transposition of great vessels

Summary

Summary: A congenital cardiovascular malformation in which the aorta arises entirely from the right ventricle and the pulmonary artery from the left ventricle, so that the venous return from the peripheral circulation is recirculated by the right ventricle via the aorta to the systemic circulation without being oxygenated in the lungs.

Top Publications

  1. ncbi Risk factors for neo-aortic root enlargement and aortic regurgitation following arterial switch operation
    C J McMahon
    Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Cardiol 25:329-35. 2004
  2. ncbi Late gadolinium enhancement cardiovascular magnetic resonance of the systemic right ventricle in adults with previous atrial redirection surgery for transposition of the great arteries
    Sonya V Babu-Narayan
    Adult Congenital Heart Unit, Royal Brompton Hospital, London, UK
    Circulation 111:2091-8. 2005
  3. ncbi Transposition of the great arteries
    Carole A Warnes
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 114:2699-709. 2006
  4. ncbi Pediatric coronary artery bypass for Kawasaki congenital, post arterial switch, and iatrogenic lesions
    C Mavroudis
    Department of Cardiovascular Surgery, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Ann Thorac Surg 68:506-12. 1999
  5. ncbi Heart failure and ventricular dysfunction in patients with single or systemic right ventricles
    Sanaz Piran
    Congenital Cardiac Centre for Adults, Toronto General Hospital, University Health Network, University of Toronto, University of Toronto, Canada
    Circulation 105:1189-94. 2002
  6. ncbi Excessive right ventricular hypertrophic response in adults with the mustard procedure for transposition of the great arteries
    Tim S Hornung
    Adult Congenital Heart Programme, Department of Cardiology, London, United Kingdom
    Am J Cardiol 90:800-3. 2002
  7. doi Ventilatory efficiency and aerobic capacity predict event-free survival in adults with atrial repair for complete transposition of the great arteries
    Alessandro Giardini
    University of Bologna, Italy
    J Am Coll Cardiol 53:1548-55. 2009
  8. ncbi Relation between right ventricular structural alterations and markers of adverse clinical outcome in adults with systemic right ventricle and either congenital complete (after Senning operation) or congenitally corrected transposition of the great arterie
    Alessandro Giardini
    Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Bologna, Italy
    Am J Cardiol 98:1277-82. 2006
  9. ncbi Bridge to transplantation with a left ventricular assist device for systemic ventricular failure after Mustard procedure
    Robert S George
    Department of Transplantation and Mechanical Circulatory, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, United Kingdom
    Ann Thorac Surg 83:306-8. 2007
  10. ncbi Outcomes of 829 neonates with complete transposition of the great arteries 12-17 years after repair
    William G Williams
    Congenital Heart Surgeons Society Data Center, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Eur J Cardiothorac Surg 24:1-9; discussion 9-10. 2003

Detail Information

Publications203 found, 100 shown here

  1. ncbi Risk factors for neo-aortic root enlargement and aortic regurgitation following arterial switch operation
    C J McMahon
    Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Cardiol 25:329-35. 2004
    ..Surgical intervention for AR was rare (2%), however, serial surveillance of such patients is vital to monitor for neo-aortic root enlargement and potential aortic valve dysfunction...
  2. ncbi Late gadolinium enhancement cardiovascular magnetic resonance of the systemic right ventricle in adults with previous atrial redirection surgery for transposition of the great arteries
    Sonya V Babu-Narayan
    Adult Congenital Heart Unit, Royal Brompton Hospital, London, UK
    Circulation 111:2091-8. 2005
    ..Myocardial fibrosis can be visualized by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). We hypothesized that LGE would be present in the systemic RV and relate to adverse clinical features...
  3. ncbi Transposition of the great arteries
    Carole A Warnes
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 114:2699-709. 2006
    ..All patients should be seen periodically in a center where expertise in the clinical evaluation, imaging, and hemodynamic assessment of adult congenital heart disease is available...
  4. ncbi Pediatric coronary artery bypass for Kawasaki congenital, post arterial switch, and iatrogenic lesions
    C Mavroudis
    Department of Cardiovascular Surgery, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Ann Thorac Surg 68:506-12. 1999
    ..Pediatric coronary artery bypass (PCAB) has been recently employed for expanding indications to treat acquired, congenital, post arterial switch, and other iatrogenic pediatric coronary artery problems...
  5. ncbi Heart failure and ventricular dysfunction in patients with single or systemic right ventricles
    Sanaz Piran
    Congenital Cardiac Centre for Adults, Toronto General Hospital, University Health Network, University of Toronto, University of Toronto, Canada
    Circulation 105:1189-94. 2002
    ..Previous studies suggested a high incidence of congestive heart failure in patients with single and/or systemic right ventricles. The corresponding risk in an adult population is unknown...
  6. ncbi Excessive right ventricular hypertrophic response in adults with the mustard procedure for transposition of the great arteries
    Tim S Hornung
    Adult Congenital Heart Programme, Department of Cardiology, London, United Kingdom
    Am J Cardiol 90:800-3. 2002
  7. doi Ventilatory efficiency and aerobic capacity predict event-free survival in adults with atrial repair for complete transposition of the great arteries
    Alessandro Giardini
    University of Bologna, Italy
    J Am Coll Cardiol 53:1548-55. 2009
    ..The goal of this study was to assess the prognostic value of the cardiopulmonary exercise test (CPET) in patients who received a Mustard and Senning (M/S) operation...
  8. ncbi Relation between right ventricular structural alterations and markers of adverse clinical outcome in adults with systemic right ventricle and either congenital complete (after Senning operation) or congenitally corrected transposition of the great arterie
    Alessandro Giardini
    Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Bologna, Italy
    Am J Cardiol 98:1277-82. 2006
    ..The presence of abnormal myocardial regions is associated with RV dysfunction, poor exercise tolerance, arrhythmia, and progressive clinical deterioration...
  9. ncbi Bridge to transplantation with a left ventricular assist device for systemic ventricular failure after Mustard procedure
    Robert S George
    Department of Transplantation and Mechanical Circulatory, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, United Kingdom
    Ann Thorac Surg 83:306-8. 2007
    ..The specific problems are discussed and a management scheme is proposed...
