endotoxemia

Summary

Summary: A condition characterized by the presence of endotoxins in the blood. If endotoxemia is the result of gram-negative rod-shaped bacteria, shock may occur.

Top Publications

  1. ncbi Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
  2. ncbi Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
  3. ncbi A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation
    Clett Erridge
    Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, United Kingdom
    Am J Clin Nutr 86:1286-92. 2007
  4. ncbi Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Av E Mounier, 73 69, 1200 Brussels, Belgium
    Diabetologia 50:2374-83. 2007
  5. ncbi Inflammation impairs reverse cholesterol transport in vivo
    Fiona C McGillicuddy
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 119:1135-45. 2009
  6. ncbi Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines
    Sumana Chakravarty
    Section on Functional Neuroanatomy, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 25:1788-96. 2005
  7. pmc Protein kinase C δ (PKCδ)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia
    Kyung Tae Noh
    Department of Microbiology and Immunology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam do 626 870, South Korea
    J Biol Chem 287:14226-33. 2012
  8. pmc Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation
    Subhabrata Basu
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio, USA
    Obesity (Silver Spring) 19:476-82. 2011
  9. ncbi Energy intake is associated with endotoxemia in apparently healthy men
    Jacques Amar
    INSERM 558, Toulouse, France
    Am J Clin Nutr 87:1219-23. 2008
  10. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006

Detail Information

Publications361 found, 100 shown here

  1. ncbi Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
    ..We found that normal endotoxemia increased or decreased during the fed or fasted state, respectively, on a nutritional basis and that a 4-week ..
  2. ncbi Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
    ..We previously determined, first, that metabolic endotoxemia controls the inflammatory tone, body weight gain, and diabetes, and second, that high-fat feeding modulates gut ..
  3. ncbi A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation
    Clett Erridge
    Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, United Kingdom
    Am J Clin Nutr 86:1286-92. 2007
    ..Endotoxin circulates at low concentrations in the blood of all healthy individuals, although elevated concentrations are associated with an increased risk of atherosclerosis...
  4. ncbi Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Av E Mounier, 73 69, 1200 Brussels, Belgium
    Diabetologia 50:2374-83. 2007
    ..caecal content in mice. We therefore tested whether restoration of the quantity of caecal Bifidobacterium spp. could modulate metabolic endotoxaemia, the inflammatory tone and the development of diabetes...
  5. ncbi Inflammation impairs reverse cholesterol transport in vivo
    Fiona C McGillicuddy
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 119:1135-45. 2009
    ..The present study presents the first integrated functional evidence that inflammation retards numerous components of RCT...
  6. ncbi Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines
    Sumana Chakravarty
    Section on Functional Neuroanatomy, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 25:1788-96. 2005
    ..Our findings demonstrate a requirement for TLR4 function in CNS-resident cells, independent of systemic cytokine effects, for sustained CNS-specific inflammation and corticosterone rise during endotoxemia.
  7. pmc Protein kinase C δ (PKCδ)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia
    Kyung Tae Noh
    Department of Microbiology and Immunology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam do 626 870, South Korea
    J Biol Chem 287:14226-33. 2012
    ..by the inhibition of GSK-3 provoked the production of interleukin (IL)-10, playing a crucial role in regulating endotoxemia. Using a mitogen-activated protein kinase kinase-1 (MEK-1) and PKCδ inhibitor, we confirmed that GSK-3 ..
  8. pmc Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation
    Subhabrata Basu
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio, USA
    Obesity (Silver Spring) 19:476-82. 2011
    ..to characterize the immune responses developed by the adipose tissue (AT) and their potential links to maternal endotoxemia in pregnancy with obesity...
  9. ncbi Energy intake is associated with endotoxemia in apparently healthy men
    Jacques Amar
    INSERM 558, Toulouse, France
    Am J Clin Nutr 87:1219-23. 2008
    ..The bridge between food intake and weight is not fully understood. Recently, the role of gut microbiota and bacterial lipopolysacharides (LPS) in weight has been noted...
  10. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ..stimulation fails to inhibit tumor necrosis factor (TNF) production in splenectomized animals during lethal endotoxemia. Selective lesioning of the common celiac nerve abolishes TNF suppression by vagus nerve stimulation, ..
  11. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia)...
  12. ncbi Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki, Haartmaninkatu 8, PO Box 63, FI 00014 Helsinki, Finland
    Arterioscler Thromb Vasc Biol 27:1433-9. 2007
    In periodontitis, overgrowth of gram-negative bacteria may cause endotoxemia and systemic inflammation leading to cardiovascular diseases (CVD)...
  13. pmc A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes Care 33:1925-32. 2010
    Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis of obesity and metabolic risk...
  14. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
    ..This study sought to explore potential mechanisms of inflammatory-induced IR in humans with a focus on adipose tissue...
  15. pmc Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
    ..Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin is the necessary ..
  16. ncbi Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation
    Fabienne Laugerette
    INRA UMR1235, RMND, Villeurbanne, F 69621 France
    J Nutr Biochem 22:53-9. 2011
    ..study, we first investigated in humans the impact of a mixed meal containing dispersed lipids on postprandial endotoxemia and inflammation...
  17. ncbi Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia
    Janesh Pillay
    Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    J Leukoc Biol 88:211-20. 2010
    ....
  18. pmc SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance
    Lei Cai
    Department of Internal Medicine, Cardiovascular Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Clin Invest 118:364-75. 2008
    ..We conclude that SR-BI in mice is required for the antiinflammatory response to LPS-induced endotoxic shock, likely through its essential role in facilitating glucocorticoid production and LPS hepatic clearance...
  19. ncbi Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  20. pmc Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
    Mauricio Rosas-Ballina
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 105:11008-13. 2008
    ..Here, we show that vagus nerve stimulation during endotoxemia specifically attenuates TNF production by spleen macrophages in the red pulp and the marginal zone...
  21. ncbi Sevelamer decreases systemic inflammation in parallel to a reduction in endotoxemia
    A E M Stinghen
    Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
    Blood Purif 29:352-6. 2010
    ..In the present study, we investigated the impact of sevelamer hydrochloride treatment in reducing endotoxemia and inflammation in a group of hemodialysis (HD) patients.
