Genomes and Genes
myocardial reperfusion injury
Summary: Damage to the MYOCARDIUM resulting from reperfusion of ischemic areas of the HEART. Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm. Reperfusion can cause EDEMA, injuries to cardiac myocytes (MYOCYTES, CARDIAC) and the conducting tissue with resultant ARRHYTHMIA. Degree of injury depends on the duration and extent of MYOCARDIAL ISCHEMIA before reperfusion, cytosolic calcium overload, and oxygen FREE RADICALS.
Publications260 found, 100 shown here
- The inflammatory response in myocardial infarctionNikolaos G Frangogiannis
Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
Cardiovasc Res 53:31-47. 2002..Elucidating the complex interactions and regulatory mechanisms responsible for cardiac repair may allow us to design effective inflammation-related interventions for the treatment of myocardial infarction...
- Myocardial reperfusion injuryDerek M Yellon
Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
N Engl J Med 357:1121-35. 2007
- Effect of cyclosporine on reperfusion injury in acute myocardial infarctionChristophe Piot
Hopital Arnaud de Villeneuve, Montpellier, France
N Engl J Med 359:473-81. 2008..In this pilot trial, we sought to determine whether the administration of cyclosporine at the time of percutaneous coronary intervention (PCI) would limit the size of the infarct during acute myocardial infarction...
- Mechanisms underlying acute protection from cardiac ischemia-reperfusion injuryElizabeth Murphy
Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Physiol Rev 88:581-609. 2008..Preconditioning activates a number of signaling pathways that reduce Ca(2+) overload and reduce activation of the mitochondrial permeability transition pore. The mitochondrial targets of cardioprotective signals are discussed in detail...
- Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioningPeter Ferdinandy
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
Pharmacol Rev 59:418-58. 2007....
- Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell deathTakashi Nakagawa
Laboratory of Molecular Genetics, Department of Post Genomics and Diseases, Japan Science and Technology Corporation, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Nature 434:652-8. 2005..In addition, CypD-deficient mice showed a high level of resistance to ischaemia/reperfusion-induced cardiac injury. Our results indicate that the CypD-dependent mPT regulates some forms of necrotic death, but not apoptotic death...
- The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusionKoen Raedschelders
Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine The University of British Columbia, Vancouver, BC, Canada
Pharmacol Ther 133:230-55. 2012..This overview is illustrated with example clinical studies that have attempted to translate these strategies to reduce the severity of ischemia-reperfusion injury during coronary artery bypass grafting surgery...
- Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioningZhi qing Zhao
Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine 550 Peachtree Street NE, Atlanta, GA 30308 2225, USA
Am J Physiol Heart Circ Physiol 285:H579-88. 2003..Post-con may be clinically applicable in coronary interventions, coronary artery bypass surgery, organ transplantation, and peripheral revascularization where reperfusion injury is expressed...
- Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of CardiologyMichel Ovize
Service d Explorations Fonctionnelles Cardiovasculaires and Inserm U886, Hospices Civils de Lyon, University of Lyon, France
Cardiovasc Res 87:406-23. 2010....
- Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trialHans Erik Bøtker
Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark
Lancet 375:727-34. 2010..We tested the hypothesis that remote ischaemic conditioning during evolving ST-elevation myocardial infarction, and done before primary percutaneous coronary intervention, increases myocardial salvage...
- Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetesKarin Przyklenk
Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Antioxid Redox Signal 14:781-90. 2011..We provide novel evidence for a profound-but potentially reversible-diabetes-induced defect in the cardioprotective efficacy of PostC...
- Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protectionMikiko Shimizu
Division of Cardiology, Hospital for Sick Children, Toronto, Canada
Clin Sci (Lond) 117:191-200. 2009..This cardioprotection is transferable across species, independent of local neurogenic activity, and requires opioid receptor activation...
- AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injuryRaymond R Russell
Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
J Clin Invest 114:495-503. 2004..Thus, AMPK is responsible for activation of glucose uptake and glycolysis during low-flow ischemia and plays an important protective role in limiting damage and apoptotic activity associated with ischemia and reperfusion in the heart...
- Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair: a randomized controlled trialZiad A Ali
Cambridge Cardiovascular Unit, Cambridge University Hospitals NHS Trust, Long Road, Cambridge, CB2 2QQ, UK
Circulation 116:I98-105. 2007..CONCLUSIONS: In patients undergoing elective open abdominal aortic aneurysm repair, RIPC reduces the incidence of postoperative myocardial injury, myocardial infarction, and renal impairment...
- Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injuryAmal K Bose
The Hatter Institute for Cardiovascular Studies, University College London Hospital and Medical School, Grafton Way, London WC1E, UK
Diabetes 54:146-51. 2005..This protection appears to involve activating multiple prosurvival kinases. This finding may represent a new therapeutic potential for this class of drug currently undergoing clinical trials in the treatment of type 2 diabetes...
- Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosisJiajia Fu
Department of Pharmacology and Toxicology, Sun Yat Sen University, Guangzhou, 510080, PR China
Eur J Pharmacol 568:213-21. 2007..The in vivo protection is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio...
- Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heartDavid P Sonne
Department of Biomedical Sciences and The Danish National Research, Foundation Centre for Heart Arrhythmia, University of Copenhagen, The Panum Institute 12 5, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
Regul Pept 146:243-9. 2008..The divergent agonist effects of Exe-4 and GLP-1(9-36), along with correspondingly divergent antagonistic efficacy of Exe(9-39), seem consistent with the presence of more than one type of GLP-1 receptor in this system...
- New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathwayDerek J Hausenloy
The Hatter Institute and Centre for Cardiology, University College London Hospital and Medical School, Grafton Way, London WC1E 6DB, UK
Cardiovasc Res 61:448-60. 2004....
- Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signalingNehmat Ghaboura
Protection et remodelage du myocarde, UPRES EA 3860, Faculte de Medecine, Universite d Angers, Rue Haute de Reculee, 49045 Angers Cedex 1, France
Basic Res Cardiol 106:147-62. 2011..In conclusion, direct inhibition of GSK-3β may provide an alternative strategy to protect diabetic hearts against I/R injury...
- Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic miceRaffaele Marfella
Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
Diabetes 53:454-62. 2004..The beneficial role of iNOS in modulating defensive responses against ischemia/reperfusion injury seems to be abolished in diabetic mice...
- Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanismsRei Shibata
Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
Nat Med 11:1096-103. 2005..These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms...
- Remote ischaemic preconditioning: underlying mechanisms and clinical applicationDerek J Hausenloy
The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London WC1E 6HX, UK
Cardiovasc Res 79:377-86. 2008..This article reviews the history and evolution of the phenomenon that is RIPC, the potential mechanistic pathways underlying its cardioprotective effect, and its emerging application in the clinical setting...
- Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injuryJakob Vinten-Johansen
Division of Cardiothoracic Surgery and Department of Physiology, Emory University School of Medicine, Atlanta, GA 30308 2225, USA
Cardiovasc Res 61:481-97. 2004..In addition, it will discuss the arguments for and against the involvement of neutrophils in responses to ischemia-reperfusion in experimental models, and the failure to translate experimentally successful therapy into clinical practice...
- The role of oxidants and free radicals in reperfusion injuryJay L Zweier
Davis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, 473 W 12th Ave, Columbus, OH 43210, USA
Cardiovasc Res 70:181-90. 2006..Ischemic preconditioning markedly decreases NO and oxidant generation, and this appears to be an important mechanism contributing to preconditioning-induced myocardial protection...
- Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4Cristian Dumitrescu
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 104:15081-6. 2007..Supplementation of BH(4) may therefore be an important therapeutic approach to reverse endothelial dysfunction in postischemic tissues...
- MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injuryXiaohong Wang
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0575, USA
Circulation 122:1308-18. 2010..Recently, we and others observed that miR-494 was downregulated in murine I/R-injured and human infarcted hearts. However, the functional consequence of miR-494 in response to I/R remains unknown...
- Oxidative stress stimulates autophagic flux during ischemia/reperfusionNirmala Hariharan
Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ, New Jersey Medical School, New Jersey, USA
Antioxid Redox Signal 14:2179-90. 2011..These results suggest that oxidative stress plays an important role in mediating autophagy during I/R, and that activation of autophagy through oxidative stress mediates myocardial injury in response to I/R in the mouse heart...
- A pore way to die: the role of mitochondria in reperfusion injury and cardioprotectionAndrew P Halestrap
Department of Biochemistry and The Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Biochem Soc Trans 38:841-60. 2010..MPTP inhibition also protects against congestive heart failure in hypertensive animal models. Thus the MPTP is a very promising pharmacological target for clinical practice, especially once more specific drugs are developed...
- Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological processA L Moens
Department of Cardiology, University of Antwerp, Belgium
Int J Cardiol 100:179-90. 2005..g. tetrahydrobiopterin). One of such agents could be folic acid. In this review article the authors give an overview of the recent insights concerning pathogenesis and therapeutic possibilities to prevent IR-induced injury...
- Cardioprotection from ischemia/reperfusion injury: basic and translational researchTetsuo Minamino
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
Circ J 76:1074-82. 2012..In the near future, large, multicenter, randomized, placebo-controlled, clinical trials will be required to determine whether pharmacological and ischemic conditioning can improve the clinical outcomes of patients with IHDs...
- Preconditioning and postconditioning: underlying mechanisms and clinical applicationDerek J Hausenloy
The Hatter Cardiovascular Institute, University College London, United Kingdom
Atherosclerosis 204:334-41. 2009..In this article, we provide an overview of 'conditioning' in all its various forms, describe the underlying mechanisms and review the recent clinical application of this emerging cardioprotective strategy...
- New concepts in reactive oxygen species and cardiovascular reperfusion physiologyLance B Becker
Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine MC5068, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Cardiovasc Res 61:461-70. 2004....
- α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal ratsNianlin Xie
Department of Cardiac Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, China
Arch Med Res 42:171-81. 2011..The present study attempted to investigate the effects of ALA intake on MI/R injury in normal and diabetic rats and its mechanisms...
- Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistancePrasad V G Katakam
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Hanes 1050, Medical Center Blvd, Winston Salem, NC 27157, USA
Am J Physiol Regul Integr Comp Physiol 292:R920-6. 2007..Thus obesity accompanied by IR is associated with the inability to precondition against ischemic cardiac injury, which is mediated by enhanced mitochondrial oxidative stress and impaired activation of mitochondrial K(ATP)...
- Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patientsZhiyong Huang
Department of Anesthesia, Sun Yat sen Cardiovascular Hospital, Shenzhen, People s Republic of China
Clin Sci (Lond) 121:57-69. 2011..In conclusion, a joint isoflurane preconditioning and propofol anaesthesia regimen synergistically attenuated myocardial reperfusion injury in patients.
- Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNKHu Xu
Critical Illness Research, Lawson Health Research Institute, 800 Commissioners Road E, VRL Rm A6 138, London, Ontario, Canada
Am J Physiol Heart Circ Physiol 300:H913-21. 2011..Our results indicate that myocyte-derived HMGB1 and TNF-α work in concert to promote I/R-induced myocardial apoptosis through JNK activation...
- Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrestMatthias Thielmann
Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Germany
Basic Res Cardiol 105:657-64. 2010..5% reduction of cTnI (AUC at 72 h). RIPC by repetitive inflation of a cuff around the left upper arm before surgery enhances myocardial protection in patients undergoing CABG surgery with antegrade cold crystalloid cardioplegia...
- Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humansQian Fan
Beijing Chaoyang Hospital Affiliate of Beijing Capital Medical University, Beijing, People s Republic of China
Clin Sci (Lond) 120:251-61. 2011..In conclusion, reduction in ONOO--induced nitro-oxidative stress subsequent to the inhibition of iNOS represents a major mechanism whereby postcon confers cardioprotection in vivo...
- Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signalingJacob Raphael
Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA
J Cardiovasc Pharmacol 55:348-57. 2010..This was also blocked by hyperglycemia. Our results suggest that hyperglycemia inhibits cardioprotection provided by isoflurane postconditioning. This effect seems to be mediated via modulation Akt and eNOS...
- The role of the mitochondrial permeability transition pore in heart diseaseAndrew P Halestrap
Department of Biochemistry and Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Biochim Biophys Acta 1787:1402-15. 2009..This confirms the mPTP as a promising drug target in human cardiovascular disease. Indeed, the first clinical trials have shown CsA treatment improves recovery after treatment of a coronary thrombosis with angioplasty...
- Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failureE J Lesnefsky
Division of Cardiology, Case Western Reserve University and Geriatric Research, Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
J Mol Cell Cardiol 33:1065-89. 2001..Finally, the involvement of mitochondria in the pathogenesis of specific cardiac disease states (ischemia, reperfusion, aging, ischemic preconditioning, and cardiomyopathy) is addressed...
- The myocardial JAK/STAT pathway: from protection to failureKerstin Boengler
Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
Pharmacol Ther 120:172-85. 2008..Furthermore, the requirements for the use of STAT3 as a target for treatment strategies of cardiovascular diseases is discussed...
- Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytesAnne Hamacher-Brady
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 281:29776-87. 2006....
- Myocardial protection at a crossroads: the need for translation into clinical therapyRoberto Bolli
Heart Research Program, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892, USA
Circ Res 95:125-34. 2004....
- MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20Xiao Ping Ren
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
Circulation 119:2357-66. 2009..However, the signature of miRNA expression and possible roles of miRNA in the ischemic heart have been less well studied...
- Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusionGabriel Loor
Department of Surgery, University of Chicago, Chicago, IL 60637, USA
Biochim Biophys Acta 1813:1382-94. 2011..Therefore, mitochondrial apoptosis appears to represent a redundant death pathway in this model of simulated I/R. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
- Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measuresShoji Sanada
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Am J Physiol Heart Circ Physiol 301:H1723-41. 2011..We also review emerging translational clinical trials and the subsistent clinical comorbidities that need to be overcome to make these trials applicable in clinical medicine...
- PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathwayAliaksandr A Bulhak
Division of Cardiology, Department of Medicine, The Rolf Luft Center for Diabetes Research, Karolinska University Hospital, Solna, S 171 76 Stockholm, Sweden
Am J Physiol Heart Circ Physiol 296:H719-27. 2009..05). The results suggest that PPAR-alpha activation protects the type 2 diabetic rat myocardium against ischemia-reperfusion injury via the activation of the PI3K/Akt and NO pathway...
- Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stressLele Ji
Dept of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
Am J Physiol Endocrinol Metab 298:E871-80. 2010..These results provide important novel information on the mechanisms of cardiovascular actions of insulin...
- The mitochondrial permeability transition pore as a target for preconditioning and postconditioningDerek J Hausenloy
The Hatter Institute and Center for Cardiology, University College London Hospitals and Medical School, Grafton Way, London, UK
Basic Res Cardiol 104:189-202. 2009..supporting the mitochondrial permeability transition pore (mPTP) as a major mediator of lethal myocardial reperfusion injury and therefore a critical target for cardioprotection is persuasive...
- The role of autophagy in the heartK Nishida
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Cell Death Differ 16:31-8. 2009..In this review, we will summarize the role of autophagy in the heart under both normal conditions and in response to stress...
- High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptorGregor Theilmeier
Institute for Anatomy, Department of Anesthesiology and Intensive Care, University Hospital Munster, Vesaliusweg 2 4, 48149 Munster, Germany
Circulation 114:1403-9. 2006..We hypothesized that some of the cholesterol transport-independent biological properties of high-density lipoprotein (HDL) implied in atheroprotection may also be beneficial in settings of acute myocardial reperfusion injury.
- Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotectionDerek J Hausenloy
The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London, UK
Heart Fail Rev 12:217-34. 2007....
- Survivin: a novel player in insulin cardioprotection against myocardial ischemia/reperfusion injuryRui Si
Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
J Mol Cell Cardiol 50:16-24. 2011..Taken together, these results suggest a novel role of PI3K/Akt/mTOR/SVV signaling in the cardioprotective effect of insulin...
- Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injuryDenise Hilfiker-Kleiner
Department of Cardiology, Medical School Hannover, Germany
Circ Res 95:187-95. 2004....
- Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehydeHeng Ma
Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
Eur Heart J 32:1025-38. 2011..The present study was designed to examine the mechanism involved in mitochondrial aldehyde dehydrogenase (ALDH2)-induced cardioprotection against ischaemia/reperfusion (I/R) injury with a focus on autophagy...
- Status of myocardial antioxidants in ischemia-reperfusion injuryN S Dhalla
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, 351 Tache Ave, Manitoba, R2H 2A6, Winnipeg, Canada
Cardiovasc Res 47:446-56. 2000..These changes are considered to be the consequence of imbalance between the formation of oxidants and the availability of endogenous antioxidants in the heart...
- Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibitionBenjamin Drenger
Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Anesthesiology 114:1364-72. 2011..To determine whether postC cardioprotection can be restored by normoglycemia, we treated rats with insulin...
- Time to take myocardial reperfusion injury seriouslyDerek J Hausenloy
N Engl J Med 359:518-20. 2008
- Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusionLaura Calvillo
Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan, Italy
J Cardiovasc Pharmacol 58:500-7. 2011..The vagally mediated modulation of inflammatory responses may prove valuable in the clinical management of acute coronary syndromes and of heart failure...
- Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusionClara Di Filippo
Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Italy
Diabetes 54:803-10. 2005..This recovered the huge number of infiltrated polymorphonuclear (PMN) leukocytes within the cardiac tissue associated with the STZ hyperglycemic state and I/R damage...
- N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic ratsTingting Wang
Department of Anaesthesiology, The University of Hong Kong, Hong Kong SAR, China
PLoS ONE 6:e23967. 2011..It is unknown whether or not antioxidant treatment with N-acetylcysteine (NAC) and/or allopurinol (ALP) can attenuate APN deficiency and myocardial ischemia reperfusion (MI/R) injury in the early stage of diabetes...
- Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivoT Matsui
Program in Cardiovascular Gene Therapy, CVRC, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Circulation 104:330-5. 2001..Akt may represent an important nodal target for therapy in ischemic and other heart disease...
- Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic miceS F Yet
Cardiovascular and Pulmonary and Critical Care, Division and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Circ Res 89:168-73. 2001..Our data demonstrate that overexpression of HO-1 in the cardiomyocyte protects against ischemia and reperfusion injury, thus improving the recovery of cardiac function...
- Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanismTuanzhu Ha
Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, PO Box 70575, TN 37614 0575, USA
Cardiovasc Res 78:546-53. 2008..We hypothesized that activation of PI3K/Akt signalling plays a critical role in LPS-induced cardioprotection...
- Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic ratsY Zhang
Department of Cardiovascular Medicine, Fourth Military Medical University, Xi an, Shaanxi 710032, China
Diabetes Obes Metab 12:316-22. 2010....
- Cardioprotection: a radical view Free radicals in pre and postconditioningClaudia Penna
Dipartimento di Scienze Cliniche e Biologiche Università di Torino, Italy Istituto Nazionale Ricerche Cardiovascolari, Bologna, Italy
Biochim Biophys Acta 1787:781-93. 2009..Therefore, our and others' results suggest that the role of ROS in reperfusion may be reconsidered as they are not only deleterious...
- Myocardial reperfusion injury: looking beyond primary PCIGeorg M Fröhlich
The Heart Hospital, University College London Hospitals, 16 18 Westmoreland Street, W1G 8PH, London, UK
Eur Heart J 34:1714-22. 2013..of myocardial reperfusion can itself induce cardiomyocyte death-a phenomenon which has been termed 'myocardial reperfusion injury' (RI), the irreversible consequences of which include microvascular obstruction and myocardial ..
- The role of mitochondria in protection of the heart by preconditioningAndrew P Halestrap
Department of Biochemistry and Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Biochim Biophys Acta 1767:1007-31. 2007..This phase of protection may involve survival kinase pathways such as Akt and glycogen synthase kinase 3 (GSK3) either increasing ROS removal or reducing mitochondrial ROS production...
- Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioningYasuo M Tsutsumi
Department of Anesthesiology, University of California, San Diego, La Jolla, USA
Circulation 118:1979-88. 2008..We hypothesized that cardiac myocyte-specific overexpression of Cav-3 would enhance the formation of caveolae and augment cardiac protection in vivo...
- Ischemic preconditioning protects by activating prosurvival kinases at reperfusionDerek J Hausenloy
The Hatter Institute, University College London Hospital, London, United Kingdom
Am J Physiol Heart Circ Physiol 288:H971-6. 2005..Specifically, we demonstrate that IPC protects the heart by phosphorylating the prosurvival kinases Akt and ERK-1/2 at reperfusion...
- Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptorsF Kerendi
Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, 550 Peachtree Street, Atlanta, GA 30308, USA
Basic Res Cardiol 100:404-12. 2005....
- Myocardial ischemia and reperfusion injuryL Maximilian Buja
Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Cardiovasc Pathol 14:170-5. 2005..Ongoing research into the mechanisms involved in reperfusion and preconditioning is yielding new insights into basic myocardial pathobiology...
- [Limb ischemic preconditioning reduces infarct size following myocardial ischemia-reperfusion in rats]Jing Hui Dong
Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China
Sheng Li Xue Bao 56:41-6. 2004....
- Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-Holger Thiele
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
J Am Coll Cardiol 55:2201-9. 2010....
- The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioningDerek J Hausenloy
The Hatter Institute and Centre for Cardiology, University College London Hospital, WC1E 6DB London, UK
Trends Cardiovasc Med 15:69-75. 2005....
- Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injuryLaurent Argaud
INSERM E 0226, Laboratoire de Physiologie Lyon Nord, Faculté de Médecine Lyon Nord, Universite Claude Bernard Lyon I, 8, avenue Rockefeller, 69373 Lyon Cedex 8, France
J Mol Cell Cardiol 38:367-74. 2005..These data indicate that specific inhibition of MPT pore opening at reperfusion following acute myocardial infarction provides a powerful antinecrotic and antiapoptotic protection...
- Fundamentals of reperfusion injury for the clinical cardiologistSubodh Verma
Division of Cardiac Surgery, University of Toronto, Toronto, Canada
Circulation 105:2332-6. 2002
- Long-term benefit of postconditioningHelene Thibault
Hospices Civils de Lyon, Universite Claude Bernard Lyon 1, Lyon, France
Circulation 117:1037-44. 2008..Our objective was to determine whether ischemic postconditioning could afford (1) a persistent infarct size limitation and (2) an improved recovery of myocardial contractile function several months after infarction...
- Mechanism of cardioprotection by early ischemic preconditioningXiulan Yang
Department of Physiology, College of Medicine, University of South Alabama, MSB 3074, Mobile, AL 36688, USA
Cardiovasc Drugs Ther 24:225-34. 2010..Herein we review the evidence for the above mechanisms and their functional details...
- Mitochondria and ischemia-reperfusion injury of the heart: fixing a holeFabio Di Lisa
Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo 3, 35121 Padova
Cardiovasc Res 70:191-9. 2006..Here, we discuss our current understanding of the structure and function of PTP in the context of heart injury caused by ischemia and reperfusion...
- Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob miceOmar Bouhidel
Institut National de la Santé et de la Recherche Médicale U841, Equipe 3, Universite Paris 12, Creteil, France
Am J Physiol Heart Circ Physiol 295:H1580-6. 2008..The lack of enhanced phosphorylation by IPCD of Akt, ERK1/2, p70S6K1, and AMPK might partly explain the loss of cardioprotection in this experimental model of obese mice...
- Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axisXiaofeng Hu
Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40202, USA
Circulation 116:654-63. 2007..However, the role of the SDF-1alpha-CXCR4 axis in modulating myocardial ischemia/reperfusion injury is unknown...
- Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?Sandrine Lecour
Cardioprotection Group, Hatter Cardiovascular Research Institute, Department of Medicine, Chris Barnard Building, Faculty of Health Sciences, University of Cape Town, 7925 Observatory, South Africa
J Mol Cell Cardiol 47:32-40. 2009..Emerging knowledge on this novel protective path is presented here with the aim of unravelling its interaction with the RISK pathway and its potential human application to protect against lethal reperfusion injury...
- Protective ischaemia in patients: preconditioning and postconditioningAsger Granfeldt
Department of Anesthesiology and Critical Care, Aarhus University, Aarhus, Denmark
Cardiovasc Res 83:234-46. 2009..This review will summarize the physiological preclinical data on preconditioning and Postcon that are relevant to their translation to clinical therapeutics and treatment...
- Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapyAslan T Turer
Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Am J Cardiol 106:360-8. 2010....
- Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibitionAntje Hönisch
Department of Medicine and Cardiology, Heart Center Dresden University Hospital, University of Technology Dresden, Fetscherstr 74, 01307 Dresden, Germany
Basic Res Cardiol 105:155-67. 2010..Whether the reduction of mortality in cardiogenic shock by levosimendan may in part be based on this postconditioning effect remains to be elucidated in clinical setting...
- Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heartSteffen Bohl
Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Am J Physiol Heart Circ Physiol 297:H2054-8. 2009..We have tested published approaches and challenged their practicality. As a result, we propose an improved and streamlined protocol, which consistently yields high-quality histology, thereby minimizing experimental noise and group sizes...
- Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signalingW Keith Jones
Department of Pharmacology and Cell Biophysics, University of Cincinnati, OH 45267 0575, USA
Circulation 120:S1-9. 2009..We previously described a remote cardioprotective effect of nonischemic surgical trauma (abdominal incision) called remote preconditioning of trauma (RPCT). In the present study, we elucidate mechanisms underlying this phenomenon...
- Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitriteKrisztina Kupai
Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
Am J Physiol Heart Circ Physiol 297:H1729-35. 2009..Furthermore, hyperlipidemia blocks the cardioprotective effect of postconditioning at least in part via deterioration of the postconditioning-induced early increase in peroxynitrite formation...
- Anthocyanins from soybean seed coat inhibit the expression of TNF-alpha-induced genes associated with ischemia/reperfusion in endothelial cell by NF-kappaB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivoHye Jung Kim
Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang National University, Republic of Korea
FEBS Lett 580:1391-7. 2006..Further, anthocyanins protected myocardiac injury from I/R in rats. It is suggested that anthocyanins from black soybean seed coat can be used as a useful drug to modulate cardiovascular disorder...
- High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channelsTaiga Ichinomiya
Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan
Cardiovasc Diabetol 11:28. 2012....
- Oxidative injury induces selective rather than global inhibition of proteasomal activityNarasimman Gurusamy
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1110, USA
J Mol Cell Cardiol 44:419-28. 2008..This study gives further insight into interrelationship between oxidative injury and catalytic function of the proteasome in heart, where oxidative injury causes selective rather than global inhibition of proteasome...
- Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat heartsR Arthur Bouwman
Department of Anesthesiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center VUmc, Amsterdam, The Netherlands
Eur J Pharmacol 647:132-8. 2010..Infarct size was reduced in the sevoflurane and bupivacaine-sevoflurane groups (Sevo: 23±7% and Bupi-Sevo: 23±5% vs...
- Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1R A Kloner
Heart Institute, Good Samaritan Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90017, USA
Circulation 104:2981-9. 2001..The future challenge is how to minimize the stunning phenomenon and maximize the preconditioning phenomenon in clinical practice...
- Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injuryStefano Toldo
VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
J Mol Cell Cardiol 51:244-51. 2011..In conclusion, exogenous administration of clinical grade AAT reduces caspase-1 activity in the ischemic myocardium leading to preservation of viable myocardium and prevention of adverse cardiac remodeling...
- Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitusTao Rui
Department of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, China
Cardiovasc Res 94:370-8. 2012..The aims of this study were to test whether diabetes mellitus (DM) affects myocardial levels of IL-33 and to examine whether reduction in IL-33 is responsible for exaggerated I/R injury in the diabetic myocardium...
- Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injuryYiru Guo
Institute of Molecular Cardiology, University of Louisville, 550 S Jackson Street ACB Bldg, 3rd Floor, Louisville, KY 40202, USA
Basic Res Cardiol 107:253. 2012..The results support heretofore unknown differential actions of iNOS depending on cell source and have important translational implications...
- Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injurySuresh Varma Penumathsa
Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
Biochim Biophys Acta 1792:39-48. 2009....
- Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heartDavid A Brown
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
J Appl Physiol 95:2510-8. 2003..05 for both isoforms). Our data indicate that long-term exercise training leads to infarct sparing and better maintenance of coronary flow and mechanical function after ischemia-reperfusion...
- Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioningDonald A Vessey
Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Oxid Med Cell Longev 2:146-51. 2009..In conclusion, POST was less affected by aging than PC; and sphingosine is a uniquely effective agent for both PC and POST of aging hearts...
- Myocardial Salvage With a Novel Reperfusion TherapyCONSTANCE WILSON; Fiscal Year: 2005..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury. A major portion of this injury is due to reperfusion and inflammation of the myocardium and may ..
- PLD2, as a GEF or as a Lipase, is Central to Leukocyte ChemotaxisJULIAN G CAMBRONERO; Fiscal Year: 2013..If we can avoid the untimely presence of these cells in ischemia, heart failure after myocardial infarction would then be diminished. ..
- Mechanisms of photobiomodulation in myocardial reperfusion injuryMartin Bienengraeber; Fiscal Year: 2013..Importantly, the use of NIR for reperfusion injury has the potential for rapid translation to the clinic given its relatively safe profile. ..
- Peroxynitrite in Cardiac Ischemia/ReperfusionXin Liang Ma; Fiscal Year: 2010..myocardial apoptosis after MI/R, and to search for the optimal therapeutic strategies that will reduce myocardial reperfusion injury. The overall hypothesis to be tested in the present grant application is that thioredoxin/thioredoxin ..
- REPERFUSION INJURY AND THE LECTIN COMPLEMENT PATHWAYCHARLES COLLARD; Fiscal Year: 2001..adhesion molecules (ICAM-1); and 3) in vivo inhibition of the lectin complement pathway attenuates myocardial reperfusion injury. Experimental techniques to be used in this proposal include ELISA, flow cytometry, protein affinity ..
- ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSIONJohn Murray; Fiscal Year: 1993..These studies will provide important information regarding the role of ENDOTHELIN in myocardial reperfusion injury and whether modulation of this peptide accounts for the beneficial effects of ADENOSINE on myocardial ..
- MECHANISMS OF MYOCARDIAL REPERFUSION INJURYMERVYN FORMAN; Fiscal Year: 1991..These studies will provide important information regarding the mechanisms of reperfusion injury in the canine model and the usefullness of various agents to limit this entity...
- HUMAN N FORMYL PEPTIDE RECEPTOR--REGULATION AND GENETICSDavid Haviland; Fiscal Year: 2000..of many diseases including adult respiratory distress syndrome (ARDS), rheumatoid arthritis, myocardial reperfusion injury, and inflammatory bowel disease...
