atrial fibrillation

Summary

Summary: Disorder of cardiac rhythm characterized by rapid, irregular atrial impulses and ineffective atrial contractions.

Top Publications

  1. doi Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
  2. doi Apixaban versus warfarin in patients with atrial fibrillation
    Christopher B Granger
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    N Engl J Med 365:981-92. 2011
  3. doi Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    Manesh R Patel
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 365:883-91. 2011
  4. ncbi Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
    A S Go
    Division of Research, Kaiser Permanente of Northern California, 3505 Broadway, 12th Floor, Oakland, CA 94611, USA
    JAMA 285:2370-5. 2001
  5. ncbi Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation
    B F Gage
    Division of General Medical Sciences, Washington University School of Medicine Campus, Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    JAMA 285:2864-70. 2001
  6. doi Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    Chest 137:263-72. 2010
  7. doi Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
  8. ncbi Impact of atrial fibrillation on the risk of death: the Framingham Heart Study
    E J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Mass, USA
    Circulation 98:946-52. 1998
  9. ncbi Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 146:857-67. 2007
  10. ncbi ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice
    Valentin Fuster
    Circulation 114:e257-354. 2006

Detail Information

Publications326 found, 100 shown here

  1. doi Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor.
  2. doi Apixaban versus warfarin in patients with atrial fibrillation
    Christopher B Granger
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    N Engl J Med 365:981-92. 2011
    Vitamin K antagonists are highly effective in preventing stroke in patients with atrial fibrillation but have several limitations...
  3. doi Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    Manesh R Patel
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 365:883-91. 2011
    The use of warfarin reduces the rate of ischemic stroke in patients with atrial fibrillation but requires frequent monitoring and dose adjustment...
  4. ncbi Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
    A S Go
    Division of Research, Kaiser Permanente of Northern California, 3505 Broadway, 12th Floor, Oakland, CA 94611, USA
    JAMA 285:2370-5. 2001
    b>Atrial fibrillation is the most common arrhythmia in elderly persons and a potent risk factor for stroke. However, recent prevalence and projected future numbers of persons with atrial fibrillation are not well described.
  5. ncbi Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation
    B F Gage
    Division of General Medical Sciences, Washington University School of Medicine Campus, Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    JAMA 285:2864-70. 2001
    Patients who have atrial fibrillation (AF) have an increased risk of stroke, but their absolute rate of stroke depends on age and comorbid conditions.
  6. doi Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    Chest 137:263-72. 2010
    ..clinical risk stratification schemata for predicting stroke and thromboembolism (TE) in patients with atrial fibrillation (AF) are largely derived from risk factors identified from trial cohorts...
  7. doi Apixaban in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 364:806-17. 2011
    Vitamin K antagonists have been shown to prevent stroke in patients with atrial fibrillation. However, many patients are not suitable candidates for or are unwilling to receive vitamin K antagonist therapy, and these patients have a high ..
  8. ncbi Impact of atrial fibrillation on the risk of death: the Framingham Heart Study
    E J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Mass, USA
    Circulation 98:946-52. 1998
    b>Atrial fibrillation (AF) causes substantial morbidity. It is uncertain whether AF is associated with excess mortality independent of associated cardiac conditions and risk factors.
  9. ncbi Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 146:857-67. 2007
    b>Atrial fibrillation is a strong independent risk factor for stroke.
  10. ncbi ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice
    Valentin Fuster
    Circulation 114:e257-354. 2006
  11. doi A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey
    Ron Pisters
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Chest 138:1093-100. 2010
    Despite extensive use of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and the increased bleeding risk associated with such OAC use, no handy quantification tool for assessing this risk exists...
  12. pmc The net clinical benefit of warfarin anticoagulation in atrial fibrillation
    Daniel E Singer
    Massachusetts General Hospital, Boston, Massachussetts 02114, USA
    Ann Intern Med 151:297-305. 2009
    Guidelines recommend warfarin use in patients with atrial fibrillation solely on the basis of risk for ischemic stroke without antithrombotic therapy...
  13. doi Underuse of oral anticoagulants in atrial fibrillation: a systematic review
    Isla M Ogilvie
    BioMedCom Consultants Inc, Montreal, QC, Canada
    Am J Med 123:638-645.e4. 2010
    b>Atrial fibrillation is associated with substantial mortality and morbidity from stroke and thromboembolism...
  14. ncbi Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    b>Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated.
  15. doi Subclinical atrial fibrillation and the risk of stroke
    Jeff S Healey
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 366:120-9. 2012
    One quarter of strokes are of unknown cause, and subclinical atrial fibrillation may be a common etiologic factor...
  16. ncbi Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence
    Yoko Miyasaka
    Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Circulation 114:119-25. 2006
    Limited data exist on trends in incidence of atrial fibrillation (AF). We assessed the community-based trends in AF incidence for 1980 to 2000 and provided prevalence projections to 2050.
  17. doi n-3 polyunsaturated fatty acids in the prevention of atrial fibrillation recurrences after electrical cardioversion: a prospective, randomized study
    Savina Nodari
    Department of Experimental and Applied Medicine, Section of Cardiovascular Diseases, University of Brescia Medical School, P le Spedali Civili, 1 25123 Brescia, Italy
    Circulation 124:1100-6. 2011
    ..However, their role in the prevention of atrial fibrillation remains controversial...
  18. doi Effect of dronedarone on cardiovascular events in atrial fibrillation
    Stefan H Hohnloser
    Department of Cardiology, J W Goethe University, Frankfurt, Germany
    N Engl J Med 360:668-78. 2009
    Dronedarone is a new antiarrhythmic drug that is being developed for the treatment of patients with atrial fibrillation.
  19. ncbi A comparison of rate control and rhythm control in patients with atrial fibrillation
    D G Wyse
    AFFIRM Clinical Trial Center, Axio Research, 2601 4th Ave, Ste 200, Seattle, WA 98121, USA
    N Engl J Med 347:1825-33. 2002
    There are two approaches to the treatment of atrial fibrillation: one is cardioversion and treatment with antiarrhythmic drugs to maintain sinus rhythm, and the other is the use of rate-controlling drugs, allowing atrial fibrillation to ..
