bradycardia

Summary

Summary: Excessive slowness in the action of the heart, usually with a heart rate below 60 beats per minute.

Top Publications

  1. ncbi Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
    Shahid M Baig
    Human Molecular Genetics Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
    Nat Neurosci 14:77-84. 2011
  2. ncbi Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflex
    S M Kinsella
    Sir Humphry Davy Department of Anaesthesia, St Michael's Hospital, Bristol, UK
    Br J Anaesth 86:859-68. 2001
  3. pmc Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice
    Peiyong Zhai
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Clin Invest 115:3045-56. 2005
  4. ncbi Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors
    John T Fisher
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    FASEB J 18:711-3. 2004
  5. ncbi Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families
    Marieke W Veldkamp
    Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 92:976-83. 2003
  6. pmc Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients
    A V Postma
    J Med Genet 42:863-70. 2005
  7. ncbi Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakers
    Alessandro Capucci
    Cardiology Department, Civile Hospital, Piacenza, Italy
    J Am Coll Cardiol 46:1913-20. 2005
  8. ncbi Pediatric rapid sequence intubation: incidence of reflex bradycardia and effects of pretreatment with atropine
    Rebecca K Fastle
    Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center and The Children s Hospital, Denver, CO, USA
    Pediatr Emerg Care 20:651-5. 2004
  9. ncbi Bradycardia during critical care intubation: mechanisms, significance and atropine
    Peter Jones
    Critical Care Group Portex Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Arch Dis Child 97:139-44. 2012
  10. pmc The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat
    Ryan M Fryer
    Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, United States of America
    PLoS ONE 7:e52985. 2012

Detail Information

Publications355 found, 100 shown here

  1. ncbi Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
    Shahid M Baig
    Human Molecular Genetics Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
    Nat Neurosci 14:77-84. 2011
    ..We describe a human channelopathy (termed SANDD syndrome, sinoatrial node dysfunction and deafness) with a cardiac and auditory phenotype that closely resembles that of Cacna1d(-/-) mice...
  2. ncbi Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflex
    S M Kinsella
    Sir Humphry Davy Department of Anaesthesia, St Michael's Hospital, Bristol, UK
    Br J Anaesth 86:859-68. 2001
    Reflex cardiovascular depression with vasodilation and bradycardia has been variously termed vasovagal syncope, the Bezold-Jarisch reflex and neurocardiogenic syncope...
  3. pmc Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice
    Peiyong Zhai
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Clin Invest 115:3045-56. 2005
    ..Tg-i2m mice developed more severe cardiac hypertrophy and bradycardia coupled with lower cardiac function than Tg-WT mice...
  4. ncbi Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors
    John T Fisher
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    FASEB J 18:711-3. 2004
    ..ligands, have complicated the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due to vagal innervation...
  5. ncbi Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families
    Marieke W Veldkamp
    Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 92:976-83. 2003
    ..In addition to the characteristic QT prolongation, LQT3 carriers regularly present with bradycardia and sinus pauses...
  6. pmc Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients
    A V Postma
    J Med Genet 42:863-70. 2005
    ..The aim of the study was to assess underlying genetic cause(s), clinical features, and response to therapy in catecholaminergic polymorphic ventricular tachycardia (CPVT) probands...
  7. ncbi Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakers
    Alessandro Capucci
    Cardiology Department, Civile Hospital, Piacenza, Italy
    J Am Coll Cardiol 46:1913-20. 2005
    The aim of our study was to evaluate arterial embolism (AE) occurrence rates and predictors in patients suffering from bradycardia and wearing a pacemaker with antitachycardia pacing therapies.
  8. ncbi Pediatric rapid sequence intubation: incidence of reflex bradycardia and effects of pretreatment with atropine
    Rebecca K Fastle
    Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center and The Children s Hospital, Denver, CO, USA
    Pediatr Emerg Care 20:651-5. 2004
    The American College of Emergency Physicians (ACEP) recommends atropine as adjunctive therapy to prevent reflex bradycardia prior to laryngoscopy/tracheal intubation (L/TI) in pediatric patients.
  9. ncbi Bradycardia during critical care intubation: mechanisms, significance and atropine
    Peter Jones
    Critical Care Group Portex Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Arch Dis Child 97:139-44. 2012
    b>Bradycardia occurs during the intubation of some critically ill children as a result of vagal stimulation due to hypoxia and/or laryngeal stimulation; such 'stable' bradycardia is accompanied by selective vasoconstriction...
  10. pmc The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat
    Ryan M Fryer
    Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, United States of America
    PLoS ONE 7:e52985. 2012
    ..S1P(X) receptor agonist) produces modest hypertension in patients (2-3 mmHg in 1-yr trial) as well as acute bradycardia independent of changes in blood pressure...
  11. ncbi Cholinesterase inhibitors and incidence of bradycardia in patients with dementia in the veterans affairs new England healthcare system
    Rohini K Hernandez
    Cooperative Studies Program, Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    J Am Geriatr Soc 57:1997-2003. 2009
    To quantify the association between cholinesterase inhibitors (ChE-Is) and a new diagnosis of bradycardia and to evaluate the clinical significance of bradycardia.
  12. ncbi Prolonged and symptomatic bradycardia following a single dose of fingolimod
    Hans Faber
    Neurology, Max Planck Institute of Psychiatry, Munich, Germany
    Mult Scler 19:126-8. 2013
    Fingolimod-related bradycardia is usually asymptomatic, reaches its nadir within 6 hours post-dose and recovers spontaneously...
  13. ncbi Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia
    Atsunori Kamiya
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1 Hujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 289:H1758-69. 2005
    ..LF oscillation of MSNA variability decreased during development of orthostatic neurally mediated syncope, preceding sympathetic withdrawal, bradycardia, and severe hypotension, to the level at syncope.
  14. ncbi Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia
    Yongxia Qu
    VA New York Harbor Healthcare System, New York, NY, USA
    Circulation 111:3034-41. 2005
    ..Although the hallmark of CHB is complete atrioventricular block, sinus bradycardia has been reported recently in animal models of CHB...
  15. ncbi Mechanism of syncope in patients with isolated syncope and in patients with tilt-positive syncope
    A Moya
    Departments of Cardiology of Hospital Vall d'Hebron, Barcelona, Spain
    Circulation 104:1261-7. 2001
    ..one or more prolonged asystolic pauses, mainly due to sinus arrest, preceded for a few minutes by progressive bradycardia or progressive tachycardia-bradycardia...
  16. pmc Atropine for critical care intubation in a cohort of 264 children and reduced mortality unrelated to effects on bradycardia
    Peter Jones
    Critical Care Group Portex Unit, Institute of Child Health, University College London, London, Great Britain
    PLoS ONE 8:e57478. 2013
    ..Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality...
  17. ncbi Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development
    Rudiger J Blaschke
    Human Genetics, University of Heidelberg, Heidelberg, Germany
    Circulation 115:1830-8. 2007
    ..Here, we report on a highly restricted expression pattern of the homeodomain transcription factor Shox2 in the sinus venosus myocardium, including the sinoatrial nodal region and the venous valves...
