bradycardia

Summary

Summary: Excessive slowness in the action of the heart, usually with a heart rate below 60 beats per minute.

Top Publications

  1. doi Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
    Shahid M Baig
    Human Molecular Genetics Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
    Nat Neurosci 14:77-84. 2011
  2. ncbi Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflex
    S M Kinsella
    Sir Humphry Davy Department of Anaesthesia, St Michael's Hospital, Bristol, UK
    Br J Anaesth 86:859-68. 2001
  3. pmc Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4
    Mirko Baruscotti
    Department of Biomolecular Sciences and Biotechnology, PaceLab and Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata, Milano, Universita degli Studi di Milano, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 108:1705-10. 2011
  4. ncbi Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families
    Marieke W Veldkamp
    Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 92:976-83. 2003
  5. ncbi Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors
    John T Fisher
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    FASEB J 18:711-3. 2004
  6. pmc Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients
    A V Postma
    J Med Genet 42:863-70. 2005
  7. ncbi Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia
    Atsunori Kamiya
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1 Hujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 289:H1758-69. 2005
  8. ncbi Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia
    Yongxia Qu
    VA New York Harbor Healthcare System, New York, NY, USA
    Circulation 111:3034-41. 2005
  9. ncbi Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart
    Rie Schultz Hansen
    Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 321:996-1002. 2007
  10. ncbi Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels
    Matteo E Mangoni
    Institut de Genomique Fonctionnelle, CNRS UMR5203 INSERM U661, Departement de Physiologie, Universite de Montpellier I, Montpellier Cedex 05, F 34094, France
    Circ Res 98:1422-30. 2006

Detail Information

Publications321 found, 100 shown here

  1. doi Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
    Shahid M Baig
    Human Molecular Genetics Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
    Nat Neurosci 14:77-84. 2011
    ..We describe a human channelopathy (termed SANDD syndrome, sinoatrial node dysfunction and deafness) with a cardiac and auditory phenotype that closely resembles that of Cacna1d(-/-) mice...
  2. ncbi Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflex
    S M Kinsella
    Sir Humphry Davy Department of Anaesthesia, St Michael's Hospital, Bristol, UK
    Br J Anaesth 86:859-68. 2001
    Reflex cardiovascular depression with vasodilation and bradycardia has been variously termed vasovagal syncope, the Bezold-Jarisch reflex and neurocardiogenic syncope...
  3. pmc Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4
    Mirko Baruscotti
    Department of Biomolecular Sciences and Biotechnology, PaceLab and Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata, Milano, Universita degli Studi di Milano, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 108:1705-10. 2011
    ..HCN4 knockout (ciHCN4-KO) mouse model, ablation of HCN4 consistently leads to progressive development of severe bradycardia (∼50% reduction of original rate) and AV block, eventually leading to heart arrest and death in about 5 d...
  4. ncbi Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families
    Marieke W Veldkamp
    Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 92:976-83. 2003
    ..In addition to the characteristic QT prolongation, LQT3 carriers regularly present with bradycardia and sinus pauses...
  5. ncbi Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors
    John T Fisher
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    FASEB J 18:711-3. 2004
    ..ligands, have complicated the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due to vagal innervation...
  6. pmc Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients
    A V Postma
    J Med Genet 42:863-70. 2005
    ..The aim of the study was to assess underlying genetic cause(s), clinical features, and response to therapy in catecholaminergic polymorphic ventricular tachycardia (CPVT) probands...
  7. ncbi Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia
    Atsunori Kamiya
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1 Hujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 289:H1758-69. 2005
    ..LF oscillation of MSNA variability decreased during development of orthostatic neurally mediated syncope, preceding sympathetic withdrawal, bradycardia, and severe hypotension, to the level at syncope.
  8. ncbi Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia
    Yongxia Qu
    VA New York Harbor Healthcare System, New York, NY, USA
    Circulation 111:3034-41. 2005
    ..Although the hallmark of CHB is complete atrioventricular block, sinus bradycardia has been reported recently in animal models of CHB...
  9. ncbi Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart
    Rie Schultz Hansen
    Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 321:996-1002. 2007
    ..Taken together, the present data strongly support the concept of using hERG activators as a treatment for certain kinds of arrhythmias and suggest further investigation of this new approach...
  10. ncbi Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels
    Matteo E Mangoni
    Institut de Genomique Fonctionnelle, CNRS UMR5203 INSERM U661, Departement de Physiologie, Universite de Montpellier I, Montpellier Cedex 05, F 34094, France
    Circ Res 98:1422-30. 2006
    ..electrocardiograms on unrestrained mice and intracardiac recordings, we find that cacna1g inactivation causes bradycardia and delays atrioventricular conduction without affecting the excitability of the right atrium...
  11. doi Cholinesterase inhibitors and incidence of bradycardia in patients with dementia in the veterans affairs new England healthcare system
    Rohini K Hernandez
    Cooperative Studies Program, Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    J Am Geriatr Soc 57:1997-2003. 2009
    To quantify the association between cholinesterase inhibitors (ChE-Is) and a new diagnosis of bradycardia and to evaluate the clinical significance of bradycardia.