  10. ncbi Outcomes of 829 neonates with complete transposition of the great arteries 12-17 years after repair
    William G Williams
    Congenital Heart Surgeons Society Data Center, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Eur J Cardiothorac Surg 24:1-9; discussion 9-10. 2003
    ..We sought to examine the intermediate outcomes and their associated risk factors in neonates repaired during the era of transition...
  11. doi Declining aerobic capacity of patients with arterial and atrial switch procedures
    Per Morten Fredriksen
    Division of Rehabilitation, Department of Cardiology, Rikshospitalet University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway
    Pediatr Cardiol 30:166-71. 2009
    ..This study aimed to compare exercise data for patients with the two surgical methods...
  12. doi Long-term follow-up of arterial switch operation with an emphasis on function and dimensions of left ventricle and aorta
    Kristof D H M Vandekerckhove
    Department of Pediatric Cardiology and Cardiac Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Cardiothorac Surg 35:582-7; discussion 587-8. 2009
    ..To analyze size and function of aortic root and left ventricle as well as quality of life in patients 20 years after arterial switch procedure...
  13. ncbi Coronary arterial size late after the atrial inversion procedure for transposition of the great arteries: implications for the arterial switch operation
    Z Amin
    Division of Pediatric Cardiology, Medical College of Georgia, Augusta, GA, USA
    J Thorac Cardiovasc Surg 120:1047-52. 2000
    ..We hypothesized that the dimensions of the coronary arteries may correlate with symptomatic status after atrial inversion and may be an important factor when these patients are considered for the arterial switch operation...
  14. ncbi Long-term assessment and serial evaluation of cardiorespiratory exercise performance and cardiac function in patients with atrial switch operation for complete transposition
    T Reybrouck
    Department of Congenital and Paediatric Cardiology, University Hospital Gasthuisberg, Leuven, Belgium
    Cardiol Young 11:17-24. 2001
    ..Serial exercise testing appears useful, because in individual patients in the present study, a decreasing exercise tolerance correlated with development of haemodynamic sequels...
  15. ncbi Intention-to-treat analysis of pulmonary artery banding in conditions with a morphological right ventricle in the systemic circulation with a view to anatomic biventricular repair
    David S Winlaw
    Diana, Princess of Wales Children s Hospital, Birmingham Children s Hospital NHS Trust, Birmingham, England
    Circulation 111:405-11. 2005
    ..They may be eligible for anatomic repair (correction of atrioventricular and ventriculoarterial discordance) but require prior training of the morphological left ventricle (mLV)...
  16. doi Comparison between transthoracic echocardiography and cardiac magnetic resonance imaging in patients status post atrial switch procedure
    Jason G Ho
    Section of Pediatric Cardiology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Congenit Heart Dis 7:122-30. 2012
    ....
  17. doi Diastolic ventricular interaction in patients after atrial switch for transposition of the great arteries: a speckle tracking echocardiographic study
    Pak Cheong Chow
    Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital 102 Pokfulam Road, Hong Kong, China
    Int J Cardiol 152:28-34. 2011
    ..We tested the hypothesis that diastolic ventricular interaction occurs after atrial switch operation for transposition of the great arteries (TGA) and that subpulmonary LV diastolic function is influenced by septal geometry...
  18. doi Late outcome of 132 Senning procedures after 20 years of follow-up
    Francois Roubertie
    Department of Cardiovascular Surgery, Bordeaux Heart University Hospital, University of Bordeaux II, Bordeaux, France
    Ann Thorac Surg 92:2206-13; discussion 2213-4. 2011
    ..Risk factors and rates of reoperation, arrhythmias, systemic right ventricular dysfunction (RVD), and late death after a Senning procedure were investigated...
  19. ncbi The relationship of systemic right ventricular function to ECG parameters and NT-proBNP levels in adults with transposition of the great arteries late after Senning or Mustard surgery
    Carla M Plymen
    The Division of Adult Congenital Heart Disease, The Heart Hospital, University CollegeLondon Hospitals NHS Foundation Trust, London, UK
    Heart 96:1569-73. 2010
    ..The interrelationships between these heart failure markers were examined in adults late after Mustard and Senning surgery...
  20. pmc Transposition of the great arteries
    Paula Martins
    Serviço de Cardiologia Pediátrica, Hospital Pediátrico de Coimbra, Coimbra, Portugal
    Orphanet J Rare Dis 3:27. 2008
    ..However, the exercise performance, cognitive function and quality of life may be impaired...
  21. ncbi New two-dimensional global longitudinal strain and strain rate imaging for assessment of systemic right ventricular function
    P C Chow
    Department of Paediatrics and Adolescent Medicine, Division of Paediatric Cardiology, Grantham Hospital, The University of Hong Kong, 125 Wong Chuk Hang Road, Hong Kong, China
    Heart 94:855-9. 2008
    ..To determine the usefulness of new two-dimensional strain indices, based on speckle tracking imaging, for assessment of systemic right ventricular (RV) function after an atrial switch operation for transposition of the great arteries...
  22. ncbi In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning
    Roselien Buys
    Research Centre for Cardiovascular and Respiratory Rehabilitation, Department of Rehabilitation Sciences, Catholic University of Leuven, Heverlee, Belgium
    Acta Cardiol 67:49-57. 2012
    ..The aim of the study was to come to a better understanding of the interrelationships between determinants of exercise capacity, physical activity and self-perceived health status...
  23. doi Stenosis of the superior limb of the systemic venous baffle following a Mustard procedure: an under-recognized problem
    Natalie A Bottega
    Toronto Congenital Cardiac Centre for Adults, Division of Cardiology, University of Toronto, University Health Network, Toronto General Hospital, Peter Munk Cardiac Centre, Toronto, Ontario, Canada
    Int J Cardiol 154:32-7. 2012
    ..The frequency of this complication in an adult cohort was evaluated...
  24. doi [Preoperative and postoperative imaging in patients with transposition of the great arteries]
    M Gutberlet
    Universitatsklinikum Leipzig, Strümpellstr 39, 04289, Leipzig, Deutschland
    Radiologe 51:15-22. 2011
    ..Multidetector computed tomography (MDCT) is used if there are contraindications to MRI or if an assessment of cardiac and especially coronary anatomy is the main interest...
