coronary disease

Summary

Summary: An imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Top Publications

  1. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  2. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
  3. ncbi Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  4. ncbi Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
    R B D'Agostino
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    JAMA 286:180-7. 2001
  5. ncbi Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    C Baigent
    Lancet 366:1267-78. 2005
  6. pmc Collaborative care for patients with depression and chronic illnesses
    Wayne J Katon
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    N Engl J Med 363:2611-20. 2010
  7. ncbi Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    N Engl J Med 354:1264-72. 2006
  8. ncbi HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
    Philip Barter
    Heart Research Institute, Sydney, Australia
    N Engl J Med 357:1301-10. 2007
  9. ncbi Effects of torcetrapib in patients at high risk for coronary events
    Philip J Barter
    Heart Research Institute, Camperdown, Sydney, NSW, Australia
    N Engl J Med 357:2109-22. 2007
  10. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009

Detail Information

Publications234 found, 100 shown here

  1. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  2. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  3. ncbi Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  4. ncbi Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
    R B D'Agostino
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    JAMA 286:180-7. 2001
    ..Concern exists regarding whether these functions can be generalized to other populations...
  5. ncbi Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    C Baigent
    Lancet 366:1267-78. 2005
    ..But each separate trial has limited power to assess particular outcomes or particular categories of participant...
  6. pmc Collaborative care for patients with depression and chronic illnesses
    Wayne J Katon
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    N Engl J Med 363:2611-20. 2010
    ..We conducted a study to determine whether coordinated care management of multiple conditions improves disease control in these patients...
  7. ncbi Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    N Engl J Med 354:1264-72. 2006
    ..We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population...
  8. ncbi HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
    Philip Barter
    Heart Research Institute, Sydney, Australia
    N Engl J Med 357:1301-10. 2007
    ..High-density lipoprotein (HDL) cholesterol levels are a strong inverse predictor of cardiovascular events. However, it is not clear whether this association is maintained at very low levels of low-density lipoprotein (LDL) cholesterol...
  9. ncbi Effects of torcetrapib in patients at high risk for coronary events
    Philip J Barter
    Heart Research Institute, Camperdown, Sydney, NSW, Australia
    N Engl J Med 357:2109-22. 2007
    ..We investigated whether torcetrapib, a potent CETP inhibitor, might reduce major cardiovascular events. The trial was terminated prematurely because of an increased risk of death and cardiac events in patients receiving torcetrapib...
  10. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
    ..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
  11. ncbi Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project
    R M Conroy
    Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Eur Heart J 24:987-1003. 2003
    ..The SCORE project was initiated to develop a risk scoring system for use in the clinical management of cardiovascular risk in European clinical practice...
  12. ncbi Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis
    Jurgen Barth
    Department of Rehabilitation Psychology, Institute of Psychology, University of Freiburg, Germany
    Psychosom Med 66:802-13. 2004
    ..The relative risk in meta-analytic aggregation is 1.64 (confidence interval [CI], 1.29-2.08) for any CHD event. However, the adverse impact of depression on CHD patients has not yet been the subject of a meta-analysis...
  13. pmc Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
    Mary A Whooley
    VA Medical Center, San Francisco, California, USA
    JAMA 300:2379-88. 2008
    ..Depressive symptoms predict adverse cardiovascular outcomes in patients with coronary heart disease, but the mechanisms responsible for this association are unknown...
  14. ncbi AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute
    Sidney C Smith
    Circulation 113:2363-72. 2006
  15. ncbi Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials
    Rod S Taylor
    Department of Epidemiology and Public Health, University of Birmingham, Birmingham, United Kingdom
    Am J Med 116:682-92. 2004
    ..To review the effectiveness of exercise-based cardiac rehabilitation in patients with coronary heart disease...
