cerebrovascular disorders

Summary

Summary: A broad category of disorders characterized by impairment of blood flow in the arteries and veins which supply the brain. These include CEREBRAL INFARCTION; BRAIN ISCHEMIA; HYPOXIA, BRAIN; INTRACRANIAL EMBOLISM AND THROMBOSIS; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; and VASCULITIS, CENTRAL NERVOUS SYSTEM. In common usage, the term cerebrovascular disorders is not limited to conditions that affect the cerebrum, but refers to vascular disorders of the entire brain including the DIENCEPHALON; BRAIN STEM; and CEREBELLUM.

Top Publications

  1. doi High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities
    Paola Michelozzi
    Department of Epidemiology Local Health Authority Rome E, Rome, Italy
    Am J Respir Crit Care Med 179:383-9. 2009
  2. pmc Vascular pathology in the aged human brain
    Lea Tenenholz Grinberg
    Department of Neurology, University of California San Francisco, 305 Parnassus Avenue, San Francisco, CA 94143, USA
    Acta Neuropathol 119:277-90. 2010
  3. pmc Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    Robert D Bell
    Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Acta Neuropathol 118:103-13. 2009
  4. ncbi Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndrome
    W S Bartynski
    Department of Radiology, Division of Neuroradiology, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    AJNR Am J Neuroradiol 28:1320-7. 2007
  5. pmc Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS
    K Kantarci
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Neurology 72:1519-25. 2009
  6. ncbi A clinical comparison of definite moyamoya disease between South Korea and Japan
    K Ikezaki
    Department of Neurosurgery, Kyushu University Faculty of Medicine, Fukuoka, Japan
    Stroke 28:2513-7. 1997
  7. doi Vitamin D status and the risk of cardiovascular disease death
    Annamari Kilkkinen
    National Institute for Health and Welfare, Helsinki, Finland
    Am J Epidemiol 170:1032-9. 2009
  8. ncbi White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Austria
    Ann Neurol 58:610-6. 2005
  9. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
  10. ncbi Brain hypoperfusion: a critical factor in vascular dementia
    Gustavo C Roman
    University of Texas Health Science Center at San Antonio and the Audie L Murphy Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, San Antonio, USA
    Neurol Res 26:454-8. 2004

Detail Information

Publications234 found, 100 shown here

  1. doi High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities
    Paola Michelozzi
    Department of Epidemiology Local Health Authority Rome E, Rome, Italy
    Am J Respir Crit Care Med 179:383-9. 2009
    ..Episode analyses of heat waves have documented a comparatively higher impact on mortality than on morbidity (hospital admissions) in European cities. The evidence from daily time series studies is scarce and inconsistent...
  2. pmc Vascular pathology in the aged human brain
    Lea Tenenholz Grinberg
    Department of Neurology, University of California San Francisco, 305 Parnassus Avenue, San Francisco, CA 94143, USA
    Acta Neuropathol 119:277-90. 2010
    ....
  3. pmc Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    Robert D Bell
    Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Acta Neuropathol 118:103-13. 2009
    ..The data reviewed here support an essential role of neurovascular and BBB mechanisms in contributing to both, onset and progression of AD...
  4. ncbi Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndrome
    W S Bartynski
    Department of Radiology, Division of Neuroradiology, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    AJNR Am J Neuroradiol 28:1320-7. 2007
    ..We evaluated lesion distribution with CT and MR in a large cohort of patients who experienced PRES to comprehensively assess the imaging patterns identified...
  5. pmc Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS
    K Kantarci
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Neurology 72:1519-25. 2009
    ..To investigate the combined ability of hippocampal volumes, 1H magnetic resonance spectroscopy (MRS) metabolites, and cerebrovascular disease to predict the risk of progression to dementia in mild cognitive impairment (MCI)...
  6. ncbi A clinical comparison of definite moyamoya disease between South Korea and Japan
    K Ikezaki
    Department of Neurosurgery, Kyushu University Faculty of Medicine, Fukuoka, Japan
    Stroke 28:2513-7. 1997
    ..The goal of the present study was to clarify whether South Korean patients with moyamoya disease have clinical features similar to those of Japanese patients...
  7. doi Vitamin D status and the risk of cardiovascular disease death
    Annamari Kilkkinen
    National Institute for Health and Welfare, Helsinki, Finland
    Am J Epidemiol 170:1032-9. 2009
    ..These findings need to be replicated in other populations. To demonstrate a causal link between vitamin D and CVD, randomized controlled trials are required...
  8. ncbi White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Austria
    Ann Neurol 58:610-6. 2005
    ....
  9. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  10. ncbi Brain hypoperfusion: a critical factor in vascular dementia
    Gustavo C Roman
    University of Texas Health Science Center at San Antonio and the Audie L Murphy Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, San Antonio, USA
    Neurol Res 26:454-8. 2004
    ..Recognition of the susceptibility of elderly subjects to cerebral lesions induced by hypoperfusion should result in appropriate preventive measures and better treatment...
  11. doi The Essen stroke risk score predicts recurrent cardiovascular events: a validation within the REduction of Atherothrombosis for Continued Health (REACH) registry
    Christian Weimar
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Stroke 40:350-4. 2009
    ..We aimed to validate the ESRS in a large cohort of outpatients with previous transient ischemic attack or stroke from the REduction of Atherothrombosis for Continued Health (REACH) Registry...