  20. doi Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
    Ulrich Schotten
    Department of Physiology, University Maastricht, Maastricht, The Netherlands
    Physiol Rev 91:265-325. 2011
    b>Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different pathophysiological processes in the atria...
  21. doi Increasing prevalence of atrial fibrillation and flutter in the United States
    Gerald V Naccarelli
    Pennsylvania State Heart and Vascular Institute, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania, USA
    Am J Cardiol 104:1534-9. 2009
    The prevalence data for atrial fibrillation (AF) are dated. The present retrospective study estimated the current and projected prevalence of AF and atrial flutter (AFL) in the United States using a large national database...
  22. ncbi Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial
    Jonathan Mant
    Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK
    Lancet 370:493-503. 2007
    Anticoagulants are more effective than antiplatelet agents at reducing stroke risk in patients with atrial fibrillation, but whether this benefit outweighs the increased risk of bleeding in elderly patients is unknown...
  23. ncbi Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Daniel E Singer
    Clinical Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 133:546S-592S. 2008
    This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the American College of Chest Physicians Evidence-Based Guidelines Clinical Practice Guidelines (8th Edition)...
  24. doi Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    Circulation 123:2363-72. 2011
    Dabigatran 150 and 110 mg twice a day and warfarin are effective for stroke prevention in atrial fibrillation. The purpose of this study was to compare their risks of bleeding in the Randomized Evaluation of Long-Term Anticoagulant ..
  25. ncbi C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation
    M K Chung
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 104:2886-91. 2001
    b>Atrial fibrillation (AF) may persist due to structural changes in the atria that are promoted by inflammation. C-reactive protein (CRP), a marker of systemic inflammation, predicts cardiovascular events and stroke, a common sequela of AF...
  26. pmc Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study
    Jonas Bjerring Olesen
    Department of Cardiology, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
    BMJ 342:d124. 2011
    ....
  27. ncbi Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
    Oral anticoagulation therapy reduces risk of vascular events in patients with atrial fibrillation. However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation...
  28. doi Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation
    James V Freeman
    Stanford University School of Medicine, California, USA
    Ann Intern Med 154:1-11. 2011
    Warfarin reduces the risk for ischemic stroke in patients with atrial fibrillation (AF) but increases the risk for hemorrhage...
  29. ncbi A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation
    Isabelle C Van Gelder
    Department of Cardiology, Thoraxcenter, University Hospital, Groningen, The Netherlands
    N Engl J Med 347:1834-40. 2002
    Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm...
  30. pmc Recent advances in the molecular pathophysiology of atrial fibrillation
    Reza Wakili
    Research Center, Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Clin Invest 121:2955-68. 2011
    b>Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality...
  31. doi Canadian Cardiovascular Society atrial fibrillation guidelines 2010: prevention of stroke and systemic thromboembolism in atrial fibrillation and flutter
    John A Cairns
    University of British Columbia, Vancouver, British Columbia, Canada
    Can J Cardiol 27:74-90. 2011
    The stroke rate in atrial fibrillation is 4.5% per year, with death or permanent disability in over half...
  32. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
    b>Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death...
  33. ncbi Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins
    Svetlana N Reilly
    Department of Cardiovascular Medicine, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 124:1107-17. 2011
    An altered nitric oxide-redox balance has been implicated in the pathogenesis of atrial fibrillation (AF)...
  34. doi Prevention of atrial fibrillation with omega-3 fatty acids: a meta-analysis of randomised clinical trials
    Tong Liu
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Heart 97:1034-40. 2011
    Previous randomised controlled trials (RCT) regarding n-3 PUFA supplementation for atrial fibrillation (AF) prevention have yielded conflicting results.
  35. doi Dronedarone in high-risk permanent atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada
    N Engl J Med 365:2268-76. 2011
    Dronedarone restores sinus rhythm and reduces hospitalization or death in intermittent atrial fibrillation. It also lowers heart rate and blood pressure and has antiadrenergic and potential ventricular antiarrhythmic effects...
  36. doi A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: the DIONYSOS study
    Jean Yves Le Heuzey
    Cardiologie A et rythmologie, Hopital Europeen Georges Pompidou, Paris, France
    J Cardiovasc Electrophysiol 21:597-605. 2010
    We compared the efficacy and safety of amiodarone and dronedarone in patients with persistent atrial fibrillation (AF).
  37. ncbi Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study
    Jan Heeringa
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Heart J 27:949-53. 2006
    We aimed to investigate the prevalence and incidence of atrial fibrillation (AF) in a large European population-based study.
  38. pmc Common variants in KCNN3 are associated with lone atrial fibrillation
    Patrick T Ellinor
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 4 These authors contributed equally to this work
    Nat Genet 42:240-4. 2010
    b>Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF...
  39. ncbi A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study
    Simon Stewart
    Division of Health Sciences at the University of South Australia, Adelaide, Australia
    Am J Med 113:359-64. 2002
    To describe the effect of atrial fibrillation on long-term morbidity and mortality.
  40. ncbi KCNQ1 gain-of-function mutation in familial atrial fibrillation
    Yi Han Chen
    Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People s Republic of China
    Science 299:251-4. 2003
    b>Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood...
  41. ncbi Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: a randomized trial
    Gregory W Albers
    Stanford Stroke Center, Palo Alto, Calif, USA
    JAMA 293:690-8. 2005
    In patients with nonvalvular atrial fibrillation, warfarin prevents ischemic stroke, but dose adjustment, coagulation monitoring, and bleeding limit its use.
  42. doi Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation
    Riccardo Cappato
    Arrhythmias and Electrophysiology Center, IRCCS, Policlinico San Donato, Milan, Italy
    Circ Arrhythm Electrophysiol 3:32-8. 2010
    The purpose of this study was to provide an updated worldwide report on the methods, efficacy, and safety of catheter ablation of atrial fibrillation (AF).
  43. doi Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial
    Lars Wallentin
    Uppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden
    Lancet 376:975-83. 2010
    ..We aimed to investigate the primary and secondary outcomes of the RE-LY trial in relation to each centre's mean TTR (cTTR) in the warfarin population...
  44. doi Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drug
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, England
    J Am Coll Cardiol 57:173-80. 2011
    ..The purpose of this study was to investigate predictors of bleeding in a cohort of anticoagulated patients and to evaluate the predictive value of several bleeding risk stratification schemas...
