atrial fibrillation

Summary

Summary: Disorder of cardiac rhythm characterized by rapid, irregular atrial impulses and ineffective atrial contractions.

Top Publications

  1. ncbi Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
  2. ncbi Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    Manesh R Patel
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 365:883-91. 2011
  3. ncbi Apixaban versus warfarin in patients with atrial fibrillation
    Christopher B Granger
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    N Engl J Med 365:981-92. 2011
  4. ncbi Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
    A S Go
    Division of Research, Kaiser Permanente of Northern California, 3505 Broadway, 12th Floor, Oakland, CA 94611, USA
    JAMA 285:2370-5. 2001
  5. ncbi Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)
    A John Camm
    Eur Heart J 31:2369-429. 2010
  6. ncbi Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation
    B F Gage
    Division of General Medical Sciences, Washington University School of Medicine Campus, Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    JAMA 285:2864-70. 2001
  7. ncbi Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    Chest 137:263-72. 2010
  8. ncbi A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey
    Ron Pisters
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Chest 138:1093-100. 2010
  9. ncbi Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 146:857-67. 2007
  10. ncbi ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice
    Valentin Fuster
    Circulation 114:e257-354. 2006

Detail Information

Publications355 found, 100 shown here

  1. ncbi Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor.
  2. ncbi Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    Manesh R Patel
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 365:883-91. 2011
    The use of warfarin reduces the rate of ischemic stroke in patients with atrial fibrillation but requires frequent monitoring and dose adjustment...
  3. ncbi Apixaban versus warfarin in patients with atrial fibrillation
    Christopher B Granger
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    N Engl J Med 365:981-92. 2011
    Vitamin K antagonists are highly effective in preventing stroke in patients with atrial fibrillation but have several limitations...
  4. ncbi Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
    A S Go
    Division of Research, Kaiser Permanente of Northern California, 3505 Broadway, 12th Floor, Oakland, CA 94611, USA
    JAMA 285:2370-5. 2001
    b>Atrial fibrillation is the most common arrhythmia in elderly persons and a potent risk factor for stroke. However, recent prevalence and projected future numbers of persons with atrial fibrillation are not well described.
  5. ncbi Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)
    A John Camm
    Eur Heart J 31:2369-429. 2010
  6. ncbi Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation
    B F Gage
    Division of General Medical Sciences, Washington University School of Medicine Campus, Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    JAMA 285:2864-70. 2001
    Patients who have atrial fibrillation (AF) have an increased risk of stroke, but their absolute rate of stroke depends on age and comorbid conditions.
  7. ncbi Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    Chest 137:263-72. 2010
    ..clinical risk stratification schemata for predicting stroke and thromboembolism (TE) in patients with atrial fibrillation (AF) are largely derived from risk factors identified from trial cohorts...
  8. ncbi A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey
    Ron Pisters
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Chest 138:1093-100. 2010
    Despite extensive use of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and the increased bleeding risk associated with such OAC use, no handy quantification tool for assessing this risk exists...
  9. ncbi Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 146:857-67. 2007
    b>Atrial fibrillation is a strong independent risk factor for stroke.
  10. ncbi ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice
    Valentin Fuster
    Circulation 114:e257-354. 2006
  11. ncbi Edoxaban versus warfarin in patients with atrial fibrillation
    Robert P Giugliano
    From Brigham and Women s Hospital and Harvard Medical School, Boston R P G, C T R, E B, S A M, S D W, L T G, E M A Mount Sinai Medical Center, New York J L H University Hospitals Case Medical Center, Cleveland A L W Thomas Jefferson Medical College, Philadelphia M D E McMaster University, Hamilton, ON, Canada J I W University Hospital, Jihlavská, Brno, Czech Republic J S Institute of Cardiology, Warsaw, Poland W R Cardiology Research Center, Moscow M R National Hospital Organization, Osaka National Hospital, Osaka, Japan Y K Quintiles, Durham, NC J B, S P P and Daiichi Sankyo Pharma Development, Edison, NJ M S, I P, J J H, M M
    N Engl J Med 369:2093-104. 2013
    Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known.
  12. ncbi Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    Vitamin K antagonists have been shown to prevent stroke in patients with atrial fibrillation. However, many patients are not suitable candidates for or are unwilling to receive vitamin K antagonist therapy, and these patients have a high ..
  13. pmc The net clinical benefit of warfarin anticoagulation in atrial fibrillation
    Daniel E Singer
    Massachusetts General Hospital, Boston, Massachussetts 02114, USA
    Ann Intern Med 151:297-305. 2009
    Guidelines recommend warfarin use in patients with atrial fibrillation solely on the basis of risk for ischemic stroke without antithrombotic therapy...
  14. ncbi Underuse of oral anticoagulants in atrial fibrillation: a systematic review
    Isla M Ogilvie
    BioMedCom Consultants Inc, Montreal, QC, Canada
    Am J Med 123:638-645.e4. 2010
    b>Atrial fibrillation is associated with substantial mortality and morbidity from stroke and thromboembolism...
  15. ncbi Subclinical atrial fibrillation and the risk of stroke
    Jeff S Healey
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 366:120-9. 2012
    One quarter of strokes are of unknown cause, and subclinical atrial fibrillation may be a common etiologic factor...
  16. ncbi Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence
    Yoko Miyasaka
    Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Circulation 114:119-25. 2006
    Limited data exist on trends in incidence of atrial fibrillation (AF). We assessed the community-based trends in AF incidence for 1980 to 2000 and provided prevalence projections to 2050.
  17. ncbi Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study
    Jan Heeringa
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Heart J 27:949-53. 2006
    We aimed to investigate the prevalence and incidence of atrial fibrillation (AF) in a large European population-based study.
  18. pmc Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    John J You
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 141:e531S-75S. 2012
    The risk of stroke varies considerably across different groups of patients with atrial fibrillation (AF). Antithrombotic prophylaxis for stroke is associated with an increased risk of bleeding...
  19. ncbi n-3 polyunsaturated fatty acids in the prevention of atrial fibrillation recurrences after electrical cardioversion: a prospective, randomized study
    Savina Nodari
    Department of Experimental and Applied Medicine, Section of Cardiovascular Diseases, University of Brescia Medical School, P le Spedali Civili, 1 25123 Brescia, Italy
    Circulation 124:1100-6. 2011
    ..However, their role in the prevention of atrial fibrillation remains controversial...
