cardiovascular pregnancy complications

Summary

Summary: The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.

Top Publications

  1. ncbi Factor analysis, including antihypertensive medication, of the outcome of pregnancy in pregnancy-associated hypertension
    M Hussein
    Department of Nephrology, Dialysis and Hypertension, Al Hada Armed Forces Hospital, Taif, Saudi Arabia
    Kidney Blood Press Res 24:124-8. 2001
  2. ncbi Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Graduate School of Public Health, University of Pittsburgh, and Magee Womens Research Institute, Pittsburgh, PA, USA
    Hypertension 41:437-45. 2003
  3. ncbi Prospective multicenter study of pregnancy outcomes in women with heart disease
    S C Siu
    University of Toronto, Toronto, Ontario, Canada
    Circulation 104:515-21. 2001
  4. ncbi Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves
    N Vitale
    Department of Cardiac Surgery, Medical School, Monaldi Hospital, Second University of Naples, Italy
    J Am Coll Cardiol 33:1637-41. 1999
  5. ncbi Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study
    John A Heit
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 143:697-706. 2005
  6. ncbi Risk of warfarin during pregnancy with mechanical valve prostheses
    Maurizio Cotrufo
    Department of Cardio Thoracic and Respiratory Sciences, V Monaldi Hospital, Naples, Italy
    Obstet Gynecol 99:35-40. 2002
  7. ncbi Peripartum cardiomyopathy: National Heart, Lung, and Blood Institute and Office of Rare Diseases (National Institutes of Health) workshop recommendations and review
    G D Pearson
    Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 7940, USA
    JAMA 283:1183-8. 2000
  8. ncbi Coronary artery dissection during pregnancy and the postpartum period: two case reports and review of literature
    A K Koul
    Division of Cardiology, Maimonides Medical Center, Brooklyn, New York 11219, USA
    Catheter Cardiovasc Interv 52:88-94. 2001
  9. ncbi Improved outcomes in peripartum cardiomyopathy with contemporary
    Ankie M Amos
    Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    Am Heart J 152:509-13. 2006
  10. ncbi Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database
    E L Simpson
    Postgraduate Medical School, Guildford, Surrey, UK
    BJOG 108:56-60. 2001

Research Grants

Detail Information

Publications203 found, 100 shown here

  1. ncbi Factor analysis, including antihypertensive medication, of the outcome of pregnancy in pregnancy-associated hypertension
    M Hussein
    Department of Nephrology, Dialysis and Hypertension, Al Hada Armed Forces Hospital, Taif, Saudi Arabia
    Kidney Blood Press Res 24:124-8. 2001
    ..This was not seen in the patients using nifedipine and labetalol. CONCLUSIONS: The results suggest that in multiparas, intravenous hydralazine is possibly associated with more fetal distress when compared to primiparas...
  2. ncbi Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Graduate School of Public Health, University of Pittsburgh, and Magee Womens Research Institute, Pittsburgh, PA, USA
    Hypertension 41:437-45. 2003
    ..Recommendations to increase participation in this research are also presented...
  3. ncbi Prospective multicenter study of pregnancy outcomes in women with heart disease
    S C Siu
    University of Toronto, Toronto, Ontario, Canada
    Circulation 104:515-21. 2001
    ..The maternal and neonatal risks associated with pregnancy in women with heart disease receiving comprehensive prenatal care have not been well defined...
  4. ncbi Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves
    N Vitale
    Department of Cardiac Surgery, Medical School, Monaldi Hospital, Second University of Naples, Italy
    J Am Coll Cardiol 33:1637-41. 1999
    ..The purpose of this study was to assess the incidence of warfarin fetal complications and whether they are dose-dependent...
  5. ncbi Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study
    John A Heit
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 143:697-706. 2005
    ..The risk for venous thromboembolism during pregnancy or postpartum is uncertain...
  6. ncbi Risk of warfarin during pregnancy with mechanical valve prostheses
    Maurizio Cotrufo
    Department of Cardio Thoracic and Respiratory Sciences, V Monaldi Hospital, Naples, Italy
    Obstet Gynecol 99:35-40. 2002
    ..To assess the determinants of pregnancy outcome in patients with mechanical valve prostheses anticoagulated with warfarin...
  7. ncbi Peripartum cardiomyopathy: National Heart, Lung, and Blood Institute and Office of Rare Diseases (National Institutes of Health) workshop recommendations and review
    G D Pearson
    Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 7940, USA
    JAMA 283:1183-8. 2000
    ....
  8. ncbi Coronary artery dissection during pregnancy and the postpartum period: two case reports and review of literature
    A K Koul
    Division of Cardiology, Maimonides Medical Center, Brooklyn, New York 11219, USA
    Catheter Cardiovasc Interv 52:88-94. 2001
    ..Diagnostic and therapeutic considerations of this unique clinical entity are discussed and reviewed...
  9. ncbi Improved outcomes in peripartum cardiomyopathy with contemporary
    Ankie M Amos
    Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    Am Heart J 152:509-13. 2006
    ..These studies were small and predated current advances in heart failure treatment. We sought to determine the outcomes of women with PPCM in the contemporary era and to determine predictors of poor outcome...
  10. ncbi Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database
    E L Simpson
    Postgraduate Medical School, Guildford, Surrey, UK
    BJOG 108:56-60. 2001
    ..Antenatally multiple birth is an important risk factor. Postnatally women who have had a caesarean section, premature delivery or history of cardiac disease should be assessed carefully for venous thromboembolism...
  11. ncbi Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
    G J Hofmeyr
    University of the Witwatersrand, University of Fort Hare, Eastern Cape Department of Health, Frere and Cecilia Makiwane Hospitals, Private Bag X 9047, East London, Eastern Cape, South Africa 5200
    Cochrane Database Syst Rev 3:CD001059. 2006
    ..Pre-eclampsia and eclampsia are common causes of serious morbidity and death. Calcium supplementation may reduce the risk of pre-eclampsia through a number of mechanisms, and may help to prevent preterm labour...