  45. doi Anticoagulation control in Sweden: reports of time in therapeutic range, major bleeding, and thrombo-embolic complications from the national quality registry AuriculA
    Mattias Wieloch
    Department of Clinical Sciences, Malmo, Lund University, Sweden
    Eur Heart J 32:2282-9. 2011
    ..AuriculA, the Swedish national quality registry for atrial fibrillation and anticoagulation, is used for follow-up and dosage control of warfarin...
  46. ncbi New ideas about atrial fibrillation 50 years on
    Stanley Nattel
    Department of Medicine, Montreal Heart Institute Research Center, Quebec, Canada
    Nature 415:219-26. 2002
    b>Atrial fibrillation is a condition in which control of heart rhythm is taken away from the normal sinus node pacemaker by rapid activity in different areas within the upper chambers (atria) of the heart...
  47. doi Estimation of total incremental health care costs in patients with atrial fibrillation in the United States
    Michael H Kim
    Division of Cardiology, Northwestern University, Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611, USA
    Circ Cardiovasc Qual Outcomes 4:313-20. 2011
    Detailed information on the cost burden of atrial fibrillation (AF) is limited...
  48. ncbi New antiarrhythmic drugs for treatment of atrial fibrillation
    Dobromir Dobrev
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Lancet 375:1212-23. 2010
    Inadequacies in current therapies for atrial fibrillation have made new drug development crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia...
  49. ncbi Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial
    David J Wilber
    Cardiovascular Institute, Department of Medicine, Loyola University Medical Center, 2160 S First Ave, Bldg 110, Room 6232, Maywood, IL 60153, USA
    JAMA 303:333-40. 2010
    Antiarrhythmic drugs are commonly used for prevention of recurrent atrial fibrillation (AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been proposed as an alternative treatment for paroxysmal AF.
  50. doi Enhanced detection of paroxysmal atrial fibrillation by early and prolonged continuous holter monitoring in patients with cerebral ischemia presenting in sinus rhythm
    Raoul Stahrenberg
    Department of Cardiology and Pneumology, Universitatsmedizin Gottingen, 37075 Gottingen, Germany
    Stroke 41:2884-8. 2010
    Diagnosis of paroxysmal atrial fibrillation is difficult but highly relevant in patients presenting with cerebral ischemia yet free from atrial fibrillation on admission...
  51. doi Cost-effectiveness of dabigatran for stroke prophylaxis in atrial fibrillation
    Shimoli V Shah
    Department of Medicine, Washington University School of Medicine, Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circulation 123:2562-70. 2011
    Recent studies have investigated alternatives to warfarin for stroke prophylaxis in patients with atrial fibrillation (AF), but whether these alternatives are cost-effective is unknown.
  52. pmc Trends in the prevalence of diagnosed atrial fibrillation, its treatment with anticoagulation and predictors of such treatment in UK primary care
    S DeWilde
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Heart 92:1064-70. 2006
    To examine trends in the prevalence of diagnosed atrial fibrillation (AF), its treatment with oral anticoagulants between 1994 and 2003, and predictors of anticoagulant treatment in 2003.
  53. ncbi ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee fo
    Valentin Fuster
    France
    Europace 8:651-745. 2006
  54. ncbi N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial
    Leonardo Calo
    Department of Cardiac Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 45:1723-8. 2005
    ..of this study was to assess the efficacy of preoperative and postoperative treatment with n-3 polyunsaturated fatty acids (PUFAs) in preventing the occurrence of atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG).
  55. ncbi Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
    b>Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria...
  56. doi Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials
    Kazem Rahimi
    George Centre for Healthcare Innovation, University of Oxford, Oxford, UK
    BMJ 342:d1250. 2011
    To examine whether statins can reduce the risk of atrial fibrillation.
  57. pmc Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation
    Anuraag R Kansal
    United BioSource Corporation, Bethesda, Maryland, USA
    Heart 98:573-8. 2012
    To assess the cost-effectiveness of dabigatran etexilate, a new oral anticoagulant, versus warfarin and other alternatives for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation (AF).
  58. pmc Dietary ω3 fatty acids modulate the substrate for post-operative atrial fibrillation in a canine cardiac surgery model
    Fadia Mayyas
    Department of Molecular Cardiology, NE 61 Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cardiovasc Res 89:852-61. 2011
    ..dietary ω3 polyunsaturated fatty acids (ω3-PUFA) has been reported to reduce the incidence of new-onset atrial fibrillation (AF) following cardiac surgery...
  59. pmc Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    John J You
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 141:e531S-75S. 2012
    The risk of stroke varies considerably across different groups of patients with atrial fibrillation (AF). Antithrombotic prophylaxis for stroke is associated with an increased risk of bleeding...
  60. pmc Association between familial atrial fibrillation and risk of new-onset atrial fibrillation
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    JAMA 304:2263-9. 2010
    Although the heritability of atrial fibrillation (AF) is established, the contribution of familial AF to predicting new-onset AF remains unknown.
  61. pmc A clinical risk score for atrial fibrillation in a biracial prospective cohort (from the Atherosclerosis Risk in Communities [ARIC] study)
    Alanna M Chamberlain
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 107:85-91. 2011
    A risk score for atrial fibrillation (AF) has been developed by the Framingham Heart Study; however, the applicability of this risk score, derived using data from white patients, to predict new-onset AF in nonwhites is uncertain...
  62. doi Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion
    Rangadham Nagarakanti
    Louisiana State University School of Medicine, New Orleans, LA, USA
    Circulation 123:131-6. 2011
    The Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial compared dabigatran 110 mg BID (D110) and 150 mg BID (D150) with warfarin for stroke prevention in 18 113 patients with nonvalvular atrial fibrillation.
  63. doi Risks of thromboembolism and bleeding with thromboprophylaxis in patients with atrial fibrillation: A net clinical benefit analysis using a 'real world' nationwide cohort study
    Jonas Bjerring Olesen
    Department of Cardiology, Post 635, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Thromb Haemost 106:739-49. 2011
    ..and safety of vitamin K antagonists (VKAs) and acetylsalicylic acid (ASA) in patients with non-valvular atrial fibrillation (AF), with separate analyses according to predicted thromboembolic and bleeding risk...
