transposition of great vessels

Summary

Summary: A congenital cardiovascular malformation in which the aorta arises entirely from the right ventricle and the pulmonary artery from the left ventricle, so that the venous return from the peripheral circulation is recirculated by the right ventricle via the aorta to the systemic circulation without being oxygenated in the lungs.

Top Publications

  1. ncbi Risk factors for neo-aortic root enlargement and aortic regurgitation following arterial switch operation
    C J McMahon
    Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Cardiol 25:329-35. 2004
  2. ncbi Establishing right ventricle-pulmonary artery continuity by autologous tissue: an alternative approach for prosthetic conduit repair
    Yukihisa Isomatsu
    Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women s Medical University, Japan
    Ann Thorac Surg 78:173-80. 2004
  3. ncbi Long-term outcome in congenitally corrected transposition of the great arteries: a multi-institutional study
    T P Graham
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 2572, USA
    J Am Coll Cardiol 36:255-61. 2000
  4. ncbi Atrioventricular and ventriculoarterial discordance (congenitally corrected transposition of the great arteries): echocardiographic features, associations, and outcome in 34 fetuses
    G Sharland
    Guy s and St Thomas Foundation Trust, London, UK
    Heart 91:1453-8. 2005
  5. ncbi Transposition of the great arteries
    Carole A Warnes
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 114:2699-709. 2006
  6. ncbi Complete transposition of the great arteries: patterns of congenital heart disease in familial precurrence
    M C Digilio
    Departments of Medical Genetics and Pediatric Cardiology, , Rome
    Circulation 104:2809-14. 2001
  7. ncbi Right ventricular dysfunction in congenitally corrected transposition of the great arteries
    T S Hornung
    Adolph Basser Cardiac Institute, Department of Nuclear Medicine, Royal Alexandra Hospital for Children, Sydney, Australia
    Am J Cardiol 84:1116-9, A10. 1999
  8. ncbi Population-based study of l-transposition of the great arteries: possible associations with environmental factors
    Karen S Kuehl
    Department of Cardiology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    Birth Defects Res A Clin Mol Teratol 67:162-7. 2003
  9. ncbi [Transposition of great arteries. Understanding its pathogenesis]
    Bruno Marino
    Cattedra di Cardiologia Pediatrica Istituto di Pediatria Università degli Studi La Sapienza Viale Regina Elena, 324 00161 Roma
    Ital Heart J Suppl 3:154-60. 2002
  10. ncbi Outcome of 121 patients with congenitally corrected transposition of the great arteries
    J M Rutledge
    Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Cardiol 23:137-45. 2002

Research Grants

  1. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2009
  2. Cerebral Blood Flow in Single Ventricle and Normal Children Utilizing MRI
    MARK ALAN FOGEL; Fiscal Year: 2010
  3. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2005
  4. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2010
  5. Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)
    David Bellinger; Fiscal Year: 2007
  6. Effects of general vs. regional anesthesia on infant neurodevelopment and apnea
    Mary Ellen McCann; Fiscal Year: 2010
  7. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2009
  8. Cavopulmonary Assist: Circulatory Support for the Univentricular Fontan Circulat
    Mark D Rodefeld; Fiscal Year: 2010
  9. White Matter Injury in Critical Ill Newborns With Congenital Heart Disease
    Patrick Sean McQuillen; Fiscal Year: 2010
  10. Critical Period Plasticity Following Neonatal Brain Injury
    Patrick Sean McQuillen; Fiscal Year: 2010

Detail Information

Publications178 found, 100 shown here

  1. ncbi Risk factors for neo-aortic root enlargement and aortic regurgitation following arterial switch operation
    C J McMahon
    Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Cardiol 25:329-35. 2004
    ..Surgical intervention for AR was rare (2%), however, serial surveillance of such patients is vital to monitor for neo-aortic root enlargement and potential aortic valve dysfunction...
  2. ncbi Establishing right ventricle-pulmonary artery continuity by autologous tissue: an alternative approach for prosthetic conduit repair
    Yukihisa Isomatsu
    Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women s Medical University, Japan
    Ann Thorac Surg 78:173-80. 2004
    ..This study was undertaken to compare long-term results of the use of equine pericardial conduits, autologous pericardial conduits, and direct anastomosis repair...
  3. ncbi Long-term outcome in congenitally corrected transposition of the great arteries: a multi-institutional study
    T P Graham
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 2572, USA
    J Am Coll Cardiol 36:255-61. 2000
    ..The purpose of this study was to determine long-term outcome in adults with congenitally corrected transposition of the great arteries (CCTGA), with particular emphasis on systemic ventricular dysfunction and congestive heart failure (CHF)...
  4. ncbi Atrioventricular and ventriculoarterial discordance (congenitally corrected transposition of the great arteries): echocardiographic features, associations, and outcome in 34 fetuses
    G Sharland
    Guy s and St Thomas Foundation Trust, London, UK
    Heart 91:1453-8. 2005
    ..To identify fetal echocardiographic features, associations, and outcome of atrioventricular and ventriculoarterial discordance...
  5. ncbi Transposition of the great arteries
    Carole A Warnes
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 114:2699-709. 2006
    ..All patients should be seen periodically in a center where expertise in the clinical evaluation, imaging, and hemodynamic assessment of adult congenital heart disease is available...
  6. ncbi Complete transposition of the great arteries: patterns of congenital heart disease in familial precurrence
    M C Digilio
    Departments of Medical Genetics and Pediatric Cardiology, , Rome
    Circulation 104:2809-14. 2001
    ....
  7. ncbi Right ventricular dysfunction in congenitally corrected transposition of the great arteries
    T S Hornung
    Adolph Basser Cardiac Institute, Department of Nuclear Medicine, Royal Alexandra Hospital for Children, Sydney, Australia
    Am J Cardiol 84:1116-9, A10. 1999
    ..6 +/- 2.3 of a total of 12 segments; the extent of the resting perfusion defects correlated inversely with the RV ejection fraction...
