Genomes and Genes
Summary: Excessive slowness in the action of the heart, usually with a heart rate below 60 beats per minute.
Publications321 found, 100 shown here
- Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafnessShahid M Baig
Human Molecular Genetics Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
Nat Neurosci 14:77-84. 2011..We describe a human channelopathy (termed SANDD syndrome, sinoatrial node dysfunction and deafness) with a cardiac and auditory phenotype that closely resembles that of Cacna1d(-/-) mice...
- Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold-Jarisch reflexS M Kinsella
Sir Humphry Davy Department of Anaesthesia, St Michael's Hospital, Bristol, UK
Br J Anaesth 86:859-68. 2001Reflex cardiovascular depression with vasodilation and bradycardia has been variously termed vasovagal syncope, the Bezold-Jarisch reflex and neurocardiogenic syncope...
- Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4Mirko Baruscotti
Department of Biomolecular Sciences and Biotechnology, PaceLab and Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata, Milano, Universita degli Studi di Milano, 20133 Milan, Italy
Proc Natl Acad Sci U S A 108:1705-10. 2011..HCN4 knockout (ciHCN4-KO) mouse model, ablation of HCN4 consistently leads to progressive development of severe bradycardia (∼50% reduction of original rate) and AV block, eventually leading to heart arrest and death in about 5 d...
- Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 familiesMarieke W Veldkamp
Experimental and Molecular Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
Circ Res 92:976-83. 2003..In addition to the characteristic QT prolongation, LQT3 carriers regularly present with bradycardia and sinus pauses...
- Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptorsJohn T Fisher
Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
FASEB J 18:711-3. 2004..ligands, have complicated the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due to vagal innervation...
- Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patientsA V Postma
J Med Genet 42:863-70. 2005..The aim of the study was to assess underlying genetic cause(s), clinical features, and response to therapy in catecholaminergic polymorphic ventricular tachycardia (CPVT) probands...
- Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardiaAtsunori Kamiya
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1 Hujishirodai, Suita, Osaka 565 8565, Japan
Am J Physiol Heart Circ Physiol 289:H1758-69. 2005..LF oscillation of MSNA variability decreased during development of orthostatic neurally mediated syncope, preceding sympathetic withdrawal, bradycardia, and severe hypotension, to the level at syncope.
- Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardiaYongxia Qu
VA New York Harbor Healthcare System, New York, NY, USA
Circulation 111:3034-41. 2005..Although the hallmark of CHB is complete atrioventricular block, sinus bradycardia has been reported recently in animal models of CHB...
- Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heartRie Schultz Hansen
Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
J Pharmacol Exp Ther 321:996-1002. 2007..Taken together, the present data strongly support the concept of using hERG activators as a treatment for certain kinds of arrhythmias and suggest further investigation of this new approach...
- Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channelsMatteo E Mangoni
Institut de Genomique Fonctionnelle, CNRS UMR5203 INSERM U661, Departement de Physiologie, Universite de Montpellier I, Montpellier Cedex 05, F 34094, France
Circ Res 98:1422-30. 2006..electrocardiograms on unrestrained mice and intracardiac recordings, we find that cacna1g inactivation causes bradycardia and delays atrioventricular conduction without affecting the excitability of the right atrium...
- Cholinesterase inhibitors and incidence of bradycardia in patients with dementia in the veterans affairs new England healthcare systemRohini K Hernandez
Cooperative Studies Program, Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
J Am Geriatr Soc 57:1997-2003. 2009To quantify the association between cholinesterase inhibitors (ChE-Is) and a new diagnosis of bradycardia and to evaluate the clinical significance of bradycardia.
- The development of diving bradycardia in bottlenose dolphins (Tursiops truncatus)S R Noren
Ecology and Evolutionary Biology Department, Center for Ocean Health, University of California, Santa Cruz, CA 95060, USA
J Comp Physiol B 174:139-47. 2004b>Bradycardia is an important component of the dive response, yet little is known about this response in immature marine mammals...
- Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathwayNeil Herring
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford University OX1 3PT, UK
J Mol Cell Cardiol 44:477-85. 2008..Y (NPY), released during prolonged cardiac sympathetic nerve stimulation, can attenuate vagal-induced bradycardia. We tested the hypothesis that NPY reduces acetylcholine release, at similar concentrations to which it ..
- Bradycardia leading to asystole during dexmedetomidine infusion in an 18 year-old double-lung transplant recipientXiaopeng Zhang
Division of Anesthesiology, Geisinger Medical Center, Danville, PA 17821, USA
J Clin Anesth 22:45-9. 2010..transplant recipient recovering from acute respiratory distress syndrome who developed repeated episodes of bradycardia and asystole (maximum duration: 10 sec) during dexmedetomidine administration is presented...
- Cardiac effects of amodiaquine and sulfadoxine-pyrimethamine in malaria-infected African patientsB Ngouesse
, , , Cameroon
Am J Trop Med Hyg 65:711-6. 2001..Clinical and parasitological responses were monitored until Day 14. Bradycardia was observed in 16 of 20 amodiaquine-treated patients on Day 2, which corresponds to the time when maximal ..
