arrhythmia

Summary

Summary: Any variation from the normal rhythm or rate of the heart beat.

Top Publications

  1. ncbi hERG potassium channels and cardiac arrhythmia
    Michael C Sanguinetti
    Department of Physiology, University of Utah, 95 South 2000 East, Salt Lake City, Utah 84112, USA
    Nature 440:463-9. 2006
  2. ncbi Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    Igor Splawski
    Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 119:19-31. 2004
  3. pmc Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia
    Razi Khan
    McGill University, Faculty of Medicine, Montreal, Quebec, Canada
    Immunology 118:10-24. 2006
  4. pmc Ionic current basis of electrocardiographic waveforms: a model study
    Kazutaka Gima
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Circ Res 90:889-96. 2002
  5. ncbi Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients
    M T Jorge
    Departamento de Clinica Medica, Universidade Federal de Uberlandia, Av Pará, 1720, Campus Umuarama, 38405 320, Uberlandia, MG, Brazil
    Ann Trop Med Parasitol 97:139-48. 2003
  6. ncbi Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins
    Eugene Patterson
    University of Oklahoma Health Sciences Center and the DVA Medical Center, Oklahoma City, Oklahoma, USA
    J Am Coll Cardiol 47:1196-206. 2006
  7. ncbi Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs
    Bengt R Danielsson
    Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, S 751 24 Uppsala, Sweden
    Reprod Toxicol 24:42-56. 2007
  8. ncbi Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels
    Guiscard Seebohm
    Department of Physiology and Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Circ Res 93:941-7. 2003
  9. ncbi Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes
    L S Meadows
    Department of Pharmacology, The University of Michigan, 1301 MSRB III, Box 0632, 1150 W Medical Center Dr Ann Arbor, MI 48109 0632, United States
    Cardiovasc Res 67:448-58. 2005
  10. pmc Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death
    Hong D Xiao
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 165:1019-32. 2004

Detail Information

Publications248 found, 100 shown here

  1. ncbi hERG potassium channels and cardiac arrhythmia
    Michael C Sanguinetti
    Department of Physiology, University of Utah, 95 South 2000 East, Salt Lake City, Utah 84112, USA
    Nature 440:463-9. 2006
    ..b>Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs...
  2. ncbi Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    Igor Splawski
    Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 119:19-31. 2004
    ..In the heart, prolonged Ca(2+) current delays cardiomyocyte repolarization and increases risk of arrhythmia, the ultimate cause of death in this disorder. These discoveries establish the importance of Ca(V)1...
  3. pmc Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia
    Razi Khan
    McGill University, Faculty of Medicine, Montreal, Quebec, Canada
    Immunology 118:10-24. 2006
    ..fact, the pathogenic effects of TGF-beta1 have now been suggested to play a major role in valvular disease and arrhythmia, particularly atrial fibrillation...
  4. pmc Ionic current basis of electrocardiographic waveforms: a model study
    Kazutaka Gima
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Circ Res 90:889-96. 2002
    ..Given recent advances in understanding the molecular mechanisms of arrhythmia, it is important to relate these electrocardiographic waveforms to cellular electrophysiological processes...
  5. ncbi Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients
    M T Jorge
    Departamento de Clinica Medica, Universidade Federal de Uberlandia, Av Pará, 1720, Campus Umuarama, 38405 320, Uberlandia, MG, Brazil
    Ann Trop Med Parasitol 97:139-48. 2003
    ..of each type of arrythmia were investigated, by age and sex, among 3056 Brazilian patients with cardiac arrhythmia. Each patient investigated had been tested serologically for American trypanosomiasis and 1013 had been found ..
  6. ncbi Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins
    Eugene Patterson
    University of Oklahoma Health Sciences Center and the DVA Medical Center, Oklahoma City, Oklahoma, USA
    J Am Coll Cardiol 47:1196-206. 2006
    ..hypothesis that an increased or prolonged Ca2+ transient during an abbreviated action potential can give rise to early afterdepolarizations (EADs) and triggered arrhythmia by enhanced forward sodium-calcium (Na-Ca) exchange was examined.
  7. ncbi Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs
    Bengt R Danielsson
    Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, S 751 24 Uppsala, Sweden
    Reprod Toxicol 24:42-56. 2007
    ..Mechanistic studies show that the malformations are preceded by embryonic cardiac arrhythmia and periods of hypoxia/reoxygenation in embryonic tissues...
  8. ncbi Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels
    Guiscard Seebohm
    Department of Physiology and Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Circ Res 93:941-7. 2003
    ..and cause long-QT syndrome, a disorder of ventricular repolarization that predisposes affected individuals to arrhythmia and sudden death. Current therapy for long-QT syndrome is inadequate...
  9. ncbi Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes
    L S Meadows
    Department of Pharmacology, The University of Michigan, 1301 MSRB III, Box 0632, 1150 W Medical Center Dr Ann Arbor, MI 48109 0632, United States
    Cardiovasc Res 67:448-58. 2005
    ....
  10. pmc Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death
    Hong D Xiao
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 165:1019-32. 2004
    ..In conclusion, increased local production of angiotensin II in the heart is not sufficient to induce ventricular hypertrophy or fibrosis. Instead, it leads to atrial morphological changes, cardiac arrhythmia, and sudden death.
  11. ncbi Cholinergic stimulation with pyridostigmine reduces ventricular arrhythmia and enhances heart rate variability in heart failure
    Alice Behling
    Division of Cardiology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    Am Heart J 146:494-500. 2003
    Increased ventricular arrhythmia density and reduced heart rate variability are associated with risk of death in patients with heart failure...
  12. pmc Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations
    Igor Splawski
    Howard Hughes Medical Institute, Department of Cardiology, and Genomics Program and Division of Genetics, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:8089-96; discussion 8086-8. 2005
    ..showed prolongation of cardiomyocyte action potentials and delayed afterdepolarizations, factors that increase risk of arrhythmia. These data indicate that gain-of-function mutations of CaV1.2 exons 8 and 8A cause distinct forms of TS.
  13. ncbi Intracellular sodium increase and susceptibility to ischaemia in hearts from type 2 diabetic db/db mice
    R Anzawa
    UMR CNRS 8078, Universite Paris Sud XI, Hopital Marie Lannelongue, 133 avenue de la Resistance, 92350 Le Plessis Robinson, France
    Diabetologia 49:598-606. 2006
    ....
  14. ncbi Liver transplantation does not prevent the development of life-threatening arrhythmia in familial amyloidotic polyneuropathy, Portuguese-type (ATTR Val30Met) patients
    Rolf Hörnsten
    Department of Surgical and Perioperative Sciences, Clinical Physiology, Umea University, Umea, Sweden
    Transplantation 78:112-6. 2004
    ..Because heart arrhythmia and conduction disturbances are well-known manifestations of FAP, the aim of this study was to investigate the ..
  15. ncbi Prevalence, predictors, and mortality significance of the causative arrhythmia in patients with electrical storm
    Atul Verma
    Cleveland Clinic Foundation, Section of Pacing and Electrophysiology, Cleveland, Ohio 44195, USA
    J Cardiovasc Electrophysiol 15:1265-70. 2004
    ..However, little is known about the prevalence, predictors, and mortality implications of the causative arrhythmia in ES...
