myocardial ischemia

Summary

Summary: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERIOSCLEROSIS), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).

Top Publications

  1. ncbi Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
  2. ncbi Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
  3. pmc Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 11:1096-103. 2005
  4. ncbi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
  5. ncbi Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:697-703. 2003
  6. ncbi Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    A A Kocher
    Department of Surgery, Columbia University, New York, New York, USA
    Nat Med 7:430-6. 2001
  7. ncbi Long-term exposure to air pollution and incidence of cardiovascular events in women
    Kristin A Miller
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 356:447-58. 2007
  8. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
  9. pmc Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion
    Peiyong Zhai
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 109:502-11. 2011
  10. pmc Intramyocardial, autologous CD34+ cell therapy for refractory angina
    Douglas W Losordo
    Division of Cardiology, Northwestern Memorial Hospital, Northwestern University, Chicago, IL 60611, USA
    Circ Res 109:428-36. 2011

Detail Information

Publications302 found, 100 shown here

  1. ncbi Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
    ....
  2. ncbi Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    ..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates...
  3. pmc Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 11:1096-103. 2005
    ..These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms...
  4. ncbi Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    Ruenn Chai Lai
    Institute of Medical Biology, ASTAR, 138648 Singapore
    Stem Cell Res 4:214-22. 2010
    ..mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm...
  5. ncbi Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:697-703. 2003
    ..We investigated these issues in a Lewis rat model (ligation of the left anterior descending artery) of ischaemic cardiomyopathy...
  6. ncbi Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    A A Kocher
    Department of Surgery, Columbia University, New York, New York, USA
    Nat Med 7:430-6. 2001
    ....
  7. ncbi Long-term exposure to air pollution and incidence of cardiovascular events in women
    Kristin A Miller
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 356:447-58. 2007
    ..We examined the association of long-term exposure to particulate matter of less than 2.5 microm in aerodynamic diameter (PM2.5) with cardiovascular events...
  8. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  9. pmc Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion
    Peiyong Zhai
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 109:502-11. 2011
    ..Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated...
  10. pmc Intramyocardial, autologous CD34+ cell therapy for refractory angina
    Douglas W Losordo
    Division of Cardiology, Northwestern Memorial Hospital, Northwestern University, Chicago, IL 60611, USA
    Circ Res 109:428-36. 2011
    ..A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can improve myocardial perfusion and function...
  11. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  12. pmc MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury
    Xiaohong Wang
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0575, USA
    Circulation 122:1308-18. 2010
    ..Recently, we and others observed that miR-494 was downregulated in murine I/R-injured and human infarcted hearts. However, the functional consequence of miR-494 in response to I/R remains unknown...
  13. ncbi Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models
    Vicente Bodi
    Cardiology Department, Hospital Clínico Universitario INCLIVA, Universidad de Valencia, Valencia, Spain
    J Am Coll Cardiol 59:1629-41. 2012
    The aim of this study was to investigate the metabolomic profile of acute myocardial ischemia (MIS) using nuclear magnetic resonance spectroscopy of peripheral blood serum of swine and patients undergoing angioplasty balloon-induced ..
  14. pmc Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4
    Yan Li
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:31308-19. 2011
    ..Herein we tested the hypothesis that myocardial ischemia activates interleukin receptor-associated kinase-1 (IRAK-1), a kinase critical for the innate immune ..
  15. ncbi Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process
    A L Moens
    Department of Cardiology, University of Antwerp, Belgium
    Int J Cardiol 100:179-90. 2005
    ..g. tetrahydrobiopterin). One of such agents could be folic acid. In this review article the authors give an overview of the recent insights concerning pathogenesis and therapeutic possibilities to prevent IR-induced injury...
  16. ncbi ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs
    Dezhi Xing
    Department of Internal Medicine, University of Iowa College of Medicine and VA Medical Center, Iowa City, Iowa 52242, USA
    J Cardiovasc Electrophysiol 14:510-20. 2003
    ..The aim of this study was to determine if the stable antiarrhythmic peptide (AAP) analogue ZP123 increases gap junctional intercellular conductance and prevents reentrant ventricular tachycardia (VT) during coronary artery occlusion...
  17. ncbi Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity
    Masaaki Ii
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:1114-20. 2005
    ..The possibility that EPCs could act as reservoirs of cytokines has been implied by several observations; however, a specific role for cytokine delivery has not been identified...
  18. ncbi Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation
    Feng Gao
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 105:1497-502. 2002
    ..pathway involved in the antiapoptotic effect of insulin in vivo and to test the hypothesis that phosphorylation of eNOS by insulin may participate in the cardioprotective effect of insulin after myocardial ischemia and reperfusion.
  19. ncbi Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia
    Richard S Goldstein
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ, Manhasset, NY 11030, USA
    Shock 25:571-4. 2006
    Cerebral and myocardial ischemia, two of the leading causes of morbidity and mortality worldwide, are associated with inflammation that can lead to multiple organ failure and death...
  20. pmc Preconditioning: a paradigm shift in the biology of myocardial ischemia
    Roberto Bolli
    Division of Cardiology, Univ of Louisville, 550 S Jackson St, ACB, 3rd Floor, Louisville, KY 40292, USA
    Am J Physiol Heart Circ Physiol 292:H19-27. 2007
    ....
  21. ncbi Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial
    Jan van Ramshorst
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    JAMA 301:1997-2004. 2009
    Previous studies have suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular (LV) function in patients with chronic myocardial ischemia.
  22. ncbi Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study
    Frans J Th Wackers
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes Care 27:1954-61. 2004
    To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines.
  23. ncbi Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospital, London, UK
    Circ Res 95:230-2. 2004
    ..In conclusion, we show for the first time that ischemic Postcond protects the myocardium by activating the prosurvival kinases PI3K-Akt, eNOS, and p70S6K in accordance with the RISK pathway...