- Pediatric rapid sequence intubation: incidence of reflex bradycardia and effects of pretreatment with atropineRebecca K Fastle
Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center and The Children s Hospital, Denver, CO, USA
Pediatr Emerg Care 20:651-5. 2004The American College of Emergency Physicians (ACEP) recommends atropine as adjunctive therapy to prevent reflex bradycardia prior to laryngoscopy/tracheal intubation (L/TI) in pediatric patients.
- Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changesYukiomi Tsuji
Research Center, Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
Circulation 113:345-55. 2006..Uncontrolled tachycardia produces heart failure and ventricular tachyarrhythmia susceptibility, whereas bradycardia promotes spontaneous torsade de pointes (TdP)...
- Fetal bradycardia and disseminated coagulopathy: atypical presentation of amniotic fluid emboliR Levy
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel
Acta Anaesthesiol Scand 48:1214-5. 2004We present a parturient who developed an atypical case of amniotic fluid emboli presented by sudden fetal bradycardia, followed by maternal disseminated coagulopathy...
- Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardiaLuiza Michelle Cangussu
Departamento de Ciencias Biologicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil
Peptides 30:1921-7. 2009..and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C)...
- Hypotension, bradycardia and syncope caused by honey poisoningOzcan Yilmaz
Ondokuz Mayis University School of Medicine, Department of Cardiology, Kurupelit, Samsun, Turkey
Resuscitation 68:405-8. 2006..with a variety of symptoms including nausea, vomiting, salivation, dizziness, weakness, hypotension, bradycardia and syncope several hours after the ingestion of small amounts of honey...
- Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibitionBoyoung Joung
Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University Schoolof Medicine, Indianapolis, Indiana 46202, USA
Am J Physiol Heart Circ Physiol 299:H634-42. 2010..Combined malfunction of both membrane and Ca(2+) clocks underlies the mechanisms of PSPs...
- Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA releaseT Kishi
Department of Cardiovascular Medicine, Cardiovascular Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hypertension 38:896-901. 2001..Furthermore, these responses may be mediated by an increased release of GABA in the RVLM...
- Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking developmentRudiger J Blaschke
Human Genetics, University of Heidelberg, Heidelberg, Germany
Circulation 115:1830-8. 2007..Here, we report on a highly restricted expression pattern of the homeodomain transcription factor Shox2 in the sinus venosus myocardium, including the sinoatrial nodal region and the venous valves...
- Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 womenA Brucato
Niguarda Hospital, Milan, Italy
Arthritis Rheum 44:1832-5. 2001..In 2 centers, electrocardiography was recorded in 24 unselected newborns, and 4 were found to have sinus bradycardia. CONCLUSION: The prevalence of CCHB in newborns of prospectively followed up women already known to be anti-Ro/..
- Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinibSai Hong Ignatius Ou
Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, California 92868 3298, USA
J Thorac Oncol 6:2135-7. 2011..We have observed several patients who developed profound but asymptomatic sinus bradycardia (HR ≤45) during the course of crizotinib treatment...
- Carotid angioplasty and stent-induced bradycardia and hypotension: Impact of prophylactic atropine administration and prior carotid endarterectomyNeal S Cayne
Department of Vascular Surgery, New York University Medical Center, NY 10016, USA
J Vasc Surg 41:956-61. 2005We compared the physiologic effect of selective atropine administration for bradycardia with routine prophylactic administration, before balloon inflation, during carotid angioplasty and stenting (CAS)...
- Apnea, bradycardia and desaturation in preterm infants before and after feedingC Slocum
Carillion Roanoke Community Hospital, Roanoke, VA, USA
J Perinatol 29:209-12. 2009..We aimed to measure objectively the effects of feeding on GER, apnea, bradycardia and desaturations.
- Reflex bradycardia during surgeryD J Doyle
Department of Anaesthesia, Toronto General Hospital, Ontario
Can J Anaesth 37:219-22. 1990Reflex bradycardia and sinus arrest may occur in a variety of surgical procedures, from neurosurgery to general abdominal, laparoscopic, ophthalmic and facial surgery and even procedures such as liver biopsies and electroconvulsive ..
- Drugs that induce repolarization abnormalities cause bradycardia in zebrafishDavid J Milan
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston 02129, USA
Circulation 107:1355-8. 2003..Current in vitro preclinical assays are limited by biological simplicity, and in vivo models suffer from expense and low throughput...
- Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndromeColleen E Clancy
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Clin Invest 110:1251-62. 2002..These results link mutation-induced changes in Na+ channel gating mode transitions to heart rate-dependent changes in cellular electrical activity underlying a key LQT-3 clinical phenotype...
- Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious ratsGregg R Ward
Department of Pharmacology, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
BMC Pharmacol 6:2. 2006Previous studies have shown that testosterone enhances baroreflex bradycardia. Therefore, conscious unrestrained rats were used to investigate the role of the androgen receptor in the testosterone-mediated modulation of baroreflex ..
- Assessment of atrial regional wall motion using strain Doppler imaging during biatrial pacing in the bradycardia-tachycardia syndromeKatsumi Matsumoto
Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
Pacing Clin Electrophysiol 29:220-5. 2006..Biatrial pacing is expected to have preventive effects on atrial fibrillation...
- Bradycardia due to hydrogen peroxide irrigation during craniotomy for craniopharyngiomaHemanshu Prabhakar
Department of Neuroanesthesiology, All India Institute of Medical Sciences, New Delhi 110029, India
J Clin Neurosci 14:488-90. 2007..A sudden bradycardia occurred after instillation of hydrogen peroxide solution at the surgical site...
- Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotensionN R Keller
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, AA3228 MCN, Nashville, TN 37232 2195, USA
Neuroscience 139:931-46. 2006..Upon placement in the behavioral chamber, norepinephrine transporter-deficient mice demonstrated a notable bradycardia and depressor effect that was more pronounced in females...
- Changes in left ventricular repolarization and ion channel currents following a transient rate increase superimposed on bradycardia in anesthetized dogsM Rubart
Department of Medicine, Indiana University School of Medicine, Krannert Institute of Cardiology, Indianapolis 46202 4800, USA
J Cardiovasc Electrophysiol 11:652-64. 2000We previously demonstrated in dogs that a transient rate increase superimposed on bradycardia causes prolongation of ventricular refractoriness that persists for hours after resumption of bradycardia...
- GABAergic neurotransmission at the nucleus tractus solitarii in the suppression of reflex bradycardia by parabrachial nucleusW B Len
Team of Biomedical Science, Chang-Gung Institute of Nursing, Taoyuan, Taiwan
Synapse 42:27-39. 2001..These results suggest that a direct GABAergic descending projection from the KF subnucleus and surrounding areas of the PBN complex to the NTS may inhibit cardiac BRR response by activating GABA(A) and GABA(B) receptors at the NTS...
- Does heart rate variability predict hypotension and bradycardia after induction of general anaesthesia in high risk cardiovascular patients?R Hanss
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
Anaesthesia 63:129-35. 2008..measurement of heart rate variability and were then assigned according to haemodynamic events (hypotension or bradycardia) after standardised induction of anaesthesia into 'stable' (n = 39) and 'unstable' patients (n = 11)...
- Prolonged and symptomatic bradycardia following a single dose of fingolimodHans Faber
Neurology, Max Planck Institute of Psychiatry, Munich, Germany
Mult Scler 19:126-8. 2013Fingolimod-related bradycardia is usually asymptomatic, reaches its nadir within 6 hours post-dose and recovers spontaneously...
- Asystole and bradycardia related to anesthetic induction during ECT: a case reportMark J Russ
J ECT 20:195-7. 2004
- Severe bradycardia after anesthesia before electroconvulsive therapyTom K Birkenhager
Departments of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
J ECT 26:53-4. 2010Postanesthesia bradycardia or asystole before electroconvulsive therapy (ECT) occurs very infrequently but is a potentially fatal complication of pre-ECT anesthesia...
- Predictors of bradycardia during the stimulation phase of electroconvulsive therapyJosef Nagler
Christophsbad Clinic, Goppingen, Germany
J ECT 27:201-6. 2011..Temporary asystole can be detected at various time points during electroconvulsive treatment. We carefully monitored and documented its incidence during stimulation to evaluate currently known and assumed predictors...
- Heart rate regulation and extreme bradycardia in diving emperor penguinsJessica U Meir
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
J Exp Biol 211:1169-79. 2008..In contrast to any other freely diving bird, a true bradycardia (f(H) significantly <f(H) at rest) occurred during diving [dive f(H) (total beats/duration)=57+/-2 beats min(..
- Repetitive paired stimulation of nasotrigeminal and peripheral chemoreceptor afferents cause progressive potentiation of the diving bradycardiaMiroslav Rozloznik
Dept of Neuro and Sensory Physiology, Georg August Univ Humboldtallee 23, 37073 Gottingen, Germany
Am J Physiol Regul Integr Comp Physiol 296:R80-7. 2009Hallmarks of the mammalian diving response are protective apnea and bradycardia. These cardiorespiratory adaptations can be mimicked by stimulation of the trigeminal ethmoidal nerve (EN5) and reflect oxygen-conserving mechanisms during ..
- Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil?Koichi Maruyama
Department of Anesthesiology, Saitama Medical University International Medical Center, 1397 1 Yamane, Hidaka, Saitama, 350 1298, Japan
J Anesth 24:293-6. 2010This study was conducted to examine whether pretreatment with intravenous atropine could prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil in a prospective randomized ..