  16. ncbi Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Marburg, Germany
    Herz 29:673-85. 2004
    ..With documented coronary heart disease, it was advised to consume approximately 1 g/day of EPA+DHA...
  17. pmc Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    BMJ 325:1070. 2002
    To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls.
  18. pmc Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction
    Andre Schmidt
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:2006-14. 2007
    ....
  19. ncbi Effect of action potential duration and conduction velocity restitution and their spatial dispersion on alternans and the stability of arrhythmias
    Isabelle Banville
    Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Cardiovasc Electrophysiol 13:1141-9. 2002
    The slope of the action potential duration (APD) restitution curve has been used to explain wavebreaks during arrhythmia initiation and maintenance. This hypothesis remains incomplete to fully describe the experimental data...
  20. ncbi Ischemia-induced arrhythmia: the role of connexins, gap junctions, and attendant changes in impulse propagation
    Wayne E Cascio
    Division of Cardiology, Department of Medicine, The Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA
    J Electrocardiol 38:55-9. 2005
    ..In large animal hearts, regional ischemia induces two phases of ventricular arrhythmia. The first phase (1A) occurs between 5 and 7 min after arrest of perfusion...
  21. ncbi Mapping epicardial fat with multi-detector computed tomography to facilitate percutaneous transepicardial arrhythmia ablation
    Suhny Abbara
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Eur J Radiol 57:417-22. 2006
    ..MDCT is a reliable modality for visualizing epicardial fat, and should be considered prior to undergoing procedures that are affected by epicardial fat content, especially in elderly and female populations...
  22. pmc Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia
    Jennifer K Mann
    Department of Epidemiology, University of California, Berkeley, 94720, USA
    Environ Health Perspect 110:1247-52. 2002
    ..IHD) hospital admissions were associated with air pollutants in those with and without secondary diagnoses of arrhythmia (ARR) or congestive heart failure (CHF)...
  23. ncbi A 6-month follow-up of intermittent levosimendan administration effect on systolic function, specific activity questionnaire, and arrhythmia in advanced heart failure
    Sophie Mavrogeni
    Onassis Cardiac Surgery Center, Athens, Greece
    J Card Fail 13:556-9. 2007
    ..We administrated LS on a monthly intermittent 24-hour protocol and evaluated the clinical effect after 6 months in a randomized, open, prospective study...
  24. ncbi Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart
    Kiyoko Hattori
    Department of Pediatrics, Graduate School of Medical Science, Kumamoto University, Japan
    Mol Genet Metab 91:285-93. 2007
    ..5-cre mice for heart specific overexpression. The overexpression of calreticulin was associated with arrhythmia, chamber dilation and sudden death, as observed in 6- to 10-week-old mice...
  25. ncbi Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation
    M Roselle Abraham
    Institute of Molecular Cardiobiology, Johns Hopkins University, Carnegie 568, 600 N Wolfe St, Baltimore, MD 21205, USA
    Circ Res 97:159-67. 2005
    ....
  26. ncbi Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?
    Aida Salameh
    Clinic I for Internal Medicine, Department of Cardiology, University of Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Biochim Biophys Acta 1719:36-58. 2005
    ..Disturbances of GJIC in the heart can cause arrhythmia, while in brain electrical activity during seizures seems to be propagated via gap junction channels...
  27. ncbi Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability
    Todd Wisialowski
    Pfizer Global Research and Development, Eastern Point Rd, Building 274, Groton, CT 06340, USA
    J Pharmacol Exp Ther 318:352-9. 2006
    ..varying degrees of cardiovascular liability associated with QT prolongation that can lead to the ventricular arrhythmia torsade de pointes...
  28. ncbi Psychotropic drugs, cardiac arrhythmia, and sudden death
    Harry J Witchel
    Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Clin Psychopharmacol 23:58-77. 2003
    ..the central nervous system are associated with cardiac side effects, some of which are linked with reports of arrhythmia and sudden death...
  29. ncbi Computational tools for modeling electrical activity in cardiac tissue
    Edward J Vigmond
    Department of Electrical and Computer Engineering, University of Calgary, Alberta, Canada
    J Electrocardiol 36:69-74. 2003
    ..Performance results are given for a large-scale simulation which utilized a comprehensive membrane ionic current description...
  30. ncbi Autonomic tone in patients with supraventricular arrhythmia associated with mitral valve prolapse in young men
    Larissa Terechtchenko
    Tyumen Medical Academy, Department of Cardiology, 34 Volodarsky Street, Apart, 33 625000 Tyumen, Russia
    Pacing Clin Electrophysiol 26:444-6. 2003
    ..Frequency domain heart rate variability (HRV) indices were obtained from short-term ECG recordings at rest and during postural stress...
  31. ncbi Arrhythmia risk stratification with regard to prophylactic implantable defibrillator therapy in patients with dilated cardiomyopathy. Results of MACAS, DEFINITE, and SCD-HeFT
    Wolfram Grimm
    Department of Internal Medicine and Cardiology, Hospital of the Philipps University, Marburg, Germany
    Herz 29:348-52. 2004
    ..the Marburg Cardiomyopathy Study (MACAS) revealed left ventricular ejection fraction to be the only significant arrhythmia risk predictor in a relatively large patient population with dilated cardiomyopathy...
  32. ncbi Contribution of tonic vagal modulation of heart rate, central respiratory drive, respiratory depth, and respiratory frequency to respiratory sinus arrhythmia during mental stress and physical exercise
    Jan H Houtveen
    Department of Health Psychology, Utrecht University, The Netherlands
    Psychophysiology 39:427-36. 2002
    This study tested various sources of changes in respiratory sinus arrhythmia (RSA)...
  33. pmc The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia
    Constanze R Scherer
    Aventis Pharma Deutschland GmbH, Cardiovascular Diseases, 65926 Frankfurt am Main, Germany
    Br J Pharmacol 137:892-900. 2002
    ..6. Our results strongly indicate that QT lengthening and cardiac arrhythmia in the reported case of drug-induced LQT are not due to the K897T exchange or to an inhibitory effect of ..
  34. pmc Sex hormones and arrhythmia in myocardial ischemia
    T Korte
    Department of Cardiology, Medical School Hannover, Hannover, Germany
    Br J Pharmacol 149:227-8. 2006
    ..concentration-dependent inhibition of I(CaL) is sufficient to account for the reduction in ischaemia-induced arrhythmia. With this data they have added important information on the influence of sex hormones on cardiac ..
  35. ncbi Role of transtelephonic electrocardiographic monitoring in detecting short-term arrhythmia recurrences after radiofrequency ablation in patients with atrial fibrillation
    Gaetano Senatore
    Divisione di Cardiologia, Ospedale Civile di Cirie TO, Cirie, Italy
    J Am Coll Cardiol 45:873-6. 2005
    ....
  36. ncbi First experience with a Mobile Cardiac Outpatient Telemetry (MCOT) system for the diagnosis and management of cardiac arrhythmia
    Ajay K Joshi
    Lankenau Hospital and Institute for Medical Research Main Line Health Heart Center, Wynnewood, Pennsylvania, USA
    Am J Cardiol 95:878-81. 2005
    ..MCOT does not require activation by the patient. We report data from the first 100 consecutive patients monitored by this new technology...
