Summary: Infection in humans and animals caused by any fungus in the order Mucorales (e.g., Absidia, Mucor, Rhizopus etc.) There are many clinical types associated with infection of the central nervous system, lung, gastrointestinal tract, skin, orbit and paranasal sinuses. In humans, it usually occurs as an opportunistic infection in patients with a chronic debilitating disease, particularly uncontrolled diabetes, or who are receiving immunosuppressive agents. (From Dorland, 28th ed)
Publications276 found, 100 shown here
- Recent advances in the management of mucormycosis: from bench to bedsideBrad Spellberg
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, 1124 West Carson St, RB2, Torrance, CA 90502, USA
Clin Infect Dis 48:1743-51. 2009Recent therapeutic advances have the potential to improve outcomes of mucormycosis. Lipid formulations of amphotericin B (LFAB) have evolved as the cornerstone of primary therapy for mucormycosis...
- Nosocomial fungal infections: epidemiology, diagnosis, and treatmentJoshua Perlroth
Division of Infectious Diseases, Harbor University of California Los Angeles UCLA Medical Center, California 90502, USA
Med Mycol 45:321-46. 2007..Nevertheless, the mortality of nosocomial fungal infections remains high, and new therapeutic and preventative strategies are needed...
- Epidemiology and clinical manifestations of mucormycosisGeorge Petrikkos
National and Kapodistrian University of Athens, Attikon Hospital, Haidari, Athens, Greece
Clin Infect Dis 54:S23-34. 2012b>Mucormycosis is an emerging angioinvasive infection caused by the ubiquitous filamentous fungi of the Mucorales order of the class of Zygomycetes...
- The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hostsSarah P Georgiadou
Infectious Diseases Unit, Pathophysiology Department, Laikon General Hospital and Medical School, National and Kapodistrian University of Athens, Athens, Greece
Clin Infect Dis 52:1144-55. 2011..sign and reversed halo sign are most commonly associated with invasive pulmonary aspergillosis and pulmonary mucormycosis, respectively...
- Pathogenesis of mucormycosisAshraf S Ibrahim
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, University of California Los Angeles, 1124 W Carson St, Torrance, CA 90502, USA
Clin Infect Dis 54:S16-22. 2012b>Mucormycosis is a life-threatening infection that occurs in patients who are immunocompromised because of diabetic ketoacidosis, neutropenia, organ transplantation, and/or increased serum levels of available iron...
- Invasive mycoses: strategies for effective managementDimitrios P Kontoyiannis
Division of Internal Medicine, Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Am J Med 125:S25-38. 2012..often depends on a high index of suspicion, taking into account predisposing factors, host cues favoring mucormycosis, and local epidemiology...
- Mucormycosis caused by unusual mucormycetes, non-Rhizopus, -Mucor, and -Lichtheimia speciesMarisa Z R Gomes
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Microbiol Rev 24:411-45. 2011..Mucor, and Lichtheimia (formerly Absidia) species are the most common members of the order Mucorales that cause mucormycosis, accounting for 70 to 80% of all cases...
- Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: molecular mycologic perspectivesKyung J Kwon-Chung
Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Clin Infect Dis 54:S8-S15. 2012..was originally described as a convenient and inclusive name for 2 clinicopathologically different diseases, mucormycosis caused by members of Mucorales and entomophthoramycosis caused by species in the order Entomophthorales of ..
- Healthcare-associated mucormycosisBlandine Rammaert
Sorbonne Paris Cité, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, APHP, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, Paris Cedex 15, France
Clin Infect Dis 54:S44-54. 2012b>Mucormycosis is a severe emerging invasive fungal infection that occurs as a consequence of environmental exposure...
- Diabetes and mucormycosis: a complex interplayB Rammaert
Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Institut Imagine, AP HP, 149, rue des Sèvres, 75743 Paris Cedex 15, France
Diabetes Metab 38:193-204. 2012b>Mucormycosis is a life-threatening invasive fungal infection that arises particularly in diabetic patients with or without other underlying conditions such as haematological malignancies or the need for solid-organ transplantation...
- Pulmonary mucormycosisGeorgios Hamilos
Department of Internal Medicine, School of Medicine, University of Crete, Heraklion, Greece
Semin Respir Crit Care Med 32:693-702. 2011b>Mucormycosis (formerly zygomycosis) is a life-threatening opportunistic mycosis that infects a broad range of hosts with qualitative or quantitative defects in innate immunity, including patients with severe neutropenia, recipients of ..
- The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trialBrad Spellberg
Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor University of California Los Angeles UCLA Medical Center, Torrance, CA, USA
J Antimicrob Chemother 67:715-22. 2012Host iron availability is fundamental to mucormycosis pathogenesis. The combination of liposomal amphotericin B (LAmB) and deferasirox iron chelation therapy synergistically improved survival in diabetic mice with mucormycosis...