  12. ncbi The development of diving bradycardia in bottlenose dolphins (Tursiops truncatus)
    S R Noren
    Ecology and Evolutionary Biology Department, Center for Ocean Health, University of California, Santa Cruz, CA 95060, USA
    J Comp Physiol B 174:139-47. 2004
    b>Bradycardia is an important component of the dive response, yet little is known about this response in immature marine mammals...
  13. ncbi Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford University OX1 3PT, UK
    J Mol Cell Cardiol 44:477-85. 2008
    ..Y (NPY), released during prolonged cardiac sympathetic nerve stimulation, can attenuate vagal-induced bradycardia. We tested the hypothesis that NPY reduces acetylcholine release, at similar concentrations to which it ..
  14. doi Bradycardia leading to asystole during dexmedetomidine infusion in an 18 year-old double-lung transplant recipient
    Xiaopeng Zhang
    Division of Anesthesiology, Geisinger Medical Center, Danville, PA 17821, USA
    J Clin Anesth 22:45-9. 2010
    ..transplant recipient recovering from acute respiratory distress syndrome who developed repeated episodes of bradycardia and asystole (maximum duration: 10 sec) during dexmedetomidine administration is presented...
  15. ncbi Cardiac effects of amodiaquine and sulfadoxine-pyrimethamine in malaria-infected African patients
    B Ngouesse
    , , , Cameroon
    Am J Trop Med Hyg 65:711-6. 2001
    ..Clinical and parasitological responses were monitored until Day 14. Bradycardia was observed in 16 of 20 amodiaquine-treated patients on Day 2, which corresponds to the time when maximal ..
  16. ncbi Pediatric rapid sequence intubation: incidence of reflex bradycardia and effects of pretreatment with atropine
    Rebecca K Fastle
    Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center and The Children s Hospital, Denver, CO, USA
    Pediatr Emerg Care 20:651-5. 2004
    The American College of Emergency Physicians (ACEP) recommends atropine as adjunctive therapy to prevent reflex bradycardia prior to laryngoscopy/tracheal intubation (L/TI) in pediatric patients.
  17. ncbi Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes
    Yukiomi Tsuji
    Research Center, Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Circulation 113:345-55. 2006
    ..Uncontrolled tachycardia produces heart failure and ventricular tachyarrhythmia susceptibility, whereas bradycardia promotes spontaneous torsade de pointes (TdP)...
  18. ncbi Fetal bradycardia and disseminated coagulopathy: atypical presentation of amniotic fluid emboli
    R Levy
    Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel
    Acta Anaesthesiol Scand 48:1214-5. 2004
    We present a parturient who developed an atypical case of amniotic fluid emboli presented by sudden fetal bradycardia, followed by maternal disseminated coagulopathy...
  19. doi Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia
    Luiza Michelle Cangussu
    Departamento de Ciencias Biologicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil
    Peptides 30:1921-7. 2009
    ..and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C)...
  20. ncbi Hypotension, bradycardia and syncope caused by honey poisoning
    Ozcan Yilmaz
    Ondokuz Mayis University School of Medicine, Department of Cardiology, Kurupelit, Samsun, Turkey
    Resuscitation 68:405-8. 2006
    ..with a variety of symptoms including nausea, vomiting, salivation, dizziness, weakness, hypotension, bradycardia and syncope several hours after the ingestion of small amounts of honey...
  21. pmc Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibition
    Boyoung Joung
    Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University Schoolof Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Heart Circ Physiol 299:H634-42. 2010
    ..Combined malfunction of both membrane and Ca(2+) clocks underlies the mechanisms of PSPs...
  22. ncbi Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release
    T Kishi
    Department of Cardiovascular Medicine, Cardiovascular Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertension 38:896-901. 2001
    ..Furthermore, these responses may be mediated by an increased release of GABA in the RVLM...
  23. ncbi Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development
    Rudiger J Blaschke
    Human Genetics, University of Heidelberg, Heidelberg, Germany
    Circulation 115:1830-8. 2007
    ..Here, we report on a highly restricted expression pattern of the homeodomain transcription factor Shox2 in the sinus venosus myocardium, including the sinoatrial nodal region and the venous valves...
  24. ncbi Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women
    A Brucato
    Niguarda Hospital, Milan, Italy
    Arthritis Rheum 44:1832-5. 2001
    ..In 2 centers, electrocardiography was recorded in 24 unselected newborns, and 4 were found to have sinus bradycardia. CONCLUSION: The prevalence of CCHB in newborns of prospectively followed up women already known to be anti-Ro/..
  25. doi Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib
    Sai Hong Ignatius Ou
    Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, California 92868 3298, USA
    J Thorac Oncol 6:2135-7. 2011
    ..We have observed several patients who developed profound but asymptomatic sinus bradycardia (HR ≤45) during the course of crizotinib treatment...
  26. ncbi Carotid angioplasty and stent-induced bradycardia and hypotension: Impact of prophylactic atropine administration and prior carotid endarterectomy
    Neal S Cayne
    Department of Vascular Surgery, New York University Medical Center, NY 10016, USA
    J Vasc Surg 41:956-61. 2005
    We compared the physiologic effect of selective atropine administration for bradycardia with routine prophylactic administration, before balloon inflation, during carotid angioplasty and stenting (CAS)...