  37. ncbi SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia
    William P McNair
    University of Colorado Cardiovascular Institute, Denver, Colo, USA
    Circulation 110:2163-7. 2004
    ..family affected by an autosomal dominant cardiac conduction disorder associated with sinus node dysfunction, arrhythmia, and right and occasionally left ventricular dilatation and dysfunction...
  38. ncbi Comparison of autotriggered memory loop recorders versus standard loop recorders versus 24-hour Holter monitors for arrhythmia detection
    James A Reiffel
    Division of Cardiology, Department of Medicine, Columbia University, New York, New York 10032, USA
    Am J Cardiol 95:1055-9. 2005
    ..Further, the higher yield of AT-MLR versus MLR demonstrates the significantly enhanced benefit of autotriggered programmable recording...
  39. ncbi Comparison of noncontact and electroanatomic mapping to identify scar and arrhythmia late after the Fontan procedure
    Dominic J Abrams
    Department of Cardiac Electrophysiology, St Bartholomew s Hospital, London, EC1A 7BE, United Kingdom
    Circulation 115:1738-46. 2007
    The right atrium late after the Fontan procedure is characterized by multiple complex arrhythmia circuits...
  40. ncbi The electrical restitution curve revisited: steep or flat slope--which is better?
    Michael R Franz
    Cardiology Division, Veteran Affairs Medical Center, Washington, DC 20422, USA
    J Cardiovasc Electrophysiol 14:S140-7. 2003
    ..A simple tri-ionic model is suggested that may help explain the shape of the ERC at various repolarization levels and place APD recovery into perspective with intracellular calcium recycling and recovery of contractile force...
  41. ncbi A common human SCN5A polymorphism modifies expression of an arrhythmia causing mutation
    Bin Ye
    Department of Medicine and Physiology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Physiol Genomics 12:187-93. 2003
    ..These results show that the choice of background clone must be carefully considered in mutagenesis studies. This also represents an example of intragenic complementation, the first for such a large protein...
  42. pmc Ventricular arrhythmia, Cheyne-Stokes respiration, and death: observations from patients with defibrillators
    A D Staniforth
    Department of Cardiovascular Medicine, Queens Medical Centre, Nottingham NG7 2UH, UK
    Heart 91:1418-22. 2005
    To determine whether ventricular arrhythmia related to nocturnal hypoxaemia during Cheyne-Stokes respiration (CSR) explains the observation that CSR is an independent marker of death in heart failure.
  43. pmc Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT
    Barry London
    University of Pittsburgh, Cardiovascular Institute, Pittsburgh, PA 15213, USA
    J Physiol 578:115-29. 2007
    Enhanced dispersion of repolarization (DR) and refractoriness may be a unifying mechanism central to arrhythmia genesis in the long QT (LQT) syndrome...
  44. ncbi [Practical attitude toward arrhythmia in the neonate and infant]
    J M Lupoglazoff
    Unité de cardiologie néonatale, Hopital Robert Debre, Paris, France
    Arch Pediatr 11:1268-73. 2004
    ..Congenital atrio-ventricular block is rare but potentially lethal in the first months of life in the absence of permanent pacing. The morbidity remains high during long term follow-up in unpaced children...
  45. ncbi Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
    Faranak Azarbayjani
    Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Uppsala, Sweden
    Epilepsia 43:457-68. 2002
    There is evidence that drug-induced embryonic arrhythmia initiates phenytoin (PHT) teratogenicity...
  46. pmc SIDS: genetic and environmental influences may cause arrhythmia in this silent killer
    Jonathan C Makielski
    Department of Medicine, Cardiovascular Medicine Section and Department of Physiology, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Clin Invest 116:297-9. 2006
    ....
  47. ncbi Prevalence of potential noninvasive arrhythmia risk predictors in healthy, middle-aged persons
    Wolfram Grimm
    Department of Cardiology, Hospital of the Philipps University of Marburg, Marburg, Germany
    Ann Noninvasive Electrocardiol 8:37-46. 2003
    To date, prevalence and clinical significance of noninvasive arrhythmia risk predictors in apparently healthy, middle-aged persons are largely unknown.
  48. ncbi [Cutaneous aplasia, non compaction of the left ventricle and severe cardiac arrhythmia: a new case of MLS syndrome (microphtalmia with linear skin defects)]
    L Kherbaoui-Redouani
    Service de néonatologie et réanimation infantile, American Memorial Hospital, Hôpital d Enfants, 47, rue Cognacq Jay, 52092 cedex, Reims, France
    Arch Pediatr 10:224-6. 2003
    ..The follow-up was complicated by life-threatening cardiac arrhythmia underlying prevention by an early diagnosis and adequate care...
  49. ncbi N-Glycosylation-dependent block is a novel mechanism for drug-induced cardiac arrhythmia
    Ki Ho Park
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Physiology and Biophysics, Piscataway, NJ 08854, USA
    FASEB J 17:2308-9. 2003
    ..We conclude that N-glycosylation may play a key role in the etiology of life-threatening arrhythmia.
  50. ncbi Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia
    Ulrike Langheinrich
    Exelixis Deutschland GmbH, Spemannstrasse 35, D 72076 Tubingen, Germany
    Toxicol Appl Pharmacol 193:370-82. 2003
    ..delayed rectifier K+ channel, HERG (ether-à-go-go-related gene), sometimes leading to life-threatening arrhythmia. In this paper we describe cloning, sequence, and expression of the zebrafish orthologue of HERG, Zerg...
  51. pmc The limited utility of electrocardiography variables used to predict arrhythmia in psychotropic drug overdose
    Nicholas A Buckley
    Department of Clinical Pharmacology, The Canberra Hospital, Australia
    Crit Care 7:R101-7. 2003
    ..The aim of the present study was to examine the relationship between serious arrhythmias in patients with psychotropic drug overdose and electrocardiography (ECG) findings that have been suggested previously to predict this complication...
  52. ncbi Blockade of angiotensin II type 1 receptor improves the arrhythmia morbidity in mice with left ventricular hypertrophy
    Cuntai Zhang
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Circ J 70:335-41. 2006
    ..We examined whether candesartan, an AT1 receptor blocker, has antiarrhythmic effects on mouse model of left ventricular hypertrophy created by transverse aorta constriction (TAC)...
  53. ncbi Teratogenicity by the hERG potassium channel blocking drug almokalant: use of hypoxia marker gives evidence for a hypoxia-related mechanism mediated via embryonic arrhythmia
    Bengt R Danielsson
    Uppsala University, Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala, Sweden
    Toxicol Appl Pharmacol 193:168-76. 2003
    ..These studies show that the embryonic heart reacts with concentration-dependent bradycardia, arrhythmia, and cardiac arrest when exposed to IKr blockers on GDs 10-14...
  54. ncbi [Predictive criteria of early recurrence of atrial arrhythmia after reduction by electrical cardioversion]
    O Paziaud
    Service de cardiologie, Hopital Europeen Georges Pompidou, Paris
    Arch Mal Coeur Vaiss 96:1169-74. 2003
    ..In the "early recurrence" group, the duration of the atrial arrhythmia was longer (p=0.003) and there were fewer treatments with amiodarone (p=0.03)...
  55. ncbi An arrhythmia susceptibility gene in Caenorhabditis elegans
    Ki Ho Park
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Physiology and Biophysics, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:19799-807. 2007
    ..can induce abnormal repolarization by mechanisms that resemble the way KCNE proteins are thought to provoke arrhythmia in human heart...