- Necrotizing cutaneous mucormycosis after a tornado in Joplin, Missouri, in 2011Robyn Neblett Fanfair
Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 367:2214-25. 2012b>Mucormycosis is a fungal infection caused by environmentally acquired molds. We investigated a cluster of cases of cutaneous mucormycosis among persons injured during the May 22, 2011, tornado in Joplin, Missouri.
- Primary gastrointestinal mucormycosis in an immunocompetent personB N Shiva Prasad
Department of Medicine, KMC, Manipal, Karnataka, India
J Postgrad Med 54:211-3. 2008In the past decade, mucormycosis has emerged as an important lethal infection in diabetics and other immunocompromised hosts...
- Usefulness of molecular biology performed with formaldehyde-fixed paraffin embedded tissue for the diagnosis of combined pulmonary invasive mucormycosis and aspergillosis in an immunocompromised patientVeronique Hofman
Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, 30 Avenue de la Voie Romaine, Nice, France
Diagn Pathol 5:1. 2010..We report a case of fatal necrotic pneumonia caused by combined pulmonary invasive mucormycosis and aspergillosis in a 66 year-old renal transplant recipient...
- Rhinocerebral mucormycosis: pathways of spreadSeid Mousa Sadr Hosseini
Department of Otolaryngology, Vali e Asr Hospital, Teheran University of Medical Sciences, Iran
Eur Arch Otorhinolaryngol 262:932-8. 2005Rhinocerebral mucormycosis is an invasive, opportunistic fungal infection usually seen in immunocompromised patients, and particularly in the setting of diabetes or immune deficiency...
- Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatmentR M Prabhu
Division of Infectious Diseases Division of Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Microbiol Infect 10:31-47. 2004..Rhizomucor, Absidia, Apophysomyces, Cunninghamella and Saksenaea) cause an angioinvasive infection called mucormycosis. Mucormycosis presents with rhino-orbito-cerebral, pulmonary, disseminated, cutaneous, or gastrointestinal ..
- Increasing incidence of zygomycosis (mucormycosis), France, 1997-2006Dounia Bitar
Infectious Diseases Department, Institut de Veille Sanitaire, Saint Maurice, France
Emerg Infect Dis 15:1395-401. 2009..Incidence also increased in the population of patients with diabetes mellitus. We conclude that observed trends reflect a genuine increase of zygomycosis cases in at-risk populations...
- Prolonged survival of an HIV-infected subject with severe lymphoproliferative disease and rhinocerebral mucormycosisMarco Bongiovanni
J Antimicrob Chemother 60:192-3. 2007
- Treatment of 21 cases of invasive mucormycosis with amphotericin B colloidal dispersionR Herbrecht
Département d Onco Hématologie, Hopital de Hautepierre, Strasbourg, France
Eur J Clin Microbiol Infect Dis 20:460-6. 2001The aim of this study was to review the characteristics and outcome of 21 patients with invasive mucormycosis treated with amphotericin B colloidal dispersion (ABCD) in five phase I and phase II studies...
- Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatmentAshraf S Ibrahim
Division of Infectious Diseases, Harbor UCLA Medical Center, 1124 West Carson St, RB2, Torrance, CA 90502, USA
Curr Opin Infect Dis 21:620-5. 2008b>Mucormycosis is an increasingly common fungal infection with an unacceptably high mortality despite first-line antifungal therapy. Iron acquisition is a critical step in the causative organisms' pathogenetic mechanism...
- Cytomegalovirus vasculitis and mucormycosis coinfection in late-stage HIV/AIDSJyoti S Samant
Department of Internal Medicine, Section of Infectious Diseases, Mercer University, School of Medicine, Macon, Georgia 31201, USA
Am J Med Sci 333:122-4. 2007Case reports have previously been published describing various complications of cytomegalovirus (CMV) and mucormycosis in patients with HIV/AIDS...
- Presentation and outcome of rhino-orbital-cerebral mucormycosis in patients with diabetesA Bhansali
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Postgrad Med J 80:670-4. 2004To report presentation and outcome of rhino-orbital-cerebral mucormycosis (ROCM) exclusively in patients with diabetes mellitus.
- Acute optic nerve infarction demonstrated by diffusion-weighted imaging in a case of rhinocerebral mucormycosisS Mathur
Department of Radiology, University of Illinois Medical Center at Chicago, Chicago, Ill, USA
AJNR Am J Neuroradiol 28:489-90. 2007SUMMARY: A 60-year-old woman developed right-eye vision loss secondary to rhinocerebral mucormycosis. Routine MR imaging sequences including enhanced MR imaging showed normal optic nerves, but a diffusion-weighted sequence and apparent ..
- Mucormycosis in systemic lupus erythematosusChi Chiu Mok
Departments of Medicine, Microbiology, Radiology, and Pathology, Tuen Mun Hospital, Hong Kong, China
Semin Arthritis Rheum 33:115-24. 2003To describe a case of mucormycosis in systemic lupus erythematosus (SLE) and to review other patients reported in the English literature.
- The iron chelator deferasirox protects mice from mucormycosis through iron starvationAshraf S Ibrahim
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
J Clin Invest 117:2649-57. 2007b>Mucormycosis causes mortality in at least 50% of cases despite current first-line therapies. Clinical and animal data indicate that the presence of elevated available serum iron predisposes the host to mucormycosis...