  16. ncbi Optimal medical therapy with or without PCI for stable coronary disease
    William E Boden
    Western New York Veterans Affairs Healthcare Network and Buffalo General Hospital SUNY, Buffalo, NY 14203, USA
    N Engl J Med 356:1503-16. 2007
    ....
  17. ncbi Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies
    Amanda Nicholson
    Department of Epidemiology and Public Health, University College London Medical School, 1 19 Torrington Place, London WC1E 6BT, UK
    Eur Heart J 27:2763-74. 2006
    ..We quantified the effect of depression on CHD, assessing the extent of confounding by coronary risk factors and disease severity...
  18. ncbi Work stress in the etiology of coronary heart disease--a meta-analysis
    Mika Kivimaki
    Finnish Insitute of Occupational Health, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    Scand J Work Environ Health 32:431-42. 2006
    ..This study focused on estimating the relative risk of coronary heart disease (CHD) in association with work stress, as indicated by the job-strain model, the effort-reward imbalance model, and the organizational injustice model...
  19. ncbi Adherence to a Mediterranean diet and survival in a Greek population
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    N Engl J Med 348:2599-608. 2003
    ..Adherence to a Mediterranean diet may improve longevity, but relevant data are limited...
  20. ncbi DS14: standard assessment of negative affectivity, social inhibition, and Type D personality
    Johan Denollet
    Medical Psychology, Department of Psychology and Health, Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands
    Psychosom Med 67:89-97. 2005
    ..This study reports on the Type D Scale-14 (DS14) as a standard measure of NA, SI, and Type D...
  21. doi Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:2518-28. 2009
    ..The genetic determinants of the Lp(a) lipoprotein level and their relevance for the risk of coronary disease are incompletely understood.
  22. doi Adolescent BMI trajectory and risk of diabetes versus coronary disease
    Amir Tirosh
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 364:1315-25. 2011
    ..The association of body-mass index (BMI) from adolescence to adulthood with obesity-related diseases in young adults has not been completely delineated...
  23. ncbi Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 344:1959-65. 2001
    ..We hypothesized that statins might prevent coronary events in persons with elevated C-reactive protein levels who did not have overt hyperlipidemia...
  24. pmc Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies
    Alexander Thompson
    Lp PLA2 Studies Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:1536-44. 2010
    ..We investigated associations of circulating Lp-PLA(2) mass and activity with risk of coronary heart disease, stroke, and mortality under different circumstances...
  25. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  26. ncbi Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    Shaista Malik
    Heart Disease Prevention Program, University of California, Irvine 92697, USA
    Circulation 110:1245-50. 2004
    ..We examined the impact of MetS on CHD, CVD, and overall mortality among US adults...
  27. pmc Socioeconomic position, co-occurrence of behavior-related risk factors, and coronary heart disease: the Finnish Public Sector study
    Mika Kivimaki
    Department of Epidemiology and Public Health, University College London, London, UK
    Am J Public Health 97:874-9. 2007
    ..We examined the associations between socioeconomic position, co-occurrence of behavior-related risk factors, and the effect of these factors on the relative and absolute socioeconomic gradients in coronary heart disease...
  28. doi EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries
    Kornelia Kotseva
    Department of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Eur J Cardiovasc Prev Rehabil 16:121-37. 2009
    ....
  29. pmc Contribution of modern cardiovascular treatment and risk factor changes to the decline in coronary heart disease mortality in Scotland between 1975 and 1994
    S Capewell
    University of Glasgow, Department of Public Health, 2 Lilybank Gardens, Glasgow G12 8RZ, UK
    Heart 81:380-6. 1999
    ..To estimate the fall in coronary heart disease (CHD) mortality in Scotland attributable to medical and surgical treatments, and risk factor changes, between 1975 and 1994...
  30. pmc Coronary artery calcium score and risk classification for coronary heart disease prediction
    Tamar S Polonsky
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 303:1610-6. 2010
    ..The coronary artery calcium score (CACS) has been shown to predict future coronary heart disease (CHD) events. However, the extent to which adding CACS to traditional CHD risk factors improves classification of risk is unclear...
