cerebrovascular disorders

Summary

Summary: A broad category of disorders characterized by impairment of blood flow in the arteries and veins which supply the brain. These include CEREBRAL INFARCTION; BRAIN ISCHEMIA; HYPOXIA, BRAIN; INTRACRANIAL EMBOLISM AND THROMBOSIS; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; and VASCULITIS, CENTRAL NERVOUS SYSTEM. In common usage, the term cerebrovascular disorders is not limited to conditions that affect the cerebrum, but refers to vascular disorders of the entire brain including the DIENCEPHALON; BRAIN STEM; and CEREBELLUM.

Top Publications

  1. ncbi High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities
    Paola Michelozzi
    Department of Epidemiology Local Health Authority Rome E, Rome, Italy
    Am J Respir Crit Care Med 179:383-9. 2009
  2. pmc Vascular pathology in the aged human brain
    Lea Tenenholz Grinberg
    Department of Neurology, University of California San Francisco, 305 Parnassus Avenue, San Francisco, CA 94143, USA
    Acta Neuropathol 119:277-90. 2010
  3. pmc Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders
    Isidro Salcedo
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Br J Pharmacol 166:1586-99. 2012
  4. pmc Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    Robert D Bell
    Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Acta Neuropathol 118:103-13. 2009
  5. ncbi White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion
    Masunari Shibata
    Department of Neurology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507 Japan
    Stroke 35:2598-603. 2004
  6. pmc All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort study
    Rosa Liperoti
    Centro di Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8 0168 Rome, Italy
    J Clin Psychiatry 70:1340-7. 2009
  7. ncbi Circulating vitamin D, calcium and risk of cerebrovascular disease: a systematic review and meta-analysis
    Rajiv Chowdhury
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Epidemiol 27:581-91. 2012
  8. ncbi Cerebrovascular disorders: molecular insights and therapeutic opportunities
    Erik Storkebaum
    Molecular Neurogenetics Laboratory, Max Planck Institute for Molecular Biomedicine, Muenster, Germany
    Nat Neurosci 14:1390-7. 2011
  9. ncbi Reversible cerebral vasoconstriction syndromes: analysis of 139 cases
    Aneesh B Singhal
    Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA
    Arch Neurol 68:1005-12. 2011
  10. ncbi Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease
    Hector H Palacios
    Department of Biology, College of Sciences, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 1664, USA
    CNS Neurol Disord Drug Targets 10:149-62. 2011

Detail Information

Publications253 found, 100 shown here

  1. ncbi High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities
    Paola Michelozzi
    Department of Epidemiology Local Health Authority Rome E, Rome, Italy
    Am J Respir Crit Care Med 179:383-9. 2009
    ..Episode analyses of heat waves have documented a comparatively higher impact on mortality than on morbidity (hospital admissions) in European cities. The evidence from daily time series studies is scarce and inconsistent...
  2. pmc Vascular pathology in the aged human brain
    Lea Tenenholz Grinberg
    Department of Neurology, University of California San Francisco, 305 Parnassus Avenue, San Francisco, CA 94143, USA
    Acta Neuropathol 119:277-90. 2010
    ....
  3. pmc Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders
    Isidro Salcedo
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Br J Pharmacol 166:1586-99. 2012
    ..Herein, we review the physiological role of GLP-1 in the nervous system, focused towards the potential benefit of GLP-1R stimulation as an immediately translatable treatment strategy for acute and chronic neurological disorders...
  4. pmc Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    Robert D Bell
    Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Acta Neuropathol 118:103-13. 2009
    ..The data reviewed here support an essential role of neurovascular and BBB mechanisms in contributing to both, onset and progression of AD...
  5. ncbi White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion
    Masunari Shibata
    Department of Neurology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507 Japan
    Stroke 35:2598-603. 2004
    ..We have successfully established a mouse model of chronic cerebral hypoperfusion that may provide new strategies for the molecular analysis of cerebrovascular WM lesions...
  6. pmc All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort study
    Rosa Liperoti
    Centro di Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8 0168 Rome, Italy
    J Clin Psychiatry 70:1340-7. 2009
    ..We conducted a retrospective cohort study to compare the risk of death associated with atypical and conventional antipsychotics in a large population of nursing home residents with dementia...
  7. ncbi Circulating vitamin D, calcium and risk of cerebrovascular disease: a systematic review and meta-analysis
    Rajiv Chowdhury
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Epidemiol 27:581-91. 2012
    ..Conversely, higher circulating calcium concentration is associated with an increased risk of cerebrovascular disease...
  8. ncbi Cerebrovascular disorders: molecular insights and therapeutic opportunities
    Erik Storkebaum
    Molecular Neurogenetics Laboratory, Max Planck Institute for Molecular Biomedicine, Muenster, Germany
    Nat Neurosci 14:1390-7. 2011
    ..These genetic insights offer alternative therapeutic options, some of which are being evaluated in the clinic...
  9. ncbi Reversible cerebral vasoconstriction syndromes: analysis of 139 cases
    Aneesh B Singhal
    Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA
    Arch Neurol 68:1005-12. 2011
    ..To compare the clinical, laboratory, and imaging features of patients with reversible cerebral vasoconstriction syndromes evaluated at 2 academic centers, compare subgroups, and investigate treatment effects...
  10. ncbi Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease
    Hector H Palacios
    Department of Biology, College of Sciences, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 1664, USA
    CNS Neurol Disord Drug Targets 10:149-62. 2011
    ....
  11. ncbi The Essen stroke risk score predicts recurrent cardiovascular events: a validation within the REduction of Atherothrombosis for Continued Health (REACH) registry
    Christian Weimar
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Stroke 40:350-4. 2009
    ..We aimed to validate the ESRS in a large cohort of outpatients with previous transient ischemic attack or stroke from the REduction of Atherothrombosis for Continued Health (REACH) Registry...
  12. ncbi Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography
    R J Adams
    Department of Neurology, Medical College of Georgia, Augusta 30912 3200, USA
    N Engl J Med 339:5-11. 1998
    ..We used transcranial Doppler ultrasonography to identify children with sickle cell anemia who were at high risk for stroke and then randomly assigned them to receive standard care or transfusions to prevent a first stroke...