  56. ncbi Inductionless or limited shock testing is possible in most patients with implantable cardioverter- defibrillators/cardiac resynchronization therapy defibrillators: results of the multicenter ASSURE Study (Arrhythmia Single Shock Defibrillation Threshold T
    John D Day
    Utah Heart Clinic Arrhythmia Service, LDS Hospital, 324 10th Ave, 206, Salt Lake City, UT 84103, USA
    Circulation 115:2382-9. 2007
    ..The ASSURE Study (Arrhythmia Single Shock Defibrillation Threshold Testing Versus Upper Limit of Vulnerability: Risk Reduction Evaluation ..
  57. ncbi Lactose causes heart arrhythmia in the water flea Daphnia pulex
    Anthony K Campbell
    Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Comp Biochem Physiol B Biochem Mol Biol 139:225-34. 2004
    ..Lactose (50-200 mM) inhibited the heart rate by 30-100% (K(1/2)=60 mM) and generated severe arrhythmia within 60 min. These effects were fully reversible by 3-4 h...
  58. pmc Electrophysiological characteristics and outcome in patients with idiopathic right ventricular arrhythmia compared with arrhythmogenic right ventricular dysplasia
    F Niroomand
    Institute of Cardiology, University of Milan, IRCCS, Fondazione I Monzino, Milan, Italy
    Heart 87:41-7. 2002
    ..Arrhythmias caused by right ventricular dysplasia (ARVD) are refractory to treatment and may cause sudden death. It is difficult to distinguish between these two types of arrhythmia.
  59. ncbi Cardiac arrhythmia due to subclavian catheter fracture and embolization
    Jose Nazareno
    University of Western Ontarion, London, Canada
    Can J Cardiol 21:791-2. 2005
    ..The present report discusses a case in which the clinical presentation led to early recognition of catheter fracture and embolization, and the subsequent safe removal of the VAD...
  60. ncbi [Anandamide and R-(+)-methanandamide prevent development of ischemic and reperfusion arrhythmia in rats by stimulation of CB2-receptors]
    A V Krylatov
    Laboratory of Experimental Cardiology, Institute of Cardiology, Kyevskaya 111, 634050 Tomsk, Russia
    Eksp Klin Farmakol 65:6-9. 2002
    ..We therefore conclude that CB2 receptor stimulation increases the heart tolerance to ischemic and reperfusion arrhythmias...
  61. ncbi MRI to assess arrhythmia and cardiomyopathies
    Robson Macedo
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Magn Reson Imaging 24:1197-206. 2006
    ..In this review we discuss the background and potential of this approach, as well as its usefulness for assessing arrhythmias and cardiomyopathies...
  62. ncbi An arrhythmia classification system based on the RR-interval signal
    M G Tsipouras
    Deparment of Computer Science, Unit of Medical Technology and Intelligent Information Systems, University of Ioannina Campus, P O Box 1186, GR 45110 Ioannina, Greece
    Artif Intell Med 33:237-50. 2005
    ..This paper proposes a knowledge-based method for arrhythmic beat classification and arrhythmic episode detection and classification using only the RR-interval signal extracted from ECG recordings...
  63. ncbi Characterization of the relationship between preshock state and virtual electrode polarization-induced propagated graded responses resulting in arrhythmia induction
    David W Bourn
    Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA
    Heart Rhythm 3:583-95. 2006
    ....
  64. ncbi Correction of ionized plasma magnesium during cardiopulmonary bypass reduces the risk of postoperative cardiac arrhythmia
    Nicholas J Wilkes
    Department of Anaesthesia and Cardiothoracic Surgery, Royal Free Hospital, London, United Kingdom
    Anesth Analg 95:828-34, table of contents. 2002
    ..whether the intraoperative measurement and correction of ionized plasma magnesium can reduce the risk of cardiac arrhythmia after cardiopulmonary bypass...
  65. ncbi Implantable dual-chamber defibrillator for the selective treatment of spontaneous atrial and ventricular arrhythmias: arrhythmia incidence and device performance
    Andreas Schuchert
    Department of Cardiology, University of Hamburg, Martinistr 11, 20253 Hamburg, Germany
    J Interv Card Electrophysiol 12:149-56. 2005
    ..The purpose of this prospective study was to evaluate the incidence and termination of spontaneous atrial and ventricular tachyarrythmias in patients with a history of atrial tachyarrhythmias...
  66. ncbi Perioperative and postoperative arrhythmia in three-vessel coronary artery disease patients and antiarrhythmic effects of ischemic preconditioning
    Zhong Kai Wu
    Division of Cardiac Surgery, Department of Surgery, Tampere University Hospital, 33521 Tampere, Finland
    Eur J Cardiothorac Surg 23:578-84. 2003
    Sudden cardiac death caused by arrhythmia remains a major unsolved problem after coronary artery bypass grafting (CABG)...
  67. ncbi Calcium cycling in heart failure: the arrhythmia connection
    Steven M Pogwizd
    Department of Medicine, University of Illinois at Chicago, USA
    J Cardiovasc Electrophysiol 13:88-91. 2002
    ..It is imperative that therapeutic approaches for ventricular tachycardia in HF take into consideration cellular Ca handling and excitation-contractile coupling, and their alteration in the failing heart...
  68. ncbi Comparison of automatic and patient-activated arrhythmia recordings by implantable loop recorders in the evaluation of syncope
    Cengiz Ermis
    The Cardiac Arrhythmia Center, University of Minnesota Medical School, and Veterans Administration Medical Center, Minneapolis, Minnesota, USA
    Am J Cardiol 92:815-9. 2003
    ..The arrhythmia syncope grading system used 5 levels, ranging from grade 0 (rhythm recorded during syncope) to grade IV (rhythm ..
  69. ncbi Comparison of arrhythmia recurrence in patients presenting with ventricular fibrillation versus ventricular tachycardia in the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial
    Merritt H Raitt
    Portland VA Medical Center, Oregon Health and Science University, Portland, Oregon, USA
    Am J Cardiol 91:812-6. 2003
    ..ICD printouts were analyzed both by a committee blinded to the patients' original presenting arrhythmia and by the local investigator. During 31 +/- 14 months of follow-up, 2,673 therapies were reported...
  70. ncbi Hypertension and arrhythmia: blood pressure control and beyond
    A Yildirir
    Cardiology Department, Baskent University, Turkey
    Europace 4:175-82. 2002
    ....
  71. pmc Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia
    Cordula M Wolf
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:18123-8. 2005
    ..In contrast, the amount of ventricular hypertrophy was significantly associated with increased arrhythmia susceptibility...
  72. ncbi Prevalence and clinical significance of cardiac arrhythmia in Anderson-Fabry disease
    Jaymin S Shah
    The Heart Hospital, University College London, London, United Kingdom
    Am J Cardiol 96:842-6. 2005
    ..than 60% of patients with AFD have evidence for cardiac involvement; the prevalence and clinical significance of arrhythmia in AFD are unknown. Seventy-eight consecutive patients (mean age 43.5 +/- 15.0 years, range 13.0 to 83...