  31. pmc A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses
    Samuli Ripatti
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland mm fi
    Lancet 376:1393-400. 2010
    ..We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design...
  32. ncbi Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
    ..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis...
  33. ncbi Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 112:2627-33. 2005
    ..Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate within the normal range may also be associated with adverse outcomes...
  34. ncbi Job strain and major risk factors for coronary heart disease among employed males and females in a Swedish study on work, lipids and fibrinogen
    Lars Alfredsson
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Work Environ Health 28:238-48. 2002
    ..The aim of this study was to analyze the relationship of job strain (high psychological job demands and low decision latitude) to hypertension, serum lipids, and plasmafibrinogen...
  35. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  36. ncbi Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review
    Lawson R Wulsin
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Psychosom Med 65:201-10. 2003
    The objectives of this study were to systematically review the recent studies of the contribution of depression to the onset of coronary disease and to estimate the magnitude of the risk posed by depression for onset of coronary disease.
  37. ncbi Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies
    Ka He
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1102, Chicago, Ill 60611, USA
    Circulation 109:2705-11. 2004
    ..Results from observational studies on fish consumption and coronary heart disease (CHD) mortality are inconsistent...
  38. ncbi Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms
    Robert M Carney
    Department of Psychiatry, Suite 420, Behavioral Medicine Center, Washington University School of Medicine, 4625 Lindell Boulevard, St Louis, MO 63108, USA
    J Psychosom Res 53:897-902. 2002
    ..behavioral and physiological mechanisms that might explain how depression increases the risk for incident coronary disease and for subsequent cardiac morbidity and mortality. The candidate mechanisms include: (1)...
  39. ncbi Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
    ..We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD)...
  40. doi Best-practice interventions to reduce socioeconomic inequalities of coronary heart disease mortality in UK: a prospective occupational cohort study
    Mika Kivimaki
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 372:1648-54. 2008
    ..We assessed this issue in an occupational cohort study comparing low with high socioeconomic groups...
  41. doi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
    ..However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups...
  42. pmc Association of glycemic index and glycemic load with risk of incident coronary heart disease among Whites and African Americans with and without type 2 diabetes: the Atherosclerosis Risk in Communities study
    Dale S Hardy
    Division of Epidemiology, University of Texas School of Public Health, Houston, TX 77225, USA
    Ann Epidemiol 20:610-6. 2010
    ..In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes...
  43. doi Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
    Bernard De Bruyne
    Cardiovascular Center Aalst, Onze Lieve Vrouw Clinic, Aalst, Belgium
    N Engl J Med 367:991-1001. 2012
    ....
  44. pmc Dietary glycemic load and glycemic index and risk of coronary heart disease and stroke in Dutch men and women: the EPIC-MORGEN study
    Koert N J Burger
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 6:e25955. 2011
    ..The associations of glycemic load (GL) and glycemic index (GI) with the risk of cardiovascular diseases (CVD) are not well-established, particularly in men, and may be modified by gender...
  45. ncbi The use of fractional polynomials to model continuous risk variables in epidemiology
    P Royston
    Department of Medical Statistics and Evaluation, Imperial College School of Medicine, London, UK
    Int J Epidemiol 28:964-74. 1999
    ..The traditional method of analysing continuous or ordinal risk factors by categorization or linear models may be improved...
  46. ncbi Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Circulation 112:3375-83. 2005
    ....
  47. ncbi A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women
    S Liu
    Departments of Epidemiology and Nutrition, The Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 71:1455-61. 2000
    ..Little is known about the effects of the amount and type of carbohydrates on risk of coronary heart disease (CHD)...
  48. ncbi Explaining the decrease in U.S. deaths from coronary disease, 1980-2000
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 356:2388-98. 2007
    ..We conducted a study to determine how much of this decrease could be explained by the use of medical and surgical treatments as opposed to changes in cardiovascular risk factors...