  20. ncbi A comparison of rate control and rhythm control in patients with atrial fibrillation
    D G Wyse
    AFFIRM Clinical Trial Center, Axio Research, 2601 4th Ave, Ste 200, Seattle, WA 98121, USA
    N Engl J Med 347:1825-33. 2002
    There are two approaches to the treatment of atrial fibrillation: one is cardioversion and treatment with antiarrhythmic drugs to maintain sinus rhythm, and the other is the use of rate-controlling drugs, allowing atrial fibrillation to ..
  21. ncbi Effect of dronedarone on cardiovascular events in atrial fibrillation
    Stefan H Hohnloser
    Department of Cardiology, J W Goethe University, Frankfurt, Germany
    N Engl J Med 360:668-78. 2009
    Dronedarone is a new antiarrhythmic drug that is being developed for the treatment of patients with atrial fibrillation.
  22. ncbi Impact of atrial fibrillation on the risk of death: the Framingham Heart Study
    E J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Mass, USA
    Circulation 98:946-52. 1998
    b>Atrial fibrillation (AF) causes substantial morbidity. It is uncertain whether AF is associated with excess mortality independent of associated cardiac conditions and risk factors.
  23. ncbi Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial
    Jonathan Mant
    Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK
    Lancet 370:493-503. 2007
    Anticoagulants are more effective than antiplatelet agents at reducing stroke risk in patients with atrial fibrillation, but whether this benefit outweighs the increased risk of bleeding in elderly patients is unknown...
  24. ncbi Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Daniel E Singer
    Clinical Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 133:546S-592S. 2008
    This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the American College of Chest Physicians Evidence-Based Guidelines Clinical Practice Guidelines (8th Edition)...
  25. ncbi Electrical, contractile and structural remodeling during atrial fibrillation
    Maurits Allessie
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Cardiovasc Res 54:230-46. 2002
    The natural history of atrial fibrillation (AF) is characterized by a gradual worsening with time...
  26. ncbi Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    Circulation 123:2363-72. 2011
    Dabigatran 150 and 110 mg twice a day and warfarin are effective for stroke prevention in atrial fibrillation. The purpose of this study was to compare their risks of bleeding in the Randomized Evaluation of Long-Term Anticoagulant ..
  27. ncbi Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
    Oral anticoagulation therapy reduces risk of vascular events in patients with atrial fibrillation. However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation...
  28. ncbi C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation
    M K Chung
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 104:2886-91. 2001
    b>Atrial fibrillation (AF) may persist due to structural changes in the atria that are promoted by inflammation. C-reactive protein (CRP), a marker of systemic inflammation, predicts cardiovascular events and stroke, a common sequela of AF...
  29. ncbi Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation
    James V Freeman
    Stanford University School of Medicine, California, USA
    Ann Intern Med 154:1-11. 2011
    Warfarin reduces the risk for ischemic stroke in patients with atrial fibrillation (AF) but increases the risk for hemorrhage...
  30. ncbi A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation
    Isabelle C Van Gelder
    Department of Cardiology, Thoraxcenter, University Hospital, Groningen, The Netherlands
    N Engl J Med 347:1834-40. 2002
    Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm...
  31. ncbi Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study
    Ole Ahlehoff
    Department of Cardiology, Copenhagen University Hospital Gentofte, DK 2900 Hellerup, Denmark
    Eur Heart J 33:2054-64. 2012
    Psoriasis is a chronic inflammatory disease and inflammation contributes to the pathogenesis of atrial fibrillation (AF) and ischaemic stroke. We therefore investigated the risk of these endpoints in patients with psoriasis.
  32. ncbi Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study
    Leif Friberg
    Department of Cardiology, Karolinska Instituet, Danderyd University Hospital, Stockholm, Sweden
    Eur Heart J 33:1500-10. 2012
    ..The impact of some risk factors for stroke and bleeding, and the value of stroke and bleeding risk scores, in atrial fibrillation (AF), has been debated, as clinical trial cohorts have not adequately tested these...
  33. ncbi A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study
    Simon Stewart
    Division of Health Sciences at the University of South Australia, Adelaide, Australia
    Am J Med 113:359-64. 2002
    To describe the effect of atrial fibrillation on long-term morbidity and mortality.
  34. pmc A clinical risk score for atrial fibrillation in a biracial prospective cohort (from the Atherosclerosis Risk in Communities [ARIC] study)
    Alanna M Chamberlain
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 107:85-91. 2011
    A risk score for atrial fibrillation (AF) has been developed by the Framingham Heart Study; however, the applicability of this risk score, derived using data from white patients, to predict new-onset AF in nonwhites is uncertain...
  35. ncbi New ideas about atrial fibrillation 50 years on
    Stanley Nattel
    Department of Medicine, Montreal Heart Institute Research Center, Quebec, Canada
    Nature 415:219-26. 2002
    b>Atrial fibrillation is a condition in which control of heart rhythm is taken away from the normal sinus node pacemaker by rapid activity in different areas within the upper chambers (atria) of the heart...
  36. ncbi Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: resolving uncertainties in routine practice
    Menno V Huisman
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 107:838-47. 2012
    ..approved in Europe for the prevention of stroke or systemic embolism in adult patients with non-valvular atrial fibrillation (AF) and at least one risk factor for stroke...
  37. ncbi Canadian Cardiovascular Society atrial fibrillation guidelines 2010: prevention of stroke and systemic thromboembolism in atrial fibrillation and flutter
    John A Cairns
    University of British Columbia, Vancouver, British Columbia, Canada
    Can J Cardiol 27:74-90. 2011
    The stroke rate in atrial fibrillation is 4.5% per year, with death or permanent disability in over half...
  38. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
    b>Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death...
  39. ncbi Prevention of atrial fibrillation with omega-3 fatty acids: a meta-analysis of randomised clinical trials
    Tong Liu
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Heart 97:1034-40. 2011
    Previous randomised controlled trials (RCT) regarding n-3 PUFA supplementation for atrial fibrillation (AF) prevention have yielded conflicting results.
