myocardial reperfusion injury

Summary

Summary: Damage to the MYOCARDIUM resulting from reperfusion of ischemic areas of the HEART. Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm. Reperfusion can cause EDEMA, injuries to cardiac myocytes (MYOCYTES, CARDIAC) and the conducting tissue with resultant ARRHYTHMIA. Degree of injury depends on the duration and extent of MYOCARDIAL ISCHEMIA before reperfusion, cytosolic calcium overload, and oxygen FREE RADICALS.

Top Publications

  1. ncbi The inflammatory response in myocardial infarction
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Cardiovasc Res 53:31-47. 2002
  2. ncbi Myocardial reperfusion injury
    Derek M Yellon
    Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
    N Engl J Med 357:1121-35. 2007
  3. ncbi Effect of cyclosporine on reperfusion injury in acute myocardial infarction
    Christophe Piot
    Hopital Arnaud de Villeneuve, Montpellier, France
    N Engl J Med 359:473-81. 2008
  4. pmc Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury
    Elizabeth Murphy
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Physiol Rev 88:581-609. 2008
  5. ncbi Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
  6. ncbi Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
    Takashi Nakagawa
    Laboratory of Molecular Genetics, Department of Post Genomics and Diseases, Japan Science and Technology Corporation, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 434:652-8. 2005
  7. ncbi The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion
    Koen Raedschelders
    Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine The University of British Columbia, Vancouver, BC, Canada
    Pharmacol Ther 133:230-55. 2012
  8. ncbi Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning
    Zhi qing Zhao
    Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine 550 Peachtree Street NE, Atlanta, GA 30308 2225, USA
    Am J Physiol Heart Circ Physiol 285:H579-88. 2003
  9. ncbi Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology
    Michel Ovize
    Service d Explorations Fonctionnelles Cardiovasculaires and Inserm U886, Hospices Civils de Lyon, University of Lyon, France
    Cardiovasc Res 87:406-23. 2010
  10. ncbi Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
    Hans Erik Bøtker
    Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark
    Lancet 375:727-34. 2010

Detail Information

Publications260 found, 100 shown here

  1. ncbi The inflammatory response in myocardial infarction
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Cardiovasc Res 53:31-47. 2002
    ..Elucidating the complex interactions and regulatory mechanisms responsible for cardiac repair may allow us to design effective inflammation-related interventions for the treatment of myocardial infarction...
  2. ncbi Myocardial reperfusion injury
    Derek M Yellon
    Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
    N Engl J Med 357:1121-35. 2007
  3. ncbi Effect of cyclosporine on reperfusion injury in acute myocardial infarction
    Christophe Piot
    Hopital Arnaud de Villeneuve, Montpellier, France
    N Engl J Med 359:473-81. 2008
    ..In this pilot trial, we sought to determine whether the administration of cyclosporine at the time of percutaneous coronary intervention (PCI) would limit the size of the infarct during acute myocardial infarction...
  4. pmc Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury
    Elizabeth Murphy
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Physiol Rev 88:581-609. 2008
    ..Preconditioning activates a number of signaling pathways that reduce Ca(2+) overload and reduce activation of the mitochondrial permeability transition pore. The mitochondrial targets of cardioprotective signals are discussed in detail...
  5. ncbi Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
    ....
  6. ncbi Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
    Takashi Nakagawa
    Laboratory of Molecular Genetics, Department of Post Genomics and Diseases, Japan Science and Technology Corporation, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 434:652-8. 2005
    ..In addition, CypD-deficient mice showed a high level of resistance to ischaemia/reperfusion-induced cardiac injury. Our results indicate that the CypD-dependent mPT regulates some forms of necrotic death, but not apoptotic death...
  7. ncbi The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion
    Koen Raedschelders
    Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine The University of British Columbia, Vancouver, BC, Canada
    Pharmacol Ther 133:230-55. 2012
    ..This overview is illustrated with example clinical studies that have attempted to translate these strategies to reduce the severity of ischemia-reperfusion injury during coronary artery bypass grafting surgery...
  8. ncbi Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning
    Zhi qing Zhao
    Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine 550 Peachtree Street NE, Atlanta, GA 30308 2225, USA
    Am J Physiol Heart Circ Physiol 285:H579-88. 2003
    ..Post-con may be clinically applicable in coronary interventions, coronary artery bypass surgery, organ transplantation, and peripheral revascularization where reperfusion injury is expressed...
  9. ncbi Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology
    Michel Ovize
    Service d Explorations Fonctionnelles Cardiovasculaires and Inserm U886, Hospices Civils de Lyon, University of Lyon, France
    Cardiovasc Res 87:406-23. 2010
    ....
  10. ncbi Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
    Hans Erik Bøtker
    Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark
    Lancet 375:727-34. 2010
    ..We tested the hypothesis that remote ischaemic conditioning during evolving ST-elevation myocardial infarction, and done before primary percutaneous coronary intervention, increases myocardial salvage...
  11. pmc Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Antioxid Redox Signal 14:781-90. 2011
    ..We provide novel evidence for a profound-but potentially reversible-diabetes-induced defect in the cardioprotective efficacy of PostC...
  12. ncbi Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protection
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Toronto, Canada
    Clin Sci (Lond) 117:191-200. 2009
    ..This cardioprotection is transferable across species, independent of local neurogenic activity, and requires opioid receptor activation...
  13. pmc AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
    Raymond R Russell
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Clin Invest 114:495-503. 2004
    ..Thus, AMPK is responsible for activation of glucose uptake and glycolysis during low-flow ischemia and plays an important protective role in limiting damage and apoptotic activity associated with ischemia and reperfusion in the heart...