  12. ncbi Urban air pollution and emergency admissions for cerebrovascular diseases in Taipei, Taiwan
    Chang Chuan Chan
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Rm 722, 7F, No 17, Xu Zhou Road, Taipei 100, Taiwan, ROC
    Eur Heart J 27:1238-44. 2006
    ..This study was designed to evaluate the association between urban air pollutants and emergency admissions for cerebrovascular diseases...
  13. ncbi Incidence and short-term prognosis of transient ischemic attack in a population-based study
    Dawn Kleindorfer
    Department of Emergency Medicine, University of Cincinnati, Ohio, USA
    Stroke 36:720-3. 2005
    ..We present the incidence and short-term prognosis of TIA within a large population with a significant proportion of minorities with out-of-hospital TIA...
  14. ncbi MRI white matter hyperintensities: three-year follow-up of the Austrian Stroke Prevention Study
    R Schmidt
    Department of Neurology, Institute of Medical Biochemistry, Karl Franzens University, Graz, Austria
    Neurology 53:132-9. 1999
    ..To determine the rate, clinical predictors, and cognitive consequences of MRI white matter hyperintensity evolution over 3 years...
  15. doi 4-D Imaging in cerebrovascular disorders by using 320-slice CT: feasibility and preliminary clinical experience
    Randolf Klingebiel
    Department of Neuroradiology, Charite, University Medicine Berlin, Berlin, Germany
    Acad Radiol 16:123-9. 2009
    The authors report study protocols and initial clinical experience in assessing patients with acute and chronic cerebrovascular disorders using the recently introduced technique of volume computed tomography (VCT).
  16. ncbi Cerebrovascular disease and dementia
    Chiadi U Onyike
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int Rev Psychiatry 18:423-31. 2006
    ..Our knowledge of the risk factors has also provided opportunities for the primary and secondary prevention of vascular dementia, and indicates promising avenues for research...
  17. doi 5-year outcomes following percutaneous coronary intervention with drug-eluting stent implantation versus coronary artery bypass graft for unprotected left main coronary artery lesions the Milan experience
    Alaide Chieffo
    Interventional Cardiology Unit, Department of Cardio Thoracic and Vascular Diseases, San Raffaele Scientific Institute, Milan, Italy
    JACC Cardiovasc Interv 3:595-601. 2010
    ....
  18. doi Hypertension and cerebrovascular damage
    Franco Veglio
    University of Turin, Italy
    Atherosclerosis 205:331-41. 2009
    ..Cerebral parenchymal and functional damages have to be considered together to make medical intervention more incisive...
  19. ncbi Agalsidase-beta therapy for advanced Fabry disease: a randomized trial
    Maryam Banikazemi
    Mount Sinai School of Medicine of New York University, New York, New York, USA
    Ann Intern Med 146:77-86. 2007
    ..Fabry disease (alpha-galactosidase A deficiency) is a rare, X-linked lysosomal storage disorder that can cause early death from renal, cardiac, and cerebrovascular involvement...
  20. pmc Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators
    Narayan R Bhat
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 115:551-62. 2010
    ....
  21. ncbi Females with Fabry disease frequently have major organ involvement: lessons from the Fabry Registry
    William R Wilcox
    Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd SSB, Los Angeles, CA 90048, USA
    Mol Genet Metab 93:112-28. 2008
    ..Thus, females with FD have a significant risk for major organ involvement and decreased QoL. Females should be regularly monitored for signs and symptoms of FD, and considered for enzyme replacement therapy...
  22. doi Repetitive use of intra-arterial verapamil in the treatment of reversible cerebral vasoconstriction syndrome
    Kris F French
    Department of Neurology and Clinical Neurosciences, Clinical Neurosciences Center, University of Utah Hospitals and Clinics, 175 N Medical Drive East, Salt Lake City 84132, UT, USA
    J Clin Neurosci 19:174-6. 2012
    ....
  23. doi Fish consumption and the incidence of cerebrovascular disease
    Jukka Montonen
    Department of Health and Functional Capacity, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Br J Nutr 102:750-6. 2009
    ..The relationship between fish consumption and stroke risk is not straightforward. How the fish is prepared for consumption may play an important role, affecting the association...
  24. pmc All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort study
    Rosa Liperoti
    Centro di Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8 0168 Rome, Italy
    J Clin Psychiatry 70:1340-7. 2009
    ..We conducted a retrospective cohort study to compare the risk of death associated with atypical and conventional antipsychotics in a large population of nursing home residents with dementia...
  25. ncbi Alzheimer’s disease, cerebrovascular disease, and the β-amyloid cascade
    Kie Honjo
    L C Campbell Cognitive Neurology Research Unit Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada
    Can J Neurol Sci 39:712-28. 2012
    ..In this review, we review the role of vascular factors and Aβ, underlining that vascular risk factor management may be important for AD prevention and treatment...
  26. ncbi Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease
    Hector H Palacios
    Department of Biology, College of Sciences, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 1664, USA
    CNS Neurol Disord Drug Targets 10:149-62. 2011
    ....
  27. ncbi Genetics of cerebrovascular disorders
    James F Meschia
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
    Mayo Clin Proc 80:122-32. 2005
    ..This article reviews the clinical and genetic features of some mendellan and mitochondrial disorders associated with ischemic stroke, hemorrhagic stroke, and cerebrovascular malformations...
