Summary: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.

Top Publications

  1. ncbi Cigarette smoking and progression of atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
    G Howard
    Department of Public Health Sciences of Wake Forest University, Winston Salem, NC 27157 1063, USA
    JAMA 279:119-24. 1998
  2. ncbi Inflammation in atherosclerosis
    Peter Libby
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 420:868-74. 2002
  3. pmc Atherosclerosis
    A J Lusis
    Department of Medicine, Biology Institute, University of California, Los Angeles 90095, USA
    Nature 407:233-41. 2000
  4. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
  5. pmc In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    Satish N Nadig
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Nat Med 16:809-13. 2010
  6. doi Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis
    Boda Zhou
    Cardiovascular Division, King s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK
    Cardiovasc Res 90:413-20. 2011
  7. ncbi High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 21:13-27. 2001
  8. ncbi Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
  9. ncbi Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    F Mach
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 394:200-3. 1998
  10. ncbi Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits
    Elsa C Chan
    Bernard O Brien Institute of Microsurgery, University of Melbourne, 42 Fitzroy Street, Fitzroy, Victoria 3065, Australia
    Cardiovasc Res 75:710-8. 2007

Detail Information

Publications314 found, 100 shown here

  1. ncbi Cigarette smoking and progression of atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
    G Howard
    Department of Public Health Sciences of Wake Forest University, Winston Salem, NC 27157 1063, USA
    JAMA 279:119-24. 1998
    ..Cigarette smoking is a powerful risk factor for incident heart disease and stroke, but the relationship of active and passive smoking with the progression of atherosclerosis has not been described...
  2. ncbi Inflammation in atherosclerosis
    Peter Libby
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 420:868-74. 2002
    ..Identifying the triggers for inflammation and unravelling the details of inflammatory pathways may eventually furnish new therapeutic targets...
  3. pmc Atherosclerosis
    A J Lusis
    Department of Medicine, Biology Institute, University of California, Los Angeles 90095, USA
    Nature 407:233-41. 2000
    ..It is now clear that atherosclerosis is not simply an inevitable degenerative consequence of ageing, but rather a chronic inflammatory condition that can be converted into an acute clinical event by plaque rupture and thrombosis...
  4. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
    ..Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality...
  5. pmc In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    Satish N Nadig
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Nat Med 16:809-13. 2010
    Transplant arteriosclerosis is the hallmark of chronic allograft dysfunction (CAD) affecting transplanted organs in the long term. These fibroproliferative lesions lead to neointimal thickening of arteries in all transplanted allografts...
  6. doi Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis
    Boda Zhou
    Cardiovascular Division, King s College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK
    Cardiovasc Res 90:413-20. 2011
    ..shown to be involved in cancer and neurological disease, HDACs are also found to play crucial roles in arteriosclerosis. This review summarizes the effects of HDACs and HDAC inhibitors on proliferation, migration, and apoptosis ..
  7. ncbi High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport
    A von Eckardstein
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 21:13-27. 2001
    ..Instead, the concentration of HDL subclasses, the mobilization of cellular lipids for efflux, and the kinetics of HDL metabolism are important determinants of RCT and the risk of atherosclerosis...
  8. ncbi Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
    ..The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins...
  9. ncbi Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    F Mach
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 394:200-3. 1998
    ..These data support the involvement of inflammatory pathways in atherosclerosis and indicate a role for CD40 signalling during atherogenesis in hyperlipidaemic mice...
  10. ncbi Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits
    Elsa C Chan
    Bernard O Brien Institute of Microsurgery, University of Melbourne, 42 Fitzroy Street, Fitzroy, Victoria 3065, Australia
    Cardiovasc Res 75:710-8. 2007
    ..We have now examined the action of the NADPH oxidase inhibitor apocynin, given via the adventitia, on the neointima formation and endothelial function in this model...
  11. pmc Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
    J Hester
    Nuffield Department of Surgical Sciences, Transplantation Research Immunology Group, University of Oxford, UK
    Am J Transplant 12:2008-16. 2012
    ..combined treatment with low-dose rapamycin and subtherapeutic T(reg) numbers on the development of transplant arteriosclerosis (TA) in human arterial grafts transplanted into immunodeficient BALB/cRag2(-/-) Il2rg(-/-) mice reconstituted ..
  12. doi Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses
    Junhong Gao
    Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Circulation 124:830-9. 2011
    The processes of arteriosclerosis, including atherosclerosis and vascular remodeling, are affected by interactions among numerous biological pathways such as responses to inflammation, oxidative stress, and endoplasmic reticulum stress...
  13. doi Probiotic therapy to men with incipient arteriosclerosis initiates increased bacterial diversity in colon: a randomized controlled trial
    Caroline Karlsson
    Food Hygiene, Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden
    Atherosclerosis 208:228-33. 2010
    ..This study aimed to clarify the microbial change in the intestinal microbiota in patients, with cardiovascular disease, consuming a drink with high numbers of live Lactobacillus plantarum...
  14. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    ..apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis...
  15. pmc Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
    Dennis Bruemmer
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, Warren Hall, Suite 24 130, 900 Veteran Avenue, Los Angeles, California 90095, USA
    J Clin Invest 112:1318-31. 2003
    ..These data suggest an important role for leukocyte-derived OPN in mediating Ang II-accelerated atherosclerosis and aneurysm formation...
  16. ncbi Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus
    J M Esdaile
    University of British Columbia, Vancouver, Canada
    Arthritis Rheum 44:2331-7. 2001
    ..We sought to determine to what extent the increase could not be explained by common risk factors...
  17. ncbi Interleukins in atherosclerosis: molecular pathways and therapeutic potential
    Jan H von der Thüsen
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Pharmacol Rev 55:133-66. 2003
    ..This may prove to be the real challenge for the development of interleukin-based anti-atherosclerotic therapies, once the mediators and their targets have been delineated...
  18. ncbi Adhesion molecules and atherogenesis
    Y Huo
    Department of Biomedical Engineering, University of Virginia, Health Science Center, Charlottesville, VA 22908, USA
    Acta Physiol Scand 173:35-43. 2001
    ..These data suggest that P-selectin, PSGL-1, VLA-4 and VCAM-1 are the most important adhesion molecules involved in monocyte recruitment to atherosclerotic lesions...
