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| myocardial ischemiaSummarySummary: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERIOSCLEROSIS), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). Top Publications
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Exosome secreted by MSC reduces myocardial ischemia/reperfusion injuryRuenn Chai Lai
Institute of Medical Biology, ASTAR, 138648 Singapore
Stem Cell Res 4:214-22. 2010..mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm...
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathyArman T Askari
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Lancet 362:697-703. 2003....- Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioningPeter Ferdinandy
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
Pharmacol Rev 59:418-58. 2007.... - Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylationFeng Gao
Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Circulation 105:1497-502. 2002..that phosphorylation of eNOS by insulin may participate in the cardioprotective effect of insulin after myocardial ischemia and reperfusion... - Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD studyFrans J Th Wackers
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Diabetes Care 27:1954-61. 2004To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines. - Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological processA L Moens
Department of Cardiology, University of Antwerp, Belgium
Int J Cardiol 100:179-90. 2005..g. tetrahydrobiopterin). One of such agents could be folic acid. In this review article the authors give an overview of the recent insights concerning pathogenesis and therapeutic possibilities to prevent IR-induced injury... - Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trialJan van Ramshorst
Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
JAMA 301:1997-2004. 2009Previous studies have suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular (LV) function in patients with chronic myocardial ischemia. - Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance studyHassan Abdel-Aty
Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
J Am Coll Cardiol 53:1194-201. 2009This study was designed to determine whether imaging myocardial edema would identify acute myocardial ischemia before irreversible injury takes place. - Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in ratsJeng Feng Lin
Department of Cardiology, Buddhist Tzu Chi Hospital, Taipei branch and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
Life Sci 83:313-7. 2008..Its cardioprotective effects may be due to a reduction of atrial natriuretic peptide and transforming growth factor-beta1, which are known to protect the heart from detrimental remodeling... 
Complementary prognostic values of stress myocardial perfusion and late gadolinium enhancement imaging by cardiac magnetic resonance in patients with known or suspected coronary artery diseaseKevin Steel
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Circulation 120:1390-400. 2009..We therefore tested the hypothesis that characterization of these 2 processes from coronary artery disease by CMR can provide complementary prognostic values...- Silent myocardial ischemiaPeter F Cohn
State University of New York Health Sciences Center, Stony Brook, NY 11794-8171, USA
Circulation 108:1263-77. 2003 - Myocardial ischemia and reperfusion injuryL Maximilian Buja
Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Cardiovasc Pathol 14:170-5. 2005..b>Myocardial ischemia results in a characteristic pattern of metabolic and ultrastructural changes that lead to irreversible .. - Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activityMasaaki Ii
Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
Circulation 111:1114-20. 2005..The possibility that EPCs could act as reservoirs of cytokines has been implied by several observations; however, a specific role for cytokine delivery has not been identified... - Preconditioning the diabetic heart: the importance of Akt phosphorylationAndrew Tsang
The Hatter Institute and Centre for Cardiology, University College London Hospitals, Grafton Way, London, WC1E 6DB, UK
Diabetes 54:2360-4. 2005..To protect the diabetic myocardium, it appears necessary to increase the IPC stimulus to achieve the threshold for cardioprotection and a critical level of Akt phosphorylation to mediate myocardial protection... - Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemiaS Fuchs
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
J Am Coll Cardiol 37:1726-32. 2001..We also defined, in vitro, whether bone marrow (BM) cells secrete vascular endothelial growth factor (VEGF) and macrophage chemoattractant protein-1 (MCP-1)... - Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: report of a caseShigeru Miyagawa
Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
Surg Today 39:133-6. 2009..After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis... - Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathwayRajesh G Katare
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan
J Mol Cell Cardiol 46:405-12. 2009..the mechanism behind the protection induced by intermittent fasting in a rat model of established chronic myocardial ischemia (MI). Chronic MI was induced in rats by occlusion of the left coronary artery... - Myocardial viability and survival in ischemic left ventricular dysfunctionRobert O Bonow
Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N Michigan Ave, Suite 1006, Chicago, IL 60611, USA
N Engl J Med 364:1617-25. 2011..However, the efficacy of this approach is uncertain... - Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitroShu yan Han
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, PR China
Phytomedicine 16:694-702. 2009..In this study, we investigated the anti-myocardial ischemia effects of a purified extract of C. tinctorius (ECT) both in vivo and in vitro... - Homocysteine and cardiovascular disease: evidence on causality from a meta-analysisDavid S Wald
Department of Cardiology, Southampton General Hospital, Southampton SO16 6YD
BMJ 325:1202. 2002.... - Clinical, imaging, and pathological characteristics of left ventricular thrombus: a comparison of contrast-enhanced magnetic resonance imaging, transthoracic echocardiography, and transesophageal echocardiography with surgical or pathological validationMonvadi B Srichai
Center for Integrated Non-Invasive Cardiovascular Imaging of Department of Radiology (Section of Cardiovascular Imaging, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am Heart J 152:75-84. 2006..Contrast-enhanced MRI provided the highest sensitivity and specificity for LV thrombus when compared to TTE and TEE, and should be considered in the care of patients at high risk of LV thrombus formation... - Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of "remote preconditioning"A Takaoka
First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
J Am Coll Cardiol 33:556-64. 1999This study examined the changes in myocardial energy metabolism during myocardial ischemia after "remote preconditioning" and investigated the involvement of adenosine receptors in the mechanisms of this effect. - Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damageAndrew Webb
Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, England
Proc Natl Acad Sci U S A 101:13683-8. 2004Nitric oxide (NO.) is thought to protect against the damaging effects of myocardial ischemia-reperfusion injury, whereas xanthine oxidoreductase (XOR) normally causes damage through the generation of reactive oxygen species... - Protective ischaemia in patients: preconditioning and postconditioningAsger Granfeldt
Department of Anesthesiology and Critical Care, Aarhus University, Aarhus, Denmark
Cardiovasc Res 83:234-46. 2009..This review will summarize the physiological preclinical data on preconditioning and Postcon that are relevant to their translation to clinical therapeutics and treatment... - Effect of dietary omega-3 fatty acids on the heart rate and the heart rate variability responses to myocardial ischemia or submaximal exerciseGeorge E Billman
Dept of Physiology and Cell Biology, Ohio State Univ, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, USA
Am J Physiol Heart Circ Physiol 300:H2288-99. 2011..g., exercise or acute myocardial ischemia), particularly in postmyocardial infarction (MI) patients, are unknown... - Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell deliveryJohn Terrovitis
The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Am Coll Cardiol 54:1619-26. 2009..The aim of this study was to quantify acute myocardial retention of cardiac-derived stem cells (CDCs) and evaluate different delivery methods with positron emission tomography (PET)... - Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudyLeslee J Shaw
Emory University School of Medicine, Atlanta, GA 30306, USA
Circulation 117:1283-91. 2008Extent and severity of myocardial ischemia are determinants of risk for patients with coronary artery disease, and ischemia reduction is an important therapeutic goal... - Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusionScott J Cameron
Department of Pharmacology/Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
FEBS Lett 566:255-60. 2004..We propose a novel role for BMK1 in protecting the heart from ischemia/reperfusion-induced cardiac injury... - Osteoprotegerin: a novel independent marker for silent myocardial ischemia in asymptomatic diabetic patientsAntoine Avignon
CHU Montpellier, Metabolic Diseases Department, Lapeyronie Hospital, Montpellier, France
Diabetes Care 30:2934-9. 2007We sought to evaluate osteoprotegerin, an inhibitor of osteoclastogenesis involved in atherosclerosis, and other novel risk factors as predictive markers of silent myocardial ischemia (SMI). - Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failureHabib M Razavi
Victoria Research Laboratories, 6th Floor, Lawson Health Research Institute, London Health Sciences Centre, Department of Medicine, University of Western Ontario, 800 Commissioners Road, London, Ontario, Canada N6A 4G5
Pharmacol Ther 106:147-62. 2005..by nitric oxide (NO) and to discuss the potential role that NO plays in cardiomyocyte apoptosis during myocardial ischemia/reperfusion and development of heart failure... - Comparison of different adult stem cell types for treatment of myocardial ischemiaKoen E A van der Bogt
Laboratory of Cardiothoracic Transplantation, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Circulation 118:S121-9. 2008..This study is designed to evaluate the therapeutic efficacy of 4 cell types in a murine model of myocardial infarction... - Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66(Shc) and monoamine oxidaseFabio Di Lisa
Department of Biomedical Sciences, University of Padova, Padova, Italy