  14. ncbi Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair: a randomized controlled trial
    Ziad A Ali
    Cambridge Cardiovascular Unit, Cambridge University Hospitals NHS Trust, Long Road, Cambridge, CB2 2QQ, UK
    Circulation 116:I98-105. 2007
    ..CONCLUSIONS: In patients undergoing elective open abdominal aortic aneurysm repair, RIPC reduces the incidence of postoperative myocardial injury, myocardial infarction, and renal impairment...
  15. ncbi Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    Amal K Bose
    The Hatter Institute for Cardiovascular Studies, University College London Hospital and Medical School, Grafton Way, London WC1E, UK
    Diabetes 54:146-51. 2005
    ..This protection appears to involve activating multiple prosurvival kinases. This finding may represent a new therapeutic potential for this class of drug currently undergoing clinical trials in the treatment of type 2 diabetes...
  16. ncbi Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis
    Jiajia Fu
    Department of Pharmacology and Toxicology, Sun Yat Sen University, Guangzhou, 510080, PR China
    Eur J Pharmacol 568:213-21. 2007
    ..The in vivo protection is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio...
  17. ncbi Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heart
    David P Sonne
    Department of Biomedical Sciences and The Danish National Research, Foundation Centre for Heart Arrhythmia, University of Copenhagen, The Panum Institute 12 5, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Regul Pept 146:243-9. 2008
    ..The divergent agonist effects of Exe-4 and GLP-1(9-36), along with correspondingly divergent antagonistic efficacy of Exe(9-39), seem consistent with the presence of more than one type of GLP-1 receptor in this system...
  18. ncbi New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway
    Derek J Hausenloy
    The Hatter Institute and Centre for Cardiology, University College London Hospital and Medical School, Grafton Way, London WC1E 6DB, UK
    Cardiovasc Res 61:448-60. 2004
    ....
  19. ncbi Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling
    Nehmat Ghaboura
    Protection et remodelage du myocarde, UPRES EA 3860, Faculte de Medecine, Universite d Angers, Rue Haute de Reculee, 49045 Angers Cedex 1, France
    Basic Res Cardiol 106:147-62. 2011
    ..In conclusion, direct inhibition of GSK-3β may provide an alternative strategy to protect diabetic hearts against I/R injury...
  20. ncbi Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic mice
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Diabetes 53:454-62. 2004
    ..The beneficial role of iNOS in modulating defensive responses against ischemia/reperfusion injury seems to be abolished in diabetic mice...
  21. pmc Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 11:1096-103. 2005
    ..These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms...
  22. ncbi Remote ischaemic preconditioning: underlying mechanisms and clinical application
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London WC1E 6HX, UK
    Cardiovasc Res 79:377-86. 2008
    ..This article reviews the history and evolution of the phenomenon that is RIPC, the potential mechanistic pathways underlying its cardioprotective effect, and its emerging application in the clinical setting...
  23. ncbi Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
    Jakob Vinten-Johansen
    Division of Cardiothoracic Surgery and Department of Physiology, Emory University School of Medicine, Atlanta, GA 30308 2225, USA
    Cardiovasc Res 61:481-97. 2004
    ..In addition, it will discuss the arguments for and against the involvement of neutrophils in responses to ischemia-reperfusion in experimental models, and the failure to translate experimentally successful therapy into clinical practice...
  24. ncbi The role of oxidants and free radicals in reperfusion injury
    Jay L Zweier
    Davis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, 473 W 12th Ave, Columbus, OH 43210, USA
    Cardiovasc Res 70:181-90. 2006
    ..Ischemic preconditioning markedly decreases NO and oxidant generation, and this appears to be an important mechanism contributing to preconditioning-induced myocardial protection...
  25. pmc Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4
    Cristian Dumitrescu
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:15081-6. 2007
    ..Supplementation of BH(4) may therefore be an important therapeutic approach to reverse endothelial dysfunction in postischemic tissues...
  26. pmc MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury
    Xiaohong Wang
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0575, USA
    Circulation 122:1308-18. 2010
    ..Recently, we and others observed that miR-494 was downregulated in murine I/R-injured and human infarcted hearts. However, the functional consequence of miR-494 in response to I/R remains unknown...
  27. pmc Oxidative stress stimulates autophagic flux during ischemia/reperfusion
    Nirmala Hariharan
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ, New Jersey Medical School, New Jersey, USA
    Antioxid Redox Signal 14:2179-90. 2011
    ..These results suggest that oxidative stress plays an important role in mediating autophagy during I/R, and that activation of autophagy through oxidative stress mediates myocardial injury in response to I/R in the mouse heart...
  28. ncbi A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Biochem Soc Trans 38:841-60. 2010
    ..MPTP inhibition also protects against congestive heart failure in hypertensive animal models. Thus the MPTP is a very promising pharmacological target for clinical practice, especially once more specific drugs are developed...
  29. ncbi Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process
    A L Moens
    Department of Cardiology, University of Antwerp, Belgium
    Int J Cardiol 100:179-90. 2005
    ..g. tetrahydrobiopterin). One of such agents could be folic acid. In this review article the authors give an overview of the recent insights concerning pathogenesis and therapeutic possibilities to prevent IR-induced injury...
  30. ncbi Cardioprotection from ischemia/reperfusion injury: basic and translational research
    Tetsuo Minamino
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Circ J 76:1074-82. 2012
    ..In the near future, large, multicenter, randomized, placebo-controlled, clinical trials will be required to determine whether pharmacological and ischemic conditioning can improve the clinical outcomes of patients with IHDs...
