endotoxemia

Summary

Summary: A condition characterized by the presence of endotoxins in the blood. If endotoxemia is the result of gram-negative rod-shaped bacteria, shock may occur.

Top Publications

  1. ncbi Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
  2. doi Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
  3. ncbi Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Av E Mounier, 73 69, 1200 Brussels, Belgium
    Diabetologia 50:2374-83. 2007
  4. ncbi A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation
    Clett Erridge
    Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, United Kingdom
    Am J Clin Nutr 86:1286-92. 2007
  5. pmc A high-fat diet is associated with endotoxemia that originates from the gut
    Swaroop Pendyala
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10065, USA
    Gastroenterology 142:1100-1101.e2. 2012
  6. pmc Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation
    Subhabrata Basu
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio, USA
    Obesity (Silver Spring) 19:476-82. 2011
  7. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
  8. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
  9. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
  10. pmc Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009

Research Grants

  1. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
  2. A Novel Drug for Septicemia Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2009
  3. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2010
  4. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2005
  5. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2004
  6. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2006
  7. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2003
  8. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2010
  9. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2002
  10. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 1990

Detail Information

Publications337 found, 100 shown here

  1. ncbi Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
    ..We found that normal endotoxemia increased or decreased during the fed or fasted state, respectively, on a nutritional basis and that a 4-week ..
  2. doi Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 57:1470-81. 2008
    ..We previously determined, first, that metabolic endotoxemia controls the inflammatory tone, body weight gain, and diabetes, and second, that high-fat feeding modulates gut ..
  3. ncbi Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Av E Mounier, 73 69, 1200 Brussels, Belgium
    Diabetologia 50:2374-83. 2007
    ..caecal content in mice. We therefore tested whether restoration of the quantity of caecal Bifidobacterium spp. could modulate metabolic endotoxaemia, the inflammatory tone and the development of diabetes...
  4. ncbi A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation
    Clett Erridge
    Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, United Kingdom
    Am J Clin Nutr 86:1286-92. 2007
    ..Endotoxin circulates at low concentrations in the blood of all healthy individuals, although elevated concentrations are associated with an increased risk of atherosclerosis...
  5. pmc A high-fat diet is associated with endotoxemia that originates from the gut
    Swaroop Pendyala
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10065, USA
    Gastroenterology 142:1100-1101.e2. 2012
    b>Endotoxemia, characterized by an excess of circulating bacterial wall lipopolysaccharide, is associated with systemic inflammation and the metabolic syndrome...
  6. pmc Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation
    Subhabrata Basu
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio, USA
    Obesity (Silver Spring) 19:476-82. 2011
    ..to characterize the immune responses developed by the adipose tissue (AT) and their potential links to maternal endotoxemia in pregnancy with obesity...
  7. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ..stimulation fails to inhibit tumor necrosis factor (TNF) production in splenectomized animals during lethal endotoxemia. Selective lesioning of the common celiac nerve abolishes TNF suppression by vagus nerve stimulation, ..
  8. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia)...
  9. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
    ..This study sought to explore potential mechanisms of inflammatory-induced IR in humans with a focus on adipose tissue...
  10. pmc Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
    ..Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin is the necessary ..
  11. pmc The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
    Chunzhang Cao
    Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 120:1971-80. 2010
    ..Using an LPS-induced mouse model of lethal endotoxemia, we showed that APC administration reduced the mortality of wild-type mice, but not CD11b-deficient mice...
  12. pmc Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice
    Edward Kerschen
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Clin Invest 120:3167-78. 2010
    Activated protein C (aPC) therapy reduces mortality in adult patients with severe sepsis. In mouse endotoxemia and sepsis models, mortality reduction requires the cell signaling function of aPC, mediated through protease-activated ..
  13. pmc SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance
    Lei Cai
    Department of Internal Medicine, Cardiovascular Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Clin Invest 118:364-75. 2008
    ..We conclude that SR-BI in mice is required for the antiinflammatory response to LPS-induced endotoxic shock, likely through its essential role in facilitating glucocorticoid production and LPS hepatic clearance...
  14. doi Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia
    Janesh Pillay
    Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    J Leukoc Biol 88:211-20. 2010
    ....
  15. pmc Endotoxemia is associated with an increased risk of incident diabetes
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Diabetes Care 34:392-7. 2011
    ..Diabetes is accompanied with a chronic low-grade inflammation, which may in part be mediated by endotoxins derived from Gram-negative bacteria...
  16. doi In vivo profile of the human leukocyte microRNA response to endotoxemia
    Wolfgang M Schmidt
    Department of Clinical Pharmacology, Division of Pharmacogenetics and Imaging, Medical University of Vienna, A 1090 Vienna, Austria
    Biochem Biophys Res Commun 380:437-41. 2009
    ..associated with the pronounced down-regulation of the B-cell CLL/lymphoma 2 (BCL2) gene expression during LPS endotoxemia, and could further be involved in the translational silencing of several other predicted inflammation-related ..
  17. ncbi VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNgamma synthesis by T cells
    M Delgado
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102 1811, USA
    J Neuroimmunol 96:167-81. 1999
    ..The presence of VIP/PACAP in the lymphoid organs and the specific effects on cytokine production offer a physiological basis for their immunomodulatory role in vivo...
  18. pmc Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia
    Manjula Karpurapu
    Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Illinois, Chicago, 60612, USA
    Blood 118:5255-66. 2011
    ..1-deficient mice, establishing a novel protective mechanistic role for the lineage-specific transcription factor PU.1...
  19. ncbi A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse
    Takayuki Iwaki
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Blood 105:2364-71. 2005
    ....
  20. ncbi Systemic endotoxemia during chronic viral hepatitis
    A S Sozinov
    Kazan State Medical University
    Bull Exp Biol Med 133:153-5. 2002
    Incidence and severity of systemic endotoxemia in patients with chronic viral hepatitis B and C were studied using the limulus test. Healthy subjects and patients with acute viral hepatitis B and C comprised reference groups...
  21. pmc Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals
    Anne Roslev Bukh
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    PLoS ONE 6:e21275. 2011
    ..Microbial translocation may contribute to the immunopathogenesis in HIV infection. We investigated if microbial translocation and inflammation were associated with innate and adaptive immune responses in adults with HIV...