  49. ncbi C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    John Danesh
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 350:1387-97. 2004
    ..We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease...
  50. doi Dietary glycemic load and index and risk of coronary heart disease in a large italian cohort: the EPICOR study
    Sabina Sieri
    Nutritional Epidemiology Unit, Fondazione IRCCS Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy
    Arch Intern Med 170:640-7. 2010
    ....
  51. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  52. ncbi Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
    ..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain...
  53. doi Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study
    Robert N Foley
    United States Renal Data System, Minneapolis, MN 55404, USA
    Am Heart J 156:556-63. 2008
    ..Calcium-phosphate levels, linked to vascular dysfunction in chronic kidney disease, may represent novel risk factors for coronary heart disease, stroke, and death in community-dwelling adults...
  54. ncbi Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    N Engl J Med 348:109-18. 2003
    ..Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear...
  55. doi Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 303:1841-7. 2010
    ..Coronary heart disease (CHD) mortality has declined substantially in Canada since 1994...
  56. pmc Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study
    Marianna Virtanen
    Finnish Institute of Occupational Health, Centre of Expertise for Work Organizations, Topeliuksenkatu 41 aA, FIN 00250 Helsinki, Finland
    Eur Heart J 31:1737-44. 2010
    ..To examine the association between overtime work and incident coronary heart disease (CHD) among middle-aged employees...
  57. pmc Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies
    Rachel Huxley
    George Institute for International Health, University of Sydney, PO Box M201, Sydney, NSW 2050, Australia
    BMJ 332:73-8. 2006
    ..To estimate the relative risk for fatal coronary heart disease associated with diabetes in men and women...
  58. ncbi Perceived job stress and incidence of coronary events: 3-year follow-up of the Belgian Job Stress Project cohort
    Dirk De Bacquer
    Department of Public Health, Ghent University, Ghent, Belgium
    Am J Epidemiol 161:434-41. 2005
    ..However, our study underscores the importance of a supportive social work environment in the prevention of coronary heart disease...
  59. ncbi n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Am J Clin Nutr 77:319-25. 2003
    ....
  60. pmc Explaining the decrease in coronary heart disease mortality in Italy between 1980 and 2000
    Luigi Palmieri
    National Centre of Epidemiology, Surveillance, and Promotion of Health, National Institutes of Health, 00162 Rome, Italy
    Am J Public Health 100:684-92. 2010
    ..We examined the extent to which the decrease in coronary heart disease (CHD) mortality rates in Italy could be explained by changes in cardiovascular risk factors versus the use of medical and surgical treatments...
  61. doi Effect of PCI on quality of life in patients with stable coronary disease
    William S Weintraub
    Christiana Care Health System, Newark, DE 19718, USA
    N Engl J Med 359:677-87. 2008
    ..It has not been clearly established whether percutaneous coronary intervention (PCI) can provide an incremental benefit in quality of life over that provided by optimal medical therapy among patients with chronic coronary artery disease...
  62. doi Independent association of HbA(1c) and incident cardiovascular disease in people without diabetes
    Robert J Adams
    University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville, South Australia, Australia
    Obesity (Silver Spring) 17:559-63. 2009
    ..Unlike previous studies, this relationship was not substantially attenuated by other traditional risk factors...
  63. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  64. ncbi Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study
    M De Lorgeril
    Explorations Fonctionnelles Cardiorespiratoires et Métaboliques, CHU de Saint Etienne, France
    Circulation 99:779-85. 1999
    ..This report presents results of an extended follow-up (with a mean of 46 months per patient) and deals with the relationships of dietary patterns and traditional risk factors with recurrence...
  65. ncbi Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils o
    Gary J Balady
    Boston University Medical Center, USA
    Circulation 115:2675-82. 2007
    ....