  64. doi Effect of dietary fish oil on atrial fibrillation after cardiac surgery
    Aaron L Farquharson
    Discipline of Medicine, University of Adelaide, Adelaide, Australia
    Am J Cardiol 108:851-6. 2011
    An open-label study reported that ingestion of a fish oil concentrate decreased the incidence of atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery...
  65. doi Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study
    Ole Ahlehoff
    Department of Cardiology, Copenhagen University Hospital Gentofte, DK 2900 Hellerup, Denmark
    Eur Heart J 33:2054-64. 2012
    Psoriasis is a chronic inflammatory disease and inflammation contributes to the pathogenesis of atrial fibrillation (AF) and ischaemic stroke. We therefore investigated the risk of these endpoints in patients with psoriasis.
  66. doi Myocardial ischemic events in patients with atrial fibrillation treated with dabigatran or warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial
    Stefan H Hohnloser
    Division of Clinical Electrophysiology, J W Goethe University Hospital, Theodor Stern Kai 7, Frankfurt, Germany
    Circulation 125:669-76. 2012
    There is a modest risk of myocardial infarction (MI) and myocardial ischemic events in patients with atrial fibrillation.
  67. ncbi Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation
    Michael H Gollob
    Arrhythmia Research Laboratory and Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada
    N Engl J Med 354:2677-88. 2006
    b>Atrial fibrillation is the most common type of cardiac arrhythmia and a leading cause of cardiovascular morbidity, particularly stroke...
  68. ncbi Preoperative n-3 polyunsatured fatty acids are associated with a decrease in the incidence of early atrial fibrillation following cardiac surgery
    Giovanni Mariscalco
    Department of Surgical Sciences, Cardiac Surgery Unit, Varese University Hospital, University of Insubria, Varese, Italy
    Angiology 61:643-50. 2010
    b>Atrial fibrillation (AF) after cardiac surgery is associated with increased mortality, morbidity, and expenditure. Controversial data exist on possible preventive effects of n-3 polyunsatured fatty acids (PUFAs) against postoperative AF...
  69. ncbi Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the Strategies of Treatment of Atrial Fibrillation (STAF) study
    Jorg Carlsson
    Department of Internal Medicine II, Klinikum Lippe Detmold, Röntgenstrasse 18, D 32760 Detmold, Germany
    J Am Coll Cardiol 41:1690-6. 2003
    This study was designed to compare two treatment strategies in patients with atrial fibrillation(AF): rhythm-control (restoration and maintenance of sinus rhythm) and rate-control (pharmacologic or invasive rate-control and ..
  70. doi Does treatment with n-3 polyunsaturated fatty acids prevent atrial fibrillation after open heart surgery?
    Ragnhildur Heidarsdottir
    Department of Physiology, School of Health Sciences, University of Iceland, Reykjavik, Iceland
    Europace 12:356-63. 2010
    To examine the effect of n-3 polyunsaturated fatty acid (PUFA) treatment on the incidence of post-operative atrial fibrillation (POAF).
  71. ncbi Rhythm or rate control in atrial fibrillation--Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trial
    S H Hohnloser
    JW Goethe University, Frankfurt, Germany
    Lancet 356:1789-94. 2000
    b>Atrial fibrillation is the most commonly encountered sustained cardiac arrhythmia. Restoration and maintenance of sinus rhythm is believed by many physicians to be superior to rate control only...
  72. ncbi HRS/EHRA/ECAS expert Consensus Statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) Task Force on catheter and surgical ablation of
    Hugh Calkins
    Johns Hopkins Hospital, Maryland, USA
    Heart Rhythm 4:816-61. 2007
  73. doi n-3 polyunsaturated fatty acids for the prevention of arrhythmia recurrence after electrical cardioversion of chronic persistent atrial fibrillation: a randomized, double-blind, multicentre study
    Leopoldo Bianconi
    Department of Cardiology, San Filippo Neri Hospital, University of Tor Vergata, Rome, Italy
    Europace 13:174-81. 2011
    Persistent atrial fibrillation (AF) often recurs after direct current electrical cardioversion (ECV)...
  74. pmc Dietary fish intake and incident atrial fibrillation (from the Women's Health Initiative)
    Jarett D Berry
    Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Am J Cardiol 105:844-8. 2010
    Experimental and clinical trial data have suggested an association between fish oil intake and atrial fibrillation (AF). However, previous observational studies have reported conflicting results regarding this association...
  75. doi Omega-3 fatty acid supplementation does not reduce risk of atrial fibrillation after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial
    Palaniappan Saravanan
    University of Manchester, Manchester, United Kingdom
    Circ Arrhythm Electrophysiol 3:46-53. 2010
    ..Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been reported to reduce the risk of sudden cardiac death presumed to be due to fatal ventricular arrhythmias, but their effect on atrial arrhythmias is unclear...
  76. doi MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation
    Yanjie Lu
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, PR China
    Circulation 122:2378-87. 2010
    A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca(2+) current and shortening of the action potential duration...
  77. ncbi Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study
    A S Go
    Kaiser Permanente Medical Care Program Northern California, Oakland 94611 5714, USA
    Ann Intern Med 131:927-34. 1999
    Warfarin dramatically reduces the risk for ischemic stroke in nonvalvular atrial fibrillation, but its use among ambulatory patients with atrial fibrillation has not been widely studied.
  78. ncbi Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation Investigators
    R G Hart
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284, USA
    J Am Coll Cardiol 35:183-7. 2000
    This study was performed to characterize the risk of stroke in elderly patients with recurrent intermittent atrial fibrillation (AF).
  79. doi Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran
    Michael D Ezekowitz
    Lankenau Institute for Medical Research and The Heart Center, Wynnewood, PA, USA
    Am Heart J 157:805-10, 810.e1-2. 2009
    Vitamin K antagonists (VKAs) are effective for stroke prevention in patients with atrial fibrillation (AF) but are difficult to use...
  80. ncbi Rhythm control versus rate control for atrial fibrillation and heart failure
    Denis Roy
    Montreal Heart Institute and the Université de Montréal, Montreal, QC H1T 1C8, Canada
    N Engl J Med 358:2667-77. 2008
    It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation and heart failure...
