coronary disease

Summary

Summary: An imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Top Publications

  1. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  2. ncbi Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project
    R M Conroy
    Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Eur Heart J 24:987-1003. 2003
  3. ncbi Quantification of coronary artery calcium using ultrafast computed tomography
    A S Agatston
    Mount Sinai Medical Center, Miami Beach, Florida 33140
    J Am Coll Cardiol 15:827-32. 1990
  4. pmc Collaborative care for patients with depression and chronic illnesses
    Wayne J Katon
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    N Engl J Med 363:2611-20. 2010
  5. ncbi Explaining the decrease in U.S. deaths from coronary disease, 1980-2000
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 356:2388-98. 2007
  6. ncbi Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  7. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
  8. ncbi Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
    Bernard De Bruyne
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Aalst, Belgium
    N Engl J Med 367:991-1001. 2012
  9. ncbi Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
    R B D'Agostino
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    JAMA 286:180-7. 2001
  10. ncbi Adherence to a Mediterranean diet and survival in a Greek population
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    N Engl J Med 348:2599-608. 2003

Detail Information

Publications260 found, 100 shown here

  1. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  2. ncbi Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project
    R M Conroy
    Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Eur Heart J 24:987-1003. 2003
    ..The SCORE project was initiated to develop a risk scoring system for use in the clinical management of cardiovascular risk in European clinical practice...
  3. ncbi Quantification of coronary artery calcium using ultrafast computed tomography
    A S Agatston
    Mount Sinai Medical Center, Miami Beach, Florida 33140
    J Am Coll Cardiol 15:827-32. 1990
    ..Ultrafast computed tomography is an excellent tool for detecting and quantifying coronary artery calcium...
  4. pmc Collaborative care for patients with depression and chronic illnesses
    Wayne J Katon
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    N Engl J Med 363:2611-20. 2010
    ..We conducted a study to determine whether coordinated care management of multiple conditions improves disease control in these patients...
  5. ncbi Explaining the decrease in U.S. deaths from coronary disease, 1980-2000
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 356:2388-98. 2007
    ..We conducted a study to determine how much of this decrease could be explained by the use of medical and surgical treatments as opposed to changes in cardiovascular risk factors...
  6. ncbi Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  7. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  8. ncbi Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
    Bernard De Bruyne
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Aalst, Belgium
    N Engl J Med 367:991-1001. 2012
    ....
  9. ncbi Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
    R B D'Agostino
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    JAMA 286:180-7. 2001
    ..Concern exists regarding whether these functions can be generalized to other populations...
  10. ncbi Adherence to a Mediterranean diet and survival in a Greek population
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    N Engl J Med 348:2599-608. 2003
    ..Adherence to a Mediterranean diet may improve longevity, but relevant data are limited...
  11. ncbi Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
    ..We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD)...
  12. ncbi Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    C Baigent
    Lancet 366:1267-78. 2005
    ..But each separate trial has limited power to assess particular outcomes or particular categories of participant...
  13. ncbi Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    N Engl J Med 354:1264-72. 2006
    ..We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population...
  14. ncbi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
    ..However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups...
  15. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  16. ncbi HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
    Philip Barter
    Heart Research Institute, Sydney, Australia
    N Engl J Med 357:1301-10. 2007
    ..High-density lipoprotein (HDL) cholesterol levels are a strong inverse predictor of cardiovascular events. However, it is not clear whether this association is maintained at very low levels of low-density lipoprotein (LDL) cholesterol...
  17. ncbi Effects of torcetrapib in patients at high risk for coronary events
    Philip J Barter
    Heart Research Institute, Camperdown, Sydney, NSW, Australia
    N Engl J Med 357:2109-22. 2007
    ..We investigated whether torcetrapib, a potent CETP inhibitor, might reduce major cardiovascular events. The trial was terminated prematurely because of an increased risk of death and cardiac events in patients receiving torcetrapib...
  18. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
    ..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
  19. ncbi Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Germany
    Circulation 105:310-5. 2002
    ..Although several scoring schemes have been suggested to calculate this profile, many omit information on important variables such as family history of coronary heart disease or LDL cholesterol...
  20. pmc Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies
    Rachel Huxley
    George Institute for International Health, University of Sydney, PO Box M201, Sydney, NSW 2050, Australia
    BMJ 332:73-8. 2006
    ..To estimate the relative risk for fatal coronary heart disease associated with diabetes in men and women...
  21. ncbi Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese Multi-Provincial Cohort Study
    Jing Liu
    Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
    JAMA 291:2591-9. 2004
    ..Recalibration of Framingham functions could permit various regions of the world to adapt Framingham tools to local populations...
  22. ncbi Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis
    Jurgen Barth
    Department of Rehabilitation Psychology, Institute of Psychology, University of Freiburg, Germany
    Psychosom Med 66:802-13. 2004
    ..The relative risk in meta-analytic aggregation is 1.64 (confidence interval [CI], 1.29-2.08) for any CHD event. However, the adverse impact of depression on CHD patients has not yet been the subject of a meta-analysis...
  23. pmc Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
    Mary A Whooley
    VA Medical Center, San Francisco, California, USA
    JAMA 300:2379-88. 2008
    ..Depressive symptoms predict adverse cardiovascular outcomes in patients with coronary heart disease, but the mechanisms responsible for this association are unknown...
  24. pmc Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies
    Marianne U Jakobsen
    Research Unit for Dietary Studies at the Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark
    Am J Clin Nutr 89:1425-32. 2009
    ..Lower habitual intakes of SFAs, however, require substitution of other macronutrients to maintain energy balance...