  12. ncbi Pregnancy-related mortality due to cardiomyopathy: United States, 1991-1997
    Sara J Whitehead
    Epidemic Intelligence Service, Epidemiology Program Office, National Center for Chronic Diseases Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Obstet Gynecol 102:1326-31. 2003
    ....
  13. ncbi Different anesthesiological management in two high risk pregnant women with heart failure undergoing emergency cesarean section
    A Zangrillo
    Department of Anesthesiology, Vita Salute University of Milan, IRCCS San Raffaele Hospital, 20132 Milan, Italy
    Minerva Anestesiol 71:227-36. 2005
    ..Selection of the anesthetic technique in obstetrics is the most challenging issue for the anesthesiologist: extensive knowledge of the pathophysiology of heart disease is required for an optimal choice...
  14. ncbi Thrombosis during pregnancy and the postpartum period
    Andra H James
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710 and Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 193:216-9. 2005
    ..To describe the circumstances surrounding deep vein thrombosis among pregnant or postpartum patients enrolled in a large multicenter registry...
  15. ncbi Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy
    Ian A Greer
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, United Kingdom
    Blood 106:401-7. 2005
    ..01%-0.20%) of pregnancies. Overall, live births were reported in 94.7% of pregnancies, including 85.4% in those receiving LMWH for recurrent pregnancy loss. LMWH is both safe and effective to prevent or treat VTE in pregnancy...
  16. ncbi Labour analgesia guided by echocardiography in a parturient with primary dilated cardiomyopathy
    Toshiyuki Okutomi
    Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Can J Anaesth 52:622-5. 2005
    ..To evaluate the effects of intrathecal analgesics on cardiac function during labour analgesia using echocardiography in a parturient with idiopathic dilated cardiomyopathy (DCM)...
  17. ncbi Brief review: hypertension in pregnancy : a manifestation of the insulin resistance syndrome?
    C G Solomon
    Division of Women s Health, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hypertension 37:232-9. 2001
    ....
  18. ncbi Combined spinal-epidural anesthesia for Cesarean section in a patient with peripartum dilated cardiomyopathy
    R Shnaider
    Department of Anesthesiology University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Can J Anaesth 48:681-3. 2001
    ..The patient's perioperative course was uneventful. CONCLUSION: In patients suffering from peripartum cardiomyopathy, undergoing Cesarean section, combined spinal-epidural anesthesia may be an acceptable anesthetic alternative...
  19. ncbi Peripartum cardiomyopathy
    Angela Ro
    Department of Medicine, St Vincent s Medical Center, New York, NY 10595, USA
    Cardiol Rev 14:35-42. 2006
    ..This article attempts to provide an updated, comprehensive review about PPCM and draw attention to areas in need of further research...
  20. ncbi A modified definition for peripartum cardiomyopathy and prognosis based on echocardiography
    J U Hibbard
    Department of Obstetrics and Gynecology, University of Chicago, Pritzker School of Medicine, Illinois 60637, USA
    Obstet Gynecol 94:311-6. 1999
    ..The test reproduces hemodynamic stress akin to pregnancy, and the data might be useful when counseling women on future childbearing. Women who respond with reduced cardiac reserve might be advised to avoid pregnancy...
  21. ncbi Pregnancy-associated cardiomyopathy: clinical characteristics and a comparison between early and late presentation
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, and Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Circulation 111:2050-5. 2005
    ..Cardiomyopathy associated with pregnancy was first described more than half a century ago. However, because of its rare occurrence and geographical differences, the clinical profile of this condition has remained incompletely defined...
  22. ncbi Prosthetic heart valves and pregnancy
    Lynne Hung
    Griffith Center, Division of Cardiovascular Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Circulation 107:1240-6. 2003
  23. ncbi Pre-eclampsia and the hypertensive disorders of pregnancy
    Lelia Duley
    Resource Centre for Randomised Trials, Institute of Health Sciences, Headington, Oxford, UK
    Br Med Bull 67:161-76. 2003
    ..Magnesium sulphate more than halves the risk of eclampsia (RR 0.41; 95% CI 0.29, 0.58) and probably reduces the risk of maternal death (RR 0.54; 95% CI 0.26, 1.10). It is also the drug of choice for treatment of eclampsia...
  24. ncbi Prognostic value of placental ultrasound in pregnancies complicated by absent end-diastolic flow velocity in the umbilical arteries
    S Viero
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Placenta 25:735-41. 2004
    ..Ultrasound examination of the placenta and its maternal blood supply may contribute to the perinatal management of these pregnancies...
  25. ncbi Maternal deaths due to hypertensive disorders in pregnancy
    J Moodley
    Department of Obstetrics and Gynaecology, University of KwaZulu Natal, Durban, South Africa
    Best Pract Res Clin Obstet Gynaecol 22:559-67. 2008
    ....
  26. ncbi Maternal and fetal outcomes of subsequent pregnancies in women with peripartum cardiomyopathy
    U Elkayam
    Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA
    N Engl J Med 344:1567-71. 2001
    ..Peripartum cardiomyopathy is a rare and sometimes fatal form of heart failure. Little is known about the outcomes of subsequent pregnancies in women who have had the disorder...
  27. ncbi Pregnancy complicated by heart disease: a review of Canadian experience
    M Sermer
    Department of Obstetrics and Gynaecology, Toronto General Hospital, Toronto, Canada
    J Obstet Gynaecol 23:540-4. 2003
    ..Factors that place the mother and the neonate at risk can be identified before pregnancy. This allows informed counselling and development of a patient-specific management plan...
  28. ncbi Peripartum cardiomyopathy
    H Ardehali
    Division of Cardiology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Minerva Cardioangiol 51:41-8. 2003
    ..Patients who fail to recover may require inotropic therapy, intra-aortic balloon pump and left ventricular assist device as needed. Cardiac transplantation should be considered for patients who fail therapy...
  29. ncbi Pregnancy in patients with heart disease: experience with 1,000 cases
    Walkiria Samuel Avila
    Heart Institute InCor University of São Paulo Medical School Brazil and Department of Obstetrics of the Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Clin Cardiol 26:135-42. 2003
    ..Previously, the high maternal mortality in cardiac patients who became pregnant prompted the assertion: Women with an abnormal heart should not become pregnant. This long-standing notion needs to be revised today...