  24. ncbi Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice
    S F Yet
    Cardiovascular and Pulmonary and Critical Care, Division and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:168-73. 2001
    ..In vivo, myocardial ischemia and reperfusion experiments showed that infarct size was only 14...
  25. ncbi Preconditioning the diabetic heart: the importance of Akt phosphorylation
    Andrew Tsang
    The Hatter Institute and Centre for Cardiology, University College London Hospitals, Grafton Way, London, WC1E 6DB, UK
    Diabetes 54:2360-4. 2005
    ..To protect the diabetic myocardium, it appears necessary to increase the IPC stimulus to achieve the threshold for cardioprotection and a critical level of Akt phosphorylation to mediate myocardial protection...
  26. ncbi Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study
    Hassan Abdel-Aty
    Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    J Am Coll Cardiol 53:1194-201. 2009
    This study was designed to determine whether imaging myocardial edema would identify acute myocardial ischemia before irreversible injury takes place.
  27. ncbi Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    T Matsui
    Program in Cardiovascular Gene Therapy, CVRC, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:330-5. 2001
    ..Akt may represent an important nodal target for therapy in ischemic and other heart disease...
  28. pmc CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: involving activation of PI3K/Akt signaling
    Zhijuan Cao
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Biochim Biophys Acta 1832:96-104. 2013
    Toll-like receptors (TLRs) have been implicated in myocardial ischemia/reperfusion (I/R) injury. The TLR9 ligand, CpG-ODN has been reported to improve cell survival. We examined effect of CpG-ODN on myocardial I/R injury.
  29. ncbi Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design
    Abbas Ali Qayyum
    Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, 9, Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    Regen Med 7:421-8. 2012
    ....
  30. ncbi Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing: 1991 to 2009
    Alan Rozanski
    Division of Cardiology and Department of Medicine, St Luke s Roosevelt Hospital, New York, New York, USA
    J Am Coll Cardiol 61:1054-65. 2013
    This study sought to assess whether the frequency of inducible myocardial ischemia during stress-rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has changed over time.
  31. pmc Adenosine stress 64- and 256-row detector computed tomography angiography and perfusion imaging: a pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia
    Richard T George
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circ Cardiovasc Imaging 2:174-82. 2009
    ..However, in its current form, CTA is limited in its prediction of myocardial ischemia. The purpose of this study was to test whether adenosine stress computed tomography myocardial perfusion ..
  32. pmc Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome
    Sebastiano Sciarretta
    Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Medical Science Building, Newark, NJ 07103, USA
    Circulation 125:1134-46. 2012
    ..Rheb is a GTP-binding protein that promotes cell survival and mediates the cellular response to energy deprivation (ED). The role of Rheb in the regulation of cell survival during ED has not been investigated in the heart...
  33. ncbi Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London, UK
    Heart Fail Rev 12:217-34. 2007
    ....
  34. pmc Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 30:162-9. 2009
    ..To determine whether an ultrasensitive assay can permit quantification of changes in circulating cardiac troponin (Tn) in the setting of stress test-induced myocardial ischaemia...
  35. pmc Effect of dietary omega-3 fatty acids on the heart rate and the heart rate variability responses to myocardial ischemia or submaximal exercise
    George E Billman
    Dept of Physiology and Cell Biology, Ohio State Univ, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 300:H2288-99. 2011
    ..g., exercise or acute myocardial ischemia), particularly in postmyocardial infarction (MI) patients, are unknown...
  36. ncbi Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production
    Qian Wang
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China
    Antioxid Redox Signal 12:1155-65. 2010
    ....
  37. pmc Relation between the frequency of CD34⁺ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes
    Ilkay Bozdag-Turan
    Department of Internal Medicine, Division of Cardiology, University Hospital Rostock, Germany
    Cardiovasc Diabetol 10:107. 2011
    ..Therefore, in our study, we analysed the correlation between the diseased coronary arteries and the frequency of CD34/45+ BM-CPCs in peripheral blood (PB) in patients with ischemic heart disease (IHD)...
  38. ncbi Widespread coronary inflammation in unstable angina
    Antonino Buffon
    Institute of Cardiology, Catholic University, Rome
    N Engl J Med 347:5-12. 2002
    ..In unstable angina, activated leukocytes may be found in peripheral and coronary-sinus blood, but it is unclear whether they are selectively activated in the vascular bed of the culprit stenosis...
  39. ncbi Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
    Yonghai Lv
    Department of Medicinal Chemistry of Nature Product, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    J Pharm Biomed Anal 52:129-35. 2010
    b>Myocardial ischemia (MI) is a worldwide epidemic. Compound Danshen Tablets (CDTs), an herbal compound preparation, are widely used to treat MI in China...
  40. pmc Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia
    Adil A Khan
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 103:17944-8. 2006
    ..These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms...
  41. ncbi Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in rats
    Jeng Feng Lin
    Department of Cardiology, Buddhist Tzu Chi Hospital, Taipei branch and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Life Sci 83:313-7. 2008
    ..Its cardioprotective effects may be due to a reduction of atrial natriuretic peptide and transforming growth factor-beta1, which are known to protect the heart from detrimental remodeling...
  42. pmc Complementary prognostic values of stress myocardial perfusion and late gadolinium enhancement imaging by cardiac magnetic resonance in patients with known or suspected coronary artery disease
    Kevin Steel
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 120:1390-400. 2009
    ..We therefore tested the hypothesis that characterization of these 2 processes from coronary artery disease by CMR can provide complementary prognostic values...
  43. pmc Comparison of different adult stem cell types for treatment of myocardial ischemia
    Koen E A van der Bogt
    Laboratory of Cardiothoracic Transplantation, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Circulation 118:S121-9. 2008
    ..This study is designed to evaluate the therapeutic efficacy of 4 cell types in a murine model of myocardial infarction...