- [Relationship between efficacy of electroacupuncture and electroacupuncture stimulation of different acupoints and different tissue layers of acupoint area in hypotension plus bradycardia rats]Bin Xu
Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of the People s Republic of China, Nanjing University of Chinese Medicine, Nanjing 210029, China
Zhen Ci Yan Jiu 35:422-8. 2010..between the effect of electroacupuncture (EA) and EA of different layer tissues of the acupoint area and different acupoints in upregulating mean arterial pressure (MAP) and heart rate (HR) in hypotension plus bradycardia rats.
- Beneficial effects of biatrial pacing on cardiac function in patients with bradycardia -- tachycardia syndromeKatsumi Matsumoto
Second Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
Circ J 69:831-6. 2005..Biatrial (BiA) pacing prevents atrial fibrillation. By an unknown mechanism. The purpose of this study was to use Doppler echocardiography to evaluate the hemodynamic effects during BiA pacing...
- How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures?Brian D Moseley
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Epilepsia 51:1219-24. 2010..The purpose of this study was to determine the prevalence and risk factors for ictal hypoxemia (oxygen saturation <90%) and ictal bradycardia (heart rate < second percentile for age) in children during recorded seizures.
- Dexmedetomidine-associated bradycardia progressing to pulseless electrical activity: case report and review of the literatureAnthony T Gerlach
Department of Pharmacy, The Ohio State University Medical Center, Ohio 43210, USA
Pharmacotherapy 29:1492. 2009..It is a distinctive sedative because it does not cause respiratory depression, but it may cause hypotension and bradycardia. We describe a 74-year-old man who was receiving dexmedetomidine for agitation and experienced progressive ..
- Biventricular pacing in patients with bradycardia and normal ejection fractionCheuk Man Yu
Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
N Engl J Med 361:2123-34. 2009..we examined whether biventricular pacing is superior to right ventricular apical pacing in preventing deterioration of left ventricular systolic function and cardiac remodeling in patients with bradycardia and a normal ejection fraction.
- [Torsade de pointes associated with severe bradycardia after induction of general anesthesia]Eisuke Hamaguchi
Department of Anesthesiology, Tokushima University Hospital, Tokushima 770 8503
Masui 60:1097-100. 2011..Just after induction of anesthesia, sinus bradycardia occurred, and 9 minutes after tracheal intubation, ECG suddenly showed torsade de pointes (TdP) and the ..
- Reflex bradycardia in facial surgeryD G Stott
Department of Anaesthetics, Stepping Hill Hospital, Stockport
Br J Plast Surg 42:595-7. 1989..An awareness of its management can obviate morbidity and mortality. An account of the phenomenon, its treatment and illustrative case histories are presented...
- Crisis management during anaesthesia: bradycardiaL M Watterson
Sydney Medical Simulation Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia
Qual Saf Health Care 14:e9. 2005b>Bradycardia in association with anaesthesia may have many potential causes and associated conditions, some rare and/or obscure. A prompt appropriate response is important as some homeostatic mechanisms may be impaired under anaesthesia.
- Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control groupNathalie Costedoat-Chalumeau
Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Arthritis Rheum 50:3187-94. 2004Aside from congenital heart block (CHB), sinus bradycardia and prolongation of the corrected QT (QTc) interval have been reported in infants born to mothers with anti-SSA antibodies...
- The effect of electrode placement and pulsewidth on asystole and bradycardia during the electroconvulsive therapy stimulusPatrick T Stewart
School of Psychiatry, University of New South Wales, Sydney, Australia
Int J Neuropsychopharmacol 14:585-94. 2011..The degree of bradycardia (any slowing of heart rate) and incidence of asystole (absence of heart beats for ≥5 s) during the ECT ..
- Sudden bradycardiaGeorge Nikolic
Intensive Care Unit, The Canberra Hospital, Canberra, Australia
Heart Lung 40:177-9. 2011
- Bradycardia and vecuronium: comparison with alcuronium during cholecystectomyC P Morton
Department of Anaesthetics, Royal Infirmary of Edinburgh
Br J Anaesth 68:619-20. 1992We have compared the incidence of bradycardia in two groups of patients undergoing cholecystectomy...
- Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require ANP receptorLisa M Hunt
Dept of Biology, Williams College, Williamstown, MA 01267, USA
Am J Physiol Heart Circ Physiol 287:H1446-51. 2004..Furthermore, circulating ANP levels and data from NPR1(-/-) and NPR3(-/-) mice suggest that the ANP pathway may not be involved in the cardiovascular response to CR...
- Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillationRobert A Rose
Department of Physiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Circ Arrhythm Electrophysiol 4:733-42. 2011..A major prognostic indicator of survival in patients with CIO is iron-mediated cardiomyopathy characterized by contractile dysfunction and electrical disturbances, including slow heart rate (bradycardia) and heart block.
- Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitroN Herring
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
J Physiol 535:507-18. 20011. We tested the hypothesis that nitric oxide (NO) augments vagal neurotransmission and bradycardia via phosphorylation of presynaptic calcium channels to increase vesicular release of acetylcholine. 2...