  30. ncbi Inherited thrombophilia and gestational vascular complications
    Michael J Kupferminc
    Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    Semin Thromb Hemost 29:185-94. 2003
    ..However, controlled clinical trials are still necessary to allow the development of better clinical standards...
  31. ncbi Peripartum cardiomyopathy: inflammatory markers as predictors of outcome in 100 prospectively studied patients
    Karen Sliwa
    Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, PO Bertsham 2013, Johannesburg, South Africa
    Eur Heart J 27:441-6. 2006
    ..We evaluated the prognostic role of multiple inflammatory markers in the plasma of a large cohort of African patients with PPCM...
  32. ncbi Is peripartum cardiomyopathy an organ-specific autoimmune disease?
    J Bruce Sundstrom
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Autoimmun Rev 1:73-7. 2002
    ..g. expression of PD-L1 on cardiac tissues and the role of regulatory T cells, may help to elucidate the autoimmune mechanisms of PPCM...
  33. ncbi Diagnosis and management of gestational hypertension and preeclampsia
    Baha M Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0526, USA
    Obstet Gynecol 102:181-92. 2003
    ..There is also a need to conduct a randomized trial to determine the benefits and risks of magnesium sulfate during labor and postpartum in women with mild preeclampsia...
  34. ncbi Management of grown up congenital heart disease
    John Deanfield
    GUCH Unit, The Heart Hospital, London
    Eur Heart J 24:1035-84. 2003
  35. doi Acute myocardial infarction associated with pregnancy
    Arie Roth
    Department of Cardiology Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
    J Am Coll Cardiol 52:171-80. 2008
    ....
  36. pmc Placental ischemia and cardiovascular dysfunction in preeclampsia and beyond: making the connections
    Jeffrey S Gilbert
    Department of Physiology and Pharmacology, University of Minnesota Medical School Duluth and Duluth Medical Research Institute, Duluth, MN 55812, USA
    Expert Rev Cardiovasc Ther 6:1367-77. 2008
    ..However, the importance of the various endothelial and humoral factors that mediate these changes during PE remain to be elucidated...
  37. ncbi The influence of maternal hypertension on low birth weight: differences among ethnic populations
    J Fang
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ethn Dis 9:369-76. 1999
    ..To determine the influence of maternal hypertension on the risk of low birth weight among white, black, and Hispanic residents of New York City...
  38. ncbi ABO blood groups and risk of venous thromboembolism during pregnancy and the puerperium. A population-based, nested case-control study
    T B Larsen
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense, Denmark
    J Thromb Haemost 3:300-4. 2005
    ..To examine possible associations of ABO blood types with the risk of venous thromboembolism (VTE) in pregnancy and the puerperium...
  39. ncbi Recognition and management of maternal cardiac disease in pregnancy
    P Ray
    Department of Anaesthesia, St Michaels Hospital, Bristol and Department of Cardiac Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Br J Anaesth 93:428-39. 2004
    ..The presence of adequate systems for early detection, appropriate referral to specialist centres, and timely delivery with multidisciplinary support can minimize the serious consequences of poorly controlled heart disease in pregnancy...
  40. ncbi Maternal deaths due to hypertensive disorders in pregnancy: Saving Mothers report 2002-2004
    J Moodley
    Women s Health and HIV Research Group, Nelson R Mandela School of Medicine, Durban
    Cardiovasc J Afr 18:358-61. 2007
    ....
  41. ncbi Five-year prospective study of the incidence and prognosis of peripartum cardiomyopathy at a single institution
    James D Fett
    Department of Adult Medicine, Hopital Albert Schweitzer, Deschapelles, Haiti
    Mayo Clin Proc 80:1602-6. 2005
    ..To determine the incidence and prognosis of peripartum cardiomyopathy (PPCM) in rural Haiti...
  42. ncbi Successful use of levosimendan in a patient with peripartum cardiomyopathy
    Sidney Benlolo
    Department of Anesthesiology and Critical Care Medicine, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Institut Fédératif de Recherche 06, Paris, France
    Anesth Analg 98:822-4, table of contents. 2004
    ..We determined that she met current diagnostic criteria for peripartum cardiomyopathy, and we successfully treated her with levosimendan, a calcium-sensitizing drug with additional vasodilation properties...
  43. ncbi Autoimmune mechanisms as the basis for human peripartum cardiomyopathy
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Room 4107B Winship Cancer Institute, Emory University School of Medicine, 1365 B Clifton Rd, Atlanta, GA 30322, USA
    Clin Rev Allergy Immunol 23:301-24. 2002
    ..A working model for the pathogenesis of this disease is also described herein...
  44. ncbi Peripartum cardiomyopathy
    Karen Sliwa
    Soweto Cardiovascular Research Unit, Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, P O Bertsham 2013, Johannesburg, South Africa
    Lancet 368:687-93. 2006
    ....
  45. ncbi Risks and pregnancy outcome in women with prosthetic mechanical heart valve replacement
    Kazuya Kawamata
    Department of Perinatology, National Cardiovascular Center, Suita, Japan
    Circ J 71:211-3. 2007
    ..In Japan, however, the risks and pregnancy outcomes in women with prosthetic mechanical heart valve replacement remain to be elucidated...
  46. pmc Low molecular weight heparin treatment in pregnant women with a mechanical heart valve prosthesis
    Jae Hoon Lee
    Department of Thoracic and Cardiovascular Surgery, Dongsan Medical Center, Keimyung University School of Medicine, 194 Dongsan dong, Joong Gu, Daegu, Korea
    J Korean Med Sci 22:258-61. 2007
    ..Regarding the efficacy and safety of antithrombotic treatment in pregnant women with prosthetic heart valves, nadroparin treatment during the first trimester is an acceptable regimen and produces better results than coumarin derivatives...