  44. ncbi Proteasome mediates removal of proteins oxidized during myocardial ischemia
    Andras Divald
    Department of Medicine, Institute for Medical Research, North Shore Long Island Jewish Health System, New Hyde Park, NY 11042, USA
    Free Radic Biol Med 40:156-64. 2006
    Numerous proteins are known to be lost following myocardial ischemia/reperfusion yet little is known about the mediating proteinases...
  45. pmc AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
    Raymond R Russell
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Clin Invest 114:495-503. 2004
    ..Whether AMPK plays a critical role in the metabolic and functional responses to myocardial ischemia and reperfusion remains uncertain...
  46. ncbi Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria
    E J Lesnefsky
    Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Physiol Heart Circ Physiol 280:H2770-8. 2001
    ..Cardiolipin content was preserved in IFM during ischemia. Thus cardiolipin is a relatively early target of ischemic mitochondrial damage, leading to loss of oxidative phosphorylation through cytochrome oxidase in SSM...
  47. ncbi Silent myocardial ischemia
    Peter F Cohn
    State University of New York Health Sciences Center, Stony Brook, NY 11794 8171, USA
    Circulation 108:1263-77. 2003
  48. ncbi Myocardial ischemia and reperfusion injury
    L Maximilian Buja
    Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Cardiovasc Pathol 14:170-5. 2005
    ..b>Myocardial ischemia results in a characteristic pattern of metabolic and ultrastructural changes that lead to irreversible ..
  49. ncbi Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats
    Xiaorong Hu
    Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, China
    Eur J Pharmacol 638:84-9. 2010
    Minocycline has been shown to protect against myocardial ischemia and reperfusion injury. However, the mechanism remains unclear...
  50. pmc Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London Hospitals and Medical School, 67 Chenies Mews, London, WC1E 6HX, UK
    Basic Res Cardiol 105:677-86. 2010
    ..These have been proposed to provide guidance on the design and execution of both preclinical and clinical cardioprotection studies in order to facilitate the translation of future novel cardioprotective strategies for patient benefit...
  51. ncbi Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio
    Marja Hedman
    A I Virtanen Institute, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Circulation 107:2677-83. 2003
    ..However, only limited data are available about local VEGF gene transfer given during angioplasty (PTCA) and stenting...
  52. pmc Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis
    Xiaofeng Hu
    Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40202, USA
    Circulation 116:654-63. 2007
    ..However, the role of the SDF-1alpha-CXCR4 axis in modulating myocardial ischemia/reperfusion injury is unknown.
  53. ncbi Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia
    S Fuchs
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    J Am Coll Cardiol 37:1726-32. 2001
    ..We also defined, in vitro, whether bone marrow (BM) cells secrete vascular endothelial growth factor (VEGF) and macrophage chemoattractant protein-1 (MCP-1)...
  54. ncbi Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein
    Motonori Ando
    Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan
    Circulation 112:164-70. 2005
    b>Myocardial ischemia (MI) leads to derangements in cellular electrical stability and the generation of lethal arrhythmias. Vagal nerve stimulation has been postulated to contribute to the antifibrillatory effect...
  55. pmc Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice
    Omar Bouhidel
    Institut National de la Santé et de la Recherche Médicale U841, Equipe 3, Universite Paris 12, Creteil, France
    Am J Physiol Heart Circ Physiol 295:H1580-6. 2008
    ..The lack of enhanced phosphorylation by IPCD of Akt, ERK1/2, p70S6K1, and AMPK might partly explain the loss of cardioprotection in this experimental model of obese mice...
  56. ncbi Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury
    Masaya Takahashi
    Department of Medical Bioregulation, Division of Cardiovascular Surgery and Medicine, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Am J Physiol Heart Circ Physiol 291:H886-93. 2006
    ....
  57. ncbi Occupational physical activity, energy expenditure and 11-year progression of carotid atherosclerosis
    Niklas Krause
    Department of Medicine, University of California at San Francisco, UC Berkeley Richmond Field Station, Richmond CA 94804, USA
    Scand J Work Environ Health 33:405-24. 2007
    ..This study prospectively assessed the effects of occupational physical activity on atherosclerosis progression...
  58. ncbi Recent advances in stress echocardiography
    Michael W Cullen
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Cardiol 26:379-84. 2011
    ....
  59. ncbi Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 2:34-44. 2009
    ....
  60. ncbi Ivabradine induces an increase in ventricular fibrillation threshold during acute myocardial ischemia: an experimental study
    Fanny Vaillant
    Laboratory of Medical Pharmacology, INSERM ERI 22, Grange Blanche Medical School, Claude Bernard University, Lyon, France
    J Cardiovasc Pharmacol 52:548-54. 2008
    ..Tachycardia often facilitates ischemic ventricular fibrillation (VF)...
  61. ncbi Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE)
    Prakash Deedwania
    UCSF School of Medicine, San Francisco, Calif, USA
    Circulation 115:700-7. 2007
    ..However, no studies to date have assessed intensive versus moderate statin therapy in older patients with stable coronary syndromes...
  62. ncbi TNFα in myocardial ischemia/reperfusion, remodeling and heart failure
    Petra Kleinbongard
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Heart Fail Rev 16:49-69. 2011
    TNFα is crucially involved in the pathogenesis and progression of myocardial ischemia/reperfusion injury and heart failure...
  63. ncbi Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor
    Hai Feng Duan
    Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, 100850, Beijing, People s Republic of China
    Mol Ther 8:467-74. 2003
    ..a recognized angiogenic factor and endothelial cell chemoattractant, has been applied in the treatment of myocardial ischemia. In this study, we used a ligation model of proximal left anterior descending coronary artery of rats to ..
  64. ncbi Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia
    D Bar-Or
    Department of Trauma Research, Swedish Medical Center Englewood, CO 80110, USA
    Eur J Biochem 268:42-7. 2001
    Patients suffering from myocardial ischemia reportedly exhibit reduced in vitro binding of exogenous Co(2+) to the N-terminal of human serum albumin (HSA)...