  40. pmc Recent advances in the molecular pathophysiology of atrial fibrillation
    Reza Wakili
    Research Center, Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Clin Invest 121:2955-68. 2011
    b>Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality...
  41. ncbi Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins
    Svetlana N Reilly
    Department of Cardiovascular Medicine, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 124:1107-17. 2011
    An altered nitric oxide-redox balance has been implicated in the pathogenesis of atrial fibrillation (AF)...
  42. ncbi Dronedarone in high-risk permanent atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
    N Engl J Med 365:2268-76. 2011
    Dronedarone restores sinus rhythm and reduces hospitalization or death in intermittent atrial fibrillation. It also lowers heart rate and blood pressure and has antiadrenergic and potential ventricular antiarrhythmic effects...
  43. ncbi A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: the DIONYSOS study
    Jean Yves Le Heuzey
    Cardiologie A et rythmologie, Hopital Europeen Georges Pompidou, Paris, France
    J Cardiovasc Electrophysiol 21:597-605. 2010
    We compared the efficacy and safety of amiodarone and dronedarone in patients with persistent atrial fibrillation (AF).
  44. ncbi Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
    Ulrich Schotten
    Department of Physiology, University Maastricht, Maastricht, The Netherlands
    Physiol Rev 91:265-325. 2011
    b>Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different pathophysiological processes in the atria...
  45. ncbi Increasing prevalence of atrial fibrillation and flutter in the United States
    Gerald V Naccarelli
    Pennsylvania State Heart and Vascular Institute, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania, USA
    Am J Cardiol 104:1534-9. 2009
    The prevalence data for atrial fibrillation (AF) are dated. The present retrospective study estimated the current and projected prevalence of AF and atrial flutter (AFL) in the United States using a large national database...
  46. pmc Common variants in KCNN3 are associated with lone atrial fibrillation
    Patrick T Ellinor
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 4 These authors contributed equally to this work
    Nat Genet 42:240-4. 2010
    b>Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF...
  47. ncbi Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation
    Brett Burstein
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, and Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 51:802-9. 2008
    b>Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting, and traditional pharmacological approaches have proved to have important weaknesses...
  48. pmc Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study
    Jason H Y Wu
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 125:1084-93. 2012
    ..studies suggest that long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) may reduce the risk of atrial fibrillation (AF)...
  49. ncbi Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: a randomized trial
    Gregory W Albers
    Stanford Stroke Center, Palo Alto, Calif, USA
    JAMA 293:690-8. 2005
    In patients with nonvalvular atrial fibrillation, warfarin prevents ischemic stroke, but dose adjustment, coagulation monitoring, and bleeding limit its use.
  50. ncbi KCNQ1 gain-of-function mutation in familial atrial fibrillation
    Yi Han Chen
    Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People s Republic of China
    Science 299:251-4. 2003
    b>Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood...
  51. ncbi Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation
    Riccardo Cappato
    Arrhythmias and Electrophysiology Center, IRCCS, Policlinico San Donato, Milan, Italy
    Circ Arrhythm Electrophysiol 3:32-8. 2010
    The purpose of this study was to provide an updated worldwide report on the methods, efficacy, and safety of catheter ablation of atrial fibrillation (AF).
  52. ncbi Cost-effectiveness of rivaroxaban compared to warfarin for stroke prevention in atrial fibrillation
    Soyon Lee
    University of Connecticut School of Pharmacy, Storrs, CT, USA
    Am J Cardiol 110:845-51. 2012
    ..found to be noninferior to warfarin for preventing stroke or systemic embolism in patients with high-risk atrial fibrillation (AF) and is associated with a lower rate of intracranial hemorrhage...
  53. pmc Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Study, Framingham, Mass, USA
    Circulation 121:200-7. 2010
    Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial.
  54. ncbi Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation
    Lars Wallentin
    Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjolds vag 14B, Uppsala, Sweden
    Circulation 127:2166-76. 2013
    In the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial, apixaban compared with warfarin reduced stroke and systemic embolism, major bleeding, and mortality...
  55. ncbi Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial
    Robert G Hart
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Stroke 43:1511-7. 2012
    ..Intracranial hemorrhage is the most devastating complication of anticoagulation. Outcomes associated with different sites of intracranial bleeding occurring with warfarin versus dabigatran have not been defined...
  56. ncbi The use of dabigatran immediately after atrial fibrillation ablation
    Roger A Winkle
    Cardiovascular Medicine and Cardiac Arrhythmias, E Palo Alto, Sequoia Hospital, Redwood City, California, USA
    J Cardiovasc Electrophysiol 23:264-8. 2012
    b>Atrial fibrillation (AF) ablation requires postprocedural anticoagulation to prevent thromboembolic events because of the ablation procedure itself or due to recurrent AF postprocedure...
  57. ncbi 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
    Hugh Calkins
    Johns Hopkins Hospital, Baltimore, MD, USA
    J Interv Card Electrophysiol 33:171-257. 2012
    This is a report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation, developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European ..
  58. ncbi Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control
    Allan C Skanes
    Arrhythmia Service, University Hospital, University of Western Ontario, London, Ontario, Canada
    Can J Cardiol 28:125-36. 2012
    The Canadian Cardiovascular Society (CCS) published the complete set of 2010 Atrial Fibrillation (AF) Guidelines in the January, 2011 issue of the Canadian Journal of Cardiology...
  59. ncbi Rivaroxaban: population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention
    Wolfgang Mueck
    Bayer HealthCare, Wuppertal, Germany
    Clin Pharmacokinet 50:675-86. 2011
    ..Exposure simulations in patients with atrial fibrillation (AF) were also performed in order to predict the exposure of rivaroxaban, using modified demographic data ..
  60. ncbi Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drug
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, England
    J Am Coll Cardiol 57:173-80. 2011
    ..The purpose of this study was to investigate predictors of bleeding in a cohort of anticoagulated patients and to evaluate the predictive value of several bleeding risk stratification schemas...
  61. ncbi Estimation of total incremental health care costs in patients with atrial fibrillation in the United States
    Michael H Kim
    Division of Cardiology, Northwestern University, Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611, USA
    Circ Cardiovasc Qual Outcomes 4:313-20. 2011
    Detailed information on the cost burden of atrial fibrillation (AF) is limited...