  73. ncbi Fatal ventricular arrhythmia as a complication of transesophageal echocardiography
    Sorel Goland
    Heart Institute, Kaplan Medical Center, Rehovot 76100, Israel
    Eur J Echocardiogr 6:151-3. 2005
    To report a case of serious ventricular arrhythmia during transesophageal echocardiography.
  74. ncbi n-3 Fatty acids, cardiac arrhythmia and fatal coronary heart disease
    Ingeborg A Brouwer
    Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Prog Lipid Res 45:357-67. 2006
    n-3 Polyunsaturated fatty acids (n-3 PUFA) are suggested to prevent cardiac death via inhibition of cardiac arrhythmia. In this review we discuss the results of human studies on intake of n-3 PUFAs and heart disease and, more specifically,..
  75. ncbi Gender disparities in cardiac cellular electrophysiology and arrhythmia susceptibility in human failing ventricular myocytes
    Arie O Verkerk
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Heart J 46:1105-18. 2005
    Gender disparities in ECG variables and susceptibility to arrhythmia exist. The basis of these sex-related distinctions in cardiac electrophysiology has been extensively studied in various species, but is virtually unexplored in humans...
  76. ncbi Fatal postoperative arrhythmia in a man with a remote history of methamphetamine and cocaine use: a case report
    David S Inouye
    The John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96822, USA
    Hawaii Med J 63:82-6. 2004
    ....
  77. ncbi A systematic review and meta-analysis of the impact of omega-3 fatty acids on selected arrhythmia outcomes in animal models
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:1557-65. 2005
    ..of the literature on controlled animal studies that assessed the effects of omega-3 fatty acids on selected arrhythmia outcomes...
  78. ncbi Do arrhythmia patients improve survival by participating in randomized clinical trials? Observations from the Cardiac Arrhythmia Suppression Trial (CAST)and the Antiarrhythmics Versus Implantable Defibrillators Trial (AVID)
    Al Hallstrom
    Clinical Trial Center, University of Washington, 1107 NE 45th Street, Suite 405, Seattle, WA 98105 4689, USA
    Control Clin Trials 24:341-52. 2003
    ..We attempt to address this question for participants in the Cardiac Arrhythmia Suppression Trial (CAST) and the Antiarrhythmics Versus Implantable Defibrillators (AVID) studies...
  79. ncbi Subdiaphragmatic murine electrophysiological studies: sequential determination of ventricular refractoriness and arrhythmia induction
    David E Gutstein
    Department of Medicine, Division of Cardiology, New York University School of Medicine, VA Harbor Medical Center, 423 E 23rd Street, 6 West 6005BW, New York, NY 10010, USA
    Am J Physiol Heart Circ Physiol 285:H1091-6. 2003
    ..of the risk of arrhythmias in cardiac patients and provides a powerful tool for understanding the mechanisms of arrhythmia in experimental models...
  80. ncbi Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial
    Bruce L Wilkoff
    The Cleveland Clinic Foundation, 9500 Euclid Ave, Desk F 15, Cleveland, OH 44195, USA
    JAMA 288:3115-23. 2002
    ..Most currently implanted ICD devices provide dual-chamber pacing therapy. The most common comorbid cause for mortality in this population is congestive heart failure...
  81. ncbi Emotional and physical precipitants of ventricular arrhythmia
    Rachel Lampert
    Yale University School of Medicine, New Haven, Conn, USA
    Circulation 106:1800-5. 2002
    ..Whether emotional or physical stressors can trigger spontaneous ventricular arrhythmias in patients at risk has not been systematically evaluated...
  82. ncbi Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials
    Jingjing Zhang
    Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    JAMA 296:1619-32. 2006
    Adverse effects of selective cyclooxygenase 2 (COX-2) inhibitors on renal events and arrhythmia have been controversial, with suggestions of a class effect.
  83. ncbi Preserved postischemic heart function in sucrose-fed type 2 diabetic OLETF rats
    Hong Chen
    Department of Pharmacology, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China
    Life Sci 72:2839-51. 2003
    ..Less norepinephrine release may play a role in preventing postischemic functional deterioration in sucrose-fed diabetic hearts...
  84. ncbi Implantable cardiac arrhythmia devices--Part II: implantable cardioverter defibrillators and implantable loop recorders
    Fred Kusumoto
    Electrophysiology and Pacing Service, Division of Cardiology, Department of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA
    Clin Cardiol 29:237-42. 2006
    ..The implantable loop recorder has become an important diagnostic tool for the patient with unexplained syncope...
  85. ncbi Long-term fish consumption is associated with protection against arrhythmia in healthy persons in a Mediterranean region--the ATTICA study
    Christina Chrysohoou
    First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
    Am J Clin Nutr 85:1385-91. 2007
    ..Dietary habits have long been associated with many manifestations of cardiovascular disease...
  86. ncbi Fatal cardiac arrhythmia after repeated exposure to 1,1-difluoroethane (DFE)
    Joseph Avella
    Department of Forensic Toxicology, Suffolk County Office of the Medical Examiner, Hauppauge, New York 11788, USA
    Am J Forensic Med Pathol 27:58-60. 2006
    ..7 mg/kg, and vitreous fluid 25.1 mg/L. The cause of death was determined to be a fatal cardiac arrhythmia due to intoxication with 1,1-difluoroethane...
  87. ncbi Insular involvement in brain infarction increases risk for cardiac arrhythmia and death
    Halim Abboud
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France
    Ann Neurol 59:691-9. 2006
    ..Brain injuries may induce cardiac dysrhythmias and sudden cardiac death...
  88. ncbi Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy
    Hongmei Ruan
    Department of Anesthesiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Circulation 116:596-605. 2007
    ..However, the underlying signaling mechanisms involved in the induction of arrhythmia and electrophysiological remodeling in cardiac hypertrophy are unclear.
  89. ncbi Electrical and ionic abnormalities in the heart of cardiomyopathic hamsters: in quest of a new paradigm for cardiac failure and lethal arrhythmia
    Aiji Sakamoto
    Division of Biotechnology, National Cardiovascular Center Research Institute, Osaka, Japan
    Mol Cell Biochem 259:183-7. 2004
    Cardiomyopathy is primary degenerative disease of myocardium, which leads to cardiac failure and lethal arrhythmia. An appropriate model animal of a particular disease is, in general, greatly helpful for better understanding of its ..
  90. ncbi Risk of severe cardiac arrhythmia in male utility workers: a nationwide danish cohort study
    Christoffer Johansen
    Institute of Cancer Epidemiology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Am J Epidemiol 156:857-61. 2002
    ..the 50- to 60-Hz frequency band, the authors launched an epidemiologic study of the incidence of severe cardiac arrhythmia, as indicated by the need for a pacemaker, in a nationwide cohort of Danish utility workers...
  91. ncbi Outcomes after late reoperation in patients with repaired tetralogy of Fallot: the impact of arrhythmia and arrhythmia surgery
    Tara Karamlou
    Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 81:1786-93; discussion 1793. 2006
    ..outcomes in patients requiring late reoperation after tetralogy of Fallot (ToF) repair to identify risk factors for arrhythmia and determine whether arrhythmia surgery decreased the risk of subsequent death or recurrent arrhythmia.
  92. ncbi The cardiac ryanodine receptor (calcium release channel): emerging role in heart failure and arrhythmia pathogenesis
    Mark Scoote
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse Street, London, UK
    Cardiovasc Res 56:359-72. 2002
    ..Heart failure and arrhythmia generation are both pathophysiological states that can result from deranged excitation-contraction coupling...