  22. ncbi Effect of short-term intralipid infusion on the immune response during low-dose endotoxemia in humans
    Rikke Krogh-Madsen
    Rigshospitalet, Section 7641, Blegdamsvej 9, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 294:E371-9. 2008
    ..Short-term hyperlipidemia enhances the inflammatory response to endotoxin, and skeletal muscle and adipose tissue are capable of producing essential inflammatory mediators after endotoxin stimulation...
  23. ncbi Endotoxemia impairs heart mitochondrial function by decreasing electron transfer, ATP synthesis and ATP content without affecting membrane potential
    Virginia Vanasco
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    J Bioenerg Biomembr 44:243-52. 2012
    Acute endotoxemia (LPS, 10 mg/kg ip, Sprague Dawley rats, 45 days old, 180 g) decreased the O₂ consumption of rat heart (1 mm³ tissue cubes) by 33% (from 4.69 to 3.11 μmol O₂/min. g tissue)...
  24. pmc Of microbes and meals: the health consequences of dietary endotoxemia
    Caleb J Kelly
    Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Nutr Clin Pract 27:215-25. 2012
    ..In this review, the authors present an overview of the biochemical and cellular mechanisms that lead to endotoxemia, with emphasis on the interplay between microbial and nutrition determinants of this condition...
  25. pmc Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia
    Stan de Kleijn
    Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e38255. 2012
    ..Previous studies have investigated gene transcription during experimental endotoxemia in whole blood and peripheral blood mononuclear cells...
  26. pmc A high-fat diet is associated with endotoxemia that originates from the gut
    Swaroop Pendyala
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10065, USA
    Gastroenterology 142:1100-1101.e2. 2012
    b>Endotoxemia, characterized by an excess of circulating bacterial wall lipopolysaccharide, is associated with systemic inflammation and the metabolic syndrome...
  27. ncbi Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia
    Wim van der Meer
    Department of Clinical Chemistry, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Endotoxin Res 13:94-100. 2007
    ..of neutrophil membrane CD64 expression were examined during a standardized inflammatory response, using a human endotoxemia model, and compared with hematological indices, CRP, cytokines and interleukins...
  28. pmc Disassociation of muscle insulin signaling and insulin-stimulated glucose uptake during endotoxemia
    Kimberly X Mulligan
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine Nashville, Tennessee, United States of America
    PLoS ONE 7:e30160. 2012
    ..Thus, in vivo acute endotoxemia does not impair insulin signaling through the PI3-kinase pathway in skeletal muscle and decreased tissue blood ..
  29. ncbi Effects of low dose endotoxemia on endothelial progenitor cells in humans
    F B Mayr
    Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Atherosclerosis 195:e202-6. 2007
    ..Levels of circulating EPCs have been investigated in different inflammatory disease states. However, data on circulating EPC levels and systemic inflammation remain scarce and contradictory...
  30. ncbi Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans
    Sven Benson
    Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Pain 153:794-9. 2012
    ..Our results support the relevance of inflammatory processes in the pathophysiology of visceral hyperalgesia and underscore the need for studies to further elucidate immune-to-brain communication pathways in gastrointestinal disorders...
  31. ncbi VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNgamma synthesis by T cells
    M Delgado
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102 1811, USA
    J Neuroimmunol 96:167-81. 1999
    ..The presence of VIP/PACAP in the lymphoid organs and the specific effects on cytokine production offer a physiological basis for their immunomodulatory role in vivo...
  32. ncbi A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse
    Takayuki Iwaki
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Blood 105:2364-71. 2005
    ....
  33. ncbi Systemic endotoxemia during chronic viral hepatitis
    A S Sozinov
    Kazan State Medical University
    Bull Exp Biol Med 133:153-5. 2002
    Incidence and severity of systemic endotoxemia in patients with chronic viral hepatitis B and C were studied using the limulus test. Healthy subjects and patients with acute viral hepatitis B and C comprised reference groups...
  34. pmc Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia
    Manjula Karpurapu
    Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Illinois, Chicago, 60612, USA
    Blood 118:5255-66. 2011
    ..1-deficient mice, establishing a novel protective mechanistic role for the lineage-specific transcription factor PU.1...
  35. ncbi Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation
    D I Campbell
    Medical Research Council, Keneba, The Gambia
    J Nutr 133:1332-8. 2003
    ..These data are consistent with the hypothesis of translocation of immunogenic lumenal macromolecules across a compromised gut mucosa, leading to stimulation of systemic immune/inflammatory processes and subsequent growth impairment...
  36. ncbi Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress
    H Jaeschke
    Department of Pharmacology, Pharmacia and Upjohn, Inc, Kalamazoo, MI, USA
    Hepatology 29:443-50. 1999
    ..Thus, strengthening defense mechanisms against ROS in target cells can attenuate excessive inflammatory injury without affecting host defense reactions...
  37. pmc Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia
    Philipp Wiesner
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0682, USA
    Circ Res 107:56-65. 2010
    ..In addition, low-level but persistent metabolic endotoxemia is often found in diabetic and obese subjects and is induced in mice fed a high-fat diet.
  38. pmc Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals
    Anne Roslev Bukh
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    PLoS ONE 6:e21275. 2011
    ..Microbial translocation may contribute to the immunopathogenesis in HIV infection. We investigated if microbial translocation and inflammation were associated with innate and adaptive immune responses in adults with HIV...
  39. pmc Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cells
    Daniel Onguru
    Vector Biology and Control Research Centre, Kenya Medical Research Institute, Kisian, Kenya
    Am J Trop Med Hyg 84:321-4. 2011
    ..We show that schistosomiasis is associated with extremely high levels of endotoxemia as well as high mobility group 1, an endogenous inflammatory TLR ligand, in the absence of other coinfected ..
  40. pmc Circulating endotoxemia: a novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease
    Christopher W McIntyre
    Department of Renal Medicine, Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3NE, United Kingdom
    Clin J Am Soc Nephrol 6:133-41. 2011
    ..This study's aim was to investigate endotoxemia across the spectrum of chronic kidney disease (CKD).
  41. pmc Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 103:5219-23. 2006
    ..inhibits the production of TNF and other cytokines and protects animals from the inflammatory damage caused by endotoxemia and severe sepsis...
  42. ncbi TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis
    A A Dias
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    J Leukoc Biol 69:928-36. 2001
    ..The data shown here are the first in vivo evidence of the involvement of TSG-14 in the inflammatory process and suggest a role for TSG-14 in the defense against bacterial infections...