  27. pmc Apnea, bradycardia and desaturation in preterm infants before and after feeding
    C Slocum
    Carillion Roanoke Community Hospital, Roanoke, VA, USA
    J Perinatol 29:209-12. 2009
    ..We aimed to measure objectively the effects of feeding on GER, apnea, bradycardia and desaturations.
  28. ncbi Reflex bradycardia during surgery
    D J Doyle
    Department of Anaesthesia, Toronto General Hospital, Ontario
    Can J Anaesth 37:219-22. 1990
    Reflex bradycardia and sinus arrest may occur in a variety of surgical procedures, from neurosurgery to general abdominal, laparoscopic, ophthalmic and facial surgery and even procedures such as liver biopsies and electroconvulsive ..
  29. ncbi Drugs that induce repolarization abnormalities cause bradycardia in zebrafish
    David J Milan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston 02129, USA
    Circulation 107:1355-8. 2003
    ..Current in vitro preclinical assays are limited by biological simplicity, and in vivo models suffer from expense and low throughput...
  30. pmc Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome
    Colleen E Clancy
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 110:1251-62. 2002
    ..These results link mutation-induced changes in Na+ channel gating mode transitions to heart rate-dependent changes in cellular electrical activity underlying a key LQT-3 clinical phenotype...
  31. pmc Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats
    Gregg R Ward
    Department of Pharmacology, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    BMC Pharmacol 6:2. 2006
    Previous studies have shown that testosterone enhances baroreflex bradycardia. Therefore, conscious unrestrained rats were used to investigate the role of the androgen receptor in the testosterone-mediated modulation of baroreflex ..
  32. ncbi Assessment of atrial regional wall motion using strain Doppler imaging during biatrial pacing in the bradycardia-tachycardia syndrome
    Katsumi Matsumoto
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Pacing Clin Electrophysiol 29:220-5. 2006
    ..Biatrial pacing is expected to have preventive effects on atrial fibrillation...
  33. ncbi Bradycardia due to hydrogen peroxide irrigation during craniotomy for craniopharyngioma
    Hemanshu Prabhakar
    Department of Neuroanesthesiology, All India Institute of Medical Sciences, New Delhi 110029, India
    J Clin Neurosci 14:488-90. 2007
    ..A sudden bradycardia occurred after instillation of hydrogen peroxide solution at the surgical site...
  34. ncbi Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension
    N R Keller
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, AA3228 MCN, Nashville, TN 37232 2195, USA
    Neuroscience 139:931-46. 2006
    ..Upon placement in the behavioral chamber, norepinephrine transporter-deficient mice demonstrated a notable bradycardia and depressor effect that was more pronounced in females...
  35. ncbi Changes in left ventricular repolarization and ion channel currents following a transient rate increase superimposed on bradycardia in anesthetized dogs
    M Rubart
    Department of Medicine, Indiana University School of Medicine, Krannert Institute of Cardiology, Indianapolis 46202 4800, USA
    J Cardiovasc Electrophysiol 11:652-64. 2000
    We previously demonstrated in dogs that a transient rate increase superimposed on bradycardia causes prolongation of ventricular refractoriness that persists for hours after resumption of bradycardia...
  36. ncbi GABAergic neurotransmission at the nucleus tractus solitarii in the suppression of reflex bradycardia by parabrachial nucleus
    W B Len
    Team of Biomedical Science, Chang-Gung Institute of Nursing, Taoyuan, Taiwan
    Synapse 42:27-39. 2001
    ..These results suggest that a direct GABAergic descending projection from the KF subnucleus and surrounding areas of the PBN complex to the NTS may inhibit cardiac BRR response by activating GABA(A) and GABA(B) receptors at the NTS...
  37. doi Does heart rate variability predict hypotension and bradycardia after induction of general anaesthesia in high risk cardiovascular patients?
    R Hanss
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Anaesthesia 63:129-35. 2008
    ..measurement of heart rate variability and were then assigned according to haemodynamic events (hypotension or bradycardia) after standardised induction of anaesthesia into 'stable' (n = 39) and 'unstable' patients (n = 11)...
  38. doi Prolonged and symptomatic bradycardia following a single dose of fingolimod
    Hans Faber
    Neurology, Max Planck Institute of Psychiatry, Munich, Germany
    Mult Scler 19:126-8. 2013
    Fingolimod-related bradycardia is usually asymptomatic, reaches its nadir within 6 hours post-dose and recovers spontaneously...
  39. ncbi Asystole and bradycardia related to anesthetic induction during ECT: a case report
    Mark J Russ
    J ECT 20:195-7. 2004
  40. doi Severe bradycardia after anesthesia before electroconvulsive therapy
    Tom K Birkenhager
    Departments of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
    J ECT 26:53-4. 2010
    Postanesthesia bradycardia or asystole before electroconvulsive therapy (ECT) occurs very infrequently but is a potentially fatal complication of pre-ECT anesthesia...
  41. doi Predictors of bradycardia during the stimulation phase of electroconvulsive therapy
    Josef Nagler
    Christophsbad Clinic, Goppingen, Germany
    J ECT 27:201-6. 2011
    ..Temporary asystole can be detected at various time points during electroconvulsive treatment. We carefully monitored and documented its incidence during stimulation to evaluate currently known and assumed predictors...