  93. pmc Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia
    Charulatha Ramanathan
    Cardiac Bioelectricity Research and Training Center, and Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Nat Med 10:422-8. 2004
    ....
  94. ncbi Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes
    Peter Milberg
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Pharmacol Exp Ther 303:218-25. 2002
    ..This effect may be related to a rectangular pattern of action potential prolongation, whereas erythromycin and clarithromycin cause triangular action potential prolongation and induce TdP...
  95. ncbi Electromagnetic fields and health effects--epidemiologic studies of cancer, diseases of the central nervous system and arrhythmia-related heart disease
    Christoffer Johansen
    Department of Psychosocial Cancer Research, Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark
    Scand J Work Environ Health 30:1-30. 2004
    ..of the risk of cancer, cause-specific mortality rates, risks for neurodegenerative diseases, and the risk of arrhythmia-related heart disease among employees exposed to extremely low-frequency (50-Hz) electromagnetic fields (EMF) in ..
  96. pmc Exacerbation of acidosis during ischemia and reperfusion arrhythmia in hearts from type 2 Diabetic Otsuka Long-Evans Tokushima Fatty rats
    Ryuko Anzawa
    Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Cardiovasc Diabetol 6:17. 2007
    Sensitivity to ischemia and its underlying mechanisms in type 2 diabetic hearts are still largely unknown. Especially, correlation between reperfusion induced ventricular arrhythmia and changes in intracellular pH has not been elucidated.
  97. ncbi Acute hypoxia differentially regulates K(+) channels. Implications with respect to cardiac arrhythmia
    Livia C Hool
    School of Biomedical and Chemical Sciences Australia and The Western Australian Institute of Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Eur Biophys J 34:369-76. 2005
    ..The implications with respect to effects of hypoxia on the channel and triggering of cardiac arrhythmia will be discussed.
  98. ncbi Cardiac troponin I as a predictor of arrhythmia and ventricular dysfunction in trauma patients with myocardial contusion
    Gunesh P Rajan
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland
    J Trauma 57:801-8; discussion 808. 2004
    ..In this study, the authors determined the strength of the association between cardiac troponin I (cTnI) levels and the risk of arrhythmia or the development of left ventricular dysfunction in a cohort of patients with blunt chest trauma.
  99. ncbi Facioscapulohumeral muscular dystrophy and occurrence of heart arrhythmia
    Carlo Pietro Trevisan
    Department of Neurosciences, University of Padua, Padua, Italy
    Eur Neurol 56:1-5. 2006
    ..Although with heterogeneous results, studies reported to date indicate that heart alterations unrelated to cardiomyopathy are possible in FSHD...
  100. ncbi The beneficial effects of total cavopulmonary conversion and arrhythmia surgery for the failed Fontan
    Constantine Mavroudis
    Divisions of Cardiovascular Thoracic Surgery and Cardiology, Children s Memorial Hospital, Chicago, IL 60614, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 5:12-24. 2002
    ..We present our experience with total cavopulmonary artery conversion and arrhythmia surgery...
  101. pmc Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1 modelling long QT syndrome 5
    Glyn Thomas
    Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    J Physiol 578:99-114. 2007
    ..These findings suggest arrhythmic effects of reduced outward currents expected in KCNE1-/- hearts and their abolition by antagonism of inward L-type Ca2+ current...

Research Grants73

  1. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..Since 2008, I have been a postdoctoral fellow at the University of Michigan (U of M) Center for Arrhythmia Research. I also received an American Heart Association Postdoctoral Fellowship...
  2. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..Since 2008, I have been a postdoctoral fellow at the University of Michigan (U of M) Center for Arrhythmia Research. I also received an American Heart Association Postdoctoral Fellowship...
  3. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..QT interval, the electrical manifestation of repolarization in ventricular myocytes, is a major cause of cardiac arrhythmia and sudden death...
  4. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..QT interval, the electrical manifestation of repolarization in ventricular myocytes, is a major cause of cardiac arrhythmia and sudden death...
  5. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..It has been shown that the hearts of hibernating animals are resistant to cardiac arrhythmia (including VF) induced by many interventions such as hypothermia, Ca-overload, and also ischemia, etc...
  6. Purkinje Origin of Ischemic Ventricular Tachycardia and Fibrillation
    James B Martins; Fiscal Year: 2013
    ..generating cellular calcium based oscillations termed delayed afterdepolarization (DADs) giving rise to an arrhythmia called triggered activity (TA)...
  7. Intravenous Protein Therapy for Myotonic Dystrophy Type 1
    Richard Weisbart; Fiscal Year: 2010
    ..in DM1;including muscle wasting and myotonia, insulin resistance, testicular atrophy, cutaneous tumors cardiac arrhythmia and cognition defects (4- 8)...
  8. Regulation of Cardiac Kv Channel Expression
    Edwin S Levitan; Fiscal Year: 2013
    ..endosome-induced p38 kinase signaling may be a therapeutic target for maintaining cardiac function without arrhythmia during heart failure...
  9. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..including hypertension, abdominal obesity, hyperglycemia, insulin resistance, elevated triglycerides and cardiac arrhythmia. Stress is a common cause of moderately elevated glucocorticoids, and stress is also a risk factor for ..
  10. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2012
    ..myoblasts have demonstrated engraftment and improvement in left ventricular function but with adverse event of arrhythmia. However, cardiomyocyte protection and vessel collateralization of the myocardium is not primarily affected...
  11. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    Bjorn C Knollmann; Fiscal Year: 2012
    ..rate dependence AIM 3: To determine the effect of myofilament Ca2+ sensitization on cell-cell coupling and on arrhythmia susceptibility in the intact heart The results of the proposed experiments will significantly advance our ..
  12. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis J Neufeld; Fiscal Year: 2011
    ..patients, can develop over decades, life-threatening iron-related complications including heart failure, arrhythmia, cirrhosis, diabetes, as well as infertility and other reproductive endocrine disorders...
  13. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    ..Importantly, the incidence of this arrhythmia increases with age, with the result that AF is fast becoming the latest `epidemic'in an aging population...
  14. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
    ..cardiac myocyte lipid content leads to abnormal regulation of ion channels and gap junctions, promoting arrhythmia. Increased cardiac myocyte lipid stores are observed in obese and diabetic patients and this is proposed to ..
  15. Role of Lipoproteins in Chagasic heart disease
    JYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013
    ..heart disease is characterized by myocarditis associated with prominent fibrotic scarring, cardiac hypertrophy, arrhythmia, cardiomyopathy, heart failure and secondary thromboembolism...
  16. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
    ..In addition, we found that SLN levels are significantly altered in diseased atria (heart failure and arrhythmia) of dogs and human, suggesting that an alteration in SLN /SERCA ratio could contribute to altered Ca2+ transport ..
  17. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William A Catterall; Fiscal Year: 2013
    ..Impairment of Na channel function causes periodic paralysis, epilepsy, chronic pain, migraine, and cardiac arrhythmia. Elucidation of the molecular basis for electrical signaling is a major challenge for molecular biology and ..
  18. Role of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitability
    Peter J Mohler; Fiscal Year: 2013
    ..Our recent findings support a new basis for arrhythmia based not on mutations which affect channel biophysics, but instead on mutations to proteins which are required ..