  81. ncbi Electrical, contractile and structural remodeling during atrial fibrillation
    Maurits Allessie
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Cardiovasc Res 54:230-46. 2002
    The natural history of atrial fibrillation (AF) is characterized by a gradual worsening with time...
  82. ncbi Worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation
    Riccardo Cappato
    Arrhythmia and Electrophysiology Center, Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
    Circulation 111:1100-5. 2005
    The purpose of this study was to conduct a worldwide survey investigating the methods, efficacy, and safety of catheter ablation (CA) of atrial fibrillation (AF).
  83. doi Left atrial appendage closure with Amplatzer cardiac plug in atrial fibrillation: initial European experience
    Jai Wun Park
    Department of Cardiology, Asklepios Klinik Harburg, Hamburg, Germany
    Catheter Cardiovasc Interv 77:700-6. 2011
    In most patients with atrial fibrillation (AF) and stroke, there is thrombotic embolization from the left atrial appendage (LAA)...
  84. doi Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 159:331-9. 2010
    b>Atrial fibrillation (AF) is associated with increased risk of stroke that can be attenuated with vitamin K antagonists (VKAs)...
  85. ncbi Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation
    Elaine M Hylek
    General Medicine Division, Clinical Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    N Engl J Med 349:1019-26. 2003
    The incidence of stroke in patients with atrial fibrillation is greatly reduced by oral anticoagulation, with the full effect seen at international normalized ratio (INR) values of 2.0 or greater...
  86. ncbi Outcomes of long-standing persistent atrial fibrillation ablation: a systematic review
    Anthony G Brooks
    Department of Cardiology, Royal Adelaide Hospital and the Disciplines of Medicine and Physiology, University of Adelaide, Cardiovascular Research Centre, Adelaide, Australia
    Heart Rhythm 7:835-46. 2010
    Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes.
  87. ncbi Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter
    Bramah N Singh
    Cardiology Division, Veterans Affairs Greater Los Angeles Healthcare System and the David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    N Engl J Med 357:987-99. 2007
    Amiodarone is effective in maintaining sinus rhythm in atrial fibrillation but is associated with potentially serious toxic effects...
  88. doi Stroke and thromboembolism in atrial fibrillation: a systematic review of stroke risk factors, risk stratification schema and cost effectiveness data
    Michael Hughes
    National Collaborating Center for Chronic Conditions, Royal College of Physicians, London, UK
    Thromb Haemost 99:295-304. 2008
    The risk of stroke in atrial fibrillation (AF) needs to be assessed in each patient to determine the clinical and cost-effectiveness of thromboprophylaxis, with the aim of appropriate use of antithrombotic therapy...
  89. ncbi A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate
    Koonlawee Nademanee
    Pacific Rim Electrophysiology Research Institute, Inglewood, California 90301, USA
    J Am Coll Cardiol 43:2044-53. 2004
    We sought to test the hypothesis that complex fractionated electrograms (CFAEs) recorded during atrial fibrillation (AF) could be used as target sites for catheter ablation of AF.
  90. pmc Population prevalence, incidence, and predictors of atrial fibrillation in the Renfrew/Paisley study
    S Stewart
    Clinical Research Initiative in Heart Failure, Wolfson Building (Level 3, University of Glasgow, Glasgow G12 8QQ, UK
    Heart 86:516-21. 2001
    OBJECTIVES: Though atrial fibrillation (AF) is an important cause of cardiovascular morbidity, there are few large epidemiological studies of its prevalence, incidence, and risk factors...
  91. ncbi Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis
    Carl van Walraven
    Clinical Epidemiology Unit, Ottawa Health Research Institute, F 6, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 288:2441-8. 2002
    Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events.
  92. ncbi Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation
    M J Mihm
    Division of Pharmacology/College of Pharmacy, Ohio State University, Columbus, Ohio 43210, USA
    Circulation 104:174-80. 2001
    BACKGROUND: Atrial fibrillation (AF) is associated with severe contractile dysfunction and structural and electrophysiological remodeling...
  93. ncbi Postoperative atrial fibrillation and mortality after coronary artery bypass surgery
    Rollo P Villareal
    Section of Cardiology, Self Regional Healthcare, Greenwood, South Carolina 29646, USA
    J Am Coll Cardiol 43:742-8. 2004
    We sought to determine if the occurrence of postoperative atrial fibrillation (AF) affects early or late mortality following coronary artery bypass surgery (CABG).
  94. pmc Cost of an emerging epidemic: an economic analysis of atrial fibrillation in the UK
    S Stewart
    Division of Health Sciences, The University of South Australia, Adelaide, Australia
    Heart 90:286-92. 2004
    To evaluate the cost of atrial fibrillation (AF) to health and social services in the UK in 1995 and, based on epidemiological trends, to project this estimate to 2000...
  95. ncbi Risk factors associated with atrial fibrillation after noncardiac thoracic surgery: analysis of 2588 patients
    Ara A Vaporciyan
    Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 445, Houston, TX 77030, USA
    J Thorac Cardiovasc Surg 127:779-86. 2004
    The purpose of this study was to identify risk factors associated with the onset of atrial fibrillation after thoracic surgery to allow more targeted interventions in patients with the highest risk.
  96. doi Ganglionated plexi ablation for longstanding persistent atrial fibrillation
    Evgeny Pokushalov
    Arrhythmia Department, State Research Institute of Circulation Pathology, Novosibirsk, Russia
    Europace 12:342-6. 2010
    To study the potential efficacy of ganglionated plexi (GP) ablation in the setting of longstanding persistent atrial fibrillation (AF).
  97. doi Bisphosphonates and atrial fibrillation: systematic review and meta-analysis
    Yoon Kong Loke
    School of Medicine, University of East Anglia, Norwich, UK
    Drug Saf 32:219-28. 2009
    Bisphosphonates are widely used in osteoporosis, but there have been concerns about a potential link between bisphosphonate therapy and atrial fibrillation.