  22. pmc Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia
    Philipp Wiesner
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0682, USA
    Circ Res 107:56-65. 2010
    ..In addition, low-level but persistent metabolic endotoxemia is often found in diabetic and obese subjects and is induced in mice fed a high-fat diet.
  23. pmc A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes Care 33:1925-32. 2010
    Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis of obesity and metabolic risk...
  24. ncbi Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress
    H Jaeschke
    Department of Pharmacology, Pharmacia and Upjohn, Inc, Kalamazoo, MI, USA
    Hepatology 29:443-50. 1999
    ..Thus, strengthening defense mechanisms against ROS in target cells can attenuate excessive inflammatory injury without affecting host defense reactions...
  25. ncbi Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation
    D I Campbell
    Medical Research Council, Keneba, The Gambia
    J Nutr 133:1332-8. 2003
    ..These data are consistent with the hypothesis of translocation of immunogenic lumenal macromolecules across a compromised gut mucosa, leading to stimulation of systemic immune/inflammatory processes and subsequent growth impairment...
  26. ncbi Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis
    R C Reddy
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0360, USA
    Am J Physiol Lung Cell Mol Physiol 281:L537-43. 2001
    ..were performed to evaluate the effect of cyclooxygenase (COX)-2-specific inhibition on the outcome in murine endotoxemia and cecal ligation and puncture (CLP)...
  27. pmc Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cells
    Daniel Onguru
    Vector Biology and Control Research Centre, Kenya Medical Research Institute, Kisian, Kenya
    Am J Trop Med Hyg 84:321-4. 2011
    ..We show that schistosomiasis is associated with extremely high levels of endotoxemia as well as high mobility group 1, an endogenous inflammatory TLR ligand, in the absence of other coinfected ..
  28. ncbi TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis
    A A Dias
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    J Leukoc Biol 69:928-36. 2001
    ..The data shown here are the first in vivo evidence of the involvement of TSG-14 in the inflammatory process and suggest a role for TSG-14 in the defense against bacterial infections...
  29. ncbi Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 35:1139-44. 2007
    ..Here we studied whether GTS-21, a selective alpha7-nicotinic acetylcholine receptor agonist, inhibits proinflammatory cytokines in vitro and in vivo and improves survival in murine endotoxemia and severe sepsis.
  30. doi Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
    Marina C Pils
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 40:443-8. 2010
    ..We show that, in an IL-10-dependent LPS model of endotoxemia, dampening of the immune response requires expression of IL-10R1 in monocytes/macrophages and/or neutrophils ..
  31. pmc Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia
    Mohamed Lamkanfi
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    J Immunol 185:4385-92. 2010
    ..This finding indicates the existence of another caspase 1-dependent mediator of endotoxemia. Reduced serum high mobility group box 1 (HMGB1) levels in caspase 1-deficient mice correlated with their ..
  32. pmc Circulating endotoxemia: a novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease
    Christopher W McIntyre
    Department of Renal Medicine, Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3NE, United Kingdom
    Clin J Am Soc Nephrol 6:133-41. 2011
    ..This study's aim was to investigate endotoxemia across the spectrum of chronic kidney disease (CKD).
  33. ncbi Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study
    C J Wiedermann
    Department of Internal Medicine, Medical Faculty, University of Innsbruck, Austria
    J Am Coll Cardiol 34:1975-81. 1999
    ..Focus of the current study was on the significance of bacterial endotoxin, which shows a variety of pro-atherogenic properties and may occur at high concentration in the circulation of infected subjects...
  34. ncbi Innate immunity modulates adipokines in humans
    Paul D Anderson
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Endocrinol Metab 92:2272-9. 2007
    ..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...
  35. doi Reduced caloric intake during endotoxemia reduces arginine availability and metabolism
    Martijn Poeze
    Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Clin Nutr 91:992-1001. 2010
    ..Availability of arginine may further decrease during reduced caloric intake, which thereby limits the adaptive response of arginine-nitric oxide metabolism during sepsis...
  36. ncbi Proinflammatory effects of IL-10 during human endotoxemia
    F N Lauw
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:2783-9. 2000
    ..These data indicate that high-dose IL-10 treatment in patients with inflammatory disorders can be associated with undesired proinflammatory effects...
  37. ncbi Release of urokinase plasminogen activator receptor during urosepsis and endotoxemia
    S Florquin
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Kidney Int 59:2054-61. 2001
    ..The urokinase receptor (uPAR; CD87) is a multifunctional molecule involved in fibrinolysis, in proteolysis, in renal tubular functions, and in migration and adhesion of inflammatory cells to the site of infection...
  38. ncbi Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia
    Wim van der Meer
    Department of Clinical Chemistry, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Endotoxin Res 13:94-100. 2007
    ..of neutrophil membrane CD64 expression were examined during a standardized inflammatory response, using a human endotoxemia model, and compared with hematological indices, CRP, cytokines and interleukins...
  39. ncbi Local expression of tumor necrosis factor-alpha and interleukin-10 on wound healing of intestinal anastomosis during endotoxemia in mice
    Ken Ishimura
    First Department of Surgery, Kagawa Medical University, 1750 1, Ikenobe, Miki, Kita, Kagawa, 761 0793, Japan
    J Surg Res 108:91-7. 2002
    ....
  40. ncbi Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines
    Sumana Chakravarty
    Section on Functional Neuroanatomy, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 25:1788-96. 2005
    ..Our findings demonstrate a requirement for TLR4 function in CNS-resident cells, independent of systemic cytokine effects, for sustained CNS-specific inflammation and corticosterone rise during endotoxemia.
  41. doi Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus
    Scott V Monte
    State University of New York at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Amherst, NY, USA
    Surgery 151:587-93. 2012
    ..Because RYGB may diminish LPS from endogenous and exogenous sources, we hypothesized that LPS and the associated cascade of oxidative and inflammatory stress would diminish after RYGB...
  42. ncbi Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13
    T van der Poll
    Cornell University Medical College, Department of Surgery, New York, New York 10021, USA
    J Infect Dis 175:118-22. 1997
    ..IL-13 remained undetectable in the vast majority of patients and was not induced by endotoxin. Enhanced IL-13 production does not seem to be part of an inducible host defense mechanism during sepsis...