  8. ncbi Population-based study of l-transposition of the great arteries: possible associations with environmental factors
    Karen S Kuehl
    Department of Cardiology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    Birth Defects Res A Clin Mol Teratol 67:162-7. 2003
    ..L-transposition of the great arteries (l-tga) is an uncommon congenital cardiovascular malformation that occurs from abnormal looping of the primitive cardiac tube. Little is known about risk factors for the development of l-tga...
  9. ncbi [Transposition of great arteries. Understanding its pathogenesis]
    Bruno Marino
    Cattedra di Cardiologia Pediatrica Istituto di Pediatria Università degli Studi La Sapienza Viale Regina Elena, 324 00161 Roma
    Ital Heart J Suppl 3:154-60. 2002
    ..The mystery is still present but perhaps some gleams of light are appearing...
  10. ncbi Outcome of 121 patients with congenitally corrected transposition of the great arteries
    J M Rutledge
    Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Cardiol 23:137-45. 2002
    ..We support a move toward an alternative surgical approach (double switch procedure) in carefully selected patients...
  11. ncbi Catheter management of occluded superior baffle after atrial switch procedures for transposition of great vessels
    Makram R Ebeid
    Department of Pediatrics Cardiology, The University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Cardiol 95:782-6. 2005
    ..Additionally, we report the regression of multiple systemic-to-pulmonary venous fistulas that developed as a result of the occluded baffle...
  12. ncbi Intermediate results of the anatomic repair for congenitally corrected transposition
    Michel N Ilbawi
    University of Illinois at Chicago, The Heart Institute for Children, Hope Children's Hospital, Oak Lawn, Illinois 60453, USA
    Ann Thorac Surg 73:594-9; discussion 599-600. 2002
    ..6%), and ejection fraction was 49% to 70% (mean, 60.8%+/-7.9%). CONCLUSIONS: The double switch operation can be performed safely with minimal intermediate and long-term complications...
  13. ncbi CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle
    Elizabeth Goldmuntz
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Hum Genet 70:776-80. 2002
    ..In addition, these results demonstrate that the molecular pathway involving CFC1 plays a critical role in normal and abnormal cardiovascular development...
  14. ncbi Surgical management and indication of left ventricular retraining in arterial switch for transposition of the great arteries with intact ventricular septum
    F Lacour-Gayet
    Marie Lannelongue Hospital, Paris Sud University, 133 avenue de la Resistance, 92350 Le Plessis Robinson, Paris, France
    Eur J Cardiothorac Surg 20:824-9. 2001
    ..In cases of late referral, perinatal complications or early left ventricular (LV) dysfunction, the one stage arterial switch is contra indicated. Anatomical repair remains possible in these patients following a LV retraining...
  15. ncbi Early and late results of operations for defects associated with corrected transposition and other anomalies with atrioventricular discordance in a pediatric population
    G Biliciler-Denktas
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA
    J Thorac Cardiovasc Surg 122:234-41. 2001
    ..CONCLUSIONS: These results can serve as a basis for comparison with newer surgical alternatives proposed for corrected transposition of the great arteries...
  16. ncbi Repair of transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction
    Jeong Ryul Lee
    Department of Thoracic and Cardiovascular Surgery, Seoul National University Children s Hospital, Seoul National University College of Medicine, Seoul National University Medical Research Center, Jongro Gu, Seoul 110 744, South Korea
    Eur J Cardiothorac Surg 25:735-41. 2004
    ....
  17. ncbi Two-stage arterial switch operation: is late ever too late?
    Howaida O Al Qethamy
    Department of Cardiac Surgery Prince Sultan Cardiac Centre Riyadh Military Hospital Riyadh, Saudi Arabia
    Asian Cardiovasc Thorac Ann 10:235-9. 2002
    ....
  18. ncbi Long-term outcome of surgically treated patients with corrected transposition of the great arteries
    Viktor Hraska
    Department of Pediatric Cardiac Surgery, University Hospital Hamburg-Eppendorf, Germany
    J Thorac Cardiovasc Surg 129:182-91. 2005
    ..Alternative surgical approaches, such as the double-switch, Senning-Rastelli, or Fontan procedures, are likely to have better long-term results, especially in the highest risk groups...
  19. ncbi Late outcome of Senning and Mustard procedures for correction of transposition of the great arteries
    L Dos
    Department of General Cardiology, Hospital Materno-Infantil Vall d'Hebron, Barcelona, Spain
    Heart 91:652-6. 2005
    ..Nevertheless, better outcomes may be offered through improved diagnostic methods for right ventricular function and better management of supraventricular tachyarrhythmias...
  20. ncbi Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries)
    Nadja Muncke
    Institut fur Humangenetik, Universitat Heidelberg, Heidelberg, Germany
    Circulation 108:2843-50. 2003
    ..TGA represents a septation defect of the common outflow tract of the heart, manifesting around the fifth week during embryonic development. Despite its high prevalence, very little is known about the pathogenesis of this disease...
  21. ncbi Outcomes of definitive surgical repair for congenitally corrected transposition of the great arteries or double outlet right ventricle with discordant atrioventricular connections: risk analyses in 189 patients
    Toshiharu Shin'oka
    Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    J Thorac Cardiovasc Surg 133:1318-28, 1328.e1-4. 2007
    ....
  22. ncbi Results of the double switch operation for congenitally corrected transposition of the great arteries
    Brian W Duncan
    Pediatric and Congenital Heart Surgery, The Children s Hospital at the Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA
    Eur J Cardiothorac Surg 24:11-9; discussion 19-20. 2003
    ..To determine the outcomes for a program that utilizes the double switch operation as the primary approach for congenitally corrected transposition...