  13. ncbi A clinical comparison of definite moyamoya disease between South Korea and Japan
    K Ikezaki
    Department of Neurosurgery, Kyushu University Faculty of Medicine, Fukuoka, Japan
    Stroke 28:2513-7. 1997
    ..The goal of the present study was to clarify whether South Korean patients with moyamoya disease have clinical features similar to those of Japanese patients...
  14. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  15. ncbi Transcranial color doppler study for reversible cerebral vasoconstriction syndromes
    Shih Pin Chen
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Ann Neurol 63:751-7. 2008
    ..Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by thunderclap headaches and reversible cerebral vasoconstrictions. No systematic studies on cerebral hemodynamics have been published...
  16. ncbi Prior polyvascular disease: risk factor for adverse ischaemic outcomes in acute coronary syndromes
    Deepak L Bhatt
    VA Boston Healthcare System and Brigham and Women s Hospital, Boston, MA, USA
    Eur Heart J 30:1195-202. 2009
    ....
  17. ncbi Treatment of vascular risk factors is associated with slower decline in Alzheimer disease
    Yan Deschaintre
    Universite Lille Nord de France, INSERM UMR 744, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
    Neurology 73:674-80. 2009
    ..The aim of this observational study was to evaluate whether the treatment of VRF is associated with a slower cognitive decline in patients who have AD without cerebrovascular disease (CVD)...
  18. ncbi Brain hypoperfusion: a critical factor in vascular dementia
    Gustavo C Roman
    University of Texas Health Science Center at San Antonio and the Audie L Murphy Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, San Antonio, USA
    Neurol Res 26:454-8. 2004
    ..Recognition of the susceptibility of elderly subjects to cerebral lesions induced by hypoperfusion should result in appropriate preventive measures and better treatment...
  19. ncbi Incidence and short-term prognosis of transient ischemic attack in a population-based study
    Dawn Kleindorfer
    Department of Emergency Medicine, University of Cincinnati, Ohio, USA
    Stroke 36:720-3. 2005
    ..We present the incidence and short-term prognosis of TIA within a large population with a significant proportion of minorities with out-of-hospital TIA...
  20. ncbi MRI white matter hyperintensities: three-year follow-up of the Austrian Stroke Prevention Study
    R Schmidt
    Department of Neurology, Institute of Medical Biochemistry, Karl Franzens University, Graz, Austria
    Neurology 53:132-9. 1999
    ..To determine the rate, clinical predictors, and cognitive consequences of MRI white matter hyperintensity evolution over 3 years...
  21. pmc Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Neurology 59:867-73. 2002
    ..To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI)...
  22. ncbi Increased arterial stiffness is independently related to cerebrovascular disease and aneurysms of the abdominal aorta: the Second Manifestations of Arterial Disease (SMART) Study
    J M Dijk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnummer Str 6 131, PO Box 85060, 3508 BA Utrecht, The Netherlands
    Stroke 35:1642-6. 2004
    ..Arterial stiffness is a risk factor for stroke and myocardial infarction. We investigated whether carotid arterial stiffness is related to other localizations of manifest arterial disease...
  23. ncbi Neuroimaging in cerebrovascular disorders: measurement of cerebral physiology after stroke and assessment of stroke recovery
    James M Mountz
    Department of Radiology, Division of Nuclear Medicine, University of Alabama at Birmingham Medical Center, Birmingham, AL 35249 6835, USA
    Semin Nucl Med 33:56-76. 2003
    ..The value of these results on rehabilitation strategy, including possible criteria for the use of facilitatory versus compensatory approaches, is analyzed...
  24. ncbi Community-based study of stroke incidence in the Valley of Aosta, Italy. CARe-cerebrovascular Aosta Registry: years 2004-2005
    Giovanni Corso
    Stroke Unit, Department of Neurology, Ospedale Regionale, Aosta, Italy
    Neuroepidemiology 32:186-95. 2009
    ....
  25. pmc Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS
    K Kantarci
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Neurology 72:1519-25. 2009
    ..To investigate the combined ability of hippocampal volumes, 1H magnetic resonance spectroscopy (MRS) metabolites, and cerebrovascular disease to predict the risk of progression to dementia in mild cognitive impairment (MCI)...
  26. ncbi A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Vasc Surg 50:1348-58.e1-3. 2009
    ..CCSVI is strongly associated with multiple sclerosis (MS). This study evaluated the safety of CCSVI endovascular treatment and its influence on the clinical outcome of the associated MS...
  27. ncbi Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychotics
    Sanford Finkel
    Medical Affairs at Council for Jewish Elderly, and the University of Chicago Medical School, IL, USA
    Int Psychogeriatr 17:617-29. 2005
    ..The objective was to determine whether risperidone is associated with an increased risk of CVEs relative to other commonly considered alternative treatments...
  28. ncbi Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    Rita Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Diabetes 51:1256-62. 2002
    ..6, 1.5-29.6). Type 2 diabetes is a risk factor for AD and VsD. The association between diabetes and AD is particularly strong among carriers of the APOE epsilon4 allele. The neuropathological data are consistent with the clinical results...
  29. ncbi Trends, predictors, and outcomes of cerebrovascular events related to percutaneous coronary intervention: a 16-year single-center experience
    Scott J Hoffman
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    JACC Cardiovasc Interv 4:415-22. 2011
    ..We sought to determine trends, predictors, in-hospital and long-term outcomes of cerebrovascular events (CVE) related to percutaneous coronary intervention (PCI) over a 16-year period...
  30. ncbi Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndrome
    W S Bartynski
    Department of Radiology, Division of Neuroradiology, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    AJNR Am J Neuroradiol 28:1320-7. 2007
    ..We evaluated lesion distribution with CT and MR in a large cohort of patients who experienced PRES to comprehensively assess the imaging patterns identified...
  31. ncbi Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    Eric E Smith
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arch Neurol 65:94-100. 2008
    ..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...
  32. ncbi Patient skin dose during neuroembolization by multiple-point measurement using a radiosensitive indicator
    S Suzuki
    Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan
    AJNR Am J Neuroradiol 29:1076-81. 2008
    ..The purpose of this research was to evaluate the patient's entrance skin dose (ESD) during neuroembolizations in 6 institutions...
