Genomes and Genes
Summary: Disorder of cardiac rhythm characterized by rapid, irregular atrial impulses and ineffective atrial contractions.
Publications265 found, 100 shown here
- [Treatment of atrial fibrillation]P Kirchhof
Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149 Munster
Internist (Berl) 48:819-29; quiz 830-1. 2007b>Atrial fibrillation is a common and in most patients recurrent arrhythmia. Atrial fibrillation can increase mortality and causes at times severe symptoms in affected patients...
- Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) StudyA S Go
Division of Research, Kaiser Permanente of Northern California, 3505 Broadway, 12th Floor, Oakland, CA 94611, USA
JAMA 285:2370-5. 2001b>Atrial fibrillation is the most common arrhythmia in elderly persons and a potent risk factor for stroke. However, recent prevalence and projected future numbers of persons with atrial fibrillation are not well described.
- Dabigatran versus warfarin in patients with atrial fibrillationStuart J Connolly
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 361:1139-51. 2009Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor.
- Effect of dronedarone on cardiovascular events in atrial fibrillationStefan H Hohnloser
Department of Cardiology, J W Goethe University, Frankfurt, Germany
N Engl J Med 360:668-78. 2009Dronedarone is a new antiarrhythmic drug that is being developed for the treatment of patients with atrial fibrillation.
- A comparison of rate control and rhythm control in patients with atrial fibrillationD G Wyse
AFFIRM Clinical Trial Center, Axio Research, 2601 4th Ave, Ste. 200, Seattle, WA 98121, USA
N Engl J Med 347:1825-33. 2002BACKGROUND: There are two approaches to the treatment of atrial fibrillation: one is cardioversion and treatment with antiarrhythmic drugs to maintain sinus rhythm, and the other is the use of rate-controlling drugs, allowing atrial ..
- Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial FibrillationB F Gage
Division of General Medical Sciences, Washington University School of Medicine Campus, Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
JAMA 285:2864-70. 2001Patients who have atrial fibrillation (AF) have an increased risk of stroke, but their absolute rate of stroke depends on age and comorbid conditions.
- New antiarrhythmic drugs for treatment of atrial fibrillationDobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Lancet 375:1212-23. 2010Inadequacies in current therapies for atrial fibrillation have made new drug development crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia...
- Rhythm or rate control in atrial fibrillation--Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trialS H Hohnloser
JW Goethe University, Frankfurt, Germany
Lancet 356:1789-94. 2000b>Atrial fibrillation is the most commonly encountered sustained cardiac arrhythmia. Restoration and maintenance of sinus rhythm is believed by many physicians to be superior to rate control only...
- Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillationRobert G Hart
Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Ann Intern Med 146:857-67. 2007b>Atrial fibrillation is a strong independent risk factor for stroke.
- Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillationGregory Y H Lip
University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
Chest 137:263-72. 2010..clinical risk stratification schemata for predicting stroke and thromboembolism (TE) in patients with atrial fibrillation (AF) are largely derived from risk factors identified from trial cohorts...
- Lifetime risk for development of atrial fibrillation: the Framingham Heart StudyDonald M Lloyd-Jones
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
Circulation 110:1042-6. 2004b>Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated.
- Apixaban in patients with atrial fibrillationStuart J Connolly
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 364:806-17. 2011Vitamin K antagonists have been shown to prevent stroke in patients with atrial fibrillation. However, many patients are not suitable candidates for or are unwilling to receive vitamin K antagonist therapy, and these patients have a high ..
- A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: the DIONYSOS studyJean Yves Le Heuzey
Cardiologie A et rythmologie, Hopital Europeen Georges Pompidou, Paris, France
J Cardiovasc Electrophysiol 21:597-605. 2010We compared the efficacy and safety of amiodarone and dronedarone in patients with persistent atrial fibrillation (AF).
- Rhythm control versus rate control for atrial fibrillation and heart failureDenis Roy
Montreal Heart Institute and the Université de Montréal, Montreal, QC H1T 1C8, Canada
N Engl J Med 358:2667-77. 2008It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation and heart failure...
- Outcomes of long-standing persistent atrial fibrillation ablation: a systematic reviewAnthony G Brooks
Department of Cardiology, Royal Adelaide Hospital and the Disciplines of Medicine and Physiology, University of Adelaide, Cardiovascular Research Centre, Adelaide, Australia
Heart Rhythm 7:835-46. 2010Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes.
- ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee foValentin Fuster
Europace 8:651-745. 2006
- Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the Strategies of Treatment of Atrial Fibrillation (STAF) studyJorg Carlsson
Department of Internal Medicine II, Klinikum Lippe Detmold, Röntgenstrasse 18, D 32760 Detmold, Germany
J Am Coll Cardiol 41:1690-6. 2003This study was designed to compare two treatment strategies in patients with atrial fibrillation(AF): rhythm-control (restoration and maintenance of sinus rhythm) and rate-control (pharmacologic or invasive rate-control and ..
- Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalenceYoko Miyasaka
Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
Circulation 114:119-25. 2006BACKGROUND: Limited data exist on trends in incidence of atrial fibrillation (AF). We assessed the community-based trends in AF incidence for 1980 to 2000 and provided prevalence projections to 2050...
- Common variants in KCNN3 are associated with lone atrial fibrillationPatrick T Ellinor
1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 4 These authors contributed equally to this work
Nat Genet 42:240-4. 2010b>Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF...
- Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trialDavid J Wilber
Cardiovascular Institute, Department of Medicine, Loyola University Medical Center, 2160 S First Ave, Bldg 110, Room 6232, Maywood, IL 60153, USA
JAMA 303:333-40. 2010Antiarrhythmic drugs are commonly used for prevention of recurrent atrial fibrillation (AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been proposed as an alternative treatment for paroxysmal AF.
- Ganglionated plexi ablation for longstanding persistent atrial fibrillationEvgeny Pokushalov
Arrhythmia Department, State Research Institute of Circulation Pathology, Novosibirsk, Russia
Europace 12:342-6. 2010To study the potential efficacy of ganglionated plexi (GP) ablation in the setting of longstanding persistent atrial fibrillation (AF).
- Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillationRiccardo Cappato
Arrhythmias and Electrophysiology Center, IRCCS, Policlinico San Donato, Milan, Italy
Circ Arrhythm Electrophysiol 3:32-8. 2010The purpose of this study was to provide an updated worldwide report on the methods, efficacy, and safety of catheter ablation of atrial fibrillation (AF).
- Worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillationRiccardo Cappato
Arrhythmia and Electrophysiology Center, Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
Circulation 111:1100-5. 2005The purpose of this study was to conduct a worldwide survey investigating the methods, efficacy, and safety of catheter ablation (CA) of atrial fibrillation (AF).
- Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trialS Connolly
Health Research Institute, Hamilton, ON, Canada
Lancet 367:1903-12. 2006Oral anticoagulation therapy reduces risk of vascular events in patients with atrial fibrillation. However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation...
- Bisphosphonates and atrial fibrillation: systematic review and meta-analysisYoon Kong Loke
School of Medicine, University of East Anglia, Norwich, UK
Drug Saf 32:219-28. 2009Bisphosphonates are widely used in osteoporosis, but there have been concerns about a potential link between bisphosphonate therapy and atrial fibrillation.
- HRS/EHRA/ECAS expert Consensus Statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) Task Force on catheter and surgical ablation of Hugh Calkins
Johns Hopkins Hospital, Maryland, USA
Heart Rhythm 4:816-61. 2007
- Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart StudyThomas J Wang
Framingham Heart Study, 73 Mt Wayte Ave, Suite #2, Framingham, Mass 01702-5827, USA
Circulation 107:2920-5. 2003BACKGROUND: Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality...
- Increasing prevalence of atrial fibrillation and flutter in the United StatesGerald V Naccarelli
Pennsylvania State Heart and Vascular Institute, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania, USA
Am J Cardiol 104:1534-9. 2009The prevalence data for atrial fibrillation (AF) are dated. The present retrospective study estimated the current and projected prevalence of AF and atrial flutter (AFL) in the United States using a large national database...
- Feasibility and safety of remote-controlled magnetic navigation for ablation of atrial fibrillationWilliam T Katsiyiannis
Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA
Am J Cardiol 102:1674-6. 2008Radiofrequency ablation for atrial fibrillation (AF) involves complex catheter manipulation resulting in prolonged procedure time and fluoroscopy exposure...
- Bisphosphonate use in women and the risk of atrial fibrillation: a systematic review and meta-analysisRohit Bhuriya
Division of Cardiology, Department of Medicine, The Chicago Medical School, North Chicago, Illinois 60064, United States
Int J Cardiol 142:213-7. 2010..of osteoporosis, but there have been concerns about a potential link between bisphosphonate therapy and atrial fibrillation. Data on the effects of bisphosphonate on the risk of atrial fibrillation are conflicting and the ..
- Long-term outcome after successful catheter ablation of atrial fibrillationWendy S Tzou
Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Circ Arrhythm Electrophysiol 3:237-42. 2010Pulmonary vein isolation (PVI) is increasingly used for treatment of atrial fibrillation (AF), but few reports exist regarding long-term success...
- Atrial fibrillation after isolated coronary surgery affects late survivalGiovanni Mariscalco
Department of Surgical Sciences, Cardiac Surgery Division, Varese University Hospital, I 21100 Varese, Italy
Circulation 118:1612-8. 2008b>Atrial fibrillation (AF) after coronary artery bypass graft surgery is a difficult problem and a continuing source of morbidity and mortality. However, the prognostic implications of postoperative AF are still in dispute...
- Left atrial linear lesions are required for successful treatment of persistent atrial fibrillationSebastien Knecht
Service de Rythmologie, Hopital Cardiologique du Haut Leveque, CHU de Bordeaux Université Victor Segalen Bordeaux II, Bordeaux Pessac, France
Eur Heart J 29:2359-66. 2008..the clinical outcome and incidence of left atrial (LA) macro re-entrant atrial tachycardia (AT) in patients in whom persistent atrial fibrillation (AF) terminated during catheter ablation without the need of roof and mitral lines.