  47. ncbi High prevalence of viral genomes and inflammation in peripartum cardiomyopathy
    Burkhard D Bültmann
    Institute of Pathology, University Hospital of Tubingen, Germany
    Am J Obstet Gynecol 193:363-5. 2005
    ..7%) that were associated immunohistologically with interstitial inflammation. These findings indicate a high prevalence of virus-associated inflammatory changes in peripartum cardiomyopathy...
  48. ncbi Low-molecular-weight heparin for the prevention and treatment of venous thromboembolism in pregnancy
    M D McColl
    Haematology Department, Crosshouse Hospital, Kilmarnock, United Kingdom
    Curr Opin Pulm Med 10:371-5. 2004
    ..However, until recently, evidence in pregnant women was lacking, despite the increasing use of LMWHs during pregnancy in clinical practice. This review covers recent literature on the use of LMWHs in relation to pregnancy...
  49. ncbi Enoxaparin treatment in women with mechanical heart valves during pregnancy
    J A Rowan
    Department of Obstetrics, National Women's Hospital, Auckland, New Zealand
    Am J Obstet Gynecol 185:633-7. 2001
    ..Further data are required before use of enoxaparin during pregnancy in women with mechanical heart valves can be recommended...
  50. ncbi A prospective trial that demonstrates that dalteparin requirements increase in pregnancy to maintain therapeutic levels of anticoagulation
    Linda A Barbour
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Am J Obstet Gynecol 191:1024-9. 2004
    ..The purpose of this study was to determine whether standard therapeutic doses of dalteparin maintain peak therapeutic levels of anticoagulation during pregnancy...
  51. ncbi Anticoagulation of pregnant women with mechanical heart valves
    Jeffrey S Ginsberg
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Arch Intern Med 163:694-8. 2003
    ..We believe a consensus conference among experts in the field to identify key unresolved issues and a commitment by the FDA and industry to perform appropriate studies are now critical...
  52. ncbi Staged therapeutic approach in spontaneous coronary dissection
    Siamak Aliyary
    Department of Cardiology, Medisch Spectrum Twente, Enschede, The Netherlands
    Ann Thorac Surg 83:1879-81. 2007
    ..While she was on aortic balloon counterpulsation the patient underwent a cesarean section and gave birth to a healthy child. Subsequently she successfully underwent off-pump coronary artery bypass surgery...
  53. ncbi Pregnancy and peripartum cardiomyopathy. A comparative and prospective study
    Walkiria Samuel Avila
    Instituto do Coração do Hospital das Clínicas FMUSP, Sao Paulo, Brazil
    Arq Bras Cardiol 79:484-93. 2002
    ..To assess pregnancy outcome in women with peripartum cardiomyopathy and to compare it with idiopathic cardiomyopathy...
  54. ncbi Impact of pregnancy-related heart failure on humoral immunity: clinical relevance of G3-subclass immunoglobulins in peripartum cardiomyopathy
    Rahat S Warraich
    Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College School of Medicine, Royal Brompton and Harefield Trust, Harefield Hospital, Middlesex, England, UK
    Am Heart J 150:263-9. 2005
    ..Therefore, given that progressive gestation is associated with immunologic incompetence, we sought to study the relative impact of pregnancy-related onset of HF on humoral immunity...
  55. ncbi Ruptured renal artery aneurysm in a pregnant woman with solitary kidney
    F Ghanavati
    Ashington General Hospital, Department of Obstetrics and Gynaecology, Ashington, Northumberland, UK
    J Obstet Gynaecol 23:564-6. 2003
  56. ncbi Ruptured renal artery aneurysm during pregnancy: successful ex situ repair and autotransplantation
    H Lacroix
    Department of Vascular Surgery, UZ Gasthuisberg, Leuven, Belgium
    J Vasc Surg 33:188-90. 2001
    ..We report the case of a mother and fetus who both survived acute rupture of a renal artery aneurysm after treatment with ex situ repair and autotransplantation...
  57. ncbi Pregnancy outcomes in women with congenital heart disease
    Paul Khairy
    Boston Adult Congenital Heart Service, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 113:517-24. 2006
    ..Pregnant women with congenital heart disease are at increased risk for cardiac and neonatal complications, yet risk factors for adverse outcomes are not fully defined...
  58. ncbi Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder
    Jean Christophe Gris
    Hematology Laboratory, University Hospital, Nimes, France
    Blood 103:3695-9. 2004
    ..As there is no argument to prove that low-dose aspirin may have been deleterious, these results support enoxaparin use during such at-risk pregnancies...
  59. pmc Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study
    Marie Josée Martel
    Faculty of Pharmacy, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    BMJ 330:230. 2005
    ..To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women...
  60. ncbi Oocyte donation in patients with Turner's syndrome: a successful technique but with an accompanying high risk of hypertensive disorders during pregnancy
    D Bodri
    Clinica Eugin, c Entença 293 295, 08029 Barcelona and Hospital Clínic, IDIBAPS, University of Barcelona, Spain
    Hum Reprod 21:829-32. 2006
    ..Few data are available on pregnancy rate and obstetrical outcome after oocyte donation in Turner's syndrome patients. We conducted a retrospective analysis on the outcome of this subgroup...
  61. ncbi Preeclampsia and pregnancy loss in women with a history of venous thromboembolism and prophylactic low-molecular-weight heparin (LMWH) during pregnancy
    Guelay Alguel
    Department of Internal Medicine I, Medical University Vienna, Vienna, Austria
    Thromb Haemost 96:285-9. 2006
    ..There was a trend towards a higher risk of preeclampsia, and these women should be carefully monitored for this complication...
  62. ncbi Comparison between HELLP syndrome, chronic hypertension, and superimposed preeclampsia on chronic hypertension without HELLP syndrome
    Mehmet A Osmanagaoglu
    Department of Obstetrics and Gynecology, Medicine School of Karadeniz Technical University, 61080 Trabzon, Turkey
    J Perinat Med 32:481-5. 2004
    ..To compare perinatal outcome of patients with HELLP syndrome to that of patients with chronic hypertension and superimposed preeclampsia on chronic hypertension without HELLP syndrome...