  43. doi Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2
    Julie Audoy-Rémus
    Department of Oncology and Molecular Endocrinology, Laval University Hospital Research Center, Quebec City, Quebec, Canada
    J Neurosci 28:10187-99. 2008
    ..provide evidence that CD68(+)GR1(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endothelium, these monocytes start to crawl, adopt a rod-shaped morphology when passing ..
  44. ncbi The sympathetic-vagal balance against endotoxemia
    Jian Huang
    Intensive Care Unit, Trauma Center of PLA, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    J Neural Transm 117:729-35. 2010
    ..We established an endotoxemia model in Sprague-Dawley rats using lipopolysaccharide (LPS) injection...
  45. ncbi Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia
    Bengt Age Sørby Borge
    Dept of Biomedicine, Univ of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Am J Physiol Heart Circ Physiol 296:H735-44. 2009
    ..The role of skeletal muscle myocytes as a source for cytokines during endotoxemia was explored by collecting muscle ISF using a wick method, and the levels of 14 cytokines in ISF and plasma ..
  46. doi Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation
    Fabienne Laugerette
    INRA UMR1235, RMND, Villeurbanne, F 69621 France
    J Nutr Biochem 22:53-9. 2011
    ..study, we first investigated in humans the impact of a mixed meal containing dispersed lipids on postprandial endotoxemia and inflammation...
  47. ncbi Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance
    J M Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona IdIBGi and University Hospital Dr Josep Trueta, CIBER Fisiopatología de la Obesidad y Nutrición CB06 03 010, Girona, Catalonia, Spain
    Int J Obes (Lond) 34:240-9. 2010
    ..We hypothesized that endotoxin (lipopolysaccharide, LPS) and fat intake were in the background of these associations...
  48. ncbi The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid
    Virginia Vanasco
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Free Radic Res 42:815-23. 2008
    ..to study the mitochondrial function and to evaluate (a) the oxidative stress in real time in an acute model of endotoxemia and (b) the effect of alpha-lipoic acid (LA, 100 mg/kg) as a therapeutic strategy to be considered...
  49. pmc Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway
    Hidefumi Komura
    Department of Surgery, North Shore University Hospital and The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 182:581-7. 2009
    ..In addition, endotoxemia was elicited by i.p. injection of LPS...
  50. ncbi Microcirculatory endothelial dysfunction during endotoxemia--insights into pathophysiology, pathologic mechanisms and clinical relevance
    Marcus Czabanka
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Curr Vasc Pharmacol 5:266-75. 2007
    ..This review considers endothelial cell dysfunction during endotoxemia including current insights into sepsis pathophysiology...
  51. ncbi NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia
    Jaspreet S Gujral
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Physiol Gastrointest Liver Physiol 287:G243-52. 2004
    Neutrophils can cause liver injury during endotoxemia through generation of reactive oxygen species. However, the enzymatic source of the oxidant stress and the nature of the oxidants generated remain unclear...
  52. pmc The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia
    Xianxi Wang
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Ohio, USA
    Life Sci 83:671-80. 2008
    ..The specific aim of the present study is to understand the role of Mkp-1 in the anti-inflammatory function of glucocorticoids...
  53. pmc Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response
    Elena Gonzalez-Rey
    Instituto de Parasitologia y Biomedicina, Consejo Superior de Investigaciones Cientificas, Avd Conocimiento, Parque Tecnologico Ciencias de la Salud, Granada 18100, Spain
    Am J Pathol 168:1921-30. 2006
    ..Importantly, UCN or AM treatment was therapeutically effective in established endotoxemia. In conclusion, UCN and AM could represent two multistep therapeutic agents for human septic shock to be used ..
  54. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
  55. doi Low-grade endotoxemia in patients with severe autism
    Enzo Emanuele
    Department of Health Sciences, Section of Psychiatry, University of Pavia, via Bassi, 21, I 27100, Pavia, Italy
    Neurosci Lett 471:162-5. 2010
    ..Whether increased endotoxin may contribute to the pathophysiology of inflammation and impaired reciprocal social interaction in autism should be further explored in future studies...
  56. doi Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia
    Anne Sofie Andreasen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, University Hospital Rigshospitalet, Rigshospitalet M 7641, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Intensive Care Med 36:1548-55. 2010
    ..This may partly be due to immune dysfunction. We investigated the in vivo innate immune response of type 2 diabetic persons to an intravenous injection of E. coli lipopolysaccharide (LPS)...
  57. ncbi Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  58. pmc Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    Ece Mutlu
    Rush University Medical Center, Division of Digestive Diseases and Nutrition, Nutrition Rush University Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 33:1836-46. 2009
    ..Although gut leakiness is clearly an important cause of endotoxemia in ALD, it cannot fully explain endotoxemia in all ALD subjects and thus other factors may be involved...
  59. pmc The influence of corticosteroids on the release of novel biomarkers in human endotoxemia
    Martijn D de Kruif
    Center for Experimental and Molecular Medicine, Room G2 132, Academic Medical Center, Meibergdreef 9, 1105 Amsterdam, AZ, The Netherlands
    Intensive Care Med 34:518-22. 2008
    ..However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone.
  60. pmc Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
    Yongseok Choi
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Exp Mol Med 40:574-81. 2008
    ..It also inhibited TNF-alpha production in vivo as demonstrated in a LPS-induced mouse endotoxemia model...
  61. ncbi Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease
    R K Rao
    Department of Physiology, University of Tennessee, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 286:G881-4. 2004
    A significant body of evidence indicates that endotoxemia and endotoxin-mediated hepatocellular damage play a crucial role in the pathogenesis of alcoholic liver disease...
  62. ncbi Human endotoxemia as a model of systemic inflammation
    A S Andreasen
    Centre of Inflammation and Metabolism, University of Copenhagen, Rigshospitalet 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Curr Med Chem 15:1697-705. 2008
    ..Finally, we outline the ethical considerations that apply to the use of human endotoxin model...
  63. ncbi Human endotoxemia: a model for mechanistic insight and therapeutic targeting
    Stephen F Lowry
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Shock 24:94-100. 2005
    ..By contrast, the model cannot predict clinical efficacy among higher risk patients nor in those who have endured extended periods of inflammatory stress...
  64. ncbi Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model
    Cornelis van 't Veer
    Center for Infection and Immunity Amsterdam, The Netherland
    J Immunol 179:7110-20. 2007
    ..In this study, we describe the expression kinetics of these LPS tolerance factors in standardized human endotoxemia models using i.v. LPS bolus administration...