- [Therapeutic drug monitoring in perioperative period--management of atrial fibrillation in a patient with bradycardia due to relative overdose of digitalis]T Murakawa
Department of Anesthesiology, Odate Municipal Hospital
Masui 46:521-4. 1997We reported a 79 year old man with preoperative bradycardia due to relative overdose of digitalis prior to undergoing subtotal gastrectomy. The patient had received metildigoxin 0.2 mg...
- Bradycardia and hypotension refractory to ephedrine and atropine treatment: severe autonomic dysfunction with abnormal heart rate variabilityHuei Chi Horng
Taichung Armed Forces General Hospital, Taiwan, ROC
Acta Anaesthesiol Taiwan 44:109-12. 2006..here report a 48-year-old male patient with diabetes mellitus who suffered from intraoperative hypotension and bradycardia which did not respond to ephedrine and atropine treatment and eventuated in cardiac arrest...
- Bradycardia during critical care intubation: mechanisms, significance and atropinePeter Jones
Critical Care Group Portex Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
Arch Dis Child 97:139-44. 2012b>Bradycardia occurs during the intubation of some critically ill children as a result of vagal stimulation due to hypoxia and/or laryngeal stimulation; such 'stable' bradycardia is accompanied by selective vasoconstriction...
- Bradycardia and hypotension associated with fomepizole infusion during hemodialysisKatherine J Lepik
BC Drug and Poison Information Centre, Vancouver, British Columbia, Canada
Clin Toxicol (Phila) 46:570-3. 2008We report a case of hypotension and bradycardia associated with intravenous fomepizole infusion.
- The relationship between sinus node dysfunction, bradycardia-mediated atrial remodelling, and post-operative atrial flutter in patients with congenital heart defectsNatasja M S de Groot
Eur Heart J 27:2036-7. 2006
- Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heartLi Lei
Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Circulation 110:796-802. 2004We tested the hypothesis that induction of chronic bradycardia would trigger an upregulation of key growth factors and receptors, which would then lead to angiogenesis and improve coronary reserve in the left ventricle after myocardial ..
- The role of nitric oxide in bradycardia of rats with obstructive cholestasisA Nahavandi
Department of Physiology, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
Eur J Pharmacol 411:135-141. 2001..Based on evidence of NO overproduction in cholestasis and also on the existence of bradycardia in cholestatic subjects, this study aimed to evaluate the chronotropic effect of epinephrine in isolated atria ..
- Oral versus nasal route for placing feeding tubes: no effect on hypoxemia and bradycardia in infants with apnea of prematurityBettina Bohnhorst
Department of Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany
Neonatology 98:143-9. 2010..Raised upper airway resistance may be involved in apnea of prematurity (AOP)...
- Torsade de pointes associated with bradycardia and takotsubo cardiomyopathySatoshi Kurisu
Department of Cartdiology, Hiroshima City Hospital, Hiroshima, Japan
Can J Cardiol 24:640-2. 2008Two cases of torsade de pointes associated with bradycardia and takotsubo cardiomyopathy are reported. In both cases, atrioventricular block preceded the occurrence of takotsubo cardiomyopathy...
- Factors influencing apnea and bradycardia of prematurity - implications for neurodevelopmentF Pillekamp
Children s Hospital, University of Cologne, Cologne, Germany
Neonatology 91:155-61. 2007Apnea and bradycardia of prematurity (ABP) are possible risks towards damage of the developing brain.
- Hypothermia-induced bradycardia in a neonate receiving dexmedetomidineJulia C Finkel
Department of Anesthesiology and Pain Medicine, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
J Clin Anesth 19:290-2. 2007..After 9 hours, the patient developed bradycardia and profound hypothermia...
- Severe bradycardia in a patient with myasthenia gravis during transurethral ureterolithotripsic procedure under spinal anaesthesiaS Inoue
Anaesth Intensive Care 30:387. 2002
- Apnea and bradycardia due to anaphylaxis to tobacco glycoprotein in the infant rabbitWilliam M Gershan
Department of Pediatrics, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 West Wisconsin Avenue, MS 777A, Milwaukee, WI 53226, USA
Environ Res 94:152-9. 2004..We conclude that some rabbits neonatally sensitized to TGP develop apnea and bradycardia upon further intravenous TGP challenge...
- Bradycardia and desaturation during skin-to-skin care: no relationship to hyperthermiaBettina Bohnhorst
Department of Neonatology and Pediatric Pulmonology, Hannover Medical School, Hannover, Germany
J Pediatr 145:499-502. 2004We recently found increased temperature and increased bradycardia and desaturation during skin-to-skin care (SSC). We wanted to determine if these effects were related.
- Impact of bradycardia on cerebral oxygenation and cerebral blood volume during apnoea in preterm infantsGerhard Pichler
Department of Pediatrics, Division of Neonatology, University of Graz, 8036 Graz, Austria
Physiol Meas 24:671-80. 2003..The aim of this study was to evaluate the effect of bradycardia (below 80 beats min(-1)) on 'cerebral haemoglobin oxygenation index' (cHbD) and cerebral blood volume (CBV) ..