  31. ncbi Preconditioning and postconditioning: underlying mechanisms and clinical application
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London, United Kingdom
    Atherosclerosis 204:334-41. 2009
    ..In this article, we provide an overview of 'conditioning' in all its various forms, describe the underlying mechanisms and review the recent clinical application of this emerging cardioprotective strategy...
  32. ncbi New concepts in reactive oxygen species and cardiovascular reperfusion physiology
    Lance B Becker
    Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine MC5068, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cardiovasc Res 61:461-70. 2004
    ....
  33. ncbi α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats
    Nianlin Xie
    Department of Cardiac Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Arch Med Res 42:171-81. 2011
    ..The present study attempted to investigate the effects of ALA intake on MI/R injury in normal and diabetic rats and its mechanisms...
  34. ncbi Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance
    Prasad V G Katakam
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Hanes 1050, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Regul Integr Comp Physiol 292:R920-6. 2007
    ..Thus obesity accompanied by IR is associated with the inability to precondition against ischemic cardiac injury, which is mediated by enhanced mitochondrial oxidative stress and impaired activation of mitochondrial K(ATP)...
  35. ncbi Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients
    Zhiyong Huang
    Department of Anesthesia, Sun Yat sen Cardiovascular Hospital, Shenzhen, People s Republic of China
    Clin Sci (Lond) 121:57-69. 2011
    ..In conclusion, a joint isoflurane preconditioning and propofol anaesthesia regimen synergistically attenuated myocardial reperfusion injury in patients.
  36. pmc Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK
    Hu Xu
    Critical Illness Research, Lawson Health Research Institute, 800 Commissioners Road E, VRL Rm A6 138, London, Ontario, Canada
    Am J Physiol Heart Circ Physiol 300:H913-21. 2011
    ..Our results indicate that myocyte-derived HMGB1 and TNF-α work in concert to promote I/R-induced myocardial apoptosis through JNK activation...
  37. ncbi Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest
    Matthias Thielmann
    Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Germany
    Basic Res Cardiol 105:657-64. 2010
    ..5% reduction of cTnI (AUC at 72 h). RIPC by repetitive inflation of a cuff around the left upper arm before surgery enhances myocardial protection in patients undergoing CABG surgery with antegrade cold crystalloid cardioplegia...
  38. ncbi Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans
    Qian Fan
    Beijing Chaoyang Hospital Affiliate of Beijing Capital Medical University, Beijing, People s Republic of China
    Clin Sci (Lond) 120:251-61. 2011
    ..In conclusion, reduction in ONOO--induced nitro-oxidative stress subsequent to the inhibition of iNOS represents a major mechanism whereby postcon confers cardioprotection in vivo...
  39. ncbi Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling
    Jacob Raphael
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA
    J Cardiovasc Pharmacol 55:348-57. 2010
    ..This was also blocked by hyperglycemia. Our results suggest that hyperglycemia inhibits cardioprotection provided by isoflurane postconditioning. This effect seems to be mediated via modulation Akt and eNOS...
  40. ncbi The role of the mitochondrial permeability transition pore in heart disease
    Andrew P Halestrap
    Department of Biochemistry and Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Biochim Biophys Acta 1787:1402-15. 2009
    ..This confirms the mPTP as a promising drug target in human cardiovascular disease. Indeed, the first clinical trials have shown CsA treatment improves recovery after treatment of a coronary thrombosis with angioplasty...
  41. ncbi Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure
    E J Lesnefsky
    Division of Cardiology, Case Western Reserve University and Geriatric Research, Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Mol Cell Cardiol 33:1065-89. 2001
    ..Finally, the involvement of mitochondria in the pathogenesis of specific cardiac disease states (ischemia, reperfusion, aging, ischemic preconditioning, and cardiomyopathy) is addressed...
  42. ncbi The myocardial JAK/STAT pathway: from protection to failure
    Kerstin Boengler
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
    Pharmacol Ther 120:172-85. 2008
    ..Furthermore, the requirements for the use of STAT3 as a target for treatment strategies of cardiovascular diseases is discussed...
  43. ncbi Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
    Anne Hamacher-Brady
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:29776-87. 2006
    ....
  44. ncbi Myocardial protection at a crossroads: the need for translation into clinical therapy
    Roberto Bolli
    Heart Research Program, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892, USA
    Circ Res 95:125-34. 2004
    ....
  45. pmc MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20
    Xiao Ping Ren
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    Circulation 119:2357-66. 2009
    ..However, the signature of miRNA expression and possible roles of miRNA in the ischemic heart have been less well studied...
  46. pmc Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion
    Gabriel Loor
    Department of Surgery, University of Chicago, Chicago, IL 60637, USA
    Biochim Biophys Acta 1813:1382-94. 2011
    ..Therefore, mitochondrial apoptosis appears to represent a redundant death pathway in this model of simulated I/R. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  47. ncbi Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures
    Shoji Sanada
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Physiol Heart Circ Physiol 301:H1723-41. 2011
    ..We also review emerging translational clinical trials and the subsistent clinical comorbidities that need to be overcome to make these trials applicable in clinical medicine...
  48. ncbi PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway
    Aliaksandr A Bulhak
    Division of Cardiology, Department of Medicine, The Rolf Luft Center for Diabetes Research, Karolinska University Hospital, Solna, S 171 76 Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 296:H719-27. 2009
    ..05). The results suggest that PPAR-alpha activation protects the type 2 diabetic rat myocardium against ischemia-reperfusion injury via the activation of the PI3K/Akt and NO pathway...
