patent ductus arteriosus

Summary

Summary: Abnormal persistence of an open lumen in the ductus arteriosus after birth, the direction of flow being from the aorta to the pulmonary artery, resulting in recirculation of arterial blood through the lungs. (Dorland, 27th ed)

Top Publications

  1. ncbi The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials
    D B Knight
    Newborn Services, National Women s Hospital, Claude Road, Auckland, New Zealand
    Semin Neonatol 6:63-73. 2001
  2. ncbi Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus
    Limin Zhu
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Département de génétique, 75015 Paris, France
    Nat Genet 38:343-9. 2006
  3. pmc Towards rational management of the patent ductus arteriosus: the need for disease staging
    Patrick J McNamara
    Patrick J McNamara, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
    Arch Dis Child Fetal Neonatal Ed 92:F424-7. 2007
  4. ncbi Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?
    W E Benitz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304 1510, USA
    J Perinatol 30:241-52. 2010
  5. ncbi Patent ductus arteriosus of the preterm infant
    Shannon E G Hamrick
    Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Pediatrics 125:1020-30. 2010
  6. ncbi Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus
    Wenli L Zhu
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China
    Mol Hum Reprod 12:51-4. 2006
  7. ncbi Patent ductus arteriosus in micropreemies and full-term infants: the relative merits of surgical ligation versus indomethacin treatment
    Danny C Little
    Scott and White Hospital, Temple, Texas 76508, USA
    J Pediatr Surg 38:492-6. 2003
  8. pmc Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment
    Nami Jhaveri
    Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
    J Pediatr 157:381-7, 387.e1. 2010
  9. pmc Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion
    Xuesong Feng
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 137:4191-9. 2010
  10. ncbi Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus
    M Satoda
    Departments of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Nat Genet 25:42-6. 2000

Detail Information

Publications239 found, 100 shown here

  1. ncbi The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials
    D B Knight
    Newborn Services, National Women s Hospital, Claude Road, Auckland, New Zealand
    Semin Neonatol 6:63-73. 2001
    b>Patent ductus arteriosus (PDA) is a common problem in very preterm infants. It results in a significant left-to-right shunt and an increase in left ventricular output. Pulmonary compliance can be reduced...
  2. ncbi Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus
    Limin Zhu
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Département de génétique, 75015 Paris, France
    Nat Genet 38:343-9. 2006
    ..recently described two kindreds presenting thoracic aortic aneurysm and/or aortic dissection (TAAD) and patent ductus arteriosus (PDA) and mapped the disease locus to 16p12.2-p13.13 (ref. 3)...
  3. pmc Towards rational management of the patent ductus arteriosus: the need for disease staging
    Patrick J McNamara
    Patrick J McNamara, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
    Arch Dis Child Fetal Neonatal Ed 92:F424-7. 2007
  4. ncbi Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?
    W E Benitz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94304 1510, USA
    J Perinatol 30:241-52. 2010
    Medical and surgical interventions are widely used to close a persistently patent ductus arteriosus in preterm infants. Objective evidence to support these practices is lacking, causing some to question their usage...
  5. ncbi Patent ductus arteriosus of the preterm infant
    Shannon E G Hamrick
    Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Pediatrics 125:1020-30. 2010
    A persistently patent ductus arteriosus (PDA) in preterm infants can have significant clinical consequences, particularly during the recovery period from respiratory distress syndrome...
  6. ncbi Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus
    Wenli L Zhu
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China
    Mol Hum Reprod 12:51-4. 2006
    ..of congenital heart defects (CHDs), 21 patients with atrial septal defect (ASD), 35 patients with patent ductus arteriosus (PDA), one patient with both conditions combined, and their biological parents were collected as the case ..
  7. ncbi Patent ductus arteriosus in micropreemies and full-term infants: the relative merits of surgical ligation versus indomethacin treatment
    Danny C Little
    Scott and White Hospital, Temple, Texas 76508, USA
    J Pediatr Surg 38:492-6. 2003
    ..Treatment of ductus arteriosus is controversial. The merits and timing of ductus ligation versus indomethacin treatment were compared...
  8. pmc Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment
    Nami Jhaveri
    Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
    J Pediatr 157:381-7, 387.e1. 2010
    To examine whether a more conservative approach to treating patent ductus arteriosus (PDA) is associated with an increase or decrease in morbidity compared with an approach involving early PDA ligation.
  9. pmc Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion
    Xuesong Feng
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 137:4191-9. 2010
    ..Failure of the ductus arteriosus to close after birth is termed patent ductus arteriosus and is one of the most common congenital heart defects...
  10. ncbi Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus
    M Satoda
    Departments of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Nat Genet 25:42-6. 2000
    Char syndrome is an autosomal dominant trait characterized by patent ductus arteriosus, facial dysmorphism and hand anomalies...
  11. ncbi Patent ductus arteriosus in very low birthweight infants: complications of pharmacological and surgical treatment
    P S Koehne
    Departments of Neonatology and Pediatric Cardiology, Charite Virchow Hospital, Humboldt University, Department of Cardiovascular Surgery, German Heart Institute Berlin, Germany
    J Perinat Med 29:327-34. 2001
    To evaluate complications of surgical and pharmacological treatment of symptomatic patent ductus arteriosus (PDA) in very low birthweight (VLBW) infants.
  12. ncbi Consequences of delayed surgical closure of patent ductus arteriosus in very premature infants
    Sophie Jaillard
    Service de Chirurgie, Polyclinique du Bois, Lille, France
    Ann Thorac Surg 81:231-4. 2006
    ..The aim of this study was to assess short-term and mid-term effects of delayed surgical closure of the ductus arteriosus on respiratory and digestive outcome in extremely preterm infants...
  13. ncbi Is there an optimal timing for surgical ligation of patent ductus arteriosus in preterm infants?
    Vladimiro L Vida
    Department of Pediatric and Congenital Cardiac Surgery, University of Padua, Padua, Italy
    Ann Thorac Surg 87:1509-15; discussion 1515-6. 2009
    We sought to define the variables associated with hospital outcome in preterm infants with patent ductus arteriosus (PDA) and identify the optimal timing for PDA closure to improve hospital outcome.