- Apophysomyces elegans: an emerging zygomycete in IndiaA Chakrabarti
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
J Clin Microbiol 41:783-8. 2003..The study highlights the epidemiology, clinical spectrum, and diagnosis of emerging A. elegans infections...
- Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitroAshraf S Ibrahim
Division of Infectious Diseases, St John s Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Bldg RB2, 1124 West Carson Street, Torrance, CA 90502, USA
Infect Immun 73:778-83. 2005..The fact that dead R. oryzae damage human endothelial cells may, in part, explain the lack of efficacy of fungicidal agents during clinical disease...
- Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosisAshraf S Ibrahim
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
J Infect Dis 198:1083-90. 2008..We sought to define the role of rhizoxin production by endosymbionts in the pathogenesis of mucormycosis. Endosymbiotic bacteria were identified by polymerase chain reaction in 15 (54%) of 28 clinical isolates of ..
- PCR based identification and discrimination of agents of mucormycosis and aspergillosis in paraffin wax embedded tissueR Bialek
Institute for Tropical Medicine, University Hospital Tubingen, Keplerstrasse 15, 72074 Tubingen, Germany
J Clin Pathol 58:1180-4. 2005..Invasive fungal infections are often diagnosed by histopathology without identification of the causative fungi, which show significantly different antifungal susceptibilities...
- Rhinocerebral mucormycosis in a boy with recurrent acute lymphoblastic leukemia: long-term survival with systemic antifungal treatmentGoetz Wehl
Department of Pediatrics, University of Innsbruck, Austria
J Pediatr Hematol Oncol 24:492-4. 2002Rhinocerebral mucormycosis is rare in hematologic malignancies and usually leads to death within weeks...
- Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patientsLeonardo Potenza
Section of Haematology, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy
Blood 118:5416-9. 2011..Three developed proven invasive mucormycosis (IM), 17 had infections of known origin but other than IM, and 8 never had fever during the period of ..
- Mucormycosis: its contemporary face and management strategiesHsin Yun Sun
Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
Lancet Infect Dis 11:301-11. 2011Several countries have seen rising frequencies of mucormycosis among patients with haematological disorders, malignancies, or diabetes mellitus, and among transplant recipients...
- Cytomegalovirus pneumonia with pulmonary mucormycosisVijaya V Mysorekar
Department of Pathology, M S Ramaiah Medical College, Bangalore, Karnataka, India
Indian J Pathol Microbiol 51:294-5. 2008..We describe a case of mixed opportunistic lung infection in the form of cytomegalovirus pneumonia and mucormycosis in a renal transplant recipient...
- Rapid susceptibility testing of medically important zygomycetes by XTT assayCharalampos Antachopoulos
Pediatric Oncology Branch, National Cancer Institute, CRC, Rm 1 5750, MSC 1100, 10 Center Drive, Bethesda, MD 20892, USA
J Clin Microbiol 44:553-60. 2006..These results support the use of the XTT method for rapid MIC determination for Zygomycetes...
- Mucormycosis, pseudallescheriasis, and other uncommon mold infectionsClifford Quan
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles UCLA Medical Center, Torrance, California 90502, USA
Proc Am Thorac Soc 7:210-5. 2010..In this review, we summarize current knowledge about non-Aspergillus mold infections of the chest, with a focus on risk factors, clinical features, diagnosis, and treatment...
- Mucormycosis-associated fungal infections in patients with haematologic malignanciesI O Kara
Department of Medical Oncology, Faculty of Medicine, Cukurova University, Turkey
Int J Clin Pract 63:134-9. 2009Among patients with haematologic disorders, mucormycosis most commonly occurs in those with acute leukaemia or lymphoma who have developed neutropenia due to malignancy or to chemotherapy, and in transplanted patients receiving ..
- Preliminary investigation into the prevalence of mucormycosis in the platypus (Ornithorhynchus anatinus) in three catchments in north-west TasmaniaJ W Macgregor
Conservation Medicine Program, School of Veterinary and Biomedical Sciences, Murdoch University, Western Australia, Australia
Aust Vet J 88:190-6. 2010To investigate the distribution and prevalence of mucormycosis in platypus (Ornithorhynchus anatinus) from the Inglis, Emu and Black-Detention catchment areas in north-west Tasmania.
- The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic miceMingfu Liu
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
J Clin Invest 120:1914-24. 2010b>Mucormycosis is a fungal infection of the sinuses, brain, or lungs that causes a mortality rate of at least 50% despite first-line therapy...
- Voriconazole pre-exposure selects for breakthrough mucormycosis in a mixed model of Aspergillus fumigatus-Rhizopus oryzae pulmonary infectionRussell E Lewis
Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, TX, USA
Virulence 2:348-55. 2011b>Mucormycosis is an uncommon fungal infection that has been increasingly reported in severely immunocompromised patients receiving Aspergillus-active antifungals...