Basic Res Cardiol 104:131-9. 2009..Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis... - Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in ratsS Senthil
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu 608 002, India
Toxicol Pathol 35:418-23. 2007..was designed to investigate the protective effect of oleanolic acid (OA) against isoproterenol-induced myocardial ischemia in rat myocardium. Wistar strain rats were pretreated with OA (20, 40, and 60 mg/kg, s... - Switch from caspase-dependent to caspase-independent death during heart development: essential role of endonuclease G in ischemia-induced DNA processing of differentiated cardiomyocytesNúria Bahi
Laboratori d Investigacio, Hospital Arnau de Vilanova, Department of Ciències Mèdiques Bàsiques, Universitat de Lleida, Av Rovira Roure, 80 25198 Lleida, Spain
J Biol Chem 281:22943-52. 2006.... - Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studiesChristof Stamm
Department of Cardiac Surgery, University of Rostock, Rostock, Germany
J Thorac Cardiovasc Surg 133:717-25. 2007..We then tested the hypothesis that CABG plus CD133+ cell injection would result in better contractile function than CABG alone... - Mechanisms of sudden cardiac deathMichael Rubart
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5225, USA
J Clin Invest 115:2305-15. 2005..Here, we review the role of aberrant intracellular Ca handling, ionic imbalances associated with acute myocardial ischemia, neurohumoral changes, and genetic predisposition in the pathogenesis of SCD due to cardiac arrhythmia... - The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the ratA Sivarajah
Centre for Experimental Medicine, Nephrology and Critical Care, The William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary-University of London, Charterhouse Square, London, UK
Shock 26:154-61. 2006We investigated whether (endogenous) hydrogen sulfide (H2S) protects the heart against myocardial ischemia and reperfusion injury... - Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanismsRei Shibata
Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
Nat Med 11:1096-103. 2005..These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms... - Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondriaQun Chen
Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
Am J Physiol Cell Physiol 294:C460-6. 2008..Thus ischemic damage to the ETC increased both the capacity and the net production of H(2)O(2) from complex I and complex III and sets the stage for an increase in ROS production during reperfusion as a mechanism of cardiac injury... - Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of researchR Bolli
Division of Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
J Mol Cell Cardiol 33:1897-918. 2001Over the past decade, an enormous number of studies (>100) have focused on the role of nitric oxide (NO) in myocardial ischemia. It is important to distinguish the function of NO in unstressed (non-preconditioned) myocardium from its .. - Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytesAnne Hamacher-Brady
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 281:29776-87. 2006.... - Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axisXiaofeng Hu
Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40202, USA
Circulation 116:654-63. 2007..However, the role of the SDF-1alpha-CXCR4 axis in modulating myocardial ischemia/reperfusion injury is unknown. - Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemiaRichard S Goldstein
Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ, Manhasset, NY 11030, USA
Shock 25:571-4. 2006Cerebral and myocardial ischemia, two of the leading causes of morbidity and mortality worldwide, are associated with inflammation that can lead to multiple organ failure and death... - MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotectionYanjie Lu
Department of Pharmacology, Harbin Medical University, Harbin, Heilongjiang 150081, People s Republic of China
Cardiovasc Res 84:434-41. 2009..The present study was designed to investigate whether the beneficial effects of beta-blocker propranolol are related to regulation of microRNA miR-1... - Mitral gradients and frequency of recurrence of mitral regurgitation after ring annuloplasty for ischemic mitral regurgitationMatthew L Williams
Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina, USA
Ann Thorac Surg 88:1197-201. 2009..We hypothesized that surgical revascularization and annuloplasty lead to a durable repair, but may also lead to increased mitral gradients that could limit the benefit of the repair technique... - Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometryYonghai Lv
Department of Medicinal Chemistry of Nature Product, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
J Pharm Biomed Anal 52:129-35. 2010b>Myocardial ischemia (MI) is a worldwide epidemic. Compound Danshen Tablets (CDTs), an herbal compound preparation, are widely used to treat MI in China... - Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35Marc S Sabatine
TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Eur Heart J 30:162-9. 2009..To determine whether an ultrasensitive assay can permit quantification of changes in circulating cardiac troponin (Tn) in the setting of stress test-induced myocardial ischaemia... - Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac functionA A Kocher