  62. ncbi Anticoagulation control in Sweden: reports of time in therapeutic range, major bleeding, and thrombo-embolic complications from the national quality registry AuriculA
    Mattias Wieloch
    Department of Clinical Sciences, Malmo, Lund University, Sweden
    Eur Heart J 32:2282-9. 2011
    ..AuriculA, the Swedish national quality registry for atrial fibrillation and anticoagulation, is used for follow-up and dosage control of warfarin...
  63. ncbi Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial
    David J Wilber
    Cardiovascular Institute, Department of Medicine, Loyola University Medical Center, 2160 S First Ave, Bldg 110, Room 6232, Maywood, IL 60153, USA
    JAMA 303:333-40. 2010
    Antiarrhythmic drugs are commonly used for prevention of recurrent atrial fibrillation (AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been proposed as an alternative treatment for paroxysmal AF.
  64. ncbi New antiarrhythmic drugs for treatment of atrial fibrillation
    Dobromir Dobrev
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Lancet 375:1212-23. 2010
    Inadequacies in current therapies for atrial fibrillation have made new drug development crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia...
  65. ncbi Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial
    Lars Wallentin
    Uppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden
    Lancet 376:975-83. 2010
    ..We aimed to investigate the primary and secondary outcomes of the RE-LY trial in relation to each centre's mean TTR (cTTR) in the warfarin population...
  66. ncbi Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    b>Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated.
  67. pmc Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study
    Jonas Bjerring Olesen
    Department of Cardiology, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
    BMJ 342:d124. 2011
    ....
  68. ncbi Enhanced detection of paroxysmal atrial fibrillation by early and prolonged continuous holter monitoring in patients with cerebral ischemia presenting in sinus rhythm
    Raoul Stahrenberg
    Department of Cardiology and Pneumology, Universitatsmedizin Gottingen, 37075 Gottingen, Germany
    Stroke 41:2884-8. 2010
    Diagnosis of paroxysmal atrial fibrillation is difficult but highly relevant in patients presenting with cerebral ischemia yet free from atrial fibrillation on admission...
  69. ncbi Cost-effectiveness of dabigatran for stroke prophylaxis in atrial fibrillation
    Shimoli V Shah
    Department of Medicine, Washington University School of Medicine, Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circulation 123:2562-70. 2011
    Recent studies have investigated alternatives to warfarin for stroke prophylaxis in patients with atrial fibrillation (AF), but whether these alternatives are cost-effective is unknown.
  70. pmc Trends in the prevalence of diagnosed atrial fibrillation, its treatment with anticoagulation and predictors of such treatment in UK primary care
    S DeWilde
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Heart 92:1064-70. 2006
    To examine trends in the prevalence of diagnosed atrial fibrillation (AF), its treatment with oral anticoagulants between 1994 and 2003, and predictors of anticoagulant treatment in 2003.
  71. ncbi ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee fo
    Valentin Fuster
    France
    Europace 8:651-745. 2006
  72. ncbi Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
    b>Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality.
  73. ncbi Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
    b>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria...
  74. ncbi N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial
    Leonardo Calo
    Department of Cardiac Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 45:1723-8. 2005
    ..of this study was to assess the efficacy of preoperative and postoperative treatment with n-3 polyunsaturated fatty acids (PUFAs) in preventing the occurrence of atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG).
  75. ncbi Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation
    Elaine M Hylek
    Research Unit, Section of General Internal Medicine, Boston University School of Medicine, Boston Medical Center, 91 East Concord St, Suite 200, Boston, MA 02118, USA
    Circulation 115:2689-96. 2007
    Warfarin is effective in the prevention of stroke in atrial fibrillation but is under used in clinical care. Concerns exist that published rates of hemorrhage may not reflect real-world practice...
  76. ncbi Atrial fibrillation management: a prospective survey in ESC member countries: the Euro Heart Survey on Atrial Fibrillation
    Robby Nieuwlaat
    Department of Cardiology, University Hospital Maastricht, P Debyelaan 25, PO Box 5800, Maastricht 6202AZ, Maastricht, The Netherlands
    Eur Heart J 26:2422-34. 2005
    To describe atrial fibrillation (AF) management in member countries of the European Society of Cardiology (ESC) and to verify cardiology practices against guidelines.
  77. ncbi Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range
    Stuart J Connolly
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Circulation 118:2029-37. 2008
    Oral anticoagulation (OAC) therapy is effective in atrial fibrillation but requires vigilance to maintain the international normalized ratio in the therapeutic range...
  78. pmc Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Alvaro Alonso
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd Street, Minneapolis, MN 55454 USA
    Am Heart J 158:111-7. 2009
    To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans.
  79. ncbi Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Physiol Rev 87:425-56. 2007
    ..three important clinical and experimental paradigms: congestive heart failure, myocardial infarction, and atrial fibrillation. We pay particular attention to K+, Na+, and Ca2+ channels; Ca2+ transporters; connexins; and ..
  80. ncbi Addressing between-study heterogeneity and inconsistency in mixed treatment comparisons: Application to stroke prevention treatments in individuals with non-rheumatic atrial fibrillation
    Nicola J Cooper
    Department of Health Sciences, University of Leicester, Leicester, U K
    Stat Med 28:1861-81. 2009
    ..and applied to a 17-treatment network for stroke prevention treatments in individuals with non-rheumatic atrial fibrillation.The paper demonstrates the feasibility of incorporating covariates within a mixed treatment comparison ..
  81. ncbi Feasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registry
    Dhanunjaya Lakkireddy
    Division of Cardiovascular Diseases, Cardiovascular Research Institute, Mid America Cardiology, University of Kansas Hospital and Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7200, USA
    J Am Coll Cardiol 59:1168-74. 2012
    The purpose of this study was to evaluate the feasibility and safety of periprocedural dabigatran during atrial fibrillation (AF) ablation.