  33. ncbi Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review
    Atticus H Hainsworth
    Centre for Clinical Neuroscience, Division of Cardiac and Vascular Sciences, St George s University of London, London, UK
    J Cereb Blood Flow Metab 28:1877-91. 2008
    ..The most-used model was the stroke-prone spontaneously hypertensive rat (SHR-SP). No model described all features of the human disease. The optimal choice of model depends on the aspect of pathophysiology being studied...
  34. ncbi Hypertension and cerebral diffusion tensor imaging in small vessel disease
    Rob A R Gons
    Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Stroke 41:2801-6. 2010
    ..Diffusion tensor imaging provides measures of structural integrity...
  35. ncbi Fish consumption and the incidence of cerebrovascular disease
    Jukka Montonen
    Department of Health and Functional Capacity, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Br J Nutr 102:750-6. 2009
    ..The relationship between fish consumption and stroke risk is not straightforward. How the fish is prepared for consumption may play an important role, affecting the association...
  36. ncbi Alzheimer’s disease, cerebrovascular disease, and the β-amyloid cascade
    Kie Honjo
    L C Campbell Cognitive Neurology Research Unit Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada
    Can J Neurol Sci 39:712-28. 2012
    ..In this review, we review the role of vascular factors and Aβ, underlining that vascular risk factor management may be important for AD prevention and treatment...
  37. ncbi 4-D Imaging in cerebrovascular disorders by using 320-slice CT: feasibility and preliminary clinical experience
    Randolf Klingebiel
    Department of Neuroradiology, Charite, University Medicine Berlin, Berlin, Germany
    Acad Radiol 16:123-9. 2009
    The authors report study protocols and initial clinical experience in assessing patients with acute and chronic cerebrovascular disorders using the recently introduced technique of volume computed tomography (VCT).
  38. ncbi 5-year outcomes following percutaneous coronary intervention with drug-eluting stent implantation versus coronary artery bypass graft for unprotected left main coronary artery lesions the Milan experience
    Alaide Chieffo
    Interventional Cardiology Unit, Department of Cardio Thoracic and Vascular Diseases, San Raffaele Scientific Institute, Milan, Italy
    JACC Cardiovasc Interv 3:595-601. 2010
    ....
  39. ncbi Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk
    R Takechi
    School of Public Health, Curtin Health Innovation Research Institute, Australian Technology Network Centre for Metabolic Fitness, Curtin University of Technology, Bentley Campus, Kent Street, Perth 6102, Australia
    Prog Lipid Res 49:159-70. 2010
    ..Clearly, delineating the mechanisms by which dietary fats increase AD risk may be informative in developing new strategies for prevention and treatment of AD...
  40. ncbi Cerebrovascular disorders in children
    John Kylan Lynch
    Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, NIH DHHS, Building 10, Room 5S220, 10 Center Drive, MSC 1447, Bethesda, MD 20892 1447, USA
    Curr Neurol Neurosci Rep 4:129-38. 2004
    b>Cerebrovascular disorders are an important cause of mortality and chronic morbidity in children. International incidence rates for childhood stroke (ie, from 30 days to 18 years of age) have ranged from 1.3 to 13 per 100,000 children...
  41. ncbi Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice
    Hiroshi Kitaguchi
    Department of Neurology, Kyoto University, Sakyo ku, Kyoto 606 8504, Japan
    Brain Res 1294:202-10. 2009
    ..Taken together, chronic cerebral hypoperfusion increased Abeta fibrils and induced Abeta deposition in the intracellular compartment and, therefore, may accelerate the pathological changes of Alzheimer's disease...
  42. ncbi Genetics of cerebrovascular disorders
    James F Meschia
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
    Mayo Clin Proc 80:122-32. 2005
    ..This article reviews the clinical and genetic features of some mendellan and mitochondrial disorders associated with ischemic stroke, hemorrhagic stroke, and cerebrovascular malformations...
  43. ncbi Dilatation of the Virchow-Robin space is a sensitive indicator of cerebral microvascular disease: study in elderly patients with dementia
    Tufail F Patankar
    Institutions Imaging Science and Biomedical Engineering, School of Medicine, University of Manchester, UK
    AJNR Am J Neuroradiol 26:1512-20. 2005
    ..The aim of our study was to test the hypothesis that dilatation of VRS is associated with subcortical vascular dementia...
  44. ncbi Urban air pollution and emergency admissions for cerebrovascular diseases in Taipei, Taiwan
    Chang Chuan Chan
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Rm 722, 7F, No 17, Xu Zhou Road, Taipei 100, Taiwan, ROC
    Eur Heart J 27:1238-44. 2006
    ..This study was designed to evaluate the association between urban air pollutants and emergency admissions for cerebrovascular diseases...
  45. pmc Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators
    Narayan R Bhat
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 115:551-62. 2010
    ....
  46. ncbi Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease
    Gjumrakch Aliev
    The Microscopy Research Center and Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA
    Neurotox Res 5:491-504. 2003
    ....
  47. ncbi Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders
    Ryuichi Ohkubo
    Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Neurol Sci 198:31-5. 2002
    ..Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD...
  48. ncbi Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist
    Nektaria Nicolakakis
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurosci 28:9287-96. 2008
    ....
  49. ncbi Cardiovascular epidemiology in the Asia-Pacific region
    G L Khor
    Department of Nutrition and Health Sciences, Faculty, of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang
    Asia Pac J Clin Nutr 10:76-80. 2001
    ..Thus, monitoring the impact of these changes on cardiovascular risks is essential to enable the implementation of appropriate strategies towards countering the rise of CVD mortality...
  50. ncbi Females with Fabry disease frequently have major organ involvement: lessons from the Fabry Registry
    William R Wilcox
    Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd SSB, Los Angeles, CA 90048, USA
    Mol Genet Metab 93:112-28. 2008
    ..Thus, females with FD have a significant risk for major organ involvement and decreased QoL. Females should be regularly monitored for signs and symptoms of FD, and considered for enzyme replacement therapy...
  51. ncbi White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Austria
    Ann Neurol 58:610-6. 2005
    ....
  52. ncbi Vascular basis of Alzheimer's pathogenesis
    J C de La Torre
    Division of Neuropathology, University of California San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    Ann N Y Acad Sci 977:196-215. 2002
    ....