  28. doi Treatment of vascular risk factors is associated with slower decline in Alzheimer disease
    Yan Deschaintre
    Universite Lille Nord de France, INSERM UMR 744, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    Neurology 73:674-80. 2009
    ..The aim of this observational study was to evaluate whether the treatment of VRF is associated with a slower cognitive decline in patients who have AD without cerebrovascular disease (CVD)...
  29. doi Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk
    R Takechi
    School of Public Health, Curtin Health Innovation Research Institute, Australian Technology Network Centre for Metabolic Fitness, Curtin University of Technology, Bentley Campus, Kent Street, Perth 6102, Australia
    Prog Lipid Res 49:159-70. 2010
    ..Clearly, delineating the mechanisms by which dietary fats increase AD risk may be informative in developing new strategies for prevention and treatment of AD...
  30. doi Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice
    Hiroshi Kitaguchi
    Department of Neurology, Kyoto University, Sakyo ku, Kyoto 606 8504, Japan
    Brain Res 1294:202-10. 2009
    ..Taken together, chronic cerebral hypoperfusion increased Abeta fibrils and induced Abeta deposition in the intracellular compartment and, therefore, may accelerate the pathological changes of Alzheimer's disease...
  31. ncbi Cerebrovascular disorders in children
    John Kylan Lynch
    Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, NIH DHHS, Building 10, Room 5S220, 10 Center Drive, MSC 1447, Bethesda, MD 20892 1447, USA
    Curr Neurol Neurosci Rep 4:129-38. 2004
    b>Cerebrovascular disorders are an important cause of mortality and chronic morbidity in children. International incidence rates for childhood stroke (ie, from 30 days to 18 years of age) have ranged from 1.3 to 13 per 100,000 children...
  32. ncbi Cardiovascular epidemiology in the Asia-Pacific region
    G L Khor
    Department of Nutrition and Health Sciences, Faculty, of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang
    Asia Pac J Clin Nutr 10:76-80. 2001
    ..Thus, monitoring the impact of these changes on cardiovascular risks is essential to enable the implementation of appropriate strategies towards countering the rise of CVD mortality...
  33. doi Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist
    Nektaria Nicolakakis
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurosci 28:9287-96. 2008
    ....
  34. doi Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review
    Atticus H Hainsworth
    Centre for Clinical Neuroscience, Division of Cardiac and Vascular Sciences, St George s University of London, London, UK
    J Cereb Blood Flow Metab 28:1877-91. 2008
    ..The most-used model was the stroke-prone spontaneously hypertensive rat (SHR-SP). No model described all features of the human disease. The optimal choice of model depends on the aspect of pathophysiology being studied...
  35. ncbi Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study
    W T Longstreth
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 27:1274-82. 1996
    ..Our aim was to identify potential risk factors for and clinical manifestations of white matter findings on cranial MRI in elderly people...
  36. doi Prior polyvascular disease: risk factor for adverse ischaemic outcomes in acute coronary syndromes
    Deepak L Bhatt
    VA Boston Healthcare System and Brigham and Women s Hospital, Boston, MA, USA
    Eur Heart J 30:1195-202. 2009
    ....
  37. ncbi Alzheimer disease as a vascular disorder: nosological evidence
    J C de La Torre
    Department of Neuropathology, University of California at San Diego, CA 92026, USA
    Stroke 33:1152-62. 2002
    ..The main stumbling block in the clinical management and in the search for a cure of Alzheimer disease (AD) is that the cause of this disorder has remained uncertain until now...
  38. pmc Arterial spin-labeled MR perfusion imaging: clinical applications
    Jeffrey M Pollock
    Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Magn Reson Imaging Clin N Am 17:315-38. 2009
    ..The appearance of pathology is affected significantly by the ASL techniques used. Familiarity with the available sequence parameter options and the common appearances of pathology facilitates perfusion interpretation...
  39. doi Circulating vitamin D, calcium and risk of cerebrovascular disease: a systematic review and meta-analysis
    Rajiv Chowdhury
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Epidemiol 27:581-91. 2012
    ..Conversely, higher circulating calcium concentration is associated with an increased risk of cerebrovascular disease...
  40. ncbi Long-term safety and cognitive effects of galantamine in the treatment of probable vascular dementia or Alzheimer's disease with cerebrovascular disease
    A F Kurz
    Department of Psychiatry and Psychotherapy, Technische Universitaet Munchen, Munich, Germany
    Eur J Neurol 10:633-40. 2003
    ..Long-term (up to 24 months) galantamine therapy in patients with VaD and AD with CVD is well tolerated and associated with prolonged maintenance of cognitive function...
  41. pmc Age and apoE associations with complex pathologic features in Alzheimer's disease
    Gregory A Jicha
    Department of Neurology, Mayo Clinic, Rochester, MN, Jacksonville, FL, United States
    J Neurol Sci 273:34-9. 2008
    ....
  42. doi Comparison of coronary artery bypass surgery and percutaneous drug-eluting stent implantation for treatment of left main coronary artery stenosis
    Anthony J White
    Cedars Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California 90048, USA
    JACC Cardiovasc Interv 1:236-45. 2008
    ..The purpose of this study was to compare outcomes for drug-eluting stents (DES) and coronary artery bypass graft (CABG) surgery in patients with unprotected left main coronary artery (ULMCA) stenosis...