  43. ncbi Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease
    R K Rao
    Department of Physiology, University of Tennessee, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 286:G881-4. 2004
    A significant body of evidence indicates that endotoxemia and endotoxin-mediated hepatocellular damage play a crucial role in the pathogenesis of alcoholic liver disease...
  44. ncbi In vivo profile of the human leukocyte microRNA response to endotoxemia
    Wolfgang M Schmidt
    Department of Clinical Pharmacology, Division of Pharmacogenetics and Imaging, Medical University of Vienna, A 1090 Vienna, Austria
    Biochem Biophys Res Commun 380:437-41. 2009
    ..associated with the pronounced down-regulation of the B-cell CLL/lymphoma 2 (BCL2) gene expression during LPS endotoxemia, and could further be involved in the translational silencing of several other predicted inflammation-related ..
  45. pmc The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
    Chunzhang Cao
    Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 120:1971-80. 2010
    ..Using an LPS-induced mouse model of lethal endotoxemia, we showed that APC administration reduced the mortality of wild-type mice, but not CD11b-deficient mice...
  46. pmc Endotoxemia is associated with an increased risk of incident diabetes
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Diabetes Care 34:392-7. 2011
    ..Diabetes is accompanied with a chronic low-grade inflammation, which may in part be mediated by endotoxins derived from Gram-negative bacteria...
  47. ncbi Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
    Marina C Pils
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 40:443-8. 2010
    ..We show that, in an IL-10-dependent LPS model of endotoxemia, dampening of the immune response requires expression of IL-10R1 in monocytes/macrophages and/or neutrophils ..
  48. ncbi Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study
    C J Wiedermann
    Department of Internal Medicine, Medical Faculty, University of Innsbruck, Austria
    J Am Coll Cardiol 34:1975-81. 1999
    ..Focus of the current study was on the significance of bacterial endotoxin, which shows a variety of pro-atherogenic properties and may occur at high concentration in the circulation of infected subjects...
  49. ncbi Innate immunity modulates adipokines in humans
    Paul D Anderson
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Endocrinol Metab 92:2272-9. 2007
    ..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...
  50. pmc Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks endotoxemia
    Santosh K Panda
    Institute of Life Sciences, Bhubaneswar, India
    PLoS Pathog 8:e1002717. 2012
    ..and in the process inhibits LPS mediated classical activation which leads to inflammation associated with endotoxemia. The active component of the nematode glycoprotein mediating alternate activation of macrophages was found to ..
  51. ncbi Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia
    Ai Wen Feng
    School of Medicine, Nanjing University, Nanjing, Jiangsu 210093, China
    Fitoterapia 82:976-82. 2011
    ..COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR ..
  52. ncbi Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis
    R C Reddy
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0360, USA
    Am J Physiol Lung Cell Mol Physiol 281:L537-43. 2001
    ..were performed to evaluate the effect of cyclooxygenase (COX)-2-specific inhibition on the outcome in murine endotoxemia and cecal ligation and puncture (CLP)...
  53. ncbi Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia
    P E Wischmeyer
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Shock 16:398-402. 2001
    ..b>Endotoxemia was induced in Male Sprague-Dawley rats by intravenous administration of 5 mg/kg Escherichia coli ..
  54. ncbi Endotoxemia and acute-phase proteins in major abdominal surgery
    K Buttenschoen
    Department of General Surgery, University of Ulm, Steinhoevelstrasse 9, D 89075, Ulm, Germany
    Am J Surg 181:36-43. 2001
    Translocation of endotoxin is a controversial issue. The ability of plasma to inactivate endotoxin is an indirect measure of endotoxemia. Endotoxin is a potent stimulator of the inflammatory response and affects the innate immune system.
  55. ncbi Endotoxemia and endotoxin tolerance in patients with ARDS
    Klaus Buttenschoen
    Department of General Surgery, University of Ulm, Ulm, Germany
    Langenbecks Arch Surg 393:473-8. 2008
    The significance of endotoxemia in man is controversial, induces cytokine release and stimulates the immune system...
  56. pmc Inflammation induces fibrinogen nitration in experimental human endotoxemia
    Sean P Heffron
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Free Radic Biol Med 47:1140-6. 2009
    ..We used a recently validated ELISA to quantify nitrated fibrinogen during experimental human endotoxemia (N=23) and in a cohort of healthy adults (N=361) who were characterized for inflammatory and HDL parameters as ..
  57. ncbi Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney
    Patrick N Cunningham
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 168:5817-23. 2002
    ..Therefore, TNF is a key mediator of LPS-induced ARF, acting through its receptor TNFR1 in the kidney...
  58. ncbi Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death
    Kuniaki Ejima
    Brigham and Women s Hospital, Pulmonary and Critical Care Medicine, 75 Francis St, Boston, MA 02115, USA
    FASEB J 17:1325-7. 2003
    ..The present study investigates the role of cyclooxygenase (COX)-2 in host responses to bacterial endotoxemia. After administration of Escherichia coli lipopolysaccharide, 50% of wild-type mice die within 96 h...
  59. ncbi An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia
    N Laflamme
    Laboratory of Molecular Endocrinology, Centre de Recherche de l Université Laval Research Center, Department of Anatomy, Laval University, Quebec, Canada G1V 4G2
    J Neurosci 19:10923-30. 1999
    ..indicate that IL-1beta has an obligatory role in the activation of NF-kappaB molecules and PGs within endothelial cells of the BBB in an experimental model of intramuscularly turpentine-induced inflammation but not during endotoxemia.
  60. pmc Serum heparan sulfate levels are elevated in endotoxemia
    Klaus F Hofmann-Kiefer
    Clinic of Anesthesiology Critical Care Medicine and Pain Therapy M A B, P C, Ludwig Maximilians University, City of Munich, Germany
    Eur J Med Res 14:526-31. 2009
    ..g. the vascular barrier and inflammation. Heparan sulfate, one of its essential components is characteristically traceable in blood, in case the endothelial glycocalyx is damaged or destroyed...
  61. pmc Tetrahydro iso-alpha acids from hops improve glucose homeostasis and reduce body weight gain and metabolic endotoxemia in high-fat diet-fed mice
    Amandine Everard
    Universite Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
    PLoS ONE 7:e33858. 2012
    ..e. metabolic endotoxemia. Various phytochemical compounds have been investigated as potential tools to regulate these metabolic features...
