myocardial ischemia

Summary

Summary: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERIOSCLEROSIS), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).

Top Publications

  1. ncbi Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
  2. doi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
  3. ncbi Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    A A Kocher
    Department of Surgery, Columbia University, New York, New York, USA
    Nat Med 7:430-6. 2001
  4. ncbi Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
  5. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
  6. ncbi Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation
    Feng Gao
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 105:1497-502. 2002
  7. pmc Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 11:1096-103. 2005
  8. ncbi Preconditioning the diabetic heart: the importance of Akt phosphorylation
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospitals, Grafton Way, London, WC1E 6DB, UK
    Diabetes 54:2360-4. 2005
  9. ncbi Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:697-703. 2003
  10. doi Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion
    Yufeng Zhang
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
    Int J Cardiol 148:91-5. 2011

Detail Information

Publications270 found, 100 shown here

  1. ncbi Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    ..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates...
  2. doi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
    ..mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm...
  3. ncbi Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    A A Kocher
    Department of Surgery, Columbia University, New York, New York, USA
    Nat Med 7:430-6. 2001
    ....
  4. ncbi Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
    ....
  5. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  6. ncbi Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation
    Feng Gao
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 105:1497-502. 2002
    ..pathway involved in the antiapoptotic effect of insulin in vivo and to test the hypothesis that phosphorylation of eNOS by insulin may participate in the cardioprotective effect of insulin after myocardial ischemia and reperfusion.
  7. pmc Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 11:1096-103. 2005
    ..These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms...
  8. ncbi Preconditioning the diabetic heart: the importance of Akt phosphorylation
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospitals, Grafton Way, London, WC1E 6DB, UK
    Diabetes 54:2360-4. 2005
    ..To protect the diabetic myocardium, it appears necessary to increase the IPC stimulus to achieve the threshold for cardioprotection and a critical level of Akt phosphorylation to mediate myocardial protection...
  9. ncbi Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:697-703. 2003
    ..We investigated these issues in a Lewis rat model (ligation of the left anterior descending artery) of ischaemic cardiomyopathy...
  10. doi Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion
    Yufeng Zhang
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
    Int J Cardiol 148:91-5. 2011
    To study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R).
  11. ncbi Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process
    A L Moens
    Department of Cardiology, University of Antwerp, Belgium
    Int J Cardiol 100:179-90. 2005
    ..g. tetrahydrobiopterin). One of such agents could be folic acid. In this review article the authors give an overview of the recent insights concerning pathogenesis and therapeutic possibilities to prevent IR-induced injury...
  12. ncbi Long-term exposure to air pollution and incidence of cardiovascular events in women
    Kristin A Miller
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 356:447-58. 2007
    ..We examined the association of long-term exposure to particulate matter of less than 2.5 microm in aerodynamic diameter (PM2.5) with cardiovascular events...
  13. pmc Intramyocardial, autologous CD34+ cell therapy for refractory angina
    Douglas W Losordo
    Division of Cardiology, Northwestern Memorial Hospital, Northwestern University, Chicago, IL 60611, USA
    Circ Res 109:428-36. 2011
    ..A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can improve myocardial perfusion and function...
  14. ncbi Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice
    S F Yet
    Cardiovascular and Pulmonary and Critical Care, Division and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:168-73. 2001
    ..In vivo, myocardial ischemia and reperfusion experiments showed that infarct size was only 14...
  15. doi Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial
    Jan van Ramshorst
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    JAMA 301:1997-2004. 2009
    Previous studies have suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular (LV) function in patients with chronic myocardial ischemia.
  16. ncbi Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study
    Frans J Th Wackers
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Care 27:1954-61. 2004
    To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines.
  17. pmc Comparison of different adult stem cell types for treatment of myocardial ischemia
    Koen E A van der Bogt
    Laboratory of Cardiothoracic Transplantation, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Circulation 118:S121-9. 2008
    ..This study is designed to evaluate the therapeutic efficacy of 4 cell types in a murine model of myocardial infarction...
  18. doi Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study
    Hassan Abdel-Aty
    Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    J Am Coll Cardiol 53:1194-201. 2009
    This study was designed to determine whether imaging myocardial edema would identify acute myocardial ischemia before irreversible injury takes place.