  25. ncbi Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials
    Rod S Taylor
    Department of Epidemiology and Public Health, University of Birmingham, Birmingham, United Kingdom
    Am J Med 116:682-92. 2004
    ..To review the effectiveness of exercise-based cardiac rehabilitation in patients with coronary heart disease...
  26. ncbi Work stress in the etiology of coronary heart disease--a meta-analysis
    Mika Kivimaki
    Finnish Insitute of Occupational Health, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    Scand J Work Environ Health 32:431-42. 2006
    ..This study focused on estimating the relative risk of coronary heart disease (CHD) in association with work stress, as indicated by the job-strain model, the effort-reward imbalance model, and the organizational injustice model...
  27. ncbi Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study
    M De Lorgeril
    Explorations Fonctionnelles Cardiorespiratoires et Métaboliques, CHU de Saint Etienne, France
    Circulation 99:779-85. 1999
    ..This report presents results of an extended follow-up (with a mean of 46 months per patient) and deals with the relationships of dietary patterns and traditional risk factors with recurrence...
  28. ncbi Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:2518-28. 2009
    ..The genetic determinants of the Lp(a) lipoprotein level and their relevance for the risk of coronary disease are incompletely understood.
  29. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
    ..Our project has developed resources and methods that address both admixture- and SNP-association to maximize power for genetic discovery in even larger African-American consortia...
  30. ncbi DS14: standard assessment of negative affectivity, social inhibition, and Type D personality
    Johan Denollet
    Medical Psychology, Department of Psychology and Health, Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands
    Psychosom Med 67:89-97. 2005
    ..This study reports on the Type D Scale-14 (DS14) as a standard measure of NA, SI, and Type D...
  31. ncbi Mendelian randomization: prospects, potentials, and limitations
    George Davey Smith
    Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol BS8 2PR
    Int J Epidemiol 33:30-42. 2004
  32. ncbi Adolescent BMI trajectory and risk of diabetes versus coronary disease
    Amir Tirosh
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 364:1315-25. 2011
    ..The association of body-mass index (BMI) from adolescence to adulthood with obesity-related diseases in young adults has not been completely delineated...
  33. pmc Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000252. 2010
    ..Additionally, some public health groups recommend lowering or limiting polyunsaturated fat (PUFA) consumption, a major potential replacement for SFA...
  34. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  35. ncbi Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 112:2627-33. 2005
    ..Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate within the normal range may also be associated with adverse outcomes...
  36. doi Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on
    Judith H Lichtman
    Circulation 118:1768-75. 2008
    ..This multispecialty consensus document reviews the evidence linking depression with CHD and provides recommendations for healthcare providers for the assessment, referral, and treatment of depression...
  37. ncbi Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 344:1959-65. 2001
    ..We hypothesized that statins might prevent coronary events in persons with elevated C-reactive protein levels who did not have overt hyperlipidemia...
  38. pmc Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies
    Alexander Thompson
    Lp PLA2 Studies Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:1536-44. 2010
    ..We investigated associations of circulating Lp-PLA(2) mass and activity with risk of coronary heart disease, stroke, and mortality under different circumstances...
  39. ncbi The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease
    Pia Pajunen
    National Public Health Institute, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 12:132-7. 2005
    ....
  40. ncbi Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    Shaista Malik
    Heart Disease Prevention Program, University of California, Irvine 92697, USA
    Circulation 110:1245-50. 2004
    ..We examined the impact of MetS on CHD, CVD, and overall mortality among US adults...
  41. pmc Socioeconomic position, co-occurrence of behavior-related risk factors, and coronary heart disease: the Finnish Public Sector study
    Mika Kivimaki
    Department of Epidemiology and Public Health, University College London, London, UK
    Am J Public Health 97:874-9. 2007
    ..We examined the associations between socioeconomic position, co-occurrence of behavior-related risk factors, and the effect of these factors on the relative and absolute socioeconomic gradients in coronary heart disease...
  42. ncbi EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries
    Kornelia Kotseva
    Department of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Eur J Cardiovasc Prev Rehabil 16:121-37. 2009
    ....
  43. ncbi Diagnosis and treatment of depression following routine screening in patients with coronary heart disease or diabetes: a database cohort study
    C Burton
    Centre for Population Health Sciences, University of Edinburgh, UK
    Psychol Med 43:529-37. 2013
    ..Depression is common in chronic illness and screening for depression has been widely recommended. There have been no large studies of screening for depression in routine care for patients with chronic illness...
  44. ncbi Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations
    K Kuulasmaa
    Department of Epidemiology and Health Promotion, National Public Health Institute KTL, Helsinki, Finland
    Lancet 355:675-87. 2000
    ..We assessed the extent to which changes in these risk factors explain the variation in the trends in coronary-event rates across the populations...
  45. ncbi AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute
    Sidney C Smith
    Circulation 113:2363-72. 2006
  46. ncbi Serum γ-glutamyltransferase: independent predictor of risk of diabetes, hypertension, metabolic syndrome, and coronary disease
    Altan Onat
    Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Obesity (Silver Spring) 20:842-8. 2012
    ..Higher serum total bilirubin levels were protective against CHD risk in women. We conclude that elevated serum GGT confers, additively to BMI, risk of hypertension, MetS, and type 2 diabetes but only mediates adiposity against CHD risk...
  47. pmc Talking about depression: a qualitative study of barriers to managing depression in people with long term conditions in primary care
    Peter A Coventry
    Greater Manchester Collaboration for Leadership in Applied Health Research and Care, Health Sciences Research Group and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
    BMC Fam Pract 12:10. 2011
    ..The aim of this study was to identify and explore barriers to detecting and managing depression in primary care in people with two exemplar LTCs: diabetes and coronary heart disease (CHD)...