  43. ncbi Progression of cerebral white matter lesions -- clinical and radiological considerations
    Christian Enzinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 257:5-10. 2007
    ..Power calculations based on quantitative data of the Austrian Stroke Prevention Study (ASPS) suggest that such studies would be feasible...
  44. ncbi Calcium and magnesium in drinking water and risk of death from cerebrovascular disease
    C Y Yang
    School of Public Health, Kaohsiung Medical College, Taiwan, Republic of China
    Stroke 29:411-4. 1998
    ..This report examines whether calcium and magnesium in drinking water are protective against cerebrovascular disease...
  45. ncbi Prior peripheral arterial disease and cerebrovascular disease are independent predictors of adverse outcome in patients with acute coronary syndromes: are we doing enough? Results from the Orbofiban in Patients with Unstable Coronary Syndromes-Thrombolysi
    Gad Cotter
    Cardiology Institutes of Assaf Harofeh Medical Center, Zerifin, Israel
    Am Heart J 145:622-7. 2003
    ....
  46. doi Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Neurol Sci 287:45-51. 2009
    ..9 were significant predisposing factors for stroke. Patients with CVD and co-existing atherothrombotic diseases had a high risk of recurrent events, including events arising in other vascular beds than originally diagnosed...
  47. ncbi Genetic variation in white matter hyperintensity volume in the Framingham Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, B 609, Boston, Mass 02118, USA
    Stroke 35:1609-13. 2004
    ..73). We investigated heritability of WMH in a family-based sample of the Framingham Heart Study for sex differences and the impact of age...
  48. doi Role of methylenetetrahydrofolate reductase gene (MTHFR) 677C>T polymorphism in pediatric cerebrovascular disorders
    Hamza Alsayouf
    Division of Child Neurology, The Ohio State University, Columbus, Nationwide Children s Hospital, OH 43205, USA
    J Child Neurol 26:318-21. 2011
    ..However, the data suggest that the MTHFR TT genotype may influence migraine susceptibility in children because there was a higher proportion of migraine patients (28.6%) with the MTHFR TT homozygous genotype...
  49. doi Two-year vascular event rates in patients with symptomatic cerebrovascular disease: the REACH registry
    Narayanaswamy Venketasubramanian
    Division of Neurology, National University Hospital, Singapore
    Cerebrovasc Dis 32:254-60. 2011
    ..We describe 2-year vascular outcomes among symptomatic CeVD patients from the REduction of Atherothrombosis for Continued Health (REACH) Registry...
  50. doi Cerebrovascular disorders: molecular insights and therapeutic opportunities
    Erik Storkebaum
    Molecular Neurogenetics Laboratory, Max Planck Institute for Molecular Biomedicine, Muenster, Germany
    Nat Neurosci 14:1390-7. 2011
    ..These genetic insights offer alternative therapeutic options, some of which are being evaluated in the clinic...
  51. pmc Risk estimations, risk factors, and genetic variants associated with Alzheimer's disease in selected publications from the Framingham Heart Study
    Galit Weinstein
    Department of Neurology, Boston University School of Medicine, Boston, MA 20008, USA
    J Alzheimers Dis 33:S439-45. 2013
    ..The second is a large meta-analysis GWA study of AD, in which novel loci of AD susceptibility were found. Together, these findings demonstrate the FHS multi-directional efforts in investigating dementia and AD...
  52. ncbi Neuroimaging in cerebrovascular disorders: measurement of cerebral physiology after stroke and assessment of stroke recovery
    James M Mountz
    Department of Radiology, Division of Nuclear Medicine, University of Alabama at Birmingham Medical Center, Birmingham, AL 35249 6835, USA
    Semin Nucl Med 33:56-76. 2003
    ..The value of these results on rehabilitation strategy, including possible criteria for the use of facilitatory versus compensatory approaches, is analyzed...
  53. ncbi The blood-brain barrier/neurovascular unit in health and disease
    Brian T Hawkins
    Department of Medical Pharmacology, University of Arizona College of Medicine, Tucson, Arizona, USA
    Pharmacol Rev 57:173-85. 2005
    ..Therefore, understanding how BBB TJ might be affected by various factors holds significant promise for the prevention and treatment of neurological diseases...
  54. doi Prediction of cerebral hyperperfusion syndrome after carotid stenting: a cerebral perfusion computed tomography study
    Ying Chi Tseng
    Department of Radiology, Cathay General Hospital, Taipei, Taiwan, Republic of China
    J Comput Assist Tomogr 33:540-5. 2009
    ..The objective of this study was to evaluate the role of cerebral perfusion computed tomography (CT) in predicting cerebral hyperperfusion syndrome (CHS) after carotid stenting...
  55. ncbi Quantitative cerebral blood flow determinations in acute ischemic stroke. Relationship to computed tomography and angiography
    A D Firlik
    Department of Neurological Surgery, University of Pittsburgh Medical Center, PA 15213, USA
    Stroke 28:2208-13. 1997
    ....