  98. ncbi Long-term outcome after successful catheter ablation of atrial fibrillation
    Wendy S Tzou
    Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Circ Arrhythm Electrophysiol 3:237-42. 2010
    Pulmonary vein isolation (PVI) is increasingly used for treatment of atrial fibrillation (AF), but few reports exist regarding long-term success...
  99. pmc Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation
    Hiroshi Watanabe
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
    Circ Arrhythm Electrophysiol 2:268-75. 2009
    We and others have reported mutations in the cardiac predominant sodium channel gene SCN5A in patients with atrial fibrillation (AF)...
  100. pmc Independent susceptibility markers for atrial fibrillation on chromosome 4q25
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02114, USA
    Circulation 122:976-84. 2010
    Genetic variants on chromosome 4q25 are associated with atrial fibrillation (AF). We sought to determine whether there is more than 1 susceptibility signal at this locus.

Research Grants128 found, 100 shown here

  1. A randomized trial of interventions to improve warfarin adherence
    Kevin G Volpp; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Warfarin is used by millions of Americans with conditions such as atrial fibrillation and deep venous thrombosis to lower their risk of thromboembolic events (e.g., stroke or pulmonary embolism)...
  2. Improved Targeting and Assessment of Electrophysiology Intervention
    Henry Halperin; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) and ventricular tachycardia (VT) affect millions of patients in the United States. These arrhythmias can be cured with catheter ablation, but the arrhythmias often recur...
  3. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with more than 2 million Americans affected, and is growing exponentially...
  4. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..Such interactions result in the reduction of inward rectifier currents, and lead to the termination of atrial fibrillation (AF) and VF...
  5. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..Such interactions result in the reduction of inward rectifier currents, and lead to the termination of atrial fibrillation (AF) and VF...
  6. Subtype-Specific Small Molecule Chemical Probes for Non-neuronal KCNQ1 Potassium
    Meng Wu; Fiscal Year: 2010
    ..There is increasing evidence for their causality for long QT syndrome, familial atrial fibrillation, Jervell and Lange-Nielsen syndrome, Romano-Ward syndrome, short QT syndrome, and sudden infant death ..
  7. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  8. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2010
    ..to SERCA ratio will affect atrial function and predispose the atria to develop atrial pathology including atrial fibrillation upon increased load or stress...
  9. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    b>Atrial fibrillation (AF) is the most common arrhythmia affecting over 2 million Americans, and is associated with an increased risk of stroke, dementia, heart failure and death...
  10. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  11. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  12. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    ..by applicant): The large majority of older patients with autoimmune Graves'hyperthyroidism and atrial fibrillation (AF) have coexisting activating autoantibodies (AA) to the beta1-adrenergic (B1AR) and M2 muscarinic ..
  13. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  14. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    b>Atrial fibrillation (AF) is the most common arrhythmia affecting over 2 million Americans, and is associated with an increased risk of stroke, dementia, heart failure and death...
  15. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  16. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with more than 2 million Americans affected, and is growing exponentially...
  17. CaMKII in Sinus Node Physiology and Disease
    Mark E Anderson; Fiscal Year: 2010
    ..Furthermore, SAN failure is a frequent finding in patients with atrial fibrillation and is associated with increased mortality in heart failure...
  18. NMR Structural Analysis of Calcium Regulation in Muscle
    Gianluigi Veglia; Fiscal Year: 2010
    ..Also, down regulation of SLN mRNA expression has been correlated with atrial fibrillation-induced atrial remodeling...
  19. Angiotensin converting enzyme, angiotensin II, and arrhythmia
    Samuel C Dudley; Fiscal Year: 2010
    ..This application presents a novel hypothesis about why RAS activation causes arrhythmias, contributing to atrial fibrillation (AF) and heart failure (HF)-associated sudden death.
  20. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    Emelia Benjamin; Fiscal Year: 2009
    ..b>Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, affecting more than 2 million ..
  21. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    EMELIA J contact BENJAMIN; Fiscal Year: 2010
    ..b>Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, affecting more than 2 million ..
  22. The Race-Specific Prevalence of Atrial Fibrillation Measured by 48-Hour Holter
    LAURA L LOEHR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide and it is a known risk factor for stroke...
  23. Identification of common genetic variants for atrial fibrillation and PR interval
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    b>Atrial fibrillation (AF) increases the risk of stroke, heart failure, dementia and death. The prevalence of AF doubles for each advancing decade of life and multiple data sources suggest that the prevalence of AF is increasing over time...
  24. HCMR Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
    Stefan Neubauer; Fiscal Year: 2013
    ..Secondary endpoints include all- cause mortality, ventricular tachyarrhythmias, hospitalization for heart failure, atrial fibrillation, and stroke.
  25. Minimally Invasive Surgical Pulmonary Vein Insolation vs. Medical Management in P
    MICHAEL FARRIS WATERS; Fiscal Year: 2010
    ..Broad challenge area (05) Comparative Effectiveness Research and specific Challenge 05-HL-101* Treatment of Atrial Fibrillation. Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting over 2...
  26. Minimally Invasive Surgical Pulmonary Vein Insolation vs. Medical Management in P
    Thomas Beaver; Fiscal Year: 2009
    ..Broad challenge area (05) Comparative Effectiveness Research and specific Challenge 05-HL-101* Treatment of Atrial Fibrillation. Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting over 2...
  27. Development of Novel Approaches for the Pharmacologic Treatment of Atrial Fibrill
    Charles Antzelevitch; Fiscal Year: 2011
    ..assess how these distinctions contribute to atrial-selective sodium channel inhibition and suppression of atrial fibrillation by INa blockers;2) determine to what extent the electrical and pharmacologic heterogeneities uncovered in ..
  28. Role of ankyrin-B in human arrhythmia
    Peter J Mohler; Fiscal Year: 2013
    ..Phenotypes may include sinus node dysfunction, atrial fibrillation (AF), conduction defects, catecholamine-induced polymorphic ventricular arrhythmia, and/or sudden cardiac ..
  29. Atrial Fibrillation: Bridging genetic discovery and clinical associations
    Steven A Lubitz; Fiscal Year: 2013
    ..Over the last four years the candidate has studied the epidemiology and genetics of atrial fibrillation (AF), achieved a Master of Public Health degree, completed cardiac electrophysiology training, and ..