  65. doi Cerebellar white matter injury following systemic endotoxemia in preterm fetal sheep
    J M Dean
    Department of Physiology and Neuroscience, Perinatal Centre, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Neuroscience 160:606-15. 2009
    ....
  66. ncbi GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat
    Laura Dugo
    Centre for Experimental Medicine, Nephrology and Critical Care Medicine, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, UK
    Crit Care Med 33:1903-12. 2005
    ..Here we investigate the effects of GSK-3beta inhibition on organ injury/dysfunction caused by lipopolysaccharide or coadministration of lipopolysaccharide and peptidoglycan in the rat...
  67. ncbi Energy intake is associated with endotoxemia in apparently healthy men
    Jacques Amar
    INSERM 558, Toulouse, France
    Am J Clin Nutr 87:1219-23. 2008
    ..The bridge between food intake and weight is not fully understood. Recently, the role of gut microbiota and bacterial lipopolysacharides (LPS) in weight has been noted...
  68. ncbi Inflammation impairs reverse cholesterol transport in vivo
    Fiona C McGillicuddy
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 119:1135-45. 2009
    ..The present study presents the first integrated functional evidence that inflammation retards numerous components of RCT...
  69. ncbi Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers
    Lucas T van Eijk
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Crit Care Med 35:1464-9. 2007
    To determine gender differences in the innate immune response and vascular reactivity during human endotoxemia.
  70. ncbi Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney
    Patrick N Cunningham
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 168:5817-23. 2002
    ..Therefore, TNF is a key mediator of LPS-induced ARF, acting through its receptor TNFR1 in the kidney...
  71. pmc Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Exp Mol Pathol 83:177-87. 2007
    Acute endotoxemia is associated with production of acute phase proteins which regulate inflammatory responses to tissue injury...
  72. ncbi Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death
    Kuniaki Ejima
    Brigham and Women s Hospital, Pulmonary and Critical Care Medicine, 75 Francis St, Boston, MA 02115, USA
    FASEB J 17:1325-7. 2003
    ..The present study investigates the role of cyclooxygenase (COX)-2 in host responses to bacterial endotoxemia. After administration of Escherichia coli lipopolysaccharide, 50% of wild-type mice die within 96 h...
  73. pmc The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Nutr 136:360-5. 2006
    ..on endotoxin-induced HMGB1 release in vitro, and explored its therapeutic potential in animal models of lethal endotoxemia and sepsis [induced by cecal ligation and puncture (CLP)] in vivo...
  74. ncbi The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:5514-22. 2007
    ..Thus, our findings reveal a new host-protective function for this GTPase in the response to pathogenic encounter...
  75. doi Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia
    Masaru Nagato
    Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Crit Care Med 37:2181-6. 2009
    ..Therefore, the therapeutic efficacy of recombinant human soluble thrombomodulin (ART-123) administration on the production of inflammatory cytokines and the plasma level of HMGB1 was investigated in experimental endotoxemia.
  76. pmc The impact of antihypertensive drug therapy on endotoxemia in elderly patients with chronic kidney disease
    Stephen G John
    Department of Renal Medicine, Royal Derby Hospital, Derby, United Kingdom
    Clin J Am Soc Nephrol 6:2389-94. 2011
    ..We therefore studied ET after improvement of the overall CV milieu with introduction of optimized antihypertensive therapy (AHT)...
  77. doi Toll-like receptor 4 inhibitor TAK-242 attenuates acute kidney injury in endotoxemic sheep
    Johan Fenhammar
    Department of Anaesthesia and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
    Anesthesiology 114:1130-7. 2011
    ..This study was conducted to investigate the role of toll-like receptor 4 (TLR4) in mediating acute kidney injury in endotoxemic sheep using the selective TLR4 inhibitor TAK-242...
  78. pmc Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
    Mauricio Rosas-Ballina
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 105:11008-13. 2008
    ..Here, we show that vagus nerve stimulation during endotoxemia specifically attenuates TNF production by spleen macrophages in the red pulp and the marginal zone...
  79. ncbi Effects of anticoagulation on thrombopoietin release during endotoxemia
    P Jilma-Stohlawetz
    Department of Clinical Pharmacology, The Adhesion Research Group Elaborating Therapeutics, Vienna University School of Medicine, Austria
    J Lab Clin Med 137:64-9. 2001
    ..Therefore we set out to illuminate the mechanism of TPO release in the setting of experimental endotoxemia, which induces activation of coagulation and platelets...
  80. ncbi Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-kappaB DNA binding, and improves short-term survival in lethal endotoxemia
    John A Kellum
    Mechanisms and Novel Therapies for Resuscitation and Acute Illness MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:801-5. 2004
    ..Because adsorptive capacity of hollow-fiber dialyzers is limited, we sought to determine whether hemoadsorption using high surface area beads would result in greater mediator removal and improved survival in experimental sepsis...
  81. ncbi Role of ubiquitin-proteasome pathway in skeletal muscle wasting in rats with endotoxemia
    Jiake Chai
    Department of Burns and Plastic Surgery, Burns Institute, 304th Hospital, 100037 Beijing, China
    Crit Care Med 31:1802-7. 2003
    To investigate the mechanism of muscle protein breakdown under endotoxemia condition.
  82. doi Acute endotoxemia following transjugular intrahepatic stent-shunt insertion is associated with systemic and cerebral vasodilatation with increased whole body nitric oxide production in critically ill cirrhotic patients
    R Jalan
    Liver Failure Group, UCL Hepatology, Upper Third Medical School, UCL Medical School, Rowland Hill Street, Royal Free Hospital, London NW3 2PF, UK
    J Hepatol 54:265-71. 2011
    ..This study explored the hypothesis that TIPSS insertion results in acute endotoxemia which is associated with increased nitric oxide production resulting in systemic and cerebral vasodilatation.
  83. ncbi White matter injury following systemic endotoxemia or asphyxia in the fetal sheep
    Carina Mallard
    Perinatal Center, Department of Physiology and Pharmacology, Goteborg University, Gothenburg, Sweden
    Neurochem Res 28:215-23. 2003
    ..including the effect on oligodendrocytes, astrocytes, and microglia, following either systemic asphyxia or endotoxemia in fetal sheep at midgestation...