Department of Surgery, Columbia University, New York, New York, USA
Nat Med 7:430-6. 2001.... - Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cellsK A Jackson
Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
J Clin Invest 107:1395-402. 2001..3%, primarily in small vessels adjacent to the infarct. Our results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction... - Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in ratsXiaorong Hu
Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, China
Eur J Pharmacol 638:84-9. 2010Minocycline has been shown to protect against myocardial ischemia and reperfusion injury. However, the mechanism remains unclear... - CMR for characterization of the myocardium in acute coronary syndromesErica Dall'Armellina
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
Nat Rev Cardiol 7:624-36. 2010.... - Restrictive annuloplasty for ischemic mitral regurgitation may induce functional mitral stenosisJulien Magne
Laval Hospital Research Center Quebec Heart Institute, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
J Am Coll Cardiol 51:1692-701. 2008..The purpose of this study was to evaluate mitral valve hemodynamic performance and functional capacity in patients with ischemic mitral regurgitation (MR) who underwent restrictive mitral valve annuloplasty (MVA)... - Ambient fine particulate matter exposure and myocardial ischemia in the Environmental Epidemiology of Arrhythmogenesis in the Women's Health Initiative (EEAWHI) studyZhu Ming Zhang
Epidemiologic Cardiology Research Center, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27104, USA
Environ Health Perspect 117:751-6. 2009..Ambient particulate matter (PM) air pollution is associated with coronary heart disease, but the pathways underlying the association remain to be elucidated... - Myocardial ischemia, carotid, and peripheral arterial disease and their interrelationship in type 2 diabetes patientsMikael K Poulsen
Department of Endocrinology, Odense University Hospital, Kløvervaenget 6, 5th Floor, 5000, Odense C, Denmark
J Nucl Cardiol 16:878-87. 2009..Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (T2DM) patients. We examined the relationship between CVD in different vascular territories... - Osteoprotegerin, thiazolidinediones treatment, and silent myocardial ischemia in type 2 diabetic patientsAriane Sultan
, CHU Montpellier, , Montpellier, France
Diabetes Care 31:593-5. 2008 - Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemiaMichael P Robich
Department of Surgery, Division of Cardiothoracic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI 02903, USA
Circulation 122:S142-9. 2010Resveratrol may provide protection against coronary artery disease. We hypothesized that supplemental resveratrol will improve cardiac perfusion in the ischemic territory of swine with hypercholesterolemia and chronic myocardial ischemia. - Intramyocardial injection of autologous bone marrow mononuclear cells for patients with chronic ischemic heart disease and left ventricular dysfunction (First Mononuclear Cells injected in the US [FOCUS]): Rationale and designJames T Willerson
Coordinating Center for Clinical Trials, The University of Texas, Health Science Center, Houston, TX 77030, USA
Am Heart J 160:215-23. 2010..Despite advances in these methods, CAD is a leading cause of recurrent ischemia and heart failure, posing significant morbidity and mortality risks along with increasing health costs in a large patient population worldwide... - Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) studyCarl J Pepine
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 55:2825-32. 2010..We investigated whether coronary microvascular dysfunction predicts major adverse outcomes during follow-up among women with signs and symptoms of ischemia... - Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemiaReut Fallach
Gonda Goldschmied Medical Diagnostic Research Center, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
J Mol Cell Cardiol 48:1236-44. 2010..Toll-like receptor 4 (TLR4) is involved in the acute myocardial dysfunction caused by septic shock and myocardial ischemia (MI)... - Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70Lihua Ao
Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USA
Am J Physiol Heart Circ Physiol 297:H21-8. 2009Cardiac surgery with global myocardial ischemia-reperfusion (I/R) induces a myocardial inflammatory response that impairs cardiac recovery... - Selective suction and pressure-regulated retroinfusion: an effective and safe approach to retrograde protection against myocardial ischemia in patients undergoing normal and high risk percutaneous transluminal coronary angioplastyP Boekstegers
Department of Internal Medicine I, Klinikum Grosshadern, University of Munich, Germany
J Am Coll Cardiol 31:1525-33. 1998We sought to study the safety, feasibility and efficacy of selective suction and pressure-regulated retroinfusion to protect against myocardial ischemia in patients undergoing normal risk and high risk balloon angioplasty. - Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusionM Chen
Scripps Research Institute and The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 276:30724-8. 2001Reperfusion after myocardial ischemia is associated with a rapid influx of calcium, leading to activation of various enzymes including calpain... - Flattening of oxygen pulse during exercise may detect extensive myocardial ischemiaEva C Munhoz