  48. ncbi Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies
    Amanda Nicholson
    Department of Epidemiology and Public Health, University College London Medical School, 1 19 Torrington Place, London WC1E 6BT, UK
    Eur Heart J 27:2763-74. 2006
    ..We quantified the effect of depression on CHD, assessing the extent of confounding by coronary risk factors and disease severity...
  49. ncbi Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment
    Benjamin J Ansell
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 108:2751-6. 2003
    ..The inflammatory/antiinflammatory properties of HDL were compared with HDL cholesterol in 2 groups of patients and in age- and sex-matched control subjects...
  50. pmc Contribution of modern cardiovascular treatment and risk factor changes to the decline in coronary heart disease mortality in Scotland between 1975 and 1994
    S Capewell
    University of Glasgow, Department of Public Health, 2 Lilybank Gardens, Glasgow G12 8RZ, UK
    Heart 81:380-6. 1999
    ..To estimate the fall in coronary heart disease (CHD) mortality in Scotland attributable to medical and surgical treatments, and risk factor changes, between 1975 and 1994...
  51. pmc Coronary artery calcium score and risk classification for coronary heart disease prediction
    Tamar S Polonsky
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 303:1610-6. 2010
    ..The coronary artery calcium score (CACS) has been shown to predict future coronary heart disease (CHD) events. However, the extent to which adding CACS to traditional CHD risk factors improves classification of risk is unclear...
  52. ncbi Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
    ..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis...
  53. ncbi C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    John Danesh
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 350:1387-97. 2004
    ..We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease...
  54. ncbi Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the ARMYDA-ACS randomized trial
    Giuseppe Patti
    Department of Cardiovascular Sciences, Campus Bio Medico University, Rome, Italy
    J Am Coll Cardiol 49:1272-8. 2007
    ..This study sought to investigate potential protective effects of atorvastatin in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI)...
  55. ncbi Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?
    Philipp Saiko
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Mutat Res 658:68-94. 2008
    ..oxidation, and suppression of platelet aggregation, thereby strongly supporting its role in the prevention of coronary disease. Promising data within the use of RV have also been obtained regarding progressive neurodegenerative maladies ..
  56. ncbi Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Circulation 112:3375-83. 2005
    ....
  57. ncbi Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlle
    D A Wood
    Department of Cardiovascular Medicine, National Heart and Lung Institute at Charing Cross Campus, Imperial College, London, UK
    Lancet 371:1999-2012. 2008
    ..Our aim was to investigate whether a nurse-coordinated multidisciplinary, family-based preventive cardiology programme could improve standards of preventive care in routine clinical practice...
  58. ncbi Coronary heart disease in China
    X H Zhang
    Department of Community and Family Medicine, School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Heart 94:1126-31. 2008
    ..The studies provide important information for the prevention and management of chronic CHD and acute myocardial infarction in the Chinese population...
  59. ncbi Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies
    Ka He
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1102, Chicago, Ill 60611, USA
    Circulation 109:2705-11. 2004
    ..Results from observational studies on fish consumption and coronary heart disease (CHD) mortality are inconsistent...
  60. ncbi Job strain and major risk factors for coronary heart disease among employed males and females in a Swedish study on work, lipids and fibrinogen
    Lars Alfredsson
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Work Environ Health 28:238-48. 2002
    ..The aim of this study was to analyze the relationship of job strain (high psychological job demands and low decision latitude) to hypertension, serum lipids, and plasmafibrinogen...
  61. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  62. ncbi Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Am Coll Cardiol 50:2128-32. 2007
    ..The objective of our study was to examine age-specific mortality rates from coronary heart disease (CHD), particularly those among younger adults...
  63. ncbi Major risk factors as antecedents of fatal and nonfatal coronary heart disease events
    Philip Greenland
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    JAMA 290:891-7. 2003
    ....
  64. ncbi Coronary heart disease mortality trends in the Netherlands 1972-2007
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht STR 6 131, GA Utrecht, The Netherlands
    Heart 97:569-73. 2011
    ..Coronary heart disease (CHD) mortality has steadily declined since the early 1970s in the Netherlands. However, in some Western countries the rate of decline in younger groups may be starting to plateau or even rise...
  65. ncbi Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 303:1841-7. 2010
    ..Coronary heart disease (CHD) mortality has declined substantially in Canada since 1994...
  66. ncbi Depression as a predictor for coronary heart disease. a review and meta-analysis
    Reiner Rugulies
    Division of Occupational and Environmental Medicine, University of California, San Francisco, USA
    Am J Prev Med 23:51-61. 2002
    ..To review and quantify the impact of depression on the development of coronary heart disease (CHD) in initially healthy subjects...
  67. pmc A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses
    Samuli Ripatti
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland mm fi
    Lancet 376:1393-400. 2010
    ..We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design...
  68. ncbi Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review
    Lawson R Wulsin
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Psychosom Med 65:201-10. 2003
    The objectives of this study were to systematically review the recent studies of the contribution of depression to the onset of coronary disease and to estimate the magnitude of the risk posed by depression for onset of coronary disease.
  69. ncbi Best-practice interventions to reduce socioeconomic inequalities of coronary heart disease mortality in UK: a prospective occupational cohort study
    Mika Kivimäki
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 372:1648-54. 2008
    ..We assessed this issue in an occupational cohort study comparing low with high socioeconomic groups...
  70. pmc Low prevalence of "ideal cardiovascular health" in a community-based population: the heart strategies concentrating on risk evaluation (Heart SCORE) study
    Claudia Bambs
    University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circulation 123:850-7. 2011
    ..The applicability of this construct to community-based populations and the distributions of its components by race and sex have not been reported...