  19. doi Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production
    Qian Wang
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China
    Antioxid Redox Signal 12:1155-65. 2010
    ....
  20. pmc Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 30:162-9. 2009
    ..To determine whether an ultrasensitive assay can permit quantification of changes in circulating cardiac troponin (Tn) in the setting of stress test-induced myocardial ischaemia...
  21. doi Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats
    Xiaorong Hu
    Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, China
    Eur J Pharmacol 638:84-9. 2010
    Minocycline has been shown to protect against myocardial ischemia and reperfusion injury. However, the mechanism remains unclear...
  22. pmc Effect of dietary omega-3 fatty acids on the heart rate and the heart rate variability responses to myocardial ischemia or submaximal exercise
    George E Billman
    Dept of Physiology and Cell Biology, Ohio State Univ, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 300:H2288-99. 2011
    ..g., exercise or acute myocardial ischemia), particularly in postmyocardial infarction (MI) patients, are unknown...
  23. pmc Relation between the frequency of CD34⁺ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes
    Ilkay Bozdag-Turan
    Department of Internal Medicine, Division of Cardiology, University Hospital Rostock, Germany
    Cardiovasc Diabetol 10:107. 2011
    ..Therefore, in our study, we analysed the correlation between the diseased coronary arteries and the frequency of CD34/45+ BM-CPCs in peripheral blood (PB) in patients with ischemic heart disease (IHD)...
  24. pmc Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitus
    Mikael K Poulsen
    Department of Endocrinology, Diabetes Research Center, Odense University Hospital, Odense, Denmark
    Cardiovasc Diabetol 10:76. 2011
    ..Plasma osteoprotegerin (OPG) has evolved as a biomarker for CVD. We examined the relationship between plasma OPG levels and different CVD manifestations in type 2 diabetes...
  25. ncbi Widespread coronary inflammation in unstable angina
    Antonino Buffon
    Institute of Cardiology, Catholic University, Rome
    N Engl J Med 347:5-12. 2002
    ..In unstable angina, activated leukocytes may be found in peripheral and coronary-sinus blood, but it is unclear whether they are selectively activated in the vascular bed of the culprit stenosis...
  26. doi Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
    Yonghai Lv
    Department of Medicinal Chemistry of Nature Product, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    J Pharm Biomed Anal 52:129-35. 2010
    b>Myocardial ischemia (MI) is a worldwide epidemic. Compound Danshen Tablets (CDTs), an herbal compound preparation, are widely used to treat MI in China...
  27. pmc Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia
    Adil A Khan
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:17944-8. 2006
    ..These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms...
  28. doi Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in rats
    Jeng Feng Lin
    Department of Cardiology, Buddhist Tzu Chi Hospital, Taipei branch and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Life Sci 83:313-7. 2008
    ..Its cardioprotective effects may be due to a reduction of atrial natriuretic peptide and transforming growth factor-beta1, which are known to protect the heart from detrimental remodeling...
  29. pmc Complementary prognostic values of stress myocardial perfusion and late gadolinium enhancement imaging by cardiac magnetic resonance in patients with known or suspected coronary artery disease
    Kevin Steel
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 120:1390-400. 2009
    ..We therefore tested the hypothesis that characterization of these 2 processes from coronary artery disease by CMR can provide complementary prognostic values...
  30. ncbi Proteasome mediates removal of proteins oxidized during myocardial ischemia
    Andras Divald
    Department of Medicine, Institute for Medical Research, North Shore Long Island Jewish Health System, New Hyde Park, NY 11042, USA
    Free Radic Biol Med 40:156-64. 2006
    Numerous proteins are known to be lost following myocardial ischemia/reperfusion yet little is known about the mediating proteinases...
  31. ncbi Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    T Matsui
    Program in Cardiovascular Gene Therapy, CVRC, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:330-5. 2001
    ..Akt may represent an important nodal target for therapy in ischemic and other heart disease...
  32. pmc AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
    Raymond R Russell
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Clin Invest 114:495-503. 2004
    ..Whether AMPK plays a critical role in the metabolic and functional responses to myocardial ischemia and reperfusion remains uncertain...