  23. ncbi Midterm results after restoration of the morphologically left ventricle to the systemic circulation in patients with congenitally corrected transposition of the great arteries
    Stephen M Langley
    Department of Cardiac Surgery, Diana Princess of Wales Children s Hospital, Birmingham, United Kingdom
    J Thorac Cardiovasc Surg 125:1229-41. 2003
    ..This study was undertaken to determine the outcomes of patients with congenitally corrected transposition of the great arteries after restoration of the morphologically left ventricle to the systemic circulation...
  24. ncbi Aortic translocation in the management of transposition of the great arteries with ventricular septal defect and pulmonary stenosis: results and follow-up
    Victor O Morell
    Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann Thorac Surg 79:2089-92; discussion 2092-3. 2005
    ..The objective in this retrospective study was to review our experience using aortic translocation and biventricular outflow tract reconstruction as an alternative surgical procedure for the management of these patients...
  25. ncbi Technical aspects of the Rastelli and atrial switch procedure for congenitally corrected transposition of the great arteries with ventricular septal defect and pulmonary stenosis or atresia: results of therapy
    William J Brawn
    Birmingham's Children's Hospital NHS Trust, Diana, Princess of Wales Children's Hospital, Birmingham, UK
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 6:4-8. 2003
    ..A disadvantage is that these patients require valved conduit changes over the years...
  26. ncbi Sequential diagnosis of coronary arterial anatomy in congenitally corrected transposition of the great arteries
    Ing Sh Chiu
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Ann Thorac Surg 75:422-9; discussion 429. 2003
    ..Precise CA anatomy is surgically needed in the current era of double switch for CCT...
  27. ncbi Follow-up outcomes 10 years after arterial switch operation for transposition of the great arteries: comparison of cardiological health status and health-related quality of life to those of the a normal reference population
    Wilfred B de Koning
    Department of Paediatrics Division of Cardiology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Pediatr 167:995-1004. 2008
    ..Aortic root dilatation is frequent, irrespective of the anatomical subgroup. Severe aortic regurgitation or left ventricular dilatation was not found. The unfavourable health-related quality of life deserves further attention...
  28. ncbi Preoperative identification of coronary arterial anatomy in complete transposition, and outcome after the arterial switch operation
    Colin J McMahon
    Section of Pediatric Cardiology, Division of Congenital Heart Surgery, LillieFrank Abercrombie Division of Pediatric Cardiology, Texas Children s Hospital, 6621 Fannin, Houston, Texas 77030, USA
    Cardiol Young 12:240-7. 2002
    ..Perceived correlation between the coronary arterial anatomy in patients with complete transposition, and the outcome of the arterial switch procedure, has made preoperative identification of their patterns standard practice...
  29. ncbi Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides
    C A Loffredo
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Epidemiol 153:529-36. 2001
    ..6). No data were collected on specific chemicals or brand names. These results raise new questions about the possible epidemiologic association of TGA with some classes of pesticides and warrant new, carefully targeted investigations...
  30. ncbi Extending the surgical boundaries in the management of the left ventricular outflow tract obstruction in discordant ventriculo-arterial connections--a surgical and morphological study
    Paula Martins
    Paediatric Cardiology Department, Paediatric Hospital of Coimbra, Portugal
    Cardiol Young 18:124-34. 2008
    ..In this review, we assess all these surgical and anatomic aspects, focussing on their relative importance in clinical assessment...
  31. ncbi Transposition of the great arteries
    Paula Martins
    Serviço de Cardiologia Pediátrica, Hospital Pediátrico de Coimbra, Coimbra, Portugal
    Orphanet J Rare Dis 3:27. 2008
    ..However, the exercise performance, cognitive function and quality of life may be impaired...
  32. ncbi A multiple retinoic acid antagonist induces conotruncal anomalies, including transposition of the great arteries, in mice
    Daria Cipollone
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, 00173 Rome, Italy
    Cardiovasc Pathol 15:194-202. 2006
    ..CONCLUSIONS: Transposition of the great arteries can be consistently reproduced in mice by administration of a retinoic acid competitive antagonist on 7.5 dpc...
  33. ncbi Anatomic repair for congenitally corrected transposition of the great arteries
    Rajesh Sharma
    Narayana Hrudayalaya Institute of Cardiac Sciences, Bangalore, India
    J Thorac Cardiovasc Surg 137:404-412.e4. 2009
    ..Anatomic repair is being actively evaluated as the preferred option for congenitally corrected transposition of the great arteries. We present our 13-year experience with this approach...
  34. ncbi Progressive tricuspid valve disease in patients with congenitally corrected transposition of the great arteries
    L R Prieto
    Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Circulation 98:997-1005. 1998
    ..The relative importance of these factors in long-term outcome has not been evaluated...
  35. ncbi The morphologic left ventricle that requires training by means of pulmonary artery banding before the double-switch procedure for congenitally corrected transposition of the great arteries is at risk of late dysfunction
    David W Quinn
    Department of Cardiac Surgery, Birmingham Children s Hospital NHS Trust, Birmingham, United Kingdom
    J Thorac Cardiovasc Surg 135:1137-44, 1144.e1-2. 2008
    ....
  36. ncbi Neonatal death due to transposition in association with premature closure of the oval foramen
    Michael Ashworth
    Department of Paediatric Histopathology, Great Ormond Street Hospital, London, UK
    Cardiol Young 16:586-9. 2006
    ..Premature closure of the oval foramen is rare in the setting of transposition. As far as we know, there have been only three previously reported cases...