  42. doi Heart rate regulation and extreme bradycardia in diving emperor penguins
    Jessica U Meir
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
    J Exp Biol 211:1169-79. 2008
    ..In contrast to any other freely diving bird, a true bradycardia (f(H) significantly <f(H) at rest) occurred during diving [dive f(H) (total beats/duration)=57+/-2 beats min(..
  43. doi Repetitive paired stimulation of nasotrigeminal and peripheral chemoreceptor afferents cause progressive potentiation of the diving bradycardia
    Miroslav Rozloznik
    Dept of Neuro and Sensory Physiology, Georg August Univ Humboldtallee 23, 37073 Gottingen, Germany
    Am J Physiol Regul Integr Comp Physiol 296:R80-7. 2009
    Hallmarks of the mammalian diving response are protective apnea and bradycardia. These cardiorespiratory adaptations can be mimicked by stimulation of the trigeminal ethmoidal nerve (EN5) and reflect oxygen-conserving mechanisms during ..
  44. doi Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil?
    Koichi Maruyama
    Department of Anesthesiology, Saitama Medical University International Medical Center, 1397 1 Yamane, Hidaka, Saitama, 350 1298, Japan
    J Anesth 24:293-6. 2010
    This study was conducted to examine whether pretreatment with intravenous atropine could prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil in a prospective randomized ..
  45. ncbi [Relationship between efficacy of electroacupuncture and electroacupuncture stimulation of different acupoints and different tissue layers of acupoint area in hypotension plus bradycardia rats]
    Bin Xu
    Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of the People s Republic of China, Nanjing University of Chinese Medicine, Nanjing 210029, China
    Zhen Ci Yan Jiu 35:422-8. 2010
    ..between the effect of electroacupuncture (EA) and EA of different layer tissues of the acupoint area and different acupoints in upregulating mean arterial pressure (MAP) and heart rate (HR) in hypotension plus bradycardia rats.
  46. ncbi Beneficial effects of biatrial pacing on cardiac function in patients with bradycardia -- tachycardia syndrome
    Katsumi Matsumoto
    Second Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
    Circ J 69:831-6. 2005
    ..Biatrial (BiA) pacing prevents atrial fibrillation. By an unknown mechanism. The purpose of this study was to use Doppler echocardiography to evaluate the hemodynamic effects during BiA pacing...
  47. doi How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures?
    Brian D Moseley
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Epilepsia 51:1219-24. 2010
    ..The purpose of this study was to determine the prevalence and risk factors for ictal hypoxemia (oxygen saturation <90%) and ictal bradycardia (heart rate < second percentile for age) in children during recorded seizures.
  48. doi Dexmedetomidine-associated bradycardia progressing to pulseless electrical activity: case report and review of the literature
    Anthony T Gerlach
    Department of Pharmacy, The Ohio State University Medical Center, Ohio 43210, USA
    Pharmacotherapy 29:1492. 2009
    ..It is a distinctive sedative because it does not cause respiratory depression, but it may cause hypotension and bradycardia. We describe a 74-year-old man who was receiving dexmedetomidine for agitation and experienced progressive ..
  49. doi Biventricular pacing in patients with bradycardia and normal ejection fraction
    Cheuk Man Yu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    N Engl J Med 361:2123-34. 2009
    ..we examined whether biventricular pacing is superior to right ventricular apical pacing in preventing deterioration of left ventricular systolic function and cardiac remodeling in patients with bradycardia and a normal ejection fraction.
  50. ncbi [Torsade de pointes associated with severe bradycardia after induction of general anesthesia]
    Eisuke Hamaguchi
    Department of Anesthesiology, Tokushima University Hospital, Tokushima 770 8503
    Masui 60:1097-100. 2011
    ..Just after induction of anesthesia, sinus bradycardia occurred, and 9 minutes after tracheal intubation, ECG suddenly showed torsade de pointes (TdP) and the ..
  51. ncbi Reflex bradycardia in facial surgery
    D G Stott
    Department of Anaesthetics, Stepping Hill Hospital, Stockport
    Br J Plast Surg 42:595-7. 1989
    ..An awareness of its management can obviate morbidity and mortality. An account of the phenomenon, its treatment and illustrative case histories are presented...
  52. pmc Crisis management during anaesthesia: bradycardia
    L M Watterson
    Sydney Medical Simulation Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Qual Saf Health Care 14:e9. 2005
    b>Bradycardia in association with anaesthesia may have many potential causes and associated conditions, some rare and/or obscure. A prompt appropriate response is important as some homeostatic mechanisms may be impaired under anaesthesia.
  53. ncbi Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control group
    Nathalie Costedoat-Chalumeau
    Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Arthritis Rheum 50:3187-94. 2004
    Aside from congenital heart block (CHB), sinus bradycardia and prolongation of the corrected QT (QTc) interval have been reported in infants born to mothers with anti-SSA antibodies...
  54. doi The effect of electrode placement and pulsewidth on asystole and bradycardia during the electroconvulsive therapy stimulus
    Patrick T Stewart
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Int J Neuropsychopharmacol 14:585-94. 2011
    ..The degree of bradycardia (any slowing of heart rate) and incidence of asystole (absence of heart beats for ≥5 s) during the ECT ..