  66. doi HDL biogenesis and functions: role of HDL quality and quantity in atherosclerosis
    Eirini M Tsompanidi
    University of Patras Medical School, Department of Medicine, Pharmacology Unit, Rio, TK, Greece
    Atherosclerosis 208:3-9. 2010
    ..In addition, we discuss the significance of both HDL quality and quantity in assessing cardiovascular risk...
  67. doi Contribution of high plasma triglycerides and low high-density lipoprotein cholesterol to residual risk of coronary heart disease after establishment of low-density lipoprotein cholesterol control
    Vincent J Carey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 106:757-63. 2010
    ..Thus, high TGs might have greater importance in patients with optimal rather than greater LDL cholesterol concentrations...
  68. ncbi Fetal origins of adult disease: strength of effects and biological basis
    D J P Barker
    Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
    Int J Epidemiol 31:1235-9. 2002
    ....
  69. doi Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study
    Olga A Iakoubova
    Celera, Alameda, California 9450, USA
    J Am Coll Cardiol 51:449-55. 2008
    ..We explored whether the benefit of intensive versus moderate statin therapy would be greater in carriers of KIF6 719Arg than in noncarriers...
  70. doi Modelling the decreasing coronary heart disease mortality in Sweden between 1986 and 2002
    Lena Björck
    Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Eur Heart J 30:1046-56. 2009
    ....
  71. doi A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study
    Dov Shiffman
    Celera, Alameda, California 94502, USA
    J Am Coll Cardiol 51:444-8. 2008
    ..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women...
  72. ncbi Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    Mitsuhiro Yokoyama
    Kobe University, Kobe, Japan
    Lancet 369:1090-8. 2007
    ..We aimed to test the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who consume a large amount of fish...
  73. doi Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials
    Olga A Iakoubova
    Celera, Inc, Alameda, California 94502, USA
    J Am Coll Cardiol 51:435-43. 2008
    ....
  74. ncbi The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis
    Amol Ashok Bahekar
    Department of Cardiology, Chicago Medical School North Chicago Veterans Affairs Medical Center, Chicago, IL 60064, USA
    Am Heart J 154:830-7. 2007
    ..Previous studies have shown conflicting results as to whether periodontitis (PD) is associated with increased risk of coronary heart disease (CHD). The aim of the current study was to evaluate whether such an association exists...
  75. ncbi Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials
    J C LaRosa
    Office of the President, State University of New York Health Science Center at Brooklyn, 11203, USA
    JAMA 282:2340-6. 1999
    ..Lowering low-density lipoprotein cholesterol (LDL-C) is known to reduce risk of recurrent coronary heart disease in middle-aged men. However, this effect has been uncertain in elderly people and women...
  76. doi Extended-release niacin or ezetimibe and carotid intima-media thickness
    Allen J Taylor
    Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA
    N Engl J Med 361:2113-22. 2009
    ....
  77. ncbi Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 48:298-304. 2006
    ..This study sought to assess the influence of type 2 diabetes mellitus (T2DM) and the impact of hypoglycemic treatment (insulin vs. noninsulin) on platelet function profiles in patients treated with dual oral antiplatelet therapy...
  78. pmc Randomized controlled trial of an informatics-based intervention to increase statin prescription for secondary prevention of coronary disease
    William T Lester
    Laboratory of Computer Science, Massachusetts General Hospital, and Harvard Medical School, Boston, Mass, USA
    J Gen Intern Med 21:22-9. 2006
    ..Suboptimal treatment of hyperlipidemia in patients with coronary artery disease (CAD) is well documented. We report the impact of a computer-assisted physician-directed intervention to improve secondary prevention of hyperlipidemia...
  79. ncbi White cell telomere length and risk of premature myocardial infarction
    Scott Brouilette
    Division of Cardiology, Department of Medicine, University of Leicester, United Kingdom
    Arterioscler Thromb Vasc Biol 23:842-6. 2003
    ..Mean telomeres lengths provide an assessment of biological age with shorter telomeres, indicating increased biological age. We investigated whether subjects with premature myocardial infarction (MI) had shorter leukocyte telomeres...