  49. ncbi Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
    Lele Ji
    Dept of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Am J Physiol Endocrinol Metab 298:E871-80. 2010
    ..These results provide important novel information on the mechanisms of cardiovascular actions of insulin...
  50. ncbi The mitochondrial permeability transition pore as a target for preconditioning and postconditioning
    Derek J Hausenloy
    The Hatter Institute and Center for Cardiology, University College London Hospitals and Medical School, Grafton Way, London, UK
    Basic Res Cardiol 104:189-202. 2009
    ..supporting the mitochondrial permeability transition pore (mPTP) as a major mediator of lethal myocardial reperfusion injury and therefore a critical target for cardioprotection is persuasive...
  51. ncbi The role of autophagy in the heart
    K Nishida
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cell Death Differ 16:31-8. 2009
    ..In this review, we will summarize the role of autophagy in the heart under both normal conditions and in response to stress...
  52. ncbi High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor
    Gregor Theilmeier
    Institute for Anatomy, Department of Anesthesiology and Intensive Care, University Hospital Munster, Vesaliusweg 2 4, 48149 Munster, Germany
    Circulation 114:1403-9. 2006
    ..We hypothesized that some of the cholesterol transport-independent biological properties of high-density lipoprotein (HDL) implied in atheroprotection may also be beneficial in settings of acute myocardial reperfusion injury.
  53. ncbi Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London, UK
    Heart Fail Rev 12:217-34. 2007
    ....
  54. ncbi Survivin: a novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury
    Rui Si
    Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Mol Cell Cardiol 50:16-24. 2011
    ..Taken together, these results suggest a novel role of PI3K/Akt/mTOR/SVV signaling in the cardioprotective effect of insulin...
  55. ncbi Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury
    Denise Hilfiker-Kleiner
    Department of Cardiology, Medical School Hannover, Germany
    Circ Res 95:187-95. 2004
    ....
  56. pmc Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde
    Heng Ma
    Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    Eur Heart J 32:1025-38. 2011
    ..The present study was designed to examine the mechanism involved in mitochondrial aldehyde dehydrogenase (ALDH2)-induced cardioprotection against ischaemia/reperfusion (I/R) injury with a focus on autophagy...
  57. ncbi Status of myocardial antioxidants in ischemia-reperfusion injury
    N S Dhalla
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, 351 Tache Ave, Manitoba, R2H 2A6, Winnipeg, Canada
    Cardiovasc Res 47:446-56. 2000
    ..These changes are considered to be the consequence of imbalance between the formation of oxidants and the availability of endogenous antioxidants in the heart...
  58. ncbi Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition
    Benjamin Drenger
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Anesthesiology 114:1364-72. 2011
    ..To determine whether postC cardioprotection can be restored by normoglycemia, we treated rats with insulin...
  59. doi Time to take myocardial reperfusion injury seriously
    Derek J Hausenloy
    N Engl J Med 359:518-20. 2008
  60. ncbi Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion
    Laura Calvillo
    Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan, Italy
    J Cardiovasc Pharmacol 58:500-7. 2011
    ..The vagally mediated modulation of inflammatory responses may prove valuable in the clinical management of acute coronary syndromes and of heart failure...
  61. ncbi Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion
    Clara Di Filippo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Italy
    Diabetes 54:803-10. 2005
    ..This recovered the huge number of infiltrated polymorphonuclear (PMN) leukocytes within the cardiac tissue associated with the STZ hyperglycemic state and I/R damage...
  62. pmc N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats
    Tingting Wang
    Department of Anaesthesiology, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e23967. 2011
    ..It is unknown whether or not antioxidant treatment with N-acetylcysteine (NAC) and/or allopurinol (ALP) can attenuate APN deficiency and myocardial ischemia reperfusion (MI/R) injury in the early stage of diabetes...
  63. ncbi Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    T Matsui
    Program in Cardiovascular Gene Therapy, CVRC, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:330-5. 2001
    ..Akt may represent an important nodal target for therapy in ischemic and other heart disease...
  64. ncbi Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice
    S F Yet
    Cardiovascular and Pulmonary and Critical Care, Division and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:168-73. 2001
    ..Our data demonstrate that overexpression of HO-1 in the cardiomyocyte protects against ischemia and reperfusion injury, thus improving the recovery of cardiac function...
  65. ncbi Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, PO Box 70575, TN 37614 0575, USA
    Cardiovasc Res 78:546-53. 2008
    ..We hypothesized that activation of PI3K/Akt signalling plays a critical role in LPS-induced cardioprotection...
  66. ncbi Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats
    Y Zhang
    Department of Cardiovascular Medicine, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Diabetes Obes Metab 12:316-22. 2010
    ....
  67. ncbi Cardioprotection: a radical view Free radicals in pre and postconditioning
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche Università di Torino, Italy Istituto Nazionale Ricerche Cardiovascolari, Bologna, Italy
    Biochim Biophys Acta 1787:781-93. 2009
    ..Therefore, our and others' results suggest that the role of ROS in reperfusion may be reconsidered as they are not only deleterious...
  68. ncbi Myocardial reperfusion injury: looking beyond primary PCI
    Georg M Fröhlich
    The Heart Hospital, University College London Hospitals, 16 18 Westmoreland Street, W1G 8PH, London, UK
    Eur Heart J 34:1714-22. 2013
    ..of myocardial reperfusion can itself induce cardiomyocyte death-a phenomenon which has been termed 'myocardial reperfusion injury' (RI), the irreversible consequences of which include microvascular obstruction and myocardial ..