  71. ncbi The decline in coronary heart disease mortality is slowing in young adults (Australia 1976-2006): a time trend analysis
    Martin O'Flaherty
    University of Liverpool, Liverpool, United Kingdom
    Int J Cardiol 158:193-8. 2012
    ..To examine whether the recent flattening of mortality rates for coronary heart disease (CHD) observed among young adults in the UK and the US is also occurring in the Australian population...
  72. pmc Collaborative Interventions for Circulation and Depression (COINCIDE): study protocol for a cluster randomized controlled trial of collaborative care for depression in people with diabetes and/or coronary heart disease
    Peter A Coventry
    Greater Manchester Collaboration for Leadership in Applied Health Research and Care, Institute of Population Health and Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Trials 13:139. 2012
    ..The study also aimed to evaluate the cost-effectiveness of the intervention over 6 months, and to assess qualitatively the extent to which collaborative care was implemented in the intervention general practices...
  73. ncbi Optimal medical therapy with or without PCI for stable coronary disease
    William E Boden
    Western New York Veterans Affairs Healthcare Network and Buffalo General Hospital SUNY, Buffalo, NY 14203, USA
    N Engl J Med 356:1503-16. 2007
    ....
  74. ncbi Explaining the increase in coronary heart disease mortality in Beijing between 1984 and 1999
    Julia Critchley
    International Health Research Group, Liverpool School of Tropical Medicine, UK
    Circulation 110:1236-44. 2004
    ..We examined how much of the increase in CHD mortality in Beijing, China, between 1984 and 1999 could be attributed to changes in major cardiovascular risk factors and assessed the impact of medical and surgical treatments...
  75. ncbi Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms
    Robert M Carney
    Department of Psychiatry, Suite 420, Behavioral Medicine Center, Washington University School of Medicine, 4625 Lindell Boulevard, St Louis, MO 63108, USA
    J Psychosom Res 53:897-902. 2002
    ..behavioral and physiological mechanisms that might explain how depression increases the risk for incident coronary disease and for subsequent cardiac morbidity and mortality. The candidate mechanisms include: (1)...
  76. ncbi A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect
    Jianqing Zhou
    Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China
    Thromb Res 130:602-6. 2012
    ..have revealed a significant association between four new risk loci and coronary heart disease (CHD) in Europeans and South Asians. The goal of this study is to evaluate the contribution of these genetic loci to CHD risk in Han Chinese...
  77. pmc Low-density lipoproteins containing apolipoprotein C-III and the risk of coronary heart disease
    Carlos O Mendivil
    Harvard School of Public Health, Department of Nutrition, 665 Huntington Avenue, Boston, MA 02115, USA
    Circulation 124:2065-72. 2011
    ..Low-density lipoprotein (LDL) that contains apolipoprotein (apo) C-III makes up only 10% to 20% of plasma LDL but has a markedly altered metabolism and proatherogenic effects on vascular cells...
  78. ncbi Modelling the decreasing coronary heart disease mortality in Sweden between 1986 and 2002
    Lena Björck
    Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Eur Heart J 30:1046-56. 2009
    ....
  79. pmc Association of glycemic index and glycemic load with risk of incident coronary heart disease among Whites and African Americans with and without type 2 diabetes: the Atherosclerosis Risk in Communities study
    Dale S Hardy
    Division of Epidemiology, University of Texas School of Public Health, Houston, TX 77225, USA
    Ann Epidemiol 20:610-6. 2010
    ..In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes...
  80. ncbi The use of fractional polynomials to model continuous risk variables in epidemiology
    P Royston
    Department of Medical Statistics and Evaluation, Imperial College School of Medicine, London, UK
    Int J Epidemiol 28:964-74. 1999
    ..The traditional method of analysing continuous or ordinal risk factors by categorization or linear models may be improved...
  81. pmc Dietary glycemic load and glycemic index and risk of coronary heart disease and stroke in Dutch men and women: the EPIC-MORGEN study
    Koert N J Burger
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 6:e25955. 2011
    ..The associations of glycemic load (GL) and glycemic index (GI) with the risk of cardiovascular diseases (CVD) are not well-established, particularly in men, and may be modified by gender...
  82. ncbi A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women
    S Liu
    Departments of Epidemiology and Nutrition, The Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 71:1455-61. 2000
    ..Little is known about the effects of the amount and type of carbohydrates on risk of coronary heart disease (CHD)...
  83. ncbi Dietary glycemic load and index and risk of coronary heart disease in a large italian cohort: the EPICOR study
    Sabina Sieri
    Nutritional Epidemiology Unit, Fondazione IRCCS Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy
    Arch Intern Med 170:640-7. 2010
    ....
  84. ncbi Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
    ..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain...
  85. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  86. ncbi Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study
    Robert N Foley
    United States Renal Data System, Minneapolis, MN 55404, USA
    Am Heart J 156:556-63. 2008
    ..Calcium-phosphate levels, linked to vascular dysfunction in chronic kidney disease, may represent novel risk factors for coronary heart disease, stroke, and death in community-dwelling adults...
  87. ncbi Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    N Engl J Med 348:109-18. 2003
    ..Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear...
  88. pmc Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study
    Marianna Virtanen
    Finnish Institute of Occupational Health, Centre of Expertise for Work Organizations, Topeliuksenkatu 41 aA, FIN 00250 Helsinki, Finland
    Eur Heart J 31:1737-44. 2010
    ..To examine the association between overtime work and incident coronary heart disease (CHD) among middle-aged employees...
  89. ncbi n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Am J Clin Nutr 77:319-25. 2003
    ....