- Severe hypertension and bradycardia after dexmedetomidine for radiology sedation in a patient with acute transverse myelitisShailesh Shah
Paediatr Anaesth 18:681-2. 2008
- Cholinesterase inhibitors and hospitalization for bradycardia: a population-based studyLaura Y Park-Wyllie
Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
PLoS Med 6:e1000157. 2009..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients...
- Microinjections of alpha-melanocyte stimulating hormone into the nucleus ambiguus of the rat elicit vagally mediated bradycardiaVineet C Chitravanshi
Department of Neurological Surgery, University of Medicine and Dentistry New Jersey Medical School, Newark, N J 07103, USA
Am J Physiol Regul Integr Comp Physiol 296:R1402-11. 2009..Bilateral vagotomy completely abolished alpha-MSH-induced bradycardia. The decreases in HR elicited by alpha-MSH (0.8 mM) were completely blocked by a selective MC4R antagonist...
- Transpyloric tube feeding in very low birthweight infants with suspected gastroesophageal reflux: impact on apnea and bradycardiaW F Malcolm
Department of Pediatrics, Duke University, Durham, NC 27710, USA
J Perinatol 29:372-5. 2009..was to assess the safety and efficacy of transpyloric tube feeding as a therapeutic option to reduce apnea and bradycardia in hospitalized very low birthweight (VLBW) infants with clinical signs suggestive of gastroesophageal reflux (..
- Postaortic valve replacement bradycardia induced torsades de pointesAlexey Amchentsev
Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA
Angiology 59:111-3. 2008..During hospitalization, she developed episodes of Tdp without any provocable cause. This case highlights the occurrence of Tdp secondary to conduction disturbance caused by aortic valve surgery...
- Atomoxetine changes rat's HR response to stress from tachycardia to bradycardia via alterations in autonomic functionWinston Y Li
Math, Science and Technology Center at Dunbar High School, Lexington, KY, USA
Auton Neurosci 154:48-53. 2010..These autonomic consequences are consistent with atomoxetine's anxiolytic and transient sedative effects...
- The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndromeXiaoyan Qi
Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
Circ Arrhythm Electrophysiol 2:295-304. 2009Sustained bradycardia is associated with long-QT syndrome in human beings and causes spontaneous torsades de pointes in rabbits with chronic atrioventricular block (CAVB), at least partly by downregulating delayed-rectifier K(+)-current ..
- Drug induced bradycardia: to pace or not to pace?I Eli Ovsyshcher
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pacing Clin Electrophysiol 27:1144-7. 2004
- Bradycardia and cardiac arrest caused by intramyometrial injection of vasopressin during a laparoscopically assisted myomectomyRutsuko Hobo
Department of Gynecology, Yotsuya Medical Cube, Sanno Hospital, Tokyo, Japan
Obstet Gynecol 113:484-6. 2009..05-0.3 units/mL, has been considered to be safe. The use of low-dose vasopressin is not free of side effects, and it can also sometimes cause lethal complications...
- Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutationsJean Marc Lupoglazoff
Pediatric Cardiology, Necker Enfants Malades AP HP, Paris, France
J Am Coll Cardiol 43:826-30. 2004..We hypothesized that neonatal long QT syndrome (LQTS) with 2:1 atrioventricular block (AVB) could be related to HERG mutations...
- Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardiaEyal Nof
Heart Institute, Chaim Sheba Medical Center, Tel Hashomer 52621 Israel
Circulation 116:463-70. 2007The hyperpolarization-activated nucleotide-gated channel--HCN4 plays a major role in the diastolic depolarization of sinus atrial node cells. Mutant HCN4 channels have been found to be associated with inherited sinus bradycardia.
- The ictal bradycardia syndrome: localization and lateralizationJeffrey W Britton
Divisions of Epilepsy and Clinical Neurophysiology EEG, Department of Neurology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
Epilepsia 47:737-44. 2006..These studies have suggested that ictal bradycardia is most commonly a manifestation of activation of the left temporal and insular cortex...
- Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitorsP Bordier
Hopital Cardiologique du Haut Leveque, University of Bordeaux, Pessac, France
Europace 5:429-31. 2003..Pacemaker implantation seemed justified rather than donepezil cessation. More over, it permitted an increase in donepezil dosage...
- Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivityBecky J Proskocil
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
Environ Health Perspect 116:381-8. 2008..In support of this hypothesis, we have demonstrated that environmentally relevant concentrations of OPs induce airway hyperreactivity in guinea pigs...
- Reducing unnecessary right ventricular pacing with the managed ventricular pacing mode in patients with sinus node disease and AV blockAnne M Gillis
Libin Cardiovascular Institute of Alberta and Department of Cardiovascular Sciences, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
Pacing Clin Electrophysiol 29:697-705. 2006..We evaluated a new pacing algorithm, managed ventricular pacing (MVP) which automatically changes modes between AAI/R and DDD/R in patients receiving pacemakers for symptomatic bradycardia.