  63. ncbi Effect of varying doses of fentanyl with low dose spinal bupivacaine for caesarean delivery in patients with pregnancy-induced hypertension
    K Jain
    Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Obstet Anesth 13:215-20. 2004
    ....
  64. ncbi Impact of pregnancy on the outcome of kidney transplantation
    N Kashanizadeh
    Nephrology and Urology Research Center NURC, Baqiyatallah Medical Sciences University, Tehran, Iran
    Transplant Proc 39:1136-8. 2007
    ..We, thus, compared two groups of kidney transplant recipients in terms of patient survival and allograft function: those who did versus did not conceive posttransplant...
  65. ncbi [Vascular complications and their effect on fetal-maternal outcome and therapeutic approach in diabetic women]
    Ewa Wender-Ozegowska
    Klinika Połoznictwa i Chorób Kobiecych, Katedry Ginekologii i Połoznictwa AM im K Marcinkowskiego w Poznaniu
    Ginekol Pol 75:385-96. 2004
    ..The aim of this study was to discuss the update guidelines for managing diabetic patients with vascular complications before and during the course of pregnancy...
  66. ncbi Associations of prepregnancy cardiovascular risk factors with the offspring's birth weight
    Pal R Romundstad
    Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway
    Am J Epidemiol 166:1359-64. 2007
    ..These findings suggest that low as well as high birth weight of the offspring may indicate increased cardiovascular risk for the mother...
  67. ncbi [Maternal and perinatal prognosis of pregnancy with chronic hypertension and analysis of associated factors]
    Yu Sun
    Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
    Zhonghua Fu Chan Ke Za Zhi 42:434-7. 2007
    ..To analyze the pregnant outcome of women with chronic hypertension, and to investigate the high risk factors associated with harmful maternal and perinatal prognosis...
  68. ncbi Outcome of pregnancy after organ transplantation: a retrospective survey in Italy
    Roberto Miniero
    Department of Paediatrics, University of Turin, Ospedale San Luigi di Orbassano, Reg Gonzole 10, 10043, Orbassano, Italy
    Transpl Int 17:724-9. 2005
    ..According to our previous experience, our study shows that patients who have undergone organ transplantation can give birth to healthy infants as long as they are monitored accurately during pregnancy...
  69. ncbi Acute coronary syndrome and preeclampsia
    Sepideh Nabatian
    Department of Cardiology, Lutheran General Hospital, Park Ridge, Illinois 60068, USA
    Obstet Gynecol 106:1204-6. 2005
    ..Approximately 150 cases of myocardial infarction during pregnancy have been documented in the literature worldwide (predominantly anterior wall). However, elevated troponin levels have been reported in patients with preeclampsia...
  70. ncbi Perinatal outcomes, blood pressure patterns and risk assessment of superimposed preeclampsia in mild chronic hypertensive pregnancy
    Stefano Raffaele Giannubilo
    Department of Obstetrics and Gynecology, Marche Polytechnic University at Salesi Hospital, via Corridoni 11, 60123 Ancona, Italy
    Eur J Obstet Gynecol Reprod Biol 126:63-7. 2006
    ..Assessment of perinatal outcomes, blood pressure (BP) patterns and risk of superimposed preeclampsia in a population with mild chronic hypertension...
  71. ncbi Invited commentary: Timing and types of cardiovascular risk factors in relation to offspring birth weight
    Roberta B Ness
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Epidemiol 166:1365-7. 2007
    ..Without all such time points, life course effects will remain only partially understood. It is hoped that studies such as the forthcoming National Children's Study will generate critical understanding of this issue...
  72. ncbi [High plasmatic androgen levels in women affected with pregnancy-induced hypertension]
    Donatella Gerulewicz-Vannini
    Servicio de Ginecologia y Obstetricia, Hospital General Dr José Gregorio Hernández
    Rev Invest Clin 58:228-33. 2006
    ....
  73. ncbi Effect of preeclampsia on blood pressure in newborn very low birth weight infants
    Jyothi Swarup
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 24:223-34. 2005
    ..To test the hypothesis that very low birth infants born to mothers with preeclampsia have higher blood pressure over the first week of life than infants whose mothers did not have preeclampsia...
  74. ncbi Pregnancy in women with Type 2 diabetes: who takes metformin and what is the outcome?
    R C E Hughes
    Department of Medicine, Auckland, New Zealand
    Diabet Med 23:318-22. 2006
    ..To review pregnancy outcomes in women with Type 2 diabetes (Type 2 DM), comparing women treated with those not treated with metformin...
  75. doi What matters in preeclampsia are the associated adverse outcomes: the view from Canada
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Opin Obstet Gynecol 20:110-5. 2008
  76. doi Hypertensive disorders of pregnancy: a UK-based perspective
    Manju Chandiramani
    King s College London, Division of Reproduction and Endocrinology, London, UK
    Curr Opin Obstet Gynecol 20:96-101. 2008
  77. pmc Chronic hypertension related to risk for preterm and term small for gestational age births
    Janet M Catov
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh Pennsylvania, USA
    Obstet Gynecol 112:290-6. 2008
    ..To identify factors associated with SGA that may involve a placental pathogenesis, we related chronic hypertension and other maternal factors that may be markers of endothelial dysfunction to preterm compared with term SGA births...
  78. ncbi Relation of parity to pregnancy outcome in a rural community in Zimbabwe
    F M Majoko
    Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe
    Afr J Reprod Health 8:198-206. 2004
    ..48; 95% 1.31- 1.67). In conclusion, nulliparous women had an increased risk of pregnancy complications. High parity women with no previous complicated pregnancy were at low risk of complications...
  79. ncbi Antihypertensive therapy in patients with pre-eclampsia: A prospective randomised multicentre study comparing dihydralazine with urapidil
    Juergen R Wacker
    Department of Obstetrics and Gynecology Bruchsal, Furst Stirum Klinik Bruchsal, Teaching Hospital of the University of Heidelberg, Gutleutstrasse 1 14, D 76646 Bruchsal, Baden Wuerttemberg, Germany
    Eur J Obstet Gynecol Reprod Biol 127:160-5. 2006
    ..Another particularly effective and better tolerable antihypertensive is urapidil. Yet only a few studies on limited patient collectives have been published on the clinical experience with urapidil in PIH...