  90. pmc Explaining the decrease in coronary heart disease mortality in Italy between 1980 and 2000
    Luigi Palmieri
    National Centre of Epidemiology, Surveillance, and Promotion of Health, National Institutes of Health, 00162 Rome, Italy
    Am J Public Health 100:684-92. 2010
    ..We examined the extent to which the decrease in coronary heart disease (CHD) mortality rates in Italy could be explained by changes in cardiovascular risk factors versus the use of medical and surgical treatments...
  91. ncbi Perceived job stress and incidence of coronary events: 3-year follow-up of the Belgian Job Stress Project cohort
    Dirk De Bacquer
    Department of Public Health, Ghent University, Ghent, Belgium
    Am J Epidemiol 161:434-41. 2005
    ..However, our study underscores the importance of a supportive social work environment in the prevention of coronary heart disease...
  92. ncbi Independent association of HbA(1c) and incident cardiovascular disease in people without diabetes
    Robert J Adams
    University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville, South Australia, Australia
    Obesity (Silver Spring) 17:559-63. 2009
    ..Unlike previous studies, this relationship was not substantially attenuated by other traditional risk factors...
  93. ncbi Effect of PCI on quality of life in patients with stable coronary disease
    William S Weintraub
    Christiana Care Health System, Newark, DE 19718, USA
    N Engl J Med 359:677-87. 2008
    ..It has not been clearly established whether percutaneous coronary intervention (PCI) can provide an incremental benefit in quality of life over that provided by optimal medical therapy among patients with chronic coronary artery disease...
  94. ncbi Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils o
    Gary J Balady
    Boston University Medical Center, USA
    Circulation 115:2675-82. 2007
    ....
  95. ncbi HDL biogenesis and functions: role of HDL quality and quantity in atherosclerosis
    Eirini M Tsompanidi
    University of Patras Medical School, Department of Medicine, Pharmacology Unit, Rio, TK, Greece
    Atherosclerosis 208:3-9. 2010
    ..In addition, we discuss the significance of both HDL quality and quantity in assessing cardiovascular risk...
  96. pmc Contribution of high plasma triglycerides and low high-density lipoprotein cholesterol to residual risk of coronary heart disease after establishment of low-density lipoprotein cholesterol control
    Vincent J Carey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 106:757-63. 2010
    ..Thus, high TGs might have greater importance in patients with optimal rather than greater LDL cholesterol concentrations...
  97. ncbi Fetal origins of adult disease: strength of effects and biological basis
    D J P Barker
    Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
    Int J Epidemiol 31:1235-9. 2002
    ....
  98. ncbi Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study
    Olga A Iakoubova
    Celera, Alameda, California 9450, USA
    J Am Coll Cardiol 51:449-55. 2008
    ..We explored whether the benefit of intensive versus moderate statin therapy would be greater in carriers of KIF6 719Arg than in noncarriers...
  99. ncbi Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials
    Olga A Iakoubova
    Celera, Inc, Alameda, California 94502, USA
    J Am Coll Cardiol 51:435-43. 2008
    ....
  100. ncbi A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study
    Dov Shiffman
    Celera, Alameda, California 94502, USA
    J Am Coll Cardiol 51:444-8. 2008
    ..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women...

Research Grants68

  1. Purkinje Origin of Ischemic Ventricular Tachycardia and Fibrillation
    James B Martins; Fiscal Year: 2013
    ..The ultimate goal will be to develop new, effective therapies to prevent ischemic VT/VF in patients with coronary disease, particularly in Veterans...
  2. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..shown to have increased susceptibility to viral infections, allergic and autoimmune responses and premature coronary disease. Although data have established negative psychological and overall health responses, the biological pathways ..
  3. Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zipper
    Xing Ming Shi; Fiscal Year: 2012
    ..Since excess belly fat increases the risks of coronary disease and causes insulin resistance, both of which are major public health threats, understanding how PPAR(2 ..
  4. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..It will determine the importance of novel biomarkers to predict the risk of adverse events in clinical practice. ..
  5. Role of Oleylethanolamine in the Regulation of the HPT Axis
    Csaba Fekete; Fiscal Year: 2010
    ..prevalent condition in both the United States and Hungary, associated with diabetes, high blood pressure, coronary disease and cancer. There are few effective anti-obesity treatments...
  6. Hydrogen Peroxide and Flow-Induced Dilation of Human Coronary Microcirculation
    David D Gutterman; Fiscal Year: 2012
    ..Our recent data indicate that flow-mediated dilation (FMD) occurs in coronary arterioles from patients with coronary disease but operates through a novel mechanism involving endothelial production of reactive oxygen species (ROS) ..
  7. Control of embryonic development by CK2: CK2 as a core Wnt/beta-catenin component
    María Isabel Domínguez; Fiscal Year: 2013
    ..is linked to human diseases and disorders such as sex reversal, tetramelia, osteoporosis, cancer, obesity and coronary disease. Research in the past two decades has resulted in the discovery of many Wnt/b-catenin components and in the ..
  8. Establishment of a bioresource for discovery and evaluation of genetic and other
    Danish Saleheen; Fiscal Year: 2010
    ..GWAS) of stroke in European populations;(iii) evaluation in RACE samples of 20 SNPs previously linked with coronary disease risk and/or cardiovascular risk factors (eg, APOE, chr 9p21.3, chr 1p13...
  9. Thrombosis Genetics, MI and Stroke in Older Adults
    Alexander P Reiner; Fiscal Year: 2012
    ..benefits of anti-thrombotic therapies suggest a major role for clotting and inflammation in the etiology of coronary disease and stroke, the specific genetic determinants that underlie the predisposition toward vascular inflammation ..