  30. Cyclic nucleotide permeability of connexin mutants related to genetic disease
    Virginijus Valiunas; Fiscal Year: 2013
    ..In another case, Cx40 mutations have been correlated with atrial fibrillation and other arrhythmias...
  31. Identification of a Stretch-Activated Channel with a Role in Cardiac Development
    Dipayan Chaudhuri; Fiscal Year: 2013
    ..For example, inhibitors of these currents are effective against atrial fibrillation in animal models, but designing high-affinty drugs will depend on isolating the channels themselves...
  32. JNK Suppression of Connexin43 Enhances Atrial Fibrillation in Aged Atria
    Xun Ai; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common arrhythmia and causes an increased risk of mortality and significant morbidity (such as stroke and heart failure (HF))...
  33. Improved Targeting and Assessment of Electrophysiology Intervention
    Henry R Halperin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) and ventricular tachycardia (VT) affect millions of patients in the United States. These arrhythmias can be cured with catheter ablation, but the arrhythmias often recur...
  34. Comparative effectiveness of catheter ablation vs medical therapy for atrial fibr
    James Freeman; Fiscal Year: 2013
    ..PROJECT DESCRIPTION Atrial fibrillation (AF) affects over 2...
  35. Structural and Signaling Roles for Cardiac Ankyrin-B
    SHANE CUNHA; Fiscal Year: 2013
    ..to as "ankyrin-B syndrome" and include catecholamine polymorphic ventricular tachycardia, sinus arrhythmia, atrial fibrillation, and delayed conduction/conduction block...
  36. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2010
    ..second aim, we will examine the relationship between persistent subclinical hyperthyroidism and incident atrial fibrillation, hip fracture, and dementia, and in our third aim, we will examine the relationship between persistent ..
  37. CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial Fibrillation
    Xander H T Wehrens; Fiscal Year: 2010
    ..ventricular tachycardia (CPVT), but may also provide an arrhythmogenic trigger in acquired arrhythmias like atrial fibrillation (AF)...
  38. CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial Fibrillation
    XANDER WEHRENS; Fiscal Year: 2009
    ..ventricular tachycardia (CPVT), but may also provide an arrhythmogenic trigger in acquired arrhythmias like atrial fibrillation (AF)...
  39. CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial Fibrillation
    XANDER WEHRENS; Fiscal Year: 2009
    ..ventricular tachycardia (CPVT), but may also provide an arrhythmogenic trigger in acquired arrhythmias like atrial fibrillation (AF)...
  40. CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial Fibrillation
    Xander H T Wehrens; Fiscal Year: 2011
    ..ventricular tachycardia (CPVT), but may also provide an arrhythmogenic trigger in acquired arrhythmias like atrial fibrillation (AF)...
  41. CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial Fibrillation
    Xander H T Wehrens; Fiscal Year: 2010
    ..ventricular tachycardia (CPVT), but may also provide an arrhythmogenic trigger in acquired arrhythmias like atrial fibrillation (AF)...
  42. Genomics of Cardiac Electrical Activity and Arrhythmia
    Nona Sotoodehnia; Fiscal Year: 2013
    ..in cardiac conduction and repolarization can lead to cardiac arrhythmias and adverse outcomes (atrial fibrillation and sudden cardiac death) and can necessitate the placement of cardiac pacemakers and / or defibrillators...
  43. Effect of Statins and Modifiable Factors on Stroke Outcome in Atrial Fibrillation
    Elaine Hylek; Fiscal Year: 2010
    ..S. Cardioembolic strokes resulting from atrial fibrillation (AF) are particularly devastating, with a 30-day mortality of 25%...
  44. ATRIAL FIBRILLATION FOLLOW UP OF RHYTHM MANAGEMENT (AFFIRM)
    EDWARD PRITCHETT; Fiscal Year: 2000
    b>Atrial Fibrillation is the most common disorder of the heart of the heart rhythm requiring medical treatment in the US...
  45. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  46. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan Kadish; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  47. Rapid High-Resolution Electroanatomical Cardiac Mapping System for the Treatment
    DORON HARLEV; Fiscal Year: 2009
    ..b>Atrial fibrillation alone has reached epidemic proportions, estimated to currently afflict ~2.3 million Americans and ~5...
  48. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    Patrick Ellinor; Fiscal Year: 2009
    b>Atrial fibrillation (AF) is the most common arrhythmia affecting over 2 million Americans, and is associated with an increased risk of stroke, dementia, heart failure and death...
  49. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2006
    ..to assess drug-gene interactions on the outcomes of myocardial infarction (MI), stroke, and new-onset atrial fibrillation (AF). The 3 case groups share a single population-based control group...
  50. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2004
    ..to assess drug-gene interactions on the outcomes of myocardial infarction (MI), stroke, and new-onset atrial fibrillation (AF). The 3 case groups share a single population-based control group...
  51. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2005
    ..to assess drug-gene interactions on the outcomes of myocardial infarction (MI), stroke, and new-onset atrial fibrillation (AF). The 3 case groups share a single population-based control group...
  52. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2003
    ..to assess drug-gene interactions on the outcomes of myocardial infarction (MI), stroke, and new-onset atrial fibrillation (AF). The 3 case groups share a single population-based control group...
  53. Novel 3D Catheter Tracking System for Intracardiac Navigation
    DORON HARLEV; Fiscal Year: 2009
    ..b>Atrial fibrillation alone has reached epidemic proportions, estimated to currently afflict ~2.3 million Americans and ~5...
  54. MECHANISM AND BEHAVIOR OF SYMPTOMATIC TACHYCARDIA
    EDWARD PRITCHETT; Fiscal Year: 1999
    ..Duke University Medical Center have used the Rankin General Clinical Research Center to study patients with atrial fibrillation and other common disorders of the heart rhythm...
  55. SURGICAL TREATMENT OF CARDIAC ARRHYTHMIAS
    James Cox; Fiscal Year: 1993
    The most common of all arrhythmias, atrial fibrillation, is associated with approximately 150,000 strokes per year in the United States alone and yet there is presently no medical or surgical therapy capable of consistently curing this ..