  65. ncbi Silent myocardial ischemia is associated with autonomic neuropathy and other cardiovascular risk factors in type 1 and type 2 diabetic subjects, especially in those with microalbuminuria
    Ana Chico
    Institute of Diabetes, Fundación Sardà Farriol, Barcelona, Spain
    Endocrine 27:213-7. 2005
    The prevalence of silent myocardial ischemia (SMI) seems to be above average in diabetic subjects. As routine screening is costly, identifying high-risk populations is mandatory...
  66. pmc Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitus
    Mikael K Poulsen
    Department of Endocrinology, Diabetes Research Center, Odense University Hospital, Odense, Denmark
    Cardiovasc Diabetol 10:76. 2011
    ..Plasma osteoprotegerin (OPG) has evolved as a biomarker for CVD. We examined the relationship between plasma OPG levels and different CVD manifestations in type 2 diabetes...
  67. ncbi Chemokines in myocardial ischemia
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, The Methodist Hospital and the DeBakey Heart Center, Baylor College of Medicine, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Trends Cardiovasc Med 15:163-9. 2005
    ..Understanding of the role of chemokines in myocardial ischemia may result in novel strategies in the treatment of patients with ischemic heart disease.
  68. ncbi Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia
    Shu Q Liu
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208 3107, USA
    Am J Physiol Heart Circ Physiol 303:H1446-58. 2012
    b>Myocardial ischemia (MI) activates innate cardioprotective mechanisms, enhancing cardiomyocyte tolerance to ischemia. Here, we report a MI-activated liver-dependent mechanism for myocardial protection...
  69. pmc Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia/reperfusion in both humans and rats
    Qian Fan
    Department of Gerontology, Beijing Chaoyang Hospital Affiliate of Beijing Capital Medical University, 8 Gongtinan Road, Beijing, 100020, People s Republic of China
    Age (Dordr) 35:1017-26. 2013
    ..indicate aging results in significantly decreased cardiac function and increased myocardial apoptosis after myocardial ischemia/reperfusion (MI/R) in humans or rats. The underlying mechanisms of aging-exacerbated effects remain unknown...
  70. ncbi Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis
    Ahmed Abdel-Latif
    Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Arch Intern Med 167:989-97. 2007
    ..However, the effects of BMC transplantation in patients with ischemic heart disease remains unclear...
  71. ncbi Sudden cardiac death and myocardial ischemia indicators: a comparative study of four immunohistochemical markers
    Carlo P Campobasso
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Am J Forensic Med Pathol 29:154-61. 2008
    ..cellular antigens, their distribution patterns have been studied among a group of 18 SCD cases in which a myocardial ischemia was strongly suspected...
  72. ncbi Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice
    Vincent Braunersreuther
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    J Mol Cell Cardiol 48:789-98. 2010
    ..Our findings indicate that blocking chemokine receptor/ligand interactions might become a novel therapeutic strategy to reduce reperfusion injuries in patients during acute coronary syndromes...
  73. pmc Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 55:2825-32. 2010
    ..We investigated whether coronary microvascular dysfunction predicts major adverse outcomes during follow-up among women with signs and symptoms of ischemia...
  74. pmc Myocardial ischemia reperfusion injury: from basic science to clinical bedside
    Anja Frank
    University of Colorado Denver, Aurora, CO 80045, USA
    Semin Cardiothorac Vasc Anesth 16:123-32. 2012
    b>Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after myocardial ischemia, cardiac surgery or circulatory arrest...
  75. ncbi Therapeutic angiogenesis for myocardial ischemia revisited: basic biological concepts and focus on latest clinical trials
    Sofoclis Mitsos
    Department of Cardiothoracic Surgery, Onassion Cardiac Surgery Center, Athens, Greece
    Angiogenesis 15:1-22. 2012
    ..They discuss experimental studies in animal models of myocardial ischemia and outline available clinical studies on therapeutic angiogenesis for myocardial ischemia...
  76. ncbi Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research
    R Bolli
    Division of Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    J Mol Cell Cardiol 33:1897-918. 2001
    Over the past decade, an enormous number of studies (>100) have focused on the role of nitric oxide (NO) in myocardial ischemia. It is important to distinguish the function of NO in unstressed (non-preconditioned) myocardium from its ..
  77. ncbi Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease
    Caterina Marciano
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 39:1199-206. 2012
    ..We assessed the impact of type 2 diabetes, in the presence of other major cardiovascular risk factors, on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (CAD)...
  78. ncbi Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart
    Jagdip S Jaswal
    Mazankowski Alberta Heart Institute, Departments of Pediatrics and Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1813:1333-50. 2011
    ..This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  79. ncbi Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy
    Leslee J Shaw
    Emory University School of Medicine, Atlanta, GA 30306, USA
    Circulation 117:1283-91. 2008
    Extent and severity of myocardial ischemia are determinants of risk for patients with coronary artery disease, and ischemia reduction is an important therapeutic goal...
  80. pmc The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction
    Jeanna C Perman
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Invest 121:2625-40. 2011
    ..These findings suggest that VLDLR-induced lipid accumulation in the ischemic heart worsens survival by increasing ER stress and apoptosis...
  81. pmc Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study
    Aslan T Turer
    Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75230 9047, USA
    J Am Coll Cardiol 57:2398-405. 2011
    ....
  82. ncbi Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig hearts
    Ruben Coronel
    Department of Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 73:386-94. 2007
    ..The underlying electrophysiologic mechanisms are poorly understood. We studied the arrhythmias and the electrophysiologic changes during regional ischemia in hearts from pigs fed a diet rich in fish oil...
  83. ncbi Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality
    J R Kersten
    Division of Cardiovascular Diseases, Department of Anesthesiology, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 278:H1218-24. 2000
    ..The results indicate that hyperglycemia is a major determinant of the extent of myocardial infarction in the dog...