  84. pmc Migration inhibitory factor expression in experimentally induced endotoxemia
    M Bacher
    Picower Institute for Medical Research, Manhasset, New York 10021, USA
    Am J Pathol 150:235-46. 1997
    ..of MIF protein were detected preformed in various cell types and appeared to be released as a consequence of endotoxemia. In virtually all tissues examined, the loss of MIF protein 6 hours after lipopolysaccharide administration was ..
  85. doi Acute endotoxemia inhibits microvascular nitric oxide-dependent vasodilation in humans
    Rolf P Engelberger
    Division of Clinical Pathophysiology, Centre Hospitalier Universitaire Vaudois, and University of Lausanne, Switzerland
    Shock 35:28-34. 2011
    ..Our results show for the first time that experimental endotoxemia in humans causes a specific decrease in endothelial NO-dependent vasodilation in the microcirculation, which ..
  86. ncbi Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia
    Siaw Wei Ng
    Cardiovascular Biology Research Group, Department of Pharmacology, National University of Singapore, Singapore
    J Leukoc Biol 83:288-95. 2008
    b>Endotoxemia is a life-threatening, inflammatory condition that involves multiple organ injury and dysfunction...
  87. pmc Endotoxemia-induced inflammation and the effect on the human brain
    Mark van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500HB, The Netherlands
    Crit Care 14:R81. 2010
    ..Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described...
  88. doi Sevelamer carbonate reduces inflammation and endotoxemia in an animal model of uremia
    Aline B Hauser
    Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceição 1155, Curitiba, Brazil
    Blood Purif 30:153-8. 2010
    ..The aim of this study was to evaluate the ET-binding capacity of sevelamer carbonate in an animal model of renal failure...
  89. ncbi Calcitonin gene-related peptide inhibits local acute inflammation and protects mice against lethal endotoxemia
    Rachel Novaes Gomes
    Laboratorio de Imunofarmacologia, Departamento de Fisiologia e Farmacodinamica, Fundacao Oswaldo Cruz, Rio de Janeiro 21045 900, Brazil
    Shock 24:590-4. 2005
    ..These results suggest that activation of the CGRP receptor on macrophages during acute inflammation could be part of the negative feedback mechanism controlling the extension of acute inflammatory responses...
  90. ncbi Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia
    Mirrin J Dorresteijn
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Endotoxin Res 11:287-93. 2005
    Clinical experience suggests that the administration of fluids in human endotoxemia reduces symptoms...
  91. pmc Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia
    Jasimuddin Ahamed
    The Rockefeller University, New York, NY, USA
    Blood 109:5251-9. 2007
    ..The present study demonstrates a new role of the TF cytoplasmic domain in an autoregulatory pathway that controls LPS-induced TF expression in macrophages and procoagulant responses in endotoxemia.
  92. ncbi Dose effects of propofol on hemodynamic and cytokine responses to endotoxemia in rats
    Yasuhiro Takemoto
    Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Anesth 19:40-4. 2005
    ..The purpose of this study was to elucidate whether these beneficial effects of propofol on hemodynamics and cytokine responses were dose related...
  93. ncbi Beneficial effects of ApoA-I on LPS-induced acute lung injury and endotoxemia in mice
    Yi Jie Yan
    Department of Biochemistry, School of Pharmacy, Fudan University, Shanghai, 200032, China
    Life Sci 79:210-5. 2006
    ..effects of Apolipoprotein (ApoA-I), the major apolipoprotein of HDL, on LPS-induced acute lung injury (ALI) and endotoxemia. BALB/c mice were challenged with LPS, followed by ApoA-I or saline administration for 24h...
  94. ncbi Adverse effect of heparin on antithrombin action during endotoxemia: microhemodynamic and cellular mechanisms
    Johannes N Hoffmann
    Department of Surgery, Chirurgische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistr 15, D 81377 Munchen, Germany
    Thromb Haemost 88:242-52. 2002
    ..In Syrian golden hamsters normotensive endotoxemia was induced by 2 mg/kg endotoxin (LPS, E. coli) i.v. In a first group of animals, AT (AT, 250 IU/kg i.v...
  95. ncbi Effects of C1 esterase inhibitor administration on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation during experimental endotoxemia
    Christian Lehmann
    Klinik für Anästhesiologie und Intensivmedizin, Ernst Moritz Arndt Universitat Greifswald, F Loeffler Strasse 23, 17489 Greifswald, Germany
    Intensive Care Med 30:309-14. 2004
    To determine the effects of C1 esterase inhibitor (C1-INH) administration on intestinal functional capillary density, leukocyte adherence, and mesenteric plasma extravasation during experimental endotoxemia.
  96. ncbi The Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms influence the late inflammatory response in human endotoxemia
    Claudia Marsik
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Clin Chem 51:2178-80. 2005
  97. ncbi Role of nitric oxide in regulating the rat hypothalamic-pituitary-adrenal axis response to endotoxemia
    Catherine Rivier
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 992:72-85. 2003
    ..By contrast, the stimulatory effect of high doses of lipopolysaccharide on ACTH release depends, at least in part, on the ability of NO to upregulate PVN neuronal activity...
  98. ncbi Endotoxemia in coronary artery bypass surgery: a comparison of the off-pump technique and conventional cardiopulmonary bypass
    Naz Bige Aydin
    Division of Cardiovascular Surgery, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, University of Marmara, Istanbul, Turkey
    J Thorac Cardiovasc Surg 125:843-8. 2003
    The endotoxemia associated with cardiac surgery is thought to be dominantly influenced by the use of cardiopulmonary bypass...
  99. ncbi Glycoprotein IIB/IIIA-inhibition and microcirculatory alterations during experimental endotoxemia--an intravital microscopic study in the rat
    Andreas Walther
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Microcirculation 11:79-88. 2004
    Endothelial damage during early endotoxemia has been shown to be leukocyte-independent...
  100. ncbi Endotoxemia associated with intussusception and its diagnostic and surgical interventions
    K L Chan
    Department of Surgery Division of Pediatric Surgery, The University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Pediatr Surg Int 18:685-8. 2002
    To determine if and when intussusception results in endotoxemia and to evaluate whether diagnostic and surgical interventions of intussusception aggravate endotoxemia, intussusception was created in seven pigs during general anesthesia (..