Cardiology Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
Med Sci Sports Exerc 39:1221-6. 2007..exercise testing has been proposed for the improvement of diagnostic accuracy of exercise-induced myocardial ischemia. In this study, we compare the oxygen pulse response to incremental treadmill exercise in patients with and .. - Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathyP Aukrust
Medical Department A, University of Oslo, Rikshospitalet, Norway
Am J Cardiol 83:376-82. 1999..The present study analyzing the complexity of the cytokine network in CHF, demonstrates profound disturbances in the levels of both inflammatory and anti-inflammatory mediators with a marked dysbalance favoring inflammatory effects... - Role of xanthine oxidoreductase in cardiac nitroso-redox imbalanceKonstantinos Tziomalos
Interdisciplinary Stem Cell Institute and Division of Cardiology, Leonard M Miller School of Medicine, University of Miami, Miami, FL, USA
Front Biosci 14:237-62. 2009..A growing understanding of XOR and its role in nitroso-redox imbalance has great potential to lead to improved pathophysiologic insights and possibly therapeutic advances... - Silent myocardial ischemiaDavid D Gutterman
Medical College of Wisconsin, Milwaukee, WI 53226, USA
Circ J 73:785-97. 2009..This review examines the clinical characteristics of silent myocardial ischemia, and explores mechanisms involved in the generation of angina pectoris... - Intravenous infusion of bone marrow mesenchymal stem cells improves myocardial function in a rat model of myocardial ischemiaTong Wang
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
Crit Care Med 35:2587-93. 2007We investigated the effects of three different sites for delivery of bone marrow mesenchymal stem cells (MSCs) in a rat model of myocardial ischemia. - In vivo porcine model of reperfused myocardial infarction: in situ double staining to measure precise infarct area/area at riskYoriyasu Suzuki
Division of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, California 94305, USA
Catheter Cardiovasc Interv 71:100-7. 2008..The aim of this study is to evaluate a catheter-based porcine model for reperfused myocardial infarction and investigate the appropriate location and duration of the occlusion... - Reviewing myocardial silent ischemia: specific patient subgroupsTheodoros Xanthos
Department of Experimental Surgery and Surgical Research N S Christeas, Athens School of Medicine, Athens, Greece
Int J Cardiol 124:139-48. 2008Silent myocardial ischemia (SMI) is a relatively common, yet poorly understood, clinical entity. The most accurate means of detecting SMI and the precise treatment endpoints remain unclear... - The risk of maternal ischaemic heart disease after gestational hypertensive diseaseAnna Karin Wikström
Department of Women s and Children s Health, Uppsala University, Sweden
BJOG 112:1486-91. 2005..The aim of this study was to investigate whether the risk of developing ischaemic heart disease (IHD) later in life increases with severity and recurrence of gestational hypertensive disease... - The effects of aetiology on outcome in patients treated with cardiac resynchronization therapy in the CARE-HF trialGerhard Wikstrom
Department of Cardiology, Institute of Medical Sciences, Akademiska Hospital, University of Uppsala, Uppsala, Sweden
Eur Heart J 30:782-8. 2009..The effect of the underlying cause of cardiac dysfunction on the response to cardiac resynchronization therapy (CRT) is unknown. This issue was addressed using data from the CARE-HF trial... - Identification of myocardial ischemia in the diabetic patient. Joint ALFEDIAM and SFC recommendationsJ Puel
French Society of Cardiology
Diabetes Metab 30:3S3-18. 2004 - Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) studyFrans J Th Wackers
Yale University School of Medicine, Section of Cardiovascular Medicine, 333 Cedar St Fitkin 3, New Haven, CT 06520, USA
Diabetes Care 30:2892-8. 2007The purpose of this study was to assess whether the prevalence of inducible myocardial ischemia increases over time in patients with type 2 diabetes. - Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injuryChristopher K Means
Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0636, USA
Am J Physiol Heart Circ Physiol 292:H2944-51. 2007..The role of S1P in regulating cardiomyocyte survival following in vivo myocardial ischemia-reperfusion (I/R) injury was examined by using mice in which specific S1P receptor subtypes were deleted... - An initial strategy of intensive medical therapy is comparable to that of coronary revascularization for suppression of scintigraphic ischemia in high-risk but stable survivors of acute myocardial infarctionJohn J Mahmarian
Methodist DeBakey Heart Center, Department of Cardiology, The Methodist Hospital, Houston, Texas 77030, USA
J Am Coll Cardiol 48:2458-67. 2006..The purpose of this study was to determine the relative benefit of intensive medical therapy compared with coronary revascularization for suppressing scintigraphic ischemia... - Markers for silent myocardial ischemia in diabetes. Are they helpful?E Cosson
Department of Endocrinology Diabetology Nutrition, Paris Nord University, Jean Verdier Hospital, AP HP, Bondy, France