  18. ncbi Treatment of persistent sinus bradycardia with intermittent symptoms: are guidelines clear?
    Paolo Alboni
    Division of Cardiology, Arrhythmologic Center, Ospedale Civile di Cento, 44042 Cento FE, Italy
    Europace 11:562-4. 2009
    There is uncertainty in the aetiology of syncope in subjects with persistent sinus bradycardia (SB) (sick sinus syndrome)...
  19. ncbi Role of pulmonary stretch receptors and sympathetic system in the inhibition of reflex bradycardia produced by chemical stimulation of the periaqueductal gray matter of the rat
    K N Sampaio
    Department of Pharmaceutical Sciences, Health Science Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
    Neuroscience 210:222-33. 2012
    ..The baroreflex bradycardia was induced by phenylephrine infusions (PHE, 50 μg/ml/min, i.v...
  20. ncbi The development of diving bradycardia in bottlenose dolphins (Tursiops truncatus)
    S R Noren
    Ecology and Evolutionary Biology Department, Center for Ocean Health, University of California, Santa Cruz, CA 95060, USA
    J Comp Physiol B 174:139-47. 2004
    b>Bradycardia is an important component of the dive response, yet little is known about this response in immature marine mammals...
  21. ncbi Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford University OX1 3PT, UK
    J Mol Cell Cardiol 44:477-85. 2008
    ..Y (NPY), released during prolonged cardiac sympathetic nerve stimulation, can attenuate vagal-induced bradycardia. We tested the hypothesis that NPY reduces acetylcholine release, at similar concentrations to which it ..
  22. ncbi Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes
    Yukiomi Tsuji
    Research Center, Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Circulation 113:345-55. 2006
    ..Uncontrolled tachycardia produces heart failure and ventricular tachyarrhythmia susceptibility, whereas bradycardia promotes spontaneous torsade de pointes (TdP)...
  23. ncbi Bradycardia leading to asystole during dexmedetomidine infusion in an 18 year-old double-lung transplant recipient
    Xiaopeng Zhang
    Division of Anesthesiology, Geisinger Medical Center, Danville, PA 17821, USA
    J Clin Anesth 22:45-9. 2010
    ..transplant recipient recovering from acute respiratory distress syndrome who developed repeated episodes of bradycardia and asystole (maximum duration: 10 sec) during dexmedetomidine administration is presented...
  24. ncbi Hypotension, bradycardia and syncope caused by honey poisoning
    Ozcan Yilmaz
    Ondokuz Mayis University School of Medicine, Department of Cardiology, Kurupelit, Samsun, Turkey
    Resuscitation 68:405-8. 2006
    ..with a variety of symptoms including nausea, vomiting, salivation, dizziness, weakness, hypotension, bradycardia and syncope several hours after the ingestion of small amounts of honey...
  25. ncbi Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia
    Luiza Michelle Cangussu
    Departamento de Ciencias Biologicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil
    Peptides 30:1921-7. 2009
    ..and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C)...
  26. pmc Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibition
    Boyoung Joung
    Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University Schoolof Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Heart Circ Physiol 299:H634-42. 2010
    ..Combined malfunction of both membrane and Ca(2+) clocks underlies the mechanisms of PSPs...
  27. pmc Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4
    Mirko Baruscotti
    Department of Biomolecular Sciences and Biotechnology, PaceLab and Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata, Milano, Universita degli Studi di Milano, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 108:1705-10. 2011
    ..HCN4 knockout (ciHCN4-KO) mouse model, ablation of HCN4 consistently leads to progressive development of severe bradycardia (∼50% reduction of original rate) and AV block, eventually leading to heart arrest and death in about 5 d...
  28. ncbi Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels
    Matteo E Mangoni
    Institut de Genomique Fonctionnelle, CNRS UMR5203 INSERM U661, Departement de Physiologie, Universite de Montpellier I, Montpellier Cedex 05, F 34094, France
    Circ Res 98:1422-30. 2006
    ..electrocardiograms on unrestrained mice and intracardiac recordings, we find that cacna1g inactivation causes bradycardia and delays atrioventricular conduction without affecting the excitability of the right atrium...
  29. ncbi The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
    Xiaoyan Qi
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 2:295-304. 2009
    Sustained bradycardia is associated with long-QT syndrome in human beings and causes spontaneous torsades de pointes in rabbits with chronic atrioventricular block (CAVB), at least partly by downregulating delayed-rectifier K(+)-current ..
  30. ncbi Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women
    A Brucato
    Niguarda Hospital, Milan, Italy
    Arthritis Rheum 44:1832-5. 2001
    ..In 2 centers, electrocardiography was recorded in 24 unselected newborns, and 4 were found to have sinus bradycardia. CONCLUSION: The prevalence of CCHB in newborns of prospectively followed up women already known to be anti-Ro/..
  31. ncbi Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release
    T Kishi
    Department of Cardiovascular Medicine, Cardiovascular Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertension 38:896-901. 2001
    ..Furthermore, these responses may be mediated by an increased release of GABA in the RVLM...
  32. pmc A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews
    Avishag Laish-Farkash
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cardiovasc Electrophysiol 21:1365-72. 2010
    to conduct a clinical, genetic, and functional analysis of 3 unrelated families with familial sinus bradycardia (FSB).
  33. ncbi Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib
    Sai Hong Ignatius Ou
    Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, California 92868 3298, USA
    J Thorac Oncol 6:2135-7. 2011
    ..We have observed several patients who developed profound but asymptomatic sinus bradycardia (HR ≤45) during the course of crizotinib treatment...
  34. ncbi Reflex bradycardia during surgery
    D J Doyle
    Department of Anaesthesia, Toronto General Hospital, Ontario
    Can J Anaesth 37:219-22. 1990
    Reflex bradycardia and sinus arrest may occur in a variety of surgical procedures, from neurosurgery to general abdominal, laparoscopic, ophthalmic and facial surgery and even procedures such as liver biopsies and electroconvulsive ..
  35. pmc Apnea, bradycardia and desaturation in preterm infants before and after feeding
    C Slocum
    Carillion Roanoke Community Hospital, Roanoke, VA, USA
    J Perinatol 29:209-12. 2009
    ..We aimed to measure objectively the effects of feeding on GER, apnea, bradycardia and desaturations.
  36. ncbi Carotid angioplasty and stent-induced bradycardia and hypotension: Impact of prophylactic atropine administration and prior carotid endarterectomy
    Neal S Cayne
    Department of Vascular Surgery, New York University Medical Center, NY 10016, USA
    J Vasc Surg 41:956-61. 2005
    We compared the physiologic effect of selective atropine administration for bradycardia with routine prophylactic administration, before balloon inflation, during carotid angioplasty and stenting (CAS)...
  37. ncbi Drugs that induce repolarization abnormalities cause bradycardia in zebrafish
    David J Milan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston 02129, USA
    Circulation 107:1355-8. 2003
    ..Current in vitro preclinical assays are limited by biological simplicity, and in vivo models suffer from expense and low throughput...