  53. ncbi Vitamin D status and the risk of cardiovascular disease death
    Annamari Kilkkinen
    National Institute for Health and Welfare, Helsinki, Finland
    Am J Epidemiol 170:1032-9. 2009
    ..These findings need to be replicated in other populations. To demonstrate a causal link between vitamin D and CVD, randomized controlled trials are required...
  54. pmc Work-related cerebro-cardiovascular diseases in Korea
    Dae Seong Kim
    Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Korea
    J Korean Med Sci 25:S105-11. 2010
    ..The strategic approach is needed essentially because CVDs are common, serious and preventable diseases which lead to economic burden...
  55. ncbi Hypertension and cerebrovascular damage
    Franco Veglio
    University of Turin, Italy
    Atherosclerosis 205:331-41. 2009
    ..Cerebral parenchymal and functional damages have to be considered together to make medical intervention more incisive...
  56. ncbi Alzheimer disease as a vascular disorder: nosological evidence
    J C de La Torre
    Department of Neuropathology, University of California at San Diego, CA 92026, USA
    Stroke 33:1152-62. 2002
    ..The main stumbling block in the clinical management and in the search for a cure of Alzheimer disease (AD) is that the cause of this disorder has remained uncertain until now...
  57. ncbi Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
    A Joutel
    INSERM U25, Faculte de Medecine Necker Enfants Malades, Paris, France
    Nature 383:707-10. 1996
    ..We have identified mutations in CADASIL patients that cause serious disruption of this gene, indicating that Notch3 could be the defective protein in CADASIL patients...
  58. ncbi The burden of paediatric stroke and cerebrovascular disorders in Croatia
    J Lenicek Krleza
    Department of Laboratory Diagnostics, University School of Medicine and Children s Hospital Zagreb, Klaiceva 16, Zagreb 10000, Croatia
    Int J Stroke 4:390-4. 2009
    ..Obtained data will contribute to better understanding of paediatric stroke in Croatia and will provide a base for the establishment of the national referral center and national pediatric stroke registry...
  59. ncbi Cerebral atrophy in cerebrovascular disorders
    Eric Jouvent
    Department of Neurology, Hopital Lariboisiere, Assistance Pulique Hôpitaux de Paris and Université Paris VII, Paris, France
    J Neuroimaging 20:213-8. 2010
    ..Recent data suggest that brain atrophy is prominent in various cerebrovascular disorders. Studies of the effects of different cerebrovascular magnetic resonance imaging (MRI) markers and of the ..
  60. ncbi Repetitive use of intra-arterial verapamil in the treatment of reversible cerebral vasoconstriction syndrome
    Kris F French
    Department of Neurology and Clinical Neurosciences, Clinical Neurosciences Center, University of Utah Hospitals and Clinics, 175 N Medical Drive East, Salt Lake City 84132, UT, USA
    J Clin Neurosci 19:174-6. 2012
    ....
  61. pmc Arterial spin-labeled MR perfusion imaging: clinical applications
    Jeffrey M Pollock
    Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Magn Reson Imaging Clin N Am 17:315-38. 2009
    ..The appearance of pathology is affected significantly by the ASL techniques used. Familiarity with the available sequence parameter options and the common appearances of pathology facilitates perfusion interpretation...
  62. ncbi Is Chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction?
    Seyed Mohammad Alavi
    Infectious disease ward, Razi Hospital, Ahvaz Joundishapour University of Medical Sciences, Ahvaz, Iran
    J Infect Public Health 2:96-9. 2009
    ..Since these studies have reported controversial results, we performed this study to identify whether Cp-immunoglobulin was associated with atherothrombotic cerebrovascular infarction (ACI) in Iranian patients...
  63. ncbi Carotid plaque morphology and cerebrovascular events
    G Carra
    Department of Vascular Medicine, Internal Medicine and General Medicine, University of Padua, Civil Hospital, Castelfranco Veneto TV, Italy
    Int Angiol 22:284-9. 2003
    ..Our aim was to evaluate the relationship between plaque morphology, progression of stenosis, and the development of new cerebrovascular events...
  64. ncbi Cerebrovascular disease and dementia
    Chiadi U Onyike
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int Rev Psychiatry 18:423-31. 2006
    ..Our knowledge of the risk factors has also provided opportunities for the primary and secondary prevention of vascular dementia, and indicates promising avenues for research...
  65. ncbi The North American Symptomatic Carotid Endarterectomy Trial : surgical results in 1415 patients
    G G Ferguson
    John P Robarts Research Institute, London, Ontario, Canada gary
    Stroke 30:1751-8. 1999
    ..This study reports the surgical results in those patients who underwent carotid endarterectomy in the North American Symptomatic Carotid Endarterectomy Trial (NASCET)...
  66. ncbi Long-term safety and cognitive effects of galantamine in the treatment of probable vascular dementia or Alzheimer's disease with cerebrovascular disease
    A F Kurz
    Department of Psychiatry and Psychotherapy, Technische Universitaet Munchen, Munich, Germany
    Eur J Neurol 10:633-40. 2003
    ..Long-term (up to 24 months) galantamine therapy in patients with VaD and AD with CVD is well tolerated and associated with prolonged maintenance of cognitive function...
  67. pmc Age and apoE associations with complex pathologic features in Alzheimer's disease
    Gregory A Jicha
    Department of Neurology, Mayo Clinic, Rochester, MN, Jacksonville, FL, United States
    J Neurol Sci 273:34-9. 2008
    ....
  68. ncbi Genetic variation in white matter hyperintensity volume in the Framingham Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, B 609, Boston, Mass 02118, USA
    Stroke 35:1609-13. 2004
    ..73). We investigated heritability of WMH in a family-based sample of the Framingham Heart Study for sex differences and the impact of age...
  69. pmc Risk estimations, risk factors, and genetic variants associated with Alzheimer's disease in selected publications from the Framingham Heart Study
    Galit Weinstein
    Department of Neurology, Boston University School of Medicine, Boston, MA 20008, USA
    J Alzheimers Dis 33:S439-45. 2013
    ..The second is a large meta-analysis GWA study of AD, in which novel loci of AD susceptibility were found. Together, these findings demonstrate the FHS multi-directional efforts in investigating dementia and AD...
