered during reperfusion reduces the postischemic leukocyte activation and causes neuroprotection...
  79. ncbi Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia
    Jun Li
    Department of Neurology and Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, United States
    Neurosci Lett 438:210-5. 2008
    ..Taken together, these findings suggest a novel function for misoprostol as a protective agent in cerebral ischemia acting via the PGE(2) EP2 and/or EP4 receptors...
  80. ncbi A novel voltage-sensitive Na(+) and Ca(2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat
    Kortaro Tanaka
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 924:98-108. 2002
    ..These data clearly indicate that NS-7 provides very efficient neuroprotection in the acute phase of cerebral ischemia, and sustains the normal function of PKA...
  81. ncbi Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia
    Ran Liu
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Neurosci Lett 415:237-41. 2007
    ..These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window...
  82. ncbi Comparison between early and delayed systemic treatment with candesartan of rats after ischaemic stroke
    Jan Brdon
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Hypertens 25:187-96. 2007
    ..The effects of candesartan treatment starting early (3 h) and delayed (24 h) after middle cerebral artery occlusion (MCAO) with reperfusion was investigated in normotensive rats...
  83. ncbi Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia
    Zhengyan Liu
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94121, USA
    Stroke 38:146-52. 2007
    ..The aim of this current study is to determine the effect of minocycline on neurogenesis and functional recovery after cerebral focal ischemia...
  84. ncbi Olanzapine attenuates brain damage after focal cerebral ischemia in vivo
    Burak Yulug
    Department of Neurology, University of Uludag Bursa, Turkey
    Brain Res Bull 71:296-300. 2006
    ..Twenty-four hours after permanent ischemia, brain injury was evaluated by triphenyltetrazolium chloride staining (TTC). Olanzapine (0.1 and 1 mg/kg) showed significant neuroprotection after permanent focal cerebral ischemia...
  85. ncbi Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat
    I Solaroglu
    Department of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, CA, USA
    Neuroscience 143:965-74. 2006
    ..These changes were associated with remarkable improvement in tissue preservation and behavioral outcome...
  86. ncbi Humanin is a novel neuroprotective agent against stroke
    Xingshun Xu
    Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Stroke 37:2613-9. 2006
    ..HNG offers neuroprotection in vivo at least in part by inhibiting ERK activation. These findings suggest a potential therapeutic role for HNG in the treatment of stroke...
  87. ncbi Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits
    Amir Oron
    Department of Orthopedics, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Stroke 37:2620-4. 2006
    ..Low-level laser therapy (LLLT) modulates various biological processes. In the present study, we assessed the hypothesis that LLLT after induction of stroke may have a beneficial effect on ischemic brain tissue...
  88. ncbi NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke
    Alyson A Miller
    Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
    Brain Res 1111:111-6. 2006
    ..Additionally, NADPH-oxidase activity is temporarily enhanced after cerebral ischemia within arteries from non-ischemic parts of the brain...
  89. ncbi Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats
    Heng Zhao
    Department of Neurosurgery, Stanford University, California 94305 5327, USA
    J Cereb Blood Flow Metab 26:1114-21. 2006
    ..In conclusion, postconditioning reduced infarct size, most plausibly by blocking apoptosis and free radical generation. With further study it may eventually be clinically applicable for stroke treatment...
  90. ncbi Intracarotid injection of granulocyte-macrophage colony-stimulating factor induces neuroprotection in a rat transient middle cerebral artery occlusion model
    Toru Nakagawa
    Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    Brain Res 1089:179-85. 2006
    ..These results suggest that intracarotid injection of GM-CSF may have a therapeutic effect on brain ischemia via activation of microglia/macrophages.
  91. ncbi Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat
    Preeti Dohare
    Division of Pharmacology, Central Drug Research Institute, Lucknow 226001, India
    Behav Brain Res 193:289-97. 2008
    ....
  92. ncbi Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain
    C Manabat
    Department of Neurology, University of California at San Francisco, 94143-0114, USA
    Stroke 34:207-13. 2003
    ..Furthermore, persistent perfusion deficits result in less caspase-3 activation and appear to favor caspase-independent injury...