  19. ncbi Androgens and cardiovascular disease
    Peter Y Liu
    ANZAC Research Institute, Concord Hospital and Department of Medicine, University of Sydney, New South Wales, Australia
    Endocr Rev 24:313-40. 2003
  20. ncbi Mannheim intima-media thickness consensus
    P J Touboul
    Cerebrovasc Dis 18:346-9. 2004
    ..This will help to improve the power of studies incorporating IMT measurements and to facilitate the merging of large databases for meta-analyses...
  21. ncbi Adventitial progenitor cells contribute to arteriosclerosis
    Evelyn Torsney
    Department of Cardiac and Vascular Sciences, St George s Hospital Medical School, SW17 0RE London, UK
    Trends Cardiovasc Med 15:64-8. 2005
    Accumulating evidence indicates the involvement of vascular progenitor cells in the development of arteriosclerosis, including transplant arteriosclerosis, angioplasty-induced restenosis, vein graft atherosclerosis, and spontaneous ..
  22. ncbi Smad expression in human atherosclerotic lesions: evidence for impaired TGF-beta/Smad signaling in smooth muscle cells of fibrofatty lesions
    Natalia Kalinina
    Baker Medical Research Institute, Alfred Hospital, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 24:1391-6. 2004
    ..Our objective was to define the actions of TGF-beta during lesion progression in humans by examining the expression of Smads in relation to TGF-beta-mediated responses...
  23. ncbi Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis
    Karl B Lemström
    Cardiopulmonary Research Group, Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Circulation 105:2524-30. 2002
    Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors.
  24. ncbi Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, Belgium
    Circulation 109:1408-14. 2004
    ..However, the role of specific MMPs, such as MMP-9 and MMP-12, in atherosclerosis remains undefined...
  25. ncbi Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study
    Christie M Ballantyne
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, and Methodist DeBakey Heart Center, Houston, Tex 77030, USA
    Circulation 109:837-42. 2004
    ..Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a proinflammatory enzyme associated primarily with LDL...
  26. ncbi Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study
    A Elisabeth Hak
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 87:3632-9. 2002
    ..In women, positive associations between levels of testosterone and aortic atherosclerosis were largely due to adverse cardiovascular disease risk factors...
  27. pmc Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice
    J H Qiao
    Department of Medicine, Molecular Biology Institute, University of California, Los Angeles, USA
    Am J Pathol 150:1687-99. 1997
    ..The effects of the op mutation on atherogenesis may have resulted from decreased circulating monocytes, reduced tissue macrophages, or diminished arterial M-CSF...
  28. ncbi Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    L Gu
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 2:275-81. 1998
    ..Thus, MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder...
  29. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
    ..Therefore, although expression of both VCAM-1 and ICAM-1 is upregulated in atherosclerotic lesions, our data indicate that VCAM-1 plays a dominant role in the initiation of atherosclerosis...
  30. ncbi Predictors of the incident metabolic syndrome in adults: the Insulin Resistance Atherosclerosis Study
    Latha Palaniappan
    Stanford University Medical Center, Stanford, California 94305 5705, USA
    Diabetes Care 27:788-93. 2004
    ..To prospectively investigate predictors of the incident metabolic syndrome in nondiabetic adults...
  31. ncbi Molecular mechanisms of lysophosphatidic acid action
    Gabor Tigyi
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Prog Lipid Res 42:498-526. 2003
  32. ncbi Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission
    Antongiulio Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 88:2527-33. 2003
    ..The persistence of a metabolic syndrome, vascular damage, and atherosclerotic plaques after cortisol level normalization makes these subjects still at high cardiovascular risk despite disease remission...
  33. ncbi Chronic stress accelerates atherosclerosis in the apolipoprotein E deficient mouse
    Meena Kumari
    Department of Epidemiology and Public Health, International Centre for Health and Society, London, UK
    Stress 6:297-9. 2003
    ..These data suggest that chronic mild stress can induce or accelerate the development of atherosclerosis...
  34. pmc Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice
    M Leitges
    Max Planck Institute for Experimental Endocrinology, Hannover, Germany
    J Clin Invest 108:1505-12. 2001
    ..cell (SMC) accumulation is a key event in the development of atherosclerosis, including vein bypass graft arteriosclerosis. Because members of the protein kinase C (PKC) family signal cells to undergo proliferation, differentiation, ..
  35. pmc Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression
    Alireza Baradaran-Heravi
    Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Hum Mol Genet 21:2572-87. 2012
    ..We conclude that the SMARCAL1 annealing helicase buffers fluctuations in gene expression and that alterations in gene expression contribute to the penetrance of SIOD...
  36. ncbi Cardiovascular disease in chronic renal failure: pathophysiologic aspects
    Gerard M London
    Department of Nephrology, F H Manhes Hospital Center, Fleury Merogis, France
    Semin Dial 16:85-94. 2003
    ..left ventricular hypertrophy [LVH], cardiomyopathy) and disorders of the vascular system (atherosclerosis, arteriosclerosis), these two disorders being usually associated and interrelated...
  37. ncbi Novel anti-inflammatory actions of amlodipine in a rat model of arteriosclerosis induced by long-term inhibition of nitric oxide synthesis
    Chu Kataoka
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Physiol Heart Circ Physiol 286:H768-74. 2004
    Amlodipine (a new class of calcium channel antagonist) has been shown to limit the progression of arteriosclerosis and decrease the incidence of cardiovascular events...
  38. ncbi Brachio-ankle pulse wave velocity and cardio-ankle vascular index (CAVI)
    Tomoyuki Yambe
    Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Biomed Pharmacother 58:S95-8. 2004
    In order to diagnose arteriosclerosis in any part of the body, pulse wave velocity (PWV) measurement is a useful approach. However, it is considered that the technique of PWV measurement should be simplified...