  70. ncbi Role of methylenetetrahydrofolate reductase gene (MTHFR) 677C>T polymorphism in pediatric cerebrovascular disorders
    Hamza Alsayouf
    Division of Child Neurology, The Ohio State University, Columbus, Nationwide Children s Hospital, OH 43205, USA
    J Child Neurol 26:318-21. 2011
    ..However, the data suggest that the MTHFR TT genotype may influence migraine susceptibility in children because there was a higher proportion of migraine patients (28.6%) with the MTHFR TT homozygous genotype...
  71. ncbi Calcium and magnesium in drinking water and risk of death from cerebrovascular disease
    C Y Yang
    School of Public Health, Kaohsiung Medical College, Taiwan, Republic of China
    Stroke 29:411-4. 1998
    ..This report examines whether calcium and magnesium in drinking water are protective against cerebrovascular disease...
  72. ncbi Prior peripheral arterial disease and cerebrovascular disease are independent predictors of adverse outcome in patients with acute coronary syndromes: are we doing enough? Results from the Orbofiban in Patients with Unstable Coronary Syndromes-Thrombolysi
    Gad Cotter
    Cardiology Institutes of Assaf Harofeh Medical Center, Zerifin, Israel
    Am Heart J 145:622-7. 2003
    ....
  73. ncbi Two-year vascular event rates in patients with symptomatic cerebrovascular disease: the REACH registry
    Narayanaswamy Venketasubramanian
    Division of Neurology, National University Hospital, Singapore
    Cerebrovasc Dis 32:254-60. 2011
    ..We describe 2-year vascular outcomes among symptomatic CeVD patients from the REduction of Atherothrombosis for Continued Health (REACH) Registry...
  74. ncbi Comparison of coronary artery bypass surgery and percutaneous drug-eluting stent implantation for treatment of left main coronary artery stenosis
    Anthony J White
    Cedars Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California 90048, USA
    JACC Cardiovasc Interv 1:236-45. 2008
    ..The purpose of this study was to compare outcomes for drug-eluting stents (DES) and coronary artery bypass graft (CABG) surgery in patients with unprotected left main coronary artery (ULMCA) stenosis...
  75. ncbi Progression of cerebral white matter lesions -- clinical and radiological considerations
    Christian Enzinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    J Neurol Sci 257:5-10. 2007
    ..Power calculations based on quantitative data of the Austrian Stroke Prevention Study (ASPS) suggest that such studies would be feasible...
  76. ncbi Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Neurol Sci 287:45-51. 2009
    ..9 were significant predisposing factors for stroke. Patients with CVD and co-existing atherothrombotic diseases had a high risk of recurrent events, including events arising in other vascular beds than originally diagnosed...
  77. ncbi The blood-brain barrier/neurovascular unit in health and disease
    Brian T Hawkins
    Department of Medical Pharmacology, University of Arizona College of Medicine, Tucson, Arizona, USA
    Pharmacol Rev 57:173-85. 2005
    ..Therefore, understanding how BBB TJ might be affected by various factors holds significant promise for the prevention and treatment of neurological diseases...
  78. ncbi Cerebral hyperperfusion syndrome after percutaneous transluminal stenting of the craniocervical arteries
    P M Meyers
    Department of Radiology, University of California at San Francisco, USA
    Neurosurgery 47:335-43; discussion 343-5. 2000
    ..To our knowledge, there are no previous studies evaluating the incidence of hyperperfusion syndrome after percutaneous transluminal angioplasty/stenting...
  79. ncbi Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease
    Hiroshi Kitaguchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Neurosci Lett 417:128-31. 2007
    ..Cortical microvascular changes in AD and their absence in BD may indicate a role of beta amyloid for the microvessel pathology in AD...
  80. ncbi Quantitative cerebral blood flow determinations in acute ischemic stroke. Relationship to computed tomography and angiography
    A D Firlik
    Department of Neurological Surgery, University of Pittsburgh Medical Center, PA 15213, USA
    Stroke 28:2208-13. 1997
    ....
  81. ncbi Prediction of cerebral hyperperfusion syndrome after carotid stenting: a cerebral perfusion computed tomography study
    Ying Chi Tseng
    Department of Radiology, Cathay General Hospital, Taipei, Taiwan, Republic of China
    J Comput Assist Tomogr 33:540-5. 2009
    ..The objective of this study was to evaluate the role of cerebral perfusion computed tomography (CT) in predicting cerebral hyperperfusion syndrome (CHS) after carotid stenting...
  82. ncbi Size fractionate particulate matter, vehicle traffic, and case-specific daily mortality in Barcelona, Spain
    L Perez
    Center for research in environmental epidemiology CREAL, Dr Aiguader 88, 08003 Barcelona, Spain
    Environ Sci Technol 43:4707-14. 2009
    ..Vehicle traffic PM, generated by combustion and noncombustion processes, should be considered in air pollution mitigation strategies in urban areas...
  83. ncbi Advances in molecular genetics and pathology of cerebrovascular disorders
    R N Kalaria
    Wolfson Research Centre, Institute for Health of the Elderly, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Trends Neurosci 24:392-400. 2001
    ..in molecular genetics has enabled the dissection of several autosomal dominantly inherited forms of cerebrovascular disorders. Mutations in diverse genes might induce pathological changes in intracranial vessels, resulting in ..
  84. ncbi Vascular pathologies and cognition in a population-based cohort of elderly people
    Malee S Fernando
    Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield, E Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    J Neurol Sci 226:13-7. 2004
    ..Using an MRI strategy to image formalin-fixed brain slices, the study shows that white matter lesions (WMLs) are common (94% overall frequency) and are an independent risk factor for dementia using multivariable analysis...
  85. ncbi Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study
    W T Longstreth
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 27:1274-82. 1996
    ..Our aim was to identify potential risk factors for and clinical manifestations of white matter findings on cranial MRI in elderly people...
  86. ncbi Agalsidase-beta therapy for advanced Fabry disease: a randomized trial
    Maryam Banikazemi
    Mount Sinai School of Medicine of New York University, New York, New York, USA
    Ann Intern Med 146:77-86. 2007
    ..Fabry disease (alpha-galactosidase A deficiency) is a rare, X-linked lysosomal storage disorder that can cause early death from renal, cardiac, and cerebrovascular involvement...