  25. ncbi Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides
    C A Loffredo
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Epidemiol 153:529-36. 2001
    ..6). No data were collected on specific chemicals or brand names. These results raise new questions about the possible epidemiologic association of TGA with some classes of pesticides and warrant new, carefully targeted investigations...
  26. ncbi Population-based study of l-transposition of the great arteries: possible associations with environmental factors
    Karen S Kuehl
    Department of Cardiology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    Birth Defects Res A Clin Mol Teratol 67:162-7. 2003
    ..L-transposition of the great arteries (l-tga) is an uncommon congenital cardiovascular malformation that occurs from abnormal looping of the primitive cardiac tube. Little is known about risk factors for the development of l-tga...
  27. ncbi Anatomical risk factors for mortality and cardiac morbidity after arterial switch operation
    S H Daebritz
    Department of Thoracic and Cardiovascular Surgery, University Hospital RWTH, Aachen, Germany
    Ann Thorac Surg 69:1880-6. 2000
    ..The arterial switch operation (ASO) is the treatment of choice for transposition of the great arteries...
  28. pmc Current expectations for newborns undergoing the arterial switch operation
    Daniel J Dibardino
    Division of Congenital Heart Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine and Texas Children s Hospital, 6621 Fannin Street, Houston, TX 77030, USA
    Ann Surg 239:588-96; discussion 596-8. 2004
    ..This study is designed to assess recent outcomes after the ASO in babies presenting with transposition of the great arteries (TGA) and Taussig-Bing anomaly (TBA)...
  29. ncbi Right ventricular dysfunction in congenitally corrected transposition of the great arteries
    T S Hornung
    Adolph Basser Cardiac Institute, Department of Nuclear Medicine, Royal Alexandra Hospital for Children, Sydney, Australia
    Am J Cardiol 84:1116-9, A10. 1999
    ..6 +/- 2.3 of a total of 12 segments; the extent of the resting perfusion defects correlated inversely with the RV ejection fraction...
  30. pmc Long term outcome up to 30 years after the Mustard or Senning operation: a nationwide multicentre study in Belgium
    P Moons
    Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Heart 90:307-13. 2004
    ..To assess long term outcome of patients who underwent Mustard or Senning repair for transposition of the great arteries up to 30 years earlier...
  31. ncbi Decline in ventricular function and clinical condition after Mustard repair for transposition of the great arteries (a prospective study of 22-29 years)
    J W Roos-Hesselink
    Department of Cardiology, Thoraxcenter, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur Heart J 25:1264-70. 2004
    ..A prospective study was made to examine long-term survival, clinical outcome, and right ventricular function 25 years after surgery...
  32. pmc Atrioventricular and ventriculoarterial discordance (congenitally corrected transposition of the great arteries): echocardiographic features, associations, and outcome in 34 fetuses
    G Sharland
    Guy s and St Thomas Foundation Trust, London, UK
    Heart 91:1453-8. 2005
    ..To identify fetal echocardiographic features, associations, and outcome of atrioventricular and ventriculoarterial discordance...
  33. ncbi Noncardiac malformations in congenital heart disease: a retrospective analysis of 305 pediatric autopsies
    Safak Gucer
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 47:159-66. 2005
    ..Proper identification and treatment of CHD early in the prenatal period will save the family from the economic and emotional burden caused by having such a child with CHD...
  34. ncbi Long-term outcome in congenitally corrected transposition of the great arteries: a multi-institutional study
    T P Graham
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 2572, USA
    J Am Coll Cardiol 36:255-61. 2000
    ..The purpose of this study was to determine long-term outcome in adults with congenitally corrected transposition of the great arteries (CCTGA), with particular emphasis on systemic ventricular dysfunction and congestive heart failure (CHF)...
  35. ncbi Complete transposition of the great arteries: patterns of congenital heart disease in familial precurrence
    M C Digilio
    Departments of Medical Genetics and Pediatric Cardiology, , Rome
    Circulation 104:2809-14. 2001
    ....
  36. pmc Late arrhythmia in adults with the mustard procedure for transposition of great arteries: a surrogate marker for right ventricular dysfunction?
    M A Gatzoulis
    University of Toronto, Congenital Cardiac Centre for Adults, The Toronto Hospital Department of Medicine, Ontario, Canada
    Heart 84:409-15. 2000
    ..To examine the relation between ventricular dysfunction and late clinical arrhythmia in adults who underwent the Mustard procedure for transposition of the great arteries...
  37. ncbi Long-term survival and functional follow-up in patients after the arterial switch operation
    F Haas
    Department of Cardiovascular Surgery, German Heart Center of Munich
    Ann Thorac Surg 68:1692-7. 1999
    ..For many years, the arterial switch operation (ASO) has been the therapy of choice for patients with transposition of the great arteries (TGA). Although excellent short- and mid-term results were reported, long-term results are rare...
  38. ncbi Progressive tricuspid valve disease in patients with congenitally corrected transposition of the great arteries
    L R Prieto
    Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Circulation 98:997-1005. 1998
    ..The relative importance of these factors in long-term outcome has not been evaluated...
  39. ncbi Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries)
    Nadja Muncke
    Institut fur Humangenetik, Universitat Heidelberg, Heidelberg, Germany
    Circulation 108:2843-50. 2003
    ..TGA represents a septation defect of the common outflow tract of the heart, manifesting around the fifth week during embryonic development. Despite its high prevalence, very little is known about the pathogenesis of this disease...
  40. ncbi Results of the double switch operation for congenitally corrected transposition of the great arteries
    Brian W Duncan
    Pediatric and Congenital Heart Surgery, The Children s Hospital at the Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA
    Eur J Cardiothorac Surg 24:11-9; discussion 19-20. 2003
    ..To determine the outcomes for a program that utilizes the double switch operation as the primary approach for congenitally corrected transposition...