  39. ncbi Correlation between brachial-ankle pulse wave velocity and arterial compliance and cardiovascular risk factors in elderly patients with arteriosclerosis
    Baoying Li
    Department of Geriatrics, Qi Lu Hospital of Shandong University, Jinan, PR China
    Hypertens Res 29:309-14. 2006
    ..ABI), capacitive arterial compliance (C1), and oscillatory arterial compliance (C2) in elderly patients with arteriosclerosis. We analyzed 160 elderly patients with arteriosclerosis...
  40. ncbi HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis
    Noriko Kuwahara
    Division of Hypertension and Nephrology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Cardiol 123:84-90. 2008
    ..Chronic inhibition of nitric oxide synthase (NOS) induces arteriosclerosis, while HMG-CoA reductase inhibitors (statins) have pleiotropic vascular protective effects besides ..
  41. doi Arteriosclerosis: rethinking the current classification
    Gregory A Fishbein
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arch Pathol Lab Med 133:1309-16. 2009
    b>Arteriosclerosis is the vascular disease that is the leading cause of mortality in industrialized countries...
  42. ncbi Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
    R L Reddick
    Department of Pathology, School of Medicine, University of North Carolina at Chapel Hill 27599 7525
    Arterioscler Thromb 14:141-7. 1994
  43. ncbi Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position
    G Subbanagounder
    Department of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 20:2248-54. 2000
  44. ncbi Ginkgo biloba (EGb 761) in arteriosclerosis prophylaxis
    Gunter Siegel
    Department of Neurophysiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Wien Med Wochenschr 157:288-94. 2007
    ..Furthermore, the significant increase in the vasodilator cAMP and cGMP concentration powerfully supports the maintenance of an open bypass...
  45. doi Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a predictor of coronary artery disease in type 2 diabetes
    Ayumu Hirata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Atherosclerosis 219:623-9. 2011
    ..The aim of the present study was to investigate the association between CAD and systemic arteriosclerosis by qualitative vascular ultrasonography.
  46. pmc Risk factors for colonic diverticular bleeding: a Westernized community based hospital study
    Antje Jansen
    Department of Gastroenterology, St Elisabeth Hospital, PO Box 580, 46225 Dorsten, Germany
    World J Gastroenterol 15:457-61. 2009
    ..To evaluate the risk factors-other than nonsteroidal anti-inflammatory drugs-for colonic diverticular bleeding in a westernized population...
  47. pmc Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the Mayo Clinic proteomic markers of arteriosclerosis study
    Charles X Kim
    Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e9065. 2010
    ..We examined differences in circulating levels of 47 novel protein markers of CVD in 2561 men and women of African-American (AA) and non-Hispanic White (NHW) ethnicity, enrolled at geographically distinct sites...
  48. ncbi Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability
    Z Mallat
    Institut National de la Sante et de la Recherche Medicale, INSERM U541, Institut Fédératif de Recherche Circulation Paris VII, Hopital Lariboisiere, Paris, France
    Circulation 104:1598-603. 2001
    ..Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties. Its expression and role in atherosclerosis, however, are unknown...
  49. doi Influence of serum high-molecular-weight and total adiponectin on arteriosclerosis in IgA nephropathy patients
    Yuko Iwasa
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Nephron Clin Pract 108:c226-32. 2008 form of this protein, but there have been no reports on the relationship between serum adiponectin and arteriosclerosis. The aim of our study was to determine whether HMW or total adiponectin levels are associated with ..
  50. ncbi Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice
    Tatsuro Ishida
    Donald W Reynolds Cardiovascular Clinical Research Center, Divisions of Cardiovascular Medicine and Gastroenterology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    J Biol Chem 279:45085-92. 2004
  51. doi Wild-type apo A-I and apo A-I(Milano) gene transfer reduce native and transplant arteriosclerosis to a similar extent
    Yingmei Feng
    Center for Molecular and Vascular Biology, Campus Gasthuisberg, University of Leuven, Herestraat, Belgium
    J Mol Med (Berl) 87:287-97. 2009
    ..In conclusion, the current head-to-head comparison indicates that human apo A-I(Milano) transfer is not superior compared to wild-type human apo A-I transfer...
  52. ncbi The pathophysiology of cigarette smoking and cardiovascular disease: an update
    John A Ambrose
    Comprehensive Cardiovascular Center, Saint Vincent Catholic Medical Centers of New York, New York, New York 10011, USA
    J Am Coll Cardiol 43:1731-7. 2004
    ..Recent experimental and clinical data support the hypothesis that cigarette smoke exposure increases oxidative stress as a potential mechanism for initiating cardiovascular dysfunction...
  53. pmc Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    Luigi Fontana
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:6659-63. 2004
    ..Based on a range of risk factors, it appears that long-term CR has a powerful protective effect against atherosclerosis. This interpretation is supported by the finding of a low carotid artery IMT...
  54. pmc The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation
    C A Cuff
    The Wistar Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 108:1031-40. 2001
    ..We conclude that CD44 plays a critical role in the progression of atherosclerosis through multiple mechanisms...
  55. ncbi Carotid artery intima-media thickness measured by ultrasonography in normal clinical practice correlates well with atherosclerosis risk factors
    D Baldassarre
    E Grossi Paoletti Center, Institute of Pharmacological Sciences, University of Milan, Italy
    Stroke 31:2426-30. 2000
  56. ncbi Expression of CYR61, an angiogenic immediate early gene, in arteriosclerosis and its regulation by angiotensin II
    Andres Hilfiker
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    Circulation 106:254-60. 2002
    The renin-angiotensin system is thought to be involved in development and progression of arteriosclerosis, thereby contributing to adverse cardiovascular events...
  57. ncbi Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages
    Robert J Aiello
    Pfizer Global Research and Development, Groton, Connecticut, USA
    Arterioscler Thromb Vasc Biol 22:630-7. 2002
    ..ABCA1 deficiency in macrophages, however, demonstrates the antiatherogenic properties of ABCA1 independent of plasma lipids and HDL levels...