  38. pmc Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome
    Colleen E Clancy
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 110:1251-62. 2002
    ..These results link mutation-induced changes in Na+ channel gating mode transitions to heart rate-dependent changes in cellular electrical activity underlying a key LQT-3 clinical phenotype...
  39. ncbi Prognosis of the bradycardia pacemaker recipient assessed at first implantation: a nationwide cohort study
    Erik O Udo
    Department of Cardiology, UMC Utrecht, Utrecht, The Netherlands
    Heart 99:1573-8. 2013
    Pacing technology and care have improved notably over the past decade, justifying an update on the long-term prognosis and pre-implantation determinants of prognosis of bradycardia pacemaker (PM) recipients.
  40. ncbi NO-cGMP pathway at ventrolateral medullary cardiac inhibitory sites enhances the baroreceptor reflex bradycardia in the rat
    Janine Fletcher
    Department of Physiology, The Medical School, The University of Birmingham, Birmingham B15 2TT, UK
    Brain Res 1123:125-34. 2006
    ..caudal brainstem within and around the nucleus ambiguus was systematically explored for sites producing a bradycardia of >50 bpm, without a change in blood pressure, using D,L homocysteic acid (DLH, 0...
  41. ncbi Economic and health consequences of managing bradycardia with dual-chamber compared to single-chamber ventricular pacemakers in Italy
    Huseyin Baris Deniz
    Caro Research Institute, Concord, Massachusetts 01742, USA
    J Cardiovasc Med (Hagerstown) 9:43-50. 2008
    This study sought to estimate the economic implications of managing bradycardia due to sinoatrial node disease or atrioventricular block with dual compared to single-chamber ventricular pacemakers from an Italian government perspective...
  42. ncbi Biventricular pacing is superior to right ventricular pacing in bradycardia patients with preserved systolic function: 2-year results of the PACE trial
    Joseph Yat Sun Chan
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Institute of Vascular Medicine, Li Ka Shing Institute of Health and Sciences, The Chinese University of Hong Kong, Hong Kong
    Eur Heart J 32:2533-40. 2011
    ..In the current analysis, we report the results at extended 2-year follow-up for changes in LV function and remodelling...
  43. ncbi Periprocedural hemodynamic instability with carotid angioplasty and stenting
    Mahmoud M Taha
    Neurosurgery Department, Mie University School of Medicine, Mie, Japan
    Surg Neurol 70:279-85; discussion 285-6. 2008
    ..Carotid angioplasty and stenting is used for treatment of carotid stenosis. Stent deployment may induce HDI and thereby cause systemic or neurologic deficits. This study defines characteristics and predictors of HDI with CAS...
  44. ncbi Apnea-induced changes in time estimation and its relation to bradycardia
    Thibaud Jamin
    Laboratoire E S P EA 3162, Universite du Sud Toulon Var, La Garde, France
    Aviat Space Environ Med 75:876-80. 2004
    ..We tested time estimation (TE) during brief periods of voluntary apnea. We hypothesized that there would be a relationship between TE and heart rate (HR), a physiological indicator of arousal...
  45. ncbi Severe bradycardia and prolonged hypotension in ciguatera
    Thomas Yan Keung Chan
    Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Singapore Med J 54:e120-2. 2013
    ..In addition to those symptoms, he developed dizziness, severe bradycardia (46 bpm) and prolonged hypotension, which required the administration of intravenous atropine and over three ..
  46. ncbi A possible role for atrial fibroblasts in postinfarction bradycardia
    Andre Kamkin
    Institute of Physiology, Humboldt University, Charite, Berlin, Germany
    Am J Physiol Heart Circ Physiol 282:H842-9. 2002
    ..These findings suggest that changes in the susceptibility of atrial fibroblasts to mechanical stretch may contribute to bradyarrhythmia during postinfarct remodeling of the heart...
  47. ncbi Diabetes-induced bradycardia is an intrinsic metabolic defect reversed by carnitine
    Michael A Malone
    Julia Parrish Diabetes Research Institute, University of South Florida College of Medicine, Tampa, FL 33612 4742, USA
    Metabolism 56:1118-23. 2007
    Rats with streptozotocin-induced diabetes (STZ-D) have reduced serum carnitine levels and bradycardia. Heart rates (HRs) of 24nondiabetic rats (NRs) and 24 STZ-D rats were compared...
  48. ncbi Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension, and diuresis are absent in N/OFQ peptide (NOP) receptor knockout mice
    Melissa A Burmeister
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Pharmacol Exp Ther 326:897-904. 2008
    Intracerebroventricular administration of the opioid-like peptide nociceptin/orphanin FQ (N/OFQ) produces bradycardia, hypotension, and diuresis in mice...
  49. ncbi Temporal variability of atrial fibrillation in pacemaker recipients for bradycardia: implications for crossover designed trials, study sample size, and identification of responder patients by means of arrhythmia burden
    Giovanni Luca Botto
    Cardiology Department, S Anna Hospital, Como, Italy
    J Cardiovasc Electrophysiol 18:250-7. 2007
    ....
  50. ncbi Marked sinus bradycardia and QT prolongation in a diabetic patient with severe hypoglycemia
    Roberto Bolognesi
    Chair of Cardiology, Dipartment of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy
    J Diabetes Complications 25:349-51. 2011
    ..an uncommon case of an insulin-treated diabetic patient, presenting severe hypoglycemia, coma, marked sinus bradycardia and QT prolongation...
  51. ncbi Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation
    Nana Duhme
    Institute for Physiology and Pathophysiology, University of Heidelberg, INF 326, Heidelberg D 69120, Germany
    Eur Heart J 34:2768-75. 2013
    ..generation, regulation, and stabilization of heart rhythm and channel dysfunction is associated with inherited sinus bradycardia. We asked whether dysfunctional HCN4 channels also contribute to the generation of cardiac tachyarrhythmias.
  52. pmc The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Parks Road, OX1 3PT, UK
    J Mol Cell Cardiol 52:667-76. 2012
    ..We hypothesize that impaired bradycardia to peripheral vagal stimulation following high-level sympathetic drive is due to sympatho-vagal crosstalk by ..
  53. ncbi Symptomatic bradycardia with oral aripiprazole and oral ziprasidone
    Brian S Snarr
    Department of Medicine, Medical University of South Carolina, Charleston, USA
    Ann Pharmacother 44:760-3. 2010
    To describe the case of a patient who developed symptomatic bradycardia upon initiation of oral ziprasidone and later with oral aripiprazole, both of which resolved shortly after discontinuation of therapy.
  54. ncbi Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodies
    Priya Chockalingam
    Department of Pediatric Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    J Rheumatol 38:2682-5. 2011
    To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction.
  55. ncbi Functional basis of sinus bradycardia in congenital heart block
    Keli Hu
    Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System, SUNY Downstate Medical Center and NYU School of Medicine, Brooklyn, NY 11209, USA
    Circ Res 94:e32-8. 2004
    ..We recently established animal models of CHB and reported, for the first time, significant sinus bradycardia preceding AV block...