  37. ncbi Detection of transposition of the great arteries in fetuses reduces neonatal morbidity and mortality
    D Bonnet
    Service de Cardiologie Pediatrique, Hopital Necker Enfants Malades, Paris, France
    Circulation 99:916-8. 1999
    ..Transposition of the great arteries (TGA) is a life-threatening malformation in neonates, but it is amenable to complete repair. Prenatal detection, diagnosis, and early management may modify neonatal mortality and mortality...
  38. ncbi Double switch for congenitally corrected transposition of the great arteries
    R Sharma
    Cardio Thoracic Centre, All India Institute of Medical Sciences, New Delhi
    Eur J Cardiothorac Surg 15:276-81; discussion 281-2. 1999
    ..To evaluate the early and medium term results of operations for congenitally corrected transposition of the great arteries (CCTGA) wherein the left ventricle becomes the systemic ventricle...
  39. ncbi Familial transposition of the great arteries caused by multiple mutations in laterality genes
    Alessandro De Luca
    Mendel Laboratory, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Heart 96:673-7. 2010
    ..In general, TGA is not associated with the more common genetic disorders nor with extracardiac anomalies, whereas it can be found in individuals with lateralisation defects, heterotaxy and asplenia syndrome (right isomerism)...
  40. ncbi X-linked transposition of the great arteries and incomplete penetrance among males with a nonsense mutation in ZIC3
    A Megarbane
    Unite de Genetique Medicale, Faculte de Medecine, Université Saint Joseph, Beirut
    Eur J Hum Genet 8:704-8. 2000
    ..To our knowledge, this is the first instance of incomplete penetrance in a male for a mutation in a chromosome X gene...
  41. ncbi Twenty-five-year experience with rastelli repair for transposition of the great arteries
    C Kreutzer
    Departments of Cardiology and Cardiac Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 120:211-23. 2000
    ..Our purpose was to describe the outcome of the Rastelli repair in D -transposition of the great arteries and to determine the risk factors associated with unfavorable events...
  42. ncbi Congenital Heart Surgery Nomenclature and Database Project: transposition of the great arteries
    J J Jaggers
    Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 69:S205-35. 2000
    ..These data can lay the foundation for comprehensive risk stratification analyses. A minimum database set is also presented which will allow for data sharing and would lend itself to basic interpretation of trends...
  43. ncbi Late reoperations after neonatal arterial switch operation for transposition of the great arteries
    Emanuela Angeli
    Department of Pediatric Cardiac Surgery, University Paris Descartes and Sick Children Hospital, Paris, France
    Eur J Cardiothorac Surg 34:32-6. 2008
    ..Left ventricular function is maintained in the vast majority of patients. Reoperation may be indicated in some patients for other reasons: mitral valve malformation, tracheo-bronchial compression or pulmonary hypertension...
  44. ncbi Noncardiac malformations in congenital heart disease: a retrospective analysis of 305 pediatric autopsies
    Safak Gucer
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 47:159-66. 2005
    ..Proper identification and treatment of CHD early in the prenatal period will save the family from the economic and emotional burden caused by having such a child with CHD...
  45. ncbi Production of proinflammatory cytokines and myocardial dysfunction after arterial switch operation in neonates with transposition of the great arteries
    Hedwig H Hövels-Gürich
    Department of Pediatric Cardiology, Institute of Biomedical Statistics, Aachen University of Technology, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Thorac Cardiovasc Surg 124:811-20. 2002
    ..The purpose of this study was to test the hypothesis that the production of proinflammatory cytokines during cardiac surgery would be associated with myocardial dysfunction after the arterial switch operation in neonates...
  46. ncbi Late outcome after arterial switch operation for transposition of the great arteries
    J Losay
    Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
    Circulation 104:I121-6. 2001
    ..Early and midterm results of the arterial switch operation (ASO) in transposition of the great arteries (TGA) are good, but late outcome data in large populations are still few...
  47. ncbi Long term outcome up to 30 years after the Mustard or Senning operation: a nationwide multicentre study in Belgium
    P Moons
    Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Heart 90:307-13. 2004
    ..To assess long term outcome of patients who underwent Mustard or Senning repair for transposition of the great arteries up to 30 years earlier...
  48. ncbi Newborn patients exhibit an unusual pattern of interleukin 10 and interferon gamma serum levels in response to cardiac surgery
    A J Alcaraz
    Department of Pediatrics and Pediatric Surgery, Pediatric Intensive Care Unit, , Madrid, Spain
    J Thorac Cardiovasc Surg 123:451-8. 2002
    ..This cytokine imbalance could have potential clinical implications...
  49. ncbi The year in congenital heart disease
    Thomas P Graham
    Division of Pediatric Cardiology, Vanderbilt Children' s Hospital, Nashville, Tennessee 37232-9119, USA
    J Am Coll Cardiol 50:368-77. 2007
  50. ncbi En bloc rotation of the truncus arteriosus--an option for anatomic repair of transposition of the great arteries, ventricular septal defect, and left ventricular outflow tract obstruction
    Rudolf Mair
    Department of Cardiac Surgery, General Hospital Linz, Austria
    J Thorac Cardiovasc Surg 131:740-1. 2006
  51. ncbi Long-term outcomes after the atrial switch for surgical correction of transposition: a meta-analysis comparing the Mustard and Senning procedures
    Paul Khairy
    Boston Adult Congenital Heart Service, Brigham and Women s Hospital, USA
    Cardiol Young 14:284-92. 2004
    ..We conclude that outcomes are not uniform among patients submitted to the Mustard and Senning procedures. Knowledge of such differences may facilitate stratification of risk and follow-up...
  52. ncbi [Surgical management of preterm infants and low birth weight neonates with congenital heart disease]
    Istvan Hartyanszky
    Gottsegen György Országos Kardiológiai Intézet, Gyermekszív Központ, Budapest
    Orv Hetil 146:69-73. 2005
    ..These patients are endangered because of their age as well, they require special treatment and the surgical treatment has always meant high risk, urgent interventions...