  82. ncbi MicroRNA expression signature in atrial fibrillation with mitral stenosis
    Junjie Xiao
    Key Laboratory of Arrhythmias, Ministry of Education, Department of Cardiology, East Hospital, Tongji University School of Medicine, Shanghai, China
    Physiol Genomics 43:655-64. 2011
    The aim of this study was to investigate the microRNA (miRNA) signature in atrial fibrillation (AF) with mitral stenosis (MS)...
  83. ncbi Pericardial fat is associated with atrial fibrillation severity and ablation outcome
    Christopher X Wong
    Centre for Heart Rhythm Disorders CHRD, Royal Adelaide Hospital and the University of Adelaide, Adelaide, Australia
    J Am Coll Cardiol 57:1745-51. 2011
    The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF).
  84. ncbi MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation
    Yanjie Lu
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, PR China
    Circulation 122:2378-87. 2010
    A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca(2+) current and shortening of the action potential duration...
  85. ncbi Bleeding risk in very old patients on vitamin K antagonist treatment: results of a prospective collaborative study on elderly patients followed by Italian Centres for Anticoagulation
    Daniela Poli
    Thrombosis Centre Department of Heart and Vessels, AOU Careggi, Florence, Italy
    Circulation 124:824-9. 2011
    ..VKA) therapy is increasingly being used for the prevention of venous thromboembolism and stroke in atrial fibrillation. Bleeds are the major concern for VKA prescription, especially in very old patients who carry many risk ..
  86. pmc Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation
    Eleonora Grandi
    Department of Pharmacology, University of California, Davis, 451 Health Sciences Dr, GBSF Room 3513, Davis, CA 95616 8636, USA
    Circ Res 109:1055-66. 2011
    Understanding atrial fibrillation (AF) requires integrated understanding of ionic currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited.
  87. ncbi European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
    Hein Heidbuchel
    Department of Cardiovascular Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Europace 15:625-51. 2013
    ..NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with non-valvular atrial fibrillation (AF)...
  88. pmc Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007
    Jonathan P Piccini
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Circ Cardiovasc Qual Outcomes 5:85-93. 2012
    b>Atrial fibrillation (AF) is a common and costly problem among older persons. The frequency of AF increases with age, but representative national data about incidence and prevalence are limited...
  89. pmc Cost-effectiveness of apixaban vs warfarin for secondary stroke prevention in atrial fibrillation
    Hooman Kamel
    Department of Neurology and Neuroscience, Weill Cornell Medical College, USA
    Neurology 79:1428-34. 2012
    To compare the cost-effectiveness of apixaban vs warfarin for secondary stroke prevention in patients with atrial fibrillation (AF).
  90. pmc MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation
    Xiaobin Luo
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    J Clin Invest 123:1939-51. 2013
    b>Atrial fibrillation (AF) is a highly prevalent arrhythmia with pronounced morbidity and mortality...
  91. ncbi Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials
    Kazem Rahimi
    George Centre for Healthcare Innovation, University of Oxford, Oxford, UK
    BMJ 342:d1250. 2011
    To examine whether statins can reduce the risk of atrial fibrillation.
  92. pmc Association between familial atrial fibrillation and risk of new-onset atrial fibrillation
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    JAMA 304:2263-9. 2010
    Although the heritability of atrial fibrillation (AF) is established, the contribution of familial AF to predicting new-onset AF remains unknown.
  93. ncbi Risks of thromboembolism and bleeding with thromboprophylaxis in patients with atrial fibrillation: A net clinical benefit analysis using a 'real world' nationwide cohort study
    Jonas Bjerring Olesen
    Department of Cardiology, Post 635, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Thromb Haemost 106:739-49. 2011
    ..and safety of vitamin K antagonists (VKAs) and acetylsalicylic acid (ASA) in patients with non-valvular atrial fibrillation (AF), with separate analyses according to predicted thromboembolic and bleeding risk...
  94. ncbi Effect of dietary fish oil on atrial fibrillation after cardiac surgery
    Aaron L Farquharson
    Discipline of Medicine, University of Adelaide, Adelaide, Australia
    Am J Cardiol 108:851-6. 2011
    An open-label study reported that ingestion of a fish oil concentrate decreased the incidence of atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery...
  95. pmc Dietary ω3 fatty acids modulate the substrate for post-operative atrial fibrillation in a canine cardiac surgery model
    Fadia Mayyas
    Department of Molecular Cardiology, NE 61 Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cardiovasc Res 89:852-61. 2011
    ..dietary ω3 polyunsaturated fatty acids (ω3-PUFA) has been reported to reduce the incidence of new-onset atrial fibrillation (AF) following cardiac surgery...
  96. pmc Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation
    Anuraag R Kansal
    United BioSource Corporation, Bethesda, Maryland, USA
    Heart 98:573-8. 2012
    To assess the cost-effectiveness of dabigatran etexilate, a new oral anticoagulant, versus warfarin and other alternatives for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation (AF).
  97. ncbi Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion
    Rangadham Nagarakanti
    Louisiana State University School of Medicine, New Orleans, LA, USA
    Circulation 123:131-6. 2011
    The Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial compared dabigatran 110 mg BID (D110) and 150 mg BID (D150) with warfarin for stroke prevention in 18 113 patients with nonvalvular atrial fibrillation.
  98. ncbi Myocardial ischemic events in patients with atrial fibrillation treated with dabigatran or warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial
    Stefan H Hohnloser
    Division of Clinical Electrophysiology, J W Goethe University Hospital, Theodor Stern Kai 7, Frankfurt, Germany
    Circulation 125:669-76. 2012
    There is a modest risk of myocardial infarction (MI) and myocardial ischemic events in patients with atrial fibrillation.
  99. ncbi Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation
    Michael H Gollob
    Arrhythmia Research Laboratory and Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada
    N Engl J Med 354:2677-88. 2006
    b>Atrial fibrillation is the most common type of cardiac arrhythmia and a leading cause of cardiovascular morbidity, particularly stroke...
  100. ncbi Preoperative n-3 polyunsatured fatty acids are associated with a decrease in the incidence of early atrial fibrillation following cardiac surgery
    Giovanni Mariscalco
    Department of Surgical Sciences, Cardiac Surgery Unit, Varese University Hospital, University of Insubria, Varese, Italy
    Angiology 61:643-50. 2010
    b>Atrial fibrillation (AF) after cardiac surgery is associated with increased mortality, morbidity, and expenditure. Controversial data exist on possible preventive effects of n-3 polyunsatured fatty acids (PUFAs) against postoperative AF...