  56. ncbi Ruptured heterotopic pregnancy presenting with relative bradycardia in a woman not receiving reproductive assistance
    Michael P Somers
    Department of Emergency Medicine, University of Virginia Health System, Charlottesville, VA 22908 0699, USA
    Ann Emerg Med 43:382-5. 2004
    ..The patient failed to mount a tachycardic response to hemorrhagic shock. Bradycardia is a well-established phenomenon in the setting of hemoperitoneum and particularly with ruptured ectopic ..
  57. ncbi Orbital trauma, bradycardia, and vomiting: trapdoor fracture and the oculocardiac reflex: a case report
    Benjamin F Jackson
    Division of Emergency Medicine, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    Pediatr Emerg Care 26:143-5. 2010
    The presentation of vomiting and bradycardia after closed head trauma should invariably prompt concern for significant intracranial injury, yet other less common causes for the clinical picture do exist...
  58. ncbi Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway
    N Herring
    University Laboratory of Physiology, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H2318-27. 2001
    ..cGMP production act in a similar way to nitric oxide (NO) by enhancing acetylcholine release and vagal-induced bradycardia. The effects of enzyme inhibitors and channel blockers on the action of atrial natriuretic peptide (ANP), brain-..
  59. ncbi Fetal bradycardia and disseminated coagulopathy: atypical presentation of amniotic fluid emboli
    R Levy
    Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel
    Acta Anaesthesiol Scand 48:1214-5. 2004
    We present a parturient who developed an atypical case of amniotic fluid emboli presented by sudden fetal bradycardia, followed by maternal disseminated coagulopathy...
  60. ncbi Bradycardia during dexmedetomidine and therapeutic hypothermia
    Joseph D Tobias
    Department of Anesthesiology, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
    J Intensive Care Med 23:403-8. 2008
    ..Although generally safe and effective, occasional hemodynamic effects including bradycardia and hypotension have been reported...
  61. ncbi Cardiac effects of amodiaquine and sulfadoxine-pyrimethamine in malaria-infected African patients
    B Ngouesse
    , , , Cameroon
    Am J Trop Med Hyg 65:711-6. 2001
    ..Clinical and parasitological responses were monitored until Day 14. Bradycardia was observed in 16 of 20 amodiaquine-treated patients on Day 2, which corresponds to the time when maximal ..
  62. pmc Hyperkalaemia causing profound bradycardia
    K Noble
    Heart 92:1063. 2006
  63. ncbi Factors influencing intraoperative bradycardia in adult patients
    Tomoko Yorozu
    Department of Anesthesiology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Anesth 21:136-41. 2007
    In order to elucidate the prominent factors involved in intraoperative bradycardia in adult patients, we retrospectively investigated the association between the potential risk factors and intraoperative bradycardia, using multiple ..
  64. ncbi Frequency of hypotension and bradycardia during general anesthesia, epidural anesthesia, or integrated epidural-general anesthesia for total hip replacement
    Battista Borghi
    IRCSS Istituti Ortopedici, Rizzoli, Bologna, Italy
    J Clin Anesth 14:102-6. 2002
    To evaluate the frequency of hypotension and bradycardia during integrated epidural-general anesthesia as compared with general anesthesia or epidural anesthesia alone.
  65. ncbi Sinus bradycardia after intravenous pulse methylprednisolone
    Jonathan D Akikusa
    Division of Rheumatology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Pediatrics 119:e778-82. 2007
    ..Here we report our experience over a 6-month period with 5 children with rheumatic diseases who developed sinus bradycardia during consecutive daily therapy with intravenous pulse methylprednisolone...
  66. ncbi Acromegaly presenting with diabetic ketoacidosis, associated with retinitis pigmentosa and octreotide-induced bradycardia: a case report and a review of the literature
    Cihangir Erem
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
    Endocrine 30:145-9. 2006
    ..During the medical treatment with octreotide, symptomatic sinusoidal bradycardia was developed (pulse rate 45 bpm, and blood pressure 70/40 mmHg). Octreotide therapy was stopped...
  67. ncbi The effect of atrial pacing therapies on atrial tachyarrhythmia burden and frequency: results of a randomized trial in patients with bradycardia and atrial tachyarrhythmias
    Michael A Lee
    John Muir Mount Diablo Medical Center, Walnut Creek, California, USA
    J Am Coll Cardiol 41:1926-32. 2003
    ..The Atrial Therapy Efficacy and Safety Trial (ATTEST) was a prospective, randomized study to evaluate preventive pacing and antitachycardia pacing (ATP) in patients with symptomatic atrial fibrillation (AF) or atrial tachycardia (AT)...
  68. ncbi Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations
    Jean Marc Lupoglazoff
    Pediatric Cardiology, Necker Enfants Malades AP HP, Paris, France
    J Am Coll Cardiol 43:826-30. 2004
    ..We hypothesized that neonatal long QT syndrome (LQTS) with 2:1 atrioventricular block (AVB) could be related to HERG mutations...
  69. ncbi Severe maternal bradycardia and asystole after combined spinal-epidural labor analgesia in a morbidly obese parturient
    Peter H Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    J Clin Anesth 16:461-4. 2004
    Serious maternal bradycardia and asystole in laboring parturients after combined spinal-epidural labor analgesia are rare...
  70. pmc Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats
    Gregg R Ward
    Department of Pharmacology, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    BMC Pharmacol 6:2. 2006
    Previous studies have shown that testosterone enhances baroreflex bradycardia. Therefore, conscious unrestrained rats were used to investigate the role of the androgen receptor in the testosterone-mediated modulation of baroreflex ..
  71. ncbi [Relationship between efficacy of electroacupuncture and electroacupuncture stimulation of different acupoints and different tissue layers of acupoint area in hypotension plus bradycardia rats]
    Bin Xu
    Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of the People s Republic of China, Nanjing University of Chinese Medicine, Nanjing 210029, China
    Zhen Ci Yan Jiu 35:422-8. 2010
    ..between the effect of electroacupuncture (EA) and EA of different layer tissues of the acupoint area and different acupoints in upregulating mean arterial pressure (MAP) and heart rate (HR) in hypotension plus bradycardia rats.
  72. ncbi Heart rate regulation and extreme bradycardia in diving emperor penguins
    Jessica U Meir
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    J Exp Biol 211:1169-79. 2008
    ..In contrast to any other freely diving bird, a true bradycardia (f(H) significantly <f(H) at rest) occurred during diving [dive f(H) (total beats/duration)=57+/-2 beats min(..
  73. ncbi Repetitive paired stimulation of nasotrigeminal and peripheral chemoreceptor afferents cause progressive potentiation of the diving bradycardia
    Miroslav Rozloznik
    Dept of Neuro and Sensory Physiology, Georg August Univ Humboldtallee 23, 37073 Gottingen, Germany
    Am J Physiol Regul Integr Comp Physiol 296:R80-7. 2009
    Hallmarks of the mammalian diving response are protective apnea and bradycardia. These cardiorespiratory adaptations can be mimicked by stimulation of the trigeminal ethmoidal nerve (EN5) and reflect oxygen-conserving mechanisms during ..