  80. ncbi Depression as a predictor for coronary heart disease. a review and meta-analysis
    Reiner Rugulies
    Division of Occupational and Environmental Medicine, University of California, San Francisco, USA
    Am J Prev Med 23:51-61. 2002
    ..To review and quantify the impact of depression on the development of coronary heart disease (CHD) in initially healthy subjects...
  81. ncbi Fetal programming of coronary heart disease
    David J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:364-8. 2002
    ..Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth...
  82. pmc Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Arterioscler Thromb Vasc Biol 28:173-9. 2008
    ....
  83. pmc Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000252. 2010
    ..Additionally, some public health groups recommend lowering or limiting polyunsaturated fat (PUFA) consumption, a major potential replacement for SFA...
  84. doi Changes in residential proximity to road traffic and the risk of death from coronary heart disease
    Wen Qi Gan
    School of Environmental Health, The University of British Columbia, Vancouver, BC, Canada
    Epidemiology 21:642-9. 2010
    ..Residential proximity to road traffic is associated with increased coronary heart disease (CHD) morbidity and mortality. It is unknown, however, whether changes in residential proximity to traffic could alter the risk of CHD mortality...
  85. ncbi Five common gene variants identify elevated genetic risk for coronary heart disease
    Lance A Bare
    Celera, Alameda, California 94502, USA
    Genet Med 9:682-9. 2007
    ....
  86. pmc Including socioeconomic status in coronary heart disease risk estimation
    Peter Franks
    Center for Healthcare Policy and Research, Sacramento, California, USA
    Ann Fam Med 8:447-53. 2010
    ..We examined whether hybrid SES measures (based on area measures of income and individual education) address this bias and derived an approach to incorporating SES information into treatment guidelines...
  87. doi Coronary calcium score improves classification of coronary heart disease risk in the elderly: the Rotterdam study
    Suzette E Elias-Smale
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 56:1407-14. 2010
    ....
  88. pmc Benefits of statin therapy and compliance in high risk cardiovascular patients
    Joel A Lardizabal
    Division of Cardiology, Department of Medicine, University of California in San Francisco Fresno MEP, Fresno, CA, USA
    Vasc Health Risk Manag 6:843-53. 2010
    ..To fully reap the benefits of statin therapy, interventions which improve long-term treatment compliance in real-world settings should be encouraged...
  89. pmc Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk ≥ 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 32:75-83. 2011
    ..However, as these are post hoc analyses, data describing these subgroups have not previously been available to the clinical community...
  90. ncbi Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study
    Hok Hay S Oei
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 111:570-5. 2005
    ..In the present study, we investigated whether Lp-PLA2 is an independent predictor of coronary heart disease and ischemic stroke...
  91. pmc Integrating depression and chronic disease care among patients with diabetes and/or coronary heart disease: the design of the TEAMcare study
    Wayne Katon
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, United States
    Contemp Clin Trials 31:312-22. 2010
    ..This intervention is being tested in an NIMH-funded randomized controlled trial in a large integrated health plan...
  92. pmc Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary disease
    Han W Kim
    Duke Cardiovascular Magnetic Resonance Center, Division of Cardiology, Duke University, Durham, North Carolina, USA
    PLoS Med 6:e1000057. 2009
    ..The aim of this study was to investigate the prevalence and prognosis associated with non-Q-wave UMI identified by DE-CMR...
  93. pmc Does the routine use of global coronary heart disease risk scores translate into clinical benefits or harms? A systematic review of the literature
    Stacey L Sheridan
    Division of General Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Health Serv Res 8:60. 2008
    ..Guidelines now recommend routine assessment of global coronary heart disease (CHD) risk scores. We performed a systematic review to assess whether global CHD risk scores result in clinical benefits or harms...