Research Grants73

  1. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..Such interactions result in the reduction of inward rectifier currents, and lead to the termination of atrial fibrillation (AF) and VF...
  2. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..Such interactions result in the reduction of inward rectifier currents, and lead to the termination of atrial fibrillation (AF) and VF...
  3. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  4. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
    ..to SERCA ratio will affect atrial function and predispose the atria to develop atrial pathology including atrial fibrillation upon increased load or stress...
  5. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    ..by applicant): The large majority of older patients with autoimmune Graves'hyperthyroidism and atrial fibrillation (AF) have coexisting activating autoantibodies (AA) to the beta1-adrenergic (B1AR) and M2 muscarinic ..
  6. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  7. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    b>Atrial fibrillation (AF) is the most common arrhythmia affecting over 2 million Americans, and is associated with an increased risk of stroke, dementia, heart failure and death...
  8. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with more than 2 million Americans affected, and is growing exponentially...
  9. Angiotensin converting enzyme, angiotensin II, and arrhythmia
    Samuel C Dudley; Fiscal Year: 2010
    ..This application presents a novel hypothesis about why RAS activation causes arrhythmias, contributing to atrial fibrillation (AF) and heart failure (HF)-associated sudden death.
  10. Epidemiologic Study of Sick Sinus Syndrome
    Alvaro Alonso; Fiscal Year: 2012
    ..incidence with the subsequent risk of other cardiovascular outcomes (coronary heart disease, heart failure, atrial fibrillation) and total mortality...
  11. Low energy ventricular defibrillator
    Qun Sha; Fiscal Year: 2012
    ..The "virtual electrode polarization" (VEP) concept has been proposed as a mechanism sustaining atrial fibrillation (AF) and demonstrated in experimental optical mapping of transmembrane potential studies in vitro and in ..
  12. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    EMELIA J contact BENJAMIN; Fiscal Year: 2010
    ..b>Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, affecting more than 2 million ..
  13. The Race-Specific Prevalence of Atrial Fibrillation Measured by 48-Hour Holter
    LAURA L LOEHR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide and it is a known risk factor for stroke...
  14. HCMR Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
    Stefan Neubauer; Fiscal Year: 2013
    ..Secondary endpoints include all- cause mortality, ventricular tachyarrhythmias, hospitalization for heart failure, atrial fibrillation, and stroke.
  15. Minimally Invasive Surgical Pulmonary Vein Insolation vs. Medical Management in P
    MICHAEL FARRIS WATERS; Fiscal Year: 2010
    ..Broad challenge area (05) Comparative Effectiveness Research and specific Challenge 05-HL-101* Treatment of Atrial Fibrillation. Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting over 2...
  16. Role of ankyrin-B in human arrhythmia
    Peter J Mohler; Fiscal Year: 2013
    ..Phenotypes may include sinus node dysfunction, atrial fibrillation (AF), conduction defects, catecholamine-induced polymorphic ventricular arrhythmia, and/or sudden cardiac ..
  17. Cyclic nucleotide permeability of connexin mutants related to genetic disease
    Virginijus Valiunas; Fiscal Year: 2013
    ..In another case, Cx40 mutations have been correlated with atrial fibrillation and other arrhythmias...
  18. Atrial Fibrillation: Bridging genetic discovery and clinical associations
    Steven A Lubitz; Fiscal Year: 2013
    ..Over the last four years the candidate has studied the epidemiology and genetics of atrial fibrillation (AF), achieved a Master of Public Health degree, completed cardiac electrophysiology training, and ..
  19. Identification of a Stretch-Activated Channel with a Role in Cardiac Development
    Dipayan Chaudhuri; Fiscal Year: 2013
    ..For example, inhibitors of these currents are effective against atrial fibrillation in animal models, but designing high-affinty drugs will depend on isolating the channels themselves...
  20. Comparative effectiveness of catheter ablation vs medical therapy for atrial fibr
    James Freeman; Fiscal Year: 2013
    ..PROJECT DESCRIPTION Atrial fibrillation (AF) affects over 2...
  21. Structural and Signaling Roles for Cardiac Ankyrin-B
    SHANE CUNHA; Fiscal Year: 2013
    ..to as "ankyrin-B syndrome" and include catecholamine polymorphic ventricular tachycardia, sinus arrhythmia, atrial fibrillation, and delayed conduction/conduction block...
  22. Genomics of Cardiac Electrical Activity and Arrhythmia
    Nona Sotoodehnia; Fiscal Year: 2013
    ..in cardiac conduction and repolarization can lead to cardiac arrhythmias and adverse outcomes (atrial fibrillation and sudden cardiac death) and can necessitate the placement of cardiac pacemakers and / or defibrillators...
  23. Effect of Statins and Modifiable Factors on Stroke Outcome in Atrial Fibrillation
    Elaine Hylek; Fiscal Year: 2012
    ..S. Cardioembolic strokes resulting from atrial fibrillation (AF) are particularly devastating, with a 30-day mortality of 25%...
  24. A multiethnic comparative effectiveness study for diagnosis of cardiogenic stroke
    Jeffrey R Gulcher; Fiscal Year: 2011
    ..b>Atrial fibrillation (AF) is known to be a major cause of stroke involved in at least 20% of all ischemic strokes (cardiogenic ..
  25. Cardiovascular Inflammation Reduction Trial (CIRT): DCC
    Robert J Glynn; Fiscal Year: 2013
    ..Secondary endpoints include diabetes, venous thrombosis, and atrial fibrillation, all of which have an inflammatory basis...
  26. Cardiovascular Inflammation Reduction Trial (CIRT)
    Paul M Ridker; Fiscal Year: 2013
    ..Secondary endpoints include diabetes, venous thrombosis, and atrial fibrillation, all of which have an inflammatory basis...
  27. Arterial Structure and Function and Atrial Fibrillation
    Lin Yee Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, reaching epidemic proportions in the aging population and causing considerable morbidity, mortality, and socioeconomic burden...