  33. ncbi Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium
    Antonio Abbate
    Department of Medicine, Virginia Commonwealth University MCV Campus, Richmond, VA, USA
    Eur Heart J 26:2039-45. 2005
    ..It is currently unclear whether ongoing or recurrent ischaemia is an independent determinant for increased apoptosis in peri-infarct viable myocardium...
  34. ncbi Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria
    E J Lesnefsky
    Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Physiol Heart Circ Physiol 280:H2770-8. 2001
    ..Cardiolipin content was preserved in IFM during ischemia. Thus cardiolipin is a relatively early target of ischemic mitochondrial damage, leading to loss of oxidative phosphorylation through cytochrome oxidase in SSM...
  35. ncbi Silent myocardial ischemia
    Peter F Cohn
    State University of New York Health Sciences Center, Stony Brook, NY 11794 8171, USA
    Circulation 108:1263-77. 2003
  36. ncbi Myocardial ischemia and reperfusion injury
    L Maximilian Buja
    Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Cardiovasc Pathol 14:170-5. 2005
    ..b>Myocardial ischemia results in a characteristic pattern of metabolic and ultrastructural changes that lead to irreversible ..
  37. ncbi Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia
    S Fuchs
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    J Am Coll Cardiol 37:1726-32. 2001
    ..We also defined, in vitro, whether bone marrow (BM) cells secrete vascular endothelial growth factor (VEGF) and macrophage chemoattractant protein-1 (MCP-1)...
  38. ncbi Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein
    Motonori Ando
    Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan
    Circulation 112:164-70. 2005
    b>Myocardial ischemia (MI) leads to derangements in cellular electrical stability and the generation of lethal arrhythmias. Vagal nerve stimulation has been postulated to contribute to the antifibrillatory effect...
  39. pmc Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice
    Omar Bouhidel
    Institut National de la Santé et de la Recherche Médicale U841, Equipe 3, Universite Paris 12, Creteil, France
    Am J Physiol Heart Circ Physiol 295:H1580-6. 2008
    ..The lack of enhanced phosphorylation by IPCD of Akt, ERK1/2, p70S6K1, and AMPK might partly explain the loss of cardioprotection in this experimental model of obese mice...
  40. ncbi Occupational physical activity, energy expenditure and 11-year progression of carotid atherosclerosis
    Niklas Krause
    Department of Medicine, University of California at San Francisco, UC Berkeley Richmond Field Station, Richmond CA 94804, USA
    Scand J Work Environ Health 33:405-24. 2007
    ..This study prospectively assessed the effects of occupational physical activity on atherosclerosis progression...
  41. ncbi Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury
    Masaya Takahashi
    Department of Medical Bioregulation, Division of Cardiovascular Surgery and Medicine, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Am J Physiol Heart Circ Physiol 291:H886-93. 2006
    ....
  42. ncbi Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:1114-20. 2005
    ..The possibility that EPCs could act as reservoirs of cytokines has been implied by several observations; however, a specific role for cytokine delivery has not been identified...
  43. ncbi Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio
    Marja Hedman
    A I Virtanen Institute, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Circulation 107:2677-83. 2003
    ..However, only limited data are available about local VEGF gene transfer given during angioplasty (PTCA) and stenting...
  44. doi Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy
    Leslee J Shaw
    Emory University School of Medicine, Atlanta, GA 30306, USA
    Circulation 117:1283-91. 2008
    Extent and severity of myocardial ischemia are determinants of risk for patients with coronary artery disease, and ischemia reduction is an important therapeutic goal...
  45. pmc Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury
    Marta A Paiva
    Hatter Cardiovascular Institute, Univ College London Hospitals, 67 Chenies Mews, London, WC1E 6HX, UK
    Am J Physiol Heart Circ Physiol 300:H2123-34. 2011
    ..Furthermore, this cardioprotective effect appears to be mediated through inhibition of mPTP opening. Our findings suggest that improving AMPK activation during ischemia can be another mechanism for protecting the ischemic heart...
  46. doi Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart
    Jagdip S Jaswal
    Mazankowski Alberta Heart Institute, Departments of Pediatrics and Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1813:1333-50. 2011
    ..This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  47. ncbi Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research
    R Bolli
    Division of Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    J Mol Cell Cardiol 33:1897-918. 2001
    Over the past decade, an enormous number of studies (>100) have focused on the role of nitric oxide (NO) in myocardial ischemia. It is important to distinguish the function of NO in unstressed (non-preconditioned) myocardium from its ..