  58. ncbi Site specificity of atherosclerosis: site-selective responses to atherosclerotic modulators
    Paul A VanderLaan
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Arterioscler Thromb Vasc Biol 24:12-22. 2004
  59. ncbi Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits
    P Alexandersen
    Center for Clinical and Basic Research, Ballerup, Denmark
    Circ Res 84:813-9. 1999
    ..Natural androgens inhibit aortic atherosclerosis in castrated male rabbits only partly through a lipid-mediated effect...
  60. ncbi DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis
    K Wenzel
    Department of Internal Medicine I, Charite, Humboldt University, Berlin, Germany
    Hum Genet 97:15-20. 1996
    ..Results suggest that these polymorphisms are associated with a higher risk for early severe atherosclerosis...
  61. ncbi Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability
    Z Mallat
    Institut National de la Sante et de la Recherche Medicale, Unité 541, et Institut Fédératif de Recherche Paris VII, Hopital Lariboisiere, France
    Circ Res 89:E41-5. 2001
    ..The full text of this article is available at
  62. ncbi The macrophage foam cell as a target for therapeutic intervention
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 8:1235-42. 2002
  63. ncbi New risk factors for atherosclerosis and patient risk assessment
    Jean Charles Fruchart
    Departement de Recherche sur les Lipoproteines et l Atherosclerose, Pasteur de Lille, Inserm U545 et Faculté de Pharmacie, université du droit et de la santé de Lille 2, Lille, France
    Circulation 109:III15-9. 2004
  64. ncbi The human mast cell: functions in physiology and disease
    G Krishnaswamy
    The Department of Medicine, East Tennessee State University, Johnson City, Tennessee 37614 1709, USA
    Front Biosci 6:D1109-27. 2001
    ..Drugs, such as glucocorticoids, cyclosporine and cromolyn have been demonstrated to have inhibitory effects on mast cell degranulation or mediator release...
  65. ncbi Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (AIR) study
    Johannes Hulthe
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Clin Sci (Lond) 103:123-9. 2002
    ..Thus, in clinically healthy middle-aged men, levels of sICAM-1, but not of soluble VCAM-1 or E-selectin, were associated with both subclinical atherosclerosis and inflammatory variables...
  66. pmc Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages
    E Brogi
    Vascular Medicine and Atherosclerosis Unit, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Clin Invest 92:2408-18. 1993
    ..normal arteries suggests that this growth factor may not contribute to cell proliferation in advanced atherosclerosis. However, aFGF produced by plaque macrophages may stimulate the growth of microvessels during human atherogenesis...
  67. pmc Emerging relations between infectious diseases and coronary artery disease and atherosclerosis
    I W Fong
    Department of Medicine, St Michael s Hospital, Toronto, Ont
    CMAJ 163:49-56. 2000
    ..The results of large randomized clinical trials in progress will help establish causality and the benefits of antimicrobial therapy in CAD...
  68. pmc Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice
    Galina K Sukhova
    the Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 111:897-906. 2003
    ..CatS(-/-)LDLR(-/-) monocytes showed impaired subendothelial basement membrane transmigration, and aortas from CatS(-/-)LDLR(-/-) mice had preserved elastic laminae. These findings establish a pivotal role for Cat S in atherogenesis...
  69. ncbi Indirect allorecognition can play an important role in the development of transplant arteriosclerosis
    Stephan M Ensminger
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Transplantation 73:279-86. 2002
    ..Our aim was to develop an animal model that allowed the contribution of the direct and indirect pathway of allorecognition in the evolution of transplant arteriosclerosis, the main feature of chronic allograft rejection, to be evaluated.
  70. ncbi Accelerated atherosclerosis: an extraarticular feature of rheumatoid arthritis?
    S Van Doornum
    The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Arthritis Rheum 46:862-73. 2002
  71. pmc Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
    J D Smith
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:8264-8. 1995
    ..The data support the hypothesis that macrophage colony-stimulating factor and its effects on macrophage development and function play a key role in atherogenesis...
  72. ncbi Atherosclerosis and extracellular matrix
    Shogo Katsuda
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    J Atheroscler Thromb 10:267-74. 2003
    ..Accumulating information on the molecular regulation of ECM synthesis and degradation will help investigators attain a more thorough understanding of the mechanisms of plaque formation and plaque instability and rupture...
  73. ncbi Requirement for CD154 in the progression of atherosclerosis
    E Lutgens
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, P Debeyeln 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Nat Med 5:1313-6. 1999
    ..These data indicate that CD40-CD154 signaling is important in late atherosclerotic changes, such as lipid core formation and plaque destabilization...
  74. ncbi Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women
    Yvonne T van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 22:1316-22. 2002
    ..Phytoestrogens have been postulated to protect against cardiovascular diseases, but few studies have focused on the effect of Western dietary phytoestrogen intake...
  75. ncbi Four-year follow-up of Palmaz-Schatz stent revascularization as treatment for atherosclerotic renal artery stenosis
    G Dorros
    William Dorros Isadore Feuer Interventional Cardiovascular Disease, Foundation Ltd, Milwaukee, Wis, USA
    Circulation 98:642-7. 1998
    ..Stent revascularization is perceived as superior to balloon angioplasty and surgical revascularization, but the paucity of stent publications precludes even historical comparison with surgical data...
  76. ncbi Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness
    Séverine Durier
    Department of Pharmacology and INSERM EMI 107, Paris, France
    Circulation 108:1845-51. 2003
  77. ncbi Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    Nature 394:894-7. 1998
    ..These data reveal a role for MCP-1 in the development of early atherosclerotic lesions and suggest that upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation...
  78. ncbi Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican
    Ann Cathrine Jönsson-Rylander
    Department of Molecular Pharmacology, AstraZeneca, R and D, Molndal, Sweden
    Arterioscler Thromb Vasc Biol 25:180-5. 2005
    ..We investigated the potential role of ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motif type I) in atherogenesis...
  79. ncbi B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice
    Chiara Buono
    Immunology Research Division and the Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 109:2009-15. 2004
    ..This study tested the hypothesis that the ability of T cells to influence atherosclerosis depends on B7-1/B7-2 costimulation...