  62. ncbi A dual negative regulation model of Toll-like receptor 4 signaling for endotoxin preconditioning in human endotoxemia
    Qian Yang
    Chemical Engineering, Rutgers University, Piscataway, NJ 08854, USA
    Math Biosci 232:151-63. 2011
    ..Finally, the pretreatment with PI3K inhibitor reveals the interaction between these two negative regulations...
  63. ncbi Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels
    E Otero-Anton
    Department of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
    Eur Surg Res 33:77-9. 2001
    ..Cecal ligation and puncture is a widely used experimental model of sepsis...
  64. ncbi Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats
    Chih Lin Yang
    Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    J Surg Res 167:e273-81. 2011
    ..is crucial in mediating the development of ventilator-induced lung injury (VILI) in animals experiencing endotoxemia. Dexmedetomidine and ketamine are two sedative agents with potent anti-inflammatory capacity...
  65. ncbi Release of urokinase plasminogen activator receptor during urosepsis and endotoxemia
    S Florquin
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Kidney Int 59:2054-61. 2001
    ..The urokinase receptor (uPAR; CD87) is a multifunctional molecule involved in fibrinolysis, in proteolysis, in renal tubular functions, and in migration and adhesion of inflammatory cells to the site of infection...
  66. ncbi Reduced caloric intake during endotoxemia reduces arginine availability and metabolism
    Martijn Poeze
    Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Clin Nutr 91:992-1001. 2010
    ..Availability of arginine may further decrease during reduced caloric intake, which thereby limits the adaptive response of arginine-nitric oxide metabolism during sepsis...
  67. ncbi Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13
    T van der Poll
    Cornell University Medical College, Department of Surgery, New York, New York 10021, USA
    J Infect Dis 175:118-22. 1997
    ..IL-13 remained undetectable in the vast majority of patients and was not induced by endotoxin. Enhanced IL-13 production does not seem to be part of an inducible host defense mechanism during sepsis...
  68. ncbi Local expression of tumor necrosis factor-alpha and interleukin-10 on wound healing of intestinal anastomosis during endotoxemia in mice
    Ken Ishimura
    First Department of Surgery, Kagawa Medical University, 1750 1, Ikenobe, Miki, Kita, Kagawa, 761 0793, Japan
    J Surg Res 108:91-7. 2002
    ....
  69. ncbi Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia
    Bengt Age Sørby Borge
    Dept of Biomedicine, Univ of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Am J Physiol Heart Circ Physiol 296:H735-44. 2009
    ..The role of skeletal muscle myocytes as a source for cytokines during endotoxemia was explored by collecting muscle ISF using a wick method, and the levels of 14 cytokines in ISF and plasma ..
  70. ncbi The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid
    Virginia Vanasco
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Free Radic Res 42:815-23. 2008
    ..to study the mitochondrial function and to evaluate (a) the oxidative stress in real time in an acute model of endotoxemia and (b) the effect of alpha-lipoic acid (LA, 100 mg/kg) as a therapeutic strategy to be considered...
  71. ncbi Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2
    Julie Audoy-Rémus
    Department of Oncology and Molecular Endocrinology, Laval University Hospital Research Center, Quebec City, Quebec, Canada
    J Neurosci 28:10187-99. 2008
    ..provide evidence that CD68(+)GR1(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endothelium, these monocytes start to crawl, adopt a rod-shaped morphology when passing ..
  72. ncbi Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance
    J M Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona IdIBGi and University Hospital Dr Josep Trueta, CIBER Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Catalonia, Spain
    Int J Obes (Lond) 34:240-9. 2010
    ..We hypothesized that endotoxin (lipopolysaccharide, LPS) and fat intake were in the background of these associations...
  73. ncbi The sympathetic-vagal balance against endotoxemia
    Jian Huang
    Intensive Care Unit, Trauma Center of PLA, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    J Neural Transm 117:729-35. 2010
    ..We established an endotoxemia model in Sprague-Dawley rats using lipopolysaccharide (LPS) injection...
  74. ncbi Microcirculatory endothelial dysfunction during endotoxemia--insights into pathophysiology, pathologic mechanisms and clinical relevance
    Marcus Czabanka
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Curr Vasc Pharmacol 5:266-75. 2007
    ..This review considers endothelial cell dysfunction during endotoxemia including current insights into sepsis pathophysiology...
  75. pmc The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia
    Xianxi Wang
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Ohio, USA
    Life Sci 83:671-80. 2008
    ..The specific aim of the present study is to understand the role of Mkp-1 in the anti-inflammatory function of glucocorticoids...
  76. ncbi NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia
    Jaspreet S Gujral
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Physiol Gastrointest Liver Physiol 287:G243-52. 2004
    Neutrophils can cause liver injury during endotoxemia through generation of reactive oxygen species. However, the enzymatic source of the oxidant stress and the nature of the oxidants generated remain unclear...
  77. pmc Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway
    Hidefumi Komura
    Department of Surgery, North Shore University Hospital and The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 182:581-7. 2009
    ..In addition, endotoxemia was elicited by i.p. injection of LPS...
  78. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
  79. pmc Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response
    Elena Gonzalez-Rey
    Instituto de Parasitologia y Biomedicina, Consejo Superior de Investigaciones Cientificas, Avd Conocimiento, Parque Tecnologico Ciencias de la Salud, Granada 18100, Spain
    Am J Pathol 168:1921-30. 2006
    ..Importantly, UCN or AM treatment was therapeutically effective in established endotoxemia. In conclusion, UCN and AM could represent two multistep therapeutic agents for human septic shock to be used ..
  80. ncbi Low-grade endotoxemia in patients with severe autism
    Enzo Emanuele
    Department of Health Sciences, Section of Psychiatry, University of Pavia, via Bassi, 21, I 27100, Pavia, Italy
    Neurosci Lett 471:162-5. 2010
    ..Whether increased endotoxin may contribute to the pathophysiology of inflammation and impaired reciprocal social interaction in autism should be further explored in future studies...
  81. ncbi Attenuation of acute lung injury with propofol in endotoxemia
    Yumiko Takao
    Department of Anesthesia and Perioperative Medicine, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kusunoki cho 7, Chuo Ku, Kobe 650 0017, Japan
    Anesth Analg 100:810-6, table of contents. 2005
    ..We conducted this study to evaluate whether propofol attenuates ALI associated with endotoxemia. Thirty-two anesthetized rabbits were randomly divided into four groups (n = 8 each)...