  56. SURGICAL TREATMENT OF CARDIAC ARRHYTHMIAS
    James Cox; Fiscal Year: 1992
    The most common of all arrhythmias, atrial fibrillation, is associated with approximately 150,000 strokes per year in the United States alone and yet there is presently no medical or surgical therapy capable of consistently curing this ..
  57. SURGICAL TREATMENT OF CARDIAC ARRHYTHMIAS
    James Cox; Fiscal Year: 1991
    The most common of all arrhythmias, atrial fibrillation, is associated with approximately 150,000 strokes per year in the United States alone and yet there is presently no medical or surgical therapy capable of consistently curing this ..
  58. MECHANISM AND BEHAVIOR OF SYMPTOMATIC TACHYCARDIA
    EDWARD PRITCHETT; Fiscal Year: 2001
    ..Duke University Medical Center have used the Rankin General Clinical Research Center to study patients with atrial fibrillation and other common disorders of the heart rhythm...
  59. Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
    Alan Go; Fiscal Year: 2009
    ..RC2) and specifically responds to the NHLBI RC2 topic of Comparative Effectiveness among adults with atrial fibrillation. Atrial fibrillation is the most common clinically significant arrhythmia in adults and one of the most ..
  60. Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
    DANIEL EDWIN SINGER; Fiscal Year: 2010
    ..RC2) and specifically responds to the NHLBI RC2 topic of Comparative Effectiveness among adults with atrial fibrillation. Atrial fibrillation is the most common clinically significant arrhythmia in adults and one of the most ..
  61. Vein of Marshall as a therapeutic agent in the treatment of atrial fibrillation
    Miguel Valderrabano; Fiscal Year: 2010
    ..is to explore the potential role of ethanol infusion in the vein of Marshall (VOM) in the treatment of atrial fibrillation (AF). AF is the most common sustained rhythm disorder in adults, affects more than 2...
  62. ELECTRODE DESIGN FOR CARDIAC TACHYARRYTHMIA RF ABLATION
    John Webster; Fiscal Year: 2001
    ..Adapted from Applicant's Abstract): The goal of this study is to optimize catheter design for the cure of atrial fibrillation and ventricular tachycardia by endocardial radiofrequency (RF) ablation...
  63. ELECTRODE DESIGN FOR CARDIAC TACHYARRYTHMIA RF ABLATION
    John Webster; Fiscal Year: 2002
    ..Adapted from Applicant's Abstract): The goal of this study is to optimize catheter design for the cure of atrial fibrillation and ventricular tachycardia by endocardial radiofrequency (RF) ablation...
  64. ELECTRODE DESIGN FOR CARDIAC TACHYARRYTHMIA RF ABLATION
    John Webster; Fiscal Year: 2000
    ..Adapted from Applicant's Abstract): The goal of this study is to optimize catheter design for the cure of atrial fibrillation and ventricular tachycardia by endocardial radiofrequency (RF) ablation...
  65. A randomized trial of interventions to improve warfarin adherence
    Stephen Kimmel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Warfarin is used by millions of Americans with conditions such as atrial fibrillation and deep venous thrombosis to lower their risk of thromboembolic events (e.g., stroke or pulmonary embolism)...
  66. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2007
    b>Atrial fibrillation is the most prevalent sustained cardiac arrhythmia, affecting over 2 million Americans...
  67. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2005
    b>Atrial fibrillation is the most prevalent sustained cardiac arrhythmia, affecting over 2 million Americans...
  68. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    b>Atrial fibrillation is the most prevalent sustained cardiac arrhythmia, affecting over 2 million Americans...
  69. Linking redox chemistry and mitochondria in atrium to post-operative arrhythmia
    ETHAN JOHN ANDERSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Post-operative atrial fibrillation (POAF) in patients following cardiac revascularization surgery is a significant health care burden and estimates of occurrence range from 15-65%...
  70. A multiethnic comparative effectiveness study for diagnosis of cardiogenic stroke
    Jeffrey R Gulcher; Fiscal Year: 2010
    ..b>Atrial fibrillation (AF) is known to be a major cause of stroke involved in at least 20% of all ischemic strokes (cardiogenic ..
  71. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2006
    b>Atrial fibrillation is the most prevalent sustained cardiac arrhythmia, affecting over 2 million Americans...
  72. CLOSED-LOOP IMPLANTABLE ANTIARRHYTHMIC DRUG INFUSION
    Robert Arzbaecher; Fiscal Year: 1993
    ..In the previous project period, we developed a system which detects atrial fibrillation and delivers a pharmacokinetically-based infusion of procainamide or disopyramide...
  73. CLOSED-LOOP IMPLANTABLE ANTIARRHYTHMIC DRUG INFUSION
    Robert Arzbaecher; Fiscal Year: 1990
    ..In the previous project period, we developed a system which detects atrial fibrillation and delivers a pharmacokinetically-based infusion of procainamide or disopyramide...
  74. Mechanical stretch and fibrillation dynamics in the left atrium
    Jerome Kalifa; Fiscal Year: 2009
    b>Atrial fibrillation (AF) is the most common arrhythmia in adults and is associated with atrial dilatation which may be acute or chronic...
  75. Mechanical stretch and fibrillation dynamics in the left atrium
    Jerome Kalifa; Fiscal Year: 2007
    b>Atrial fibrillation (AF) is the most common arrhythmia in adults and is associated with atrial dilatation which may be acute or chronic...
  76. Factors Associated with Warfarin Use in Dialysis Patients w/ Atrial Fibrillation
    JAMES BACON WETMORE; Fiscal Year: 2010
    ..Chronic atrial fibrillation (AF), common in the dialysis population, is a potentially-modifiable stroke risk factor...
  77. Real-time MRI-guided RF Ablation of Cardiac TachyArrhythmias
    Orhan Unal; Fiscal Year: 2007
    b>Atrial fibrillation (AF) is the most common adult cardiac tachyarrhythmia affecting more than 2,200,000 people in the US. AF also accounts for 15% of all strokes...
  78. DIASTOLIC MECHANICS OF THE LEFT VENTRICLE AND LEFT ATRIU
    SERJAN NIKOLIC; Fiscal Year: 1992
    ..normal physiological variations, as well as during acute interventions: myocardial stunning and ischemia, atrial fibrillation, mitral stenosis and mitral regurgitation...