  19. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    ..Importantly, the incidence of this arrhythmia increases with age, with the result that AF is fast becoming the latest `epidemic'in an aging population...
  20. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    Atrial fibrillation (AF) is the most common arrhythmia affecting over 2 million Americans, and is associated with an increased risk of stroke, dementia, heart failure and death...
  21. Neural Actions of Toluene
    John J Woodward; Fiscal Year: 2013
    ..academic performance, brain abnormalities and a sudden-death syndrome resulting from solvent-induced cardiac arrhythmia. Although abused inhalants produce ethanol-like signs of intoxication, their sites and mechanisms of action that ..
  22. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with more than 2 million Americans affected, and is growing exponentially...
  23. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..cause and a consequence of ventricular tachycardia and fibrillation, two potentially lethal forms of cardiac arrhythmia. The goals of this project are to understand the molecular details of Slo2...
  24. Angiotensin converting enzyme, angiotensin II, and arrhythmia
    Samuel C Dudley; Fiscal Year: 2010
    ..This application presents a novel hypothesis about why RAS activation causes arrhythmias, contributing to atrial fibrillation (AF) and heart failure (HF)-associated sudden death. ..
  25. Low energy ventricular defibrillator
    Qun Sha; Fiscal Year: 2012
    ..patients with ICDs may experience inappropriate shocks within three years of implant in response to a non-lethal arrhythmia or electrical noise within the device...
  26. Redox Modification of the Arrhythmic Substrate in Heart Failure
    RAIMOND LESTER WINSLOW; Fiscal Year: 2013
    ..is to examine how enhanced oxidative stress alters the electrophysiology, Ca2+ regulatory processes, and arrhythmia susceptibility of myocytes from failing hearts (pressure-overload model)...
  27. Calcium Handling in Cardiac Pathophysiology
    Evangelia G Kranias; Fiscal Year: 2013
    ..findings will provide new mechanistic insights underlying the role of impaired SR Ca-cycling in heart failure and arrhythmia development and may reveal new molecular pathways and targets associated with cardiomyocyte stress conditions.
  28. Gender Specific Complications of Diabetic Autonomic Neuropathy: A New Mouse Model
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ..DAN has been associated with an increased incidence of arrhythmia and sudden death in diabetics...
  29. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    EMELIA J contact BENJAMIN; Fiscal Year: 2010
    ..Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, affecting more than 2 million individuals in the US, with growing prevalence as the ..
  30. Prenatal diet, PM2.5 and programming of the infant autonomic response
    Rosalind J Wright; Fiscal Year: 2013
    ..An electrophysiological approach is also employed to analyze ANS reactivity [indexed by respiratory sinus arrhythmia (RSA)] in response to the same in-laboratory stressor...
  31. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
    ..Elevated levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy) are associated with cardiac arrhythmia and sudden cardiac death (SCO)...
  32. PARASYMPATHETIC DYSFUNCTION IN OBESITY: EFFECT OF CHOLESTEROL ON VAChT
    Yifan Li; Fiscal Year: 2013
    ..serious public health issue in the United States 1 and worldwide 2 and is a major risk factor for hypertension, arrhythmia, myocardial ischemia, heart failure1, 3-6, and diabetes4, 7...
  33. The Race-Specific Prevalence of Atrial Fibrillation Measured by 48-Hour Holter
    LAURA L LOEHR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide and it is a known risk factor for stroke...
  34. Neurotrophins and Post-infarct Plasicity in Cardiac Sympathetic Neurons
    Beth A Habecker; Fiscal Year: 2013
    ..transmission in the heart, and sympathetic dysfunction is a major contributor to post-infarct ventricular arrhythmia and sudden cardiac death, which kill ~300,000/year in the U.S...
  35. Sex Hormones and Cardiac Arrhythmia in Transgenic LQT2 Rabbits
    Gideon Koren; Fiscal Year: 2012
    ..abstract_text> ..
  36. Titin Splicing Mechanisms and Physical Implications
    Marion L Greaser; Fiscal Year: 2010
    ..In addition the rat mutation model we have developed should help to understand mechanisms of cardiac arrhythmia and sudden death.
  37. Regulation of sympathetic function by infarction
    Beth A Habecker; Fiscal Year: 2013
    ..basis for sympathetic plasticity following cardiac injury, and how neural changes contribute to increased arrhythmia susceptibility...
  38. Minimally Invasive Surgical Pulmonary Vein Insolation vs. Medical Management in P
    MICHAEL FARRIS WATERS; Fiscal Year: 2010
    ..Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting over 2.5 million Americans at a cost of over 7 billion dollars per year to Medicare alone...
  39. Mechanisms of permeation and gating of voltage-sensing domains
    Francesco Tombola; Fiscal Year: 2013
    ..of VSD-containing proteins is associated with numerous diseases, such as epilepsy, periodic paralysis, cardiac arrhythmia, cancer and autoimmune disorders. Some VSDs conduct ions across the membrane under physiological conditions...
  40. Role of ankyrin-B in human arrhythmia
    Peter J Mohler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Defects in cardiac excitability are the basis for human arrhythmia and sudden cardiac death, a leading cause of mortality in developed countries...
  41. Cardiac and Renal Effects of N-Acetylcysteine
    Markus Meyer; Fiscal Year: 2011
    ..and renal apoptosis (TUNEL stain), renal function (Creatinine), renal tubular markers of kidney injury and an arrhythmia evaluation (ECG telemetry, electrophysiological testing)...
  42. Aging, Sex, and Neural Cardiovascular Control During Dynamic Exercise
    Paul J Fadel; Fiscal Year: 2012
    ..because it can increase the occurrence of stroke and adverse cardiac events such as acute myocardial infarction, arrhythmia or cardiac arrest elevating the risk of performing physical activity as well as daily chores...
  43. Cyclic nucleotide permeability of connexin mutants related to genetic disease
    Virginijus Valiunas; Fiscal Year: 2013
    ..for wild-type Cx43 and Cx40 and compare them to human mutations of Cx43 and Cx40 associated with ODDD and arrhythmia. The cyclic nucleotides, cAMP and cGMP are of particular interest as both are important in normal bone ..
  44. Sodium Channels and Cardiac Arrhythmias
    Isabelle Deschenes; Fiscal Year: 2013
    ..Although this work on inheritable channelopathies has greatly contributed to our understanding of arrhythmia mechanisms, monogenic disorders leading to arrhythmias are rare...
  45. Cardiomyocyte stretch and intracellular calcium release with advancing age
    TIMOTHY LEE DOMEIER; Fiscal Year: 2013
    ..is less effective as a pump and operates at elevated filling pressures and volumes with a greater propensity for arrhythmia. Because the mechanism(s) underlying cardiac dysfunction with advancing age are poorly understood, developing ..
  46. Azithromycin and Sudden Cardiac Death: Electrophysiologic Mechanisms
    Katherine T Murray; Fiscal Year: 2013
    ..has been linked to polymorphic ventricular tachycardia in the setting of a normal QT interval in inherited arrhythmia syndromes...
  47. Role of serum- and glucocorticoid-regulated kinase-1 in electrical remodeling
    Anthony Rosenzweig; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adverse cardiac remodeling is a common prelude to heart failure and arrhythmia, but little is known about the signaling mechanisms that mediate this transition...