  94. ncbi Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Germany
    Circulation 105:310-5. 2002
    ..Although several scoring schemes have been suggested to calculate this profile, many omit information on important variables such as family history of coronary heart disease or LDL cholesterol...
  95. ncbi Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study
    Lloyd E Chambless
    Department of Biostatistics, University of North Carolina, CB 8300, 137 East Franklin Street, Suite 400, Bank of America Center, Chapel Hill, NC 27514 4145, USA
    J Clin Epidemiol 56:880-90. 2003
    ..These factors substantially improved prediction of future CHD for men, less for women, and also increased attributable risks...
  96. pmc Prospective analysis of traffic exposure as a risk factor for incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study
    Haidong Kan
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 116:1463-8. 2008
    ..For people living close to busy roads, traffic is a major source of air pollution. Few prospective data have been published on the effects of long-term exposure to traffic on the incidence of coronary heart disease (CHD)...
  97. doi Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 30:2742-8. 2009
    ..We sought to evaluate whether systemic sPLA(2) is associated with prognosis in patients with coronary heart disease (CHD)...
  98. pmc Prediction of coronary heart disease risk in a general, pre-diabetic, and diabetic population during 10 years of follow-up: accuracy of the Framingham, SCORE, and UKPDS risk functions: The Hoorn Study
    Amber A W A van der Heijden
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 32:2094-8. 2009
    ....
  99. ncbi Reviewing myocardial silent ischemia: specific patient subgroups
    Theodoros Xanthos
    Department of Experimental Surgery and Surgical Research N S Christeas, Athens School of Medicine, Athens, Greece
    Int J Cardiol 124:139-48. 2008
    ....
  100. doi Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healt
    Benoit J Arsenault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Quebec, Canada
    J Am Coll Cardiol 55:35-41. 2009
    ....
  101. doi Patient-reported health status in coronary heart disease in the United States: age, sex, racial, and ethnic differences
    Jipan Xie
    Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop K 47, 4770 Buford Hwy NE, Atlanta, GA 30341 3717, USA
    Circulation 118:491-7. 2008
    ..Coronary heart disease (CHD) affects 15.8 million Americans. However, data on the national impact of CHD on health-related quality of life, particularly among people of different age, sex, racial, and ethnic groups, are limited...

Research Grants83

  1. The Coronary Screening for Kidney Transplantation (COST) Study
    Bertram Kasiske; Fiscal Year: 2007
    ..Candidates who are found to have significant coronary disease then undergo preemptive angioplasty or coronary artery bypass grafting to prevent posttransplant MACE...
  2. RESCUE: Randomized Evaluation of Patients with Stable Angina Comparing Utilizatio
    Arthur E Stillman; Fiscal Year: 2010
    ..effectiveness of "aggressive medical management and percutaneous coronary interventions in treating stable coronary disease for patients of different ages and with different comorbidities...
  3. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2010
    ..It will determine the importance of novel biomarkers to predict the risk of adverse events in clinical practice. ..
  4. HIGH DENSITY LIPOPROTEIN SUBSPECIES AND CORONARY DISEASE
    Bela Asztalos; Fiscal Year: 2003
    ..The investigators state that these studies should provide better understanding about the diagnosis and treatment of HDL deficiency for the prevention of CHD. ..
  5. NEUROLOGICAL AND COGNITIVE OUTCOMES FOLLOWING CABG
    GUY MC KHANN; Fiscal Year: 2003
    ..This procedure, although extraordinarily successful in relieving the symptoms of coronary disease, is also associated with a variety of neurologic problems, ranging from stroke to cognitive changes and ..
  6. 3D CORONARY RECONSTRUCTION AND MULTIMODALITY FUSION
    Shiuh Yung Chen; Fiscal Year: 2003
    ..Specifically, the spatial 3-D geometry of coronary arteries and the morphology of coronary disease will be generated from respective routine angiograms and IVUS cross-sectional images to facilitate diagnostic ..