  87. ncbi Alzheimer disease and cerebrovascular pathology: an update
    K A Jellinger
    Ludwig Boltzmann Institute of Clinical Neurobiology, Otto Wagner Hospital, Vienna, Austria
    J Neural Transm 109:813-36. 2002
    ..Further studies will help to elucidate the risk factors and impact of cerebrovascular lesions on the development and progression of dementia in AD...
  88. ncbi Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Lancet 359:1283-90. 2002
    ..We investigated the effects of galantamine in patients with a diagnosis of probable vascular dementia or Alzheimer's disease combined with cerebrovascular disease...
  89. ncbi The prevalence of peripheral arterial disease in high risk subjects and coronary or cerebrovascular patients
    Pavel Poredos
    Department of Vascular Diseases, University Medical Centre, Ljubljana, Slovenia
    Angiology 58:309-15. 2007
    ..In conclusion, our findings confirm a high prevalence of both symptomatic and asymptomatic PAD in patients at high cardiovascular risk and its association with both CAD and CVD...
  90. ncbi Brain perfusion abnormalities in patients with euthyroid autoimmune thyroiditis
    M Piga
    Nuclear Medicine, Department of Medical Sciences M Aresu, University of Cagliari, Cagliari, Italy
    Eur J Nucl Med Mol Imaging 31:1639-44. 2004
    ..Sixteen adult patients with HT entered this study following informed consent...
  91. ncbi CNS manifestations of Fabry's disease
    Andreas Fellgiebel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Lancet Neurol 5:791-5. 2006
    ..Cerebral vasculopathy, confirmed by neuropathological, neuroradiological, and functional studies, occurs commonly and leads to ischaemic cerebrovascular events at an early age...
  92. ncbi Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    Niels D Prins
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 128:2034-41. 2005
    ..Our results suggest that in older people cerebral small-vessel disease may contribute to cognitive decline by affecting information processing speed and executive function...
  93. ncbi Prognosis and management of patients with acute coronary syndrome and polyvascular disease
    Ignacio Ferreira-Gonzalez
    Area del Cor, Servicio de Cardiologia, Hospital Vall d Hebron, Barcelona, Espana
    Rev Esp Cardiol 62:1012-21. 2009
    ..To assess prognosis and patterns of care in patients with acute coronary syndrome and peripheral arterial disease (PAD), cerebrovascular disease or both (i.e., polyvascular disease) in everyday clinical practice...
  94. ncbi Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice
    Runa Araya
    Yamada Research Unit, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neurobiol Dis 24:334-44. 2006
    ..The M5 receptor may represent an attractive novel therapeutic target to ameliorate memory deficits caused by impaired cerebrovascular function...
  95. ncbi Cerebrovascular disorders
    James S Hutchison
    Department of Critical Care and Pediatrics, Hospital for Sick Children, and Interdepartmental Division of Critical Care, Faculty of Medicine, University of Toronto, Toronto, Canada
    Semin Pediatr Neurol 11:139-46. 2004
    ..Children with acute stroke should be rapidly transported to and cared for in a pediatric center with a specialized stroke team or access to acute stroke protocols...
  96. pmc Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
    M E Calhoun
    Department of Neuropathology, Institute for Pathology, University of Basel, CH 4003 Basel, Switzerland
    Proc Natl Acad Sci U S A 96:14088-93. 1999
    ..APP23 mice on an App-null background developed a similar degree of both plaques and CAA, providing further evidence that a neuronal source of APP/Abeta is sufficient to induce cerebrovascular amyloid and associated neurodegeneration...
  97. pmc Cerebrovascular disease and stroke
    J Pappachan
    Department of Paediatric Intensive Care, Child Health Directorate, Southampton General Hospital, Southampton, UK
    Arch Dis Child 93:890-8. 2008
    Stroke and cerebrovascular disorders are important causes of morbidity and mortality in children; they are already amongst the top 10 causes of childhood death and are probably increasing in prevalence...
  98. ncbi Relationship of vascular risk to the progression of Alzheimer disease
    B Borroni
    Neurology 68:1083-4; author reply 1084. 2007
  99. ncbi Incidence of dementia and associated risk factors in Japan: The Osaki-Tajiri Project
    Kenichi Meguro
    Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Japan
    J Neurol Sci 260:175-82. 2007
    ..A comprehensive system including CDR, cognitive tests, and MRI, is recommended in community-based health policy planning...
  100. pmc AD brain pathology: vascular origins? Results from the HAAS autopsy study
    Lenore J Launer
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C 309 Bethesda, MD 20892, USA
    Neurobiol Aging 29:1587-90. 2008
    ..Our study suggests the burden of vascular and AD type lesions are independent of each other, and are consistent with an additive effect of the two types of lesions on cognitive impairment...
  101. ncbi Evolution of cerebral arteriopathies in childhood arterial ischemic stroke
    Nasuda Danchaivijitr
    Department of Radiology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Ann Neurol 59:620-6. 2006
    ..To investigate evolution of cerebral arteriopathy in children with arterial ischemic stroke (AIS) and its influence on recurrence...

Research Grants64

  1. CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKE
    Costantino Iadecola; Fiscal Year: 2013
    ..Ultimately, the results of the proposed studies may suggest novel mechanism-based approaches to prevent or treat the deleterious effects of this highly prevalent condition. ..
  2. Eicosanoids and carbon monoxide in neonatal cerebral microcirculation
    ALIE JOSEPH KANU; Fiscal Year: 2012
    ..advance our knowledge of cerebral blood flow regulation and identify targets for the development of new techniques as well as therapeutic agents for the long-term treatment of cerebrovascular disorders in newborns. (End of Abstract)
  3. Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging
    Farzaneh A Sorond; Fiscal Year: 2010
    ..for clinical trials of HIF-1 activators in a number of hypoxic-ischemic geritaric disorders, especially cerebrovascular disorders such as ischemia and vascular cognitive impairment, which pose a significant health burden in our aging ..
  4. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    Michal Toborek; Fiscal Year: 2013
    ..evidence that even moderate exercise can significantly contribute to brain regeneration in chronic cerebrovascular disorders. PUBLIC HEALTH RELEVANCE: Methamphetamine (METH) abuse results in a long-term impairment of vascular ..