  84. ncbi Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro
    Shu yan Han
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, PR China
    Phytomedicine 16:694-702. 2009
    ..In this study, we investigated the anti-myocardial ischemia effects of a purified extract of C. tinctorius (ECT) both in vivo and in vitro...
  85. pmc Protective ischaemia in patients: preconditioning and postconditioning
    Asger Granfeldt
    Department of Anesthesiology and Critical Care, Aarhus University, Aarhus, Denmark
    Cardiovasc Res 83:234-46. 2009
    ..This review will summarize the physiological preclinical data on preconditioning and Postcon that are relevant to their translation to clinical therapeutics and treatment...
  86. ncbi Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of "remote preconditioning"
    A Takaoka
    First Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    J Am Coll Cardiol 33:556-64. 1999
    This study examined the changes in myocardial energy metabolism during myocardial ischemia after "remote preconditioning" and investigated the involvement of adenosine receptors in the mechanisms of this effect.
  87. ncbi Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: report of a case
    Shigeru Miyagawa
    Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Surg Today 39:133-6. 2009
    ..After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis...
  88. pmc Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage
    Andrew Webb
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, England
    Proc Natl Acad Sci U S A 101:13683-8. 2004
    Nitric oxide (NO.) is thought to protect against the damaging effects of myocardial ischemia-reperfusion injury, whereas xanthine oxidoreductase (XOR) normally causes damage through the generation of reactive oxygen species...
  89. ncbi Clinical, imaging, and pathological characteristics of left ventricular thrombus: a comparison of contrast-enhanced magnetic resonance imaging, transthoracic echocardiography, and transesophageal echocardiography with surgical or pathological validation
    Monvadi B Srichai
    Center for Integrated Non Invasive Cardiovascular Imaging of Department of Radiology Section of Cardiovascular Imaging, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 152:75-84. 2006
    ....
  90. pmc Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis
    David S Wald
    Department of Cardiology, Southampton General Hospital, Southampton SO16 6YD
    BMJ 325:1202. 2002
    ....
  91. ncbi Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway
    Rajesh G Katare
    Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan
    J Mol Cell Cardiol 46:405-12. 2009
    ..the mechanism behind the protection induced by intermittent fasting in a rat model of established chronic myocardial ischemia (MI). Chronic MI was induced in rats by occlusion of the left coronary artery...
  92. pmc Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery
    John Terrovitis
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Am Coll Cardiol 54:1619-26. 2009
    ..The aim of this study was to quantify acute myocardial retention of cardiac-derived stem cells (CDCs) and evaluate different delivery methods with positron emission tomography (PET)...
  93. ncbi Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium
    Antonio Abbate
    Department of Medicine, Virginia Commonwealth University MCV Campus, Richmond, VA, USA
    Eur Heart J 26:2039-45. 2005
    ..It is currently unclear whether ongoing or recurrent ischaemia is an independent determinant for increased apoptosis in peri-infarct viable myocardium...
  94. pmc Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury
    Marta A Paiva
    Hatter Cardiovascular Institute, Univ College London Hospitals, 67 Chenies Mews, London, WC1E 6HX, UK
    Am J Physiol Heart Circ Physiol 300:H2123-34. 2011
    ..Furthermore, this cardioprotective effect appears to be mediated through inhibition of mPTP opening. Our findings suggest that improving AMPK activation during ischemia can be another mechanism for protecting the ischemic heart...
  95. pmc The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia
    Philippe Pasdois
    School of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 436:493-505. 2011
    ..We further suggest that in hypoxia, production of H₂O₂ to activate signalling pathways may be also mediated by decreased oxidized cytochrome c and less superoxide scavenging...
  96. ncbi Ischemia-reperfusion injury in the aged heart: role of mitochondria
    Edward J Lesnefsky
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Arch Biochem Biophys 420:287-97. 2003
    ..Mitochondria are the major source of the reactive oxygen species that are generated during myocardial ischemia. Complex III is the major site of mitochondrial oxyradical production during ischemia in the adult heart...
  97. ncbi Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion
    Yufeng Zhang
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
    Int J Cardiol 148:91-5. 2011
    To study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R).
  98. ncbi Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion
    P S Ray
    Cardiovascular Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030 1110, USA
    FASEB J 15:393-402. 2001
    ..Transgene overexpression of alphaB crystallin was therefore successful in diminishing the independent contributory effects of both necrosis and apoptosis on I/R-induced cell death...
  99. pmc Depressive symptom dimensions and cardiovascular prognosis among women with suspected myocardial ischemia: A report from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation
    Sarah E Linke
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, CA 92120, USA
    Arch Gen Psychiatry 66:499-507. 2009
    ..Symptoms of depression and cardiovascular disease (CVD) overlap substantially. Differentiating between dimensions of depressive symptoms may improve our understanding of the relationship between depression and physical health...
  100. ncbi Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion
    Hajime Kin
    Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine, Atlanta, GA 30308 2225, USA
    Cardiovasc Res 62:74-85. 2004
    ..This study tested the hypothesis that the early minutes of reperfusion (R) during which postconditioning (Post-con) is applied are critical to its cardioprotection...
  101. ncbi A standardized definition of ischemic cardiomyopathy for use in clinical research
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 39:210-8. 2002
    ....

Research Grants72

  1. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..Mitochondria likely play a central role in myocardial ischemia/reperfusion injury...
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..b>Myocardial ischemia/reperfusion injury occurs in a wide spectrum of patients, ranging from survivors of out- of-hospital ..
  3. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..arterial occlusion or conversely arterial aneurysm formation, manifesting as sudden loss of vision, stroke, myocardial ischemia, aortic arch syndrome, and aneurysm rupture. Once diagnosed, the IVS are considered medical emergencies...
  4. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..Methods. Experiments will be conducted in anesthetized mice subjected to acute myocardial ischemia-reperfusion induced by reversible coronary ligation, and in cultured cardiomyocytes subjected to oxygen and ..