  10. Treatment and Risk Factor Determinants of Cardiovascular Outcomes in BARI 2D
    Maria Mori Brooks; Fiscal Year: 2013
    ..coronary artery disease and type 2 diabetes mellitus are at higher risk for cardiac events than those with coronary disease but no history of diabetes...
  11. Markers of the metabolic syndrome linking type 2 diabetes and MI in South Asia
    Danish Saleheen; Fiscal Year: 2010
    ..We will perform assay related to diabetes, lipid metabolism and coronary disease in the Pakistan Risk of Myocardial Infarction Study (PROMIS)...
  12. Novel Biomarkers to Identify Vulnerable Patients with Coronary Artery Disease
    Marc S Sabatine; Fiscal Year: 2012
    ..pathobiologically relevant pathways plus proteins and metabolites not previously suspected to play a role in coronary disease but identified and validated through unbiased investigative approaches offers the best chance to develop a ..
  13. Community Exercise and Metabolic Syndrome in Black Families
    Diane M Becker; Fiscal Year: 2012
    ..on the metabolic syndrome and its components in high risk people from African Americans with premature coronary disease. Outcomes will include changes in factors that affect cardiovascular risk...
  14. Exercise, Diabetes, &Coronary Smooth Muscle Ca2+
    Michael Sturek; Fiscal Year: 2013
    ..Drugs currently approved for humans are very likely to find new uses in treatment of coronary disease. We are uniquely positioned to benefit the prevention and regression of coronary disease, which will improve ..
  15. DIETARY ETIOLOGIES OF HEART DISEASE AND CANCER
    Eric B Rimm; Fiscal Year: 2013
    ..to assess blood and genetic markers of oxidation and identify participants at highest risk of incident coronary disease in an ongoing 22-year prospective study of over 50,000 male health professionals...
  16. Antibodies to Define Molecular Mechanisms of Hypertriglyceridemia
    Stephen G Young; Fiscal Year: 2010
    ..have shown that accelerated rates of lipolysis lead to lower plasma lipid levels and a reduced prevalence of coronary disease. Molecular imaging to define intracapillary levels of GPIHBP1 and LPL will lead to a vastly improved ..
  17. IVUS Detection of Rupture Prone Plaques
    Marvin M Doyley; Fiscal Year: 2013
    ..Coronary angiography, the "gold standard" employed to assess the severity of coronary disease in symptomatic patients, reveals only the degree of luminal narrowing, and fails to visualize the arterial ..
  18. Stents and Antiplatelet Drugs: Impact on Ischemia and Bleeding in the Elderly
    Samip Vasaiwala; Fiscal Year: 2011
    ..The elderly, those older than 65 years of age, are more likely to have coronary disease and this problem will become even more pervasive as the population ages...
  19. Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms
    Alexei Bogdanov; Fiscal Year: 2009
    ..suggests that the elevated presence of myeloperoxidase (MPO) in blood is an important risk factor for coronary disease and atherosclerotic plaque rupture...
  20. SFRP2, cell survival, and coronary vascular angiogenesis
    DOROTHY EILEEN VATNER; Fiscal Year: 2013
    ..potentially a novel mediator of cardiac protection conferred by chronic ischemia, as occurs in patients with coronary disease. Our preliminary data indicate that over expression of sFRP2 significantly increases angiogenesis and ..
  21. Molecular Regulation of CC Chemokine in Atherosclerosis and Aging
    Raymond L Yung; Fiscal Year: 2010
    ..the resulting increased leukocyte chemokine receptor expression in turn contributes to the high prevalence of coronary disease in the elderly...
  22. ApoE and SR-BI as Determinants of HDL and Macrophage Function in Atherogenesis
    Macrae F Linton; Fiscal Year: 2010
    ..in dyslipidemia, characterized by large free cholesterol (FC)-enriched HDL particles, accelerated occlusive coronary disease, and premature death due to myocardial infarction...
  23. Mechanism of Flow-Induced Dilation in the Human Microcirculation
    David D Gutterman; Fiscal Year: 2013
    ..Aging or the presence of coronary disease (CAD) and its risk factors can change these mediators of dilation...
  24. Efferocytosis in CVD & Inflammation
    EDWARD BENJAMIN THORP; Fiscal Year: 2010
    ..Interestingly, preliminary data also suggest that advanced coronary disease in humans coincides with proteolytic degradation of Mertk...
  25. A Novel Magnetic Resonance Imaging Marker of Myocardial Fibrosis
    Michael Jerosch-Herold; Fiscal Year: 2013
    ..research plan is based on MRI studies in patients diagnosed with aortic stenosis with no previous history of coronary disease, who will undergo aortic valve replacement...
  26. Cooperative Lifestyle Intervention Programs (CLIP-II)
    WALTER JOHN REJESKI; Fiscal Year: 2013
    ..Experts have argued that the primary goal of medical care for older adults who have coronary disease should be to improve physical function and to extend disability-free survival...
  27. Inflammation, Cardiac Sympathetic Innervation and Arrhythmic Sudden Death
    RICHARD THOMAS GEORGE; Fiscal Year: 2012
    ..Experimental and clinical evidence has established that inflammation plays a critical role in stable coronary disease, plaque rupture, acute myocardial infarction, heart failure, and SCD...
  28. PATHOPHYSIOLOGY OF MYOCARDIAL DISEASE
    DAVID ALAN KASS; Fiscal Year: 2013
    ..association research, preventive medicine strategies, clinical/translational studies in electrophysiology, coronary disease, and heart failure, and cardiovascular aging...