- Independent susceptibility markers for atrial fibrillation on chromosome 4q25Steven A Lubitz
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02114, USA
Circulation 122:976-84. 2010Genetic variants on chromosome 4q25 are associated with atrial fibrillation (AF). We sought to determine whether there is more than 1 susceptibility signal at this locus.
- Catheter ablation of long-standing persistent atrial fibrillation: a lesson from circumferential pulmonary vein isolationRoland Richard Tilz
II Medizinische Abteilung, Asklepios Klinik St Georg, Hamburg, Germany
J Cardiovasc Electrophysiol 21:1085-93. 2010..vein isolation (CPVI) is associated with a high success rate in patients with paroxysmal and persistent atrial fibrillation (AF)...
- A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart SurveyRon Pisters
Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
Chest 138:1093-100. 2010Despite extensive use of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and the increased bleeding risk associated with such OAC use, no handy quantification tool for assessing this risk exists...
- Rate control vs rhythm control in patients with nonvalvular persistent atrial fibrillation: the results of the Polish How to Treat Chronic Atrial Fibrillation (HOT CAFE) StudyGrzegorz Opolski
Department of Cardiology, Medical University of Warsaw, Warsaw, Poland
Chest 126:476-86. 2004The relative risks and benefits of strategies of rate control vs rhythm control in patients with atrial fibrillation (AF) remain to be fully explored.
- Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationaleRenato D Lopes
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
Am Heart J 159:331-9. 2010b>Atrial fibrillation (AF) is associated with increased risk of stroke that can be attenuated with vitamin K antagonists (VKAs)...
- Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillationMorten L Hansen
Department of Cardiology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65 2900, Hellerup, Copenhagen, Denmark
Arch Intern Med 170:1433-41. 2010Patients with atrial fibrillation (AF) often require anticoagulation and platelet inhibition, but data are limited on the bleeding risk of combination therapy.
- Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillationHiroshi Watanabe
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
Circ Arrhythm Electrophysiol 2:268-75. 2009We and others have reported mutations in the cardiac predominant sodium channel gene SCN5A in patients with atrial fibrillation (AF)...
- Cost of an emerging epidemic: an economic analysis of atrial fibrillation in the UKS Stewart
Division of Health Sciences, The University of South Australia, Adelaide, Australia
Heart 90:286-92. 2004OBJECTIVE: To evaluate the cost of atrial fibrillation (AF) to health and social services in the UK in 1995 and, based on epidemiological trends, to project this estimate to 2000...
- A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrateKoonlawee Nademanee
Pacific Rim Electrophysiology Research Institute, Inglewood, California 90301, USA
J Am Coll Cardiol 43:2044-53. 2004We sought to test the hypothesis that complex fractionated electrograms (CFAEs) recorded during atrial fibrillation (AF) could be used as target sites for catheter ablation of AF.
- Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillationBianca J J M Brundel
Department of Radiation and Stress Cell Biology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
J Mol Cell Cardiol 41:555-62. 2006b>Atrial fibrillation (AF) causes myocyte stress by inducing structural changes, predominantly myolysis, which is related to the progression of AF...
- Antithrombotic treatment in atrial fibrillationL Kalra
Cardiovascular Division, King's College London School of Medicine, London, UK
Heart 93:39-44. 2007
- Lenient versus strict rate control in patients with atrial fibrillationIsabelle C Van Gelder
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
N Engl J Med 362:1363-73. 2010Rate control is often the therapy of choice for atrial fibrillation. Guidelines recommend strict rate control, but this is not based on clinical evidence...
- A multicenter risk index for atrial fibrillation after cardiac surgeryJoseph P Mathew
Multicenter Study of Perioperative Ischemia Research Group and Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
JAMA 291:1720-9. 2004b>Atrial fibrillation is a common, but potentially preventable, complication following coronary artery bypass graft (CABG) surgery.
- Alternative endpoints for mortality in studies of patients with atrial fibrillation: the AFFIRM study experienceD George Wyse
Libin Cardiovascular Institute of Alberta, University of Calgary, Canada
Heart Rhythm 1:531-7. 2004..particularly hospitalization for cardiovascular reasons (CV hospitalization), as an endpoint in studies of atrial fibrillation (AF) using the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) database...
- Decrease in the heart rate complexity prior to the onset of atrial fibrillationVolkan Tuzcu
Department of Pediatrics, Division of Cardiology, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, 800 Marshall Street, Slot 512 3, Little Rock, AR 72202, USA
Europace 8:398-402. 2006To assess heart rate complexity changes prior to the onset of atrial fibrillation (AF) using sample entropy. It has been proposed that the autonomic nervous system might have a role in the initiation of AF.
- Postoperative atrial fibrillation and mortality after coronary artery bypass surgeryRollo P Villareal
Section of Cardiology, Self Regional Healthcare, Greenwood, South Carolina 29646, USA
J Am Coll Cardiol 43:742-8. 2004We sought to determine if the occurrence of postoperative atrial fibrillation (AF) affects early or late mortality following coronary artery bypass surgery (CABG).