- Rhinocerebral mucormycosis in a child with acute lymphoblastic leukemia: a case reportGheorghe Popa
Department of Pediatric Oncology, Pediatric Clinic No 2, University of Medicine and Pharmacy, Iuliu Hatieganu Cluj Napoca, Romania
J Pediatr Hematol Oncol 30:163-5. 2008b>Mucormycosis is a life-threatening fungal infection in patients with predisposing conditions.
- Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosisCaitlin Reed
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, CA, USA
Clin Infect Dis 47:364-71. 2008It has been axiomatic that echinocandins (e.g., caspofungin) are ineffective against mucormycosis. However, on the basis of preclinical data, we recently began treating rhino-orbital-cerebral mucormycosis (ROCM) with combination polyene-..
- Mandibular mucormycosis in immunocompromised patients: report of 2 cases and review of the literatureMutan Hamdi Aras
Department of Oral and Maxillofacial Surgery, Gaziantep University, Gaziantep, Turkey
J Oral Maxillofac Surg 70:1362-8. 2012b>Mucormycosis, also known as zygomycosis, is an opportunistic fungal infection caused by a series of fungi in the Mucorales family in people with immune disorders...
- Efficacy of caspofungin in neutropenic and corticosteroid-immunosuppressed murine models of invasive pulmonary mucormycosisRussell E Lewis
Division of Clinical and Experimental Pharmacology, University of Houston College of Pharmacy, Houston, Texas, USA
Antimicrob Agents Chemother 55:3584-7. 2011..CFG administered at 16 mg/kg/day was not significantly better than a saline control for treatment of invasive pulmonary mucormycosis (IPM) in either neutropenic or corticosteroid-immunosuppressed animals.
- Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009Sarah P Hammond
Division of Infectious Diseases, Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
Antimicrob Agents Chemother 55:5018-21. 2011Mortality due to mucormycosis is high. We assessed clinical characteristics and mortality among stem cell transplant and hematologic malignancy patients diagnosed with mucormycosis from 2001 to 2009...
- Apophysomyces elegans - renal mucormycosis in a healthy host: a case report from south IndiaA J Thomas
Department of Urology, Christian Medical College, Vellore 632 004, Tamil Nadu, India
Indian J Med Microbiol 26:269-71. 2008..Ureterorenoscopy was performed, fungal elements removed and pathological confirmation obtained. The patient subsequently underwent nephrectomy after treatment with amphotericin B. He made an uneventful recovery...
- Gangrenous cutaneous mucormycosis caused by Rhizopus oryzae: a case report and review of primary cutaneous mucormycosis in China over Past 20 yearsHoumin Li
Department of Dermatology, Peking University, People s Hospital, Beijing, 100044, People s Republic of China
Mycopathologia 176:123-8. 2013Cutaneous mucormycosis is a rare opportunistic infection caused by zygomycetes that can be rapidly fatal if unrecognized...
- Update on mucormycosis pathogenesisAshraf S Ibrahim
aDivision of Infectious Diseases, Harbor University of California Los Angeles Medical Center bSt John s Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance cDavid Geffen School of Medicine at UCLA, Los Angeles, California dDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Curr Opin Infect Dis 26:508-15. 2013b>Mucormycosis is an increasingly common fungal infection with unacceptably high mortality...
- How does antifungal pharmacology differ for mucormycosis versus aspergillosis?Russell E Lewis
Department of College of Pharmacy, The University of Houston, TX 77030, USA
Clin Infect Dis 54:S67-72. 2012..mortality rates remain relatively unchanged for less common, but highly aggressive, mold infections such as mucormycosis. Recent genome sequencing of Rhizopus oryzae revealed evidence of a whole-genome duplication event during the ..
- Emerging therapeutic options in fulminant invasive rhinocerebral mucormycosisKathrin Scheckenbach
Department of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
Auris Nasus Larynx 37:322-8. 2010Five cases of rhinocerebral mucormycosis (RCM) with different courses of illness and outcomes also due to different therapeutical strategies including Posaconazole as a new therapeutic option are described...
- The "Black Turbinate" sign: An early MR imaging finding of nasal mucormycosisS Safder
Department of Radiology, West Virginia University Hospital, Morgantown, USA
AJNR Am J Neuroradiol 31:771-4. 2010Rhinocerebral mucormycosis is a rare angioinvasive fungal infection that has a strong predilection for patients with poorly controlled diabetes and immunosuppression...
- Early clinical and laboratory diagnosis of invasive pulmonary, extrapulmonary, and disseminated mucormycosis (zygomycosis)Thomas J Walsh
Transplantation Oncology Infectious Diseases Program, Weill Cornell University Medical Center, 1300 York Avenue, New York, NY 10065, USA
Clin Infect Dis 54:S55-60. 2012Early diagnosis of invasive mucormycosis is important for timely therapeutic intervention, improved survival, and reduced morbidity...