  5. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..Similar benefits have been observed in other rodent redox models, including myocardial ischemia/reperfusion injury and chlorine inhalational lung injury...
  6. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..SCD often occurs during acute myocardial ischemia or infarction...
  7. Purkinje Origin of Ischemic Ventricular Tachycardia and Fibrillation
    James B Martins; Fiscal Year: 2013
    ..by applicant): The aim of this project is to continue mechanistic investigation of a canine model of acute myocardial ischemia. This is a remarkably stable model of inducible ventricular tachycardia (VT) and ventricular fibrillation (..
  8. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..SDF1 is under active investigation as a treatment for prevention of myocardial ischemia/reperfusion injury...
  9. JNK exacerbates ischemia/reperfusion injury in hyperglycemic subjects.
    Keith A Webster; Fiscal Year: 2010
    ..We hypothesize that the exacerbated injury that accompanies myocardial ischemia/reperfusion in hyperglycemic subjects is at least in part the consequence of an early switch in the ..
  10. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..myocardium, which can cause cellular apoptosis, and most importantly, which are specifically upregulated in myocardial ischemia (Bnip3) and cardiac hypertrophy (Nix)...
  11. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..Micro-vascular rarefaction and remodeling are functionally consequential and exacerbate myocardial ischemia during ischemic insult (like chronic coronary artery obstruction), but would be improved by a change of ..
  12. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..if the dissection is located in the ascending part of the thoracic aorta since it may lead to global myocardial ischemia by compromising the aortic valve and blood flow through the coronary arteries...
  13. AKAP Regulation of PKA Targeting in the Heart
    Meredith Bond; Fiscal Year: 2009
    ..that encompass those proposed in this Competing Revision include (i) quantitative PCR;(ii) induction of myocardial ischemia (MI) in rats;(iii) adenoviral gene transfer into normal and failing rat hearts in vivo;(iv) cardiac ..
  14. Role of estrogen-related receptors in cardiac and skeletal muscle
    Janice M Huss; Fiscal Year: 2010
    ..in cardiac and skeletal muscle has important implications for disease states, including heart failure and myocardial ischemia, type 2 diabetes, and obesity...
  15. microRNA mediation of Endothelial Progenitor Cell function in Myocardial Ichemia
    Prasanna Krishnamurthy; Fiscal Year: 2013
    ..provide convincing evidence that anti-miR-377 therapy might enhance the EPC engraftment and function in myocardial ischemia leading to efficient myocardial repair...
  16. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    ..is viable, persistently dysfunctional myocardium that occurs in response to continuing or repetitive myocardial ischemia and is characterized by hypoperfusion without evidence of necrosis...
  17. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..We recently described augmented cardiac injury in acute hyperglycemic mice following myocardial ischemia and reperfusion...
  18. Inflammation and Repair in Cardiac Ischemia-Reperfusion
    Lewis C Becker; Fiscal Year: 2011
    ..myocardial injury, (3) the role of the transcription factor Stat3 in mediating the inflammatory response to myocardial ischemia-reperfusion injury, (4) the role of endothelial cell exocytosis in mediating inflammation after ischemia-..
  19. Endothelial Progenitor Cells and Particulate Air Pollution
    Arden Pope; Fiscal Year: 2013
    ..that acute or chronic exposure to air pollution is associated with adverse cardiovascular events including myocardial ischemia, stroke, arrhythmias, heart failure, sudden cardiac arrest and atherogenesis...
  20. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
    ..This application will complete our investigations into the role of MBL in myocardial ischemia by translating our bench studies to the bedside...
  21. Role of Mitochondria Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury
    Narayan G Avadhani; Fiscal Year: 2012
    ..We will study hepatic lesions, mt-dysfunction, myocardial ischemia/reperfusion injury in alcohol-treated or alcohol + LPS treated rats...
  22. Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 Diabetes
    RODICA BUSUI POP-BUSUI; Fiscal Year: 2013
    ..Cardiac autonomic neuropathy (CAN) is associated with an increased prevalence of silent myocardial ischemia, and is an independent predictor of increased cardiac mortality...
  23. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..These physiological actions are ideal for the treatment of myocardial ischemia-reperfusion (MI-R) injury...
  24. Mechanisms and Functions of Bimodally Targeted Cytochrome P450s to Mitochondria
    Narayan G Avadhani; Fiscal Year: 2012
    ..Additionally mt-CYP1B1 and CYP2C6 are induced in cardiomyocytes by hypoxia and myocardial ischemia. The objective of this proposal is to initiate studies on pathophysiological roles of mt- CYPs and HO-1 in ..
  25. Contractile Regulation of Cardiocyte Protein Synthesis
    Paul J McDermott; Fiscal Year: 2013
    ..Companion studies will be done using a murine model of myocardial ischemia and ischemia/reperfusion injury establish the physiological significance of the adult cardiomyocyte model ..
  26. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew J Campen; Fiscal Year: 2012
    ..reflect emission-induced impairment of endothelial cell function, leading to diminished coronary flow and myocardial ischemia in vulnerable subjects...
  27. Cardioprotective Signaling following Phosphodiesterase-5 Inhibition
    Rakesh C Kukreja; Fiscal Year: 2012
    ..AMI is caused by a sudden thrombotic obstruction to the flow in a coronary artery branch leading to myocardial ischemia (lack of oxygen) and tissue death...
  28. Genetic and Cellular Basis of Resistance/Sensitivity to Myocardial Ischemia
    Howard J Jacob; Fiscal Year: 2012
    ..identify the complex interactions through the use of specific genetic models with divergent phenotypes for myocardial ischemia such as the sensitive Dahl Salt-Sensitive and resistant Brown Norway strains...
  29. Inhibitors of the ENT4 Adenosine Transporter for Cardioprotection
    John K Buolamwini; Fiscal Year: 2010
    ..nucleosides, making it an intriguing transporter to study with respect to adenosine modulation in myocardial ischemia and reperfusion. Currently, there are no known potent or specific inhibitors of ENT4 Ado transport...