- Video-assisted bilateral pulmonary vein isolation and left atrial appendage exclusion for atrial fibrillationRandall K Wolf
Section of Cardiothoracic Surgery, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Thorac Cardiovasc Surg 130:797-802. 2005Pulmonary vein isolation is curative in selected patients with atrial fibrillation. The objective of this study was to assess the feasibility and safety (midterm results) of video-assisted thoracoscopic epicardial pulmonary vein isolation.
- Localized sources maintaining atrial fibrillation organized by prior ablationMichel Haissaguerre
Hopital Cardiologique du Haut Leveque, University Victor Segalen, Bordeaux, France
Circulation 113:616-25. 2006Endocardial mapping of localized sources driving atrial fibrillation (AF) in humans has not been reported.
- A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillationIsabelle C Van Gelder
Department of Cardiology, Thoraxcenter, University Hospital, Groningen, The Netherlands
N Engl J Med 347:1834-40. 2002Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm...
- Population prevalence, incidence, and predictors of atrial fibrillation in the Renfrew/Paisley studyS Stewart
Clinical Research Initiative in Heart Failure, Wolfson Building (Level 3, University of Glasgow, Glasgow G12 8QQ, UK
Heart 86:516-21. 2001OBJECTIVES: Though atrial fibrillation (AF) is an important cause of cardiovascular morbidity, there are few large epidemiological studies of its prevalence, incidence, and risk factors...
- Analysis of stroke in ATHENA: a placebo-controlled, double-blind, parallel-arm trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fibrillation/atrial Stuart J Connolly
FRCPC, Division of Cardiology, Hamilton Health Sciences, General Site, 502 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada
Circulation 120:1174-80. 2009Many patients with atrial fibrillation are at high risk for stroke and require antithrombotic therapy. Antiarrhythmic drugs have not previously been shown to reduce the risk of stroke in atrial fibrillation...
- A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic strokeDaniel F Gudbjartsson
deCODE Genetics, Reykjavik, Iceland
Nat Genet 41:876-8. 2009We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States...
- Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillationChristoph Rocken
Department of Pathology, Otto von Guericke University, Magdeburg, Germany
Circulation 106:2091-7. 2002Structural changes, like atrial fibrosis, may increase the likelihood of atrial fibrillation (AF) occurring in response to triggering events. The influence of isolated atrial amyloidosis (IAA) is largely unknown.
- Aortic plaque in atrial fibrillation: prevalence, predictors, and thromboembolic implicationsJ L Blackshear
Mayo Clinic Jacksonville, Jacksonville, Fla 32224, USA
Stroke 30:834-40. 1999..aortic plaque identified by transesophageal echocardiography heightens the risk of stroke associated with atrial fibrillation (AF)...
- A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley studySimon Stewart
Division of Health Sciences at the University of South Australia, Adelaide, Australia
Am J Med 113:359-64. 2002PURPOSE: To describe the effect of atrial fibrillation on long-term morbidity and mortality. SUBJECTS AND METHODS: The Renfrew/Paisley Study surveyed 7052 men and 8354 women aged 45-64 years between 1972 and 1976...
- Impact of atrial fibrillation on the risk of death: the Framingham Heart StudyE J Benjamin
National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Mass, USA
Circulation 98:946-52. 1998b>Atrial fibrillation (AF) causes substantial morbidity. It is uncertain whether AF is associated with excess mortality independent of associated cardiac conditions and risk factors.
- Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy: 5-year results of the PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) StudyPeter C Block
Emory University, Atlanta, GA 30322, USA
JACC Cardiovasc Interv 2:594-600. 2009..The aim of this study was to determine 5-year clinical status for patients treated with percutaneous left atrial appendage transcatheter occlusion with the PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) system...
- Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trialDavid R Holmes
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Lancet 374:534-42. 2009In patients with non-valvular atrial fibrillation, embolic stroke is thought to be associated with left atrial appendage (LAA) thrombi...
- Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: two systematic literature reviews and meta-analysesHugh Calkins
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Circ Arrhythm Electrophysiol 2:349-61. 2009..catheter ablation (RFA) has evolved from an experimental procedure to an important treatment option for atrial fibrillation, the relative safety and efficacy of catheter ablation relative to that of antiarrhythmic drug (AAD) ..
- Atrial fibrillation after cardiac surgeryW H Maisel
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Ann Intern Med 135:1061-73. 2001To review the epidemiology, mechanisms, complications, predictors, prevention, and treatment of atrial fibrillation following cardiac surgery.
- [Atrial fibrillation, atrial flutter]Takayuki Otsuka
The Cardiovascular Institute
Nippon Rinsho . 2007
- [Atrial fibrillation -- interventional therapy with respect to age]Th Lewalter
Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn
Dtsch Med Wochenschr 130:721-5. 2005Actual therapy of atrial fibrillation follows either the rate or rhythm control strategy. To stabilize sinus rhythm after cardioversion or in case of paroxysmal atrial fibrillation, medical treatment is currently first line therapy...