  55. ncbi Sudden bradycardia
    George Nikolic
    Intensive Care Unit, The Canberra Hospital, Canberra, Australia
    Heart Lung 40:177-9. 2011
  56. ncbi Bradycardia and vecuronium: comparison with alcuronium during cholecystectomy
    C P Morton
    Department of Anaesthetics, Royal Infirmary of Edinburgh
    Br J Anaesth 68:619-20. 1992
    We have compared the incidence of bradycardia in two groups of patients undergoing cholecystectomy...
  57. ncbi Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require ANP receptor
    Lisa M Hunt
    Dept of Biology, Williams College, Williamstown, MA 01267, USA
    Am J Physiol Heart Circ Physiol 287:H1446-51. 2004
    ..Furthermore, circulating ANP levels and data from NPR1(-/-) and NPR3(-/-) mice suggest that the ANP pathway may not be involved in the cardiovascular response to CR...
  58. pmc Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation
    Robert A Rose
    Department of Physiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Circ Arrhythm Electrophysiol 4:733-42. 2011
    ..A major prognostic indicator of survival in patients with CIO is iron-mediated cardiomyopathy characterized by contractile dysfunction and electrical disturbances, including slow heart rate (bradycardia) and heart block.
  59. pmc Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro
    N Herring
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    J Physiol 535:507-18. 2001
    1. We tested the hypothesis that nitric oxide (NO) augments vagal neurotransmission and bradycardia via phosphorylation of presynaptic calcium channels to increase vesicular release of acetylcholine. 2...
  60. ncbi [Therapeutic drug monitoring in perioperative period--management of atrial fibrillation in a patient with bradycardia due to relative overdose of digitalis]
    T Murakawa
    Department of Anesthesiology, Odate Municipal Hospital
    Masui 46:521-4. 1997
    We reported a 79 year old man with preoperative bradycardia due to relative overdose of digitalis prior to undergoing subtotal gastrectomy. The patient had received metildigoxin 0.2 mg...
  61. ncbi Bradycardia and hypotension refractory to ephedrine and atropine treatment: severe autonomic dysfunction with abnormal heart rate variability
    Huei Chi Horng
    Taichung Armed Forces General Hospital, Taiwan, ROC
    Acta Anaesthesiol Taiwan 44:109-12. 2006
    ..here report a 48-year-old male patient with diabetes mellitus who suffered from intraoperative hypotension and bradycardia which did not respond to ephedrine and atropine treatment and eventuated in cardiac arrest...
  62. doi Bradycardia during critical care intubation: mechanisms, significance and atropine
    Peter Jones
    Critical Care Group Portex Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Arch Dis Child 97:139-44. 2012
    b>Bradycardia occurs during the intubation of some critically ill children as a result of vagal stimulation due to hypoxia and/or laryngeal stimulation; such 'stable' bradycardia is accompanied by selective vasoconstriction...
  63. doi Bradycardia and hypotension associated with fomepizole infusion during hemodialysis
    Katherine J Lepik
    BC Drug and Poison Information Centre, Vancouver, British Columbia, Canada
    Clin Toxicol (Phila) 46:570-3. 2008
    We report a case of hypotension and bradycardia associated with intravenous fomepizole infusion.
  64. ncbi The relationship between sinus node dysfunction, bradycardia-mediated atrial remodelling, and post-operative atrial flutter in patients with congenital heart defects
    Natasja M S de Groot
    Eur Heart J 27:2036-7. 2006
  65. ncbi Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart
    Li Lei
    Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Circulation 110:796-802. 2004
    We tested the hypothesis that induction of chronic bradycardia would trigger an upregulation of key growth factors and receptors, which would then lead to angiogenesis and improve coronary reserve in the left ventricle after myocardial ..
  66. ncbi The role of nitric oxide in bradycardia of rats with obstructive cholestasis
    A Nahavandi
    Department of Physiology, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Eur J Pharmacol 411:135-141. 2001
    ..Based on evidence of NO overproduction in cholestasis and also on the existence of bradycardia in cholestatic subjects, this study aimed to evaluate the chronotropic effect of epinephrine in isolated atria ..
  67. doi Oral versus nasal route for placing feeding tubes: no effect on hypoxemia and bradycardia in infants with apnea of prematurity
    Bettina Bohnhorst
    Department of Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany
    Neonatology 98:143-9. 2010
    ..Raised upper airway resistance may be involved in apnea of prematurity (AOP)...
  68. pmc Torsade de pointes associated with bradycardia and takotsubo cardiomyopathy
    Satoshi Kurisu
    Department of Cartdiology, Hiroshima City Hospital, Hiroshima, Japan
    Can J Cardiol 24:640-2. 2008
    Two cases of torsade de pointes associated with bradycardia and takotsubo cardiomyopathy are reported. In both cases, atrioventricular block preceded the occurrence of takotsubo cardiomyopathy...
  69. ncbi Factors influencing apnea and bradycardia of prematurity - implications for neurodevelopment
    F Pillekamp
    Children s Hospital, University of Cologne, Cologne, Germany
    Neonatology 91:155-61. 2007
    Apnea and bradycardia of prematurity (ABP) are possible risks towards damage of the developing brain.
  70. ncbi Hypothermia-induced bradycardia in a neonate receiving dexmedetomidine
    Julia C Finkel
    Department of Anesthesiology and Pain Medicine, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    J Clin Anesth 19:290-2. 2007
    ..After 9 hours, the patient developed bradycardia and profound hypothermia...