- Bradycardia in neurosurgeryAmit Agrawal
Department of Surgery, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, India
Clin Neurol Neurosurg 110:321-7. 2008Cushing reflex' is characterized by the occurrence of hypertension, bradycardia and apnoea secondary to raised increased intracranial pressure (ICP), leading to pressure on and or stretch, or both, of the brainstem...
- Decreased bispectral index as an indicator of syncope before hypotension and bradycardia in two patients with needle phobiaN N Win
Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, Japan 113 8549
Br J Anaesth 91:749-52. 2003..In case 1, the reduction in BIS score occurred during the development of hypotension and bradycardia and may well have been caused by cerebral hypoperfusion...
- Long-term reduction of atrial tachyarrhythmia recurrences in patients paced for bradycardia-tachycardia syndromeLuigi Padeletti
Institute of Internal Medicine and Cardiology, University of Florence, Florence, Italy
Heart Rhythm 2:1047-57. 2005..Atrial tachyarrhythmias (AT) are considered progressive diseases. Several rhythm control therapies for treatment of AT have been proposed...
- Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heartMonica Garcia
Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
Clin Exp Pharmacol Physiol 34:1199-206. 2007..we investigated how alloxan-induced diabetes affects the ability of 5-hydroxytryptamine (5-HT) to modulate bradycardia induced in vivo by electrical stimulation of the vagus nerve in pithed rats...
- Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic micePeiyong Zhai
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
J Clin Invest 115:3045-56. 2005..Tg-i2m mice developed more severe cardiac hypertrophy and bradycardia coupled with lower cardiac function than Tg-WT mice...
- Monitored atrial fibrillation duration predicts arterial embolic events in patients suffering from bradycardia and atrial fibrillation implanted with antitachycardia pacemakersAlessandro Capucci
Cardiology Department, Civile Hospital, Piacenza, Italy
J Am Coll Cardiol 46:1913-20. 2005The aim of our study was to evaluate arterial embolism (AE) occurrence rates and predictors in patients suffering from bradycardia and wearing a pacemaker with antitachycardia pacing therapies.
- Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heartM J Killeen
Physiological Laboratory, University of Cambridge, Cambridge, UK
Acta Physiol (Oxf) 189:33-46. 2007..Hypokalaemia is associated with a lethal form of ventricular tachycardia (VT), torsade de pointes, through pathophysiological mechanisms requiring clarification...
- Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channelRaffaella Milanesi
Department of Biomolecular Sciences and Biotechnology, Laboratory of Molecular Physiology and Neurobiology, University of Milan, Milan, Italy
N Engl J Med 354:151-7. 2006We found that sinus bradycardia in members of a large family was associated with a mutation in the gene coding for the pacemaker HCN4 ion channel...
- Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literatureTony Antoniou
Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Pharmacotherapy 25:899-903. 2005..In addition, they should continue to reserve its use for moderate-to-severe Pneumocystis jiroveci pneumonia for which trimethoprim-sulfamethoxazole is ineffective or contraindicated...
- Atropine pretreatment enhances airway hyperreactivity in antigen-challenged guinea pigs through an eosinophil-dependent mechanismNorah G Verbout
1Department of Physiology, Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
Am J Physiol Lung Cell Mol Physiol 292:L1126-35. 2007..Thus atropine pretreatment potentiated airway hyperreactivity by increasing eosinophil activation and degranulation. These data suggest that anticholinergics enhance eosinophil interactions with airway nerves...
- Electrocardiographic effects of rivastigmineJoel Morganroth
eResearch Technology, Philadelphia, PA 19103, USA
J Clin Pharmacol 42:558-68. 2002..Percentage change from baseline for PR, QRS, and QTc intervals was also no different. In conclusion, rivastigmine appears not to produce adverse effects on cardiac function assessed by ECG...
- Recurrent life-threatening bradycardia in a child with retained tracheal stentChung Hau Juan
Department of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
Paediatr Anaesth 15:251-3. 2005We report a child with a retained welded tracheal stent scheduled for removal developing refractory bradycardia and cardiac arrest during attempt to remove the stent. Cardiac massage and pacing were necessary to reestablish circulation...
- Factors that Initiate Arrhythamias in Long QT SyndromeGuy Salama; Fiscal Year: 2006..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs and TdP...
- Procedural Pain and Hypoxia in Preterm NeonatesDANILYN ANGELES; Fiscal Year: 2007..In addition, these procedures are documented to result in bradycardia, systemic hypotension and arterial oxygen desaturation or "hypoxemia"...
- Autonomic consequences of brief seizuresMark Stewart; Fiscal Year: 2004..A broader spectrum of autonomic signs, including changes in heart rate and rhythm (most often bradycardia), blood pressure (most often pressure increases), pupillary size, vasomotor and sudomotor activity, GI motility ..