  5. Calcium signaling in the cerebrovascular unit in health and disease
    Mark T Nelson; Fiscal Year: 2013
    ..normal brain function;by extension, dysfunction of Ca^* signaling dynamics contributes to cerebrovascular disorders. Each project studies overlapping elements of the biological system to form a whole...
  6. Non-contrast 4-D Dynamic MRA in Arteriovenous Malformation (AVM)
    DANNY JIONG JIONG WANG; Fiscal Year: 2013
    ..It will be useful not only for evaluation of AVMs, but also for other cerebrovascular disorders such as steno-occlusive diseases and cerebral aneurysms. !
  7. Arterial Spin Labeled Perfusion MRI in Acute Ischemic Stroke
    DANNY JIONG JIONG WANG; Fiscal Year: 2013
    ..It is a translational project with the goal to develop and validate an entirely noninvasive and quantitative MRI method for routine clinical evaluation of AIS as well as other cerebrovascular disorders.
  8. Vascular Smooth Muscle Notch Signaling in Arterial Patterning and Function
    Aaron Proweller; Fiscal Year: 2013
    ..abstract_text> ..
  9. POLYDRUG ABUSE IN WOMEN
    NANCY MELLO; Fiscal Year: 2000
    ..Polydrug abuse and cocaine dependence are also associated with life-threatening cardiovascular and cerebrovascular disorders, abnormalities of reproductive function and compromised fetal development...
  10. ACUTE BRAIN INJURY AFTER SUBARACHNOID HEMORRHAGE
    Joshua Bederson; Fiscal Year: 2001
    ..is to develop a program of laboratory research that parallels the clinical problems of patients with cerebrovascular disorders. One of the most important of these is the lack of treatment options for patients who have suffered a ..
  11. Effects of VEGF on Brain Tissue in vitro
    JEFFREY ROSENSTEIN; Fiscal Year: 2004
    ..As an angiogenic factor VEGF could have potential use in cerebrovascular disorders but may also have trophic effects upon astroglia and neurons...
  12. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2006
    ..While there is evidence, which suggests that smoking is a risk factor for the pathogenesis of cerebrovascular disorders, including stroke, mechanisms, which contribute to the development of cerebrovascular disorders remain ..
  13. A SYNERGIUM ON STROKE: Spurring Progress in Challenging Times
    Marc Fisher; Fiscal Year: 2010
    ..bring together key opinion leaders to discuss a range of important topics related to the entire gamut of cerebrovascular disorders. For each of the 7 themes to be discussed, the 3 co-chairs will invite 5 additional contributors of ..
  14. Metabolic Effects of Newer Antipsychotics in Older Pts
    Dilip Jeste; Fiscal Year: 2009
    ..experienced multidisciplinary team of investigators (including experts in metabolic, cardiovascular, and cerebrovascular disorders), and infrastructure support provided by an NIMH-funded Advanced Center for Interventions and Services ..
  15. A New Collagen Expressed Primarily in Brain Tissue
    JEANNE MYERS; Fiscal Year: 2002
    ..Furthermore, neurodegenerative diseases such as Alzheimer's, Parkinson's, cerebrovascular disorders, together with epilepsy and multiple sclerosis, constitute a major class of devastating conditions which ..
  16. CELLULAR BIOLOGY OF BRAIN MICROVESSELS
    Sami Harik; Fiscal Year: 1992
    ..The proposed research may provide scientific bases for rational therapy of cerebrovascular disorders, metabolic encephalopathies and neurodegenerative disorders such as Parkinson's Disease.
  17. MICROVASCULAR PERICYTES--CONTROL OF CEREBRAL BLOOD FLOW
    Ira Herman; Fiscal Year: 1992
    ..matrix protein and mRNA metabolism modulate cerebrovascular cell behavior, but may ultimately reveal the molecular and cellular mechanisms that control the anomalous flow of blood seen in patients with cerebrovascular disorders.
  18. PETT IN CEREBROVASCULAR DISORDERS OF NEWBORN INFANT
    DENIS ALTMAN; Fiscal Year: 1991
    ....
  19. Transgenic Murine Model of Brain Vascular Malformation
    Guo Yuan Yang; Fiscal Year: 2004
    ..This non-tumor angiogenesis rodent preparation will serve as a model of disordered human cerebral angiogenesis, leading relatively quickly to the ability to test new therapeutic approaches for cerebrovascular disorders.
  20. MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORS
    Raj Kalaria; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  21. GENETIC STUDIES OF ANEURYSMAL SUBARACHNOID HEMORRHAGE
    Mark Alberts; Fiscal Year: 2003
    ..This research project combined with the PI's background and expertise provide a wide range of patient-oriented mentorship opportunities in clinical and genetic research...
  22. Tryptophan Metabolism, Genes, and Major Depression
    David Steffens; Fiscal Year: 2007
    ..Results from this study will help inform future treatment studies using genetics and metabolomic technology. [unreadable] [unreadable] [unreadable]..
  23. Frontotemporal degeneration: a basis for clinical trials
    David Knopman; Fiscal Year: 2006
    ..abstract_text> ..
  24. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2006
    ..abstract_text> ..
  25. Treatment Outcome of Vascular Depression
    Yvette Sheline; Fiscal Year: 2005
    ..The proposed trial will provide information of value to the practitioner and also provide data to build a more comprehensive model of the prognostic impact of frontal-subcortical brain changes on the outcome of late-life depression. ..
  26. Vascular Depression: Longitudinal Followup
    Yvette I Sheline; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  27. PET Amyloid Plaque Imaging in Late Life Depression
    Yvette Sheline; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. Novel Brain Neuroimaging Markers of Age-Related Mobility Impairment
    Caterina Rosano; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. 3D CEREBRAL VESSEL LOCATION FOR SURGICAL PLANNING
    Elizabeth Bullitt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  30. Pilot Trial of Metformin in Amnestic MCI
    Jose A Luchsinger; Fiscal Year: 2010
    ....
  31. Prostanoid Receptors and Ischemic Brain Injury
    Costantino Iadecola; Fiscal Year: 2010
    ..abstract_text> ..