  101. ncbi The mitochondrial interplay of ubiquinol and nitric oxide in endotoxemia
    Constanza L Lisdero
    Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, Argentina
    Methods Enzymol 382:67-81. 2004

Research Grants91

  1. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..L-97-1, as an adjunctive, anti-sepsis treatment in an animal model of polymicrobial sepsis, bacteremia, and endotoxemia (rat cecal ligation and puncture [CLP]). Administration of L-97-1 as a single intravenous (i.v...
  2. A Novel Drug for Septicemia Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2009
    ..L-97-1, as an adjunctive, anti-sepsis treatment in an animal model of polymicrobial sepsis, bacteremia, and endotoxemia (rat cecal ligation and puncture [CLP]). Administration of L-97-1 as a single intravenous (i.v...
  3. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2010
    ..and experimental studies indicates that elevated intestinal permeability to endotoxins and the resulting endotoxemia play a crucial role in the pathogenesis of alcoholic liver disease...
  4. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2005
    Sepsis and endotoxemia are associated with increased production of IL-6 in intestinal mucosa and enterocytes, a response that is augmented by the heat shock response...
  5. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2004
    Sepsis and endotoxemia are associated with increased production of IL-6 in intestinal mucosa and enterocytes, a response that is augmented by the heat shock response...
  6. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2006
    Sepsis and endotoxemia are associated with increased production of IL-6 in intestinal mucosa and enterocytes, a response that is augmented by the heat shock response...
  7. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2003
    Sepsis and endotoxemia are associated with increased production of IL-6 in intestinal mucosa and enterocytes, a response that is augmented by the heat shock response...
  8. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2010
    ..EGCG) effectively attenuated endotoxin-induced HMGB1 release, and improved animal survival in murine models of endotoxemia and sepsis when given intraperitoneally...
  9. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2002
    ..of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis, remote traumas, well as alcoholic hepatitis...
  10. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 1990
    ..is altered and contributes to certain pathophysiologic sequelae of endotoxic and septic shock; and (2) endotoxemia and endotoxin tolerance alter cellular lipoxygenase and cyclo- oxygenase metabolism...
  11. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2005
    ..of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis, remote traumas, well as alcoholic hepatitis...
  12. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2004
    ..of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis, remote traumas, well as alcoholic hepatitis...
  13. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2001
    ..of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis, remote traumas, well as alcoholic hepatitis...
  14. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2003
    ..of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis, remote traumas, well as alcoholic hepatitis...
  15. COMPLEMENT-DEPENDENT PROSTAGLANDIN SYNTHESIS IN SEPSIS
    Mitchell Fink; Fiscal Year: 1990
    ..The studies will employ a rabbit model of endotoxemia that is characterized by low systemic vascular resistance and high cardiac output; i.e...
  16. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 2009
    ..heterotrimeric guanine nucleotide inhibitory protein (G)?i2 exhibit an enhanced pro- inflammatory phenotype to endotoxemia and cecal ligation and puncture (CLP)-induced polymicrobial sepsis...
  17. Aldehydes in Alcohol-Induced Organ Injury
    ZHANXIANG contact ZHOU; Fiscal Year: 2010
    ..Alcohol consumption causes gut barrier disruption, leading to endotoxemia, which, in turn, causes tissue injury at the liver-brain axis by stimulating cytokine production...
  18. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2009
    Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
  19. TUBULAR CELL METABOLISM AND ANTBIOTIC NEPHROTOXICITY
    BRUCE TUNE; Fiscal Year: 1990
    ..after moderate dosage during certain high-risk states: combined use with aminoglycosides, or during endotoxemia or renal ischemia...
  20. HDL Modulation of monocyte function in endotoxemia
    C Roger White; Fiscal Year: 2010
    ..Collectively, these effects serve to reduce cell injury induced by sepsis. ..
  21. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
    ..Collectively, these effects serve to reduce cell injury induced by sepsis. ..
  22. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
    ..Collectively, these effects serve to reduce cell injury induced by sepsis. ..
  23. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2004
    ..induction of HO-1 provides cytoprotection both in vivo and in vitro against multiple modes of injury including endotoxemia, ischemia/reperfusion, and hemorrhage...
  24. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2007
    ..induction of HO-1 provides cytoprotection both in vivo and in vitro against multiple modes of injury including endotoxemia, ischemia/reperfusion, and hemorrhage...
  25. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2005
    ..induction of HO-1 provides cytoprotection both in vivo and in vitro against multiple modes of injury including endotoxemia, ischemia/reperfusion, and hemorrhage...
  26. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2004
    ..induction of HO-1 provides cytoprotection both in vivo and in vitro against multiple modes of injury including endotoxemia, ischemia/reperfusion, and hemorrhage...
  27. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2006
    ..induction of HO-1 provides cytoprotection both in vivo and in vitro against multiple modes of injury including endotoxemia, ischemia/reperfusion, and hemorrhage...
  28. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2010
    Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
  29. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2009
    ..The investigations will employ experimental models of endotoxemia and sepsis utilizing mouse strains that carry genetically silenced forms of these X-linked proteins...
  30. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2010
    ..The investigations will employ experimental models of endotoxemia and sepsis utilizing mouse strains that carry genetically silenced forms of these X-linked proteins...
  31. LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1999
    ..This should provide novel insights into the regulation of cytokine expression during gram negative sepsis while identifying mechanistic therapies to ameliorate acute lung injury and multiple organ failure. ..
  32. The Role of B Cells and B Cell Toll-like Receptors in Glucose Intolerance
    Barbara Nikolajczyk; Fiscal Year: 2010
    ..Because the general endotoxemia and elevated free fatty acids in T2D patients provide innumerable TLR ligands, our preliminary data predict ..
  33. Sympathetic Regulation of Endotoxemia in Drug Abuse
    MARK KNUEPFER; Fiscal Year: 2003
    DESCRIPTION: Host defense responses to endotoxemia vary in individuals...
  34. Sympathetic Regulation of Endotoxemia in Drug Abuse
    MARK KNUEPFER; Fiscal Year: 2002
    DESCRIPTION: Host defense responses to endotoxemia vary in individuals...
  35. Sympathetic Regulation of Endotoxemia in Drug Abuse
    MARK KNUEPFER; Fiscal Year: 2005
    DESCRIPTION: Host defense responses to endotoxemia vary in individuals...