  80. ncbi A role for oxidized phospholipids in atherosclerosis
    Judith A Berliner
    David Geffen School of Medicine, University of California, Los Angeles, USA
    N Engl J Med 353:9-11. 2005
  81. ncbi Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering
    C P Sparrow
    Merck Research Laboratories, Rahway, NJ, USA
    Arterioscler Thromb Vasc Biol 21:115-21. 2001
    ..These data support the hypothesis that simvastatin has antiatherosclerotic activity beyond its plasma cholesterol-lowering activity...
  82. ncbi Allograft vasculopathy versus atherosclerosis
    Maziar Rahmani
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Providence Research Institute, Vancouver, British Columbia, Canada
    Circ Res 99:801-15. 2006
    ..b>Arteriosclerosis is a broad term that is used to encompass all diseases that lead to arterial hardening, including native ..
  83. ncbi Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study
    Markus Juonala
    Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 110:2918-23. 2004
    ..We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults...
  84. ncbi Interferon-gamma elicits arteriosclerosis in the absence of leukocytes
    G Tellides
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, and the Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 403:207-11. 2000
    Atherosclerosis and post-transplant graft arteriosclerosis are both characterized by expansion of the arterial intima as a result of the infiltration of mononuclear leukocytes, the proliferation of vascular smooth muscle cells (VSMCs) and ..
  85. pmc Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis
    Su Li Cheng
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    Circ Res 107:271-82. 2010
    Vascular fibrosis and calcification contribute to diabetic arteriosclerosis, impairing Windkessel physiology necessary for distal tissue perfusion...
  86. ncbi Clinical importance of endothelial function in arteriosclerosis and ischemic heart disease
    Kensuke Egashira
    Department of Cardiovascular Medicine, School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ J 66:529-33. 2002
    ..Vascular endothelial function is an important and clinically relevant therapeutic target for cardiovascular disease...
  87. ncbi Accelerated arteriosclerosis of vein grafts in inducible NO synthase(-/-) mice is related to decreased endothelial progenitor cell repair
    Ursula Mayr
    Department of Cardiac and Vascular Sciences, St George s University of London, London SW17 0RE, United Kingdom
    Circ Res 98:412-20. 2006
    ..Previously, we have established a mouse model for vein graft arteriosclerosis by grafting autologous jugular veins or vena cava to carotid arteries...
  88. ncbi Chronic transplant dysfunction and transplant arteriosclerosis: new insights into underlying mechanisms
    Jan Luuk Hillebrands
    Department of Cell Biology, Immunology Section, Faculty of Medical Sciences, University of Groningen, MWF bldg 3215, A Deusinglaan 1, NL 9713 AV, Groningen, The Netherlands
    Expert Rev Mol Med 5:1-23. 2003
    ..The development of this transplant vasculopathy,referred to as transplant arteriosclerosis (TA), is a multifactorial process and many risk factors have been identified...
  89. ncbi Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo
    Kenji Yoshida
    Department of Neuroscience, Osaka University Graduate School of Medicine D13, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 108:1746-52. 2003
    ..CONCLUSIONS: This is the first report demonstrating a role for a naturally occurring unsaturated LPA in inducing vascular remodeling in vivo and provides a novel animal model for neointimal formation...
  90. ncbi The mysteries of lipoprotein(a)
    G Utermann
    Institute for Medical Biology and Genetics, University of Innsbruck, Austria
    Science 246:904-10. 1989
    ..Though of high theoretical and practical interest, many aspects of the metabolism, function, evolution, and regulation of plasma concentrations of Lp(a) are presently unknown, controversial, or mysterious...
  91. ncbi [Pulse pressure in the diagnosis of arteriosclerosis]
    Kenji Takazawa
    Second Department of Internal Medicine, Tokyo Medical University
    Nihon Rinsho 62:249-52. 2004
  92. doi Inhibition of TNF-alpha reduces transplant arteriosclerosis in a murine aortic transplant model
    Martina Wollin
    Department for Internal Medicine 3 and Institute for Clinical Immunology, University Erlangen Nurnberg, Erlangen, Germany
    Transpl Int 22:342-9. 2009
    ..The data show that TNF-alpha blockade using infliximab can reduce the development of transplant arteriosclerosis in fully mismatched murine aortic grafts.
  93. doi Vascular smooth muscle cell apoptosis promotes transplant arteriosclerosis through inducing the production of SDF-1α
    J Li
    Division of Liver Transplantation, Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Am J Transplant 12:2029-43. 2012
    Transplant arteriosclerosis is a leading cause of late allograft loss. Medial smooth muscle cell (SMC) apoptosis is considered to be an important event in transplant arteriosclerosis...
  94. ncbi From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1664-72. 2003
    ..We encourage healthcare policy makers to promote translational research for screening and treatment of vulnerable patients...
  95. ncbi Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
    D S Celermajer
    Cardiothoracic Unit, Hospital for Sick Children, London, UK
    Lancet 340:1111-5. 1992
    ..This may be an important early event in atherogenesis...
  96. pmc IFN-gamma potentiates atherosclerosis in ApoE knock-out mice
    S Gupta
    Department of Medicine, Columbia University, New York 10032, USA
    J Clin Invest 99:2752-61. 1997
    ..Therefore, therapeutic inhibition of IFN-gamma signaling may lead to the formation of more lipid-poor and stable atheromata...
  97. ncbi [Inflammatory mechanisms, arteriosclerosis and ischemic stroke: clinical data and perspectives]
    L C Alvaro-González
    Servicio de Nurología, Hospital de Basurto, Bilbao, Espana
    Rev Neurol 35:452-62. 2002
    ..The ischemic atherotrombotic stroke is the most frequent form of the last one. In this sense we review herein the mechanisms underlying the artherosclerotic process...
  98. pmc Monocyte angiotensin converting enzyme expression may be associated with atherosclerosis rather than arteriosclerosis in hemodialysis patients
    Christof Ulrich
    Department of Internal Medicine II, Martin Luther University, Halle Wittenberg, Germany
    Clin J Am Soc Nephrol 6:505-11. 2011
    ..Cardiovascular morbidity results from atherosclerosis (plaque-forming, vessel occluding disease) and arteriosclerosis (loss of arterial dampening function)...