  32. Protein S: Neurovascular Protection in Stroke
    Berislav V Zlokovic; Fiscal Year: 2010
    ..B. Berk (Rochester) (Tyro 3 RTK-Akt signaling) and Dr. M. Chopp (Henry Ford) (rat stroke model). The results will provide mechanistic insights and test therapeutic agents that may be translated to improved therapy for ischemic stroke. ..
  33. Global vs. Focal Neuroimaging Markers of Dementia Risk
    Caterina Rosano; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. Role of COX-2 Gene Expression in Ischemic Brain Damage
    Costantino Iadecola; Fiscal Year: 2010
    ..abstract_text> ..
  35. MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCH
    Larry Goldstein; Fiscal Year: 2004
    ....
  36. Alzheimer's ABeta, Apolipoproteins & Blood-Brain Barrier
    Berislav Zlokovic; Fiscal Year: 2004
    ....
  37. 3D Image Guided Endovascular Surgery
    Elizabeth Bullitt; Fiscal Year: 2006
    ..Indeed, the methods to be developed under this proposal have the potential to change how endovascular procedures are performed throughout the body. ..
  38. Anticholinergic Drugs, Cognitive Deficits & Normal Aging
    Robert Nebes; Fiscal Year: 2006
    ..We will also examine whether the decrements that anticholinergic drugs produce in higher-level cognitive abilities are mediated through decreases in working memory, processing speed or inhibitory efficiency. ..
  39. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  40. 3D CEREBRAL VESSEL LOCATION FOR SURGICAL PLANNING
    Elizabeth Bullitt; Fiscal Year: 2001
    ..We propose a number of studies to evaluate the accuracy and utility of our approach, and we also propose new visualization methods to indicate the uncertainty of our symbolic descriptions of image objects. ..
  41. AGING, WHITE MATTER HYPERINTENSITIES & COGNITIVE DECLINE
    Robert Nebes; Fiscal Year: 2001
    ....
  42. Vascular factors, amyloid beta, and Alzheimer's disease
    Jose Luchsinger; Fiscal Year: 2004
    ..abstract_text> ..
  43. Noninvasive assessment of tumor malignancy
    Elizabeth Bullitt; Fiscal Year: 2010
    ....
  44. Neurovascular Coupling in Hypertension
    Costantino Iadecola; Fiscal Year: 2004
    ..The results of these studies will enhance our understanding of the effects of hypertension on the brain and may provide new insights into treatment strategies aimed at counteracting these detrimental actions. ..
  45. AGING BRAIN--CEREBROVASCULAR MECHANISM & AMYLOID BETA
    Berislav Zlokovic; Fiscal Year: 2003
    ..abstract_text> ..
  46. HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTS
    SHARI WALDSTEIN; Fiscal Year: 2008
    ..abstract_text> ..
  47. EXPERIMENTAL NEUROGENIC HYPERTENSION PROGRAM
    Costantino Iadecola; Fiscal Year: 2008
    ..The proposed studies are relevant to human diseases, such as hypertension-induced cognitive dysfunction, cardiovascular complications of sleep apnea, and cardiovascular diseases in post-menopausal women. ..
  48. MENTAL DISORDERS OF AGING--ANTIINFLAMMATION IN AD
    Gary Small; Fiscal Year: 2003
    ....
  49. Internat'l symposium:vascular neuroeffector mechanisms
    SUE DUCKLES; Fiscal Year: 2002
    ..We anticipate that all aspects of this conference will help to foster development of new directions and collaborations in the field. ..
  50. GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITY
    Richard Mayeux; Fiscal Year: 2002
    ....
  51. PORPHYRIA AND HUMAN HEME BIOSYNTHESIS
    Robert J Desnick; Fiscal Year: 2010
    ..Viable CEP mice should permit studies of the disease pathophysiology and future therapeutic endeavors. ..
  52. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..The final phase will study mechanisms of vascular protection afforded by aprotinin. The proposed study has the potential to reduce the risk of brain injury in children and adults undergoing heart surgery. ..
  53. Cerebrovascular risk factors and late-life suicide
    SAU MAN CHAN; Fiscal Year: 2007
    ..The correlation between clinical and radiopathological CVRFs as well as the relationship between burden of CVRFs and impaired ECFs will be worked out by correlation statistics. ..
  54. Conference on the Diagnosis of Multiple System Atrophy
    Sid Gilman; Fiscal Year: 2006
    ..This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria. [unreadable] [unreadable] [unreadable]..
  55. Latent Mobility Abnormalities and Disability
    Joe Verghese; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  56. Hemodynamics and Outcome in Pediatric Brain Injury
    MONICA VAVILALA; Fiscal Year: 2007
    ..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
  57. National Assessment of the Mortality and Morbidity Effects of Tropospheric Ozone
    Michelle L Bell; Fiscal Year: 2010
    ..The goal of this work is to provide policy-makers, scientists, and the public with a better understanding of how ozone affects health in order to aid more effective decisions regarding protection of human health. ..
  58. Heme oxygenase and cerebral vascular injury
    Helena Parfenova; Fiscal Year: 2008
    ..Better understanding of the mechanisms of postictal cerebral vascular dysfunction is needed to improve the long-term neurological outcome in human newborns. ..
  59. Pilot Study of an Internet-based Cognitive Stimulation Program in AIDS
    James Becker; Fiscal Year: 2008
    ..If this is true, then it means that people with mild forms of cognitive impairment may be able to help themselves to get better. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. Hemodynamic predictors of brain and cognitive aging
    Naftali Raz; Fiscal Year: 2005
    ....
  61. Use of Herbs and Dietary Supplements in Four Ethnicities
    Annette Fitzpatrick; Fiscal Year: 2005
    ..It may also be possible to test associations of specific herb/supplement use with specific clinical/subclinical conditions should adequate power be available. ..
  62. Cognitive reserve and age-related brain changes
    Adam Brickman; Fiscal Year: 2005
    ..Results from the study will provide important insights into the normal aging process and will yield valuable information towards understanding the underpinnings of age-associated pathologies. ..
  63. TISSUE VIABILITY IN STROKE BY SODIUM MR IMAGING
    Keith Thulborn; Fiscal Year: 2002
    ..abstract_text> ..
  64. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..