  56. ncbi Size fractionate particulate matter, vehicle traffic, and case-specific daily mortality in Barcelona, Spain
    L Perez
    Center for research in environmental epidemiology CREAL, Dr Aiguader 88, 08003 Barcelona, Spain
    Environ Sci Technol 43:4707-14. 2009
    ..Vehicle traffic PM, generated by combustion and noncombustion processes, should be considered in air pollution mitigation strategies in urban areas...
  57. ncbi Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease
    Hiroshi Kitaguchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Neurosci Lett 417:128-31. 2007
    ..Cortical microvascular changes in AD and their absence in BD may indicate a role of beta amyloid for the microvessel pathology in AD...
  58. ncbi Cerebral hyperperfusion syndrome after percutaneous transluminal stenting of the craniocervical arteries
    P M Meyers
    Department of Radiology, University of California at San Francisco, USA
    Neurosurgery 47:335-43; discussion 343-5. 2000
    ..To our knowledge, there are no previous studies evaluating the incidence of hyperperfusion syndrome after percutaneous transluminal angioplasty/stenting...
  59. ncbi Vascular basis of Alzheimer's pathogenesis
    J C de La Torre
    Division of Neuropathology, University of California San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    Ann N Y Acad Sci 977:196-215. 2002
    ....
  60. ncbi The prevalence of peripheral arterial disease in high risk subjects and coronary or cerebrovascular patients
    Pavel Poredos
    Department of Vascular Diseases, University Medical Centre, Ljubljana, Slovenia
    Angiology 58:309-15. 2007
    ..In conclusion, our findings confirm a high prevalence of both symptomatic and asymptomatic PAD in patients at high cardiovascular risk and its association with both CAD and CVD...
  61. doi Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    Eric E Smith
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arch Neurol 65:94-100. 2008
    ..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...
  62. ncbi Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders
    Ryuichi Ohkubo
    Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Neurol Sci 198:31-5. 2002
    ..Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD...
  63. ncbi Alzheimer disease and cerebrovascular pathology: an update
    K A Jellinger
    Ludwig Boltzmann Institute of Clinical Neurobiology, Otto Wagner Hospital, Vienna, Austria
    J Neural Transm 109:813-36. 2002
    ..Further studies will help to elucidate the risk factors and impact of cerebrovascular lesions on the development and progression of dementia in AD...
  64. pmc Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Neurology 59:867-73. 2002
    ..To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI)...
  65. ncbi Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Lancet 359:1283-90. 2002
    ..We investigated the effects of galantamine in patients with a diagnosis of probable vascular dementia or Alzheimer's disease combined with cerebrovascular disease...
  66. ncbi Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
    A Joutel
    INSERM U25, Faculte de Medecine Necker Enfants Malades, Paris, France
    Nature 383:707-10. 1996
    ..We have identified mutations in CADASIL patients that cause serious disruption of this gene, indicating that Notch3 could be the defective protein in CADASIL patients...
  67. ncbi CNS manifestations of Fabry's disease
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Lancet Neurol 5:791-5. 2006
    ..Cerebral vasculopathy, confirmed by neuropathological, neuroradiological, and functional studies, occurs commonly and leads to ischaemic cerebrovascular events at an early age...
  68. ncbi Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    Niels D Prins
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 128:2034-41. 2005
    ..Our results suggest that in older people cerebral small-vessel disease may contribute to cognitive decline by affecting information processing speed and executive function...
  69. ncbi Brain perfusion abnormalities in patients with euthyroid autoimmune thyroiditis
    M Piga
    Nuclear Medicine, Department of Medical Sciences M Aresu, University of Cagliari, Cagliari, Italy
    Eur J Nucl Med Mol Imaging 31:1639-44. 2004
    ..Sixteen adult patients with HT entered this study following informed consent...
  70. pmc Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
    M E Calhoun
    Department of Neuropathology, Institute for Pathology, University of Basel, CH 4003 Basel, Switzerland
    Proc Natl Acad Sci U S A 96:14088-93. 1999
    ..APP23 mice on an App-null background developed a similar degree of both plaques and CAA, providing further evidence that a neuronal source of APP/Abeta is sufficient to induce cerebrovascular amyloid and associated neurodegeneration...
  71. pmc Cerebrovascular disease and stroke
    J Pappachan
    Department of Paediatric Intensive Care, Child Health Directorate, Southampton General Hospital, Southampton, UK
    Arch Dis Child 93:890-8. 2008
    Stroke and cerebrovascular disorders are important causes of morbidity and mortality in children; they are already amongst the top 10 causes of childhood death and are probably increasing in prevalence...
  72. ncbi Prognosis and management of patients with acute coronary syndrome and polyvascular disease
    Ignacio Ferreira-Gonzalez
    Area del Cor, Servicio de Cardiologia, Hospital Vall d Hebron, Barcelona, Espana
    Rev Esp Cardiol 62:1012-21. 2009
    ..To assess prognosis and patterns of care in patients with acute coronary syndrome and peripheral arterial disease (PAD), cerebrovascular disease or both (i.e., polyvascular disease) in everyday clinical practice...
  73. ncbi Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice
    Runa Araya
    Yamada Research Unit, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neurobiol Dis 24:334-44. 2006
    ..The M5 receptor may represent an attractive novel therapeutic target to ameliorate memory deficits caused by impaired cerebrovascular function...