Diabetes Metab 31:205-13. 2005Silent myocardial ischemia (SMI) and silent coronary stenoses (CS) are two to seven times more frequent in diabetic patients than in non-diabetic patients... - Reduced reactive O2 species formation and preserved mitochondrial NADH and [Ca2+] levels during short-term 17 degrees C ischemia in intact heartsMatthias L Riess
Anesthesiology Research Laboratory, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Cardiovasc Res 61:580-90. 2004..The close temporal relations of these factors during cooling and during ischemia suggest a causal link between mCa2+, mitochondrial energy balance, and ROS production... - Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemiaGuosheng Xiang
Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
J Biol Chem 280:39394-402. 2005..Here, we report that VDUP1 expression is significantly increased in rat hearts following acute myocardial ischemia, suggesting it may have important regulatory effects on cardiac physiological processes during periods of .. - Bcl-xL gene transfer protects the heart against ischemia/reperfusion injuryJianhua Huang
Department of Molecular Medicine, Sapporo Medical University, Sapporo, Japan
Biochem Biophys Res Commun 311:64-70. 2003..Thus, Bcl-xL may serve as a potential therapeutic tool for cardioprotection... - Morphine inhibits VEGF expression in myocardial ischemiaS Roy
Department of Pharmacology, University of Minnesota, Minneapolis Veterans Affairs Medical Center, Minneapois, MN 55417, USA
Surgery 134:336-44. 2003BACKGROUND: Vascular endothelial growth factor (VEGF) may contribute to the resolution of myocardial ischemia by stimulating collateral circulation. Morphine analgesia after myocardial ischemia is thought to increase infarct size... - Electromagnetic guidance for catheter-based transendocardial injection: a platform for intramyocardial angiogenesis therapy. Results in normal and ischemic porcine modelsR Kornowski
Cardiovascular Research Foundation, Washington Hospital Center, Washington, DC 20010, USA
J Am Coll Cardiol 35:1031-9. 2000..To test the feasibility of myocardial angiogenic gene expression using a novel catheter-based transendocardial injection system... - Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusionLeo G Kevin
Anesthesiology Research Laboratories, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
Am J Physiol Heart Circ Physiol 284:H566-74. 2003..Our results directly demonstrate how intracellular ROS increase in intact hearts during IPC and I/R and clarify the role of ROS in triggering and mediating IPC... - H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 geneT Yoshida
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1110, USA
Circulation 103:1695-701. 2001..Heme oxygenase-1 (H(mox-1)) has been implicated in protection of cells against ischemia/reperfusion injury... - Value of acute rest sestamibi perfusion imaging for evaluation of patients admitted to the emergency department with chest painM C Kontos
Medical College of Virginia Virginia Commonwealth University, Richmond 23298 0128, USA
J Am Coll Cardiol 30:976-82. 1997.... - LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injuryKazuaki Kataoka
Department of Cardiovascular Medicine, Graduate School of Medicine Kyoto University, Kyoto, Japan
Biochem Biophys Res Commun 300:656-60. 2003..To investigate possible roles of LOX-1 in myocardial ischemia-reperfusion injury, rats were subjected to coronary artery ligation for 1h followed by reperfusion for 2h... - Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipinGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology, CNR Unit for the Study of Mitochondria and Bioenergetics, Bari, Italy
FASEB J 17:714-6. 2003..It is proposed that the loss of complex III activity in reperfused rat hearts can be mainly ascribed to a loss of cardiolipin content, due to oxidative attack by oxygen free radicals... - Selective pressure-regulated retroinfusion of fibroblast growth factor-2 into the coronary vein enhances regional myocardial blood flow and function in pigs with chronic myocardial ischemiaGeorges von Degenfeld
Internal Medicine I, Grosshadern, Grosshadern University Hospital, Munich, Germany
J Am Coll Cardiol 42:1120-8. 2003..CONCLUSIONS: Selective pressure-regulated retroinfusion increased tissue binding of FGF-2 and enhanced functionally relevant collateral perfusion compared with antegrade intracoronary delivery in pigs with chronic myocardial ischemia. - Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiographyE Nagel
Department of Internal Medicine Cardiology, German Heart Institute and Charité Campus Virchow, Humboldt University, Berlin, Germany
Circulation 99:763-70. 1999..abnormalities with dobutamine stress echocardiography (DSE) is an established method for the detection of myocardial ischemia. With ultrafast magnetic resonance tomography, identical stress protocols as used for echocardiography can .. - Value of electrocardiographically gated single-photon emission computed tomographic myocardial perfusion scintigraphy in a cohort of symptomatic postmenopausal womenJennifer H Mieres
New York University School of Medicine, New York, USA
Am J Cardiol 99:1096-9. 2007..001). In conclusion, results of this study indicate high diagnostic and prognostic accuracy for MPS in symptomatic postmenopausal women... - The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesisKyoji Urayama
UMR 7175 CNRS Universite Strasbourg I, Ecole Superieure de Biotechnologie de Strasbourg, Bld Sébastien Brandt BP 10413, F 67412 Illkirch, France