  69. pmc The role of mitochondria in protection of the heart by preconditioning
    Andrew P Halestrap
    Department of Biochemistry and Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Biochim Biophys Acta 1767:1007-31. 2007
    ..This phase of protection may involve survival kinase pathways such as Akt and glycogen synthase kinase 3 (GSK3) either increasing ROS removal or reducing mitochondrial ROS production...
  70. pmc Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning
    Yasuo M Tsutsumi
    Department of Anesthesiology, University of California, San Diego, La Jolla, USA
    Circulation 118:1979-88. 2008
    ..We hypothesized that cardiac myocyte-specific overexpression of Cav-3 would enhance the formation of caveolae and augment cardiac protection in vivo...
  71. ncbi Ischemic preconditioning protects by activating prosurvival kinases at reperfusion
    Derek J Hausenloy
    The Hatter Institute, University College London Hospital, London, United Kingdom
    Am J Physiol Heart Circ Physiol 288:H971-6. 2005
    ..Specifically, we demonstrate that IPC protects the heart by phosphorylating the prosurvival kinases Akt and ERK-1/2 at reperfusion...
  72. ncbi Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors
    F Kerendi
    Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, 550 Peachtree Street, Atlanta, GA 30308, USA
    Basic Res Cardiol 100:404-12. 2005
    ....
  73. ncbi Myocardial ischemia and reperfusion injury
    L Maximilian Buja
    Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Cardiovasc Pathol 14:170-5. 2005
    ..Ongoing research into the mechanisms involved in reperfusion and preconditioning is yielding new insights into basic myocardial pathobiology...
  74. ncbi [Limb ischemic preconditioning reduces infarct size following myocardial ischemia-reperfusion in rats]
    Jing Hui Dong
    Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China
    Sheng Li Xue Bao 56:41-6. 2004
    ....
  75. ncbi Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 55:2201-9. 2010
    ....
  76. ncbi The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning
    Derek J Hausenloy
    The Hatter Institute and Centre for Cardiology, University College London Hospital, WC1E 6DB London, UK
    Trends Cardiovasc Med 15:69-75. 2005
    ....
  77. ncbi Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury
    Laurent Argaud
    INSERM E 0226, Laboratoire de Physiologie Lyon Nord, Faculté de Médecine Lyon Nord, Universite Claude Bernard Lyon I, 8, avenue Rockefeller, 69373 Lyon Cedex 8, France
    J Mol Cell Cardiol 38:367-74. 2005
    ..These data indicate that specific inhibition of MPT pore opening at reperfusion following acute myocardial infarction provides a powerful antinecrotic and antiapoptotic protection...
  78. ncbi Fundamentals of reperfusion injury for the clinical cardiologist
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Canada
    Circulation 105:2332-6. 2002
  79. ncbi Long-term benefit of postconditioning
    Helene Thibault
    Hospices Civils de Lyon, Universite Claude Bernard Lyon 1, Lyon, France
    Circulation 117:1037-44. 2008
    ..Our objective was to determine whether ischemic postconditioning could afford (1) a persistent infarct size limitation and (2) an improved recovery of myocardial contractile function several months after infarction...
  80. pmc Mechanism of cardioprotection by early ischemic preconditioning
    Xiulan Yang
    Department of Physiology, College of Medicine, University of South Alabama, MSB 3074, Mobile, AL 36688, USA
    Cardiovasc Drugs Ther 24:225-34. 2010
    ..Herein we review the evidence for the above mechanisms and their functional details...
  81. ncbi Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole
    Fabio Di Lisa
    Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo 3, 35121 Padova
    Cardiovasc Res 70:191-9. 2006
    ..Here, we discuss our current understanding of the structure and function of PTP in the context of heart injury caused by ischemia and reperfusion...
  82. pmc Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice
    Omar Bouhidel
    Institut National de la Santé et de la Recherche Médicale U841, Equipe 3, Universite Paris 12, Creteil, France
    Am J Physiol Heart Circ Physiol 295:H1580-6. 2008
    ..The lack of enhanced phosphorylation by IPCD of Akt, ERK1/2, p70S6K1, and AMPK might partly explain the loss of cardioprotection in this experimental model of obese mice...
  83. pmc Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis
    Xiaofeng Hu
    Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40202, USA
    Circulation 116:654-63. 2007
    ..However, the role of the SDF-1alpha-CXCR4 axis in modulating myocardial ischemia/reperfusion injury is unknown...
  84. ncbi Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?
    Sandrine Lecour
    Cardioprotection Group, Hatter Cardiovascular Research Institute, Department of Medicine, Chris Barnard Building, Faculty of Health Sciences, University of Cape Town, 7925 Observatory, South Africa
    J Mol Cell Cardiol 47:32-40. 2009
    ..Emerging knowledge on this novel protective path is presented here with the aim of unravelling its interaction with the RISK pathway and its potential human application to protect against lethal reperfusion injury...
  85. pmc Protective ischaemia in patients: preconditioning and postconditioning
    Asger Granfeldt
    Department of Anesthesiology and Critical Care, Aarhus University, Aarhus, Denmark
    Cardiovasc Res 83:234-46. 2009
    ..This review will summarize the physiological preclinical data on preconditioning and Postcon that are relevant to their translation to clinical therapeutics and treatment...
  86. pmc Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy
    Aslan T Turer
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 106:360-8. 2010
    ....