  74. ncbi Cerebrovascular disorders
    James S Hutchison
    Department of Critical Care and Pediatrics, Hospital for Sick Children, and Interdepartmental Division of Critical Care, Faculty of Medicine, University of Toronto, Toronto, Canada
    Semin Pediatr Neurol 11:139-46. 2004
    ..Children with acute stroke should be rapidly transported to and cared for in a pediatric center with a specialized stroke team or access to acute stroke protocols...
  75. ncbi Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease
    Gjumrakch Aliev
    The Microscopy Research Center and Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA
    Neurotox Res 5:491-504. 2003
    ....
  76. ncbi Prognostic value of a new electrocardiographic method for diagnosis of left ventricular hypertrophy in essential hypertension
    P Verdecchia
    Area Omogenea di Cardiologia e Medicina, Ospedale R Silvestrini, Perugia, Italy
    J Am Coll Cardiol 31:383-90. 1998
    ....
  77. ncbi Cognitive decline following stroke: a comprehensive study of cognitive decline following stroke
    J Hochstenbach
    Sint Maartenskliniek Research, Neurological Institute, University of Nijmegen, The Netherlands
    J Clin Exp Neuropsychol 20:503-17. 1998
    ....
  78. ncbi APOE, vascular pathology, and the AD brain
    A G Yip
    Department of Medicine, Boston University School of Medicine, Bedford, MA, USA
    Neurology 65:259-65. 2005
    ..To use neuropathologic data to examine the association between APOE genotype and cerebrovascular lesions commonly found in Alzheimer disease (AD), as well as neuritic senile plaque (SP) and neurofibrillary tangle (NFT) burden...
  79. ncbi The effects of age on rate of progression of Alzheimer disease and dementia with associated cerebrovascular disease
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Arch Neurol 58:1243-7. 2001
    ..Previous studies have found no differences in progression of Alzheimer disease and vascular dementia, but these studies have not specifically examined age effects...
  80. ncbi Incidence of dementia and associated risk factors in Japan: The Osaki-Tajiri Project
    Kenichi Meguro
    Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Japan
    J Neurol Sci 260:175-82. 2007
    ..A comprehensive system including CDR, cognitive tests, and MRI, is recommended in community-based health policy planning...
  81. doi Diabetes increases atrophy and vascular lesions on brain MRI in patients with symptomatic arterial disease
    Audrey M Tiehuis
    Stroke 39:1600-3. 2008
    ..Macrovascular disease has been described as a determinant for brain MRI changes in DM2, but little is known about the involvement of other DM2-related factors...
  82. pmc AD brain pathology: vascular origins? Results from the HAAS autopsy study
    Lenore J Launer
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C 309 Bethesda, MD 20892, USA
    Neurobiol Aging 29:1587-90. 2008
    ..Our study suggests the burden of vascular and AD type lesions are independent of each other, and are consistent with an additive effect of the two types of lesions on cognitive impairment...
  83. ncbi Comparison between Alzheimer's disease and vascular dementia: implications for treatment
    Raj N Kalaria
    Wolfson Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurol Res 25:661-4. 2003
    ..Cerebrovascular pathology, ischemic brain damage and autonomic dysregulation resulting in cerebral hypoperfusion appears fundamental in the pathogenesis of late-onset dementias...
  84. ncbi Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    Rita Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Diabetes 51:1256-62. 2002
    ..6, 1.5-29.6). Type 2 diabetes is a risk factor for AD and VsD. The association between diabetes and AD is particularly strong among carriers of the APOE epsilon4 allele. The neuropathological data are consistent with the clinical results...
  85. ncbi Low ankle-brachial index predicts an adverse 1-year outcome after acute coronary and cerebrovascular events
    G Agnelli
    Medicina Interna e Cardiovascolare and Stroke Unit, Dipartimento di Medicina Interna, Universita di Perugia, Perugia, Italy
    J Thromb Haemost 4:2599-606. 2006
    ..The aim of this study was to correlate ABI value (normal or low) with 1-year clinical outcome in patients hospitalized for acute coronary syndromes or cerebrovascular diseases (CVD)...
  86. ncbi Evolution of cerebral arteriopathies in childhood arterial ischemic stroke
    Nasuda Danchaivijitr
    Department of Radiology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Ann Neurol 59:620-6. 2006
    ..To investigate evolution of cerebral arteriopathy in children with arterial ischemic stroke (AIS) and its influence on recurrence...
  87. ncbi Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease
    Eva Hogervorst
    Oxford Project to Investigate Memory and Ageing, Department of Pharmacology, University of Oxford and Radcliffe Infirmary Trust, Oxford OX2 6HE, England
    Arch Neurol 59:787-93. 2002
    ..The pathogenesis of leukoaraiosis on computed tomographic (CT) scanning is unknown, but cerebrovascular risk factors for leukoaraiosis show overlap with those for Alzheimer disease (AD)...
  88. doi Improved detection of incipient vascular changes by a biotechnological platform combining post mortem MRI in situ with neuropathology
    Lea Tenenholz Grinberg
    Aging Brain Project, Department of Pathology, University of Sao Paulo Medical School, Av Dr Arnaldo 455, sala 1353 01246903, Sao Paulo, SP, Brazil
    J Neurol Sci 283:2-8. 2009
    ..This protocol will greatly facilitate a systematic study of the location, pathogenesis, clinical impact, prognosis and prevention of WMHs...