  48. doi Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease
    Caterina Marciano
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 39:1199-206. 2012
    ..We assessed the impact of type 2 diabetes, in the presence of other major cardiovascular risk factors, on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (CAD)...
  49. ncbi Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig hearts
    Ruben Coronel
    Department of Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 73:386-94. 2007
    ..The underlying electrophysiologic mechanisms are poorly understood. We studied the arrhythmias and the electrophysiologic changes during regional ischemia in hearts from pigs fed a diet rich in fish oil...
  50. pmc The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction
    Jeanna C Perman
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Invest 121:2625-40. 2011
    ..These findings suggest that VLDLR-induced lipid accumulation in the ischemic heart worsens survival by increasing ER stress and apoptosis...
  51. pmc Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis
    Xiaofeng Hu
    Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40202, USA
    Circulation 116:654-63. 2007
    ..However, the role of the SDF-1alpha-CXCR4 axis in modulating myocardial ischemia/reperfusion injury is unknown.
  52. ncbi Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality
    J R Kersten
    Division of Cardiovascular Diseases, Department of Anesthesiology, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 278:H1218-24. 2000
    ..The results indicate that hyperglycemia is a major determinant of the extent of myocardial infarction in the dog...
  53. pmc Adenosine stress 64- and 256-row detector computed tomography angiography and perfusion imaging: a pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia
    Richard T George
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circ Cardiovasc Imaging 2:174-82. 2009
    ..However, in its current form, CTA is limited in its prediction of myocardial ischemia. The purpose of this study was to test whether adenosine stress computed tomography myocardial perfusion ..
  54. pmc Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study
    Aslan T Turer
    Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75230 9047, USA
    J Am Coll Cardiol 57:2398-405. 2011
    ....
  55. doi Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway
    Rajesh G Katare
    Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan
    J Mol Cell Cardiol 46:405-12. 2009
    ..the mechanism behind the protection induced by intermittent fasting in a rat model of established chronic myocardial ischemia (MI). Chronic MI was induced in rats by occlusion of the left coronary artery...
  56. pmc Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis
    David S Wald
    Department of Cardiology, Southampton General Hospital, Southampton SO16 6YD
    BMJ 325:1202. 2002
    ....
  57. doi Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: report of a case
    Shigeru Miyagawa
    Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Surg Today 39:133-6. 2009
    ..After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis...
  58. pmc Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage
    Andrew Webb
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, England
    Proc Natl Acad Sci U S A 101:13683-8. 2004
    Nitric oxide (NO.) is thought to protect against the damaging effects of myocardial ischemia-reperfusion injury, whereas xanthine oxidoreductase (XOR) normally causes damage through the generation of reactive oxygen species...
  59. pmc Protective ischaemia in patients: preconditioning and postconditioning
    Asger Granfeldt
    Department of Anesthesiology and Critical Care, Aarhus University, Aarhus, Denmark
    Cardiovasc Res 83:234-46. 2009
    ..This review will summarize the physiological preclinical data on preconditioning and Postcon that are relevant to their translation to clinical therapeutics and treatment...
  60. doi Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro
    Shu yan Han
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, PR China
    Phytomedicine 16:694-702. 2009
    ..In this study, we investigated the anti-myocardial ischemia effects of a purified extract of C. tinctorius (ECT) both in vivo and in vitro...
  61. ncbi Clinical, imaging, and pathological characteristics of left ventricular thrombus: a comparison of contrast-enhanced magnetic resonance imaging, transthoracic echocardiography, and transesophageal echocardiography with surgical or pathological validation
    Monvadi B Srichai
    Center for Integrated Non Invasive Cardiovascular Imaging of Department of Radiology Section of Cardiovascular Imaging, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 152:75-84. 2006
    ....
  62. ncbi Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of "remote preconditioning"
    A Takaoka
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 33:556-64. 1999
    This study examined the changes in myocardial energy metabolism during myocardial ischemia after "remote preconditioning" and investigated the involvement of adenosine receptors in the mechanisms of this effect.
  63. pmc Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery
    John Terrovitis
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Am Coll Cardiol 54:1619-26. 2009
    ..The aim of this study was to quantify acute myocardial retention of cardiac-derived stem cells (CDCs) and evaluate different delivery methods with positron emission tomography (PET)...