  87. ncbi Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition
    Antje Hönisch
    Department of Medicine and Cardiology, Heart Center Dresden University Hospital, University of Technology Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Basic Res Cardiol 105:155-67. 2010
    ..Whether the reduction of mortality in cardiogenic shock by levosimendan may in part be based on this postconditioning effect remains to be elucidated in clinical setting...
  88. pmc Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart
    Steffen Bohl
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H2054-8. 2009
    ..We have tested published approaches and challenged their practicality. As a result, we propose an improved and streamlined protocol, which consistently yields high-quality histology, thereby minimizing experimental noise and group sizes...
  89. pmc Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling
    W Keith Jones
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, OH 45267 0575, USA
    Circulation 120:S1-9. 2009
    ..We previously described a remote cardioprotective effect of nonischemic surgical trauma (abdominal incision) called remote preconditioning of trauma (RPCT). In the present study, we elucidate mechanisms underlying this phenomenon...
  90. ncbi Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite
    Krisztina Kupai
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Hungary
    Am J Physiol Heart Circ Physiol 297:H1729-35. 2009
    ..Furthermore, hyperlipidemia blocks the cardioprotective effect of postconditioning at least in part via deterioration of the postconditioning-induced early increase in peroxynitrite formation...
  91. ncbi Anthocyanins from soybean seed coat inhibit the expression of TNF-alpha-induced genes associated with ischemia/reperfusion in endothelial cell by NF-kappaB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo
    Hye Jung Kim
    Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang National University, Republic of Korea
    FEBS Lett 580:1391-7. 2006
    ..Further, anthocyanins protected myocardiac injury from I/R in rats. It is suggested that anthocyanins from black soybean seed coat can be used as a useful drug to modulate cardiovascular disorder...
  92. pmc High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels
    Taiga Ichinomiya
    Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan
    Cardiovasc Diabetol 11:28. 2012
    ....
  93. ncbi Oxidative injury induces selective rather than global inhibition of proteasomal activity
    Narasimman Gurusamy
    Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1110, USA
    J Mol Cell Cardiol 44:419-28. 2008
    ..This study gives further insight into interrelationship between oxidative injury and catalytic function of the proteasome in heart, where oxidative injury causes selective rather than global inhibition of proteasome...
  94. ncbi Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts
    R Arthur Bouwman
    Department of Anesthesiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center VUmc, Amsterdam, The Netherlands
    Eur J Pharmacol 647:132-8. 2010
    ..Infarct size was reduced in the sevoflurane and bupivacaine-sevoflurane groups (Sevo: 23±7% and Bupi-Sevo: 23±5% vs...
  95. ncbi Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1
    R A Kloner
    Heart Institute, Good Samaritan Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90017, USA
    Circulation 104:2981-9. 2001
    ..The future challenge is how to minimize the stunning phenomenon and maximize the preconditioning phenomenon in clinical practice...
  96. ncbi Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
    J Mol Cell Cardiol 51:244-51. 2011
    ..In conclusion, exogenous administration of clinical grade AAT reduces caspase-1 activity in the ischemic myocardium leading to preservation of viable myocardium and prevention of adverse cardiac remodeling...
  97. ncbi Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitus
    Tao Rui
    Department of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, China
    Cardiovasc Res 94:370-8. 2012
    ..The aims of this study were to test whether diabetes mellitus (DM) affects myocardial levels of IL-33 and to examine whether reduction in IL-33 is responsible for exaggerated I/R injury in the diabetic myocardium...
  98. pmc Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury
    Yiru Guo
    Institute of Molecular Cardiology, University of Louisville, 550 S Jackson Street ACB Bldg, 3rd Floor, Louisville, KY 40202, USA
    Basic Res Cardiol 107:253. 2012
    ..The results support heretofore unknown differential actions of iNOS depending on cell source and have important translational implications...
  99. ncbi Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injury
    Suresh Varma Penumathsa
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
    Biochim Biophys Acta 1792:39-48. 2009
    ....
  100. ncbi Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart
    David A Brown
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    J Appl Physiol 95:2510-8. 2003
    ..05 for both isoforms). Our data indicate that long-term exercise training leads to infarct sparing and better maintenance of coronary flow and mechanical function after ischemia-reperfusion...
  101. pmc Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning
    Donald A Vessey
    Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Oxid Med Cell Longev 2:146-51. 2009
    ..In conclusion, POST was less affected by aging than PC; and sphingosine is a uniquely effective agent for both PC and POST of aging hearts...

Research Grants63

  1. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..S. annually. Prolonged ischemia of the heart followed by reperfusion produces myocardial reperfusion injury. A major portion of this injury is due to reperfusion and inflammation of the myocardium and may ..
  2. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..If we can avoid the untimely presence of these cells in ischemia, heart failure after myocardial infarction would then be diminished. ..
  3. Mechanisms of photobiomodulation in myocardial reperfusion injury
    Martin Bienengraeber; Fiscal Year: 2013
    ..Importantly, the use of NIR for reperfusion injury has the potential for rapid translation to the clinic given its relatively safe profile. ..
  4. Peroxynitrite in Cardiac Ischemia/Reperfusion
    Xin Liang Ma; Fiscal Year: 2010
    ..myocardial apoptosis after MI/R, and to search for the optimal therapeutic strategies that will reduce myocardial reperfusion injury. The overall hypothesis to be tested in the present grant application is that thioredoxin/thioredoxin ..
  5. REPERFUSION INJURY AND THE LECTIN COMPLEMENT PATHWAY
    CHARLES COLLARD; Fiscal Year: 2001
    ..adhesion molecules (ICAM-1); and 3) in vivo inhibition of the lectin complement pathway attenuates myocardial reperfusion injury. Experimental techniques to be used in this proposal include ELISA, flow cytometry, protein affinity ..