  80. ncbi Nutrient intake and hypertensive disorders of pregnancy: Evidence from a large prospective cohort
    C D Morris
    Division of Medical Informatics and Outcomes Research, Oregon Health Sciences University, USA
    Am J Obstet Gynecol 184:643-51. 2001
    ..CONCLUSION: We found no evidence in this study for a significant association of hypertensive disorders of pregnancy with any of the 23 nutrients measured...
  81. ncbi Hypertensive disorders of pregnancy in women with Type 1 and Type 2 diabetes
    T Cundy
    Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland and, Diabetes Pregnancy Clinic, National Women s Hospital, Auckland, New Zealand
    Diabet Med 19:482-9. 2002
    ..The aim of this study was to compare the incidence and outcomes of, and risk factors for, hypertension in pregnancy in women with Type 1 and Type 2 diabetes...
  82. ncbi Hypertension in pregnancy and preeclampsia. Knowledge and clinical practice among obstetrician-gynecologists
    John T Repke
    Department of Obstetrics and Gynecology, University of Nebraska Medical Center, 983255 Nebraska Medical Center, Omaha, NE 68198 3255, USA
    J Reprod Med 47:472-6. 2002
    ..To examine the knowledge and practice patterns of obstetrician-gynecologists concerning management of hypertensive disorders of pregnancy...
  83. ncbi Anti-hypertensive drugs in pregnancy and fetal growth: evidence for "pharmacological programming" in the first trimester?
    Helen Bayliss
    Department of Obstetrics, Good Hope Hospital, NHS Trust, Rectory Road, Sutton Coldfield, B75 7RR, UK
    Hypertens Pregnancy 21:161-74. 2002
    ..To determine the timing and exact nature of the effect of the drug atenolol upon fetal growth. Also to discover if the reduction in fetal growth is due to superimposed pre-eclampsia or any other confounding variable...
  84. ncbi The impact of parity on the incidence of HELLP syndrome and small for gestational age infants in hypertensive pregnant women
    Keith P Williams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA
    J Obstet Gynaecol Can 24:485-9. 2002
    ....
  85. ncbi Prepidil compared to Propess for cervical ripening
    A Vollebregt
    Department of Obstetrics and Gynaecology, Spaarne Ziekenhuis Haarlem, Afdeling Verloskunde en Gynaecologie, Postbus 1644, 2003 Haarlem BR, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 104:116-9. 2002
    ..To compare the efficacy and safety of intracervical PGE(2) gel (Prepidil) with intravaginal PGE(2) insert (Propess) in cervical ripening and induction of labour...
  86. ncbi Association between fetal nuchal translucency thickness in first trimester and subsequent gestational hypertension and preeclampsia
    Ming Song Tsai
    Prenatal Diagnosis Center, Cathay General Hospital, Taipei, Taiwan
    Prenat Diagn 22:747-51. 2002
    ..However, the sensitivity of fetal NT measurement in first trimester is not sufficient as a single marker for predicting the pregnant women at risk for subsequent PAH...
  87. ncbi Factors influencing the obstetric and perinatal outcome after oocyte donation
    Galit Sheffer-Mimouni
    Departments of Obstetrics and Gynecology, The Lis Maternity Hospital, 6 Weizman St, Tel Aviv 46427, Israel
    Hum Reprod 17:2636-40. 2002
    ..We evaluated interactions between perinatal outcome after oocyte donation and various maternal factors...
  88. ncbi Prognostic value of absolute versus relative rise of blood pressure in pregnancy
    He Onah
    Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
    Afr J Reprod Health 6:32-40. 2002
    ....
  89. ncbi Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches
    Merja Vainio
    Department of Obstetrics and Gynaecology Tampere University Hospital, Finland
    BJOG 109:161-7. 2002
    ....
  90. ncbi Impact of preeclampsia and gestational hypertension on birth weight by gestational age
    Xu Xiong
    Department of Obstetrics and Gynecology, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    Am J Epidemiol 155:203-9. 2002
    ..This finding does not endorse the currently held theory that reduced uteroplacental perfusion is the unique pathophysiologic process in preeclampsia...
  91. ncbi The renin-aldosterone system during normal and hypertensive pregnancy
    A Elsheikh
    1st Department of Obstetrics and Gynecology, University of Athens, Alexandra Maternity Hospital, Greece
    Arch Gynecol Obstet 264:182-5. 2001
    ..Thus, we conclude that aldosterone biology seems to be directly or indirectly involved in the etiology of gestational hypertension independently of renin levels...
  92. ncbi Fetal loss rate associated with cordocentesis at midgestation
    T Tongsong
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand
    Am J Obstet Gynecol 184:719-23. 2001
    ..However, there were no significant differences in other obstetric complications between the study and control groups. CONCLUSION: The incremental fetal loss rate associated with cordocentesis at midgestation was about 1.4%...
  93. ncbi Mild gestational hypertension remote from term: progression and outcome
    J R Barton
    Maternal-Fetal Medicine, Central Baptist Hospital, Lexington, Kentucky 40503, USA
    Am J Obstet Gynecol 184:979-83. 2001
    ..6%. The development of proteinuria is associated with an earlier gestational age at delivery, lower birth weight, and an increased incidence of small-for-gestational age newborns...
  94. ncbi Doppler ultrasound screening predicts recurrence of poor pregnancy outcome in subsequent pregnancies, but not the recurrence of PIH or preeclampsia
    M W Aardema
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Perinatal Medicine, University Hospital Groningen, Groningen, The Netherlands
    Hypertens Pregnancy 19:281-8. 2000
    ..In contrast, gestational hypertension and preeclampsia with normal pregnancy outcome were not significantly predicted by uterine artery screening...
  95. ncbi The myth of transient hypertension: descriptor or disease process?