- The effect of atrial pacing therapies on atrial tachyarrhythmia burden and frequency: results of a randomized trial in patients with bradycardia and atrial tachyarrhythmiasMichael A Lee
John Muir Mount Diablo Medical Center, Walnut Creek, California, USA
J Am Coll Cardiol 41:1926-32. 2003The Atrial Therapy Efficacy and Safety Trial (ATTEST) was a prospective, randomized study to evaluate preventive pacing and antitachycardia pacing (ATP) in patients with symptomatic atrial fibrillation (AF) or atrial tachycardia (AT).
- Electrophysiological findings in adolescents with atrial fibrillation who have structurally normal heartsKumaraswamy Nanthakumar
Division of Cardiovascular Diseases, University of Alabama at Birmingham, 1670 University Blvd, B140 Volker Hall, Birmingham AL 35294 0019, USA
Circulation 110:117-23. 2004b>Atrial fibrillation (AF) is uncommon in children, and its mechanisms are unknown. This study describes the electrophysiological findings in children and adolescents with AF and the outcome of catheter ablation.
- Outcome parameters for trials in atrial fibrillation: executive summaryPaulus Kirchhof
Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
Eur Heart J 28:2803-17. 2007b>Atrial fibrillation (AF), the most common atrial arrhythmia, has a complex aetiology and causes relevant morbidity and mortality due to different mechanisms, including but not limited to stroke, heart failure, and tachy- or ..
- Recovered pulmonary vein conduction as a dominant factor for recurrent atrial tachyarrhythmias after complete circular isolation of the pulmonary veins: lessons from double Lasso techniqueFeifan Ouyang
II Medizinische Abteilung, Allgemeines Krankenhaus St Georg, Lohmuhlenstrasse 5, 20099 Hamburg, Germany
Circulation 111:127-35. 2005..after continuous circular lesions (CCLs) around the ipsilateral pulmonary veins (PVs) in patients with atrial fibrillation (AF)...
- Left atrial pacemaker dominance after catheter ablation of atrial fibrillationPrashanthan Sanders
Hôpital Cardologique du Haut Lévêque and the Université Victor Segalen Bordeaux 2, Bordeaux, France
J Cardiovasc Electrophysiol 15:1324-7. 2004We report a case of left atrial dominant rhythm demonstrated by electroanatomic mapping. The rhythm occurred after radiofrequency catheter ablation in a patient with persistent atrial fibrillation and structural heart disease.
- Circumferential pulmonary vein isolation: the role of key target sitesXin Hua Wang
Department of Cardiology, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200030, PR China
Europace 10:197-204. 2008Circumferential pulmonary vein isolation (CPVI) had been proved effective for treating atrial fibrillation (AF). However, the achievement of pulmonary vein (PV) isolation was sometimes challenging...
- Noninducibility of atrial fibrillation as an end point of left atrial circumferential ablation for paroxysmal atrial fibrillation: a randomized studyHakan Oral
Division of Cardiology, University of Michigan, Ann Arbor, USA
Circulation 110:2797-801. 2004..ablation (LACA) to encircle the pulmonary veins is often effective in eliminating paroxysmal atrial fibrillation (AF)...
- [Atrial fibrillation: the most common arrhythmia]Jean Yves Le Heuzey
Service de cardiologie A, Hopital Europeen Georges Pompidou, F 75015 Paris, France
Presse Med 37:821-6. 2008The incidence of atrial fibrillation increases rapidly with population age. Atrial fibrillation essentially presents a problem of long-term management...
- Complete isolation of left atrium surrounding the pulmonary veins: new insights from the double-Lasso technique in paroxysmal atrial fibrillationFeifan Ouyang
II Medizinische Abteilung, Allgemeines Krankenhaus St Georg, Hamburg, Germany
Circulation 110:2090-6. 2004Paroxysmal atrial fibrillation (PAF) can be eliminated with continuous circular lesions (CCLs) around the pulmonary veins (PVs), but it is unclear whether all PVs are completely isolated.
- Circumferential pulmonary vein ablation for treatment of atrial fibrillation using an irrigated-tip catheterMarc Horlitz
HELIOS Klinikum Wuppertal, Heartcenter Wuppertal, University of Witten Herdecke, Cardiology, Department of Electrophysiology, Wuppertal, Germany
Am J Cardiol 94:945-7. 2004In this study, a series of 52 consecutive patients with atrial fibrillation from 1 institution underwent circumferential pulmonary vein ablation using an irrigated-tip catheter...
- Mechanisms of organized left atrial tachycardias occurring after pulmonary vein isolationEdward P Gerstenfeld
Hospital of the University of Pennsylvania, 9 Founders Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA
Circulation 110:1351-7. 2004..This arrhythmia is frequently referred to as "left atrial flutter," but the mechanism and best ablation strategy have not been determined...
- A prospective multicenter trial of bipolar radiofrequency ablation for atrial fibrillation: early resultsNahush A Mokadam
Division of Cardiothoracic Surgery, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Ann Thorac Surg 78:1665-70. 2004BACKGROUND: The Cox-Maze III remains the gold standard for the surgical treatment of atrial fibrillation. However, the "cut-and-sew" technique is time consuming and technically challenging...