  41. ncbi Neonatal death due to transposition in association with premature closure of the oval foramen
    Michael Ashworth
    Department of Paediatric Histopathology, Great Ormond Street Hospital, London, UK
    Cardiol Young 16:586-9. 2006
    ..Premature closure of the oval foramen is rare in the setting of transposition. As far as we know, there have been only three previously reported cases...
  42. ncbi Midterm results after restoration of the morphologically left ventricle to the systemic circulation in patients with congenitally corrected transposition of the great arteries
    Stephen M Langley
    Department of Cardiac Surgery, Diana Princess of Wales Children s Hospital, Birmingham, United Kingdom
    J Thorac Cardiovasc Surg 125:1229-41. 2003
    ..This study was undertaken to determine the outcomes of patients with congenitally corrected transposition of the great arteries after restoration of the morphologically left ventricle to the systemic circulation...
  43. pmc Late outcome of Senning and Mustard procedures for correction of transposition of the great arteries
    L Dos
    Department of General Cardiology, Hospital Materno Infantil Vall d Hebron, Barcelona, Spain
    Heart 91:652-6. 2005
    ..To evaluate late mortality and morbidity after an atrial switch procedure for correction of transposition of the great arteries (TGA) and to assess predictive factors for adverse outcome...
  44. doi Extending the surgical boundaries in the management of the left ventricular outflow tract obstruction in discordant ventriculo-arterial connections--a surgical and morphological study
    Paula Martins
    Paediatric Cardiology Department, Paediatric Hospital of Coimbra, Portugal
    Cardiol Young 18:124-34. 2008
    ..In this review, we assess all these surgical and anatomic aspects, focussing on their relative importance in clinical assessment...
  45. ncbi Congenital Heart Surgery Nomenclature and Database Project: transposition of the great arteries
    J J Jaggers
    Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 69:S205-35. 2000
    ..These data can lay the foundation for comprehensive risk stratification analyses. A minimum database set is also presented which will allow for data sharing and would lend itself to basic interpretation of trends...
  46. ncbi X-linked transposition of the great arteries and incomplete penetrance among males with a nonsense mutation in ZIC3
    A Megarbane
    Unite de Genetique Medicale, Faculte de Medecine, Université Saint Joseph, Beirut
    Eur J Hum Genet 8:704-8. 2000
    ..To our knowledge, this is the first instance of incomplete penetrance in a male for a mutation in a chromosome X gene...
  47. ncbi Follow-up outcomes 10 years after arterial switch operation for transposition of the great arteries: comparison of cardiological health status and health-related quality of life to those of the a normal reference population
    Wilfred B de Koning
    Department of Paediatrics Division of Cardiology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Pediatr 167:995-1004. 2008
    ..Aortic root dilatation is frequent, irrespective of the anatomical subgroup. Severe aortic regurgitation or left ventricular dilatation was not found. The unfavourable health-related quality of life deserves further attention...
  48. ncbi Catheter management of occluded superior baffle after atrial switch procedures for transposition of great vessels
    Makram R Ebeid
    Department of Pediatrics Cardiology, The University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Cardiol 95:782-6. 2005
    ..Additionally, we report the regression of multiple systemic-to-pulmonary venous fistulas that developed as a result of the occluded baffle...
  49. ncbi Twenty-five-year experience with rastelli repair for transposition of the great arteries
    C Kreutzer
    Departments of Cardiology and Cardiac Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 120:211-23. 2000
    ..Our purpose was to describe the outcome of the Rastelli repair in D -transposition of the great arteries and to determine the risk factors associated with unfavorable events...
  50. ncbi A multiple retinoic acid antagonist induces conotruncal anomalies, including transposition of the great arteries, in mice
    Daria Cipollone
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, 00173 Rome, Italy
    Cardiovasc Pathol 15:194-202. 2006
    ..The aim of the present study was to test the effect of BMS-189453, a retinoic acid antagonist, on murine heart morphogenesis...
  51. ncbi Outcomes of definitive surgical repair for congenitally corrected transposition of the great arteries or double outlet right ventricle with discordant atrioventricular connections: risk analyses in 189 patients
    Toshiharu Shin'oka
    Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    J Thorac Cardiovasc Surg 133:1318-28, 1328.e1-4. 2007
    ....
  52. ncbi Repair of transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction
    Jeong Ryul Lee
    Department of Thoracic and Cardiovascular Surgery, Seoul National University Children s Hospital, Seoul National University College of Medicine, Seoul National University Medical Research Center, Jongro Gu, Seoul 110 744, South Korea
    Eur J Cardiothorac Surg 25:735-41. 2004
    ....
  53. ncbi Detection of transposition of the great arteries in fetuses reduces neonatal morbidity and mortality
    D Bonnet
    Service de Cardiologie Pediatrique, Hopital Necker Enfants Malades, Paris, France
    Circulation 99:916-8. 1999
    ..Transposition of the great arteries (TGA) is a life-threatening malformation in neonates, but it is amenable to complete repair. Prenatal detection, diagnosis, and early management may modify neonatal mortality and mortality...
  54. ncbi Double switch for congenitally corrected transposition of the great arteries
    R Sharma
    Cardio Thoracic Centre, All India Institute of Medical Sciences, New Delhi
    Eur J Cardiothorac Surg 15:276-81; discussion 281-2. 1999
    ..To evaluate the early and medium term results of operations for congenitally corrected transposition of the great arteries (CCTGA) wherein the left ventricle becomes the systemic ventricle...
  55. ncbi Aortic translocation in the management of transposition of the great arteries with ventricular septal defect and pulmonary stenosis: results and follow-up
    Victor O Morell
    Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann Thorac Surg 79:2089-92; discussion 2092-3. 2005
    ..The objective in this retrospective study was to review our experience using aortic translocation and biventricular outflow tract reconstruction as an alternative surgical procedure for the management of these patients...
  56. ncbi Sequential diagnosis of coronary arterial anatomy in congenitally corrected transposition of the great arteries
    Ing Sh Chiu
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Ann Thorac Surg 75:422-9; discussion 429. 2003
    ..Precise CA anatomy is surgically needed in the current era of double switch for CCT...