  14. ncbi Early versus late indomethacin treatment for patent ductus arteriosus in premature infants with respiratory distress syndrome
    B Van Overmeire
    Department of Paediatrics, Division of Neonatology, University Hospital Antwerpen, Antwerpen, Belgium
    J Pediatr 138:205-11. 2001
    OBJECTIVE: To compare efficacy and side effects of early versus late indomethacin treatment for patent ductus arteriosus (PDA) in premature infants...
  15. ncbi B-type natriuretic peptide concentrations to guide treatment of patent ductus arteriosus
    J T Attridge
    Department of Paediatrics, Division of Neonatology, University of Virginia, Charlottesville, VA 22908, USA
    Arch Dis Child Fetal Neonatal Ed 94:F178-82. 2009
    To determine whether b-type natriuretic peptide (BNP) concentrations can guide treatment of patent ductus arteriosus (PDA) to reduce the number of indomethacin doses without increasing morbidity.
  16. ncbi Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants
    B Schmidt
    Department of Pediatrics, McMaster University, Hamilton, Ont, Canada
    N Engl J Med 344:1966-72. 2001
    The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g)...
  17. ncbi Total serum bilirubin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in preterm infants
    C Rheinlaender
    Department of Neonatology, Charite, Campus Virchow Hospital, University Medicine Berlin, Augustenberger Platz 1, Berlin, Germany
    Acta Paediatr 98:36-42. 2009
    ..To determine whether ibuprofen use in VLBW infants is associated with increased serum bilirubin levels and impaired neurodevelopmental outcome at 2 years of age compared to indomethacin...
  18. ncbi Effect of ibuprofen on bilirubin-albumin binding in vitro at concentrations observed during treatment of patent ductus arteriosus
    C Diot
    SGS Cephac Europe, Saint Benoît Cedex, France
    Early Hum Dev 86:315-7. 2010
    ..In vitro studies have shown that ibuprofen (IBU) may interfere with bilirubin-albumin binding at concentrations of 100 microg/mL and above...
  19. ncbi Echocardiographic predictors of symptomatic patent ductus arteriosus in extremely-low-birth-weight preterm neonates
    F G Ramos
    Division of Cardiology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA
    J Perinatol 30:535-9. 2010
    Identify echocardiographic parameters at <or=4 day postnatal that predict the subsequent need for closure of a clinically significant patent ductus arteriosus (sPDA) in extremely-low-birth-weight neonates (ELBW).
  20. pmc Is surgical ligation of patent ductus arteriosus necessary? The Western Australian experience of conservative management
    J M Brooks
    Women s and Children s Health Service, Western Australia
    Arch Dis Child Fetal Neonatal Ed 90:F235-9. 2005
    Surgical ligation of patent ductus arteriosus (PDA) is widely practised in preterm infants despite no clear evidence that this improves outcomes...
  21. ncbi Patent ductus arteriosus ligation in premature infants: who really benefits, and at what cost?
    Mehul V Raval
    Division of Pediatric Surgery, Department of Surgery, University of North Carolina at Chapel Hill, NC 27599 7223, USA
    J Pediatr Surg 42:69-75; discussion 75. 2007
    b>Patent ductus arteriosus (PDA) ligation in premature infants has been shown to have low surgical morbidity and mortality...
  22. ncbi Diagnosis of patent ductus arteriosus
    J Skinner
    Department of Paediatrics, Green Lane Hospital, Green Lane West, Auckland, New Zealand
    Semin Neonatol 6:49-61. 2001
    ..The neonatal clinician and echocardiographer is reminded to remain wary of occult congenital heart disease, particularly before closing the ductus...
  23. ncbi Novel TFAP2B mutation in nonsyndromic patent ductus arteriosus
    Maher Khetyar
    Division of Clinical Developmental Sciences, St George s University of London, London, United Kingdom
    Genet Test 12:457-9. 2008
    ..We investigated a consanguineous family with isolated patent ductus arteriosus (PDA) for mutations in TFAP2B...
  24. ncbi Cardiocirculatory effects of patent ductus arteriosus in extremely low-birth-weight infants with respiratory distress syndrome
    Senji Shimada
    Department of Pediatrics, Iwate Medical University, Morioka, Iwate, Japan
    Pediatr Int 45:255-62. 2003
    Cardiocirculatory effects of hemodynamically significant patent ductus arteriosus (hsPDA) have not been systematically studied in extremely low-birth-weight (ELBW) infants with respiratory distress syndrome (RDS)...
  25. ncbi Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice
    E Segi
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Biochem Biophys Res Commun 246:7-12. 1998
    ..These results suggest that neonatal death is at least partly due to patent ductus arteriosus and that the EP4 receptor plays a role in regulation of the patency of this vessel...
  26. pmc Patent ductus arteriosus therapy: impact on neonatal and 18-month outcome
    Juliette C Madan
    aDivision of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, MA 02111, USA
    Pediatrics 123:674-81. 2009
    The purpose of this work was to evaluate therapy for patent ductus arteriosus as a risk factor for death or neurodevelopmental impairment at 18 to 22 months, bronchopulmonary dysplasia, or necrotizing enterocolitis in extremely low birth ..
  27. ncbi Factors affecting successful closure of hemodynamically significant patent ductus arteriosus with indomethacin in extremely low birth weight infants
    Chuan Zhong Yang
    Department of Neonatology, South Medical University Affiliated Maternal and Child Healthcare Hospital of Shenzhen, Shenzhen 518028, China
    World J Pediatr 4:91-6. 2008
    The incidence of patent ductus arteriosus (PDA) is high in extremely low birth weight (ELBW) infants. Indomethacin has been widely used in the prophylaxis and treatment of hemodynamically significant PDA...
  28. ncbi B-type natriuretic peptide predicts responses to indomethacin in premature neonates with patent ductus arteriosus
    Jong Hau Hsu
    Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Pediatr 157:79-84. 2010
    To determine whether B-type natriuretic peptide (BNP) predicts indomethacin responsiveness in premature neonates with patent ductus arteriosus (PDA).