  74. ncbi Bradycardia due to hydrogen peroxide irrigation during craniotomy for craniopharyngioma
    Hemanshu Prabhakar
    Department of Neuroanesthesiology, All India Institute of Medical Sciences, New Delhi 110029, India
    J Clin Neurosci 14:488-90. 2007
    ..A sudden bradycardia occurred after instillation of hydrogen peroxide solution at the surgical site...
  75. ncbi Changes in left ventricular repolarization and ion channel currents following a transient rate increase superimposed on bradycardia in anesthetized dogs
    M Rubart
    Department of Medicine, Indiana University School of Medicine, Krannert Institute of Cardiology, Indianapolis 46202 4800, USA
    J Cardiovasc Electrophysiol 11:652-64. 2000
    We previously demonstrated in dogs that a transient rate increase superimposed on bradycardia causes prolongation of ventricular refractoriness that persists for hours after resumption of bradycardia...
  76. ncbi Does heart rate variability predict hypotension and bradycardia after induction of general anaesthesia in high risk cardiovascular patients?
    R Hanss
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Anaesthesia 63:129-35. 2008
    ..measurement of heart rate variability and were then assigned according to haemodynamic events (hypotension or bradycardia) after standardised induction of anaesthesia into 'stable' (n = 39) and 'unstable' patients (n = 11)...
  77. ncbi Severe bradycardia after anesthesia before electroconvulsive therapy
    Tom K Birkenhager
    Departments of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
    J ECT 26:53-4. 2010
    Postanesthesia bradycardia or asystole before electroconvulsive therapy (ECT) occurs very infrequently but is a potentially fatal complication of pre-ECT anesthesia...
  78. ncbi Asystole and bradycardia related to anesthetic induction during ECT: a case report
    Mark J Russ
    J ECT 20:195-7. 2004
  79. ncbi GABAergic neurotransmission at the nucleus tractus solitarii in the suppression of reflex bradycardia by parabrachial nucleus
    W B Len
    Team of Biomedical Science, Chang-Gung Institute of Nursing, Taoyuan, Taiwan
    Synapse 42:27-39. 2001
    ..These results suggest that a direct GABAergic descending projection from the KF subnucleus and surrounding areas of the PBN complex to the NTS may inhibit cardiac BRR response by activating GABA(A) and GABA(B) receptors at the NTS...
  80. ncbi Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil?
    Koichi Maruyama
    Department of Anesthesiology, Saitama Medical University International Medical Center, 1397 1 Yamane, Hidaka, Saitama, 350 1298, Japan
    J Anesth 24:293-6. 2010
    This study was conducted to examine whether pretreatment with intravenous atropine could prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil in a prospective randomized ..
  81. ncbi Assessment of atrial regional wall motion using strain Doppler imaging during biatrial pacing in the bradycardia-tachycardia syndrome
    Katsumi Matsumoto
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Pacing Clin Electrophysiol 29:220-5. 2006
    ..Biatrial pacing is expected to have preventive effects on atrial fibrillation...
  82. ncbi Predictors of bradycardia during the stimulation phase of electroconvulsive therapy
    Josef Nagler
    Christophsbad Clinic, Goppingen, Germany
    J ECT 27:201-6. 2011
    ..Temporary asystole can be detected at various time points during electroconvulsive treatment. We carefully monitored and documented its incidence during stimulation to evaluate currently known and assumed predictors...
  83. ncbi Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension
    N R Keller
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, AA3228 MCN, Nashville, TN 37232 2195, USA
    Neuroscience 139:931-46. 2006
    ..Upon placement in the behavioral chamber, norepinephrine transporter-deficient mice demonstrated a notable bradycardia and depressor effect that was more pronounced in females...
  84. pmc Crisis management during anaesthesia: bradycardia
    L M Watterson
    Sydney Medical Simulation Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Qual Saf Health Care 14:e9. 2005
    b>Bradycardia in association with anaesthesia may have many potential causes and associated conditions, some rare and/or obscure. A prompt appropriate response is important as some homeostatic mechanisms may be impaired under anaesthesia.
  85. ncbi The relationship between sinus node dysfunction, bradycardia-mediated atrial remodelling, and post-operative atrial flutter in patients with congenital heart defects
    Natasja M S de Groot
    Eur Heart J 27:2036-7. 2006
  86. ncbi Bradycardia and hypotension refractory to ephedrine and atropine treatment: severe autonomic dysfunction with abnormal heart rate variability
    Huei Chi Horng
    Taichung Armed Forces General Hospital, Taiwan, ROC
    Acta Anaesthesiol Taiwan 44:109-12. 2006
    ..here report a 48-year-old male patient with diabetes mellitus who suffered from intraoperative hypotension and bradycardia which did not respond to ephedrine and atropine treatment and eventuated in cardiac arrest...
  87. ncbi Beneficial effects of biatrial pacing on cardiac function in patients with bradycardia -- tachycardia syndrome
    Katsumi Matsumoto
    Second Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
    Circ J 69:831-6. 2005
    ..Biatrial (BiA) pacing prevents atrial fibrillation. By an unknown mechanism. The purpose of this study was to use Doppler echocardiography to evaluate the hemodynamic effects during BiA pacing...
  88. ncbi Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control group
    Nathalie Costedoat-Chalumeau
    Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Arthritis Rheum 50:3187-94. 2004
    Aside from congenital heart block (CHB), sinus bradycardia and prolongation of the corrected QT (QTc) interval have been reported in infants born to mothers with anti-SSA antibodies...
  89. pmc Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro
    N Herring
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    J Physiol 535:507-18. 2001
    1. We tested the hypothesis that nitric oxide (NO) augments vagal neurotransmission and bradycardia via phosphorylation of presynaptic calcium channels to increase vesicular release of acetylcholine. 2...
  90. ncbi Bradycardia and hypotension associated with fomepizole infusion during hemodialysis
    Katherine J Lepik
    BC Drug and Poison Information Centre, Vancouver, British Columbia, Canada
    Clin Toxicol (Phila) 46:570-3. 2008
    We report a case of hypotension and bradycardia associated with intravenous fomepizole infusion.
  91. ncbi Biventricular pacing in patients with bradycardia and normal ejection fraction
    Cheuk Man Yu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    N Engl J Med 361:2123-34. 2009
    ..we examined whether biventricular pacing is superior to right ventricular apical pacing in preventing deterioration of left ventricular systolic function and cardiac remodeling in patients with bradycardia and a normal ejection fraction.
  92. ncbi Dexmedetomidine-associated bradycardia progressing to pulseless electrical activity: case report and review of the literature
    Anthony T Gerlach
    Department of Pharmacy, The Ohio State University Medical Center, Ohio 43210, USA
    Pharmacotherapy 29:1492. 2009
    ..It is a distinctive sedative because it does not cause respiratory depression, but it may cause hypotension and bradycardia. We describe a 74-year-old man who was receiving dexmedetomidine for agitation and experienced progressive ..