- PREVENTION OF ORGAN INJURY DURING CARDIOPULMONARY BYPASSDUKE CAMERON; Fiscal Year: 1993..is a potent inhibitor of complement activation produced by recombinant DNA techniques sCR1 reduces myocardial reperfusion injury in animal models...
- PEROXYNITRITE AS MYOCARDIAL PROTECTIVE AGENTSLaszlo Virag; Fiscal Year: 2000..vascular smooth muscle cells, that peroxynitrite, and hydrogen peroxide, potent oxidants produced in myocardial reperfusion injury, trigger a cascade culminating in cellular energetic failure and cell death (necrosis and apoptosis)...
- ULTRAPOTENT PARS INHIBITOR FOR CARDIOPROTECTIONJohn van Duzer; Fiscal Year: 2000..Peroxynitrite, and hydrogen peroxide, potent oxidants produced in myocardial reperfusion injury, trigger a cascade culminating in cellular energetic failure...
- Myicardial injury: role of poly (ADP-ribose) synthetaseCsaba Szabo; Fiscal Year: 2005..studies on the role of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) in the pathogenesis of myocardial reperfusion injury. In the prior funding cycle, we showed that free radical and oxidant induced activation of PARS ..
- Modified Late Infarct Reperfusion to Prevent Post MI CHFRobert Gorman; Fiscal Year: 2006..It is not the central focus of this proposal to explore the mechanism of myocardial reperfusion injury (although the apoptosis studies will provide new information on how this unique form of cell death ..
- SCOR IN ISCHEMIC HEART DISEASELewis Becker; Fiscal Year: 1999..the role of the endothelium in promoting early neutrophil (PMN) targeting and possible PMN- mediated myocardial reperfusion injury. The specific objectives are to determine (1) the role of adhesion between PMNs and endothelium in ..
- MECHANISMS OF NEUTROPHIL-DEPENDENT VASCULAR DAMAGEStephen Weiss; Fiscal Year: 1993..ranging from immune vasculitis and respiratory distress syndromes to atherosclerotic disease and myocardial reperfusion injury. Nonetheless, the ability of pathophysiologic stimuli to mediate neutrophildependent vascular damage ..
- Tissue Factor in Myocardial ReperfusionJakob Vinten Johansen; Fiscal Year: 2006..abstract_text> ..
- Effect of Drugs on Myocardial HypoxiaGarrett Gross; Fiscal Year: 2009..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
- CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONINGMichael Cohen; Fiscal Year: 2006..Finally, I will see if NECA's salvage of myocardium at reperfusion translates into rapid functional benefits. It is hoped that the potential of this new pharmacologic approach can be defined. ..
- Aging, Adenosine and Platelet-Mediated ThrombosisKarin Przyklenk; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Preconditioning Improves Coronary PatencyKarin Przyklenk; Fiscal Year: 2007..The resulting mechanistic insights may, ultimately, be exploited in the future design of novel therapies for the clinical treatment of recurrent thrombosis. ..
- Role of inositol trisphosphate in preconditioningKarin Przyklenk; Fiscal Year: 2004....
- Mesenchymal Stem Cells for Myocardial InfarctionRobert Kloner; Fiscal Year: 2006..abstract_text> ..
- Cytochrome P450 in Reperfusion InjuryRoberta Gottlieb; Fiscal Year: 2007..This proposal identifies cytochrome P450 monooxygenases as a previously underestimated factor in myocardial reperfusion injury, and establishes the basis for a novel therapeutic approach [unreadable] [unreadable]
- Bid-Mediated Cytochrome c Release from MitochondriaRoberta Gottlieb; Fiscal Year: 2007..These studies will elucidate the molecular mechanism by which BH3-only proteins cause the release of cytochrome c from mitochondria. [unreadable] [unreadable]..
- TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATIONDIPAK DAS; Fiscal Year: 2008..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
- PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURYDIPAK DAS; Fiscal Year: 2009....
- Radiation injury to the heartJohn E Baker; Fiscal Year: 2010..1 ..
- MYOCARDIAL PRESERVATION DURING ISCHEMIC ARRESTDIPAK DAS; Fiscal Year: 2009..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
- CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIAJohn E Baker; Fiscal Year: 2010..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
- Poly (ADP-Ribose) synthetase in expression of endotheliaBasilia Zingarelli; Fiscal Year: 2003..inhibition of PARS on endothelial injury and neutrophil accumulation will be studied in a rat model of myocardial reperfusion injury. Furthermore, experiments will be performed in cultured human umbilical vein endothelial cells ..
- Biologic Ventricular Assist DeviceRobert Kloner; Fiscal Year: 2004..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
- MITOCHONDRIAL ROLE IN CASPASE PROCESSING AND ACTIVATIONRoberta Gottlieb; Fiscal Year: 2003..Understanding these fundamental processes in the comparatively simple and easily manipulated system of Jurkat cells and Fas-mediated apoptosis can be readily translated to studies in the heart. ..
- COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSESRobert Kloner; Fiscal Year: 2003....
- GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIAJohn Baker; Fiscal Year: 2003....
- ROLES FOR P38 MAP KINASES IN CARDIAC MYOCYTE GROWTHCHRISTOPHER GLEMBOTSKI; Fiscal Year: 2003..abstract_text> ..
- DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RATDONNA KORZICK; Fiscal Year: 2003..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
- CROSS MODULATION OF EXCITABILITY AND CA IN HEART FAILUREBRIAN O ROURKE; Fiscal Year: 2007..Elucidation of the molecular details of the regulation of cardiac excitation-contraction coupling will help us to fulfill our long term goal of restoring normal contractile function to the failing heart. ..
- The ER Stress Response and ATF6 Activation in the HeartCHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007..The ERSR has gone virtually unstudied in the heart; accordingly, the proposed studies are novel and will enhance our understanding of the ERSR and the roles played by ATF6 alpha and beta in the stressed myocardium. ..
- Effect of Adenosine A2 receptor activation on the mitochondrial death pathwayZhelong Xu; Fiscal Year: 2010....
- ENERGETIC REGULATION OF CARDIAC ION CHANNELSBRIAN O ROURKE; Fiscal Year: 2004..Understanding this important, but heretofore understudied, problem will ultimately lend insight into all aspects of cardiac pathophysiology. ..
- SIGNALING MECHANISMS IN PHARMACOLOGICAL PRECONDITIONINGRAKESH KUKREJA; Fiscal Year: 2004..These studies will help us learn a great deal on the endogenous mechanisms of delayed preconditioning and assist us in developing innovative techniques leading to one of the most effective means of salvaging ischemic myocardium. ..
- MOLECULAR MECHANISMS OF DELAYED PRECONDITIONINGRAKESH KUKREJA; Fiscal Year: 2006..The information obtained from these studies may help us design novel therapies for protection of the heart against I/R injury. ..
- SIGNAL TRANSDUCTION IN MYOCARDIAL ISCHEMIC INJURYRichard Vander Heide; Fiscal Year: 2001..Experimental design will include morphologic, biochemical, and pharmacologic assessment of isolated myocytes subjected to myocardial ischemia. ..
- Cytoskeletal-Based Survival Pathways in MyocardiumRichard Vander Heide; Fiscal Year: 2010....
- MECHANISM(S) OF ALCOHOL-INDUCED LIVER GRAFT FAILUREJohn Lemasters; Fiscal Year: 2005..This work will develop mechanism-based strategies to increase the use of marginal fatty livers for transplantation in the clinic and save lives. ..
- The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.ALISTAIR ANDREW YOUNG; Fiscal Year: 2010..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
- MEASUREMENT OF FREE RADICAL GENERATION IN THE HEARTJAY LOUIS ZWEIER; Fiscal Year: 2010..These experiments will provide new insight into the fundamental mechanisms that trigger ischemic preconditioning and lead to the development of effective pharmacological therapies to protect the heart. ..
- AC6 as therapy for primary pulmonary hypertensionHemal Patel; Fiscal Year: 2004..Understanding this higher order organization may help define new approaches to achieve the desired therapeutic end point of reduced vascular tone through viral mediated delivery of effector genes such as AC6. ..
- TLR4 Signaling in Myocardial Ischemia-Reperfusion InjuryEdward Verrier; Fiscal Year: 2008..Our intention is to focus on the role TLR4 and its signaling pathways in I/R injury to more precisely define therapeutic targets that are specific to myocardial I/R injury. ..
- Mentored Patient-Oriented Research Career Development AwZhenqi Liu; Fiscal Year: 2004....
- Coronary Endothelial Function in HumansAmir Lerman; Fiscal Year: 2006..The success of this program has the potential to further both the research and mentoring endeavors of patient-oriented investigation and mentoring the next generation of patient-oriented researchers. ..
- Mechanisms of cardiovascular dysfunction in diabetesCsaba Szabo; Fiscal Year: 2005..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
- Adenosine-3 agonists for the suppression of arthritisCsaba Szabo; Fiscal Year: 2003..A novel A3 receptor agonist may represent a useful anti-inflammatory adjunct to current therapeutic regimens; funding of the current SBIR Phase II will allow for starting human safety trials in 2 years. ..
- Peroxynitrate neutralizing agents for stroke therapyCsaba Szabo; Fiscal Year: 2003....
- Ultrapotent PARS inhibitor for CNS traumaCsaba Szabo; Fiscal Year: 2003..Estimated worldwide revenues after market entry and maturation (ca. 4 years after FDA approval)=$750 million (annual). ..
- Multi-Well Extracellular Flux AnalyzerJohn Lemasters; Fiscal Year: 2008..The results of those studies could lead to the development of new therapeutic treatments for some of these diseases. [unreadable] [unreadable] [unreadable]..
- Transcriptional Analysis of Pollutant ExposureRalph Shohet; Fiscal Year: 2007..They further anticipate that these insights will enhance our understanding of vascular pathology and potentially direct efforts at reducing the toxicity of combustion exhaust. ..
- MYOCYTE CELL DEATH DURING EARLY AND LATE PHASESZhi qing Zhao; Fiscal Year: 2003..It is expected that this work will provide new directions in research investigating mechanisms underlying myocyte cell death during reperfusion and thus help in therapeutic decision making. ..
- KALLISTATIN IN HYPERTENSIONJulie Chao; Fiscal Year: 2008..abstract_text> ..