  28. JNK Suppression of Connexin43 Enhances Atrial Fibrillation in Aged Atria
    Xun Ai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common arrhythmia and causes an increased risk of mortality and significant morbidity (such as stroke and heart failure (HF))...
  29. Impact of Atrial Fibrillation and Surgical Ablation on Atrial Function
    JASON OWEN ROBERTSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common of all cardiac arrhythmias, afflicting nearly 5.5 million people worldwide...
  30. Mitochondrial Dysfunction and Susceptibility to Atrial Fibrillation in the Elderl
    Arshad Jahangir; Fiscal Year: 2013
    ..is to obtain mechanistic insights into the role of cardiac mitochondria in defining the substrate for atrial fibrillation (AF), the most common arrhythmia encountered in clinical practice...
  31. Predisposing Factors for the Development of Atrial Fibrillation Among Women
    Christine M Albert; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. At present, an estimated 2...
  32. Phosphorylation of cMyBP-C Modulates Cardiac Arrhythmias
    Ramzi J Khairallah; Fiscal Year: 2013
    ..in the healthy heart and severely depleted in HF, pathological hypertrophy, ischemic injury and atrial fibrillation. The planned investigation will exploit well established methods of assessing cardiac function in vivo, as ..
  33. Dual Use: Safe in Atrial Fibrillation?
    MINANG PRAVIN TURAKHIA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In the course of completing our study, "Stroke Prevention in Atrial Fibrillation: Impact of Mental Illness" (IIR 04- 248), we learned that half of Veterans receiving warfarin in VA actually received ..
  34. Epidemiologic Study of Risk Factors and Biomarkers of Atrial Fibrillation
    Alvaro Alonso; Fiscal Year: 2010
    ..b>Atrial fibrillation (AF) is the most frequent cardiac arrhythmia in clinical practice...
  35. Risks of Warfarin for Elders with Atrial Fibrillation
    Margaret C Fang; Fiscal Year: 2010
    ..Dr. Fang's overall career goal is to optimize stroke prevention in older patients with atrial fibrillation. She will develop a research program that will explore clinical and biological risk factors for stroke and ..
  36. Patterns of Health Care Use, Treatment &Outcomes in Atrial Fibrillation: PATH-AF
    SUSAN HECKBERT; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is a major source of cardiovascular disease morbidity and mortality and an important public health problem. It is estimated that the prevalence of AF in the U.S...
  37. FASEB SRC on The Biology of Calpains in Health and Disease
    James W Geddes; Fiscal Year: 2013
    ..discussed at the this meeting will include aging, Alzheimer's disease, amyotrophic lateral sclerosis, atrial fibrillation, cardiac ischemic injury, cerebral ischemia, cardiac hypertrophy, diabetes, Machado-Joseph disease, malaria,..
  38. Prolonged Clopidogrel Use After Drug-Eluting and Bare-Metal Coronary Stenting
    Scott Kinlay; Fiscal Year: 2013
    ..g. atrial fibrillation)...
  39. Cardiac Magnetic Resonance IMaging During Arrhythmia
    Aravindan Kolandaivelu; Fiscal Year: 2013
    ..While many tachy-arrhythmias are curable by catheter ablation, some common conditions, in particular atrial fibrillation and ventricular tachycardia (VT), are sub-optimally managed by current medical and ablation treatments...
  40. Climate Change and Cardiac Vulnerability in Humans
    Antonella Zanobetti; Fiscal Year: 2012
    ..precisely collected data on multiple pollutant exposures, and cardiovascular (blood pressure, paroxysmal atrial fibrillation, ventricular tachycardia) and cerebrovascular outcomes (stroke) in Eastern Massachusetts, we will partner ..
  41. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2013
    ..second aim, we will examine the relationship between persistent subclinical hyperthyroidism and incident atrial fibrillation, hip fracture, and dementia, and in our third aim, we will examine the relationship between persistent ..
  42. Determining the Role of the Potassium Channel, KCNN3, in Atrial Fibrillation
    PATRICK THOMAS ELLINOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common arrhythmia and affects over 2 million Americans...
  43. gp130 Cytokines, Diabetic Autonomic Neuropathy, and Nerve Regeneration
    Richard E Zigmond; Fiscal Year: 2013
    ..diabetic autonomic neuropathy (DAN), is common and can lead to a wide range of conditions such as atrial fibrillation, stroke, and sudden unexplained cardiac death, making the development of treatments imperative...
  44. Preamyloid Oligomers and Susceptibility to Atrial Fibrillation
    Katherine T Murray; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common cardiac arrhythmia, resulting in substantial morbidity and mortality...
  45. Improved Targeting and Assessment of Electrophysiology Intervention
    Henry R Halperin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) and ventricular tachycardia (VT) affect millions of patients in the United States. These arrhythmias can be cured with catheter ablation, but the arrhythmias often recur...
  46. The Atrial Fibrillation - Factor Identification to Risk Modification Study in HD
    WOLFGANG CHRISTOPH WINKELMAYER; Fiscal Year: 2013
    ..that patients undergoing hemodialysis, especially those who are older, are at particular risk to have atrial fibrillation. Atrial fibrillation is associated with poor outcomes including high mortality (40% per year)...
  47. C-Arm CT for Guidence of Cardiac Interventions
    Rebecca Fahrig; Fiscal Year: 2010
    ..One of the fastest growing procedures is ablation for treatment of atrial fibrillation - a problem eventually suffered by 20% of the population and a significant contributor to stroke, patient ..
  48. The Role of Obstructive Sleep Apnea in the Acutely Decompensated Heart Failure
    Rami Khayat; Fiscal Year: 2009
    ..may particularly be implicated in the acute decompensation of heart failure, a condition often triggered by atrial fibrillation, CAD or hypertension...
  49. Determinants of fall-related bleeding among older adults with atrial fibrillation
    John A Dodson; Fiscal Year: 2013
    ..Dring the award period, the applicant will also pursue coursework in biostatistics and epidemiology that will be applied towards an MPH degree. ..
  50. Factors Associated with Warfarin Use in Dialysis Patients w/ Atrial Fibrillation
    JAMES BACON WETMORE; Fiscal Year: 2013
    ..Chronic atrial fibrillation (AF), common in the dialysis population, is a potentially-modifiable stroke risk factor...