  53. ncbi Left-sided lesions after anatomic repair of transposition of the great arteries, ventricular septal defect, and coarctation: surgical factors
    Siamak Mohammadi
    Department of Pediatric Cardiac Surgery, Marie-Lannelongue Hospital, Le Plessis-Robinson, France
    J Thorac Cardiovasc Surg 128:44-52. 2004
    ..Avoidance of late recoarctation of the aorta and progressive neoaortic regurgitation requires meticulous closure of the ventricular septal defect and evenly sized reconstruction of the aorta from root to distal arch...
  54. ncbi Long-term predictors of aortic root dilation and aortic regurgitation after arterial switch operation
    Marcy L Schwartz
    Department of Cardiology, Children s Hospital, 300 Longwood Avenue, Boston, Mass 02115, USA
    Circulation 110:II128-32. 2004
    ..Neo-aortic root dilation (ARD) and neo-aortic regurgitation (AR) may be progressive after arterial switch operation (ASO) for d-loop transposition of the great arteries (dTGA). We sought to identify predictors of ARD and AR after ASO...
  55. ncbi Early and mid-term outcome of the arterial switch operation in 114 consecutive patients : A single centre experience
    C Prandstetter
    Department of Peadiatric Cardiology, Children s Heart Centre Linz, Krankenhausstrasse 26 30, 4020 Linz, Austria
    Clin Res Cardiol 96:723-9. 2007
    ..The purpose of this study was to assess early and mid-term outcome after ASO in a single centre...
  56. ncbi Valved bovine jugular vein conduits for right ventricular outflow tract reconstruction in children: an attractive alternative to pulmonary homograft
    John W Brown
    Section of Cardiothoracic Surgery, James W Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202 5123, USA
    Ann Thorac Surg 82:909-16. 2006
    ..Recently a valve-containing bovine jugular vein (Contegra, Medtronic, Inc, Minneapolis, MN) was introduced for clinical trials for a variety of patients requiring RVOT reconstruction...
  57. ncbi Primary surgical correction of transposition of the great arteries and atrioventricular septal defect associated with left isomerism
    S Kikuchi
    Department of Cardiovascular Surgery, Hokkaido Children s Hospital and Medical Center, Zenibako 1 10 1 Otaru, Hokkaido, 047 0261, Japan
    Pediatr Cardiol 27:124-7. 2006
    ..To the best of our knowledge, this is the first report of successful primary surgical repair of TGA and AVSD with left isomerism. Primary anatomic correction of this defect combination is feasible in patients with left isomerism...
  58. ncbi Serum cardiac troponin-I elevation in neonatal cardiac surgery is lesion-dependent
    Neeta R Saraiya
    Department of Anesthesiology, Columbia University, New York, NY 10032, USA
    J Cardiothorac Vasc Anesth 19:620-5. 2005
    ..46 +/- 3.5 ng/mL). CONCLUSION: It was found that perioperative elevations in serum cTn-I in neonates with TGA and HLHS were influenced by duration of aortic cross-clamp application, CPB, and the presence of VSD...
  59. ncbi Postoperative prophylactic peritoneal dialysis in neonates and infants after complex congenital cardiac surgery
    Tijen Alkan
    V.K.V. American Hospital, Department of Cardiovascular Surgery, Istanbul, Turkey
    ASAIO J 52:693-7. 2006
    ....
  60. ncbi Mid-term follow-up of neoaortic regurgitation after the arterial switch operation for transposition of the great arteries
    Ho Young Hwang
    Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, Seoul National University, College of Medicine, Seoul National University Children's Hospital, 28 Yongon-dong, Jongro-gu, Seoul 110-744, South Korea
    Eur J Cardiothorac Surg 29:162-7. 2006
    ..CONCLUSIONS: Neoaortic valve regurgitation progressed after the arterial switch operation. The degree of regurgitation was more severe in patients with a size discrepancy between the aorta and the pulmonary artery preoperatively...
  61. ncbi Prevalence of arrhythmias and their risk factors mid- and long-term after the arterial switch operation
    George Hayashi
    Department of Pediatrics, Shimane University School of Medicine, 89 1, Enya cho, Izumo City, Shimane, 693 8501, Japan
    Pediatr Cardiol 27:689-94. 2006
    ..VSD was a risk factor for postoperative arrhythmia, especially CAVB. Approximately half of the arrhythmias developed late. Lifelong monitoring with respect to arrhythmia is needed for patients after ASO...
  62. ncbi Late coronary artery lesions after neonatal arterial switch operation: results of surgical coronary revascularization
    Olivier Raisky
    Department of Pediatric Cardiac Surgery, University Paris Descartes and Sick Children Hospital, Paris, France
    Eur J Cardiothorac Surg 31:894-8. 2007
    ..To evaluate the results of surgical revascularization in children with coronary artery lesions following neonatal arterial switch operation (ASO)...
  63. ncbi The optimal procedure for the great arteries and left ventricular outflow tract obstruction. An anatomical study
    Mark Hazekamp
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cardiothorac Surg 31:879-87. 2007
    ..To describe the optimal surgical strategy in heart specimens with transposition of the great arteries (TGA) and left ventricular outflow tract obstruction (LVOTO)...
  64. ncbi Acquired coronary artery fistula after open heart surgery for congenital heart disease
    Shuenn-Nan Chiu
    Department of Pediatrics, National Taiwan University Hospital, School of Medicine, National Taiwan University, 7 Chung-Shan S. Rd, Taipei 100, Taiwan
    Int J Cardiol 103:187-92. 2005
    ..Although shunt flow did not increase during follow-up, the significance of acquired coronary artery fistula needs further investigation...