  30. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Objectives and Specific Aims Myocardial ischemia and infarction with resultant adverse ventricular remodeling and heart failure form an increasingly prevalent global health problem for which medical ..
  31. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myocardial ischemia-reperfusion injury is the most common cause of death in the US...
  32. Histone Deacetylase Inhibition: A Novel Approach to Cardioprotection
    Ting C Zhao; Fiscal Year: 2012
    ..b>Myocardial ischemia/reperfusion injury is still a major unsolved problem...
  33. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2012
    ..of our research is to define the cellular and molecular mechanisms determining the response of the heart to myocardial ischemia, with the long-term goal to develop novel therapeutic approaches for patients with coronary artery disease...
  34. NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONS
    David Mendelowitz; Fiscal Year: 2013
    ..recurrent apneas and intermittent hypoxia, and have an increased risk of hypertension, arrhythmias, myocardial ischemia and stroke...
  35. Regulation of IL-6-Type Cytokine Cardioprotective Signaling in the Ischemic Heart
    George W Booz; Fiscal Year: 2012
    ..role of myocardial and endothelial SOCS3 in ischemic preconditioning and will employ a closed-chest mouse myocardial ischemia-reperfusion model...
  36. Myocardial Injury Associated with Mitochondria-derived Oxygen Free Radical(s)
    Yeong Renn Chen; Fiscal Year: 2013
    ..have been detected in the mitochondrial complex I (NQR), complex II (SQR), and other ETC proteins during myocardial ischemia and reperfusion injury...
  37. ROS, Inflammation, and Cardioprotection in Type 2 Diabetes
    Rakesh C Kukreja; Fiscal Year: 2013
    ..and attenuates cell death (necrosis/apoptosis) and mitochondrial respiratory chain dysfunction following myocardial ischemia/reperfusion (I/R) in T2D...
  38. Sex Differences in Myocardial Ischemia Triggered by Emotional Factors after MI
    Viola Vaccarino; Fiscal Year: 2010
    ..One third to two thirds of patients with CHD have myocardial ischemia that is induced by psychological stressors...
  39. Cell Based Therapies for Cystic Fibrosis
    Tracey L Bonfield; Fiscal Year: 2012
    ..clinical research has demonstrated that cell-based therapies may improve left ventricular function, reduce myocardial ischemia and lead to improved lung function...
  40. Transfusion Trigger Trial in Coronary Artery Disease: A Pilot Study
    JEFFREY LEE CARSON; Fiscal Year: 2010
    ..Oxygen delivery to the myocardium is flow dependent and myocardial ischemia may be precipitated by low hemoglobin concentrations...
  41. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..b>Myocardial ischemia is both a frequent cause and a consequence of ventricular tachycardia and fibrillation, two potentially ..
  42. Genetic Control of Heart Function in a Hibernating Mammal
    Matthew T Andrews; Fiscal Year: 2010
    ..greatly reduced body temperature, metabolism and respiration- conditions that buy precious time in cases of myocardial ischemia, traumatic injury and cardiac arrest...
  43. Mechanisms of Cardiac Afferents and CNS Reflex Processing
    John C Longhurst; Fiscal Year: 2013
    ..inhibitory (vagal afferent) and excitatory (sympathetic or spinal afferent) reflexes are manifested during myocardial ischemia and reperfusion...
  44. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..goal is to validate 99mTc-labeled bispecific cytokine ligands for SPECT imaging of inflammation induced by myocardial ischemia and reperfusion...
  45. RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
    Robert Schneider; Fiscal Year: 2010
    ..changes include reductions in hypertension, psychosocial stress, insulin resistance-metabolic syndrome, myocardial ischemia, carotid atherosclerosis, left ventricular hypertrophy, and mortality rates...
  46. Effects of Cocoa Flavonols on Myocardial Infarction Size and Post-Injury Injury
    Francisco Villarreal; Fiscal Year: 2009
    ..we wish to provide evidence for the ability of cocoa and epicatechin to reduce neutrophil-mediated myocardial ischemia-reperfusion (IR) injury via a nitric oxide (NO) dependent mechanism...
  47. Mental Stress and Myocardial Ischemia after MI: Sex Differences and Mechanisms
    Viola Vaccarino; Fiscal Year: 2013
    ..In about half of patients with ischemic heart disease, myocardial ischemia can be induced by a psychological challenge;this "mental stress ischemia" provides a useful model for the ..
  48. TNRF1 Signaling Resistance in Ischemic Human Female Myocardium
    Daniel R Meldrum; Fiscal Year: 2010
    ..b>Myocardial ischemia and reperfusion injury is a leading cause of heart failure and death in civilized countries...
  49. RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells
    Luis A Ortiz; Fiscal Year: 2013
    ..Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury in mice...
  50. Cardiac metabolism and heart failure
    Rong Tian; Fiscal Year: 2010
    ..activation of PPAR? resulted in lipotoxic cardiomyopathy, contractile dysfunction and impaired response to myocardial ischemia while studies using chronic PPAR? activators showed no effect in cardiac remodeling...
  51. Myocardial salvage via coordinated induction of endogenous cardiac antioxidants
    Yunbo Li; Fiscal Year: 2010
    ..A large body of evidence supports a causal role for oxidative stress in various forms of CVD, especially myocardial ischemia- reperfusion injury. As such, exogenous antioxidant compounds have been used for intervention of CVD...
  52. Regulation of myocardial growth and death by autophagy
    Junichi Sadoshima; Fiscal Year: 2013
    ..Autophagy plays an adaptive role under energy starvation, such as myocardial ischemia, thereby mediating cell survival, whereas autophagy associates with programmed cell death under some ..