  89. ncbi Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease
    Christophe Tzourio
    PROGRESS Collaborative Group c o Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, NSW 2042, Australia
    Arch Intern Med 163:1069-75. 2003
    ..This study aimed to determine whether blood pressure lowering would reduce the risks of dementia and cognitive decline among individuals with cerebrovascular disease...
  90. ncbi Pathophysiology of the vascular wall and its relevance for cerebrovascular disorders in aged rodents
    A Popa-Wagner
    Aging and Neural Repair Laboratory, Clinic of Neurology, Ernst Moritz Arndt University Greifswald, Ellernholz strasse 1 2, Greifswald, Germany
    Curr Neurovasc Res 7:251-67. 2010
    ..Understanding the basic mechanisms underlying functional recovery after cerebral stroke in aging subjects is likely to yield new insights into the treatment of brain injury in the clinic...
  91. ncbi Relationship of vascular risk to the progression of Alzheimer disease
    B Borroni
    Neurology 68:1083-4; author reply 1084. 2007
  92. ncbi White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion
    Masunari Shibata
    Department of Neurology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507 Japan
    Stroke 35:2598-603. 2004
    ..We have successfully established a mouse model of chronic cerebral hypoperfusion that may provide new strategies for the molecular analysis of cerebrovascular WM lesions...
  93. pmc Factors affecting the designation of cerebrovascular diseases as work-related in administrative litigation
    Hyeongsu Kim
    Department of Preventive Medicine, School of Medicine, Konkuk University, Seoul, Korea
    J Korean Med Sci 23:236-42. 2008
    ....
  94. ncbi Vascular pathologies and cognition in a population-based cohort of elderly people
    Malee S Fernando
    Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield, E Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    J Neurol Sci 226:13-7. 2004
    ..Using an MRI strategy to image formalin-fixed brain slices, the study shows that white matter lesions (WMLs) are common (94% overall frequency) and are an independent risk factor for dementia using multivariable analysis...
  95. ncbi Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis
    Jan C M Zijlmans
    Queen Square Brain Bank for Neurological Disorders, Institute of Neurology Queen Square, London, United Kingdom
    Mov Disord 19:630-40. 2004
    ..New clinical criteria for a diagnosis of VP are proposed based on the clinicopathological findings of this study...
  96. doi Crossed cheiro-oral syndrome
    Wei Hsi Chen
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Center, and School of Medicine, Chang Gung University, 123 Tai pei Road, Niao Sung Hsiang, Kaohsiung County 833, Taiwan
    Clin Neurol Neurosurg 110:1008-11. 2008
    ..It results from an involvement of the ascending sensory tracts above the pons. However, a crossed pattern of perioral and acral paresthesia was rarely reported before...
  97. ncbi Outdoor air pollution and stroke in Sheffield, United Kingdom: a small-area level geographical study
    Ravi Maheswaran
    Public Health GIS Unit, School of Health and Related Research, The University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, United Kingdom
    Stroke 36:239-43. 2005
    ..We examined this hypothesis using a small-area level ecological correlation study...
  98. ncbi Emerging therapies for cerebrovascular disorders
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Worcester 01605, USA
    Stroke 35:367-9. 2004
  99. ncbi Cigarette smoking as a determinant of high-grade carotid artery stenosis in Hispanic, black, and white patients with stroke or transient ischemic attack
    H Mast
    Stroke Unit, The Neurological Institute, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Stroke 29:908-12. 1998
    ..We sought to investigate the association of cigarette smoking with high-grade carotid artery stenosis in Hispanic, black, and white patients with cerebral ischemia in two independent samples...
  100. ncbi Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res 999:53-61. 2004
    ..All together, these data suggest that nilvadipine might be useful for the treatment of oligemia associated with AD...
  101. ncbi Associations between white matter lesions, cerebrovascular risk factors, and low CSF Abeta42
    V Stenset
    Department of Neurology, Akershus University Hospital, Sykehusveien 27, NO 1478 Lørenskog, Norway
    Neurology 67:830-3. 2006
    ..To analyze a putative relationship between white matter lesions (WMLs), risk factors for WMLs, and Alzheimer disease (AD) as measured with the surrogate marker CSF Abeta42...

Research Grants103 found, 100 shown here

  1. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    MICHAL J TOBOREK; Fiscal Year: 2010
    ..evidence that even moderate exercise can significantly contribute to brain regeneration in chronic cerebrovascular disorders. PUBLIC HEALTH RELEVANCE: Methamphetamine (METH) abuse results in a long-term impairment of vascular ..
  2. Effects of VEGF on Brain Tissue in vitro
    JEFFREY ROSENSTEIN; Fiscal Year: 2004
    ..As an angiogenic factor VEGF could have potential use in cerebrovascular disorders but may also have trophic effects upon astroglia and neurons...
  3. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2006
    ..While there is evidence, which suggests that smoking is a risk factor for the pathogenesis of cerebrovascular disorders, including stroke, mechanisms, which contribute to the development of cerebrovascular disorders remain ..
  4. Neurological Emergencies Treatment Trials (NETT)
    David Wright; Fiscal Year: 2007
    ..will 1) facilitate high-quality clinical trials in a wide variety of neurological diseases (cerebrovascular disorders, epileptic seizures, acute infections of the CNS, acute neuromuscular disorders and trauma) in adults or ..