  65. ncbi Unusual and early hyperglycemia following amiodarone infusion in two infants
    S V Yildirim
    Division of Pediatric Cardiology, Baskent University, Faculty of Medicine, Ankara, Turkey
    Pediatr Cardiol 26:715-6. 2005
    ..We present two infants who had hyperglycemia following amiodarone infusion during the early postoperative period...
  66. ncbi Surgery for right ventricle to pulmonary artery conduit obstruction: risk factors for further reoperation
    Siamak Mohammadi
    Department of Pediatric Cardiac Surgery, Marie Lannelongue Hospital, 133 ave de la Résistance, 92350 Le Plessis Robinson, France
    Eur J Cardiothorac Surg 28:217-22. 2005
    ..To identify the surgical approaches and risk factors which influence longevity of right ventricle to pulmonary artery (RV-PA) conduits following first reoperation for obstruction...
  67. ncbi Surgical results of arterial switch operation for Taussig-Bing anomaly: is position of the great arteries a risk factor?
    Mark D Rodefeld
    Section of Cardiothoracic Surgery, James W Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, Indiana 46202 5123, USA
    Ann Thorac Surg 83:1451-7. 2007
    ..This study identifies the impact of the position of the great arteries and use of a staged surgical approach on the outcome after the arterial switch operation in children with Taussig-Bing anomaly...
  68. ncbi Surgical management of transposition with ventricular septal defect and obstruction to the left ventricular outflow tract
    Victor O Morell
    Division of Cardiothoracic Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh, PA 15213, USA
    Cardiol Young 15:102-5. 2005
  69. ncbi Is preoperative delineation of coronary artery pattern a prerequisite for arterial switch operation?
    Ghassan M Baslaim
    Division of Cardiothoracic Surgery, Department of Cardiovascular Diseases, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
    J Card Surg 21:465-70. 2006
    ..To determine the effect of preoperative echocardiographic delineation of coronary artery pattern on the immediate postoperative result of arterial switch procedures...
  70. ncbi Chromosome 22q11 deletions in patients with conotruncal heart defects
    A Khositseth
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
    Pediatr Cardiol 26:570-3. 2005
    ..A subgroup of patients with IAA, TA, SPVSD, and PAVSD associated with phenotypic features or abnormalities warrants evaluation for the presence of 22q11 deletions...
  71. ncbi State of the art of cardiac surgery in patients with congenital heart disease
    Lucio Zannini
    Division of Pediatric Cardiac Surgery, IRCCS Giannina Gaslini, Genoa, Italy
    J Cardiovasc Med (Hagerstown) 8:3-6. 2007
    ....
  72. ncbi [Arterial switch operation for transposition of the great arteries and double outlet of right ventricle with subpulmonary ventricular septum defect]
    Zhi-Wei Xu
    Department of Thoracic and Cardiovascular Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200127, China
    Zhonghua Wai Ke Za Zhi 42:451-4. 2004
    ..The procedure used in treatment on Taussig-Bing can prevent pulmonary obstruction and avoid the complication of left ventricular outflow tract obstruction caused by intraventricular repair...
  73. ncbi Risk factors for mortality after the Norwood procedure
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Suite 8527, Philadelphia, PA 19104, USA
    Eur J Cardiothorac Surg 22:82-9. 2002
    ..The current study was undertaken to evaluate our recent experience with the Norwood procedure and to evaluate potential predictors of operative and 1-year mortality...
  74. ncbi Arterial switch operation with a single coronary artery
    Albertus M Scheule
    Department of Cardiac Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 123:1164-72. 2002
    ..Risk of reintervention is higher in patients having a single left ostium with the right coronary artery anterior to the aorta...
  75. ncbi [Double switch operation (Senning and Rastelli operation) with left atrial augumentation by in situ autologous pericardium: a case report]
    M Ogawa
    Department of Pediatric Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Kyobu Geka 54:1099-102. 2001
    ..For the purpose of atrial augumentation without artificial materials, our modified Senning procedure is useful. But longer follow-up is necessary to determine whether this technique is indeed beneficial...
  76. ncbi Aneurysmal pericardial patch producing right ventricular inflow obstruction
    G B Bennink
    Department of Cardiology, Wilhelmina Children's Hospital, Utrecht, The Netherlands
    Ann Thorac Surg 71:1346-7. 2001
    ..Echocardiography demonstrated aneurysmal dilation of the native pericardial patch used for VSD closure, resulting in right ventricular inflow obstruction. The pericardial patch was excised, and the VSD closed using a GoreTex patch...
  77. ncbi Arterial switch operation for transposition of the great arteries combined with closure of paramembranous ventricular septal defect using the Amplatzer membranous ventricular septal occluder
    Hakan Akintuerk
    Pediatric Heart Center, Justus-Liebig University, Giessen, Germany
    Am J Cardiol 96:592-4. 2005
    ..The cardiac arrest time for anatomic repair might be effectively reduced by this new approach in pediatric cardiac surgery...
  78. ncbi Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery
    Jane W Newburger
    Department of Cardiology, Children s Hospital Boston, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 135:347-54, 354.e1-4. 2008
    ..However, worse outcomes were concentrated in patients with hematocrit values of 20% or below, and the benefits of hematocrit values higher than 25% were uncertain...
  79. ncbi Long-term outcomes and social independence level after arterial switch operation
    Akira Yamazaki
    Department of Cardiovascular Surgery, Tokyo Women s Medical University, Japan
    Eur J Cardiothorac Surg 33:239-43. 2008
    ..Various issues regarding the long-term survivors of arterial switch operation (ASO) have been clarified according to the improvement of surgical mortality. We reviewed the long-term results and social independence level after ASO...