    D A Terrone
    Department of Obstetrics and Gynecology, Saint Barnabas Medical Center, Livingston, New Jersey, USA
    Am J Perinatol 18:73-7. 2001
    ..Transient hypertension occurs more often than expected, however, it appears to be of limited clinical significance...
  96. ncbi The prevalence of pre-eclampsia and obstetric outcome in pregnancies of normotensive and hypertensive women attending a hospital specialist clinic
    C Lydakis
    University Department of Medicine, City Hospital, Birmingham
    Int J Clin Pract 55:361-7. 2001
    ..The high prevalence of PE in chronic hypertensive women (16.0%) was not statistically significant to that of normotensive women (11.9%), reflecting the referral selection of 'high risk' normotensive women to our clinic...
  97. ncbi Obstetrical intervention rates and maternal and neonatal outcomes of women with gestational hypertension
    E N Gofton
    Department of Obstetrics and Gynecology, St. Joseph's Health Care, Lawson Health Research Institute, University of Western Ontario, London, ON, Canada
    Am J Obstet Gynecol 185:798-803. 2001
    ..CONCLUSION: Women with gestational hypertension had obstetrical intervention rates much higher than control subjects and similar to those with preeclampsia and chronic hypertension...
  98. ncbi Obstetric causes for delivery of very-low-birth-weight babies at Tygerberg Hospital
    E S Odendaal
    Department of Obstetrics and Gynecology, Tygerberg Hospital, W Cape, South Africa
    S Afr Med J 93:61-4. 2003
  99. ncbi Chronic hypertension in pregnancy
    J C Livingston
    Prenatal Diagnostic Center, Carilion Health System, Roanoke, VA 24013, USA
    Minerva Ginecol 55:1-13. 2003
    ..Fetal complications include prematurity, low birth weight, and perinatal death. Careful antepartum, intrapartum and postpartum management of women with high-risk chronic hypertension in pregnancies may reduce morbidity and mortality...
  100. ncbi A survey of canadian practitioners regarding diagnosis and evaluation of the hypertensive disorders of pregnancy
    M Caetano
    Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada
    Hypertens Pregnancy 23:197-209. 2004
    ..How Canadian practitioners are diagnosing and managing the hypertensive disorders of pregnancy (HDP), particularly in relation to the 1997 recommendations published by the Canadian Hypertension Society (CHS), is not known...
  101. ncbi Moderate alcohol drinking and risk of preterm birth
    F Parazzini
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milano, Italy
    Eur J Clin Nutr 57:1345-9. 2003
    ..We have analysed the association between alcohol drinking before and during the three trimesters of pregnancy and risk of preterm birth of babies with normal weight for gestational age or with low weight for gestational age (SGA)...

Research Grants73

  1. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2005
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  2. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2001
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  3. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2002
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  4. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2003
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  5. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2007
    ....
  6. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  7. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2006
    ....
  8. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2004
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  9. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2006
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. [unreadable] [unreadable]..
  10. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2005
    ....
  11. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2010
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  12. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  13. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2009
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  14. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 1999
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  15. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2008
    ....
  16. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2010
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  17. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2009
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  18. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2000
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  19. Women's Careers in the Medical Sciences and Family Friendly Policies
    AMPARO C contact VILLABLANCA; Fiscal Year: 2010
    ....
  20. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  21. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2007
    ..in renal medullary production of 20-HETE; 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats [unreadable] [unreadable]..
  22. Role of VEGF in Neonatal Pulmonary Hypertension
    Theresa Grover; Fiscal Year: 2007
    ..These studies will provide an integrated approach to the hypothesis, incorporating whole animal physiology coupled with molecular and cellular studies. ..
  23. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2006
    ..in renal medullary production of 20-HETE; 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats [unreadable] [unreadable]..
  24. Inflammation and Ovarian Cancer
    Clareann Bunker; Fiscal Year: 2008
    ..In particular, NSAID use may prove to be a potentially important chemopreventative for this often-fatal disease. ..
  25. Predoctoral Training Program in Reproductive, Perinatal & Pediatric Epidemiology
    Roberta Ness; Fiscal Year: 2008
    ..At the University of Pittsburgh, the combination of outstanding potential students, didactic experiences, and mentorship will maximize the likelihood of producing future leaders in RPP epidemiology. ..
  26. Role of VEGF in Neonatal Pulmonary Hypertension
    Theresa Grover; Fiscal Year: 2008
    ..These studies will provide an integrated approach to the hypothesis, incorporating whole animal physiology coupled with molecular and cellular studies. ..
  27. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2008
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  28. Dietary Glycemic Load, Obesity, and Birth Defect Risks
    Martha Werler; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. Role of FGF-23 in Mineral Metabolism Across the Spectum of Chronic Kidney Disease
    Myles Wolf; Fiscal Year: 2007
    ....
  30. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2007
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  31. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  32. BURPPE:BU Reproductive, Perinatal, and Pediatric Epidemiology Training Program
    Martha Werler; Fiscal Year: 2007
    ....
  33. DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth
    Irina A Buhimschi; Fiscal Year: 2010
    ....
  34. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2002
    ....
  35. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2001
    ....
  36. Women's Careers in the Medical Sciences and Family Friendly Policies
    Amparo Villablanca; Fiscal Year: 2009
    ....
  37. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2003
    ....
  38. GENETIC MECHANISMS OF ESTROGEN ATHEROPROTECTION
    Amparo Villablanca; Fiscal Year: 2003
    ..Advances in our basic understanding of mechanisms of hormone action could lead to more effective strategies for treatment of coronary artery disease in both men and women. ..
  39. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 1991
    ....
  40. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2004
    ....
  41. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 1992
    ....
  42. Predoctoral Training Program in Reproductive, Perinatal & Pediatric Epidemiology
    Roberta Ness; Fiscal Year: 2007
    ..At the University of Pittsburgh, the combination of outstanding potential students, didactic experiences, and mentorship will maximize the likelihood of producing future leaders in RPP epidemiology. ..
  43. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
    ....