  64. ncbi Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats
    Y M Lee
    Department of Pharmacology, National Defense Medical Center, PO Box 90048-504, Nei-Hu, Taipei, Taiwan
    Eur J Pharmacol 422:159-67. 2001
    ..and activation of neutrophils are strongly implicated as important pathophysiological mechanisms mediating myocardial ischemia/reperfusion injury. It has been proven that various antioxidants have cardioprotective effects...
  65. ncbi Effect of acute global ischemia on the upper limit of vulnerability: a simulation study
    Blanca Rodriguez
    Dept of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA
    Am J Physiol Heart Circ Physiol 286:H2078-88. 2004
    ..The insight provided by this study furthers our understanding of mechanisms by which acute ischemia-induced changes at the ionic level modulate cardiac vulnerability to electric shocks...
  66. ncbi Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro
    Wei Dong Zhang
    Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P R China
    Planta Med 72:4-8. 2006
    ..However, the effects of astragaloside IV on myocardial ischemia and its mechanisms of action remain largely unknown...
  67. ncbi Stress-activated protein kinase phosphorylation during cardioprotection in the ischemic myocardium
    R M Fryer
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H1184-92. 2001
    ..The data also suggest that activation of JNK during early reperfusion may be an important component of cardioprotection...
  68. doi Sudden cardiac death and myocardial ischemia indicators: a comparative study of four immunohistochemical markers
    Carlo P Campobasso
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Am J Forensic Med Pathol 29:154-61. 2008
    ..cellular antigens, their distribution patterns have been studied among a group of 18 SCD cases in which a myocardial ischemia was strongly suspected...
  69. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  70. pmc Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London Hospitals and Medical School, 67 Chenies Mews, London, WC1E 6HX, UK
    Basic Res Cardiol 105:677-86. 2010
    ..These have been proposed to provide guidance on the design and execution of both preclinical and clinical cardioprotection studies in order to facilitate the translation of future novel cardioprotective strategies for patient benefit...
  71. ncbi Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha
    Yoshihiko Kakinuma
    Department of Cardiovascular Control, Kochi Medical School, Nankoku 783 8505, Japan
    FEBS Lett 579:2111-8. 2005
    ..Dominant-negative HIF-1alpha inhibited the cell protective effect of ACh. In acute myocardial ischemia, vagal nerve stimulation increased HIF-1alpha expression and reduced the infarct size...
  72. ncbi Decision making with cardiac troponin tests
    Elliott M Antman
    N Engl J Med 346:2079-82. 2002
  73. pmc BOLD cardiovascular magnetic resonance at 3.0 tesla in myocardial ischemia
    Robert Manka
    Department of Internal Medicine Cardiology, German Heart Institute, Berlin, Germany
    J Cardiovasc Magn Reson 12:54. 2010
    ....
  74. pmc Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin
    D Roy
    Heart 92:113-4. 2006
  75. ncbi Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis
    Joris R De Groot
    Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, PO Box 22700, Amsterdam 1100 DE, The Netherlands
    Cardiovasc Res 62:323-34. 2004
    Sudden cardiac death forms a major cause of mortality. Myocardial ischemia-induced ventricular fibrillation (VF) is frequently the underlying mechanism...
  76. ncbi Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection
    Chuanfu Li
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Cardiovasc Res 61:538-47. 2004
    Immune and inflammatory signaling pathways, initiated by the innate response, are involved in myocardial ischemia/reperfusion (I/R) injury...
  77. pmc Myocardial viability and survival in ischemic left ventricular dysfunction
    Robert O Bonow
    Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N Michigan Ave, Suite 1006, Chicago, IL 60611, USA
    N Engl J Med 364:1617-25. 2011
    ..However, the efficacy of this approach is uncertain...
  78. ncbi ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs
    Dezhi Xing
    Department of Internal Medicine, University of Iowa College of Medicine and VA Medical Center, Iowa City, Iowa 52242, USA
    J Cardiovasc Electrophysiol 14:510-20. 2003
    ..The aim of this study was to determine if the stable antiarrhythmic peptide (AAP) analogue ZP123 increases gap junctional intercellular conductance and prevents reentrant ventricular tachycardia (VT) during coronary artery occlusion...