  29. Flat Panel X-ray Sources for Small Animal Cardiac CT
    Mitali J More; Fiscal Year: 2010
    ..of mouse CVD models that have become powerful tools for pre-clinical studies of factors contributing to coronary disease. However, dedicated imaging systems with high spatial and temporal resolution are required to image the mouse ..
  30. CMR-IMPACT
    CHADWICK DAVID MILLER; Fiscal Year: 2013
    ..As an alternative, cardiac magnetic resonance (CMR) imaging is highly accurate for detecting significant coronary disease and the need for coronary revascularization...
  31. EGR-1 Mediated Revascularization and Arteriogenic Bypass
    Todd K Rosengart; Fiscal Year: 2013
    ..S. alone, who can be expected to die annually from coronary disease, and approximately 100,000 individuals will suffer limb loss from peripheral vascular disease...
  32. Novel Imaging to Predict Cardiovascular Events in Diabetes
    Zahi A Fayad; Fiscal Year: 2010
    ..In order to accomplish these aims, we will recruit 380 diabetic patients with multi-vessel coronary disease from eleven greater New York metropolitan area hospitals...
  33. Troponin Elevation in Patients with Acute Coronary Syndrome & Decreased Kidney Fu
    Claudine T Jurkovitz; Fiscal Year: 2010
    ..versus conservative) and CKD stages, after adjusting for comorbidities, burden of disease, severity of coronary disease and insurance status...
  34. Survival and Age Biases in Gene Associations with Coronary Disease
    Jennifer R Dungan; Fiscal Year: 2010
    ..This research may help improve health outcomes and survival for people with heart disease. ..
  35. Novel Technologies to Identify Preclinical Coronary Disease in High Risk Families
    Lewis C Becker; Fiscal Year: 2010
    ..Our project is entitled "Novel Technologies to Identify Preclinical Coronary Disease in High Risk Families...
  36. Pharmacogenomics of Anti-platelet Response
    Rehan Qayyum; Fiscal Year: 2013
    ..important public health implications given the notable potential impact of effective anti-platelet therapy on coronary disease and stroke outcomes in high risk persons...
  37. Moving Beyond HDL Cholesterol, HDL Function as a Coronary Disease Biomarker
    ANAND KUMAR ROHATGI; Fiscal Year: 2013
    ..research skills allowing me to pursue broad epidemiologic assessments of novel biomarkers in improving coronary disease risk prediction in the Dallas Heart Study, culminating in several first-author publications and completion of ..
  38. Contrast-Enhanced Whole-Heart Coronary MRA at 3.0T
    Debiao Li; Fiscal Year: 2012
    ..The overall objective of the project is to develop new magnetic resonace imaging techniques to increase the diagnostic accuracy of coronary disease, to reduce costs of diagnosis, and to improve patient care.
  39. Gene Delivery Stents
    Robert J Levy; Fiscal Year: 2013
    ..SUMMARY Stent angioplasty over the last decade has made a major impact on improved therapeutic outcomes for coronary disease. Our group has pioneered the concept that an even greater therapeutic benefit than possible with current bare ..
  40. Sex Differences: Pathophysiology of Symptomatic Non-Obstructive Coronary Disease
    JENNIFER ANN TREMMEL; Fiscal Year: 2013
    ..End of Abstract) ..
  41. INHALATIONAL ANESTHETICS AND CORONARY VASOMOTION
    JOHN SILL; Fiscal Year: 1992
    ..Episodic changes in coronary tone occur in both variant and typical coronary disease. Endothelial damage may be responsible for increased sensitivity to endogenous vasconstrictor substances...
  42. RESCUE: Randomized Evaluation of Patients with Stable Angina Comparing Utilizatio
    Arthur E Stillman; Fiscal Year: 2010
    ..effectiveness of "aggressive medical management and percutaneous coronary interventions in treating stable coronary disease for patients of different ages and with different comorbidities...
  43. Efferocytosis in CVD &Inflammation
    EDWARD BENJAMIN THORP; Fiscal Year: 2013
    ..Interestingly, preliminary data also suggest that advanced coronary disease in humans coincides with proteolytic degradation of MERTK...
  44. mTOR Signaling and Vascular Repair in an Experimental Model of Diabetes Mellitus
    ALOKE VIRMANI FINN; Fiscal Year: 2013
    ..understanding of the cellular mechanisms required to inform treatment strategies in diabetic patients with coronary disease by delineating the cellular mechanisms by which mTOR inhibition delays endothelial regrowth, exploring the ..
  45. Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia
    A Eden Evins; Fiscal Year: 2010
    ..Mortality from coronary disease, pulmonary disease and cancer is 2-6 times higher in schizophrenia patients than age matched controls...
  46. HDL Heterogeneity and Function, Statin Therapy, and CVD Outcomes
    Samia Mora; Fiscal Year: 2013
    ..of chronic inflammation in the JUPITER trial, and another 10,001 secondary prevention patients with stable coronary disease in the TNT trial (total 784 CVD events)...
  47. Novel 99mTc(III) Complexes as SPECT Radiotracers for MPI
    Shuang Liu; Fiscal Year: 2013
    ..flow rate and the radiotracer myocardial uptake will permit better detection of the presence and extent of coronary disease, and more precise delineation of myocardial perfusion defects, which is of considerable benefit in management ..
  48. Heart Smart
    Patrice G Saab; Fiscal Year: 2010
    ..2) communicate the range of disorders associated with the risk factors, including obesity, diabetes, and coronary disease, and 3) communicate the critical importance of controlling cardiovascular risk through nutrition, activity ..