  51. Endovascular Cardiac Optical Mapping
    Christian S Eversull; Fiscal Year: 2013
    ..For example, in pulmonary vein isolation for atrial fibrillation, although this is largely an anatomically based procedure, direct visualization alone cannot readily ..
  52. Percutaneous cardiac HIFU ablation with multimodal image guidance
    Douglas N Stephens; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, with an estimated prevalence of 0.4% to 1% in the general population, increasing with age (8% for people over 80)...
  53. Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC Cohort
    Pamela L Lutsey; Fiscal Year: 2013
    ..whether levels of 25(OH)D, PTH, and FGF23 are related to risk of incident coronary heart disease, stroke, atrial fibrillation, congestive heart failure, and peripheral artery disease...
  54. Positional Cloning and Candidate Gene Approach to Familial Atrial Fibrilation
    Dawood Darbar; Fiscal Year: 2012
    Abstract Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice, reaching epidemic proportions in the aging U.S. population...
  55. Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
    DANIEL EDWIN SINGER; Fiscal Year: 2010
    ..RC2) and specifically responds to the NHLBI RC2 topic of Comparative Effectiveness among adults with atrial fibrillation. Atrial fibrillation is the most common clinically significant arrhythmia in adults and one of the most ..
  56. PROTOTYPE CATHETER FOR IN VIVO HIGH-RESOLUTION CARDIAC FLUORESCENCE MAPPING
    Miguel Valderrabano; Fiscal Year: 2010
    ..Aim #3 is to delineate, in pigs, the role of pulmonary vein activations in cholinergic atrial fibrillation in vivo as a first validation of the technique...
  57. MOLECULAR BASIS FOR Kv CHANNEL HETEROGENEITY IN THE HEART
    Gea Ny Tseng; Fiscal Year: 2010
    ..repolarization and increased risk for arrhythmias (long &short QT syndromes, LQT &SQT, and familial atrial fibrillation, fAF)...
  58. E-C Coupling and Ca2+ Regulation in atrial myocytes
    Lothar A Blatter; Fiscal Year: 2012
    Cardiac arrhythmias, including atrial fibrillation, are a high risk factor for stroke and sudden cardiac death. Cardiac alternans is a key arrhythmogenic factor predisposing the heart to re-entry and lethal arrhythmias...
  59. INTERCELLULAR COMMUNICATION AND IMPULSE PROPAGATION
    JOSE S JALIFE; Fiscal Year: 2010
    ..In Project 1. we propose to translate fundamental knowledge on mechanisms of atrial fibrillation (AF) into an understanding of AF in humans...
  60. BRIDGE TRIAL
    Thomas L Ortel; Fiscal Year: 2013
    ..We hypothesize that simply withholding warfarin in the perioperative setting for patients with atrial fibrillation will not meaningfully increase the risk for arterial thromboembolism, and will forestall hemorrhagic ..
  61. BRIDGE TRIAL
    Victor Hasselblad; Fiscal Year: 2013
    ..We hypothesize that simply withholding warfarin in the perioperative setting for patients with atrial fibrillation will not meaningfully increase the risk for arterial thromboembolism, and will forestall hemorrhagic ..
  62. Functional Genomics of Atrial Fibrillation in Human Atria
    David R Van Wagoner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) increases risk of heart failure, stroke and death, and AF has been found to have a significant heritable component...
  63. Rapid High-Resolution Electroanatomical Cardiac Mapping System for the Treatment
    DORON HARLEV; Fiscal Year: 2009
    ..b>Atrial fibrillation alone has reached epidemic proportions, estimated to currently afflict ~2.3 million Americans and ~5...
  64. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2006
    ..to assess drug-gene interactions on the outcomes of myocardial infarction (MI), stroke, and new-onset atrial fibrillation (AF). The 3 case groups share a single population-based control group...
  65. Novel 3D Catheter Tracking System for Intracardiac Navigation
    DORON HARLEV; Fiscal Year: 2009
    ..b>Atrial fibrillation alone has reached epidemic proportions, estimated to currently afflict ~2.3 million Americans and ~5...
  66. ELECTRODE DESIGN FOR CARDIAC TACHYARRYTHMIA RF ABLATION
    John Webster; Fiscal Year: 2002
    ..Adapted from Applicant's Abstract): The goal of this study is to optimize catheter design for the cure of atrial fibrillation and ventricular tachycardia by endocardial radiofrequency (RF) ablation...
  67. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    b>Atrial fibrillation is the most prevalent sustained cardiac arrhythmia, affecting over 2 million Americans...
  68. CLOSED-LOOP IMPLANTABLE ANTIARRHYTHMIC DRUG INFUSION
    Robert Arzbaecher; Fiscal Year: 1993
    ..In the previous project period, we developed a system which detects atrial fibrillation and delivers a pharmacokinetically-based infusion of procainamide or disopyramide...
  69. VERY LOW ENERGY CARDIOVERSION FOR ATRIAL FIBRILLATION
    Patrick Wolf; Fiscal Year: 2003
    Internal atrial defibrillation is a successful therapy for the treatment of atrial fibrillation(AF)...
  70. Cardiac Cryoablation Catheter
    RAN YARON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most frequent arrhythmia encountered in clinical practice and is the most common arrhythmia necessitating hospital admission. Nearly three million people in the U.S...
  71. MRI Compatible Electrode Catheter System
    STEVEN WEDAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Atrial fibrillation and ventricular tachyarrhythmias occurring in patients with structurally abnormal hearts are the most important arrhythmias in contemporary cardiology...
  72. Precise Micro-Steerable Mapping and Ablation Catheters for Treatment of Atrial Fi
    DEAN A ANDERSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Arrhythmias are among the most common disorders of the heart. Atrial fibrillation (AFib) is a common arrhythmia associated with significant morbidity. There are currently more than 2...
  73. Homogeneous Transfer of Connexin 43 to Prevent Atrial Fibrillation in Pigs
    Hao Qin; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): As the most common arrhythmia affecting ~2 million Americans, chronic atrial fibrillation (AF) is associated with numerous pathological sequelae such as stroke and tachycardia related ..