  53. Nitroso/redox balance in myocardial infarction
    Joshua M Hare; Fiscal Year: 2013
    ..GSNOR), which decomposes SNO bonds and last, that the well-known cardioprotective effects of NO during myocardial ischemia are mediated at least in part by S-nitrosylation of Ca+2 handling proteins...
  54. CYTOPROTECTIVE EFFECTS OF INFLAMMATION MEDIATED MEMBRANE REPAIR
    DOUGLAS LOWELL MANN; Fiscal Year: 2013
    ..goal of this research initiative is to delineate the cytoprotective role of proinflammatory cytokines in myocardial ischemia reperfusion (I/R) injury...
  55. Reliable Evaluation of Coronary Artery Disease using Myocardial BOLD MRI with CO2
    Rohan Dharmakumar; Fiscal Year: 2013
    ..arteries (stenosis) resulting in reduced blood flow and oxygen supplied to the heart muscle, results in myocardial ischemia - a condition where the oxygen demand of the myocardium is far in excess of the available supply...
  56. Epigenetic modification of endothelial progenitor cells into multipotent cells
    Rajasingh Johnson; Fiscal Year: 2010
    ..of autologous stem cells with enhanced lineage plasticity for subsequent testing in the setting of myocardial ischemia is an integral part of stem-cell research and it could be effectively used in cell therapy for regenerative ..
  57. PARASYMPATHETIC DYSFUNCTION IN OBESITY: EFFECT OF CHOLESTEROL ON VAChT
    Yifan Li; Fiscal Year: 2013
    ..issue in the United States 1 and worldwide 2 and is a major risk factor for hypertension, arrhythmia, myocardial ischemia, heart failure1, 3-6, and diabetes4, 7...
  58. Chlorinated Lipids in Myocardial Ischemia/Reperfusion
    David A Ford; Fiscal Year: 2013
    ..S. citizens per year. The patho- physiological sequelae following myocardial ischemia include depressed myocardial function leading to con- gestive heart failure and death...
  59. Metabolic Oscillations in Heart
    JAMES N contact WEISS; Fiscal Year: 2010
    ..and signaling pathways relevant to cardioprotection? 2) do glycolytic oscillations occur during acute myocardial ischemia, in which the ability of oxidative phosphorylation and the CK shuttle to buffer cellular ATP/ADP ratio is ..
  60. Therapeutic Protein C Activator for Myocardial Ischemia
    NORAH VERBOUT; Fiscal Year: 2013
    ..provided by applicant): Rapidly progressing occlusion of the coronary artery and the subsequent acute myocardial ischemia is the most prevalent primary cause of acute myocardial infarction (AMI) and death in the United States...
  61. IMPACT OF HYDROGEN SULFIDE ON OUTCOME OF CARDIAC ARREST AND CARDIOPULMONARY RESUS
    Fumito Ichinose; Fiscal Year: 2013
    ..It has been reported that administration of an H2S donor (Na2S) attenuates myocardial ischemia-reperfusion (IR) injury in rodents and pig...
  62. Computer Simulation of Acute Coronary Syndrome Care in the Emergency Department
    DANIEL JOSEPH FRANCE; Fiscal Year: 2010
    ..ACS is an umbrella term that includes all clinical findings consistent with acute myocardial ischemia. Because delays in delivery of evidence-based care affects outcome in ACS, this study will define ..
  63. MYOCARDIAL ISCHEMIA INDUCED BY INHALED ANESTHETICS
    CHARLES BUFFINGTON; Fiscal Year: 1993
    b>Myocardial ischemia remains a serious problem for anesthetized patients with coronary artery disease...
  64. Molecular Imaging of Ischemic Memory with Ultrasound - Transition to Humans
    Jonathan R Lindner; Fiscal Year: 2010
    ..and expedite the diagnosis of acute coronary syndromes by imaging molecular alterations that occur with myocardial ischemia ("ischemic memory" imaging)...
  65. ORGAN PROTECTION: ROLE OF ANESTHETICS
    JOHN TINKER; Fiscal Year: 1980
    ..far, tested the hypothesis that barbiturates might also exert specific protection against acute regional myocardial ischemia using a partial myocardial ischemia model in which we are able to measure myocardial oxygen consumption ..
  66. Angiogenesis in a model of diabetes and endothelial dysfunction
    Frank Sellke; Fiscal Year: 2009
    ..patients suffer from accelerated atherosclerosis and also exhibit a diminished angiogenic response to myocardial ischemia. Angiogenic therapy using growth factors such as vascular endothelial growth factor (VEGF) and fibroblast ..
  67. Role of C5a versus C5b-9 in Myocardial Ischemia and Reperfusion Injury
    Benjamin Guikema; Fiscal Year: 2007
    ..Decades of research have shown that complement activation contributes to tissue injury following myocardial ischemia and reperfusion (MI/R)...
  68. SOCIAL SUPPORT AND MYOCARDIAL ISCHEMIA
    David Sheffield; Fiscal Year: 1999
    ..Much myocardial ischemia occurring during daily life appears to be related to periods of psychological stress, and laboratory mental ..
  69. Myocardial Ischemia-Reperfusion and Protein Phosphatase 2a
    Polly A Hofmann; Fiscal Year: 2010
    ..Thus, these data and that of others led us to hypothesize that myocardial ischemia induces a change in methylation, oxidation, and/or phosphorylation of PP2aC to alter substrate targeting by ..
  70. INSULIN AND PROSTACYCLIN IN ISCHEMIC HEART DISEASE
    ASRU SINHA; Fiscal Year: 1990
    Platelets from patients with acute myocardial ischemia are hyperactive and resistant to the antiaggregatory effect of prostacyclin/prostaglandin E1...
  71. MECHANISMS OF ACTIVATION OF CARDIAC NOCICEPTORS
    Hui Lin Pan; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Patients with myocardial ischemia typically experience angina pectoris...
  72. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..injury, and consequent adhesion of neutrophils to the vascular intima, is an early pathologic event in myocardial ischemia and reperfusion injury...