  71. ncbi Severe bradycardia in a patient with myasthenia gravis during transurethral ureterolithotripsic procedure under spinal anaesthesia
    S Inoue
    Anaesth Intensive Care 30:387. 2002
  72. ncbi Apnea and bradycardia due to anaphylaxis to tobacco glycoprotein in the infant rabbit
    William M Gershan
    Department of Pediatrics, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 West Wisconsin Avenue, MS 777A, Milwaukee, WI 53226, USA
    Environ Res 94:152-9. 2004
    ..We conclude that some rabbits neonatally sensitized to TGP develop apnea and bradycardia upon further intravenous TGP challenge...
  73. ncbi Bradycardia and desaturation during skin-to-skin care: no relationship to hyperthermia
    Bettina Bohnhorst
    Department of Neonatology and Pediatric Pulmonology, Hannover Medical School, Hannover, Germany
    J Pediatr 145:499-502. 2004
    We recently found increased temperature and increased bradycardia and desaturation during skin-to-skin care (SSC). We wanted to determine if these effects were related.
  74. ncbi Impact of bradycardia on cerebral oxygenation and cerebral blood volume during apnoea in preterm infants
    Gerhard Pichler
    Department of Pediatrics, Division of Neonatology, University of Graz, 8036 Graz, Austria
    Physiol Meas 24:671-80. 2003
    ..The aim of this study was to evaluate the effect of bradycardia (below 80 beats min(-1)) on 'cerebral haemoglobin oxygenation index' (cHbD) and cerebral blood volume (CBV) ..
  75. doi Severe hypertension and bradycardia after dexmedetomidine for radiology sedation in a patient with acute transverse myelitis
    Shailesh Shah
    Paediatr Anaesth 18:681-2. 2008
  76. pmc Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study
    Laura Y Park-Wyllie
    Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
    PLoS Med 6:e1000157. 2009
    ..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients...
  77. pmc Microinjections of alpha-melanocyte stimulating hormone into the nucleus ambiguus of the rat elicit vagally mediated bradycardia
    Vineet C Chitravanshi
    Department of Neurological Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, N J 07103, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1402-11. 2009
    ..Bilateral vagotomy completely abolished alpha-MSH-induced bradycardia. The decreases in HR elicited by alpha-MSH (0.8 mM) were completely blocked by a selective MC4R antagonist...
  78. pmc Transpyloric tube feeding in very low birthweight infants with suspected gastroesophageal reflux: impact on apnea and bradycardia
    W F Malcolm
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    J Perinatol 29:372-5. 2009
    ..was to assess the safety and efficacy of transpyloric tube feeding as a therapeutic option to reduce apnea and bradycardia in hospitalized very low birthweight (VLBW) infants with clinical signs suggestive of gastroesophageal reflux (..
  79. doi Postaortic valve replacement bradycardia induced torsades de pointes
    Alexey Amchentsev
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA
    Angiology 59:111-3. 2008
    ..During hospitalization, she developed episodes of Tdp without any provocable cause. This case highlights the occurrence of Tdp secondary to conduction disturbance caused by aortic valve surgery...
  80. pmc Atomoxetine changes rat's HR response to stress from tachycardia to bradycardia via alterations in autonomic function
    Winston Y Li
    Math, Science and Technology Center at Dunbar High School, Lexington, KY, USA
    Auton Neurosci 154:48-53. 2010
    ..These autonomic consequences are consistent with atomoxetine's anxiolytic and transient sedative effects...
  81. doi The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
    Xiaoyan Qi
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 2:295-304. 2009
    Sustained bradycardia is associated with long-QT syndrome in human beings and causes spontaneous torsades de pointes in rabbits with chronic atrioventricular block (CAVB), at least partly by downregulating delayed-rectifier K(+)-current ..
  82. ncbi Drug induced bradycardia: to pace or not to pace?
    I Eli Ovsyshcher
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pacing Clin Electrophysiol 27:1144-7. 2004
  83. doi Bradycardia and cardiac arrest caused by intramyometrial injection of vasopressin during a laparoscopically assisted myomectomy
    Rutsuko Hobo
    Department of Gynecology, Yotsuya Medical Cube, Sanno Hospital, Tokyo, Japan
    Obstet Gynecol 113:484-6. 2009
    ..05-0.3 units/mL, has been considered to be safe. The use of low-dose vasopressin is not free of side effects, and it can also sometimes cause lethal complications...
  84. ncbi Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations
    Jean Marc Lupoglazoff
    Pediatric Cardiology, Necker Enfants Malades AP HP, Paris, France
    J Am Coll Cardiol 43:826-30. 2004
    ..We hypothesized that neonatal long QT syndrome (LQTS) with 2:1 atrioventricular block (AVB) could be related to HERG mutations...
  85. ncbi Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia
    Eyal Nof
    Heart Institute, Chaim Sheba Medical Center, Tel Hashomer 52621 Israel
    Circulation 116:463-70. 2007
    The hyperpolarization-activated nucleotide-gated channel--HCN4 plays a major role in the diastolic depolarization of sinus atrial node cells. Mutant HCN4 channels have been found to be associated with inherited sinus bradycardia.