  36. Sympathetic Regulation of Endotoxemia in Drug Abuse
    MARK KNUEPFER; Fiscal Year: 2004
    DESCRIPTION: Host defense responses to endotoxemia vary in individuals...
  37. Sympathetic Regulation of Endotoxemia in Drug Abuse
    MARK KNUEPFER; Fiscal Year: 2001
    DESCRIPTION: Host defense responses to endotoxemia vary in individuals...
  38. Angiopoietin Mechanisms in Sepsis
    Samir Parikh; Fiscal Year: 2009
    ..which is similar in structure to Ang-2 but has opposite signaling effects, prevents vascular leak in murine endotoxemia. To achieve this remarkable protective effect, Ang-1 must activate a regulatory protein in the Rho-GTPase ..
  39. Angiopoietin Mechanisms in Sepsis
    Samir Parikh; Fiscal Year: 2009
    ..which is similar in structure to Ang-2 but has opposite signaling effects, prevents vascular leak in murine endotoxemia. To achieve this remarkable protective effect, Ang-1 must activate a regulatory protein in the Rho-GTPase ..
  40. Angiopoietin Mechanisms in Sepsis
    Samir M Parikh; Fiscal Year: 2010
    ..which is similar in structure to Ang-2 but has opposite signaling effects, prevents vascular leak in murine endotoxemia. To achieve this remarkable protective effect, Ang-1 must activate a regulatory protein in the Rho-GTPase ..
  41. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2009
    ..that administration of anticoagulants or anti-inflammatory agents reduces mortality in animal models of endotoxemia and sepsis...
  42. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
    ..that administration of anticoagulants or anti-inflammatory agents reduces mortality in animal models of endotoxemia and sepsis...
  43. Sp1 As a Novel Protective Mechanism Against Septic inflammation And Organ Injury.
    Shu Liu; Fiscal Year: 2009
    ..We recently discovered that endotoxemia or sepsis down-regulates Sp1 (specificity protein 1) DNA binding activity and depletes tissue Sp1 protein in ..
  44. A molecular basis for endotoxin mediated insulin resistance
    SOPHIE HUSSEY; Fiscal Year: 2012
    ..that intestinal microbiota is the source of the excessive LPS observed in insulin resistant subjects (metabolic endotoxemia)...
  45. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 2009
    ..heterotrimeric quanine nucleotide inhibitory protein (G1i2) exhibit an enhanced pro- inflammatory phenotype to endotoxemia and cecal ligation and puncture (CLP)-induced polymicrobial sepsis...
  46. ROLE OF EICOSANOIDS IN SHOCK
    James A Cook; Fiscal Year: 2010
    ..heterotrimeric quanine nucleotide inhibitory protein (G1i2) exhibit an enhanced pro- inflammatory phenotype to endotoxemia and cecal ligation and puncture (CLP)-induced polymicrobial sepsis...
  47. Sepsis syndrome and adenosine A2A receptor activation
    WILLIAM SCHELD; Fiscal Year: 2007
    ..We have found that A2A adenosine receptor (A2AAR) agonists are strongly protective in mouse models of endotoxemia and following live bacterial challenge resulting in septic shock...
  48. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2006
    ..expression of CXCL9, 10 &l 1 and CXCR3 in distinct neuroinflammatory pathologies including: (i) LPS-induced endotoxemia, (ii) virus infection (i.e...
  49. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2009
    ..Anti-TNF agents are protective against lethal endotoxemia only if given prophylatically;whereas agents capable of inhibiting HMGB1 release or activity can rescue mice ..
  50. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2007
    ..Anti-TNF agents are protective against lethal endotoxemia only if given prophylatically; whereas agents capable of inhibiting HMGB1 release or activity can rescue mice ..
  51. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2007
    ..Anti-TNF agents are protective against lethal endotoxemia only if given prophylatically; whereas agents capable of inhibiting HMGB1 release or activity can rescue mice ..
  52. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2004
    ..expression of CXCL9, 10 &l 1 and CXCR3 in distinct neuroinflammatory pathologies including: (i) LPS-induced endotoxemia, (ii) virus infection (i.e...
  53. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2007
    ..expression of CXCL9, 10 &l 1 and CXCR3 in distinct neuroinflammatory pathologies including: (i) LPS-induced endotoxemia, (ii) virus infection (i.e...
  54. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2005
    ..expression of CXCL9, 10 &l 1 and CXCR3 in distinct neuroinflammatory pathologies including: (i) LPS-induced endotoxemia, (ii) virus infection (i.e...
  55. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2009
    ..and experimental studies indicates that elevated intestinal permeability to endotoxins and the resulting endotoxemia play a crucial role in the pathogenesis of alcoholic liver disease...
  56. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2006
    ..and experimental studies indicates that elevated intestinal permeability to endotoxins and the resulting endotoxemia play a crucial role in the pathogenesis of alcoholic liver disease...
  57. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2005
    ..and experimental studies indicates that elevated intestinal permeability to endotoxins and the resulting endotoxemia play a crucial role in the pathogenesis of alcoholic liver disease...
  58. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2007
    ..and experimental studies indicates that elevated intestinal permeability to endotoxins and the resulting endotoxemia play a crucial role in the pathogenesis of alcoholic liver disease...
  59. Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
    MARK PERRELLA; Fiscal Year: 2007
    ..The inducible form of nitric oxide synthase (NOS2) plays an important role in endotoxemia/sepsis through overproduction of nitric oxide (NO)...
  60. Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
    MARK PERRELLA; Fiscal Year: 2006
    ..The inducible form of nitric oxide synthase (NOS2) plays an important role in endotoxemia/sepsis through overproduction of nitric oxide (NO)...
  61. Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
    MARK PERRELLA; Fiscal Year: 2005
    ..The inducible form of nitric oxide synthase (NOS2) plays an important role in endotoxemia/sepsis through overproduction of nitric oxide (NO)...
  62. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 1992
    ..Among the most important pathophysiologic mediators released in endotoxemia are the eicosanoid, prostaglandins (PG), thromboxanes (TX), and leukotrienes (LT)...
  63. SRC FAMILY PROTEIN TYROSINE KINASES IN HEMATOPOIESIS
    Clifford Lowell; Fiscal Year: 2004
    ..in altered immune responses in knockout mice in vivo; hck-/-fgr-/- mutants suffer reduced tissue damage during endotoxemia and blunted development of inflammatory disease when crossed with motheaten mice...