- Biatrial and three-dimensional mapping of spontaneous atrial arrhythmias in patients with refractory atrial fibrillationSanjeev Saksena
Electrophysiology Research Foundation, Warren, New Jersey, USA
J Cardiovasc Electrophysiol 16:494-504. 2005INTRODUCTION: While atrial fibrillation (AF) initiation in the pulmonary veins has been well-studied, simultaneous biatrial and three-dimensional noncontact mapping (NCM) has not been performed...
- Pulmonary vein antrum isolationMohamed Kanj
The Cleveland Clinic, Cleveland, Ohio 44195, USA
Heart Rhythm 4:S73-9. 2007Pulmonary vein antrum isolation offers safe and effective treatment of atrial fibrillation by eliminating the potential triggers of this arrhythmia...
- Combined atrial fibrillation ablation with mitral valve surgeryThierry G Mesana
Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
J Heart Valve Dis 15:515-20. 2006The study aim was to evaluate the efficacy and outcome of radiofrequency (RF) atrial fibrillation (AF) ablation in patients undergoing mitral valve (MV) surgery.
- [Cardiac arrhythmias in the elderly]Louis Guize
, 20 rue Leblanc, 75015 Paris
Bull Acad Natl Med 190:827-41; discussion 873-6. 2006..b>Atrial fibrillation, the prevalence of which exceeds 10% after 80 years, is usually related to hypertensive or ischemic heart ..
- [Atrial fibrillation: current therapeutic options]Berndt Luderitz
Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn
Med Klin (Munich) 101:147-9. 2006The treatment of atrial fibrillation still remains challenging in everyday practice. Even after the introduction of catheter ablation, the decision making about the type of therapy became more complex...
- Circumferential ablation with pulmonary vein isolation in permanent atrial fibrillationAamir Cheema
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 99:1425-8. 2007Each of the main approaches to catheter ablation of atrial fibrillation (AF, segmental and circumferential) is associated with limited efficacy in patients with permanent AF...
- Radiofrequency ablation of drug-refractory atrial fibrillation: an observational study comparing 'ablate and pace' with pulmonary vein isolationAlessandro Proclemer
Department of Cardiology, Azienda Ospedaliera Universitaria and IRCAB Foundation, P le S Maria della Misericordia 15, 33100 Udine, Italy
Europace 10:1085-90. 2008..complexity, acute and long-term outcome of 'ablate and pace' (A&P) with pulmonary vein isolation (PVI) in patients with drug-refractory atrial fibrillation (AF). So far, only few small studies have compared the two procedures.
- Sites of focal atrial activity characterized by endocardial mapping during atrial fibrillationYoshihide Takahashi
Hôpital Cardiologique du Haut Lévêque Université Victor Segalen Bordeaux 2, Bordeaux, France
J Am Coll Cardiol 47:2005-12. 2006The aim of the present study was to assess the feasibility of identifying sites of focal atrial activity by localized high-density endocardial mapping during atrial fibrillation (AF).
- A novel finding--isolated Marshall's ligament rhythm after catheter ablation and reconnection of the Marshall's ligament with the left atrium after an adenosine bolus in one patient with atrial fibrillationTa-Chuan Tuan
Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taoyuan Veteran Hospital, Taiwan
J Cardiovasc Electrophysiol 18:1220-1. 2007
- Impact of follow-up on the success rate of the cryosurgical maze procedure in patients with rheumatic heart disease and enlarged atriaNiv Ad
Division of Cardiac Surgery, The Inova Heart and Vascular Institute, Falls Church, VA 22042, USA
J Thorac Cardiovasc Surg 131:1073-9. 2006The most important predictors for failure of the maze procedure are long standing atrial fibrillation (AF), rheumatic heart disease (RHD), and enlarged atria...
- MR evaluation of pulmonary vein diameter reduction after radiofrequency catheter ablation of atrial fibrillationFrederic Anselme
Department of Cardiology, Rouen University Hospital, Rouen, France
Eur Radiol 16:2505-11. 2006Fifty consecutive patients aged 52+/-12 years suffering from drug refractory atrial fibrillation (AF) underwent baseline and post-ablation MR angiography (MRA) at a mean follow-up of 4+/-3.5 months...
- [Atrial remodeling and anti-remodeling therapy in atrial fibrillation]T Neumann
Medizinische Klinik I, Kardiologie und Angiologie,
Dtsch Med Wochenschr 131:884-7. 2006
- Left atrial size reduction improves the sinus rhythm conversion rate after radiofrequency ablation for continuous atrial fibrillation in patients undergoing concomitant cardiac surgeryM Scherer
Department of Thoracic and Cardiovascular Surgery, J W Goethe University, Frankfurt Main, Germany
Thorac Cardiovasc Surg 54:34-8. 2006..Radiofrequency (RF) ablation can effectively restore sinus rhythm in the majority of patients with continuous atrial fibrillation (AF)...