  86. ncbi The ictal bradycardia syndrome: localization and lateralization
    Jeffrey W Britton
    Divisions of Epilepsy and Clinical Neurophysiology EEG, Department of Neurology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Epilepsia 47:737-44. 2006
    ..These studies have suggested that ictal bradycardia is most commonly a manifestation of activation of the left temporal and insular cortex...
  87. ncbi Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors
    P Bordier
    Hopital Cardiologique du Haut Leveque, University of Bordeaux, Pessac, France
    Europace 5:429-31. 2003
    ..Pacemaker implantation seemed justified rather than donepezil cessation. More over, it permitted an increase in donepezil dosage...
  88. pmc Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity
    Becky J Proskocil
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Environ Health Perspect 116:381-8. 2008
    ..In support of this hypothesis, we have demonstrated that environmentally relevant concentrations of OPs induce airway hyperreactivity in guinea pigs...
  89. ncbi Reducing unnecessary right ventricular pacing with the managed ventricular pacing mode in patients with sinus node disease and AV block
    Anne M Gillis
    Libin Cardiovascular Institute of Alberta and Department of Cardiovascular Sciences, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    Pacing Clin Electrophysiol 29:697-705. 2006
    ..We evaluated a new pacing algorithm, managed ventricular pacing (MVP) which automatically changes modes between AAI/R and DDD/R in patients receiving pacemakers for symptomatic bradycardia.
  90. doi Bradycardia in neurosurgery
    Amit Agrawal
    Department of Surgery, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, India
    Clin Neurol Neurosurg 110:321-7. 2008
    Cushing reflex' is characterized by the occurrence of hypertension, bradycardia and apnoea secondary to raised increased intracranial pressure (ICP), leading to pressure on and or stretch, or both, of the brainstem...
  91. ncbi Decreased bispectral index as an indicator of syncope before hypotension and bradycardia in two patients with needle phobia
    N N Win
    Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, Japan 113 8549
    Br J Anaesth 91:749-52. 2003
    ..In case 1, the reduction in BIS score occurred during the development of hypotension and bradycardia and may well have been caused by cerebral hypoperfusion...
  92. ncbi Long-term reduction of atrial tachyarrhythmia recurrences in patients paced for bradycardia-tachycardia syndrome
    Luigi Padeletti
    Institute of Internal Medicine and Cardiology, University of Florence, Florence, Italy
    Heart Rhythm 2:1047-57. 2005
    ..Atrial tachyarrhythmias (AT) are considered progressive diseases. Several rhythm control therapies for treatment of AT have been proposed...
  93. ncbi Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart
    Monica Garcia
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Clin Exp Pharmacol Physiol 34:1199-206. 2007
    ..we investigated how alloxan-induced diabetes affects the ability of 5-hydroxytryptamine (5-HT) to modulate bradycardia induced in vivo by electrical stimulation of the vagus nerve in pithed rats...
  94. pmc Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice
    Peiyong Zhai
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Clin Invest 115:3045-56. 2005
    ..Tg-i2m mice developed more severe cardiac hypertrophy and bradycardia coupled with lower cardiac function than Tg-WT mice...
  95. ncbi Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakers
    Alessandro Capucci
    Cardiology Department, Civile Hospital, Piacenza, Italy
    J Am Coll Cardiol 46:1913-20. 2005
    The aim of our study was to evaluate arterial embolism (AE) occurrence rates and predictors in patients suffering from bradycardia and wearing a pacemaker with antitachycardia pacing therapies.
  96. pmc Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart
    M J Killeen
    Physiological Laboratory, University of Cambridge, Cambridge, UK
    Acta Physiol (Oxf) 189:33-46. 2007
    ..Hypokalaemia is associated with a lethal form of ventricular tachycardia (VT), torsade de pointes, through pathophysiological mechanisms requiring clarification...
  97. ncbi Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel
    Raffaella Milanesi
    Department of Biomolecular Sciences and Biotechnology, Laboratory of Molecular Physiology and Neurobiology, University of Milan, Milan, Italy
    N Engl J Med 354:151-7. 2006
    We found that sinus bradycardia in members of a large family was associated with a mutation in the gene coding for the pacemaker HCN4 ion channel...
  98. ncbi Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Pharmacotherapy 25:899-903. 2005
    ..In addition, they should continue to reserve its use for moderate-to-severe Pneumocystis jiroveci pneumonia for which trimethoprim-sulfamethoxazole is ineffective or contraindicated...
  99. ncbi Atropine pretreatment enhances airway hyperreactivity in antigen-challenged guinea pigs through an eosinophil-dependent mechanism
    Norah G Verbout
    1Department of Physiology, Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1126-35. 2007
    ..Thus atropine pretreatment potentiated airway hyperreactivity by increasing eosinophil activation and degranulation. These data suggest that anticholinergics enhance eosinophil interactions with airway nerves...
  100. ncbi Electrocardiographic effects of rivastigmine
    Joel Morganroth
    eResearch Technology, Philadelphia, PA 19103, USA
    J Clin Pharmacol 42:558-68. 2002
    ..Percentage change from baseline for PR, QRS, and QTc intervals was also no different. In conclusion, rivastigmine appears not to produce adverse effects on cardiac function assessed by ECG...