  93. ncbi How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures?
    Brian D Moseley
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Epilepsia 51:1219-24. 2010
    ..The purpose of this study was to determine the prevalence and risk factors for ictal hypoxemia (oxygen saturation <90%) and ictal bradycardia (heart rate < second percentile for age) in children during recorded seizures.
  94. ncbi Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require ANP receptor
    Lisa M Hunt
    Dept of Biology, Williams College, Williamstown, MA 01267, USA
    Am J Physiol Heart Circ Physiol 287:H1446-51. 2004
    ..Furthermore, circulating ANP levels and data from NPR1(-/-) and NPR3(-/-) mice suggest that the ANP pathway may not be involved in the cardiovascular response to CR...
  95. ncbi [Therapeutic drug monitoring in perioperative period--management of atrial fibrillation in a patient with bradycardia due to relative overdose of digitalis]
    T Murakawa
    Department of Anesthesiology, Odate Municipal Hospital
    Masui 46:521-4. 1997
    We reported a 79 year old man with preoperative bradycardia due to relative overdose of digitalis prior to undergoing subtotal gastrectomy. The patient had received metildigoxin 0.2 mg...
  96. ncbi The effect of electrode placement and pulsewidth on asystole and bradycardia during the electroconvulsive therapy stimulus
    Patrick T Stewart
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Int J Neuropsychopharmacol 14:585-94. 2011
    ..The degree of bradycardia (any slowing of heart rate) and incidence of asystole (absence of heart beats for ≥5 s) during the ECT ..
  97. ncbi Sudden bradycardia
    George Nikolic
    Intensive Care Unit, The Canberra Hospital, Canberra, Australia
    Heart Lung 40:177-9. 2011
  98. pmc Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation
    Robert A Rose
    Department of Physiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Circ Arrhythm Electrophysiol 4:733-42. 2011
    ..A major prognostic indicator of survival in patients with CIO is iron-mediated cardiomyopathy characterized by contractile dysfunction and electrical disturbances, including slow heart rate (bradycardia) and heart block.
  99. ncbi Bradycardia and vecuronium: comparison with alcuronium during cholecystectomy
    C P Morton
    Department of Anaesthetics, Royal Infirmary of Edinburgh
    Br J Anaesth 68:619-20. 1992
    We have compared the incidence of bradycardia in two groups of patients undergoing cholecystectomy...
  100. ncbi [Torsade de pointes associated with severe bradycardia after induction of general anesthesia]
    Eisuke Hamaguchi
    Department of Anesthesiology, Tokushima University Hospital, Tokushima 770 8503
    Masui 60:1097-100. 2011
    ..Just after induction of anesthesia, sinus bradycardia occurred, and 9 minutes after tracheal intubation, ECG suddenly showed torsade de pointes (TdP) and the ..
  101. ncbi Reflex bradycardia in facial surgery
    D G Stott
    Department of Anaesthetics, Stepping Hill Hospital, Stockport
    Br J Plast Surg 42:595-7. 1989
    ..An awareness of its management can obviate morbidity and mortality. An account of the phenomenon, its treatment and illustrative case histories are presented...

Research Grants66

  1. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs and TdP...
  2. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..persons, individuals with tetraplegia represent a model of sympathetic denervation characterized by relative bradycardia and low resting blood pressure...
  3. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..Acute administration of T1AM rapidly induces hypothermia, bradycardia, and hyperglycemia in rodents...
  4. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..Single doses of T1AM rapidly induce hypothermia, bradycardia, and hyperglycemia in rodents...
  5. AREA: Rapamycin, ambient temperature, and longevity
    Steven J Swoap; Fiscal Year: 2010
    ..also requires the same cold stress for maximum lifespan extension, 2) significant metabolic depression, bradycardia, and hypothermia are required for rapamycin's effect on lifespan extension, and 3) despite a normal body ..
  6. NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONS
    David Mendelowitz; Fiscal Year: 2013
    ..Acute exposure to hypoxia evokes an initial tachycardia followed by a bradycardia. Previous work from this lab, and others, have shown brief (5-15 minute) periods of hypoxia and/or hypercapnia ..
  7. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2013
    ..of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
  8. CaMKII in Sinus Node Physiology and Disease
    Mark E Anderson; Fiscal Year: 2013
    ..SND causes symptomatic bradycardia and sudden death, particularly in patients and animal models with hypertension or heart failure, conditions ..
  9. PARASYMPATHETIC DYSFUNCTION IN OBESITY: EFFECT OF CHOLESTEROL ON VAChT
    Yifan Li; Fiscal Year: 2013
    ..Vagal stimulation (VS)-induced bradycardia and Ach release in atria, and VAChT protein levels and Ach uptake activity in synaptic vesicles from PSNS ..
  10. Mechanisms of cardiac Ca dysregulation and arrhythmias in ankyrin B deficiency
    Sanda Despa; Fiscal Year: 2013
    ..LQT4, humans with AnkB loss-of-function mutations display a complex cardiac phenotype that also includes bradycardia, stress-induced ventricular arrhythmias and sudden cardiac death...
  11. MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATES
    David Mendelowitz; Fiscal Year: 2013
    The diving reflex is the most powerful autonomic reflex. Stimulation of the diving reflex evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
  12. Thyroid Hormone Action
    Thomas Scanlan; Fiscal Year: 2009
    ..T1AM rapidly induces hypothermia, bradycardia, and hyperglycemia in rodents...
  13. Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neurons
    Eugen Brailoiu; Fiscal Year: 2012
    ..that microinjection of G-1, a specific GPR30 agonist, or 17-estradiol (E2) into the nucleus ambiguus produces bradycardia;the effect was abolished by prior administration of G-36, a GPR30 antagonist...
  14. Actuated, Low-Stress, Endotracheal Tube Cleaner to Improve Neonate Lung Function
    ROGER BROOKS BAGWELL; Fiscal Year: 2013
    ..Risks associated with suctioning include hypoxia (low oxygen in blood), bradycardia (low heart rate), or atelectasis (collapse of part of the lung)...
  15. Prenatal ethanol exposure, arousal and the Sudden Infant Death Syndrome (SIDS)
    Robert A Darnall; Fiscal Year: 2013
    ..die of SIDS, however, have arousal deficits that prevent an adequate response to multiple episodes of apnea, bradycardia and hypoxia...
  16. Abstinence and Drug Withdrawal: Innovative Translational Methods for Neonates
    ELISABETH BLOCH SALISBURY; Fiscal Year: 2013
    ..g., bradycardia, tachycardia) and respiration, including decreasing incidents of apnea, periodic breathing and tachypnea;2) ..
  17. Wireless Novel MicroEEG for Neonatal Apnea and Community Neurological Network
    ZACHARY H IBRAHIM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Most preterm infants have episodes of apnea (cessation of breathing), bradycardia (low heart rate), and desaturations (low levels of oxygen in the blood) or what is collectively called as ABD events...