  79. ncbi Osteoprotegerin: a novel independent marker for silent myocardial ischemia in asymptomatic diabetic patients
    Antoine Avignon
    CHU Montpellier, Metabolic Diseases Department, Lapeyronie Hospital, Montpellier, France
    Diabetes Care 30:2934-9. 2007
    We sought to evaluate osteoprotegerin, an inhibitor of osteoclastogenesis involved in atherosclerosis, and other novel risk factors as predictive markers of silent myocardial ischemia (SMI).
  80. ncbi Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion
    Scott J Cameron
    Department of Pharmacology Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS Lett 566:255-60. 2004
    ..We propose a novel role for BMK1 in protecting the heart from ischemia/reperfusion-induced cardiac injury...
  81. doi Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66(Shc) and monoamine oxidase
    Fabio Di Lisa
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Basic Res Cardiol 104:131-9. 2009
    ..Finally, recent evidence will be reviewed that highlight the relevance of mitochondrial ROS formation also in myocardial failure and atherosclerosis...
  82. ncbi Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure
    Habib M Razavi
    Victoria Research Laboratories, 6th Floor, Lawson Health Research Institute, London Health Sciences Centre, Department of Medicine, University of Western Ontario, 800 Commissioners Road, London, Ontario, Canada N6A 4G5
    Pharmacol Ther 106:147-62. 2005
    ..by nitric oxide (NO) and to discuss the potential role that NO plays in cardiomyocyte apoptosis during myocardial ischemia/reperfusion and development of heart failure...
  83. ncbi Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats
    S Senthil
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu 608 002, India
    Toxicol Pathol 35:418-23. 2007
    ..was designed to investigate the protective effect of oleanolic acid (OA) against isoproterenol-induced myocardial ischemia in rat myocardium. Wistar strain rats were pretreated with OA (20, 40, and 60 mg/kg, s...
  84. ncbi Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies
    Christof Stamm
    Department of Cardiac Surgery, University of Rostock, Rostock, Germany
    J Thorac Cardiovasc Surg 133:717-25. 2007
    ..We then tested the hypothesis that CABG plus CD133+ cell injection would result in better contractile function than CABG alone...
  85. ncbi The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat
    A Sivarajah
    Centre for Experimental Medicine, Nephrology and Critical Care, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Shock 26:154-61. 2006
    We investigated whether (endogenous) hydrogen sulfide (H2S) protects the heart against myocardial ischemia and reperfusion injury...
  86. ncbi Switch from caspase-dependent to caspase-independent death during heart development: essential role of endonuclease G in ischemia-induced DNA processing of differentiated cardiomyocytes
    Núria Bahi
    Laboratori d Investigacio, Hospital Arnau de Vilanova, Department of Ciències Mèdiques Bàsiques, Universitat de Lleida, Av Rovira Roure, 80 25198 Lleida, Spain
    J Biol Chem 281:22943-52. 2006
    ....
  87. pmc Mechanisms of sudden cardiac death
    Michael Rubart
    Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5225, USA
    J Clin Invest 115:2305-15. 2005
    ..Here, we review the role of aberrant intracellular Ca handling, ionic imbalances associated with acute myocardial ischemia, neurohumoral changes, and genetic predisposition in the pathogenesis of SCD due to cardiac arrhythmia...
  88. ncbi Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria
    Qun Chen
    Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Cell Physiol 294:C460-6. 2008
    ..Thus ischemic damage to the ETC increased both the capacity and the net production of H(2)O(2) from complex I and complex III and sets the stage for an increase in ROS production during reperfusion as a mechanism of cardiac injury...
  89. ncbi Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
    Anne Hamacher-Brady
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:29776-87. 2006
    ....
  90. doi Mitral gradients and frequency of recurrence of mitral regurgitation after ring annuloplasty for ischemic mitral regurgitation
    Matthew L Williams
    Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Thorac Surg 88:1197-201. 2009
    ..We hypothesized that surgical revascularization and annuloplasty lead to a durable repair, but may also lead to increased mitral gradients that could limit the benefit of the repair technique...
  91. doi Restrictive annuloplasty for ischemic mitral regurgitation may induce functional mitral stenosis
    Julien Magne
    Laval Hospital Research Center Quebec Heart Institute, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 51:1692-701. 2008
    ..The purpose of this study was to evaluate mitral valve hemodynamic performance and functional capacity in patients with ischemic mitral regurgitation (MR) who underwent restrictive mitral valve annuloplasty (MVA)...