- Combination therapy for mucormycosis: why, what, and how?Brad Spellberg
Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, University of California at Los Angeles, 1124 West Carson St, Torrance, CA 90502, USA
Clin Infect Dis 54:S73-8. 2012The high mortality rate of mucormycosis with currently available monotherapy, particularly in hematology patients, has stimulated interest in studying novel combinations of antifungal agents to determine whether superior outcomes might be ..
- Fatal primary cutaneous zygomycosis caused by Saksenaea vasiformis: case report and review of literatureRobin Kaushik
Department of General Surgery, Government Medical College Hospital, Chandigarh, India
Surg Infect (Larchmt) 13:125-9. 2012..Primary cutaneous zygomycosis caused by Saksenaea vasiformis is rare. Such infections usually are not suspected, and delay in their diagnosis and treatment results in a poor outcome...
- Evidence implicating Thamnostylum lucknowense as an etiological agent of rhino-orbital mucormycosisImmaculata Xess
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
J Clin Microbiol 50:1491-4. 2012In this report, we present a case of rhino-orbital mucormycosis in a 57-year-old female with poorly controlled diabetes mellitus...
- Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3)Anna Skiada
Department of Propaedeutic Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece
Haematologica 98:492-504. 2013b>Mucormycosis is an emerging cause of infectious morbidity and mortality in patients with hematologic malignancies. However, there are no recommendations to guide diagnosis and management...
- Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosisRussell E Lewis
Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Infect Dis 207:834-41. 2013We hypothesized that tacrolimus, an inhibitor of the calcineurin pathway, would enhance the in vivo activity of posaconazole against Rhizopus oryzae, the Mucorales species most commonly associated with mucormycosis.
- Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case reportA A Cagatay
Department of Clinical Bacteriology and Infectious Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
BMC Infect Dis 1:22. 2001b>Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia...
- Rhinocerebral mucormycosis in an 11-year-old boyM Gessesse
Department of Paediatrics, Yekatit 12 Hospital, P.O. Box 257, Addis Ababa, Ethiopia
Ethiop Med J 39:341-8. 2001A patient with diabetic ketoacidosis admitted for treatment developed features characteristic of rhinocerebral mucormycosis, confirmed by histopathologic examination, is presented...
- Long-term posaconazole treatment and follow-up of rhino-orbital-cerebral mucormycosis in a diabetic girlLuigi Tarani
Pediatric Department, University La Sapienza, Rome, Italy
Pediatr Diabetes 10:289-93. 2009..is safe and beneficial in treatment and prevention of relapses of, otherwise fatal, central nervous system mucormycosis. Mucormycosis is a very rare opportunistic mycotic infection of diabetic children...
- Rhinocerebral mucormycosis in an adolescent with type 1 diabetes mellitus: case reportR Ganesh
Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai, India
Ann Trop Paediatr 28:297-300. 2008Rhinocerebral mucormycosis is a severe opportunistic infection affecting immunocompromised patients. A 14-year-old boy with rhino-orbito-cerebral mucormycosis and type 1 diabetes is described...
- In vitro interaction of caspofungin and immunosuppressives against agents of mucormycosisManish Thakur
Department of Medicine, Wayne State University, Detroit, MI, USA
J Antimicrob Chemother 66:2312-4. 2011b>Mucormycosis is a rare but refractory mycosis with high mortality. Few therapeutic options are available and novel strategies are needed...
- The reversed halo sign as the initial radiographic sign of pulmonary zygomycosisA Busca
Department of Hematology, San Giovanni Battista Hospital, Turin, Italy
Infection 40:77-80. 2012..This case supports earlier observations that RHS may be an early radiological sign of zygomycosis, facilitating an aggressive diagnostic strategy...
- Rhinocerebral mucormycosis in patients without predisposing medical conditions: a review of the literatureH Elinav
Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Clin Microbiol Infect 15:693-7. 2009Rhinocerebral mucormycosis is a rare disease, affecting almost exclusively patients with known predisposing conditions such as diabetes mellitus, immunocompromised status, haemochromatosis or major trauma...
- Rhinocerebral mucormycosis in a patient with cirrhosis and chronic renal failureStavroula Georgopoulou
Henry Dunant Hospital, 107 Mesogeion Ave, 11526, Athens, Greece
Hepatogastroenterology 50:843-5. 2003b>Mucormycosis is an opportunistic fungal infection caused by Mucorales. The disease is uncommon and produces serious and rapidly fatal infection in diabetic or immunocompromised patients...
- Treatment of rhinocerebral mucormycosis by combination of endoscopic sinus debridement and amphotericin BI Alobid
Department of Otorhinolaryngology, Hospital Clinic of Barcelona, Spain
Am J Rhinol 15:327-31. 2001Rhinocerebral mucormycosis (RCM) is an aggressive fungal infection with a high mortality rate. It frequently develops in patients with uncontrolled diabetes mellitus or immunocompromised patients...
- Fatal strokes in patients with rhino-orbito-cerebral mucormycosis and associated vasculopathyPeterus Thajeb
Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan, ROC
Scand J Infect Dis 36:643-8. 2004..B and surgical debridement of paranasal sinuses in 6 pathologically verified cases of rhino-orbito-cerebral mucormycosis (ROCM). All patients had unnoticed type-2 diabetes mellitus without ketoacidosis...