  57. ncbi [Transposition of great arteries. Understanding its pathogenesis]
    Bruno Marino
    Cattedra di Cardiologia Pediatrica Istituto di Pediatria Università degli Studi La Sapienza Viale Regina Elena, 324 00161 Roma
    Ital Heart J Suppl 3:154-60. 2002
    ..The mystery is still present but perhaps some gleams of light are appearing...
  58. doi Familial transposition of the great arteries caused by multiple mutations in laterality genes
    Alessandro De Luca
    Mendel Laboratory, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Heart 96:673-7. 2010
    ..In general, TGA is not associated with the more common genetic disorders nor with extracardiac anomalies, whereas it can be found in individuals with lateralisation defects, heterotaxy and asplenia syndrome (right isomerism)...
  59. doi Anatomic repair for congenitally corrected transposition of the great arteries
    Rajesh Sharma
    Narayana Hrudayalaya Institute of Cardiac Sciences, Bangalore, India
    J Thorac Cardiovasc Surg 137:404-412.e4. 2009
    ..Anatomic repair is being actively evaluated as the preferred option for congenitally corrected transposition of the great arteries. We present our 13-year experience with this approach...
  60. ncbi Long-term outcome of surgically treated patients with corrected transposition of the great arteries
    Viktor Hraska
    Department of Pediatric Cardiac Surgery, University Hospital Hamburg Eppendorf, Germany
    J Thorac Cardiovasc Surg 129:182-91. 2005
    ....
  61. ncbi Two-stage arterial switch operation: is late ever too late?
    Howaida O Al Qethamy
    Department of Cardiac Surgery Prince Sultan Cardiac Centre Riyadh Military Hospital Riyadh, Saudi Arabia
    Asian Cardiovasc Thorac Ann 10:235-9. 2002
    ....
  62. ncbi Intermediate results of the anatomic repair for congenitally corrected transposition
    Michel N Ilbawi
    University of Illinois at Chicago, The Heart Institute for Children, Hope Children s Hospital, Oak Lawn, Illinois 60453, USA
    Ann Thorac Surg 73:594-9; discussion 599-600. 2002
    ..Anatomic repair of congenitally corrected transposition of the great arteries has several advantages over the traditional approach but lacks long-term evaluation...
  63. pmc CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle
    Elizabeth Goldmuntz
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Hum Genet 70:776-80. 2002
    ..In addition, these results demonstrate that the molecular pathway involving CFC1 plays a critical role in normal and abnormal cardiovascular development...
  64. ncbi Outcome of 121 patients with congenitally corrected transposition of the great arteries
    J M Rutledge
    Department of Pediatrics, Texas Children s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Cardiol 23:137-45. 2002
    ..We support a move toward an alternative surgical approach (double switch procedure) in carefully selected patients...
  65. ncbi Preoperative identification of coronary arterial anatomy in complete transposition, and outcome after the arterial switch operation
    Colin J McMahon
    Section of Pediatric Cardiology, Division of Congenital Heart Surgery, LillieFrank Abercrombie Division of Pediatric Cardiology, Texas Children s Hospital, 6621 Fannin, Houston, Texas 77030, USA
    Cardiol Young 12:240-7. 2002
    ..Perceived correlation between the coronary arterial anatomy in patients with complete transposition, and the outcome of the arterial switch procedure, has made preoperative identification of their patterns standard practice...
  66. ncbi Early and late results of operations for defects associated with corrected transposition and other anomalies with atrioventricular discordance in a pediatric population
    G Biliciler-Denktas
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA
    J Thorac Cardiovasc Surg 122:234-41. 2001
    ..CONCLUSIONS: These results can serve as a basis for comparison with newer surgical alternatives proposed for corrected transposition of the great arteries...
  67. ncbi Surgical management and indication of left ventricular retraining in arterial switch for transposition of the great arteries with intact ventricular septum
    F Lacour-Gayet
    Marie Lannelongue Hospital, Paris Sud University, 133 avenue de la Resistance, 92350 Le Plessis Robinson, Paris, France
    Eur J Cardiothorac Surg 20:824-9. 2001
    ..In cases of late referral, perinatal complications or early left ventricular (LV) dysfunction, the one stage arterial switch is contra indicated. Anatomical repair remains possible in these patients following a LV retraining...
  68. doi Late reoperations after neonatal arterial switch operation for transposition of the great arteries
    Emanuela Angeli
    Department of Pediatric Cardiac Surgery, University Paris Descartes and Sick Children Hospital, Paris, France
    Eur J Cardiothorac Surg 34:32-6. 2008
    ..Left ventricular function is maintained in the vast majority of patients. Reoperation may be indicated in some patients for other reasons: mitral valve malformation, tracheo-bronchial compression or pulmonary hypertension...
  69. ncbi Technical aspects of the Rastelli and atrial switch procedure for congenitally corrected transposition of the great arteries with ventricular septal defect and pulmonary stenosis or atresia: results of therapy
    William J Brawn
    Birmingham s Children s Hospital NHS Trust, Diana, Princess of Wales Children s Hospital, Birmingham, UK
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 6:4-8. 2003
    ..A disadvantage is that these patients require valved conduit changes over the years...
  70. ncbi The morphologic left ventricle that requires training by means of pulmonary artery banding before the double-switch procedure for congenitally corrected transposition of the great arteries is at risk of late dysfunction
    David W Quinn
    Department of Cardiac Surgery, Birmingham Children s Hospital NHS Trust, Birmingham, United Kingdom
    J Thorac Cardiovasc Surg 135:1137-44, 1144.e1-2. 2008
    ....
  71. ncbi Newborn patients exhibit an unusual pattern of interleukin 10 and interferon gamma serum levels in response to cardiac surgery
    A J Alcaraz
    Department of Pediatrics and Pediatric Surgery, Pediatric Intensive Care Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Thorac Cardiovasc Surg 123:451-8. 2002
    ..The aim of this study was to determine the clinical significance of serum levels of interleukin 10 and interferon gamma in pediatric patients undergoing cardiopulmonary bypass...
  72. ncbi Late outcome after arterial switch operation for transposition of the great arteries
    J Losay
    Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
    Circulation 104:I121-6. 2001
    ..Early and midterm results of the arterial switch operation (ASO) in transposition of the great arteries (TGA) are good, but late outcome data in large populations are still few...
