sepsis

Summary

Summary: The presence of pathogenic microorganisms or their toxins in tissues or in the blood. Systemic disease caused by the spread of the microorganisms via the circulating blood is commonly called SEPTICEMIA. (From Stedman, 25th ed)

Top Publications

  1. doi Statins for the prevention and treatment of infections: a systematic review and meta-analysis
    Imad M Tleyjeh
    Department of Medicine, King Fahd Medical City, Riyadh, Saudi Arabia
    Arch Intern Med 169:1658-67. 2009
  2. doi Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
    R Phillip Dellinger
    Cooper University Hospital, Camden, New Jersey, USA
    Crit Care Med 41:580-637. 2013
  3. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
  4. doi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012
    R P Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Intensive Care Med 39:165-228. 2013
  5. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
  6. ncbi The immunopathogenesis of sepsis
    Jonathan Cohen
    Brighton and Sussex Medical School, Westlain House, Falmer, UK
    Nature 420:885-91. 2002
  7. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
  8. ncbi CDC definitions for nosocomial infections, 1988
    J S Garner
    Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia
    Am J Infect Control 16:128-40. 1988
  9. pmc Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
    Intensive Care Med 34:17-60. 2008
  10. doi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012

Detail Information

Publications406 found, 100 shown here

  1. doi Statins for the prevention and treatment of infections: a systematic review and meta-analysis
    Imad M Tleyjeh
    Department of Medicine, King Fahd Medical City, Riyadh, Saudi Arabia
    Arch Intern Med 169:1658-67. 2009
    ..Our objective was to examine the association between statin use and the risk of infections and related outcomes...
  2. doi Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
    R Phillip Dellinger
    Cooper University Hospital, Camden, New Jersey, USA
    Crit Care Med 41:580-637. 2013
    To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008.
  3. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    To determine the incidence, cost, and outcome of severe sepsis in the United States.
  4. doi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012
    R P Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Intensive Care Med 39:165-228. 2013
    To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008.
  5. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
    b>Sepsis represents a substantial health care burden, and there is limited epidemiologic information about the demography of sepsis or about the temporal changes in its incidence and outcome...
  6. ncbi The immunopathogenesis of sepsis
    Jonathan Cohen
    Brighton and Sussex Medical School, Westlain House, Falmer, UK
    Nature 420:885-91. 2002
    b>Sepsis is a condition that results from a harmful or damaging host response to infection...
  7. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004.
  8. ncbi CDC definitions for nosocomial infections, 1988
    J S Garner
    Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia
    Am J Infect Control 16:128-40. 1988
    ..Other hospitals may wish to adopt or modify them for use in their nosocomial infections surveillance programs...
  9. pmc Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
    Intensive Care Med 34:17-60. 2008
    To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004.
  10. doi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
    Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis.
  11. ncbi Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
    Stephen R Clark
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Nat Med 13:463-9. 2007
    It has been known for many years that neutrophils and platelets participate in the pathogenesis of severe sepsis, but the inter-relationship between these players is completely unknown...
  12. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
    ..response to infection, which is a progressive injurious process that falls under the generalized term 'sepsis' and includes sepsis-associated organ dysfunction as well...
  13. pmc Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach
    Richard S Hotchkiss
    Department of Anesthesiology, Medicine, and Surgery Washington University School of Medicine, St Louis, MO, USA
    Lancet Infect Dis 13:260-8. 2013
    Failures of highly touted trials have caused experts to call for re-evaluation of the current approach toward sepsis. New research has revealed key pathogenic mechanisms; autopsy results have shown that most patients admitted to intensive ..
  14. ncbi Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatrics 110:285-91. 2002
    Late-onset sepsis (occurring after 3 days of age) is an important problem in very low birth weight (VLBW) infants...
  15. pmc Harmful molecular mechanisms in sepsis
    Daniel Rittirsch
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109 0602, USA
    Nat Rev Immunol 8:776-87. 2008
    b>Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and clinicians and are a tremendous burden for health-care systems...
  16. doi Combination biomarkers to diagnose sepsis in the critically ill patient
    Sebastien Gibot
    Hopital Central, Service de Reanimation Medicale, 29 Avenue du Marechal de Lattre de Tassigny, Nancy Cedex, France
    Am J Respir Crit Care Med 186:65-71. 2012
    Although the outcome of sepsis benefits from the prompt administration of appropriate antibiotics on correct diagnosis, the assessment of infection in critically ill patients is often a challenge for clinicians...
  17. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