  29. ncbi Changes in the pathogenesis and prevention of chronic lung disease of prematurity
    E Bancalari
    Department of Pediatrics, University of Miami School of Medicine, FL 33101, USA
    Am J Perinatol 18:1-9. 2001
    ..data strongly suggest that infections, either prenatal or nosocomial, and the presence of a patent ductus arteriosus (PDA) play a major role in the development of CLD in these infants...
  30. ncbi Indomethacin responsiveness of patent ductus arteriosus and renal abnormalities in preterm infants treated with indomethacin
    Kazuo Itabashi
    Children s Medical Center, Northern Yokohama Hospital, 35 1 Chigasakityuo, Tsuzukiku, Yokohama 224 8503, Japan
    J Pediatr 143:203-7. 2003
    We evaluated the factors related to indomethacin responsiveness of the patent ductus arteriosus (PDA) and subsequent renal and electrolyte abnormalities in a large number of low birth weight infants.
  31. ncbi Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants
    M M Tatli
    Division of Neonatology, Department of Paediatrics, Dokuz Eylul University, Izmir, Turkey
    Acta Paediatr 93:999-1001. 2004
    To discuss intestinal side effects of ibuprofen in the treatment of patent ductus arteriosus, after having observed two cases of spontaneous intestinal perforation following ibuprofen treatment.
  32. pmc Severity of the ductal shunt: a comparison of different markers
    M El Hajjar
    Clinique de Médecine Néonatale, Hopital Jeanne de Flandre, CHRU de Lille, Lille, France
    Arch Dis Child Fetal Neonatal Ed 90:F419-22. 2005
    ..When the ductus arteriosus (DA) is patent, the ductal shunt is proportional to the ratio of left ventricular output (LVO) to systemic blood flow. Systemic blood flow can be estimated by measuring flow in the superior vena cava (SVC)...
  33. ncbi Mesenteric oxyhemoglobin desaturation improves with patent ductus arteriosus ligation
    S D Meier
    Division of Pediatric Cardiology, Baylor College of Medicine, Texas Children s Hospital, Houston, 77030, USA
    J Perinatol 26:562-4. 2006
    ..monitor cerebral and mesenteric regional oximetry in a preterm neonate undergoing surgical ligation of a patent ductus arteriosus. This patient initially demonstrated severe mesenteric oxyhemoglobin desaturation, which improved ..
  34. ncbi Comparison of suture ligation and clip application for the treatment of patent ductus arteriosus in preterm neonates
    Parkash Lal Mandhan
    Department of Paediatric Surgery, Waikato Hospital, Hamilton, New Zealand
    J Thorac Cardiovasc Surg 132:672-4. 2006
    We reviewed the experience of 2 centers performing surgical ligation of patent ductus arteriosus in preterm neonates to identify whether the choice of surgical technique--suture ligation or clip application--affected outcome.
  35. ncbi Ibuprofen in the management of neonatal Patent Ductus Arteriosus
    Simon Keady
    Women and Children s Services, University College London Hospitals NHS Foundation Trust, UK
    Intensive Crit Care Nurs 21:56-8. 2005
    b>Patent Ductus Arteriosus (PDA) has a prevalence of approximately 25% in neonates of less than 33 weeks gestation. Failure to treat increases the mortality risk in these preterm infants...
  36. pmc Does patent ductus arteriosus affect feed tolerance in preterm neonates?
    S K Patole
    Department of Neonatal Paediatrics, King Edward Memorial Hospital for Women, Bagot Road, Perth, Western Australia 6008, Australia
    Arch Dis Child Fetal Neonatal Ed 92:F53-5. 2007
    b>Patent ductus arteriosus (PDA), especially PDA with sepsis, has been reported as a risk factor for feed intolerance in preterm neonates...
  37. ncbi Moyamoya angiopathy with dolichoectatic internal carotid arteries, patent ductus arteriosus and pupillary dysfunction: a new genetic syndrome?
    Nadia Khan
    Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, CH 8091 Zurich, Switzerland
    Eur Neurol 51:72-7. 2004
    ..carotid arteries in combination with iris hypoplasia with bilateral fixed dilated pupils and a history of patent ductus arteriosus. Both were symptomatic with moyamoya angiopathy and underwent bilateral extracranial-intracranial (EC-IC) ..
  38. ncbi Oral ibuprofen prophylaxis for symptomatic patent ductus arteriosus of prematurity
    V Sangtawesin
    Neonatal Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, Ministry of Public Health, Bangkok, Thailand
    J Med Assoc Thai 89:314-21. 2006
    ..The oral suspension form of ibuprofen has been shown to have the same efficacy and safety as indomethacin in the treatment of symptomatic PDA, however its role is still questionable in the prophylaxis of symptomatic PDA...
  39. ncbi Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus
    Roberta L Keller
    Department of Pediatrics, University of California, San Francisco 94143, USA
    Pediatrics 112:583-7. 2003
    ..produces ductus arteriosus constriction in extremely premature newborns, a recurrent symptomatic patent ductus arteriosus (PDA) frequently develops after the initial course of indomethacin...
  40. ncbi Effectiveness and side effects of an escalating, stepwise approach to indomethacin treatment for symptomatic patent ductus arteriosus in premature infants below 33 weeks of gestation
    Markus Sperandio
    Division of Neonatology, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    Pediatrics 116:1361-6. 2005
    Symptomatic patent ductus arteriosus (sPDA) is a common problem in premature infants and can be treated effectively with intravenous indomethacin, leading to permanent ductal closure in 70% to 80% of infants...
  41. ncbi N-terminal-pro-B-type natriuretic peptide in premature patent ductus arteriosus: a physiologic biomarker, but is it a clinical tool?
    Cathy Hammerman
    Department of Neonatology, Shaare Zedek Medical Center, POB 3235, 91031 Jerusalem, Israel
    Pediatr Cardiol 31:62-5. 2010
    ..peptide (NT-proBNP) levels could serve as prognostic indicators of the therapeutic responsiveness of the patent ductus arteriosus to pharmacologic treatment...