  101. ncbi Recurrent life-threatening bradycardia in a child with retained tracheal stent
    Chung Hau Juan
    Department of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Paediatr Anaesth 15:251-3. 2005
    We report a child with a retained welded tracheal stent scheduled for removal developing refractory bradycardia and cardiac arrest during attempt to remove the stent. Cardiac massage and pacing were necessary to reestablish circulation...

Research Grants71

  1. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs and TdP...
  2. Procedural Pain and Hypoxia in Preterm Neonates
    DANILYN ANGELES; Fiscal Year: 2007
    ..In addition, these procedures are documented to result in bradycardia, systemic hypotension and arterial oxygen desaturation or "hypoxemia"...
  3. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    ..A broader spectrum of autonomic signs, including changes in heart rate and rhythm (most often bradycardia), blood pressure (most often pressure increases), pupillary size, vasomotor and sudomotor activity, GI motility ..
  4. Factors that Initiate Arrhythmias in lung QT Syndrome
    Guy Salama; Fiscal Year: 2004
    ..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs and TdP.
  5. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2000
    ..In these studies isoflurane and propofol depressed the bradycardia that follows MAP increase induced by iv phenyephrine in both intact and decerebrate rats...
  6. CONTROL OF VASCULAR TONE BY CONTINGENT CNS STIMULATION
    Barry Dworkin; Fiscal Year: 1993
    ..rat model to (1) determine if a widely observed, but poorly understood phenomenon, shock conditioned vagal bradycardia, is in reality a case of implicit baroreflex conditioning; (2) verify and extend preliminary evidence that the ..
  7. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
    ..2. To identify sound characteristics in NICUs that disrupt sleep or increase episodes of apnea, bradycardia, or desaturation in ELBW infants...
  8. MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATES
    David Mendelowitz; Fiscal Year: 2011
    The diving reflex is the most powerful autonomic reflex. Stimulation of the diving reflex evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
  9. MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATES
    David Mendelowitz; Fiscal Year: 2010
    The diving reflex is the most powerful autonomic reflex. Stimulation of the diving reflex evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
  10. Characterization of autonomic dysfunction in Rett syndrome and other MECP2 disord
    Jeffrey L Neul; Fiscal Year: 2010
    ..Boys with mutations in MECP2 and congenital encephalopathy have a number of autonomic abnormalities including bradycardia, apnea, and respiratory arrest resulting in death in the first three years of life...
  11. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2009
    ..of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
  12. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2010
    ..of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
  13. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2006
    ..FQ (N/OFQ) is an endogenous opioid-like peptide that produces marked effects on cardiovascular (hypotension, bradycardia, sympathoinhibition) and renal excretory (water diuresis) function in animals...
  14. TRH in mediating the bradycardia of caloric restriction
    Steven Swoap; Fiscal Year: 2005
    ..The overall goal of this proposal is to elucidate the underlying mechanism(s) of the bradycardia induced by the reduction of caloric intake...
  15. Trigeminal Autonomic Interactions
    Paul McCulloch; Fiscal Year: 2002
    ..This reflex includes central apnea, parasympathetic bradycardia and sympathetically mediated vasoconstriction...
  16. PRECISE CONTOL OF TONGUE MOVEMENT
    Stephen Goldberg; Fiscal Year: 2005
    ..Attempts to begin bottle feeding these infants can result in apnea, bradycardia, hypoxia, fatigue and agitation and there can also be the long term consequence of delayed oral feeding ..
  17. Neuroplasticity and the carotid body
    Estelle Gauda; Fiscal Year: 2007
    ..Furthermore, these infants are at high risk for persistent apnea and bradycardia, reduced arousal responses during sleep, and sudden death which are all adverse physiological events related to ..
  18. Neuroplasticity and the carotid body
    Estelle Gauda; Fiscal Year: 2009
    ..Furthermore, these infants are at high risk for persistent apnea and bradycardia, reduced arousal responses during sleep, and sudden death which are all adverse physiological events related to ..
  19. Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neurons
    Eugen Brailoiu; Fiscal Year: 2009
    ..that microinjection of G-1, a specific GPR30 agonist, or 17-estradiol (E2) into the nucleus ambiguus produces bradycardia; the effect was abolished by prior administration of G-36, a GPR30 antagonist...
  20. Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neurons
    Eugen Brailoiu; Fiscal Year: 2009
    ..that microinjection of G-1, a specific GPR30 agonist, or 17-estradiol (E2) into the nucleus ambiguus produces bradycardia; the effect was abolished by prior administration of G-36, a GPR30 antagonist...
  21. Role of Ca channels in congenital heart block
    Mohamed Boutjdir; Fiscal Year: 2007
    ..We have also reported for the first time significant sinus bradycardia unrelated to AV block...
  22. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    RICHARD VEENSTRA; Fiscal Year: 2007
    ..ventricular action potential waveforms at different rates of stimulation ranging from 240 (tachycardia) to 30 (bradycardia) beats/min...
  23. Air Pollution and Cardiorespiratory Events In Infants
    Paige Tolbert; Fiscal Year: 2003
    ..the first of its kind, is to examine the occurrence of cardiorespiratory events (in particular, apnea and bradycardia) in infants on home cardiorespiratory monitors in relation to daily measures of ambient air pollution in the ..