- Peritoneal mucormycosis in a patient on CAPDS Nayak
Perit Dial Int 27:216-7. 2007
- Successful treatment of pulmonary mucormycosis in a renal transplant recipient with limited pulmonary reserve by combined medical and surgical therapyJordan Y Z Li
Department of Nephrology and Transplantation Services, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
Heart Lung Circ 18:226-8. 2009b>Mucormycosis is a rare opportunistic fungal infection in renal transplant recipients which is associated with exceedingly high mortality when inadequately treated...
- Necrosis of nasal cartilage due to mucormycosis in a patient with severe congenital neutropenia due to HAX1 deficiencyA Fahimzad
Pediatric Infections Research Center, Mofid Children Hospital, Shaheed Beheshti University of Sciences, Tehran, Iran
J Investig Allergol Clin Immunol 18:469-72. 2008..The clinical course was complicated by necrosis of the nasal cartilage due to mucormycosis. Molecular studies revealed a homozygous germline HAX1 mutation...
- Mucormycosis spondylodiscitis after lumbar disc punctureFei Chen
Department of Spine Surgery, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, China
Eur Spine J 15:370-6. 2006Vertebral osteomyelitis due to mucormycosis is a rare but fulminant and fatal disease. Only one case has been reported in literature, with postmortem diagnosis...
- Rhino-orbito-cerebral mucormycosis, a retrospective study of 7 casesPablo Santos Gorjón
Servicio de Otorrinolaringología y Patología Cérvico facial, Hospital Universitario de Salamanca, Salamanca, Espana
Acta Otorrinolaringol Esp 61:48-53. 2010b>Mucormycosis is an opportunistic fungal infection caused by fungi of the Mucorales order. It has a low incidence and is a potentially lethal infection which generally affects patients who are immunocompromised due to systemic disease...
- How I treat mucormycosisDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 118:1216-24. 2011Unlike invasive aspergillosis, the prognosis and outcome of hematologic malignancy patients who develop invasive mucormycosis have not significantly improved over the past decade as a majority of patients who develop the infection still ..
- Isolated pulmonary mucormycosis in an apparently normal host: a case reportA Butala
Department of Medicine, St Mary s Hospital and Interfaith Medical Center, Brooklyn, NY 11213, USA
J Natl Med Assoc 87:572-4. 1995b>Mucormycosis is a rare fungal disease commonly affecting individuals with diabetes mellitus, hematological malignancy, and immune deficiency. Isolated pulmonary mucormycosis is extremely rare...
- Isolated renal mucormycosis in childrenLi Jianhong
Department ofPediatric Surgery, Second University Hospital of Medical College, Shantou University, Guangdong Province, China
J Urol 171:387-8. 2004
- Fatal rhino-orbito-cerebral infection caused by Saksenaea vasiformis in an immunocompetent individual: first case report from IndiaV P Baradkar
Department of Microbiology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India
Indian J Med Microbiol 26:385-7. 2008..We believe this case to be the first case of rhino-orbito-cerebral infection due to Saksenaea vasiformis and that of second case in an immunocompetent patient in the world...
- Risk factors for mortality in patients with mucormycosisBrad Spellberg
Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor University of California Los Angeles UCLA Medical Center, Los Angeles, CA, USA
Med Mycol 50:611-8. 2012Optimal clinical care and clinical investigation of patients with mucormycosis are limited by absence of controlled trials, and absence of well-defined predictors of mortality or clinical response...
- A global analysis of mucormycosis in France: the RetroZygo Study (2005-2007)F Lanternier
Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, 25 rue du Dr Roux, Paris, France
Clin Infect Dis 54:S35-43. 2012b>Mucormycosis is a deadly invasive fungal infection whose characteristics are only partially understood.
- Fatal cellulitis caused by Apophysomyces elegansA J Kindo
Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai 600 116, India
Indian J Med Microbiol 25:285-7. 2007..Patient developed angioinvasion, severe cellulitis and finally succumbed to the infection three weeks after admission...
- Hepatic mucormycosis mimicking hilar cholangiocarcinoma: a case report and literature reviewKe Wei Li
Division of Liver Transplantation, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
World J Gastroenterol 16:1039-42. 2010b>Mucormycosis is a rare but invasive opportunistic fungal infection associated with a high mortality rate, and normally occurs in immunocompromised patients...
- [Non-fatal disseminated mucormycosis in a solid organ transplant]C Minet
Unité de pneumologie, pole de médecine aiguë communautaire, CHU de Grenoble, France
Rev Mal Respir 26:998-1002. 2009b>Mucormycosis is a rare fungal infection occurring most frequently in immunocompromised patients. The pathogens are filamentous fungi, order of Mucorales. Disseminated mucormycosis is a severe, life treating disease...