  42. ncbi Congenital Heart Surgery Nomenclature and Database Project: patent ductus arteriosus, coarctation of the aorta, interrupted aortic arch
    C L Backer
    Department of Surgery, Northwestern University Medical School, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Ann Thorac Surg 69:S298-307. 2000
    The extant nomenclature for patent ductus arteriosus (PDA), coarctation of the aorta (CoAo), and interrupted aortic arch (IAA) is reviewed for the purpose of establishing a unified reporting system...
  43. ncbi Scoliosis in patients with aortic coarctation and patent ductus arteriosus: does standard posterolateral thoracotomy play a role in the development of the lateral curve of the spine?
    Marek Roclawski
    Department of Orthopaedics, Medical University of Gdansk, Nowe Ogrody 1 6, 80 803 Gdansk, Poland
    Pediatr Cardiol 30:941-5. 2009
    ..on the development of scoliosis in subjects undergoing repair of coarctation of the aorta (CoA) and patent ductus arteriosus (PDA). A group of 133 patients with CoA and PDA was evaluated...
  44. ncbi Should all newborns who undergo patent ductus arteriosus ligation be examined for vocal fold mobility?
    Marshall E Smith
    University of Utah School of Medicine, Salt Lake City, USA
    Laryngoscope 119:1606-9. 2009
    To determine the incidence of left vocal fold paralysis (LVFP) in premature infants who undergo patent ductus arteriosus (PDA) ligation.
  45. ncbi Beat-to-beat blood pressure variability and patent ductus arteriosus in ventilated, premature infants
    Alain Beuchée
    Department of Paediatrics, Neonatal Intensive Care Unit, Pavillon Le Chartier, CHU Pontchaillou, 35033, Rennes Cedex 09, France
    Pflugers Arch 446:154-60. 2003
    ..It is concluded that respiratory related BPV involves both diastolic and systolic blood pressure and is correlated to the magnitude of left-to-right transductal shunting in the population studied...
  46. ncbi Surfactant and patent ductus arteriosus
    Abhay Kumar
    Monash Newborn Monash, Medical Centre, Clayton, Vic, Australia
    Indian J Pediatr 77:51-5. 2010
    ..To investigate the relationship between surfactant replacement therapy and the development of a haemodynamically significant ductus arteriosus...
  47. ncbi Prophylaxis of symptomatic patent ductus arteriosus with oral ibuprofen in very low birth weight infants
    Chaisit Sangtawesin
    Cardiology Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, Department of Medical Services, Thailand
    J Med Assoc Thai 91:S28-34. 2008
    b>Patent ductus arteriosus (PDA) is a common cause of mortality and morbidity among very low birth weight infants...
  48. ncbi Can early echocardiographic findings predict patent ductus arteriosus?
    Przemko Kwinta
    Department of Pediatrics, Jagiellonian University, Cracow, Poland
    Neonatology 95:141-8. 2009
    ..Early treatment of a high-risk population is alternative to the routine prophylactic use of PSI, but it remains unclear which newborn is at greatest risk for patent ductus arteriosus (PDA).
  49. ncbi Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus
    Ling Yi Chang
    Department of Medicine, University of Colorado, Denver, Colorado 80204, USA
    Pediatr Res 63:299-302. 2008
    Premature newborn baboons [125 d (67%) gestation], exposed to a moderate-size patent ductus arteriosus (PDA) [pulmonary-to-systemic blood-flow-ratio (Qp/Qs) = 1...
  50. ncbi Hypotension in preterm infants with significant patent ductus arteriosus: effects of dopamine
    Antoine Bouissou
    Department of Perinatal Medicine, Hopital Jeanne de Flandre, CHRU Lille, France
    J Pediatr 153:790-4. 2008
    To study the effects of dopamine on systemic arterial pressure (SAP) and systemic blood flow (SBF) (estimated with the superior vena cava [SVC] flow) in preterm infants with hypotension and patent ductus arteriosus (PDA).
  51. ncbi Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial
    Priya Jegatheesan
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, California 94143 0544, USA
    J Pediatr 153:183-9. 2008
    We conducted a multicenter, randomized, controlled trial to determine whether higher doses of indomethacin would improve the rate of patent ductus arteriosus (PDA) closure.
  52. ncbi Patent ductus arteriosus in preterm neonates
    Ramesh Agarwal
    Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Indian J Pediatr 75:277-80. 2008
    ..on day 3-4 in a ventilated neonate and unexplained metabolic acidosis may be the earliest indicators of a patent ductus arteriosus (PDA). Indomethacin is the main stay of medical management of PDA in preterm neonates...
  53. doi Evidence for active closure of patent ductus arteriosus in very preterm infants
    David B Knight
    J Pediatr 152:446-7; author reply 447-8. 2008
  54. ncbi The effect of ductal diameter on surgical and medical closure of patent ductus arteriosus in preterm neonates: size matters
    Scott Tschuppert
    Division of Congenital Cardiovascular Surgery, University Children s Hospital, University of Zurich, Zurich, Switzerland
    J Thorac Cardiovasc Surg 135:78-82. 2008
    We sought to analyze the effect of patent ductus arteriosus diameter on treatment success in premature neonates.
  55. ncbi Orogastric and intravenous indomethacin administration to very premature neonates with patent ductus arteriosus: population pharmacokinetics, absolute bioavailability, and treatment outcome
    Mohammed Al Za'abi
    School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia
    Ther Drug Monit 29:807-14. 2007
    ..was developed after administration of orogastric and/or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants...
  56. ncbi Neurodevelopmental outcome after COX inhibitor treatment for patent ductus arteriosus
    C Rheinlaender
    Department of Neonatology, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Early Hum Dev 86:87-92. 2010
    ..results in very low birth weight (VLBW) infants two years after successful or failed cyclooxygenase inhibitor treatment with either indomethacin or ibuprofen for a haemodynamically significant patent ductus arteriosus (hsPDA).