  73. ncbi Production of proinflammatory cytokines and myocardial dysfunction after arterial switch operation in neonates with transposition of the great arteries
    Hedwig H Hövels-Gürich
    Department of Pediatric Cardiology, Institute of Biomedical Statistics, Aachen University of Technology, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Thorac Cardiovasc Surg 124:811-20. 2002
    ..The purpose of this study was to test the hypothesis that the production of proinflammatory cytokines during cardiac surgery would be associated with myocardial dysfunction after the arterial switch operation in neonates...
  74. ncbi En bloc rotation of the truncus arteriosus--an option for anatomic repair of transposition of the great arteries, ventricular septal defect, and left ventricular outflow tract obstruction
    Rudolf Mair
    Department of Cardiac Surgery, General Hospital Linz, Austria
    J Thorac Cardiovasc Surg 131:740-1. 2006
  75. ncbi Prevalence of arrhythmias and their risk factors mid- and long-term after the arterial switch operation
    George Hayashi
    Department of Pediatrics, Shimane University School of Medicine, 89 1, Enya cho, Izumo City, Shimane, 693 8501, Japan
    Pediatr Cardiol 27:689-94. 2006
    ..VSD was a risk factor for postoperative arrhythmia, especially CAVB. Approximately half of the arrhythmias developed late. Lifelong monitoring with respect to arrhythmia is needed for patients after ASO...
  76. ncbi Primary surgical correction of transposition of the great arteries and atrioventricular septal defect associated with left isomerism
    S Kikuchi
    Department of Cardiovascular Surgery, Hokkaido Children s Hospital and Medical Center, Zenibako 1 10 1 Otaru, Hokkaido, 047 0261, Japan
    Pediatr Cardiol 27:124-7. 2006
    ..To the best of our knowledge, this is the first report of successful primary surgical repair of TGA and AVSD with left isomerism. Primary anatomic correction of this defect combination is feasible in patients with left isomerism...
  77. ncbi Unusual and early hyperglycemia following amiodarone infusion in two infants
    S V Yildirim
    Division of Pediatric Cardiology, Baskent University, Faculty of Medicine, Ankara, Turkey
    Pediatr Cardiol 26:715-6. 2005
    ..We present two infants who had hyperglycemia following amiodarone infusion during the early postoperative period...
  78. ncbi Arterial switch operation for transposition of the great arteries combined with closure of paramembranous ventricular septal defect using the Amplatzer membranous ventricular septal occluder
    Hakan Akintuerk
    Pediatric Heart Center, Justus Liebig University, Giessen, Germany
    Am J Cardiol 96:592-4. 2005
    ..The cardiac arrest time for anatomic repair might be effectively reduced by this new approach in pediatric cardiac surgery...
  79. ncbi Mid-term follow-up of neoaortic regurgitation after the arterial switch operation for transposition of the great arteries
    Ho Young Hwang
    Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, Seoul National University, College of Medicine, Seoul National University Children s Hospital, 28 Yongon Dong, Jongro Gu, Seoul 110 744, South Korea
    Eur J Cardiothorac Surg 29:162-7. 2006
    ..The aim of this study was to determine the outcome of the neoaortic valve after the arterial switch operation for transposition of the great arteries...
  80. ncbi Valved bovine jugular vein conduits for right ventricular outflow tract reconstruction in children: an attractive alternative to pulmonary homograft
    John W Brown
    Section of Cardiothoracic Surgery, James W Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202 5123, USA
    Ann Thorac Surg 82:909-16. 2006
    ..Recently a valve-containing bovine jugular vein (Contegra, Medtronic, Inc, Minneapolis, MN) was introduced for clinical trials for a variety of patients requiring RVOT reconstruction...
  81. ncbi Surgical results of arterial switch operation for Taussig-Bing anomaly: is position of the great arteries a risk factor?
    Mark D Rodefeld
    Section of Cardiothoracic Surgery, James W Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, Indiana 46202 5123, USA
    Ann Thorac Surg 83:1451-7. 2007
    ..This study identifies the impact of the position of the great arteries and use of a staged surgical approach on the outcome after the arterial switch operation in children with Taussig-Bing anomaly...
  82. ncbi Serum cardiac troponin-I elevation in neonatal cardiac surgery is lesion-dependent
    Neeta R Saraiya
    Department of Anesthesiology, Columbia University, New York, NY 10032, USA
    J Cardiothorac Vasc Anesth 19:620-5. 2005
    ....
  83. ncbi Chromosome 22q11 deletions in patients with conotruncal heart defects
    A Khositseth
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
    Pediatr Cardiol 26:570-3. 2005
    ..A subgroup of patients with IAA, TA, SPVSD, and PAVSD associated with phenotypic features or abnormalities warrants evaluation for the presence of 22q11 deletions...
  84. ncbi Is preoperative delineation of coronary artery pattern a prerequisite for arterial switch operation?
    Ghassan M Baslaim
    Division of Cardiothoracic Surgery, Department of Cardiovascular Diseases, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
    J Card Surg 21:465-70. 2006
    ..To determine the effect of preoperative echocardiographic delineation of coronary artery pattern on the immediate postoperative result of arterial switch procedures...
  85. ncbi Postoperative prophylactic peritoneal dialysis in neonates and infants after complex congenital cardiac surgery
    Tijen Alkan
    V K V American Hospital, Department of Cardiovascular Surgery, Istanbul, Turkey
    ASAIO J 52:693-7. 2006
    ....
  86. ncbi [Double outlet left ventricle: a rare and unusual cardiopathy. Apropos of 7 new cases]
    M Gouton
    , Lyon
    Arch Mal Coeur Vaiss 89:553-9. 1996
    ..The anatomical variability is due to the complex embryogenesis of the conotruncal region and explains the clinical diversity of this congenital cardiac malformation...
  87. ncbi [Double discordances with ventricular septal defect and pulmonary obstruction. A study of 72 cases]
    P Acar
    , , Paris
    Arch Mal Coeur Vaiss 90:625-9. 1997
    ..Therefore, there is no place for elective surgery in this malformation: when necessary, the best option is to remain palliative as long as possible: when correction is required, an anatomical correction is the best procedure...