  99. pmc Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm
    Hiroki Tanaka
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 8:e57398. 2013
    ..The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease...
  100. ncbi ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    Y Nakashima
    Department of Pathology, University of Washington, Seattle 98195
    Arterioscler Thromb 14:133-40. 1994
    ..This model should provide numerous opportunities to study the pathogenesis and therapy of atherosclerosis in a small, genetically defined animal...
  101. pmc Establishing baseline criteria of cardio-ankle vascular index as a new indicator of arteriosclerosis: a cross-sectional study
    Tsukasa Namekata
    Pacific Rim Disease Prevention Center, P O Box 25444, Seattle, WA 98165 2344, USA
    BMC Cardiovasc Disord 11:51. 2011
    A cardio-ankle vascular index (CAVI) has been developed to represent the extent of arteriosclerosis throughout the aorta, femoral artery and tibial artery independent of blood pressure...

Research Grants71

  1. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
  2. Transplacental Arsenic Induced Hepatic Dysfunction and Vascular Disease
    J Christopher States; Fiscal Year: 2010 adult life, as suggested by reports of infant deaths from myocardial infarction caused by advanced arteriosclerosis in regions where mothers consumed water with high levels of arsenic...
  3. PET Imaging of Myocardial Oxidative Stress in T2DM
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..stress secondary to increased ROS is central to pathogenesis various cardiovascular diseases including arteriosclerosis, hypertension, and heart failure...
  4. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..result in unacceptable morbidity including speech and swallowing defects, shoulder dysfunction, accelerated arteriosclerosis of the carotid, xerostomia, trismus, lymphedema and neck muscle fibrosis...
  5. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..This proposal may improve the application of anti-atherosclerosis agents and lead to development of new agents to protect blood vessels from atherosclerosis and its complications. ..
  6. CEACAM1: A link between metabolic and cardiovascular diseases
    Sonia M Najjar; Fiscal Year: 2013
    ..Answering these questions will delineate new CEACAM1-dependent mechanisms underlying atherosclerosis along the liver/endothelial cell axis, and pinpoint sites of pharmacologic intervention. ..
  7. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2013
  8. Calcification and Vascular Cell Differentiation
    Cecilia M Giachelli; Fiscal Year: 2013
    ..associated with hypertension, cardiac valve disease, artificial heart valve calcification, and other forms of arteriosclerosis. It leads to cardiac valve stenosis, increased pulse pressure, hypertension and may contribute to plaque ..
  9. Role of NOD2 in Inflammatory Arthritis and Innate Immunity
    MICHAEL PATRICK DAVEY; Fiscal Year: 2012
    ..Understanding how NOD2 controls the development of inflammation leading to tissue injury and pathology will have broad implications for the health of veterans. ..
    Sergio Fazio; Fiscal Year: 2013
    ..We strive to understand the factors that regulate bulk plaque regression. ..
  11. Integrin-dependent mechanism of T cell-mediated pulmonary fibrosis
    Irina G Luzina; Fiscal Year: 2012
    ..or fibrosis, plays a pivotal role in various diseases of the lungs, liver, and kidneys, in wound granulation, arteriosclerosis and in chronic inflammation in all organs...
  12. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2010
    ..y due to accelerated vascular disease ("transplant arteriosclerosis") as the result of vascular endothelial and smooth muscle cell proliferation...
  13. Effect of White Matter Disease on Gait and Balance in Cerebral Amyloid Angiopathy
    Anand Viswanathan; Fiscal Year: 2013
    ..abstract_text> ..
  14. Vascular Function, Cognition, and Brain MRI in Atherosclerotic Vascular Disease
    David J Moser; Fiscal Year: 2012
    ..We have published cross-sectional findings in Stroke and in Arteriosclerosis, Thrombosis, and Vascular Biology showing that this measure of vascular function is significantly related to ..
  15. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..immune response to the allograft demonstrate increased risk of antibody-mediated rejection and transplant arteriosclerosis. HLA class I and class II signaling pathways have been implicated in this process because ligation of class I ..
  16. Subclinical Renal Artery Atherosclerosis, Kidney Function and Hypertension
    Matthew A Allison; Fiscal Year: 2011
    ..Specifically, arteriosclerosis of the preglomerular arterioles leads to relative renal ischemia and subsequent activation of the rennin-..
  17. The Fat1 Cadherin in Atherosclerotic Vascular Disease
    NICHOLAS E SIBINGA; Fiscal Year: 2013
    ..important vascular diseases such as atherosclerosis, restenosis, coronary artery bypass graft failure, and arteriosclerosis that occurs in transplanted hearts and kidneys...
  18. T-type Calcium Channels and Aldosterone Secretion
    Paula Q Barrett; Fiscal Year: 2013
    ..heart, kidneys, and vasculature by advancing disease processes such as cardiac fibrosis, nephrosclerosis and arteriosclerosis. Although aldosterone induced cardiovascular and renal damage has been associated with the activation of the ..
  19. Role of PLAB1B in the Development of Hyperlipidemia Associated Atherosclerosis
    NORRIS ISAAC HOLLIE; Fiscal Year: 2013
    ..Furthermore, the effect of Pla2g1b competence upon atherosclerosis development and systemic inflammation will be investigated in a mouse model of diet-induced atherosclerosis. ..
    Dwight A Towler; Fiscal Year: 2012
    ..Strategies that reduce aortofemoral arteriosclerosis and maintain vascular compliance will improve tissue perfusion, and mitigate amputation risk...
  21. Chronic DTH and IFN-gamma in Human Graft Arteriosclerosis
    Jordan S Pober; Fiscal Year: 2010
    ..The overall goals of this PPG remain largely unchanged, namely to elucidate the pathogenesis graft arteriosclerosis (GA), the major cause of late cardiac allograft failure, in order to develop new strategies to prevent, treat ..
  22. Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis
    Emmanouil Brilakis; Fiscal Year: 2013
  23. Immunodominant Stress Proteins of Porphyromonas gingivalis
    Dennis E Lopatin; Fiscal Year: 2010
    ..pylori infections and arteriosclerosis. The long-term goals of this work is to deliniate the mechanisms of chaperone involvement in periodontitis ..