  5. Metabolic Effects of Newer Antipsychotics in Older Pts
    Dilip Jeste; Fiscal Year: 2007
    ..experienced multidisciplinary team of investigators (including experts in metabolic, cardiovascular, and cerebrovascular disorders), and infrastructure support provided by an NIMH-funded Advanced Center for Interventions and Services ..
  6. Metabolic Effects of Newer Antipsychotics in Older Pts
    Dilip Jeste; Fiscal Year: 2009
    ..experienced multidisciplinary team of investigators (including experts in metabolic, cardiovascular, and cerebrovascular disorders), and infrastructure support provided by an NIMH-funded Advanced Center for Interventions and Services ..
  7. A New Collagen Expressed Primarily in Brain Tissue
    JEANNE MYERS; Fiscal Year: 2002
    ..Furthermore, neurodegenerative diseases such as Alzheimer's, Parkinson's, cerebrovascular disorders, together with epilepsy and multiple sclerosis, constitute a major class of devastating conditions which ..
  8. Vascular Smooth Muscle Notch Signaling in Arterial Patterning and Function
    Aaron Proweller; Fiscal Year: 2010
    ..The results from these investigations will provide the foundation for novel therapies for the treatment of vascular insufficiencies such as peripheral and cerebral arterial disease. ..
  9. Transgenic Murine Model of Brain Vascular Malformation
    Guo Yuan Yang; Fiscal Year: 2004
    ..This non-tumor angiogenesis rodent preparation will serve as a model of disordered human cerebral angiogenesis, leading relatively quickly to the ability to test new therapeutic approaches for cerebrovascular disorders.
  10. MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCH
    Larry Goldstein; Fiscal Year: 2004
    ....
  11. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  12. MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORS
    Raj Kalaria; Fiscal Year: 2007
    ....
  13. Midcareer Investigator Award in Geriatric Depression
    David Steffens; Fiscal Year: 2007
    ..Under the Award, the candidate will spend at least 50 percent of his time conducting patient-oriented research and mentoring. ..
  14. Geriatric Depression: Risk Factors for Adverse Outcomes
    David C Steffens; Fiscal Year: 2011
    ..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..
  15. Geriatric Depression: Risk Factors for Adverse Outcomes
    David C Steffens; Fiscal Year: 2010
    ..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..
  16. PREMIER Mental Health Interventions Training Program
    David Steffens; Fiscal Year: 2007
    ..By the end of two years of training, each fellow will have extensive experience and training in clinical trials that will enable them to obtain appointments as junior faculty. ..
  17. Frontotemporal degeneration: a basis for clinical trials
    David Knopman; Fiscal Year: 2006
    ..abstract_text> ..
  18. GERIATRIC DEPRESSION--RISK FACTORS FOR ADVERSE OUTCOME
    David Steffens; Fiscal Year: 2000
    ..Results in this clinical population will be valuable for comparison with epidemiological data. This project benefits from the resources of the Duke Mental Health Clinical Research Center for essential support. ..
  19. Geriatric Depression: Risk Factors for Adverse Outcomes
    David Steffens; Fiscal Year: 2006
    ..abstract_text> ..
  20. Quantifying Collateral Perfusion in Cerebrovascular Disease
    GREGORY ZAHARCHUK; Fiscal Year: 2009
    ....
  21. 1H MRS markers of MCI syndromes and common dementias
    Kejal Kantarci; Fiscal Year: 2007
    ....
  22. Regulation and Function of Tissue Kallikrein
    Julie Chao; Fiscal Year: 2010
    ..This study should generate important information to provide the impetus for developing therapeutic regimens in the prevention of cardiac dysfunction and heart failure. ..
  23. COX2 GENE EXPRESSION AND ISCHEMIC BRAIN DAMAGE
    Costantino Iadecola; Fiscal Year: 2000
    ..Preliminary results suggest that this is a most promising area of research that will advance our understanding of the fundamental mechanisms of cerebral ischemia and may unveil new avenues for stroke treatment. ..
  24. Cognitive reserve and age-related brain changes
    Adam Brickman; Fiscal Year: 2005
    ..Results from the study will provide important insights into the normal aging process and will yield valuable information towards understanding the underpinnings of age-associated pathologies. ..
  25. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2007
    ..K24 support will provide the applicant with protected time to continue to carry out depression studies in late life depression and to increase the mentoring of beginning clinical investigators in neuroimaging studies in depression. ..
  26. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2007
    ..Identification of causal factors and molecular mechanisms responsible for disruption of vascular integrity in diabetes will advance stroke treatment by reducing the risk of hemorrhage and improve stroke outcome. ..
  27. fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION
    Yvette Sheline; Fiscal Year: 2009
    ..Brain activity will be compared before and after treatment for these tasks in both CBT and antidepressant medication. This will add to our understanding of treatment mechanisms for major depression. ..
  28. Vascular factors, amyloid beta, and Alzheimer's disease
    Jose Luchsinger; Fiscal Year: 2004
    ..abstract_text> ..
  29. Mitochondriopathy of Chronically Ischemic Muscle
    Iraklis Pipinos; Fiscal Year: 2007
    ..Aim 3: Correlate mitochondrial dysfunction with muscle contractile properties. Aim 4: Correlate mitochondrial dysfunction with oxidative damage in the ischemic skeletal muscle. ..