  88. ncbi Arterial switch operation: troponin T does not predict ventilation requirements
    Madan M Maddali
    Departments of Anesthesia and Cardiothoracic Surgery, Royal Hospital, Seeb, Muscat, Sultanate of Oman
    Asian Cardiovasc Thorac Ann 16:274-7. 2008
    ..It was concluded that the postoperative cardiac troponin T level is not a predictor of successful extubation or prolonged artificial ventilation in this subset...
  89. ncbi Determinants of right ventricular outflow tract conduit longevity: a multinational analysis
    Marieke B A Niemantsverdriet
    Pediatric Cardiology, Center for Congenital Abnormalities of Heart, Amsterdam Leiden, The Netherlands
    Congenit Heart Dis 3:176-84. 2008
    ..We compared two diverse surgical centers with considerable practice variation in Europe and the United States to identify modifiable risk factors that can increase conduit longevity...
  90. ncbi Predictors of outcome of arterial switch operation for complex D-transposition
    Danielle Gottlieb
    Department of Cardiology and Cardiovascular Surgery, Children s Hospital Boston, Boston, Massachusetts, USA
    Ann Thorac Surg 85:1698-702; discussion 1702-3. 2008
    ..D-TGA with ventricular septal defect (VSD) and aortic arch obstruction (AAO) is a higher risk subgroup in which we sought risk factors for mortality and reoperation after ASO...
  91. ncbi [Long term outcome of arterial switch surgery for transposition of the great arteries: evaluation of the reconstruction of the pulmonary artery]
    Hiroaki Kawata
    Department of Cardiovascular Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan
    Kyobu Geka 61:303-9. 2008
    ....
  92. ncbi [Arterial switch operation: late results and a future perspective]
    Mitsuru Aoki
    Department of Cardiovascular Surgery, Chiba Children s Hospital, Chiba, Japan
    Kyobu Geka 61:268-73. 2008
    ..Risk factors for aortic regurgitation were age at operation and prior PAB. Early primary arterial switch operation may resolve these problems...
  93. doi Long-term outcomes and social independence level after arterial switch operation
    Akira Yamazaki
    Department of Cardiovascular Surgery, Tokyo Women s Medical University, Japan
    Eur J Cardiothorac Surg 33:239-43. 2008
    ..Various issues regarding the long-term survivors of arterial switch operation (ASO) have been clarified according to the improvement of surgical mortality. We reviewed the long-term results and social independence level after ASO...
  94. doi Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery
    Jane W Newburger
    Department of Cardiology, Children s Hospital Boston, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 135:347-54, 354.e1-4. 2008
    ..However, worse outcomes were concentrated in patients with hematocrit values of 20% or below, and the benefits of hematocrit values higher than 25% were uncertain...
  95. ncbi Application of modified perfusion technique on one stage repair of interrupted aortic arch in infants: a case series and literature review
    Jinping Liu
    Department of Cardiopulmonary Bypass, Fuwai Hospital, CAMD and PUMS, Beijing, China
    ASAIO J 53:666-9. 2007
    ....
  96. ncbi Early and mid-term outcome of the arterial switch operation in 114 consecutive patients : A single centre experience
    C Prandstetter
    Department of Peadiatric Cardiology, Children s Heart Centre Linz, Krankenhausstrasse 26 30, 4020 Linz, Austria
    Clin Res Cardiol 96:723-9. 2007
    ..The purpose of this study was to assess early and mid-term outcome after ASO in a single centre...
  97. ncbi The year in congenital heart disease
    Thomas P Graham
    Division of Pediatric Cardiology, Vanderbilt Children s Hospital, Nashville, Tennessee 37232 9119, USA
    J Am Coll Cardiol 50:368-77. 2007
  98. ncbi The optimal procedure for the great arteries and left ventricular outflow tract obstruction. An anatomical study
    Mark Hazekamp
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cardiothorac Surg 31:879-87. 2007
    ..To describe the optimal surgical strategy in heart specimens with transposition of the great arteries (TGA) and left ventricular outflow tract obstruction (LVOTO)...
  99. ncbi Late coronary artery lesions after neonatal arterial switch operation: results of surgical coronary revascularization
    Olivier Raisky
    Department of Pediatric Cardiac Surgery, University Paris Descartes and Sick Children Hospital, Paris, France
    Eur J Cardiothorac Surg 31:894-8. 2007
    ..To evaluate the results of surgical revascularization in children with coronary artery lesions following neonatal arterial switch operation (ASO)...
  100. ncbi State of the art of cardiac surgery in patients with congenital heart disease
    Lucio Zannini
    Division of Pediatric Cardiac Surgery, IRCCS Giannina Gaslini, Genoa, Italy
    J Cardiovasc Med (Hagerstown) 8:3-6. 2007
    ....
  101. ncbi [Systemic pulmonary shunts in the neonatal period. Short and medium-term results]
    A Chantepie
    , , CHU de Tours
    Arch Mal Coeur Vaiss 88:693-8. 1995
    ..Cardiac failure occurred in 83% of group B and 22% of group A (p < 0.01). The probability of shunt efficacy was 89% at 1 year, 63% at 2 years and 45% at 3 years.(ABSTRACT TRUNCATED AT 250 WORDS)..

Research Grants50

  1. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2001
    ..abstract_text> ..
  2. Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)
    David Bellinger; Fiscal Year: 2007
    ..Members of the faculty currently conduct a wealth of multidisciplinary research, which will provide trainees with ready opportunities to apply their training in ongoing research projects. [unreadable] [unreadable]..
  3. Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)
    David Bellinger; Fiscal Year: 2008
    ..Members of the faculty currently conduct a wealth of multidisciplinary research, which will provide trainees with ready opportunities to apply their training in ongoing research projects. [unreadable] [unreadable]..
  4. Cerebral Blood Flow in Single Ventricle and Normal Children Utilizing MRI
    Mark Fogel; Fiscal Year: 2008
    ..Changing the way the blood flows in these patients by surgery may alter the way we ultimately manage these patients medically and surgically. [unreadable] [unreadable] [unreadable]..