  80. ncbi [Arterial switch operation: late results and a future perspective]
    Mitsuru Aoki
    Department of Cardiovascular Surgery, Chiba Children s Hospital, Chiba, Japan
    Kyobu Geka 61:268-73. 2008
    ..Risk factors for aortic regurgitation were age at operation and prior PAB. Early primary arterial switch operation may resolve these problems...
  81. ncbi [Long term outcome of arterial switch surgery for transposition of the great arteries: evaluation of the reconstruction of the pulmonary artery]
    Hiroaki Kawata
    Department of Cardiovascular Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan
    Kyobu Geka 61:303-9. 2008
    ....
  82. ncbi Predictors of outcome of arterial switch operation for complex D-transposition
    Danielle Gottlieb
    Department of Cardiology and Cardiovascular Surgery, Children s Hospital Boston, Boston, Massachusetts, USA
    Ann Thorac Surg 85:1698-702; discussion 1702-3. 2008
    ..D-TGA with ventricular septal defect (VSD) and aortic arch obstruction (AAO) is a higher risk subgroup in which we sought risk factors for mortality and reoperation after ASO...
  83. ncbi [Double discordances with ventricular septal defect and pulmonary obstruction. A study of 72 cases]
    P Acar
    , , Paris
    Arch Mal Coeur Vaiss 90:625-9. 1997
    ..Therefore, there is no place for elective surgery in this malformation: when necessary, the best option is to remain palliative as long as possible: when correction is required, an anatomical correction is the best procedure...
  84. ncbi Determinants of right ventricular outflow tract conduit longevity: a multinational analysis
    Marieke B A Niemantsverdriet
    Pediatric Cardiology, Center for Congenital Abnormalities of Heart, Amsterdam Leiden, The Netherlands
    Congenit Heart Dis 3:176-84. 2008
    ..We compared two diverse surgical centers with considerable practice variation in Europe and the United States to identify modifiable risk factors that can increase conduit longevity...
  85. ncbi Arterial switch operation: troponin T does not predict ventilation requirements
    Madan M Maddali
    Departments of Anesthesia and Cardiothoracic Surgery, Royal Hospital, Seeb, Muscat, Sultanate of Oman
    Asian Cardiovasc Thorac Ann 16:274-7. 2008
    ..It was concluded that the postoperative cardiac troponin T level is not a predictor of successful extubation or prolonged artificial ventilation in this subset...
  86. ncbi [Double outlet left ventricle: a rare and unusual cardiopathy. Apropos of 7 new cases]
    M Gouton
    , Lyon
    Arch Mal Coeur Vaiss 89:553-9. 1996
    ..The anatomical variability is due to the complex embryogenesis of the conotruncal region and explains the clinical diversity of this congenital cardiac malformation...
  87. ncbi [Systemic pulmonary shunts in the neonatal period. Short and medium-term results]
    A Chantepie
    , , CHU de Tours
    Arch Mal Coeur Vaiss 88:693-8. 1995
    ..Cardiac failure occurred in 83% of group B and 22% of group A (p < 0.01). The probability of shunt efficacy was 89% at 1 year, 63% at 2 years and 45% at 3 years.(ABSTRACT TRUNCATED AT 250 WORDS)..
  88. ncbi Early and long term outcome of the arterial switch operation for transposition of the great arteries: predictors and functional evaluation
    Edvin Prifti
    G Pasquinucci Hospital, CREAS IFC CNR, Via Aurelia Sud, 54100 Massa, Italy
    Eur J Cardiothorac Surg 22:864-73. 2002
    ....
  89. ncbi Obliteration of a competitive forward flow from the ventricle after a bidirectional cavopulmonary shunt with an Amplatzer duct occluder
    Carlo B Pilla
    , , Brazil
    J Invasive Cardiol 15:98-101. 2003
    ..After test occlusion, an Amplatzer duct occluder was implanted at the PA banding site with subsequent decrease in the PA pressure, resolution of the edema and extubation...
  90. ncbi Technical aspects of the combined arterial switch and senning operation for congenitally corrected transposition of the great arteries
    Eric J Devaney
    Section of Cardiac Surgery, Division of Pediatric Cardiac Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 6:9-15. 2003
    ..Anatomic repair by double switch technique may improve survival of patients with ccTGA by establishing the morphologic left ventricle in the systemic circulation...
  91. ncbi Current expectations for newborns undergoing the arterial switch operation
    Daniel J Dibardino
    Division of Congenital Heart Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine and Texas Children's Hospital, 6621 Fannin Street, Houston, TX 77030, USA
    Ann Surg 239:588-96; discussion 596-8. 2004
    ..CONCLUSIONS: Using current methodologies, the ASO can be performed safely and with a low incidence of need for reoperation on intermediate follow-up. Recent experience indicates operative survival rates approaching 100%...
  92. ncbi Application of modified perfusion technique on one stage repair of interrupted aortic arch in infants: a case series and literature review
    Jinping Liu
    Department of Cardiopulmonary Bypass, Fuwai Hospital, CAMD and PUMS, Beijing, China
    ASAIO J 53:666-9. 2007
    ....
  93. ncbi Long-term results of left ventricular reconditioning and anatomic correction for systemic right ventricular dysfunction after atrial switch procedures
    Nancy C Poirier
    Ste-Justine Hospital, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 127:975-81. 2004
    ..It is an alternative to cardiac transplantation in selected patients, with good long-term results. The response to morphologically left ventricular reconditioning past adolescence is inconsistent...
  94. ncbi Functional acquired pulmonary atresia secondary to subpulmonary aneurysmal tissue: a rare form of pulmonary outflow tract obstruction
    Grace C Kung
    Department of Pediatrics, Baylor College of Medicine, 6621 Fannin, Houston, TX, USA
    J Am Soc Echocardiogr 17:284-5. 2004
  95. ncbi [MRI of congenital heart disease in childhood]
    F Weiss
    Radiologisches Zentrum, Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitatsklinikum Hamburg Eppendorf
    Rofo 176:191-9. 2004
    ..The aim of this article is to impart knowledge, to mention problems and to provide guidance in the performance of cardiac MRI in patients with CHD...