- [Atrial flutter and fibrillation]C Scharf
HerzGefässZentrum, Klinik Im Park, Zurich
Praxis (Bern 1994) 94:1753-9. 2005..In contrast atrial fibrillation, especially when occurring paroxysmal at the beginning, is arising from triggers within the pulmonary veins...
- Hybrid therapy with pilsicainide and pulmonary vein isolation for atrial fibrillationHideaki Tojo
Department of Cardiology, Fukuoka University Hospital, Japan
Circ J 69:1503-7. 2005BACKGROUND: Pulmonary vein (PV) isolation is commonly performed in patients with drug-refractory atrial fibrillation (AF) and in cases of unsuccessful ablation, antiarrhythmic agents that were ineffective before the ablation sometimes ..
- Long-term efficacy of hybrid pharmacologic and ablation therapy in patients with pilsicainide-induced atrial flutterKenzo Hirao
Department of Cardiovascular Medicine, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Clin Cardiol 28:338-42. 2005..cavo-tricuspid isthmus and continued drug therapy, that is, "hybrid therapy," in patients with atrial fibrillation (AF) and drug-induced atrial flutter (AFL) is reported to be an alternative means of achieving and ..
- A novel method of multisite atrial pacing, incorporating Bachmann's bundle area and coronary sinus ostium, for electrical atrial resynchronization in patients with recurrent atrial fibrillationEwa Lewicka-Nowak
Department of Cardiology and Electrotherapy, Medical University of Gdansk, ul Debinki 7, 80 211, Gdansk, Poland
Europace 9:805-11. 2007..of a novel method of multisite atrial pacing, incorporating Bachmann's bundle (BB) and coronary sinus (CS) ostium pacing, which was implemented for the first time in atrial fibrillation (AF) patients with intra-atrial conduction delay.
- Mapping and ablation of left atrial tachycardias occurring after atrial fibrillation ablationEdward P Gerstenfeld
Division of Cardiology, Department of Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
Heart Rhythm 4:S65-72. 2007Regular left atrial tachycardias are a frequent complication of atrial fibrillation ablation procedures...
- Curative surgery for atrial fibrillation. Current status and minimally invasive approachesJ L Navia
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Minerva Cardioangiol 52:155-68. 2004b>Atrial fibrillation (AF) is the most common disorder of heart rhythm. Affecting 2.2 million Americans and millions more worldwide, AF is a dangerous and costly epidemic...
- Utility of exit block for identifying electrical isolation of the pulmonary veinsEdward P Gerstenfeld
University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Cardiovasc Electrophysiol 13:971-9. 2002Electrical isolation of the pulmonary veins (PVs) to treat paroxysmal atrial fibrillation (AF) has been described using "entry block" as an endpoint for PV isolation...
- Relation between pulmonary vein firing and extent of left atrial-pulmonary vein connection in patients with atrial fibrillationHiroshi Nakagawa
Cardiac Arrhythmia Research Institute and the Department of Medicine, University of Oklahoma Health Sciences Center, 1200 Everett Drive TUH 6E 103, Oklahoma City, Okla 73104, USA
Circulation 109:1523-9. 2004The purpose of this study was to measure the extent of left atrial-pulmonary vein (LA-PV) connections and determine the relation to PV firing in patients with atrial fibrillation (AF).
- Efficacy and safety of targeted focal ablation versus PV isolation assisted by magnetic electroanatomic mappingFrancis E Marchlinski
Electrophysiology Section, Division of Cardiology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
J Cardiovasc Electrophysiol 14:358-65. 2003Pulmonary vein (PV) triggers initiate atrial fibrillation (AF)...
- Echocardiographic and electrocardiographic predictors for atrial fibrillation recurrence following cardioversionAndreas Bollmann
Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
J Cardiovasc Electrophysiol 14:S162-5. 2003..fibrillatory rate obtained from the surface ECG (as a measure of electrical remodeling) and left atrial size (as measure of mechanical remodeling) for prediction of early atrial fibrillation (AF) recurrence following cardioversion.
- Evidence for longitudinal and transverse fiber conduction in human pulmonary veins: relevance for catheter ablationJavier E Sanchez
University of Alabama at Birmingham, 321G Tinsley Harrison Tower, Birmingham, Ala, USA
Circulation 108:590-7. 2003Segmental ostial ablation of the pulmonary veins (PVs) allows for successful control of paroxysmal atrial fibrillation in many patients...
- A randomized trial of interventions to improve warfarin adherenceKevin G Volpp; Fiscal Year: 2010Warfarin is used by millions of Americans with conditions such as atrial fibrillation and deep venous thrombosis to lower their risk of thromboembolic events (e.g., stroke or pulmonary embolism)...
- Improved Targeting and Assessment of Electrophysiology InterventionHenry Halperin; Fiscal Year: 2009b>Atrial fibrillation (AF) and ventricular tachycardia (VT) affect millions of patients in the United States. These arrhythmias can be cured with catheter ablation, but the arrhythmias often recur...
- Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common CardiacQing Kenneth Wang; Fiscal Year: 2010b>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with more than 2 million Americans affected, and is growing exponentially...
- Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteinsRishi Arora; Fiscal Year: 2009b>Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
- Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteinsRishi Arora; Fiscal Year: 2009b>Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
- Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteinsRishi Arora; Fiscal Year: 2010b>Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
- Pharmacogenetics and Cardiovascular EventsBruce Psaty; Fiscal Year: 2006..to assess drug-gene interactions on the outcomes of myocardial infarction (MI), stroke, and new-onset atrial fibrillation (AF). The 3 case groups share a single population-based control group...
- Improved Targeting and Assessment of Electrophysiology InterventionHenry R Halperin; Fiscal Year: 2010b>Atrial fibrillation (AF) and ventricular tachycardia (VT) affect millions of patients in the United States. These arrhythmias can be cured with catheter ablation, but the arrhythmias often recur...
- ELECTRODE DESIGN FOR CARDIAC TACHYARRYTHMIA RF ABLATIONJohn Webster; Fiscal Year: 2002..Adapted from Applicant's Abstract): The goal of this study is to optimize catheter design for the cure of atrial fibrillation and ventricular tachycardia by endocardial radiofrequency (RF) ablation...
- A randomized trial of interventions to improve warfarin adherenceStephen Kimmel; Fiscal Year: 2009Warfarin is used by millions of Americans with conditions such as atrial fibrillation and deep venous thrombosis to lower their risk of thromboembolic events (e.g., stroke or pulmonary embolism)...
- RAAS, Inflammation & Post-Operative Atrial FibrillationNancy Brown; Fiscal Year: 2009b>Atrial fibrillation is the most prevalent sustained cardiac arrhythmia, affecting over 2 million Americans...
- A multiethnic comparative effectiveness study for diagnosis of cardiogenic strokeJeffrey R Gulcher; Fiscal Year: 2010..b>Atrial fibrillation (AF) is known to be a major cause of stroke involved in at least 20% of all ischemic strokes (cardiogenic ..
- Mechanical stretch and fibrillation dynamics in the left atriumJerome Kalifa; Fiscal Year: 2007b>Atrial fibrillation (AF) is the most common arrhythmia in adults and is associated with atrial dilatation which may be acute or chronic...
- Development of Novel Approaches for the Pharmacologic Treatment of Atrial FibrillCharles Antzelevitch; Fiscal Year: 2011..assess how these distinctions contribute to atrial-selective sodium channel inhibition and suppression of atrial fibrillation by INa blockers;2) determine to what extent the electrical and pharmacologic heterogeneities uncovered in ..
- Real-time MRI-guided RF Ablation of Cardiac TachyArrhythmiasOrhan Unal; Fiscal Year: 2009b>Atrial fibrillation (AF) is the most common adult cardiac tachyarrhythmia affecting more than 2,200,000 people in the US. AF also accounts for 15% of all strokes...
- VERY LOW ENERGY CARDIOVERSION FOR ATRIAL FIBRILLATIONPatrick Wolf; Fiscal Year: 2003Internal atrial defibrillation is a successful therapy for the treatment of atrial fibrillation(AF)...
- CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial FibrillationXANDER WEHRENS; Fiscal Year: 2009..ventricular tachycardia (CPVT), but may also provide an arrhythmogenic trigger in acquired arrhythmias like atrial fibrillation (AF)...
- CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial FibrillationXander H T Wehrens; Fiscal Year: 2010..ventricular tachycardia (CPVT), but may also provide an arrhythmogenic trigger in acquired arrhythmias like atrial fibrillation (AF)...
- CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial FibrillationXANDER WEHRENS; Fiscal Year: 2007..ventricular tachycardia (CPVT), but may also provide an arrhythmogenic trigger in acquired arrhythmias like atrial fibrillation (AF)...
- CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial FibrillationXANDER WEHRENS; Fiscal Year: 2009
- CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial FibrillationXander H T Wehrens; Fiscal Year: 2010
- Determining the Role of the Potassium Channel, KCNN3, in Atrial FibrillationPATRICK THOMAS ELLINOR; Fiscal Year: 2010b>Atrial fibrillation (AF) is the most common arrhythmia and affects over 2 million Americans...
- Risks of Warfarin for Elders with Atrial FibrillationMargaret Fang; Fiscal Year: 2007..Dr. Fang's overall career goal is to optimize stroke prevention in older patients with atrial fibrillation. She will develop a research program that will explore clinical and biological risk factors for stroke and ..
- Virtual Electrical-Anatomical Imaging of the HeartDirar Khoury; Fiscal Year: 2005DESCRIPTION: (Provided by Applicant): Atrial fibrillation (AF) is the most common heart rhythm disorder: it affects more than two million Americans, is responsible for one-third of all strokes over the age of 65 years, and annually ..
- Homogeneous Transfer of Connexin 43 to Prevent Atrial Fibrillation in PigsHao Qin; Fiscal Year: 2007As the most common arrhythmia affecting ~2 million Americans, chronic atrial fibrillation (AF) is associated with numerous pathological sequelae such as stroke and tachycardia related cardiomyopathy...