- Factors that Initiate Arrhythmias in lung QT SyndromeGuy Salama; Fiscal Year: 2004..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs and TdP.
- CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTIONMICHAEL ANDRESEN; Fiscal Year: 2000..In these studies isoflurane and propofol depressed the bradycardia that follows MAP increase induced by iv phenyephrine in both intact and decerebrate rats...
- CONTROL OF VASCULAR TONE BY CONTINGENT CNS STIMULATIONBarry Dworkin; Fiscal Year: 1993..rat model to (1) determine if a widely observed, but poorly understood phenomenon, shock conditioned vagal bradycardia, is in reality a case of implicit baroreflex conditioning; (2) verify and extend preliminary evidence that the ..
- Effects of Noise on Newborns < 1000g BirthweightRobert Lasky; Fiscal Year: 2007..2. To identify sound characteristics in NICUs that disrupt sleep or increase episodes of apnea, bradycardia, or desaturation in ELBW infants...
- MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATESDavid Mendelowitz; Fiscal Year: 2011The diving reflex is the most powerful autonomic reflex. Stimulation of the diving reflex evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
- MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATESDavid Mendelowitz; Fiscal Year: 2010The diving reflex is the most powerful autonomic reflex. Stimulation of the diving reflex evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
- Characterization of autonomic dysfunction in Rett syndrome and other MECP2 disordJeffrey L Neul; Fiscal Year: 2010..Boys with mutations in MECP2 and congenital encephalopathy have a number of autonomic abnormalities including bradycardia, apnea, and respiratory arrest resulting in death in the first three years of life...
- Nicotine Modulation of Parasympathetic Cardiac NeuronsDavid Mendelowitz; Fiscal Year: 2009..of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
- Nicotine Modulation of Parasympathetic Cardiac NeuronsDavid Mendelowitz; Fiscal Year: 2010..of the diving reflex by exposing the nasal mucosa to water or air-borne chemical irritants evokes a pronounced bradycardia with heart rate decreasing up to 51% upon a single facial submersion...
- Cardio-renal actions of novel nociceptin analoguesDANIEL KAPUSTA; Fiscal Year: 2006..FQ (N/OFQ) is an endogenous opioid-like peptide that produces marked effects on cardiovascular (hypotension, bradycardia, sympathoinhibition) and renal excretory (water diuresis) function in animals...
- TRH in mediating the bradycardia of caloric restrictionSteven Swoap; Fiscal Year: 2005..The overall goal of this proposal is to elucidate the underlying mechanism(s) of the bradycardia induced by the reduction of caloric intake...
- Trigeminal Autonomic InteractionsPaul McCulloch; Fiscal Year: 2002..This reflex includes central apnea, parasympathetic bradycardia and sympathetically mediated vasoconstriction...
- PRECISE CONTOL OF TONGUE MOVEMENTStephen Goldberg; Fiscal Year: 2005..Attempts to begin bottle feeding these infants can result in apnea, bradycardia, hypoxia, fatigue and agitation and there can also be the long term consequence of delayed oral feeding ..
- Neuroplasticity and the carotid bodyEstelle Gauda; Fiscal Year: 2007..Furthermore, these infants are at high risk for persistent apnea and bradycardia, reduced arousal responses during sleep, and sudden death which are all adverse physiological events related to ..
- Neuroplasticity and the carotid bodyEstelle Gauda; Fiscal Year: 2009..Furthermore, these infants are at high risk for persistent apnea and bradycardia, reduced arousal responses during sleep, and sudden death which are all adverse physiological events related to ..
- Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neuronsEugen Brailoiu; Fiscal Year: 2009..that microinjection of G-1, a specific GPR30 agonist, or 17-estradiol (E2) into the nucleus ambiguus produces bradycardia; the effect was abolished by prior administration of G-36, a GPR30 antagonist...
- Role of nonnuclear estrogen receptor GPR30 in preganglionic vagal neuronsEugen Brailoiu; Fiscal Year: 2009..that microinjection of G-1, a specific GPR30 agonist, or 17-estradiol (E2) into the nucleus ambiguus produces bradycardia; the effect was abolished by prior administration of G-36, a GPR30 antagonist...
- Role of Ca channels in congenital heart blockMohamed Boutjdir; Fiscal Year: 2007..We have also reported for the first time significant sinus bradycardia unrelated to AV block...
- GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEARTRICHARD VEENSTRA; Fiscal Year: 2007..ventricular action potential waveforms at different rates of stimulation ranging from 240 (tachycardia) to 30 (bradycardia) beats/min...
- Air Pollution and Cardiorespiratory Events In InfantsPaige Tolbert; Fiscal Year: 2003..the first of its kind, is to examine the occurrence of cardiorespiratory events (in particular, apnea and bradycardia) in infants on home cardiorespiratory monitors in relation to daily measures of ambient air pollution in the ..