  96. ncbi Abnormal origin of the right subclavian artery from the right pulmonary artery in a patient with D-transposition of the great vessels and left juxtaposition of the right atrial appendage: an unusual anatomical variant
    Jackmerry Mosieri
    Department of Cardiovascular Surgery, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Card Surg 19:41-4. 2004
    ..We discuss the embryological basis of this anomaly and review its clinical and surgical implications...
  97. ncbi Transcatheter occlusion of baffle leaks following atrial switch procedures for transposition of the great vessels (d-TGV)
    David T Balzer
    Division of Pediatric Cardiology, Department of Pediatric, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri, USA
    Catheter Cardiovasc Interv 61:259-63. 2004
    ....
  98. ncbi The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial
    David Wypij
    Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, 02115, USA
    J Thorac Cardiovasc Surg 126:1397-403. 2003
    ....
  99. ncbi Long term follow-up of left ventricular performance and size of the great arteries before and after one- and two-stage arterial switch operation of simple transposition
    Hans Heiner Kramer
    Department of Pediatric Cardiology, Christian Albrechts University, Schwanenweg 20, 24105, Kiel, Germany
    Eur J Cardiothorac Surg 24:898-905. 2003
    ..Long-term angiographic evaluation of left ventricular performance and size of the great arteries after one-stage neonatal versus two-stage arterial switch operation (ASO) of simple transposition...
  100. ncbi Apico-pulmonary artery conduit repair of congenitally corrected transposition of the great arteries with ventricular septal defect and pulmonary outflow tract obstruction: a 10-year follow-up
    Ryo Aeba
    Division of Cardiovascular Surgery, Keio University, Shinjuku, Tokyo, Japan
    Ann Thorac Surg 76:1383-7; discussion 1387-8. 2003
    ....
  101. ncbi "Bay window" technique for the arterial switch operation of the transposition of the great arteries with complex coronary arteries
    Masaaki Yamagishi
    Department of Pediatric Cardiovascular Surgery, Children s Research Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Ann Thorac Surg 75:1769-73; discussion 1773-4. 2003
    ..Early and midterm results of this technique are described...

Research Grants48

  1. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2009
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  2. Cerebral Blood Flow in Single Ventricle and Normal Children Utilizing MRI
    MARK ALAN FOGEL; Fiscal Year: 2010
    ..Changing the way the blood flows in these patients by surgery may alter the way we ultimately manage these patients medically and surgically. ..
  3. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2005
    ..abstract_text> ..
  4. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2010
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  5. Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)
    David Bellinger; Fiscal Year: 2007
    ..Members of the faculty currently conduct a wealth of multidisciplinary research, which will provide trainees with ready opportunities to apply their training in ongoing research projects. ..
  6. Effects of general vs. regional anesthesia on infant neurodevelopment and apnea
    Mary Ellen McCann; Fiscal Year: 2010
    ..If general and regional awake anesthesia result in neurodevelopmental outcomes that are equivalent, this would support the safety of general anesthetics as currently used. ..
  7. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2009
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  8. Cavopulmonary Assist: Circulatory Support for the Univentricular Fontan Circulat
    Mark D Rodefeld; Fiscal Year: 2010
    ..This will dramatically improve the healthcare of children and adults born with single ventricle heart disease. ..
  9. White Matter Injury in Critical Ill Newborns With Congenital Heart Disease
    Patrick Sean McQuillen; Fiscal Year: 2010
    ..Page McQuillen, Patrick S. ..
  10. Critical Period Plasticity Following Neonatal Brain Injury
    Patrick Sean McQuillen; Fiscal Year: 2010
    ..Understanding plasticity following injury will provide both a new outcome measure and a model to guide therapy for recovering brain function. ..
  11. Iron and Atherosclerosis
    Subha V Raman; Fiscal Year: 2010
    ..This research tests the theory that monthly loss of iron through menses is protective against atherosclerosis, which could lead to an entirely new approach to preventing and treating heart and vascular disease in both men and women. ..
  12. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. ..
  13. Bridge to neonatal Fontan repair of single ventricle
    Mark Rodefeld; Fiscal Year: 2006
    ..abstract_text> ..
  14. Selective subplate vulnerability and cortical plasticity
    Patrick McQuillen; Fiscal Year: 2007
    ..Finally, we hypothesize that treatments that protect sub-plate neurons in vitro will also prevent sub-plate neuron cell death following early hypoxia ischemia. ..
  15. Cerebrovascular Physiology of Infants with CHD
    Daniel Licht; Fiscal Year: 2007
    ..DOT is complimentary to MRI in that it offers excellent temporal resolution and can be applied at the point of care. Furthermore, DOT offers concurrent analysis of metabolic rate while sacrificing only mild anatomic resolution. ..
  16. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. ..
  17. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  18. Early Neurobiologic Regulation in Infants with Congenital Heart Defects
    Tondi Harrison; Fiscal Year: 2007
    ..This knowledge will be used to develop interventions to assist mothers in establishment of patterns of caregiving supportive of their infant's development. ..
  19. Neurofibromin, Ras & NFAT in Cardiovascular Development
    FRAZ ISMAT; Fiscal Year: 2007
    ..Together this training program will prepare me for independent investigation, lead to a better understanding of cardiovascular abnormalities in neurofibromatosis, and address fundamental issues of cardiovascular development. ..
  20. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  21. SUBPLATE NEURONS AND EARLY HYPOXIC ISCHEMIC BRAIN INJURY
    Patrick McQuillen; Fiscal Year: 2002
    ....