  5. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2009
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  6. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2008
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  7. Cerebral Blood Flow in Single Ventricle and Normal Children Utilizing MRI
    MARK ALAN FOGEL; Fiscal Year: 2010
    ..Changing the way the blood flows in these patients by surgery may alter the way we ultimately manage these patients medically and surgically. ..
  8. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2005
    ..abstract_text> ..
  9. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2010
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  10. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2009
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  11. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2002
    ..abstract_text> ..
  12. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2004
    ..abstract_text> ..
  13. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2003
    ..abstract_text> ..
  14. Effects of general vs. regional anesthesia on infant neurodevelopment and apnea
    Mary Ellen McCann; Fiscal Year: 2010
    ..If general and regional awake anesthesia result in neurodevelopmental outcomes that are equivalent, this would support the safety of general anesthetics as currently used. ..
  15. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2008
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
  16. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2007
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
  17. A Novel Approach to Cardiac Replacement with Continuous Flow Pumps
    O Frazier; Fiscal Year: 2008
    ..The availability of an effective, reliable replacement such as the continuous-flow TAH for the failing human heart would thus have an enormous impact on health care. ..
  18. Cerebrovascular Physiology of Infants with CHD
    Daniel Licht; Fiscal Year: 2008
    ..DOT is complimentary to MRI in that it offers excellent temporal resolution and can be applied at the point of care. Furthermore, DOT offers concurrent analysis of metabolic rate while sacrificing only mild anatomic resolution. ..
  19. Neurofibromin, Ras & NFAT in Cardiovascular Development
    FRAZ ISMAT; Fiscal Year: 2007
    ..Together this training program will prepare me for independent investigation, lead to a better understanding of cardiovascular abnormalities in neurofibromatosis, and address fundamental issues of cardiovascular development. ..
  20. Early Neurobiologic Regulation in Infants with Congenital Heart Defects
    Tondi Harrison; Fiscal Year: 2008
    ..This knowledge will be used to develop interventions to assist mothers in establishment of patterns of caregiving supportive of their infant's development. [unreadable] [unreadable] [unreadable]..
  21. Cavopulmonary Assist: Circulatory Support for the Univentricular Fontan Circulat
    Mark D Rodefeld; Fiscal Year: 2010
    ..This will dramatically improve the healthcare of children and adults born with single ventricle heart disease. ..
  22. Selective subplate vulnerability and cortical plasticity
    Patrick McQuillen; Fiscal Year: 2008
    ..Finally, we hypothesize that treatments that protect sub-plate neurons in vitro will also prevent sub-plate neuron cell death following early hypoxia ischemia. [unreadable] [unreadable]..
  23. Iron and Atherosclerosis
    Subha V Raman; Fiscal Year: 2010
    ..This research tests the theory that monthly loss of iron through menses is protective against atherosclerosis, which could lead to an entirely new approach to preventing and treating heart and vascular disease in both men and women. ..
  24. Critical Period Plasticity Following Neonatal Brain Injury
    Patrick McQuillen; Fiscal Year: 2008
    ..Understanding plasticity following injury will provide both a new outcome measure and a model to guide therapy for recovering brain function. ..
  25. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2009
    ..This research tests the theory that monthly loss of iron through menses is protective against atherosclerosis, which could lead to an entirely new approach to preventing and treating heart and vascular disease in both men and women. ..
  26. White Matter Injury in Critical Ill Newborns With Congenital Heart Disease
    Patrick Sean McQuillen; Fiscal Year: 2010
    ..Page McQuillen, Patrick S. ..
  27. White Matter Injury in Critical Ill Newborns With Congenital Heart Disease
    Patrick McQuillen; Fiscal Year: 2009
    ..Page McQuillen, Patrick S. ..
  28. Critical Period Plasticity Following Neonatal Brain Injury
    Patrick Sean McQuillen; Fiscal Year: 2010
    ..Understanding plasticity following injury will provide both a new outcome measure and a model to guide therapy for recovering brain function. ..
  29. Critical Period Plasticity Following Neonatal Brain Injury
    Patrick McQuillen; Fiscal Year: 2009
    ..Understanding plasticity following injury will provide both a new outcome measure and a model to guide therapy for recovering brain function. ..
  30. Neurofibromin, Ras & NFAT in Cardiovascular Development
    FRAZ ISMAT; Fiscal Year: 2008
    ..Together this training program will prepare me for independent investigation, lead to a better understanding of cardiovascular abnormalities in neurofibromatosis, and address fundamental issues of cardiovascular development. ..
  31. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2005
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. ..
  32. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2005
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  33. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2005
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. ..
  34. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2004
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. ..
  35. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2004
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  36. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2004
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. ..
  37. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2003
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  38. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2003
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. ..
  39. Bridge to neonatal Fontan repair of single ventricle
    Mark Rodefeld; Fiscal Year: 2006
    ..abstract_text> ..
  40. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2006
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. [unreadable] [unreadable]..
  41. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  42. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. [unreadable] [unreadable]..
  43. Selective subplate vulnerability and cortical plasticity
    Patrick McQuillen; Fiscal Year: 2007
    ..Finally, we hypothesize that treatments that protect sub-plate neurons in vitro will also prevent sub-plate neuron cell death following early hypoxia ischemia. [unreadable] [unreadable]..
  44. Cerebrovascular Physiology of Infants with CHD
    Daniel Licht; Fiscal Year: 2007
    ..DOT is complimentary to MRI in that it offers excellent temporal resolution and can be applied at the point of care. Furthermore, DOT offers concurrent analysis of metabolic rate while sacrificing only mild anatomic resolution. ..
  45. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. [unreadable] [unreadable]..
  46. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  47. Early Neurobiologic Regulation in Infants with Congenital Heart Defects
    Tondi Harrison; Fiscal Year: 2007
    ..This knowledge will be used to develop interventions to assist mothers in establishment of patterns of caregiving supportive of their infant's development. [unreadable] [unreadable] [unreadable]..
  48. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  49. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2006
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. [unreadable] [unreadable]..
  50. SUBPLATE NEURONS AND EARLY HYPOXIC ISCHEMIC BRAIN INJURY
    Patrick McQuillen; Fiscal Year: 2002
    ....