  48. Atrial Fibrillation: Bridging genetic discovery and clinical associations
    Steven A Lubitz; Fiscal Year: 2013
    ..The aims will inform our understanding of the mechanisms, clinical features, and outcomes of AF, a morbid arrhythmia of substantial public health importance...
  49. Multi-scale Systems Model of Murine Heart Failure
    Andrew D McCulloch; Fiscal Year: 2013
    ..to heart failure, including: (1) crosstalk between 2-adrenergic receptor and CaMKII signaling;(2) triggered arrhythmia susceptibility at the subcellular, cellular, tissue and organ scales;(3) cardiac mechanical dysfunction at cell, ..
  50. Fundamental Biology of SCD and its Application to Identify Patients at Risk
    GORDON FRANK TOMASELLI; Fiscal Year: 2013
    ..firings for ventricular tachycardia (VT) or ventricular fibrillation (VF) and deaths due to ventricular arrhythmia not corrected by the ICD...
  51. Suprachiasmatic Nucleus Output Pathway for Learning and Memory
    H Craig Heller; Fiscal Year: 2013
    ..This arrhythmia results in major memory deficits in object recognition and spatial navigation...
  52. Human Myocardium Engineered Using Developmentally-Inspired Protein Scaffolds
    ADAM WALTER FEINBERG; Fiscal Year: 2012
    ..cardiac-related death in the US and those fortunate to survive the acute event suffer from chronic high risk of arrhythmia, stroke and congestive heart failure...
  53. "Connexin-Dependent Transcriptomic Networks in Controlling the Heart Rhythm"
    DUMITRU ANDREI IACOBAS; Fiscal Year: 2010
    ..genes in this organization, with the long-term goal to open novel therapeutic horizons in the treatment of arrhythmia. PUBLIC HEALTH RELEVANCE: Gap junctions between cardiac muscle cells provide the channels for intercellular ..
  54. Comparative effectiveness of catheter ablation vs medical therapy for atrial fibr
    James Freeman; Fiscal Year: 2013
    ..AF), using radiofrequency energy or cryotherapy to electrically isolate the pulmonary veins and eliminate arrhythmia foci, is a new therapy that is currently used to treat 50,000 patients per year in the United States and 60,000 ..
  55. PREDICTIVE GENES, MECHANISMS, AND CLINICAL BIOMARKERS OF SUDEP
    Jeffrey Noebels; Fiscal Year: 2013
    ..monitoring of individuals with Dravet Syndrome and others at high risk of sudden death (ictal hypoxemia, cardiac arrhythmia)...
  56. Structural and Signaling Roles for Cardiac Ankyrin-B
    SHANE CUNHA; Fiscal Year: 2013
    ..referred to as "ankyrin-B syndrome" and include catecholamine polymorphic ventricular tachycardia, sinus arrhythmia, atrial fibrillation, and delayed conduction/conduction block...
  57. Calsequestrin in Ventricular Arrhythmia and Sudden Death
    Bjorn C Knollmann; Fiscal Year: 2013
    ..myocytes and/or Purkinje cells is a fundamental defect that causes premature SR Ca release and increases arrhythmia susceptibility. This is applicable to inherited syndromes (e.g...
  58. A Total Synthesis of Gambierol Using an Epoxide-Opening Cascade Approach
    DENISE ANN COLBY; Fiscal Year: 2010
    ..Kv channel blockers are potential therapeutic agents in the treatment of arrhythmia, diseases of the central nervous system, and as immunosuppressants...
  59. Induced Pluripotent Stem Cells for the Study of Long QT Syndrome
    ERIC DAVID ADLER; Fiscal Year: 2013
    ..syndrome is a cardiovascular disorder characterized by delayed cardiac repolarization and an increased risk of arrhythmia. Many mutations have been identified that cause inherited long QT syndrome, but genotypes demonstrate incomplete ..
  60. Genomics of Cardiac Electrical Activity and Arrhythmia
    Nona Sotoodehnia; Fiscal Year: 2013
    ..Identifying the molecular determinants of cardiac electrical activity will provide insight into arrhythmia generation and potentially help target the development of novel therapies...
  61. Self-Regulation in Preschool: The Role of Child Physiology, Parents, and Teachers
    CATHI BARBRA PROPPER; Fiscal Year: 2013
    ..At two home visits (age 3.5 and 4.5), child self-regulation (behavior and respiratory sinus arrhythmia [RSA];vagal tone), temperament, early cognitive/executive functioning, and the parent-child relationship will be ..
  62. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..The effect of estrogen-replacement in post- menopausal women on arrhythmia vulnerability remains unknown...
  63. Rapid High-Resolution Electroanatomical Cardiac Mapping System for the Treatment
    DORON HARLEV; Fiscal Year: 2009
    ..Such maps are used to guide the delivery of ablative energy with the goal of abolishing the clinical arrhythmia(s)...
  64. ROLE OF PROLONGED REPOLARIZATION IN CARDIAC ARRHYTHMIAS
    Dan Roden; Fiscal Year: 1992
    ..Our initial clinical and in vitro studies of this arrhythmia- provoking action demonstrated that long cycle lengths and low extracellular potassium markedly potentiated the ..
  65. Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
    DANIEL EDWIN SINGER; Fiscal Year: 2010
    ..Atrial fibrillation is the most common clinically significant arrhythmia in adults and one of the most potent risk factors for ischemic stroke and other systemic thromboembolism...
  66. Differential 02 Sensing in Right and Left hearts: Crosstalk with Ca-Signaling
    Shahrzad Movafagh; Fiscal Year: 2009
    Acute oxygen deprivation leads to an array of events in the myocardium that include ischemic infarction, arrhythmia, cardiomyopathy, and heart failure...
  67. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    Atrial fibrillation is the most prevalent sustained cardiac arrhythmia, affecting over 2 million Americans...
  68. Circuit Weight Training and Blood Pressure Regulation in Prehypertension
    William Cooke; Fiscal Year: 2007
    ..weight training program on 1) resting arterial pressure; 2) sympathetic neural activity; 3) respiratory sinus arrhythmia and cardiovagal baroreflex sensitivity; and 4) central and peripheral arterial stiffness...
  69. CLOSED-LOOP IMPLANTABLE ANTIARRHYTHMIC DRUG INFUSION
    Robert Arzbaecher; Fiscal Year: 1993
    Our long term objective is the treatment of cardiac arrhythmia in the ambulatory patient by automatic infusion of antiarrhythmic drugs from an implanted pump...
  70. ECG MEASUREMENTS OF VENTRICULAR ARRHYTHMIA MECHANISMS
    EDWARD BERBARI; Fiscal Year: 1999
    ..Each of these measurements is aimed at quantifying some aspect of the arrhythmia mechanism...
  71. Cardiac Cryoablation Catheter
    RAN YARON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most frequent arrhythmia encountered in clinical practice and is the most common arrhythmia necessitating hospital admission. Nearly three million people in the U.S...
  72. Precise Micro-Steerable Mapping and Ablation Catheters for Treatment of Atrial Fi
    DEAN A ANDERSON; Fiscal Year: 2010
    ..Atrial fibrillation (AFib) is a common arrhythmia associated with significant morbidity. There are currently more than 2...