  6. ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSION
    John Murray; Fiscal Year: 1993
    ..These studies will provide important information regarding the role of ENDOTHELIN in myocardial reperfusion injury and whether modulation of this peptide accounts for the beneficial effects of ADENOSINE on myocardial ..
  7. MECHANISMS OF MYOCARDIAL REPERFUSION INJURY
    MERVYN FORMAN; Fiscal Year: 1991
    ..These studies will provide important information regarding the mechanisms of reperfusion injury in the canine model and the usefullness of various agents to limit this entity...
  8. HUMAN N FORMYL PEPTIDE RECEPTOR--REGULATION AND GENETICS
    David Haviland; Fiscal Year: 2000
    ..of many diseases including adult respiratory distress syndrome (ARDS), rheumatoid arthritis, myocardial reperfusion injury, and inflammatory bowel disease...
  9. PREVENTION OF ORGAN INJURY DURING CARDIOPULMONARY BYPASS
    DUKE CAMERON; Fiscal Year: 1993
    ..is a potent inhibitor of complement activation produced by recombinant DNA techniques sCR1 reduces myocardial reperfusion injury in animal models...
  10. PEROXYNITRITE AS MYOCARDIAL PROTECTIVE AGENTS
    Laszlo Virag; Fiscal Year: 2000
    ..vascular smooth muscle cells, that peroxynitrite, and hydrogen peroxide, potent oxidants produced in myocardial reperfusion injury, trigger a cascade culminating in cellular energetic failure and cell death (necrosis and apoptosis)...
  11. ULTRAPOTENT PARS INHIBITOR FOR CARDIOPROTECTION
    John van Duzer; Fiscal Year: 2000
    ..Peroxynitrite, and hydrogen peroxide, potent oxidants produced in myocardial reperfusion injury, trigger a cascade culminating in cellular energetic failure...
  12. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2005
    ..studies on the role of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) in the pathogenesis of myocardial reperfusion injury. In the prior funding cycle, we showed that free radical and oxidant induced activation of PARS ..
  13. Modified Late Infarct Reperfusion to Prevent Post MI CHF
    Robert Gorman; Fiscal Year: 2006
    ..It is not the central focus of this proposal to explore the mechanism of myocardial reperfusion injury (although the apoptosis studies will provide new information on how this unique form of cell death ..
  14. SCOR IN ISCHEMIC HEART DISEASE
    Lewis Becker; Fiscal Year: 1999
    ..the role of the endothelium in promoting early neutrophil (PMN) targeting and possible PMN- mediated myocardial reperfusion injury. The specific objectives are to determine (1) the role of adhesion between PMNs and endothelium in ..
  15. MECHANISMS OF NEUTROPHIL-DEPENDENT VASCULAR DAMAGE
    Stephen Weiss; Fiscal Year: 1993
    ..ranging from immune vasculitis and respiratory distress syndromes to atherosclerotic disease and myocardial reperfusion injury. Nonetheless, the ability of pathophysiologic stimuli to mediate neutrophildependent vascular damage ..
  16. Tissue Factor in Myocardial Reperfusion
    Jakob Vinten Johansen; Fiscal Year: 2006
    ..abstract_text> ..
  17. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  18. CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
    Michael Cohen; Fiscal Year: 2006
    ..Finally, I will see if NECA's salvage of myocardium at reperfusion translates into rapid functional benefits. It is hoped that the potential of this new pharmacologic approach can be defined. ..
  19. Aging, Adenosine and Platelet-Mediated Thrombosis
    Karin Przyklenk; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Preconditioning Improves Coronary Patency
    Karin Przyklenk; Fiscal Year: 2007
    ..The resulting mechanistic insights may, ultimately, be exploited in the future design of novel therapies for the clinical treatment of recurrent thrombosis. ..
  21. Role of inositol trisphosphate in preconditioning
    Karin Przyklenk; Fiscal Year: 2004
    ....
  22. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  23. Cytochrome P450 in Reperfusion Injury
    Roberta Gottlieb; Fiscal Year: 2007
    ..This proposal identifies cytochrome P450 monooxygenases as a previously underestimated factor in myocardial reperfusion injury, and establishes the basis for a novel therapeutic approach [unreadable] [unreadable]
  24. Bid-Mediated Cytochrome c Release from Mitochondria
    Roberta Gottlieb; Fiscal Year: 2007
    ..These studies will elucidate the molecular mechanism by which BH3-only proteins cause the release of cytochrome c from mitochondria. [unreadable] [unreadable]..
  25. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2008
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
  26. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....
  27. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010
    ..1 ..
  28. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  29. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  30. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..inhibition of PARS on endothelial injury and neutrophil accumulation will be studied in a rat model of myocardial reperfusion injury. Furthermore, experiments will be performed in cultured human umbilical vein endothelial cells ..
  31. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  32. MITOCHONDRIAL ROLE IN CASPASE PROCESSING AND ACTIVATION
    Roberta Gottlieb; Fiscal Year: 2003
    ..Understanding these fundamental processes in the comparatively simple and easily manipulated system of Jurkat cells and Fas-mediated apoptosis can be readily translated to studies in the heart. ..
  33. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  34. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
    ....
  35. ROLES FOR P38 MAP KINASES IN CARDIAC MYOCYTE GROWTH
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2003
    ..abstract_text> ..