  24. TRPC Channels in the Metabolic Syndrome
    Alexander G Obukhov; Fiscal Year: 2013
    ..Importantly, we will determine the distinct roles of TRPC1 and TRPC6 during MetS-associated NATIVE atherosclerosis progression. ..
  25. PCSK9, Lipoprotein receptors, and Atherosclerosis
    Sergio Fazio; Fiscal Year: 2013
    ..We are proposing to investigate these correlations in detail and to evaluate the overall impact of PCSK9 expression on lipoprotein receptors and atherosclerosis. ..
  26. Iron and Atherosclerosis
    Subha V Raman; Fiscal Year: 2013
    ..This research tests the theory that monthly loss of iron through menses is protective against atherosclerosis, which could lead to an entirely new approach to preventing and treating heart and vascular disease in both men and women. ..
    Robert D Goldman; Fiscal Year: 2010
    ..with characteristics of premature aging that include loss of subcutaneous fat, wrinkled skin, loss of hair, arteriosclerosis, and difficulty in moving joints...
  28. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2010
    ..Undesired platelet activation is a result of many common pathologies, e.g. hypertension and arteriosclerosis, and leads to excessive platelet aggregation and the generation of occlusive thrombi (thrombosis)...
  29. Prasugrel for prevention of early saphenous vein graft thrombosis
    Emmanouil Brilakis; Fiscal Year: 2013
  30. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arteriosclerosis is the chronic disease state characterized by thickening and hardening of arterial walls with loss of elasticity...
  31. Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIV
    STEVEN KYLE GRINSPOON; Fiscal Year: 2013
    ..In addition, the potential beneficial effects of a cholesterol-lowering medication on vascular inflammation and immune cells will be investigated in HIV patients with early asymptomatic atherosclerosis. (End of Abstract) ..
  32. Pyrophosphate in vascular calcification of renal failure
    W CHARLES O apos NEILL; Fiscal Year: 2010
    ..This calcification occurs in the media of large and small arteries and is also known as Monckeberg's arteriosclerosis. In addition to causing or contributing to ischemic events, the calcification can decrease arterial ..
    Devendra K Agrawal; Fiscal Year: 2013
    ..Information obtained from this study should provide an opportunity to formulate superior therapeutic approaches in the prevention of stroke. ..
  34. Connexin 43 gap junction dynamics in the diabetic heart
    Joseph A Palatinus; Fiscal Year: 2013
    ..This project will provide a better understanding of the fundamental mechanism of diabetic heart disease and may lead to new treatments beyond blood pressure and sugar control. ..
  35. Regulation of the early events of platelet activation
    Lawrence F Brass; Fiscal Year: 2013 thrombosis and to the evolution and consequences of common diseases of the vessel wall including arteriosclerosis. Although a great deal is known about platelet activation, much less is known about the events within ..
  36. CRIC Ancillary Study: Carbamylated low-density lipoprotein and cardiovascular eve
    Sudhir V Shah; Fiscal Year: 2011
    ..the utility of a nontraditional risk factor, serum cLDL, as a risk factor associated with cardiac events and arteriosclerosis in patients with CKD utilizing the wealth of information from the CRIC Study...
  37. HDL prevention of cholesterol crystal inflammation in HIV disease
    Eicke Latz; Fiscal Year: 2013
    ..Such biomarkers will help in the search for therapeutic targets to reduce cardiovascular disease in the context of HIV infection and likely in the general population. ..
    Wang Min; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The overall hypothesis of this application is that graft arteriosclerosis (GA), the major cause of late cardiac allograft failure, results from a chronic hot T cell response to allogeneic graft ..
  39. Phase II Trial of Lonafarnib, Pravastatin and Zoledronic Acid in Progeria
    MARK WILLIAM KIERAN; Fiscal Year: 2010
    ..Children die at a median age of 13 years due to heart attacks and strokes caused by accelerated, global arteriosclerosis. The HGPS mutation lies within the LMNA gene, which codes for the protein, lamin A, which is expressed in all ..
  40. KLF4, myeloid development, and transplantation arteriosclerosis
    A K M KHYRUL WARA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Transplantation-associated arteriosclerosis (TAA) is the major cause of morbidity and death in recipients who survive more than one year after heart transplantation...
  41. The macro- and micro- anatomy and pathology of the aging kidney
    ANDREW DAVID RULE; Fiscal Year: 2013
    ..nephrosclerosis as characterized by glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis). Both occur with age, but little is known about their relationship to each other...
  42. Role of Star Proteins in Bile Acid and Cholesterol Metabolism
    William M Pandak; Fiscal Year: 2012
    ..An understanding of the mechanisms of regulation of cholesterol homeostasis in hepatocytes and macrophages is very relevant to the understanding of the development of arteriosclerosis and heart disease in humans.
  43. Imaging of atheroma macrophage activities by rational liposomal shell design
    Patrick Kee; Fiscal Year: 2013
    ..If successful, this will compliment existing imaging technologies and allow better characterization of coronary lesions and patient management. ..
  44. Factor XIII Activation and Substrate Specificity
    Muriel C Maurer; Fiscal Year: 2010
    ..details is critical considering the role of FXIII in increasing the risk of heart disease, stroke, and arteriosclerosis. The specific aims are an extension of ongoing studies and will address three hypotheses: 1) The reactive ..
  45. KLF10, T regulatory cells, and atherogenesis
    Mark W Feinberg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Arteriosclerosis and its complications are the leading cause of morbidity and mortality in Western Societies...
  46. Research Training in Renal Diseases
    WILLIAM EVANS MITCH; Fiscal Year: 2013
    ..Research areas include mechanisms causing CVD (lipid metabolism, diabetic complications, arteriosclerosis, the cell biology of heart fibrosis and neointima development in vein grafts)...
  47. Regulating Anti-Endothelial T Cell Responses in Graft Arteriosclerosis
    Jordan S Pober; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Graft arteriosclerosis (GA), the major cause of late cardiac allograft failure, is untreatable so that improved clinical outcomes will depend upon prevention...