FASEB J 21:2980-93. 2007..Our results suggest that PKR1 may represent a novel therapeutic target to limit myocardial injury following ischemic events... - A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injuryJustin G Chapman
Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Pfizer Inc, Groton, CT 06340, USA
Eur J Pharmacol 456:59-68. 2002..Furthermore, these data indicate that cardioprotection via caspase-3/7 inhibition is attainable via a small molecule (nonpeptidic) inhibitor, a necessary step in making this approach therapeutically viable... - Myocardial protection in man--from research concept to clinical practiceDennis V Cokkinos
1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece
Heart Fail Rev 12:345-62. 2007..A continuous effort toward acute and chronically preserving myocardial integrity is a concept concerning both the researcher and the clinician... - Postconditioning does not reduce myocardial infarct size in an in vivo regional ischemia rodent modelJoan Dow
The Heart Institute, Good Samaritan Hospital, and Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90017, USA
J Cardiovasc Pharmacol Ther 12:153-63. 2007..Postconditioning did not reduce myocardial infarct size with any of these regimens... - Percutaneous coronary intervention and the no-reflow phenomenonWilliam J van Gaal
Department of Cardiology, Level 2, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Expert Rev Cardiovasc Ther 5:715-31. 2007..Compared with patients in whom no-reflow is transient, refractory no-reflow is associated with a markedly increased risk of 30-day mortality... - Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injuryD Schulman
Hatter Institute for Cardiovascular Studies, University College London Hospital and Medical School, WC1E 6DB, United Kingdom
Am J Physiol Heart Circ Physiol 281:H1630-6. 2001..These results suggest that there are defects within the IP signaling cascade of the aged heart. Clinical relevance is important if we are to use any IP-like mimetics to the benefit of an aging population... - Angiotensin II activates NADPH oxidase in isolated rat hearts subjected to ischaemia-reperfusionAlexandra Oudot
Laboratoire de Physiopathologie et Pharmacologie Cardio vasculaires Expérimentales, Faculties of Medicine and Pharmacy, 7, boulevard Jeanne d Arc, BP 87900, 21079 Dijon, France
Eur J Pharmacol 462:145-54. 2003..Our study demonstrates that ischaemia-reperfusion induces adaptative cardiac modifications, which allow exogenously added angiotensin II to stimulate myocardial NADPH oxidase through angiotensin AT(1) receptor activation... - Protective effects of xanthones against myocardial ischemia-reperfusion injury in ratsDe-Jian Jiang
Department of Pharmacology, School of Pharmaceutic Sciences, Central South University, Changsha 410078, China
Acta Pharmacol Sin 24:175-80. 2003AIM: To investigate the protective effect of xanthones against myocardial ischemia-reperfusion injury in rats... - Cardioprotective effects of novel tetrahydroisoquinoline analogs of nitrobenzylmercaptopurine riboside in an isolated perfused rat heart model of acute myocardial infarctionZ Zhu
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Ave, Suite 327, Memphis, TN 38163, USA
Am J Physiol Heart Circ Physiol 292:H2921-6. 2007..Infarct size was more effectively reduced by compound 4 than by NBMPR (P<0.02). These new tetrahydroisoquinoline NBMPR analogs are not only potent cardioprotective agents but are, also, more effective than NBMPR in this model... - Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acidMatthias L Riess
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
Anesthesiology 98:387-95. 2003.... - Deleterious myocardial consequences induced by intermittent hypoxia are reversed by erythropoietinA Ramond
Laboratoire HP2, Hypoxie Physio Pathologie Respiratoire et Cardiovasculaire, EA 3745, ERI 0017, Institut Jean Roget, BP 170, 38042 Grenoble Cedex 9, France
Respir Physiol Neurobiol 156:362-9. 2007..In conclusion, rhEPO administration before or after ischemia can protect isolated rat myocardium in a dose dependent manner and efficiently prevents the higher sensitivity to the infarction induced by previous intermittent hypoxia... - Efficacy of ischaemic preconditioning in the eNOS overexpressed working mouse heart modelEugene F du Toit
Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, South Africa
Eur J Pharmacol 556:115-20. 2007..These hearts may be maximally protected against ischaemia/reperfusion injury by their elevated endogenous NO levels...
Research Grants
- Modulation of Mitochondrial Function by Pro-OxidantsLUKE IGNATIUS SZWEDA; Fiscal Year: 2010..Mitochondria likely play a central role in myocardial ischemia/reperfusion injury...
- Antiarrhythmic Mechanisms in the Hearts of Hibernating MammalsLai Hua Xie; Fiscal Year: 2010..SCD often occurs during acute myocardial ischemia or infarction...
- Proteolytic Regulation of Troponin T & Cardiac FunctionJian Ping Jin; Fiscal Year: 2010..We recently reported a restricted N-terminal proteolysis of cTnT in myocardial ischemia-reperfusion (Zhang et al., Biochemistry 45:11681-94, 2006) and pressure overload (Feng et al., J. Physiol...
- Mechanisms of Cardiac Afferents and CNS Reflex ProcessingJOHN C contact LONGHURST; Fiscal Year: 2010..inhibitory (vagal afferent) and excitatory (sympathetic or spinal afferent) reflexes are manifested during myocardial ischemia and reperfusion...