  36. DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RAT
    DONNA KORZICK; Fiscal Year: 2003
    ..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
  37. CROSS MODULATION OF EXCITABILITY AND CA IN HEART FAILURE
    BRIAN O ROURKE; Fiscal Year: 2007
    ..Elucidation of the molecular details of the regulation of cardiac excitation-contraction coupling will help us to fulfill our long term goal of restoring normal contractile function to the failing heart. ..
  38. The ER Stress Response and ATF6 Activation in the Heart
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007
    ..The ERSR has gone virtually unstudied in the heart; accordingly, the proposed studies are novel and will enhance our understanding of the ERSR and the roles played by ATF6 alpha and beta in the stressed myocardium. ..
  39. Effect of Adenosine A2 receptor activation on the mitochondrial death pathway
    Zhelong Xu; Fiscal Year: 2010
    ....
  40. ENERGETIC REGULATION OF CARDIAC ION CHANNELS
    BRIAN O ROURKE; Fiscal Year: 2004
    ..Understanding this important, but heretofore understudied, problem will ultimately lend insight into all aspects of cardiac pathophysiology. ..
  41. SIGNALING MECHANISMS IN PHARMACOLOGICAL PRECONDITIONING
    RAKESH KUKREJA; Fiscal Year: 2004
    ..These studies will help us learn a great deal on the endogenous mechanisms of delayed preconditioning and assist us in developing innovative techniques leading to one of the most effective means of salvaging ischemic myocardium. ..
  42. MOLECULAR MECHANISMS OF DELAYED PRECONDITIONING
    RAKESH KUKREJA; Fiscal Year: 2006
    ..The information obtained from these studies may help us design novel therapies for protection of the heart against I/R injury. ..
  43. SIGNAL TRANSDUCTION IN MYOCARDIAL ISCHEMIC INJURY
    Richard Vander Heide; Fiscal Year: 2001
    ..Experimental design will include morphologic, biochemical, and pharmacologic assessment of isolated myocytes subjected to myocardial ischemia. ..
  44. Cytoskeletal-Based Survival Pathways in Myocardium
    Richard Vander Heide; Fiscal Year: 2010
    ....
  45. MECHANISM(S) OF ALCOHOL-INDUCED LIVER GRAFT FAILURE
    John Lemasters; Fiscal Year: 2005
    ..This work will develop mechanism-based strategies to increase the use of marginal fatty livers for transplantation in the clinic and save lives. ..
  46. The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.
    ALISTAIR ANDREW YOUNG; Fiscal Year: 2010
    ..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
  47. MEASUREMENT OF FREE RADICAL GENERATION IN THE HEART
    JAY LOUIS ZWEIER; Fiscal Year: 2010
    ..These experiments will provide new insight into the fundamental mechanisms that trigger ischemic preconditioning and lead to the development of effective pharmacological therapies to protect the heart. ..
  48. AC6 as therapy for primary pulmonary hypertension
    Hemal Patel; Fiscal Year: 2004
    ..Understanding this higher order organization may help define new approaches to achieve the desired therapeutic end point of reduced vascular tone through viral mediated delivery of effector genes such as AC6. ..
  49. TLR4 Signaling in Myocardial Ischemia-Reperfusion Injury
    Edward Verrier; Fiscal Year: 2008
    ..Our intention is to focus on the role TLR4 and its signaling pathways in I/R injury to more precisely define therapeutic targets that are specific to myocardial I/R injury. ..
  50. Mentored Patient-Oriented Research Career Development Aw
    Zhenqi Liu; Fiscal Year: 2004
    ....
  51. Coronary Endothelial Function in Humans
    Amir Lerman; Fiscal Year: 2006
    ..The success of this program has the potential to further both the research and mentoring endeavors of patient-oriented investigation and mentoring the next generation of patient-oriented researchers. ..
  52. Mechanisms of cardiovascular dysfunction in diabetes
    Csaba Szabo; Fiscal Year: 2005
    ..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
  53. Adenosine-3 agonists for the suppression of arthritis
    Csaba Szabo; Fiscal Year: 2003
    ..A novel A3 receptor agonist may represent a useful anti-inflammatory adjunct to current therapeutic regimens; funding of the current SBIR Phase II will allow for starting human safety trials in 2 years. ..
  54. Peroxynitrate neutralizing agents for stroke therapy
    Csaba Szabo; Fiscal Year: 2003
    ....
  55. Ultrapotent PARS inhibitor for CNS trauma
    Csaba Szabo; Fiscal Year: 2003
    ..Estimated worldwide revenues after market entry and maturation (ca. 4 years after FDA approval)=$750 million (annual). ..
  56. Multi-Well Extracellular Flux Analyzer
    John Lemasters; Fiscal Year: 2008
    ..The results of those studies could lead to the development of new therapeutic treatments for some of these diseases. [unreadable] [unreadable] [unreadable]..
  57. Transcriptional Analysis of Pollutant Exposure
    Ralph Shohet; Fiscal Year: 2007
    ..They further anticipate that these insights will enhance our understanding of vascular pathology and potentially direct efforts at reducing the toxicity of combustion exhaust. ..
  58. MYOCYTE CELL DEATH DURING EARLY AND LATE PHASES
    Zhi qing Zhao; Fiscal Year: 2003
    ..It is expected that this work will provide new directions in research investigating mechanisms underlying myocyte cell death during reperfusion and thus help in therapeutic decision making. ..
  59. KALLISTATIN IN HYPERTENSION
    Julie Chao; Fiscal Year: 2008
    ..abstract_text> ..