  57. ncbi Prophylactic indomethacin reduces grades III and IV intraventricular hemorrhages when compared to early indomethacin treatment of a patent ductus arteriosus
    Toby Debra Yanowitz
    University of Pittsburgh School of Medicine and the Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    J Perinatol 23:317-22. 2003
    ..To determine the relative risk of severe intraventricular hemorrhage (IVH) between two very early indomethacin treatment strategies...
  58. ncbi Near-infrared spectroscopy as a screening tool for patent ductus arteriosus in extremely low birth weight infants
    Mark A Underwood
    Division of Neonatology, Department of Pediatrics, Davis School of Medicine, University of California, Davis, CA 95616, USA
    Neonatology 91:134-9. 2007
    b>Patent ductus arteriosus (PDA) is frequent and potentially pathologic in preterm infants. A simple bedside tool to screen for ductal patency would assist in the care of extremely low birth weight (ELBW) infants.
  59. ncbi Noninvasive diagnosis of aortic coarctation in neonates with patent ductus arteriosus
    Chun Wei Lu
    Department of Pediatrics, Shin Kong Wu Ho Su Memorial Hospital, National Taiwan University, No 7 Chung Shan South Road, 100 Taipei, Taiwan
    J Pediatr 148:217-21. 2006
    To find a noninvasive method to detect coarctation of the aorta (CoA) in the presence of a patent ductus arteriosus (PDA) in neonates.
  60. pmc Conservative treatment for patent ductus arteriosus in the preterm
    Sophie Vanhaesebrouck
    Neonatal Intensive Care, Ziekenhuis Oost Limburg, Genk, Belgium
    Arch Dis Child Fetal Neonatal Ed 92:F244-7. 2007
    A patent ductus arteriosus (PDA) is common among preterms, and prophylactic medical treatment has been advocated as the first-line approach...
  61. ncbi Pulmonary endarteritis and subsequent embolization to the lung as a complication of a patent ductus arteriosus--a case report
    Mehmet Bilge
    Department of Cardiology, Medical Faculty, Zonguldak Karaelmas University, Zonguldak, Turkey
    Angiology 55:99-102. 2004
    ..describe a case of pulmonary endarteritis and subsequent embolization to the lungs as a complication of a patent ductus arteriosus (PDA)...
  62. ncbi Indications for open lung biopsy in patients with ventricular septal defect and/or patent ductus arteriosus with pulmonary hypertension
    S Yamaki
    Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan
    Heart Vessels 5:166-71. 1990
    ..m2 in patients with ventricular septal defect (VSD) and/or patent ductus arteriosus (PDA) with severe pulmonary hypertension...
  63. ncbi Comparison of intravenous and enteral indomethacin administration for closure of patent ductus arteriosus in extremely-low-birth-weight infants
    Pei Chen Tsao
    Institute of Emergency and Critical Care Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan, R O C
    J Chin Med Assoc 73:15-20. 2010
    The objective of this retrospective cohort study was to compare the patent ductus arteriosus (PDA) closure rate with different routes (intravenous and enteral) of indomethacin treatment and neonatal outcomes.
  64. ncbi Incidental discovery of a patent ductus arteriosus in adults
    Harvey D Cassidy
    Department of Family Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA
    J Am Board Fam Med 22:214-8. 2009
    b>Patent ductus arteriosus (PDA) is an uncommon clinical finding in adult primary care patients...
  65. ncbi Plasma brain natriuretic peptide as a predictor of haemodynamically significant patent ductus arteriosus in preterm infants
    V F Puddy
    Regional Neonatal Unit, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Clin Sci (Lond) 103:75-7. 2002
    b>Patent ductus arteriosus (PDA) is an important cause of morbidity in extremely preterm infants...
  66. ncbi Left vocal cord paralysis associated with long-standing patent ductus arteriosus
    M Nakahira
    Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, 783-8505, Japan
    AJNR Am J Neuroradiol 22:759-61. 2001
    SUMMARY: Left vocal cord paralysis in association with patent ductus arteriosus is unusual...
  67. ncbi Congenital sternal cleft with patent ductus arteriosus: report of a case
    Norihiko Ishikawa
    Department of Thoracic Surgery, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
    Surg Today 32:66-8. 2002
    ..The patient was a full-term baby girl with a superior incomplete sternal cleft with patent ductus arteriosus (PDA)...
  68. ncbi Interruption of patent ductus arteriosus in children: robotically assisted versus videothoracoscopic surgery
    Emmanuel Le Bret
    Institut Mutualiste Montsouris, Paris, France
    J Thorac Cardiovasc Surg 123:973-6. 2002
    ..This study analyzes the feasibility, safety, and efficiency of a robotically assisted technique for patent ductus arteriosus closure and compares the results with those of the videothoracoscopic technique.
  69. ncbi Transcatheter closure of the patent ductus arteriosus using an Amplatzer duct occluder in adults
    C H Lee
    Cardiac Medical Unit, Grantham Hospital, Hong Kong
    Jpn Heart J 42:533-7. 2001
    b>Patent ductus arteriosus (PDA) is a congenital heart disease that frequently escapes detection until the patient reaches adulthood...
  70. ncbi Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study
    Shaul Dollberg
    Department of Neonatology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel
    J Pediatr Gastroenterol Nutr 40:184-8. 2005
    b>Patent ductus arteriosus is a risk factor for the development of necrotizing enterocolitis...
  71. pmc An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 65:629-36. 2008
    Ibuprofen is a nonsteroidal anti-inflammatory agent that induces closure of the patent ductus arteriosus in neonates...
  72. ncbi Three-dimensional rotational digital angiography in a complicated case of patent ductus arteriosus transcatheter closure
    Gianluca Rigatelli
    Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Rovigo, Italy
    Catheter Cardiovasc Interv 70:900-3. 2007
    ..We present a case of a difficult patent ductus arteriosus in which 3D rotational angiography was the key to successful closure...
  73. ncbi Influence of a patent ductus arteriosus on cardiac troponin T levels in preterm infants
    Afif F El-Khuffash
    Department of Neonatology, National Maternity Hospital, Dublin, Ireland
    J Pediatr 153:350-3. 2008
    To evaluate the effect of patent ductus arteriosus (PDA) on the myocardium by measuring levels of cardiac troponin T (cTnT), a marker of ischemic myocardial damage.