  64. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 1993
    ..Among the most important pathophysiologic mediators released in endotoxemia are the eicosanoid, prostaglandins (PG), thromboxanes (TX), and leukotrienes (LT)...
  65. SRC FAMILY PROTEIN TYROSINE KINASES IN HEMATOPOIESIS
    Clifford Lowell; Fiscal Year: 2001
    ..in altered immune responses in knockout mice in vivo; hck-/-fgr-/- mutants suffer reduced tissue damage during endotoxemia and blunted development of inflammatory disease when crossed with motheaten mice...
  66. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 1991
    ..Among the most important pathophysiologic mediators released in endotoxemia are the eicosanoid, prostaglandins (PG), thromboxanes (TX), and leukotrienes (LT)...
  67. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2004
    ..In preliminary studies, The investigators found that hemorrhage or endotoxemia cause rapid increases in the expression of proinflammatory cytokines IL-1, TNF, and MIP-2, and in activation of ..
  68. SPLANCHNIC PERFUSION AND FUNCTION DURING ENDOTOXEMIA
    James Ferguson; Fiscal Year: 1993
    ..Future studies will use this information to determine how best to improve intestinal absorption, and reduce intestinal translocation of bacteria during septic shock...
  69. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2000
    ..In preliminary studies, The investigators found that hemorrhage or endotoxemia cause rapid increases in the expression of proinflammatory cytokines IL-1, TNF, and MIP-2, and in activation of ..
  70. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2001
    ..In preliminary studies, The investigators found that hemorrhage or endotoxemia cause rapid increases in the expression of proinflammatory cytokines IL-1, TNF, and MIP-2, and in activation of ..
  71. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2002
    ..In preliminary studies, The investigators found that hemorrhage or endotoxemia cause rapid increases in the expression of proinflammatory cytokines IL-1, TNF, and MIP-2, and in activation of ..
  72. Novel Treatment for Septicemia Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2004
    ..Following its release from Gram-negative bacteria, elevated levels of endotoxin in the plasma (endotoxemia) causes acute organ damage, including acute lung injury (ALl) and death. Endacea, Inc...
  73. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2003
    ..In preliminary studies, The investigators found that hemorrhage or endotoxemia cause rapid increases in the expression of proinflammatory cytokines IL-1, TNF, and MIP-2, and in activation of ..
  74. Role of Heme Oxygenase-1 in Sepsis
    MARK PERRELLA; Fiscal Year: 2009
    ..Until the late 1980s, sepsis was considered by many to be near-synonymous with gram-negative endotoxemia. However, in the early 1990s, it became more and more obvious that the concept of sepsis can arise from ..
  75. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    ..Until the late 1980s, sepsis was considered by many to be near-synonymous with gram-negative endotoxemia. However, in the early 1990s, it became more and more obvious that the concept of sepsis can arise from ..
  76. Brain-gut circadian rhythm interactions in alcohol-induced gut leakiness
    Fred W Turek; Fiscal Year: 2012
    ..Our hypothesis is supported by: (1) Gut leakiness is a major contributor to endotoxemia and gut-derived endotoxin is required for ASH;(2) while EtOH universally disrupts intestinal epithelial ..
  77. Brain-gut circadian rhythm interactions in alcohol-induced gut leakiness
    Fred W Turek; Fiscal Year: 2011
    ..Our hypothesis is supported by: (1) Gut leakiness is a major contributor to endotoxemia and gut-derived endotoxin is required for ASH;(2) while EtOH universally disrupts intestinal epithelial ..
  78. Ethyl Pyruvate: A Novel Treatment for Sepsis
    RUSSELL DELUDE; Fiscal Year: 2006
    ..as a therapeutic agent to treat rodents subjected to mesenteric ischemia and reperfusion, hemorrhagic shock, endotoxemia, or polymicrobial bacterial sepsis...
  79. Oral Antioxidant/Anticytokine Therapy for ALD
    Daniell Hill; Fiscal Year: 2002
    ..We postulate that chronic alcohol abuse causes increased gut permeability and endotoxemia, depletion of nutritional antioxidants (e.g...
  80. Oral Antioxidant/Anticytokine Therapy for ALD
    Daniell Hill; Fiscal Year: 2003
    ..We postulate that chronic alcohol abuse causes increased gut permeability and endotoxemia, depletion of nutritional antioxidants (e.g...
  81. Ethyl Pyruvate: A Novel Treatment for Sepsis
    Mitchell Fink; Fiscal Year: 2003
    ..as a therapeutic agent to treat rodents subjected to mesenteric ischemia and reperfusion, hemorrhagic shock, endotoxemia, or polymicrobial bacterial sepsis...
  82. Ethyl Pyruvate: A Novel Treatment for Sepsis
    Mitchell Fink; Fiscal Year: 2005
    ..as a therapeutic agent to treat rodents subjected to mesenteric ischemia and reperfusion, hemorrhagic shock, endotoxemia, or polymicrobial bacterial sepsis...
  83. Ethyl Pyruvate: A Novel Treatment for Sepsis
    Mitchell Fink; Fiscal Year: 2004
    ..as a therapeutic agent to treat rodents subjected to mesenteric ischemia and reperfusion, hemorrhagic shock, endotoxemia, or polymicrobial bacterial sepsis...
  84. Sp1 As a Novel Protective Mechanism Against Septic inflammation And Organ Injury.
    Shu Fang Liu; Fiscal Year: 2010
    ..We recently discovered that endotoxemia or sepsis down-regulates Sp1 (specificity protein 1) DNA binding activity and depletes tissue Sp1 protein in ..
  85. DNA Minor Groove-binding Drugs and Food-borne Pathogens
    MARK PERRELLA; Fiscal Year: 2007
    ..have the potential to spread from the gastrointestinal tract into the blood stream, resulting in bacteremia and endotoxemia, which has devastating consequences in patients...
  86. DNA Minor Groove-binding Drugs and Food-borne Pathogens
    MARK PERRELLA; Fiscal Year: 2006
    ..have the potential to spread from the gastrointestinal tract into the blood stream, resulting in bacteremia and endotoxemia, which has devastating consequences in patients...
  87. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
    ..that administration of anticoagulants or anti-inflammatory agents reduces mortality in animal models of endotoxemia and sepsis...