  49. Implementation of cardiopulmonary resuscitation training for at-risk families
    Benjamin S Abella; Fiscal Year: 2013
    ..Individuals with coronary disease are at significantly increased risk of SCA, and greater than 75% of SCA events occur in the home environment...
  50. Mitral Regurgitation, Heart Failure and Coronary Disease: Benefits to MV Repair?
    Robert Michler; Fiscal Year: 2012
    ..Follow up at 1, 3, 6, and 12 months for the first year and at 6 month intervals thereafter, will evaluate endpoints. A Clinical Research Skills Development Core submission will accompany this proposal. (End of Abstract) ..
  51. Coronary Vascular Cell Development
    Takashi Mikawa; Fiscal Year: 2013
    ..Limited options of effective treatments contribute to the continued prevalence of coronary disease. The proposed study will explore the molecular mechanisms that regulate the earliest developmental steps of ..
  52. Characterization of Atherosclerosis Modifier Genes
    Jonathan D Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atherosclerotic coronary disease is the most common cause of mortality in the United States...
  53. Mitral Regurgitation, Heart Failure and Coronary Disease: Benefits to MV Repair
    Robert Michler; Fiscal Year: 2013
    ..abstract_text> ..
  54. Improved Estimates of the Comparative Treatment Effects of CABG and PCI
    Mark A Hlatky; Fiscal Year: 2010
    ..The methods validated in this test case study of coronary disease will then be more general tools that may be applied broadly to evaluate other therapies and other patient ..
  55. DOES ATHEROSCLEROSIS REGRESS WITH THERAPY FOR LOW HDLC?
    Bruce Brown; Fiscal Year: 2000
    More than one-third of patients with coronary disease (CAD) have "low" HDL cholesterol (HDLc) levels (less than 35 mg/dl; U.S. 20th percentile) and "normal" LDLc (less than 145; U.S...
  56. Selectin targeted ultrasound contrast agents for detection of acute coronary synd
    Joshua J Rychak; Fiscal Year: 2013
    ..toxicology studies in two species, characterize the behavior of our imaging agent in mouse models of complex coronary disease, and validate imaging efficacy using clinical-scale imaging equipment in a closed- chest canine model...
  57. HIGH DENSITY LIPOPROTEIN SUBSPECIES AND CORONARY DISEASE
    Bela Asztalos; Fiscal Year: 2003
    ..The investigators state that these studies should provide better understanding about the diagnosis and treatment of HDL deficiency for the prevention of CHD. ..
  58. Magnetic Resonance Imaging Subsystem for Evaluation of Valvular Disease
    Juan M Santos; Fiscal Year: 2012
    ..by applicant): Valvular heart diseases are conventionally overshadowed by the very high prevalence of coronary disease. However, moderate to severe valvular heart disease is present in more than 12% of patients over the age of ..
  59. Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor
    Y Andrew Wang; Fiscal Year: 2013
    ..e., NanoK) approach for direct rapid assessment of coronary disease in the ED could help resolve this clinical dilemma...
  60. Cleveland Clinic Cardiothoracic Collaborative Clinical Center (C6)
    Bruce Lytle; Fiscal Year: 2013
    ..Percutaneous coronary intervention then replaced CABG as initial treatment of coronary disease;now percutaneous valve procedures threaten the specialty once again...
  61. 3D CORONARY RECONSTRUCTION AND MULTIMODALITY FUSION
    Shiuh Yung Chen; Fiscal Year: 2003
    ..Specifically, the spatial 3-D geometry of coronary arteries and the morphology of coronary disease will be generated from respective routine angiograms and IVUS cross-sectional images to facilitate diagnostic ..
  62. Early Noninvasive Detection of Myocardial Microbascular Dysfunction in Diabetes
    Angela M Taylor; Fiscal Year: 2013
    ..process thus tailoring therapy and reducing costs, to offer a safer diagnostic mechanism, and to treat coronary disease eariier preventing future events thus contributing to significant improvements in public health...
  63. EFFECTS OF CHD PREVENTION ON LIPOPROTEIN SUBCLASSES
    Paul Williams; Fiscal Year: 1993
    ..HDL2b is reduced relative to HDL3c and HDL3b Our objective is to assess the influence of HDL-subclasses with coronary disease progression, and to identify factors influencing HDL subclasses at baseline and over time...
  64. In Vivo Measurement of Myocardial Oxygen Consumption
    BRIGITTE PONCELET; Fiscal Year: 2004
    ..of the heart to convert oxygen into work is found in various forms of ventricular dysfunction unrelated to coronary disease (hypertrophy, cardiomyopathy)...
  65. Retinal Vascular Changes in Type 1 Diabetic African-Americans
    Monique Roy; Fiscal Year: 2007
    ..a potentially useful clinical prognosticator of progression of DR and incidence of CVD (hypertension, coronary disease, stroke, and lower extremity amputation)...
  66. ANXIETY & VAGAL CONTROL OF THE HEART IN CORONARY DISEASE
    Lana Watkins; Fiscal Year: 2002
    ..abstract_text> ..
  67. Flow-Mediated Dilation of Human Coronary Arterioles
    David D Gutterman; Fiscal Year: 2010
    ..our laboratory indicate that flow-mediated dilation (FMD) occurs in coronary arterioles from patients with coronary disease however it operates through a novel mechanism involving endothelial production of reactive oxygen species (..
  68. CHARACTERIZATION OF CORONARY PRONE PEDIGREES
    Roger Williams; Fiscal Year: 1990
    The goal of this study is to understand the genetics and epidemiology of different types of early familiar coronary disease to learn how to prevent or delay early myocardial infarction and death...