  74. ncbi Transcatheter closure of patent ductus arteriosus in adults using the Amplatzer duct occluder: initial results and follow-up
    Thomas E Hong
    Section of Pediatric Cardiology, The University of Chicago Children s Hospital, IL 60637, USA
    Indian Heart J 54:384-9. 2002
    Surgical closure of patent ductus arteriosus in adult patients may be problematic. Transcatheter closure of patent ductus arteriosus is an established procedure...
  75. ncbi Feasibility and safety of transcatheter intervention for complex patent ductus arteriosus
    Shi wei Yang
    12th Ward, Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Chao Yang District, Beijing, China
    Angiology 61:372-6. 2010
    We evaluated the transcatheter intervention of complex patent ductus arteriosus (PDA) in Chinese adults. Between January 2004 and April 2008, 112 adult patients (43 males, 69 females, mean age 31 +/- 19 years) underwent intervention...
  76. ncbi [Effects of transcatheter closure of patent ductus arteriosus in 139 adult patients]
    Xian yang Zhu
    Department of Congenital Heart Disease, General Hospital of Shenyang Military Region, Shenyang 110016, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:998-1000. 2009
    To analyze the clinical feature and the effects of transcatheter closure of adult patients with patent ductus arteriosus (PDA).
  77. ncbi Late embolization of Amplatzer patent ductus arteriosus occlusion device with thoracic aorta embedment
    David Michael McMullan
    Cardiovascular Surgery, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Ann Thorac Surg 83:1177-9. 2007
    An 11.5-month-old child was found to have a widely patent ductus arteriosus 8 months after percutaneous Amplatzer device closure of the ductus. Angiography confirmed that the occlusion device had migrated to the descending thoracic aorta...
  78. ncbi Current controversies in the diagnosis and treatment of patent ductus arteriosus in preterm infants
    Nick Evans
    Department of Neonatal Medicine, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
    Adv Neonatal Care 3:168-77. 2003
    ..regarding the preferential use of echocardiography rather than reliance on clinical signs to diagnose patent ductus arteriosus. The rationale for the treatment of symptomatic versus presymptomatic versus prophylactic is compared and ..
  79. ncbi Echocardiography predicts closure of patent ductus arteriosus in response to ibuprofen in infants less than 28 week gestational age
    Christiane Pees
    Department of Neonatology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Early Hum Dev 86:503-8. 2010
    b>Patent ductus arteriosus (PDA) is a frequent problem in preterm infants, and its incidence is inversely correlated with gestational age...
  80. ncbi Totally endoscopic robotic-assisted repair of patent ductus arteriosus and vascular ring in children
    Yoshihiro Suematsu
    Department of Cardiac Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Thorac Surg 80:2309-13. 2005
    This study reports on our initial experience with robotically assisted patent ductus arteriosus (PDA) closure and vascular ring division in children.
  81. ncbi Transcatheter closure of patent ductus arteriosus
    S Shrivastava
    Escorts Heart Institute and Research Center, Okhla Road, New Delhi 110 025, India
    Indian Pediatr 37:1307-13. 2000
    ..To present short and intermediate results of catheter closure of patent ductus artereiosus using spring coils and Amplatzer duct occluder...
  82. ncbi Analysis of outcome in 298 extremely low-birth-weight infants with patent ductus arteriosus
    Frederick Alexander
    Hackensack University Medical Center, Hackensack, NJ 07601, USA
    J Pediatr Surg 44:112-7; disscusion 117. 2009
    Indomethacin is accepted therapy for patent ductus arteriosus (PDA) in ELBW infants (<1000 g). We hypothesize that surgical ligation may provide comparatively superior outcomes in select ELBW infants.
  83. ncbi The pharmacologic closure of the patent ductus arteriosus
    Bart Van Overmeire
    Department of Pediatrics, Neonatal Intensive Care Unit, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Semin Fetal Neonatal Med 10:177-84. 2005
    ..This chapter focuses on some of the basic mechanisms underlying ductal patency and the clinical attempts to diminish side effects associated with indomethacin, including the alternative use of ibuprofen...
  84. ncbi Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus
    Alan M Fujii
    Department of Pediatrics, Boston University School of Medicine, Boston Medical Center, Boston, MA 02218, USA
    J Perinatol 22:535-40. 2002
    ..the highest mortality and morbidity rates, to reduce the incidence of intraventricular hemorrhage and patent ductus arteriosus (PDA)...
  85. ncbi Retrospective economic evaluation of a controlled trial of indomethacin prophylaxis for patent ductus arteriosus in premature infants
    John A F Zupancic
    Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Early Hum Dev 82:97-103. 2006
    ..To determine the incremental cost-effectiveness of indomethacin prophylaxis in extremely low birth weight infants enrolled in the Trial of Indomethacin Prophylaxis in Preterms (TIPP)...
  86. ncbi Early or late surgical ligation of medical refractory patent ductus arteriosus in premature infants
    Chien Chou Hsiao
    Department of Pediatrics, Children s Hospital, Changhua Christian Hospital, Changhua, College of Health Sciences, Chang Jung Christian University, Tainan, Taiwan
    J Formos Med Assoc 108:72-7. 2009
    Optimal time to surgical ligation of patent ductus arteriosus (PDA) in very-low-birth-weight (< 1500 g) premature infants remains an area of controversy...
  87. ncbi The physiopathology of the patent ductus arteriosus
    Paolo Giliberti
    Neonatal Intensive Care Unit, Monaldi Hospital, Naples, Italy
    J Matern Fetal Neonatal Med 22:6-9. 2009
    b>Patent ductus arteriosus (PDA) remains a frequent problem for the very low birth weight infants...
  88. ncbi Effects of coil closure of patent ductus arteriosus on left anterior descending coronary artery blood flow using transthoracic Doppler echocardiography
    Kenji Harada
    Department of Pediatrics, Ajkita University School of Medicine, Japan
    J Am Soc Echocardiogr 17:659-63. 2004
    ..Coil closure of patent ductus arteriosus (PDA) is a model of acute changes in blood pressure and left ventricular (LV) preload that influences ..