  82. pmc Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice
    Edward Kerschen
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Clin Invest 120:3167-78. 2010
    Activated protein C (aPC) therapy reduces mortality in adult patients with severe sepsis. In mouse endotoxemia and sepsis models, mortality reduction requires the cell signaling function of aPC, mediated through protease-activated ..
  83. ncbi Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 35:1139-44. 2007
    ..Here we studied whether GTS-21, a selective alpha7-nicotinic acetylcholine receptor agonist, inhibits proinflammatory cytokines in vitro and in vivo and improves survival in murine endotoxemia and severe sepsis.
  84. ncbi Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus
    Scott V Monte
    State University of New York at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Amherst, NY, USA
    Surgery 151:587-93. 2012
    ..Because RYGB may diminish LPS from endogenous and exogenous sources, we hypothesized that LPS and the associated cascade of oxidative and inflammatory stress would diminish after RYGB...
  85. pmc Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia
    Mohamed Lamkanfi
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    J Immunol 185:4385-92. 2010
    ..This finding indicates the existence of another caspase 1-dependent mediator of endotoxemia. Reduced serum high mobility group box 1 (HMGB1) levels in caspase 1-deficient mice correlated with their ..
  86. ncbi Proinflammatory effects of IL-10 during human endotoxemia
    F N Lauw
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:2783-9. 2000
    ..These data indicate that high-dose IL-10 treatment in patients with inflammatory disorders can be associated with undesired proinflammatory effects...
  87. ncbi Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia
    Anne Sofie Andreasen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, University Hospital Rigshospitalet, Rigshospitalet M 7641, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Intensive Care Med 36:1548-55. 2010
    ..This may partly be due to immune dysfunction. We investigated the in vivo innate immune response of type 2 diabetic persons to an intravenous injection of E. coli lipopolysaccharide (LPS)...
  88. pmc Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    Ece Mutlu
    Rush University Medical Center, Division of Digestive Diseases and Nutrition, Nutrition Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 33:1836-46. 2009
    ..Although gut leakiness is clearly an important cause of endotoxemia in ALD, it cannot fully explain endotoxemia in all ALD subjects and thus other factors may be involved...
  89. ncbi Human endotoxemia: a model for mechanistic insight and therapeutic targeting
    Stephen F Lowry
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Shock 24:94-100. 2005
    ..By contrast, the model cannot predict clinical efficacy among higher risk patients nor in those who have endured extended periods of inflammatory stress...
  90. pmc The influence of corticosteroids on the release of novel biomarkers in human endotoxemia
    Martijn D de Kruif
    Center for Experimental and Molecular Medicine, Room G2 132, Academic Medical Center, Meibergdreef 9, 1105 Amsterdam, AZ, The Netherlands
    Intensive Care Med 34:518-22. 2008
    ..However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone.
  91. ncbi GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat
    Laura Dugo
    Centre for Experimental Medicine, Nephrology and Critical Care Medicine, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, UK
    Crit Care Med 33:1903-12. 2005
    ..Here we investigate the effects of GSK-3beta inhibition on organ injury/dysfunction caused by lipopolysaccharide or coadministration of lipopolysaccharide and peptidoglycan in the rat...
  92. ncbi Cerebellar white matter injury following systemic endotoxemia in preterm fetal sheep
    J M Dean
    Department of Physiology and Neuroscience, Perinatal Centre, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Neuroscience 160:606-15. 2009
    ....
  93. pmc Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
    Yongseok Choi
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Exp Mol Med 40:574-81. 2008
    ..It also inhibited TNF-alpha production in vivo as demonstrated in a LPS-induced mouse endotoxemia model...
  94. ncbi Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model
    Cornelis van 't Veer
    Center for Infection and Immunity Amsterdam, The Netherland
    J Immunol 179:7110-20. 2007
    ..In this study, we describe the expression kinetics of these LPS tolerance factors in standardized human endotoxemia models using i.v. LPS bolus administration...
  95. ncbi Human endotoxemia as a model of systemic inflammation
    A S Andreasen
    Centre of Inflammation and Metabolism, University of Copenhagen, Rigshospitalet 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Curr Med Chem 15:1697-705. 2008
    ..Finally, we outline the ethical considerations that apply to the use of human endotoxin model...
  96. ncbi Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice
    V E Laubach
    Department of Surgery, University of Virginia, Health Sciences Center, Charlottesville, Virginia 22908, USA
    Am J Physiol 275:H2211-8. 1998
    ..We hypothesized that NO is beneficial during endotoxemia and that this beneficial effect is influenced by sex hormones...
  97. ncbi Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004
    ..g., 10 ng/ml). Taken together, these data suggest that LPS stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms...
  98. pmc Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Exp Mol Pathol 83:177-87. 2007
    Acute endotoxemia is associated with production of acute phase proteins which regulate inflammatory responses to tissue injury...
  99. ncbi Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers
    Lucas T van Eijk
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 35:1464-9. 2007
    To determine gender differences in the innate immune response and vascular reactivity during human endotoxemia.
  100. pmc The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Nutr 136:360-5. 2006
    ..on endotoxin-induced HMGB1 release in vitro, and explored its therapeutic potential in animal models of lethal endotoxemia and sepsis [induced by cecal ligation and puncture (CLP)] in vivo...
  101. ncbi Role of ubiquitin-proteasome pathway in skeletal muscle wasting in rats with endotoxemia
    Jiake Chai
    Department of Burns and Plastic Surgery, Burns Institute, 304th Hospital, 100037 Beijing, China
    Crit Care Med 31:1802-7. 2003
    To investigate the mechanism of muscle protein breakdown under endotoxemia condition.

Research Grants70

  1. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..We will now test this agent in a series of investigations in order to determine the optimal dose, to confirm the mechanism of action, and to establish the window of opportunity after disease onset within which therapy may be initiated. ..
  2. Neuroprotection and Myelin Repair Mechanisms in Multiple Sclerosis
    Inderjit Singh; Fiscal Year: 2013
    ..activities of AMPK were also evident in lipopolysaccharide (LPS)-stimulated astrocytes in vitro as well as in endotoxemia model...