  7. Cell Therapy for Improving Cardiac Function
    Douglas Vaughan; Fiscal Year: 2007
    ..A majority of patients with HF have poor left ventricular function, with 60-70% due to chronic ischemic coronary disease. The remainder of patients experience HF due to a variety of other causes, including idiopathic and viral ..
  8. Role of Hydrogen Peroxide in the Mechanism of Flow-Induced Dilation of the Human
    David D Gutterman; Fiscal Year: 2010
    ..Our recent data indicate that flow-mediated dilation (FMD) occurs in coronary arterioles from patients with coronary disease but operates through a novel mechanism involving endothelial production of reactive oxygen species (ROS) ..
  9. Transcriptional Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zippe
    Xing Ming Shi; Fiscal Year: 2010
    ..Since excess belly fat increases the risks of coronary disease and causes insulin resistance, both of which are major public health threats, understanding how PPAR(2 ..
  10. Transcriptional Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zippe
    Xingming Shi; Fiscal Year: 2009
    ..Since excess belly fat increases the risks of coronary disease and causes insulin resistance, both of which are major public health threats, understanding how PPAR(2 ..
  11. Transcriptional Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zippe
    Xing Ming Shi; Fiscal Year: 2010
    ..Since excess belly fat increases the risks of coronary disease and causes insulin resistance, both of which are major public health threats, understanding how PPAR(2 ..
  12. Mitral Regurgitation, Heart Failure and Coronary Disease: Benefits to MV Repair?
    Robert Michler; Fiscal Year: 2007
    ..Follow up at 1, 3, 6, and 12 months for the first year and at 6 month intervals thereafter, will evaluate endpoints. A Clinical Research Skills Development Core submission will accompany this proposal. (End of Abstract) ..
  13. In Vivo Measurement of Myocardial Oxygen Consumption
    BRIGITTE PONCELET; Fiscal Year: 2004
    ..of the heart to convert oxygen into work is found in various forms of ventricular dysfunction unrelated to coronary disease (hypertrophy, cardiomyopathy)...
  14. Retinal Vascular Changes in Type 1 Diabetic African-Americans
    Monique Roy; Fiscal Year: 2007
    ..a potentially useful clinical prognosticator of progression of DR and incidence of CVD (hypertension, coronary disease, stroke, and lower extremity amputation)...
  15. IVUS Detection of Rupture Prone Plaques
    Marvin M Doyley; Fiscal Year: 2009
    ..Coronary angiography, the "gold standard" employed to assess the severity of coronary disease in symptomatic patients, reveals only the degree of luminal narrowing, and fails to visualize the arterial ..
  16. ANXIETY & VAGAL CONTROL OF THE HEART IN CORONARY DISEASE
    Lana Watkins; Fiscal Year: 2002
    ..abstract_text> ..
  17. Flow-Mediated Dilation of Human Coronary Arterioles
    David Gutterman; Fiscal Year: 2007
    ..our laboratory indicate that flow-mediated dilation (FMD) occurs in coronary arterioles from patients with coronary disease however it operates through a novel mechanism involving endothelial production of reactive oxygen species (..
  18. Flow-Mediated Dilation of Human Coronary Arterioles
    David D Gutterman; Fiscal Year: 2010
    ..our laboratory indicate that flow-mediated dilation (FMD) occurs in coronary arterioles from patients with coronary disease however it operates through a novel mechanism involving endothelial production of reactive oxygen species (..
  19. Flow-Mediated Dilation of Human Coronary Arterioles
    David Gutterman; Fiscal Year: 2009
    ..our laboratory indicate that flow-mediated dilation (FMD) occurs in coronary arterioles from patients with coronary disease however it operates through a novel mechanism involving endothelial production of reactive oxygen species (..