  89. ncbi Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus
    Donough J O'Donovan
    Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Houston, TX 77030, USA
    J Perinatol 23:286-90. 2003
    Indomethacin is the most frequently used pharmacological agent for closure of a patent ductus arteriosus (PDA) in premature infants...
  90. ncbi Effect of patent ductus arteriosus and indomethacin treatment on serum cardiac troponin T levels in preterm infants with respiratory distress syndrome
    D Trevisanuto
    Department of Pediatrics, University of Padova, Italy
    Eur J Pediatr 159:273-6. 2000
    ..The aim of this study was to detect the potential ischemic effect of persistent patent ductus arteriosus (PDA) and indomethacin treatment on the coronary vascular bed by measuring cTnT concentrations...
  91. pmc Closure of a large patent ductus arteriosus in adults: first do no harm
    Michael L Rigby
    Heart 93:417-8. 2007
  92. ncbi Links between early adrenal function and respiratory outcome in preterm infants: airway inflammation and patent ductus arteriosus
    K L Watterberg
    Department of Pediatrics, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Pediatrics 105:320-4. 2000
    To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.
  93. ncbi Acute renal impairment after oral ibuprofen for medical closure of patent ductus arteriosus
    Filiz Tiker
    Indian Pediatr 44:54-5. 2007
  94. ncbi Indomethacin prophylaxis or expectant treatment of patent ductus arteriosus in extremely low birth weight infants?
    L Cordero
    1Division of Neonatal Perinatal Medicine, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA
    J Perinatol 27:158-63. 2007
    Indomethacin prophylaxis or expectant treatment are common strategies for the prevention or management of symptomatic patent ductus arteriosus (sPDA).
  95. ncbi Morphologic assessment of patent ductus arteriosus in adults using retrospectively ECG-gated multidetector CT
    Gareth J Morgan-Hughes
    Department of Cardiology, South West Cardiothoracic Centre, Plymouth National Health Service Trust, Derriford, Plymouth PL6 8DH, United Kingdom
    AJR Am J Roentgenol 181:749-54. 2003
    Noninvasive imaging of a persistently patent ductus arteriosus in adults remains a challenge...
  96. ncbi Patent ductus arteriosus ligation is associated with impaired left ventricular systolic performance in premature infants weighing less than 1000 g
    Patrick J McNamara
    Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 140:150-7. 2010
    b>Patent ductus arteriosus ligation is often complicated by systemic hypotension and oxygenation failure. The ability of the immature myocardium to compensate for altered afterload is poorly understood...
  97. ncbi Patent ductus arteriosus
    Douglas J Schneider
    University of Illinois College of Medicine at Peoria, and Cardiac Catheterization Laboratory, Children s Hospital of Illinois, 420 NE Glen Oak Ave, Suite 304, Peoria, IL 61603, USA
    Circulation 114:1873-82. 2006
  98. ncbi Predictors of failed closure of patent ductus arteriosus with indomethacin
    N Y Boo
    Department of Paediatrics, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia
    Singapore Med J 47:763-8. 2006
    The aim of this study was to determine predictors of failed closure of patent ductus arteriosus (PDA) following a single course of indomethacin in symptomatic preterm infants.
  99. ncbi Indomethacin prophylaxis, patent ductus arteriosus, and the risk of bronchopulmonary dysplasia: further analyses from the Trial of Indomethacin Prophylaxis in Preterms (TIPP)
    Barbara Schmidt
    Department of Pediatrics and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Pediatr 148:730-734. 2006
    To determine the risk of bronchopulmonary dysplasia (BPD) in subgroups of infants with and without patent ductus arteriosus (PDA) who were randomized to indomethacin prophylaxis or placebo, and to examine whether adverse drug effects on ..
  100. ncbi Early hemodynamic consequences of patent ductus arteriosus in preterm infants with intrauterine growth restriction
    T Rakza
    Clinique de Médecine Néonatale, Hopital Jeanne de Flandre, CHRU de Lille, France
    J Pediatr 151:624-8. 2007
    To test the hypothesis that significant patent ductus arteriosus (PDA) may occur very early after birth in preterm infants with intrauterine growth restriction (IUGR), we compared the longitudinal changes in left-to-right shunting through ..
  101. ncbi Utility of transesophageal echocardiography in the examination of adult patients with patent ductus arteriosus
    A Andrade
    Department of Echocardiography, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, D F, Mexico
    Am Heart J 130:543-6. 1995
    Thirteen patients with clinical suspicion of patent ductus arteriosus were evaluated by transthoracic and transesophageal echocardiographic studies...

Research Grants33

  1. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2006
    ..If left unclosed, a persistent patent ductus arteriosus (PDA) is associated with significant morbidity: increased severity of bronchopulmonary dysplasia, a ..
  2. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..feeding and the use of indomethacin, the standard of care to treat and/or prevent the development of Patent Ductus Arteriosus (PDA)...
  3. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2013
    ..feeding and the use of indomethacin, the standard of care to treat and/or prevent the development of Patent Ductus Arteriosus (PDA), a condition which results in the circulation short-circuiting the pulmonary vasculature, leading ..
  4. Role of natriuretic peptides in the ductus arteriosus
    JOHN JEFFREY REESE; Fiscal Year: 2013
    ..Infants with patent ductus arteriosus (PDA) have increased ANP and BNP levels due to cardiac overload...
  5. Myocardin Related Transcription Factor Function in the Vasculature
    Michael S Parmacek; Fiscal Year: 2013
    ..genes, iii) mice in which the myocardin gene is ablated in neural crest-derived SMCs exhibit patent ductus arteriosus (PDA) resulting from a block in SMC differentiation, iv) myocardin-deficient primary aortic SMCs assume a ..
  6. Genes contributing to patent ductus arteriosus susceptibility in preterm newborns
    Ronald I Clyman; Fiscal Year: 2013
    ..Each year, approximately 25,000 premature newborns are treated for a symptomatic, persistent patent ductus arteriosus (PDA) in the United States...