- Surgical Intramyocardial Angiogenesis in a Model of Endothelial DysfunctionFrank W Sellke; Fiscal Year: 2010..inducing improvements in myocardial flow and left ventricular function in a large animal model of chronic myocardial ischemia. However, clinical trials have thus far failed to demonstrate that therapeutic angiogenesis is as effective ..
- Histone Deacetylase Inhibition: A Novel Approach to CardioprotectionTing C Zhao; Fiscal Year: 2010..b>Myocardial ischemia/reperfusion injury is still a major unsolved problem...
- CNS AUTONOMIC REGULATION BY ELECTROACUPUNCTUREJohn Longhurst; Fiscal Year: 2002..An initial study demonstrated that low frequency EA ameliorates myocardial ischemia by reducing myocardial oxygen demand in a feline model of reversible ischemia...
- Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 DiabetesRodica Pop Busui; Fiscal Year: 2010..Cardiac autonomic neuropathy (CAN) is associated with an increased prevalence of silent myocardial ischemia, and is an independent predictor of increased cardiac mortality...
- Proteasome, protein oxidation, and cardiomyocyte function.Xuejun Wang; Fiscal Year: 2010Numerous studies have shown that proteins are modified during myocardial ischemia. Earlier studies focused on the role of the Cadependent proteases to explain loss of contractile proteins during myocardial ischemia...
- Cardioprotective Signaling following Phosphodiesterase-5 InhibitionRAKESH KUKREJA; Fiscal Year: 2009..AMI is caused by a sudden thrombotic obstruction to the flow in a coronary artery branch leading to myocardial ischemia (lack of oxygen) and tissue death...
- Modulation of Mitochondrial Function by Pro-OxidantsLuke Szweda; Fiscal Year: 2007..Mitochondria likely play a central role in myocardial ischemia/reperfusion injury...
- Cardioprotective Actions of Hydrogen SulfideDAVID JOSEPH LEFER; Fiscal Year: 2010..These physiological actions are ideal for the treatment of myocardial ischemia-reperfusion (MI-R) injury...
- Angiogenesis in a model of diabetes and endothelial dysfunctionFrank W Sellke; Fiscal Year: 2009..patients suffer from accelerated atherosclerosis and also exhibit a diminished angiogenic response to myocardial ischemia. Angiogenic therapy using growth factors such as vascular endothelial growth factor (VEGF) and fibroblast ..
- Role of C5a versus C5b-9 in Myocardial Ischemia and Reperfusion InjuryBenjamin Guikema; Fiscal Year: 2007Decades of research have shown that complement activation contributes to tissue injury following myocardial ischemia and reperfusion (MI/R)...
- Myocardial Ischemia-Reperfusion and Protein Phosphatase 2aPolly A Hofmann; Fiscal Year: 2010..Thus, these data and that of others led us to hypothesize that myocardial ischemia induces a change in methylation, oxidation, and/or phosphorylation of PP2aC to alter substrate targeting by ..
- Radical Intermediates of Nitric Oxide Synthase & Myocardial Ischemia ReperfusionAh Lim Tsai; Fiscal Year: 2010..NO) participates both in the normal cardiac physiology and various cardiac pathological events including myocardial ischemia and reperfusion injury...
- CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASERoberto Levi; Fiscal Year: 2000..H3R quiescent, yet fully activated in hyperadrenergic states, such as myocardial ischemia, when HA is copiously released...
- Histamine Receptor/Norepinephrine in Cardiac DysfunctionRoberto Levi; Fiscal Year: 2007In myocardial ischemia, arrhythmias due to excessive norepinephrine (NE) release cause high morbidity and mortality. Thus, reduction of NE release from cardiac sympathetic nerve endings (SNE) in myocardial ischemia is a critical goal...
- Discovery & Application of Proteomics-Based Biomarkers of Early Myocardial InjuryMarc S Sabatine; Fiscal Year: 2010..Our studies will specifically focus on myocardial ischemia and early injury, for which no suitable and clinically practical blood biomarkers presently exist...
- MECHANISMS OF ACTIVATION OF CARDIAC NOCICEPTORSHui Lin Pan; Fiscal Year: 2005DESCRIPTION (provided by the applicant): Patients with myocardial ischemia typically experience angina pectoris...
- Poly (ADP-Ribose) synthetase in expression of endotheliaBasilia Zingarelli; Fiscal Year: 2003..injury, and consequent adhesion of neutrophils to the vascular intima, is an early pathologic event in myocardial ischemia and reperfusion injury...