    Samuel A Wickline; Fiscal Year: 2013
    ..These will be tested in vivo in mouse models as single agent and combination therapies. ..
  49. Fortilin, p53, and atherosclerosis
    Ken Fujise; Fiscal Year: 2013
    ..At the end of the project, we expect M[unreadable]-specific anti-fortilin therapy to be found to be a ground-breaking strategy against the deadly and global disease of atherosclerosis. ..
  50. G-Quadruplex-Mediated Transcriptional Regulation of PDGFR-??
    Danzhou Yang; Fiscal Year: 2013
    ..of PDGFR-beta is an important factor in pancreatic cancer as well as other inflammatory diseases, including arteriosclerosis and therefore is a highly significant molecular target...
  51. Membrane targeting of Kindlin 3: mechanisms and role in integrin activation
    Julia Meller; Fiscal Year: 2012
    ..strategies to inhibit integrin activation for treatment of a number of pathological conditions including coagulative disorders, stroke, ischemic heart disease, arteriosclerosis, immune disorders, cancer and metastasis.
  52. Plaque Regression and Progenitor Cell Mobilization with Intensive Lipid Eliminati
    Subhash Banerjee; Fiscal Year: 2013
    ..therapy will significantly reduce the total atheroma volume of vulnerable plaque and augment mobilization of peripherally circulating EPC-CFU/ml, compared to guideline based standard statin monotherapy alone (SMT) 1 ..
  53. Intravascular Fluorescence Molecular Imaging of Inflammation in Atherosclerosis
    Farouc Jaffer; Fiscal Year: 2013
    ..The Proposal builds on established large animal catheter-based imaging efforts in the Investigator's laboratory and leverages established engineering, imaging, and biological expertise from a multidisciplinary team. ..
  54. Stiffness, cadherins, and integrins in mechanochemical signaling
    Christopher S Chen; Fiscal Year: 2013
    ..response, provide novel approaches to study these complex adhesive and mechanical effects both in vivo and in vitro, and may suggest new therapeutic strategies to interrupt the progression of restenosis and arteriosclerosis.
  55. A Genome-Wide Association Study of Ischemic Brain Vascular Injury
    Myriam Fornage; Fiscal Year: 2010
    ..including the Genes Associated with Stroke Risk and Outcomes Study (GASROS) and the Genetic Network Of Arteriosclerosis (GENOA)...
  56. A research and drug development tool for the real time in vitro study of single c
    Angelo Gaitas; Fiscal Year: 2013
    ..These findings may help to develop new therapies for cancer, arteriosclerosis, and autoimmune diseases, like rheumatoid arthritis...
    Trevor J Orchard; Fiscal Year: 2013
    ..Advances in noninvasive methods of measuring atherosclerosis and arteriosclerosis have changed the field of CV epidemiology by providing more precise and useful phenotypes for CVD expression...
  58. Identification of small molecule furin-like protease inhibitors
    JULIA COPPOLA; Fiscal Year: 2009
    ..yellow fever, SARS-CoV, anthrax, botulinum, measles, pseudomonas, shigella, diphtheria, arthritis, arteriosclerosis, Alzheimer's disease, and malignant cancer...
  59. Sparstolonin B as an anti-atherogenic agent
    Daping Fan; Fiscal Year: 2013
    ..The confirmation of the hypothesis will usher the development of SsnB as a new anti-atherogenic agent;it will also provide a pharmacological evidence for the causal role of TLR2 and TLR4 signaling in atherogenesis. ..
    David Chappell; Fiscal Year: 1991
    ..affecting this interaction may involve either the receptor or the lipoprotein ligands and lead to accelerated arteriosclerosis. This is the case in two hereditary disorders, familial hypercholesterolemia, in which the apo-B,E(LDL) ..
  61. Clinical Implications of Peripheral Plaque Morphology
    Daniel Clair; Fiscal Year: 2007
    ..non-responders. The completion of these three investigations should yield a validated, high resolution, real time imaging study with which to assess risk and base treatment decisions in patients with PAD. ..
  62. GATA Factor Regulation of Vascular Endothelium
    EMERY BRESNICK; Fiscal Year: 2009
    ..Human GATA2 polymorphisms correlate with coronary artery disease, GATA-2 expression is linked to arteriosclerosis, and GATA-2 regulates genes encoding the vascular molecules endothelin-1 and vascular adhesion molecule-1...
  63. Primary Prevention of Hypertension in Obese Adolescents
    Daniel Feig; Fiscal Year: 2006
  64. Brain and Spinal Cord Microvascular Pathology in Late-Life Motor Impairment
    Aron S Buchman; Fiscal Year: 2013
  65. Measurement of arterial mechanical properties during plaque progression
    SEEMANTINI NADKARNI; Fiscal Year: 2009
    ..Completion of this work will result in the determination of a key biomechanical marker associated with plaque instability and will move us towards the eventual goal of identifying high-risk plaques in patients. ..
  66. Serum fatty acids and ischemic stroke in women
    Ka He; Fiscal Year: 2009
    ..One explanatory hypothesis for the paradoxical observations is that arteriosclerosis in different types of cerebral arteries has different causal patterns...
    Lynne Johnson; Fiscal Year: 2000
    ..b>Arteriosclerosis of the coronary arteries is a major health problem in the US and a leading cause of death...
    Souvik Sen; Fiscal Year: 2004
    ..Designing of future placebo controlled prospective studies aimed at investigating measures that may be used to treat AA in stroke/TIA patients. ..
  69. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2009
    b>Arteriosclerosis (i.e...
  70. Heme Oxygenase-1: protection against chronic rejection
    FRITZ BACH; Fiscal Year: 2009
    ..expression of heme oxygenase-1 (HO-1) before the transplant and for a short period thereafter can suppress arteriosclerosis. Similar data are available for models of atherosclerosis...
    Robert Knopp; Fiscal Year: 2002
    ..Physicians have an impression that diet is ineffective in preventing arteriosclerosis, in part because nutrition education is fragmented and inconsistent in medical schools despite nationwide ..