  93. ncbi Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis
    Chun-Fang Xia
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 43:452-9. 2004
    ....
  94. ncbi Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats
    Meenakshisundaram Thiyagarajan
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160 062, Punjab, India
    Life Sci 74:969-85. 2004
    ..These results suggest the neuroprotective potential of curcumin in cerebral ischemia and is mediated through its antioxidant activity...
  95. ncbi Neuroprotection by tempol in a model of iron-induced oxidative stress in acute ischemic stroke
    Shyamal H Mehta
    Dept. of Physiology, Medical College of Georgia, 1120 15th St, CL2122, Augusta, GA 30912, USA
    Am J Physiol Regul Integr Comp Physiol 286:R283-8. 2004
    ..We propose that iron-induced ROS generation in the cerebral vasculature adds to oxidative stress during an ischemic episode after the disruption of the blood-brain barrier...
  96. ncbi The effect of bone morphogenetic protein-7 (BMP-7) on functional recovery, local cerebral glucose utilization and blood flow after transient focal cerebral ischemia in rats
    Y Liu
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
    Brain Res 905:81-90. 2001
    ..0003). Compared to vehicle-rats, BMP-7 enhanced glucose utilization in the basal ganglia ipsilateral to stroke and improved LCBF in ipsilateral subthalamus, but decreased LCBF and LCMRglu in contralateral cortical regions...
  97. ncbi Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states
    Mary P Stenzel-Poore
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Lancet 362:1028-37. 2003
    ..We developed a mouse model of neuroprotection in stroke and did gene expression profiling to identify potential neuroprotective genes and their associated pathways...
  98. ncbi Diadenosine tetraphosphate protects against injuries induced by ischemia and 6-hydroxydopamine in rat brain
    Yun Wang
    National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 23:7958-65. 2003
    ..We propose that AP4A may be a potentially useful target molecule in the therapy of stroke and Parkinson's disease...
  99. ncbi Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia
    H Imai
    Wellcome Surgical Institute and Department of Neuropathology, University of Glasgow, Glasgow, Scotland
    Stroke 32:2149-54. 2001
    ..The reduction in tissue displaying evidence of oxidative stress suggests that the major mechanism of action is attenuation of free radical damage...
  100. ncbi Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons
    M Endres
    Experimental Neurology, Department of Neurology, Charite Hospital, Humboldt University, Schumannstr 20 21, D 10098 Berlin, Germany
    Neuroreport 12:3763-6. 2001
    ..In conclusion, we demonstrate that reduced levels of Dnmt1, but not its absence, in post-mitotic neurons protect from ischemic brain injury...
  101. ncbi Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia
    Hiroyuki Takamatsu
    The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama cho, Hakui Shi, Ishikawa, 925 0613, Japan
    Brain Res 925:176-82. 2002
    ..The present study demonstrated that the intravenous application of a central type prostacyclin receptor ligand could be a novel therapeutic agent for acute stroke...

Research Grants83

  1. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 2002
    ..P-glycoprotein and the organic acid transporter both play a major role in limiting the access of some drugs to the brain. ..
  2. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN FADEN; Fiscal Year: 2009
    ....
  3. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
    ....
  4. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1993
    ....
  5. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D RICHARD MILNER; Fiscal Year: 2010
    ..If successful, this work could have major impact on the incidence and mortality of ischemic stroke. ..
  6. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D Milner; Fiscal Year: 2009
    ..If successful, this work could have major impact on the incidence and mortality of ischemic stroke. ..
  7. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2007
    ....
  8. Blood-Brain Barrier in Cerebral Ischemia
    MARTHA O DONNELL; Fiscal Year: 2005
    ..The proposed studies should reveal whether therapeutic approaches aimed at blocking BBB Na-K-Cl cotransporter activity may be of value for attenuating ischemia-induced brain edema. ..
  9. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2010
    ..The application's objectives are to explore the feasibility for further clinical trials of combination therapy of estrogen and rtPA for ischemic stroke. ..
  10. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2009
    ..The application's objectives are to explore the feasibility for further clinical trials of combination therapy of estrogen and rtPA for ischemic stroke. ..