  18. TRPV1 Function at Laryngeal Labeled NTS Neurons
    Mackenzie E Hofmann; Fiscal Year: 2013
    ..Activation of this reflex results in apnea and bradycardia and can be prolonged by temperature increases in the nucleus of the solitary tract (NTS) in the brainstem...
  19. Characterization of autonomic dysfunction in Rett syndrome &other MECP2 disorder
    Jeffrey L Neul; Fiscal Year: 2013
    ..Boys with mutations in MECP2 and congenital encephalopathy have a number of autonomic abnormalities including bradycardia, apnea, and respiratory arrest resulting in death in the first three years of life...
  20. MIR-1-2 FUNCTION IN CARDIAC CONDUCTION SYSTEM DEVELOPMENT AND MAINTENANCE
    Yong Zhao; Fiscal Year: 2013
    ..miR-1s repress cell proliferation. Overexpression of miR-1-2 causes bradycardia and arrhythmias...
  21. Identification of the anti-neoplastic target of bioactive FTY720 analogs
    Stephen Hanessian; Fiscal Year: 2013
    ..success in animal models, FTY720 cannot be tested in human cancer patients because it triggers profound bradycardia by activating S1P receptors 1 and 3 before the anti-neoplastic dose is reached...
  22. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    ..A broader spectrum of autonomic signs, including changes in heart rate and rhythm (most often bradycardia), blood pressure (most often pressure increases), pupillary size, vasomotor and sudomotor activity, GI motility ..
  23. Unbiased screens in zebrafish for new classes of cyanide countermeasure
    Calum A Macrae; Fiscal Year: 2011
    ..We have developed a zebrafish model in which exposure to cyanide causes stereotypical toxicities including bradycardia, neuronal necrosis, and death...
  24. CELLULAR BIOLOGY OF CARDIAC SODIUM-CALCIUM EXCHANGE
    KENNETH PHILIPSON; Fiscal Year: 2013
    ..recently produced novel atrial-specific NCX knockout (KO) mice that live into adulthood, but exhibit profound bradycardia and sinaotrial node (SAN) dysfunction...
  25. Sensory C Fibers in the Upper Airways
    THOMAS EDWARD TAYLOR-CLARK; Fiscal Year: 2011
    ..itch, congestion, mucus secretion, bronchospasm, altered respiratory pattern, arterial hypotension and bradycardia. The specific nature of a given reflex response is likely due to the type of upper airway afferent nerve that ..
  26. Activity dependent mechanisms of olfactory system development
    Arie Sitthichai Mobley; Fiscal Year: 2013
    ..The experiments proposed here may have broad implications for Ih channelopathies including sinus bradycardia, epilepsy, and peripheral neuropathic pain.
  27. Ultra Low Power Integrated Circuits and Systems for Cardiac Pacemakers
    Eugene B John; Fiscal Year: 2013
    ..any part of the conduction system is dysfunctional for some reason, the normal heartbeat may become too slow (bradycardia) or fast (tachycardia100bpm). These are abnormal heart rhythms, or arrhythmias...
  28. OPIOMELANOCORTIN PEPTIDES AND CARDIOVASCULAR REGULATION
    George Kunos; Fiscal Year: 1999
    ..in rats, we will define the alpha-2 AR sub-types in the arcuate nucleus which mediate hypotension and bradycardia. Inhibition of these effects in the NTS by anti-sera against the beta-endorphin and alpha-MSH or by antagonists ..
  29. UNDERSTANDING THE ROLES OF MIR-1S IN REGULATING HEART DEVELOPMENT
    Yong Zhao; Fiscal Year: 2013
    ..Overexpression of miR-1-2 at postnatal stages causes AV block of various degree and sinus bradycardia. The PI hypothesizes that the proper function of each component of the CCS requires a precise dosage of miR-1...
  30. CNS MEDIATION OF CONDITIONED BRADYCARDIA
    PHILIP MC CABE; Fiscal Year: 1990
    ..In the rabbit, the conditioned heart rate response consists of heart rate slowing (bradycardia)...
  31. PACEmaker &Beta-Blocker Therapy Post-Myocardial Infarct
    Jeffrey J Goldberger; Fiscal Year: 2013
    ..of total mortality plus nonfatal reinfarction in patients who have suffered a myocardial infarction and have bradycardia contraindications to beta blockers...
  32. Planning Grant for PRESOX Trial
    Neil Finer; Fiscal Year: 2009
    ..either 30% or 60% oxygen, and the oxygen concentration will be increased in the Low group for either continued bradycardia, or SpO2 values of less than 70% at 4 minutes, or less than 80% at 7 minutes, and Na SpO2 of 85% at 10 minutes...
  33. AUTONOMIC FUNCTION IN RENOVASCULAR HYPERTENSION
    BARBARA BARRON; Fiscal Year: 2000
    ..For instance, enkephalins reduce vagally-mediated bradycardia. Conversely, adrenergic stimulation to cardiomyocytes causes increased enkephalin production...
  34. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
    ..2. To identify sound characteristics in NICUs that disrupt sleep or increase episodes of apnea, bradycardia, or desaturation in ELBW infants...
  35. TRH in mediating the bradycardia of caloric restriction
    Steven Swoap; Fiscal Year: 2005
    ..The overall goal of this proposal is to elucidate the underlying mechanism(s) of the bradycardia induced by the reduction of caloric intake...
  36. Trigeminal Autonomic Interactions
    Paul McCulloch; Fiscal Year: 2002
    ..This reflex includes central apnea, parasympathetic bradycardia and sympathetically mediated vasoconstriction...
  37. PRECISE CONTOL OF TONGUE MOVEMENT
    Stephen Goldberg; Fiscal Year: 2005
    ..Attempts to begin bottle feeding these infants can result in apnea, bradycardia, hypoxia, fatigue and agitation and there can also be the long term consequence of delayed oral feeding ..
  38. Neuroplasticity and the carotid body
    Estelle Gauda; Fiscal Year: 2009
    ..Furthermore, these infants are at high risk for persistent apnea and bradycardia, reduced arousal responses during sleep, and sudden death which are all adverse physiological events related to ..
  39. Role of Ca channels in congenital heart block
    Mohamed Boutjdir; Fiscal Year: 2007
    ..We have also reported for the first time significant sinus bradycardia unrelated to AV block...
  40. ELECTROPHYSIOLOGY OF RIGHT ATRIAL PACEMAKERS
    STEPHEN LIPSIUS; Fiscal Year: 2000
    ..e. postvagal tachycardia, 2) digitalis elicits a bradycardia by somehow sensitizing the atria to cholinergic inhibition, 3) nitric oxide may play an obligatory role in the ..
  41. Air Pollution and Cardiorespiratory Events In Infants
    Paige Tolbert; Fiscal Year: 2003
    ..the first of its kind, is to examine the occurrence of cardiorespiratory events (in particular, apnea and bradycardia) in infants on home cardiorespiratory monitors in relation to daily measures of ambient air pollution in the ..