  3. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..The investigations will employ experimental models of endotoxemia and sepsis utilizing mouse strains that carry genetically silenced forms of these X-linked proteins...
  4. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ..It has been shown that portal endotoxemia, induced by oral administration of dextrans specifically causes biliary damage in Cftr-KO mice, but not in ..
  5. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..Ultimate Goal of the project is to develop a novel, specific therapy for sepsis/endotoxemia based on the ability of hepatic argininosuccinate synthase (ASS) to ameliorate injurious effects of bacterial ..
  6. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..L-97-1, as an adjunctive, anti-sepsis treatment in an animal model of polymicrobial sepsis, bacteremia, and endotoxemia (rat cecal ligation and puncture [CLP]). Administration of L-97-1 as a single intravenous (i.v...
  7. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2013
    ..and experimental studies indicates that elevated intestinal permeability to endotoxins and the resulting endotoxemia play a crucial role in the pathogenesis of alcoholic liver disease...
  8. TNF and Mitochondrial Dysfunction in ALD
    Craig J McClain; Fiscal Year: 2010
    ..We postulate that chronic alcohol abusecauses increased gut permeability and endotoxemia(increased LPS), depletionof critical antioxidants (e.g...
  9. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2013
    ..peptides antagonists attenuated SAA-induced HMGB1 release, and conferred protection in animal models of lethal endotoxemia and sepsis...
  10. Probiotics and HIF signaling in Alcoholic Liver Disease
    Wenke Feng; Fiscal Year: 2013
    ..that chronic alcohol feeding decreased intestinal HIF-2, ITF and tight junction expression leading to increased endotoxemia and ultimately liver injury...
  11. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2010
    Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
  12. NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSIS
    John W Christman; Fiscal Year: 2013
    ..NADPH oxidase-generated ROS signaling converts macrophages from a pro- to anti- inflammatory phenotype during endotoxemia. We will address the postulate that this phenotype switch occurs via NADPH oxidase-generated ROS activation of ..
  13. Dietary Fat in Ethanol-Induced Intestinal Barrier Dysfunction in ALD
    Irina Kirpich; Fiscal Year: 2013
    ..permeability resulting from the disruption of intestinal integrity is a major cause of alcohol-induced endotoxemia. Dietary fat is an important cofactor for the development of ALD...
  14. Mechanisms of Liver Failure
    Chandrashekhar R Gandhi; Fiscal Year: 2013
    ..of LPS on Kupffer cells, thus exemplifying the unique aspect of HSC-LPS interactions in hepatic pathobiology of endotoxemia. Therefore, we will test the hypothesis that IFN-2 and FasL derived from LPS- stimulated HSCs play a major role ..
  15. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    ..Increased levels of this protein have been shown to mediate lethality in mice models of acute inflammation (endotoxemia) and septic shock (cecal ligation and puncture)...
  16. Aldehydes in Alcohol-Induced Organ Injury
    Zhanxiang Zhou; Fiscal Year: 2013
    ..Alcohol consumption causes gut barrier disruption, leading to endotoxemia, which, in turn, causes tissue injury at the liver-brain axis by stimulating cytokine production...
  17. A new smart neonatal incubator for real-time detection of sepsis
    De Ann M Pillers; Fiscal Year: 2013
    ..e. 13C/12C ratio) as early as 2 hours after onset of induced endotoxemia and 14 to 18 hours earlier than clinical signs of septic shock...
  18. Endothelial Injury in Endotoxin-Induced Acute Renal Failure
    Patrick N Cunningham; Fiscal Year: 2013
    ..allow real-time measurement of intrarenal hemodynamics in response to the above manipulations in the setting of endotoxemia. Specific Aim 3 will test the hypothesis that TNF-induced caspase activation amplifies renal endothelial ..
  19. Cholinergic regulation of NF-kB in sepsis
    Luis Ulloa; Fiscal Year: 2012
    ..of the disease, also attenuate systemic inflammation and "rescue" mice from "established" sepsis both in lethal endotoxemia and cecal ligation and puncture...
  20. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2013
    ..EGCG) effectively attenuated endotoxin-induced HMGB1 release, and improved animal survival in murine models of endotoxemia and sepsis when given intraperitoneally...
  21. Nanog-positive cancer stem cells in and liver oncogenesis by alcohol and HCV
    Keigo Machida; Fiscal Year: 2013
    ..TLR4 signaling activated by alcohol-induced endotoxemia, induces the progenitor/stem marker Nanog and liver tumors in NS5A transgenic (Tg) mice but not in wild type (..
  22. Effect of Lactoferrin on Alcohol-Induced Dysbiosis and Gut Barrier Dysfunction
    Cynthia Ju; Fiscal Year: 2013
    ..Therefore, it is imperative to develop new therapeutic strategies. Alcohol-induced endotoxemia is a critical factor in causing ALD...
  23. Novel therapies in alcoholic hepatitis University of Louisville
    Craig J McClain; Fiscal Year: 2013
    ..Aim 1 will evaluate novel mechanisms for alcohol-induced alterations in gut integriy leading to endotoxemia and AH. We will study the therapeutic efficacy of both live probiotics and probiotic supernatants...
  24. Regulation of Age-Related Inflammation in Septic Shock
    Ping Wang; Fiscal Year: 2010
    ..We have shown that an increase in proinflammatory cytokines is greater in aged rats with endotoxemia, resulting in high lethality...
  25. Central cholinergic regulation of inflammation
    VALENTIN ATANASSOV PAVLOV; Fiscal Year: 2013
    ..brain cholinergic pathways in the central cholinergic regulation of the systemic inflammatory response during endotoxemia and polymicrobial sepsis...
  26. Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin
    Xiaojing Ma; Fiscal Year: 2011
    ..First, we will assess whether deletion of the pgrn gene affects survival of mice subjected to LPS-induced endotoxemia, and if administration of recombinant IL-10 or expression of an il10 transgene can ease the susceptibility of ..
  27. Mechanisms of Sensitization to TNF hepatotoxicity in ALD
    Zhenyuan Song; Fiscal Year: 2009
    ..We postulate that chronic alcohol abuse causes increased gut permeability and endotoxemia, generation of reactive oxygen intermediates, activation of Kupffer cell NFkB with increased TNF production, ..