- Massive lower gastrointestinal bleeding secondary to colonic mucormycosisJ Anand
Gastroenterology Unit, Department of Medicine, RIPAS Hospital, Bandar Seri Begawan BA 1710, Brunei Darussalam
Med J Malaysia 66:266-7. 2011..She later developed massive lower gastrointestinal bleeding secondary to colonic mucormycosis. Her condition deteriorated rapidly and she died of septicemia...
- [Necrotizing fasciitis in an immunocompetent patient caused by Apophysomyces elegans]Carmen Elena Ruiz
Servicio de Cirugia, Hospital Pablo Tobon Uribe, Medellin, Colombia
Biomedica 24:239-51. 2004..Later this progressed to the right lumbar area, including the gluteus and the corresponding flank. Antimycotic treatment proved ineffective, and the child died 8 weeks after the accident. Other cases due to this fungus are reviewed...
- Gastrointestinal mucormycosis--an uncommon isolated mucormycosisM C Sharma
Department of Pathology, All India Institute of Medical Sciences, New Delhi
Indian J Gastroenterol 17:131-3. 1998Isolated mucormycosis of the gastrointestinal tract is uncommon, with only two case reports from India.
- Sequence of oral manifestations in rhino-maxillary mucormycosisBharati R Doni
Department of Oral Medicine and Radiology, Seema Dental College and Hospital, Rishikesh, Uttharakhand, India
Indian J Dent Res 22:331-5. 2011b>Mucormycosis, caused by saprophytic fungi of the order Mucorales of the class Zygomycetes, is a rare opportunistic fungal infection, which has a rapidly progressive and fulminant course with fatal outcome...
- Fatal Apophysomyces elegans infection transmitted by deceased donor renal allograftsB D Alexander
Department of Medicine, Duke University Medical Center, Durham, NC, USA
Am J Transplant 10:2161-7. 2010Two patients developed renal mucormycosis following transplantation of kidneys from the same donor, a near-drowning victim in a motor vehicle crash...
- A massive intraventricular thrombosis by disseminated mucormycosis in a patient with myelodysplastic syndrome during deferoxamine therapyNaoshi Kubota
First Department of Internal Medicine, Second Department of Pathology, Tokyo Medical University
Haematologica 88:EIM13. 2003
- Neonatal lingual and gastrointestinal mucormycosis in a case of low anorectal malformation-a rare presentationRahul Gupta
Department of Pediatric Surgery, King Edward Memorial Hospital, Mumbai, India
J Pediatr Surg 46:745-8. 2011..Histopathology of the tissue specimen was suggestive of mucormycosis. Postoperatively, he received intravenous amphotericin B (liposomal) and was started on liquid enteral ..
- Palate ulcer due to mucormycosisDionysios E Kyrmizakis
Department of Otolaryngology, University of Crete, Greece
J Laryngol Otol 116:146-7. 2002b>Mucormycosis is caused by fungi of the order Mucorales and is one of the most rapidly fatal fungal infections known to man. Rhinocerebral mucormycosis is the most common type and its extension to the orbit and brain is quite usual...
- Successful treatment of massive lower gastrointestinal bleeding caused by mixed infection of cytomegalovirus and mucormycosis in a renal transplant recipientJ H Ju
Department of Internal Medicine, Kangnam St. Mary's Hospital, Catholic University of Korea, Seoul, Korea
Am J Nephrol 21:232-6. 2001We describe a case of lower gastrointestinal bleeding due to mixed infection of cytomegalovirus (CMV) and mucormycosis in a renal transplant recipient...
- Case report of hepatic mucormycosis after liver transplantation: successful treatment with liposomal amphotericin B followed by posaconazole sequential therapyC S Abboud
Serviço de Controle de Infecção Hospitalar e Seção Médica de Infectologia, Institute Dante Pazzanese de Cardiologia, Sao Paulo, Brazil
Transplant Proc 44:2501-2. 2012b>Mucormycosis is a rare but emerging fungal infection complicating solid organ transplantation (SOT), with a cumulative incidence of around 2% during the first year after SOT...
- Posaconazole for the treatment of mucormycosisD A Enoch
Clinical Microbiology and Public Health Laboratory, Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough City Hospital, Bretton Gate, Peterborough PE3 9GW, UK
Int J Antimicrob Agents 38:465-73. 2011..there is no strong published clinical evidence to support its role as a single agent in the treatment of mucormycosis. Further studies are required to explore its role as a single agent and in combination therapy for the ..
- Disseminated mucormycosis in an acquired immunodeficiency syndrome (AIDS) patientTeruhisa Fujii
Division of Blood Transfusion Services, Hiroshima University Hospital
Intern Med 42:129-30. 2003
- Isolated renal allograft arterial mucormycosis: an extremely rare complicationMukut Minz
Nephrol Dial Transplant 18:1034-5. 2003
- Apophysomyces elegans: epidemiology, amplified fragment length polymorphism typing, and in vitro antifungal susceptibility patternA Chakrabarti
Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
J Clin Microbiol 48:4580-5. 2010..Posaconazole is the most active drug against the isolates, followed by itraconazole. The MICs of amphotericin B against A. elegans were higher than those of the other drugs...