  42. OXYGEN SATURATION MONITORING IN NEONATES
    SHYANG YUN SHIAO; Fiscal Year: 2001
    ..Neonates on ventilators are more sensitive to stimuli and frequently develop desaturation episodes, apnea, and bradycardia. They are at greater risk of hypoxemia, in part because of their high fetal hemoglobin level...
  43. ENDOTRACHEAL SUCTIONING IN NEWBORNS
    Barbara Turner; Fiscal Year: 1993
    ..ventilator) and level of hyperoxygenation (10% vs 20% increase in FIO2) to prevent suction induced hypoxemia, bradycardia, hyper/hypocarbia and increased ICP...
  44. HYPOTHYROID AND AUTONOMIC CHANGES--ROLE OF MEDULLARY TRH
    Hong Yang; Fiscal Year: 1999
    The central mechanisms responsible for the bradycardia, high blood pressure, gastrointestinal motility disorder, and gastric atrophy induced by hypothyroidism remains unknown...
  45. The Role of Epinephrine in Neurally Mediated Syncope
    Satish Raj; Fiscal Year: 2009
    ..followed by a sudden withdrawal of sympathetic tone and increase in vagal tone, with resultant vasodilation and bradycardia. Recent studies have found that the level of epinephrine rises PRIOR to syncope...
  46. Role of Cardiac Fibrosis in Arrhythmogenesis
    Amy de Jongh Curry; Fiscal Year: 2006
    ..In addition, 30-50% of these deaths are sudden and have been attributed to ventricular tachyarrhythmias, bradycardia, and electro-mechanical dissociation...
  47. Coupling mechanisms of OP4 receptor and calcium channels
    Victor Ruiz Velasco; Fiscal Year: 2006
    ..Noc-mediated OP4 receptor activation elicits cardiovascular responses such as bradycardia and hypotension via pathways that influence the autonomic nervous system--mostly through an inhibition of ..
  48. NURSING INTERVENTIONS USED IN FEEDING PRETERM INFANTS
    ALICE HILL; Fiscal Year: 2002
    ..g., apnea, bradycardia, oxygen desaturation, untoward changes in behavioral state changes, and changes in sucking pattern ..
  49. Predicting life-threatening events in CHIME infant data
    Stephanie Schuckers; Fiscal Year: 2003
    ..is a relationship between SIDS and infants who have apparent life-threatening events (ALTE) like apnea and bradycardia, there is a desire to gain a better understanding of the nature of ALTE, their frequency and severity, and the ..
  50. HOME APNEA MONITORING IN INFANTS AT RISK FOR SIDS
    Toke Hoppenbrouwers; Fiscal Year: 1991
    ..These infants will participate in a program involving home monitoring of apnea, bradycardia and oxygen with computer storage of these events...
  51. 5-HT1A-agonist mediated recovery in hypovolemic shock
    Karie Scrogin; Fiscal Year: 2007
    ..These compensatory responses suddenly abate after significant blood loss (20-30%), resulting in hypotension, bradycardia and sympathoinhibition...
  52. NON-CONTACT MONITOR FOR INFANTS AT RISK FOR SIDS
    DAVID GERDT; Fiscal Year: 1999
    ..The strategy is to detect such episodes of bradycardia and apnea at their inception, and then to physically the arouse the child...
  53. Wireless Cardiorespiratory Monitor for Neonates
    MICHAEL SCIARRA; Fiscal Year: 2004
    ..adapt the respiratory sensor to distinguish between central, obstructed, or mixed apnea; 2) implement apnea and bradycardia event detection; 3) explore implementation of an oximetric sensor; and 4) expand the validation study beyond ..
  54. ELECTROPHYSIOLOGY OF CARDIAC AUTOMATICITY
    Joseph Spear; Fiscal Year: 1980
    ..experiments will provide information relevant to mechanisms of various cardiac arrhythmias including sinus node bradycardia, sinus arrest, bradycardia-tachycardia syndrome, sinus node exit block, sinus node reenINVALID ACTION CODE ..
  55. Newborn brain oxygenation and cellular injury
    Anna Pastuszko; Fiscal Year: 2005
    ..Apneic episodes longer than 15 s and accompanied by hypoxia or bradycardia have been reported to occur in all infants with gestational ages less than 34 weeks...
  56. Functional basis of bradycardia in congenital heart bloc
    Yongxia Qu; Fiscal Year: 2005
    The long-term goal is to elucidate the mechanisms underlying autoimmune-associated sinus bradycardia. Significant sinus bradycardia was observed in infants from mothers with anti-Ro/La autoantibodies, and in pups from Ro/La immunized ..
  57. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
    ..This second or ~ decompensatory~ phase of hemorrhage is characterized by bradycardia and a sharp decrease of sympathetic activity ( hemorrhage-induced sympathoinhibiton...
  58. A Molecular Study of Cardiac Repolarization
    David Milan; Fiscal Year: 2009
    ..Our preliminary data suggest that disturbances of repolarization are manifest as bradycardia in the zebrafish, and that this organism will provide a good model for the analysis of cardiac repolarization...
  59. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Martin Farias; Fiscal Year: 2002
    ..that: MEAP acting on delta II opioid receptors located prejunctionally in the sinoatrial node suppresses vagal bradycardia by interrupting the NOcGMP pathway. 1...
  60. A 4-Pole Micro-Leadwire for Multi-Chamber Cardiac Pacing
    Geoffrey Kotzar; Fiscal Year: 2001
    ..5 billion last year. This market includes bradycardia implants, implantable cardioverter defibrillators (ICD), and external automated defibrillators...
  61. Zebrafish Screen for Drug-Induced Long QT & Cyp3A
    TIMOTHY BARANOWSKI; Fiscal Year: 2005
    ..A recent study showed that compounds that cause long QT in humans cause bradycardia in live zebrafish embryos...
  62. A MICRO-STIMULATION LEADWIRE FOR CARDIAC PACING
    BRYAN BOHANAN; Fiscal Year: 2000
    ..5 billion last year. This market includes bradycardia implants, implantable cardioverter defibrillators (ICD), and external automated defibrillators...
  63. Genetic Studies of Cardiac Pacemaking in the Zebrafish
    Calum MacRae; Fiscal Year: 2004
    ..The zebrafish mutant slo mo (smo) displays heritable intrinsic bradycardia but exhibits no other developmental defect...
  64. GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    Morton Printz; Fiscal Year: 2007
    ..genes in new QTL discovered for mild airpuff startle stress-elicited tachycardia and pressor responses, for bradycardia associated with the Orienting Response, and for a cluster of blood pressure QTL on chromosome 2. Dr...
  65. THE CPA: SOMATIC AND AUTONOMIC SYSTEMS
    W Panneton; Fiscal Year: 2004
    ..Understanding the brainstem mechanisms governing he vascular constriction after either of these somatic stimuli may provide a neurological explanation for this. Such knowledge may lead to an understanding of essential hypertension. ..
  66. Behavioral state development in infants
    Mark Blumberg; Fiscal Year: 2009
    ..abstract_text> ..