  92. doi CMR for characterization of the myocardium in acute coronary syndromes
    Erica Dall'Armellina
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Nat Rev Cardiol 7:624-36. 2010
    ....
  93. ncbi Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia
    Richard S Goldstein
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ, Manhasset, NY 11030, USA
    Shock 25:571-4. 2006
    Cerebral and myocardial ischemia, two of the leading causes of morbidity and mortality worldwide, are associated with inflammation that can lead to multiple organ failure and death...
  94. doi MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection
    Yanjie Lu
    Department of Pharmacology, Harbin Medical University, Harbin, Heilongjiang 150081, People s Republic of China
    Cardiovasc Res 84:434-41. 2009
    ..The present study was designed to investigate whether the beneficial effects of beta-blocker propranolol are related to regulation of microRNA miR-1...
  95. pmc Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    K A Jackson
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 107:1395-402. 2001
    ..3%, primarily in small vessels adjacent to the infarct. Our results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction...
  96. pmc Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70
    Lihua Ao
    Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Heart Circ Physiol 297:H21-8. 2009
    Cardiac surgery with global myocardial ischemia-reperfusion (I/R) induces a myocardial inflammatory response that impairs cardiac recovery...
  97. ncbi Osteoprotegerin, thiazolidinediones treatment, and silent myocardial ischemia in type 2 diabetic patients
    Ariane Sultan
    Service des Maladies Métaboliques, CHU Montpellier, Hopital Lapeyronie, Montpellier, France
    Diabetes Care 31:593-5. 2008
  98. ncbi Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion
    M Chen
    Scripps Research Institute and The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:30724-8. 2001
    Reperfusion after myocardial ischemia is associated with a rapid influx of calcium, leading to activation of various enzymes including calpain...
  99. ncbi Selective suction and pressure-regulated retroinfusion: an effective and safe approach to retrograde protection against myocardial ischemia in patients undergoing normal and high risk percutaneous transluminal coronary angioplasty
    P Boekstegers
    Department of Internal Medicine I, Klinikum Grosshadern, University of Munich, Germany
    J Am Coll Cardiol 31:1525-33. 1998
    We sought to study the safety, feasibility and efficacy of selective suction and pressure-regulated retroinfusion to protect against myocardial ischemia in patients undergoing normal risk and high risk balloon angioplasty.
  100. doi Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia
    Reut Fallach
    Gonda Goldschmied Medical Diagnostic Research Center, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Mol Cell Cardiol 48:1236-44. 2010
    ..Toll-like receptor 4 (TLR4) is involved in the acute myocardial dysfunction caused by septic shock and myocardial ischemia (MI)...
  101. pmc Ambient fine particulate matter exposure and myocardial ischemia in the Environmental Epidemiology of Arrhythmogenesis in the Women's Health Initiative (EEAWHI) study
    Zhu Ming Zhang
    Epidemiologic Cardiology Research Center, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27104, USA
    Environ Health Perspect 117:751-6. 2009
    ..Ambient particulate matter (PM) air pollution is associated with coronary heart disease, but the pathways underlying the association remain to be elucidated...

Research Grants88

  1. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..Mitochondria likely play a central role in myocardial ischemia/reperfusion injury...
  2. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2010
    ..SCD often occurs during acute myocardial ischemia or infarction...
  3. Proteolytic Regulation of Troponin T & Cardiac Function
    Jian Ping Jin; Fiscal Year: 2010
    ..We recently reported a restricted N-terminal proteolysis of cTnT in myocardial ischemia-reperfusion (Zhang et al., Biochemistry 45:11681-94, 2006) and pressure overload (Feng et al., J. Physiol...
  4. Mechanisms of Cardiac Afferents and CNS Reflex Processing
    JOHN C contact LONGHURST; Fiscal Year: 2010
    ..inhibitory (vagal afferent) and excitatory (sympathetic or spinal afferent) reflexes are manifested during myocardial ischemia and reperfusion...