  28. Mechanism of action and therapeutic potential of HMGB1 A box in sepsis
    Huan Yang; Fiscal Year: 2013
    ..Administration of A box rescues mice from lethal endotoxemia or sepsis caused by cecal ligation and puncture, a clinically relevant sepsis model...
  29. Hepatic Encephalopathy in Alcoholic Cirrhosis: A Systems Biology Approach
    Jasmohan S Bajaj; Fiscal Year: 2012
    ..alteration in their gut flora population and function that is linked with a pro- inflammatory milieu and endotoxemia and associated impaired brain function and hepatic encephalopathy, compared to those who do not have alcoholic ..
  30. Vesicular trafficking mechanisms regulating granulocyte function
    SERGIO DANIEL CATZ; Fiscal Year: 2013
    ..the host and neutrophil secretory proteins play a fundamental role in the damage to endothelium associated with endotoxemia and sepsis, these studies have important physiological significance and potential clinical applications in ..
  31. Brain-gut circadian rhythm interactions in alcohol-induced gut leakiness
    Fred W Turek; Fiscal Year: 2013
    ..Our hypothesis is supported by: (1) Gut leakiness is a major contributor to endotoxemia and gut-derived endotoxin is required for ASH;(2) while EtOH universally disrupts intestinal epithelial ..
  32. Role of Dab2 in Fatty Liver Disease
    Norbert Leitinger; Fiscal Year: 2013
    ..signalling pathway and deletion of Dab2 in myeloid cells in mice resulted in protection of the liver against endotoxemia and high fat diet- induced steatosis...
  33. Sp1 As a Novel Protective Mechanism Against Septic inflammation And Organ Injury.
    Shu Fang Liu; Fiscal Year: 2010
    ..We recently discovered that endotoxemia or sepsis down-regulates Sp1 (specificity protein 1) DNA binding activity and depletes tissue Sp1 protein in ..
  34. The Role of Direct Pathogen Detection by Sensory Neurons in Combating Bacterial I
    ISAAC MING CHENG CHIU; Fiscal Year: 2012
    ..These mice will be tested in two clinically relevant models of LPS induced endotoxemia and Streptococcus Pneumoniae bacterial infection...
  35. SsnB, a Chinese herb-derived selective TLR antagonist
    Daping Fan; Fiscal Year: 2013
    ..first evaluate the in vivo toxicity of SsnB and then test if SsnB can suppress the inflammatory responses in endotoxemia and sepsis mouse models. SA2...
  36. The Role of Adipose Tissue in Age-dependent Sensitivity to Critical Illness
    Hiroshi Saito; Fiscal Year: 2013
    ..For these studies we will use two widely accepted mouse models of SIRS - acute endotoxemia induced by injection with bacterial endotoxin lipopolysaccharide and an intra-abdominal sepsis model induced by ..
  37. ASDAMTS-13 and Inflammation
    TRUNG CHANH NGUYEN; Fiscal Year: 2012
    ..autoantibodies and VWF, are present in plasma of septic patients that contribute to acquired ADAMTS-13 deficiency;and 3) rADAMTS-13 and its truncated variant could improve survival in mouse models of endotoxemia and experimental sepsis.
  38. Heme Oxygenase-1/Carbon Monoxide in sepsis
    Augustine M Choi; Fiscal Year: 2013
    ..To examine these relationships, we propose the following hypothesis: CO confers cyto- and tissue protection in endotoxemia/sepsis by preserving cellular homeostasis and promoting bacterial clearance through molecular regulation and ..
  39. A molecular basis for endotoxin mediated insulin resistance
    SOPHIE HUSSEY; Fiscal Year: 2013
    ..that intestinal microbiota is the source of the excessive LPS observed in insulin resistant subjects (metabolic endotoxemia)...
  40. Annexin A2 and Protein p11 in Endotoxemia and Sepsis
    KATHERINE AMBERSON HAJJAR; Fiscal Year: 2013
    ..studies, we have found that while A2-/- mice have greater accumulations of microvascular fibrin during endotoxemia, they have unexpectedly reduced levels of tissue inflammation, despite extremely elevated levels of the pro-..
  41. Early inflammatory responses to high saturated fat diet
    Christina Camell; Fiscal Year: 2012
    ..of HSF diet results in neutrophil infiltration of murine adipose tissues, and a single meal induces transient endotoxemia and leukocyte activation in humans...
  42. Macrophage Gene Expression in Acute Lung Inflammation
    John W Christman; Fiscal Year: 2013
    ..1 in mice greatly attenuates lung inflammation and permeability edema in response to endotoxemia. Our supportive data indicate that PU...
  43. The effects of A2A adenosine receptor agonists in sepsis
    CHRISTOPHER CHARLES MOORE; Fiscal Year: 2010
    ..nitric oxide synthase, and nitric oxide in the beneficial survival effects of A2A AR agonists during murine endotoxemia and septic shock;AIM 2 will identify the molecular pathways that underpin the clinical manifestations of sepsis ..
  44. Post-Traumatic Sepsis: Regulation of LPS Binding Protein
    Timothy R Billiar; Fiscal Year: 2013
    ..a novel TLR4-signaling complex on HC contributes to HC LPS uptake and LPS clearance from the circulation during endotoxemia and sepsis...
  45. Xenobiotic Transporter Regulation and IRIP Function
    Yan Shu; Fiscal Year: 2013
    ..the role of IRIP in regulation of drug disposition during fatty liver disease, lipopolysaccharide-induced endotoxemia and ischemia/ reperfusion injury...
  46. Effect of ethanol on Kupffer cell/hepatocyte interactions and lipid metabolism
    Suthat Liangpunsakul; Fiscal Year: 2012
    ..Ethanol can induce endotoxemia. Lipopolysaccharide (LPS), a component of endotoxin, can stimulate Kupffer cells (KC), to produce cytokines...
  47. Regulation of Toll-like Receptor 4 in Acute Inflammatory Disease
    JUSTIN EDDIE JUSKEWITCH; Fiscal Year: 2012
    ..intact ECM in vitro;2) Establish the in vivo role of intact ECM and its degradation in 3 murine models of SIRS (endotoxemia, cerulein-induced acute pancreatitis, acetaminophen-induced acijte hepatitis)...
  48. Role of RAGE in Transfusion Mediated Acute Lung Injury
    NILAM S MANGALMURTI; Fiscal Year: 2013
    ..In Specific Aim 3, the mechanisms by which stored RBCs induce lung injury during endotoxemia will be explored using mouse models...