  11. Pilot Trial of Bumetanide for Neonatal Seizures
    JANET SUSAN SOUL; Fiscal Year: 2010
    ..The proposed pilot trial will determine the feasibility of a novel trial design to test new drugs to treat seizures in newborns, and will determine the pharmacokinetics and safety of bumetanide in newborns. ..
  12. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  13. Heat Shock Protein Therapeutics for Stroke
    FRANK R contact SHARP; Fiscal Year: 2010
    ....
  14. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2010
    ..The studies proposed will provide new insight on the mechanism of vascular dementia and identify potential therapeutic target for the prevention of cognitive decline following cerebral ischemia. ..
  15. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    ..abstract_text> ..
  16. Mechanisms of Hyperbaric Oxygen Induced Brain Protection
    John H Zhang; Fiscal Year: 2010
    ....
  17. Cytokines and the blood-brain barrier in the ovine fetus
    Barbara S Stonestreet; Fiscal Year: 2010
    ..b>Brain ischemia is induced by carotid occlusion...
  18. Cytokines and the blood-brain barrier in the ovine fetus
    BARBARA STONESTREET; Fiscal Year: 2009
    ..b>Brain ischemia is induced by carotid occlusion...
  19. Cytokines and the blood-brain barrier in the ovine fetus
    Barbara S Stonestreet; Fiscal Year: 2010
    ..b>Brain ischemia is induced by carotid occlusion...
  20. Cytokines and the blood-brain barrier in the ovine fetus
    BARBARA STONESTREET; Fiscal Year: 2009
    ..b>Brain ischemia is induced by carotid occlusion...
  21. Cerebal Ischemia During Anesthesia and Surgery
    Piyush Patel; Fiscal Year: 2004
    ..The long term goals of the research are to prevent the occurrence of isehemic brain injury in patients undergoing anesthesia and surgery. ..
  22. Nitric Oxide--Neurotoxic Mechanisms of MPTP
    Allen Mandir; Fiscal Year: 2002
    ..In this study we demonstrate that NMDA excitotoxicity is dramatically reduced in PARP-1 knockout mice whereas PARP-1 knockout mice are sensitive to AMPA excitotoxicity. ..
  23. Jun Kinase Signaling and Apoptosis in Ischemia Stroke
    Chia Yi Kuan; Fiscal Year: 2006
    ..Finally, we will use tw0-dimensional protein electrophoresis of mass spectrometry to identify the mitochondrial targets of JNK signaling. ..
  24. A NEW STRATEGY FOR PROTECTION FROM CEREBRAL ISCHEMIA
    Ying Xia; Fiscal Year: 2009
    ..Our preliminary studies have shown that this proposal is feasible and will very likely yield important information on the EA-induced protection and eventually shed light on new therapeutic modalities of stroke. ..
  25. A NEW STRATEGY FOR PROTECTION FROM CEREBRAL ISCHEMIA
    Ying Xia; Fiscal Year: 2010
    ..Our preliminary studies have shown that this proposal is feasible and will very likely yield important information on the EA-induced protection and eventually shed light on new therapeutic modalities of stroke. ..
  26. INFLAMMATORY AND THROMBOTIC CELL INTERACTIONS IN STROKE
    Leslie Ritter; Fiscal Year: 2000
    ....
  27. Neonatal Brain Ischemia: Neuroimaging as a Basis For Rational Stem Cell Therapy
    Stephen Ashwal; Fiscal Year: 2010
    ....
  28. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2007
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..
  29. Neonatal Brain Ischemia: Neuroimaging as a Basis For Rational Stem Cell Therapy
    Stephen Ashwal; Fiscal Year: 2009
    ....
  30. NMDA ANTAGONISTS IN THE TREATMENT OF STROKE
    Gary Steinberg; Fiscal Year: 1993
    ..The results from the proposed project will expedite the planning and execution of a clinical study...
  31. Radical Scavengers for Brain Ischemia Reperfusion injury
    Howard Elford; Fiscal Year: 2003
    ..Imidate have exhibited biochemical properties that indicate that they are good candidates to protect against brain ischemia reperfusion injury. These compounds are very effective free radical scavengers...