  5. Surgical Intramyocardial Angiogenesis in a Model of Endothelial Dysfunction
    Frank W Sellke; Fiscal Year: 2010
    ..inducing improvements in myocardial flow and left ventricular function in a large animal model of chronic myocardial ischemia. However, clinical trials have thus far failed to demonstrate that therapeutic angiogenesis is as effective ..
  6. Histone Deacetylase Inhibition: A Novel Approach to Cardioprotection
    Ting C Zhao; Fiscal Year: 2010
    ..b>Myocardial ischemia/reperfusion injury is still a major unsolved problem...
  7. CNS AUTONOMIC REGULATION BY ELECTROACUPUNCTURE
    John Longhurst; Fiscal Year: 2002
    ..An initial study demonstrated that low frequency EA ameliorates myocardial ischemia by reducing myocardial oxygen demand in a feline model of reversible ischemia...
  8. Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 Diabetes
    Rodica Pop Busui; Fiscal Year: 2010
    ..Cardiac autonomic neuropathy (CAN) is associated with an increased prevalence of silent myocardial ischemia, and is an independent predictor of increased cardiac mortality...
  9. Proteasome, protein oxidation, and cardiomyocyte function.
    Xuejun Wang; Fiscal Year: 2010
    Numerous studies have shown that proteins are modified during myocardial ischemia. Earlier studies focused on the role of the Cadependent proteases to explain loss of contractile proteins during myocardial ischemia...
  10. Cardioprotective Signaling following Phosphodiesterase-5 Inhibition
    RAKESH KUKREJA; Fiscal Year: 2009
    ..AMI is caused by a sudden thrombotic obstruction to the flow in a coronary artery branch leading to myocardial ischemia (lack of oxygen) and tissue death...
  11. Modulation of Mitochondrial Function by Pro-Oxidants
    Luke Szweda; Fiscal Year: 2007
    ..Mitochondria likely play a central role in myocardial ischemia/reperfusion injury...
  12. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2010
    ..These physiological actions are ideal for the treatment of myocardial ischemia-reperfusion (MI-R) injury...
  13. Angiogenesis in a model of diabetes and endothelial dysfunction
    Frank W Sellke; Fiscal Year: 2009
    ..patients suffer from accelerated atherosclerosis and also exhibit a diminished angiogenic response to myocardial ischemia. Angiogenic therapy using growth factors such as vascular endothelial growth factor (VEGF) and fibroblast ..
  14. Role of C5a versus C5b-9 in Myocardial Ischemia and Reperfusion Injury
    Benjamin Guikema; Fiscal Year: 2007
    Decades of research have shown that complement activation contributes to tissue injury following myocardial ischemia and reperfusion (MI/R)...
  15. Myocardial Ischemia-Reperfusion and Protein Phosphatase 2a
    Polly A Hofmann; Fiscal Year: 2010
    ..Thus, these data and that of others led us to hypothesize that myocardial ischemia induces a change in methylation, oxidation, and/or phosphorylation of PP2aC to alter substrate targeting by ..
  16. Radical Intermediates of Nitric Oxide Synthase & Myocardial Ischemia Reperfusion
    Ah Lim Tsai; Fiscal Year: 2010
    ..NO) participates both in the normal cardiac physiology and various cardiac pathological events including myocardial ischemia and reperfusion injury...
  17. CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE
    Roberto Levi; Fiscal Year: 2000
    ..H3R quiescent, yet fully activated in hyperadrenergic states, such as myocardial ischemia, when HA is copiously released...
  18. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2007
    In myocardial ischemia, arrhythmias due to excessive norepinephrine (NE) release cause high morbidity and mortality. Thus, reduction of NE release from cardiac sympathetic nerve endings (SNE) in myocardial ischemia is a critical goal...
  19. Discovery & Application of Proteomics-Based Biomarkers of Early Myocardial Injury
    Marc S Sabatine; Fiscal Year: 2010
    ..Our studies will specifically focus on myocardial ischemia and early injury, for which no suitable and clinically practical blood biomarkers presently exist...
  20. MECHANISMS OF ACTIVATION OF CARDIAC NOCICEPTORS
    Hui Lin Pan; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Patients with myocardial ischemia typically experience angina pectoris...
  21. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..injury, and consequent adhesion of neutrophils to the vascular intima, is an early pathologic event in myocardial ischemia and reperfusion injury...