  49. Role of slowly digestible starch in diabetes risk factors in pre-diabetic people
    Eric Ravussin; Fiscal Year: 2013
    ..shown that the ingestion of slow digestible starch: a) enhances the gut microbial profile; b) reduces metabolic endotoxemia; c) increases fermentation and production of butyrate &propionate; d) increases beneficial gut hormones ..
  50. Osteopontin regulates ubiquitin-proteasome degradation of STAT1
    Paul C Kuo; Fiscal Year: 2012
    ..Utilizing both in vivo and in vitro murine models of endotoxemia (LPS), we have previously demonstrated that NO feedback inhibits its own synthesis by increasing transcription ..
  51. Lysosomal Damage, Impaired Autophagy, and Alcoholic Pancreatitis
    Olga A Mareninova; Fiscal Year: 2013
    ..We propose that similar mechanism mediates pancreatitis induced by the combination of ethanol feeding and endotoxemia (i.e., LPS), the other available "in vivo sensitization" model of alcoholic pancreatitis...
  52. SUBSTANCE P-MEDIATED CARDIOVASCULAR INFLAMMATION
    William Weglicki; Fiscal Year: 2009
    ..2 Confirm the importance of NEP status in SP-mediated inflammation and associated endotoxemia in the development of cardiac dysfunction during MgD, by using genetically manipulated murine models [NEP(-/-) ..
  53. PCBs worsen obesity/metabolic syndrome through 'toxic metabolic endotoxemia'
    MATTHEW C CAVE; Fiscal Year: 2013
    ..We call this problem "toxic-metabolic endotoxemia"...
  54. EGFR Tyrosine Kinase Inhibition - Induced Cardiomyopathy
    William Bernard Weglicki; Fiscal Year: 2013
    ..hypomagnesemia can trigger a significant production/release of substance P (SP) with resultant intestinal (endotoxemia) toxicity and cardiac dysfunction (decreased % FS &LVEF)...
  55. Zinc supplementation in alcoholic cirrhosis
    MATTHEW C CAVE; Fiscal Year: 2013
    ..The primary endpoints are reduction in (i) serum endotoxemia and (ii) ex vivo basal and endotoxin-stimulated TNF1 production...
  56. Gut Microbiota and Atherosclerosis in ESRD
    DOMINIC S RAJ; Fiscal Year: 2013
    ..Pentoxifylline (PTX) blocks cytokine generation in response to endotoxemia at the tissue level, and hence complements the actions of p-inulin...
  57. Human translational studies of CXCL12: a novel GWAS atherosclerosis locus
    Nehal N Mehta; Fiscal Year: 2011
    ..Second, does genetic variation in the CXCL12 region modulate endotoxemia-evoked adipose mRNA expression, plasma CXCL12 protein levels and inflammatory responses in vivo? This will be ..
  58. Circulating Tissue Factor: Characterization and Interactions with Factor IX
    LISA DIANE WILSBACHER; Fiscal Year: 2010
    ..endothelial and hematopoietic Tf is necessary for disseminated intravascular coagulation in mouse models of endotoxemia. However, the normal role of endothelial and hematopoietic TF in homeostasis and in inflammatory states is ..
  59. Elucidation of Tissue-Specific Transcriptomic Profiles in Cardiometabolic Disease
    Muredach P Reilly; Fiscal Year: 2013
    ..In the Genetics of Evoked-Responses to Niacin and Endotoxemia (GENE) study, we recruited healthy individuals (N=286) to an inpatient protocol and collected blood and adipose ..
  60. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2006
    Sepsis and endotoxemia are associated with increased production of IL-6 in intestinal mucosa and enterocytes, a response that is augmented by the heat shock response...
  61. Innate Modulation of Macrophage Homeostasis
    Liwu Li; Fiscal Year: 2013
    ..However, the underlying mechanism is not well understood. We observed that subclinical low grade endotoxemia potently represses cholesterol export from macrophages through reducing the expression of ABCA1/ABCG1, key ..
  62. Endotoxin TLR4 Signaling Regulates Lung Endothelial Paracellular Pathway
    SIMEON EMANUEL GOLDBLUM; Fiscal Year: 2012
    Gram-negative bacterial bloodstream infections and their attendant endotoxemia are associated with vascular leak syndromes, including the life-threatening, Acute Respiratory Distress Syndrome (ARDS)...
  63. COMPLEMENT-DEPENDENT PROSTAGLANDIN SYNTHESIS IN SEPSIS
    Mitchell Fink; Fiscal Year: 1991
    ..The studies will employ a rabbit model of endotoxemia that is characterized by low systemic vascular resistance and high cardiac output; i.e...
  64. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2007
    ..induction of HO-1 provides cytoprotection both in vivo and in vitro against multiple modes of injury including endotoxemia, ischemia/reperfusion, and hemorrhage...
  65. Sympathetic Regulation of Endotoxemia in Drug Abuse
    MARK KNUEPFER; Fiscal Year: 2005
    DESCRIPTION: Host defense responses to endotoxemia vary in individuals...
  66. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2009
    ..that administration of anticoagulants or anti-inflammatory agents reduces mortality in animal models of endotoxemia and sepsis...
  67. Sepsis syndrome and adenosine A2A receptor activation
    WILLIAM SCHELD; Fiscal Year: 2007
    ..We have found that A2A adenosine receptor (A2AAR) agonists are strongly protective in mouse models of endotoxemia and following live bacterial challenge resulting in septic shock...
  68. Novel Treatment for Septicemia Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2004
    ..Following its release from Gram-negative bacteria, elevated levels of endotoxin in the plasma (endotoxemia) causes acute organ damage, including acute lung injury (ALl) and death. Endacea, Inc...
  69. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    ..Until the late 1980s, sepsis was considered by many to be near-synonymous with gram-negative endotoxemia. However, in the early 1990s, it became more and more obvious that the concept of sepsis can arise from ..
  70. Ethyl Pyruvate: A Novel Treatment for Sepsis
    RUSSELL DELUDE; Fiscal Year: 2006
    ..as a therapeutic agent to treat rodents subjected to mesenteric ischemia and reperfusion, hemorrhagic shock, endotoxemia, or polymicrobial bacterial sepsis...