- Isolated bilateral renal mucormycosisS K Singh
Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Urology 63:979-80. 2004
- Mucormycosis: a rare but serious infectionDonna M Eichna
Inova Fairfax Hospital, Virginia, USA
Clin J Oncol Nurs 12:108-12. 2008..b>Mucormycosis, also known as zygomycosis, is an opportunistic fungal infection that is seen rarely in the clinical setting ..
- [Rhinocerebral mucormycosis: report on eight cases]Raquel Artal
Hospital Clinico Universitario Lozano Blesa, Zaragoza, Espana
Acta Otorrinolaringol Esp 61:301-5. 2010b>Mucormycosis is a serious condition, usually acute and often fatal, It presents in its most aggressive form in debilitated hosts, usually with diabetic ketoacidosis or immunosuppression...
- Rhinocerebral mucormycosis complicated by internal carotid artery thrombosis in a pediatric patient with type 1 diabetes mellitus: a case report and review of the literatureJill H Simmons
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
Pediatr Diabetes 6:234-8. 2005To illustrate that rapid diagnosis and aggressive treatment of rhinocerebral mucormycosis with internal carotid artery occlusion in a pediatric patient can prevent mortality and significant morbidity.
- Combined mucormycosis and candidiasis of the cecum presenting as a right iliac fossa mass in a patient with chronic kidney diseaseWaqas Wahid Baig
Department of Nephrology, Kasturba Medical College, Manipal 576104, Karnataka, India
Travel Med Infect Dis 6:145-7. 2008..To our knowledge, only one case of mucormycosis in an adult, presenting as a mass (appendiceal mass), has been reported [Ter Borg F, Kuijper EJ, van der Lelie ..
- External Iliac artery stent mucormycosis in a renal transplant patientChristos D Liapis
Department of Vascular Surgery, Athens University Medical School, Athens, Greece
Ann Vasc Surg 20:253-7. 2006..Histological examination of the thrombus revealed hyphae characteristic of mucormycosis. A combination of surgical and medical treatment with intravenous liposomal amphotericin B was applied, which ..
- Activated Targeted Killer (ATAK) Cells for Invasive Fungal InfectionsBrad J Spellberg; Fiscal Year: 2013..4) define the breadth of protection of ATAK cells against three highly lethal mold infections: aspergillosis, mucormycosis, or fusariosis...
- Iron Uptake and Mucormycosis PathogenesisAshraf S Ibrahim; Fiscal Year: 2013DESCRIPTION (provided by applicant): Mucormycosis, most commonly caused by Rhizopus oryzae, is a life-threatening infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), neutropenia, corticosteroid use, and/or ..
- Amphotericin B AnalogsCharles Hutchinson; Fiscal Year: 2009..Amphotericin B (AMB) continues to be an important drug for invasive aspergillosis, candidemia, mucormycosis, fusariosis and Cryptococcosis meningitis because of its potency, broad spectrum of activity and the low ..
- Iron Uptake and Mucormycosis PathogenesisAshraf Ibrahim; Fiscal Year: 2005applicant): Mucormycosis is a life-threatening infection that occurs in patients who are immunocompromised due to diabetic ketoacidosis, neutropenia, organ transplantation, and/or increased available serum iron...
- Treatment of Fungal Infections with ATAK CellsAshraf Ibrahim; Fiscal Year: 2004..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
- Novel Antifungal Strategies for Lethal MucormycosisAshraf Ibrahim; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Mucormycosis is a life-threatening infection that occurs in patients immunocompromised by diabetic ketoacidosis, neutropenia, corticosteroids, or organ transplantation...
- Adrenergic Antagonism During Murine CandidiasisBrad Spellberg; Fiscal Year: 2008..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
- Innate Effectors of rAls3p-N Anti-Candida VaccineBrad J Spellberg; Fiscal Year: 2010..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
- GPCR signaling cascades in Cryptococcus neoformansJoseph Heitman; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- C. Neoformans Infection in Organ Transplant RecipientsNina Singh; Fiscal Year: 2005..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
- Role of Calcineurin in Fungal VirulenceJoseph Heitman; Fiscal Year: 2009..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
- Genetics of mating and fruiting in Cryptococcus neoformansJoseph Heitman; Fiscal Year: 2010..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
- Genetic analysis of Cryptococcus neoformans virulenceJoseph Heitman; Fiscal Year: 2009..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
- Impact of ileal content on S typhimurium pathogenesisSara Lawhon; Fiscal Year: 2006..The research collaboration between Dr. B[unreadable]umler in the Texas A&M Health Science Center and Dr. Adams in the College of Veterinary Medicine provides a unique opportunity to achieve this career goal. ..
- Prevention/diagnosis/fungal infections/transplantationBarbara Alexander; Fiscal Year: 2005..This approach will shorten the time from development to clinical implementation in therapeutic trials and guidelines. ..
- Calcineurin and Aspergillus fumigatus PathogenesisWILLIAM STEINBACH; Fiscal Year: 2008..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..