  44. GENETIC EXPRESSION OF RISK GENES IN HYPERTENSION
    ELLEN SEELY; Fiscal Year: 2001
    ....
  45. Immune System Gene Polymorphisms and Preterm Delivery
    Claudia Holzman; Fiscal Year: 2008
    ..abstract_text> ..
  46. HLA-ASSOCIATED FC RECEPTOR FUNCTION IN NORMALS AND SLE
    Jane Salmon; Fiscal Year: 1993
  47. FC RECEPTOR FUNCTION IN NORMALS AND SLE
    Jane Salmon; Fiscal Year: 1999
    ..to define subclasses of IgG deposited within glomeruli in lupus nephritis and their relationships to FcgRIIa alleles, autoantibodies, and induction of glomerular injury. ..
  48. Maternal-Fetal HLA Sharing and Risk of Preeclampsia
    Audrey Saftlas; Fiscal Year: 2001
    ..05. The proposed study may be the first to examine the effects of maternal-fetal HLA sharing in an adequately powered epidemiological framework. ..
  49. Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The multi-ethni
    BRYAN R contact KESTENBAUM; Fiscal Year: 2010
    ..Findings will help clarify optimal serum concentrations of phosphorous and vitamin D biomarkers with respect to cardiovascular health and inform clinical trials which target mineral metabolism to prevent and reduce CVD. ..
  50. Predictors of Pregnancy Outcome in SLE and APS
    Jane Salmon; Fiscal Year: 2003
    ..The identification of such surrogate markers in aPL and SLE patients may also prove generally applicable to anticipate complications during pregnancy in disease-free women. ..
  51. Neighborhood Disparities and Access to Cardiac Care
    Jing Fang; Fiscal Year: 2003
    ..This would be important for policy to eliminate the health disparity. ..
  52. CHARACTERIZING MICROFIBRIL ABNORMALITIES IN SCLERODERMA
    Dianna Milewicz; Fiscal Year: 2003
    ..The research proposed in this grant will determine the contribution of abnormalities in fibrillin-1-containing microfibrils to the activation of fibroblasts, which leads to the fibrosis that characterizes SSc. ..
  53. Conditioned Placebo Effects & Treatment of Hypertension
    Thomas Pickering; Fiscal Year: 2003
    ..The demonstration of a conditioned placebo effect that produces a sustained reduction of BP could result in more economical treatment with fewer side effects. ..
  54. Maternal-Fetal HLA Sharing and Risk of Preeclampsia
    Audrey Saftlas; Fiscal Year: 2002
    ..05. The proposed study may be the first to examine the effects of maternal-fetal HLA sharing in an adequately powered epidemiological framework. ..
  55. Regulation of Lung Sodium Channels
    Lucky Jain; Fiscal Year: 2001
    ..These experiments will improve our understanding of how lungs modulate alveolar fluid absorption, and help it devising therapeutic strategies to improve the process. ..
  56. Prevalence of FMRI Expansions in Movement Disorders
    Deborah Hall; Fiscal Year: 2007
    ..These illnesses represent an important public health problem as they cause morbidity and mortality in our aging population. ..
  57. CHARACTERIZING MICROFIBRIL ABNORMALITIES IN SCLERODERMA
    Dianna Milewicz; Fiscal Year: 2001
    ..The research proposed in this grant will determine the contribution of abnormalities in fibrillin-1-containing microfibrils to the activation of fibroblasts, which leads to the fibrosis that characterizes SSc. ..
  58. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2000
    ..These fundamental mechanistic studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy. ..
  59. Pharmacological Optimization of Poly-Drug Therapy in Traumatic Brain Injury
    Michael R Hoane; Fiscal Year: 2010
    ..This study will help to identify combinations of drugs that could be used to prevent the long-term effects. ..
  60. Phytoestrogen and Endogenous Estrogen Exposure and Risk of Stroke
    Xianglan Zhang; Fiscal Year: 2010
    ..Study results may contribute to the development of new strategies for the primary prevention of stroke. ..
  61. Pharmacological Optimization of Poly-Drug Therapy in Traumatic Brain Injury
    Gail Anderson; Fiscal Year: 2009
    ..This study will help to identify combinations of drugs that could be used to prevent the long-term effects. ..
  62. MANAGEMENT OF PATIENTS WITH SUSPECTED PULMONARY EMBOLISH
    Suman Rathbun; Fiscal Year: 2005
    ..abstract_text> ..
  63. Duke Center for Geospatial Medicine (RMI)
    Marie Lynn Miranda; Fiscal Year: 2006
    ..Using neural tube defects as a prototype health endpoint, we will develop a generalized framework for applying these methods to a wide variety of health endpoints, including autism, asthma, ADHD, and obesity. [unreadable] [unreadable]..
  64. RESEARCH ON SCOPE & CAUSES OF STILLBIRTH IN THE US
    DONALD COUSTAN; Fiscal Year: 2008
    ..abstract_text> ..
  65. NICHD Maternal Fetal Medicine Units Network
    DONALD COUSTAN; Fiscal Year: 2008
    ..WIH is also home to a Unit of the Neonatal Research Network. These attributes make the Brown/Women & Infants Unit a desirable candidate for funding renewal. ..
  66. Brown Medical School/WIHRI Dept of Ob/Gyn WRHR Program
    DONALD COUSTAN; Fiscal Year: 2007
    ..This multidisciplinary program will provide a new cadre of academic investigators who will further the scientific database and improve the health status of women. ..
  67. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Victor Tapson; Fiscal Year: 2003
    ..abstract_text> ..
  68. Brown University BIRCWH Career Development Program
    DONALD COUSTAN; Fiscal Year: 2006
    ..This interdisciplinary and cross-institutional program will provide a new cadre of academic investigators who will further the scientific database and improved the health status of women. ..
  69. Brown Medical School/WIHRI Dept of Ob/Gyn WRHR Program
    Joanna Cain; Fiscal Year: 2008
    ..This multidisciplinary program will provide a new cadre of academic investigators who will further the scientific database and improve the health status of women. ..