  7. Neurodevelopmental Outcomes in Infants with HLHS after Hybrid Stage I Palliation
    Sharon L Hill; Fiscal Year: 2011
    ..After the Hybrid procedure, cerebral perfusion is dependent upon the blood flow through the stented patent ductus arteriosus and retrograde aortic arch flow to the carotid arteries, similar to fetal life, for approximately 6 ..
  8. Mechanism of Renal Prostaglandin Transport
    Victor L Schuster; Fiscal Year: 2010
    ..Mice in which we have globally disrupted PGT gene expression die on post-natal day 1 from patent ductus arteriosus. In contrast, mice in which we have selectively deleted PGT from the collecting duct excrete dilute urine,..
  9. Removable Stents for Neonates with Cyanotic Congenital Heart Disease(CCHD)
    JAMES HUNTER GOLDIE; Fiscal Year: 2013
    ..A promising alternative treatment calls for placing a stent in te patent ductus arteriosus (PDA), in order to delay definitive repair until the child is older and wil have a lower risk...
  10. ETIOLOGY AND DEVELOPMENT OF CONGENITAL HEART DISEASES
    Donald Patterson; Fiscal Year: 1999
    ..mechanisms underlying two hereditary forms of congenital heart disease: Conotruncal defects (CTDs) and patent ductus arteriosus (PDA)...
  11. REPRODUCTION AND SURVIVAL AFTER CARDIAC DEFECT REPAIR
    Cynthia Morris; Fiscal Year: 1991
    ..TOF), coarctation of the aorta, aortic stenosis (AS), transposition of the great arteries (TGA), and patent ductus arteriosus (PDA)...
  12. The Genetic Etiology of Patent Ductus Arteriosus
    Arya Mani; Fiscal Year: 2006
    ..Failure of postnatal closure of this muscular artery, patent ductus arteriosus (PDA), is one of the most common genital cardiovascular defects...
  13. ETIOLOGY AND DEVELOPMENT OF CONGENITAL HEART DISEASE
    Paula Henthorn; Fiscal Year: 2006
    ..The common anatomic forms of CHD include conotruncal defects (CTD) and patent ductus arteriosus (PDA)...
  14. SCOR: RESPIRATORY DISORDERS OF NEONATES AND CHILDREN
    WILLIAM TOOLEY; Fiscal Year: 1991
    ..function in infants and to use these methods to determine the importance of the chest wall in maintaining lung stability, to measure blood gases on the skin and to estimate the amount of flow through a patent ductus arteriosus.
  15. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald I Clyman; Fiscal Year: 2010
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
  16. Opposing Effects of pO2 on SOCs in Smooth Muscle Cells
    Edward Weir; Fiscal Year: 2008
    ..A better understanding of the mechanisms of O2-mediated changes in tone in the ductus arteriosus and pulmonary artery would therefore be of significant medical importance. ..
  17. Schizophrenia Predisposition in 22q11 Deletion Syndrome
    Vandana Shashi; Fiscal Year: 2005
    ..abstract_text> ..
  18. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2004
    ..Verbatim from Applicant's Abstract): Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...
  19. Pediatric Cardiac Procedures: Access, Rates and Outcomes
    Darryl Gray; Fiscal Year: 2004
    ..We will address such concerns in the increasingly important but as yet understudied realm of pediatric cardiac interventions. ..
  20. Calorie Restriction Effects on Chromosomal Aberrations
    CHARLEEN MOORE; Fiscal Year: 2003
    ..The results will be essential in identifying potential mechanisms by which CR acts in cancer prevention and delay of the aging process in long-lived species such as the rhesus monkey and humans. ..
  21. SIGNALING OF MECHANICAL STRAIN IN LUNG EPITHELIAL CELLS
    Patricia Chess; Fiscal Year: 2003
    ..The project is designed to optimize the principle investigator's research development, while yielding information regarding pulmonary epithelial responses to mechanical strain. ..
  22. PHONATION AND PHONATORY CONTROL IN VOCAL TREMORS
    Marshall Smith; Fiscal Year: 2002
    ..The experimental phase consists of studies of neuromuscular and respiratory input to the larynx. This information about vocal tremor will be applied to model simulations with the use of physiological signals as input model parameters. ..
  23. Electrode Array Reanimation of the Paralyzed Larynx
    Marshall Smith; Fiscal Year: 2006
    ..Nerve samples will be harvested and studied to examine the effects of the implanted array on RLN fibers. [unreadable] [unreadable]..
  24. Mechanisms of Ductus Arteriosus Regulation
    JOHN JEFFREY REESE; Fiscal Year: 2010
    ..These studies will examine new roles for prostaglandins and their relationship with other vasoactive mediators during development. ..
  25. Safe Pregnancy by Infectious Disease Control in Kinshasa
    Carl Bose; Fiscal Year: 2008
    ..It will also build upon, and augment, a burgeoning, multidisciplinary research and training program at the Kinshasa School of Public Health. ..
  26. Disease pathogenesis of Noonan syndrome and related disorders
    Bruce Gelb; Fiscal Year: 2008
    ..Char syndrome, which has a phenotype that includes patent ductus arteriosus, is caused by transcription factor AP-2beta dominant-negative mutations...
  27. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2008
    ..abstract_text> ..
  28. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
  29. The Role of IgLONS in Cardiac Development and Disease
    Paul Grossfeld; Fiscal Year: 2007
    ..abstract_text> ..
  30. PROSTAGLANDIN SIGNALING IN FEMALE REPRODUCTION
    John Reese; Fiscal Year: 2005
    ..The results of these experiments will enhance the understanding of maternal-fetal PG signaling, and are likely to provide new insights into premature or dysfunctional labor in women. ..
  31. Metabolism-excitation coupling in the heart
    Colin Nichols; Fiscal Year: 2005
    ..The work will provide information that will ultimately underlie the development of rational therapies for the treatment of cardiac ischemia and arrhythmias. ..
  32. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..