    ..response to infection, which is a progressive injurious process that falls under the generalized term 'sepsis' and includes sepsis-associated organ dysfunction as well...
  18. doi The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
    Mitchell M Levy
    Division of Pulmonary, Sleep and Critical Care Medicine Care Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 38:367-74. 2010
    The Surviving Sepsis Campaign (SSC or "the Campaign") developed guidelines for management of severe sepsis and septic shock...
  19. ncbi Management of sepsis
    James A Russell
    University of British Columbia, Critical Care Medicine, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 355:1699-713. 2006
  20. doi Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial
    Steven M Opal
    Alpert Medical School of Brown University, Providence, Rhode Island, USA
    JAMA 309:1154-62. 2013
    ..LPS is a major component of the outer membrane of gram-negative bacteria and is a potent activator of the acute inflammatory response...
  21. pmc Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
    Fernando A Bozza
    ICU, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Av Brasil 4365, Rio de Janeiro, Brazil
    Crit Care 11:R49. 2007
    The current shortage of accurate and readily available, validated biomarkers of disease severity in sepsis is an important limitation when attempting to stratify patients into homogeneous groups, in order to study pathogenesis or develop ..
  22. pmc Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
    Rajesh K Thimmulappa
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 116:984-95. 2006
    Host genetic factors that regulate innate immunity determine susceptibility to sepsis. Disruption of nuclear factor-erythroid 2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that regulates redox balance and stress ..
  23. ncbi Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    JAMA 292:2357-65. 2004
    ..Neonatal infections are frequent complications of extremely low-birth-weight (ELBW) infants receiving intensive care...
  24. ncbi International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics
    Brahm Goldstein
    FCCM Oregon Health and Science University, Portland, OR, USA
    Pediatr Crit Care Med 6:2-8. 2005
    Although general definitions of the sepsis continuum have been published for adults, no such work has been done for the pediatric population...
  25. ncbi Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options
    C A Gogos
    Department of Medicine, Section of Infectious Diseases, Patras University Medical School, Patras, Greece
    J Infect Dis 181:176-80. 2000
    ..and IL-1 receptor antagonists (IL-1ra) and soluble TNF receptors (sTNFRs) were measured in 65 patients with severe sepsis. All patients were evaluated clinically and microbiologically and were followed up for clinical outcome...
  26. ncbi Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003
    Viktor Y Dombrovskiy
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Crit Care Med 35:1244-50. 2007
    To determine recent trends in rates of hospitalization, mortality, and hospital case fatality for severe sepsis in the United States.
  27. pmc Immunosuppression in patients who die of sepsis and multiple organ failure
    Jonathan S Boomer
    Department of Medicine, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    JAMA 306:2594-605. 2011
    Severe sepsis is typically characterized by initial cytokine-mediated hyperinflammation. Whether this hyperinflammatory phase is followed by immunosuppression is controversial...
  28. ncbi LPS induction of gene expression in human monocytes
    M Guha
    Departments of Immunology, C-204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Signal 13:85-94. 2001
    ..These signaling pathways in turn activate a variety of transcription factors that include NF-kappaB (p50/p65) and AP-1 (c-Fos/c-Jun), which coordinate the induction of many genes encoding inflammatory mediators...
  29. ncbi The pathophysiology and treatment of sepsis
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 348:138-50. 2003
  30. pmc Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    Huan Yang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 101:296-301. 2004
    Despite significant advances in intensive care therapy and antibiotics, severe sepsis accounts for 9% of all deaths in the United States annually...
  31. pmc Extracellular histones are major mediators of death in sepsis
    Jun Xu
    Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Nat Med 15:1318-21. 2009
    Hyperinflammatory responses can lead to a variety of diseases, including sepsis. We now report that extracellular histones released in response to inflammatory challenge contribute to endothelial dysfunction, organ failure and death ..
  32. doi Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis
    Christina Wacker
    Department of Medical Statistics, Computer Sciences and Documentation, Centre for Sepsis Control and Care, Jena University Hospital, Jena, Germany
    Lancet Infect Dis 13:426-35. 2013
    Procalcitonin is a promising marker for identification of bacterial infections. We assessed the accuracy and clinical value of procalcitonin for diagnosis of sepsis in critically ill patients.
  33. doi Benchmarking the incidence and mortality of severe sepsis in the United States
    David F Gaieski
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 41:1167-74. 2013
    In 1992, the first consensus definition of severe sepsis was published...
  34. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
    To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units.
  35. ncbi The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 101:3765-77. 2003
    Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high morbidity and mortality rates...
  36. pmc Neutrophil CD64 as a diagnostic marker in neonatal sepsis
    Iris Streimish
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Infect Dis J 31:777-81. 2012
    We assessed neutrophil CD64 as a diagnostic marker for neonatal sepsis. For early-onset sepsis, the CD64 index with a cut-point value of 2.38 had sensitivity, specificity and negative predictive values of 100%, 68% and 100%, respectively...
  37. pmc Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis
    Nancy Chou Macgarvey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 185:851-61. 2012
    ..damage is an important component of multiple organ failure syndrome, a highly lethal complication of severe sepsis that lacks specific therapy...
  38. pmc The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
    Mitchell M Levy
    Division of Pulmonary, Sleep and Critical Care Medicine, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Intensive Care Med 36:222-31. 2010
    The Surviving Sepsis Campaign (SSC or "the Campaign") developed guidelines for management of severe sepsis and septic shock...
  39. doi The effects of sepsis on mitochondria
    Gloria Garrabou
    Mitochondrial Research Laboratory, IDIBAPS, University of Barcelona, Internal Medicine Department, Hospital Clínic of Barcelona HCB, Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Valencia
    J Infect Dis 205:392-400. 2012
    b>Sepsis is associated with mitochondrial dysfunction and impaired oxygen consumption, which may condition clinical outcome independent of tissue oxygenation. However, mitochondrial role in sepsis severity remains unknown...
  40. pmc Sepsis biomarkers: a review
    Charalampos Pierrakos
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 14:R15. 2010
    Biomarkers can be useful for identifying or ruling out sepsis, identifying patients who may benefit from specific therapies or assessing the response to therapy.
  41. doi The endothelium: physiological functions and role in microcirculatory failure during severe sepsis
    H Ait-Oufella
    INSERM U970, PAris Research Cardiovascular Center, Paris, France
    Intensive Care Med 36:1286-98. 2010
    ..During severe sepsis, the endothelium becomes proadhesive, procoagulant, antifibrinolytic and is characterized by alterations of ..
  42. doi SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis
    Padmam Puneet
    Department of Physiology, National University of Singapore, 117597 Singapore
    Science 328:1290-4. 2010
    During sepsis, activation of phagocytes leads to the overproduction of proinflammatory cytokines, causing systemic inflammation...
  43. pmc Immunodesign of experimental sepsis by cecal ligation and puncture
    Daniel Rittirsch
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109, USA
    Nat Protoc 4:31-6. 2009
    b>Sepsis remains a prevalent clinical challenge and the underlying pathophysiology is still poorly understood...
  44. doi Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
    Serum lactate is a potentially useful biomarker to risk-stratify patients with severe sepsis; however, it is plausible that elevated serum lactate is simply a manifestation of clinically apparent organ dysfunction and/or shock (i.e...
  45. doi Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis
    Steve Lancel
    Department of Physiology, Institut de Médecine Prédictive et de Recherche Thérapeutique Institut Fédératif de Recherche, Universite de Lille 2, Faculte de Medecine, Lille, France
    J Pharmacol Exp Ther 329:641-8. 2009
    ..capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects...
  46. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  47. ncbi Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study
    Corinne Alberti
    Department of Biostatistics, Saint Louis Hospital, Paris, France
    Intensive Care Med 28:108-21. 2002
    ..To examine the incidence of infections and to describe them and their outcome in intensive care unit (ICU) patients...
  48. pmc The pathogenesis of sepsis
    Deborah J Stearns-Kurosawa
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Massachusetts 02218, USA
    Annu Rev Pathol 6:19-48. 2011
    b>Sepsis is a serious clinical condition that represents a patient's response to a severe infection and has a very high mortality rate...
  49. doi Serum miR-146a and miR-223 as potential new biomarkers for sepsis
    Jia Feng Wang
    Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Biochem Biophys Res Commun 394:184-8. 2010
    Current biomarkers cannot completely distinguish sepsis from systemic inflammatory response syndrome (SIRS) caused by other non-infectious diseases...
  50. pmc The late phase of sepsis is characterized by an increased microbiological burden and death rate
    Gordon P Otto
    Clinic for Anesthesiology and Intensive Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R183. 2011
    Recent models capturing the pathophysiology of sepsis and ex-vivo data from patients are speculating about immunosuppression in the so-called late phase of sepsis. Clinical data regarding survival and microbiological burden are missing...
  51. doi Proof of principle: the predisposition, infection, response, organ failure sepsis staging system
    Michael D Howell
    Pulmonary and Critical Care Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Crit Care Med 39:322-7. 2011
    In an effort to improve upon the traditional sepsis syndrome definitions, the predisposition, infection, response, organ dysfunction (PIRO) model was proposed to better characterize sepsis...
  52. doi Predictors of survival in sepsis: what is the best inflammatory marker to measure?
    Christoph Lichtenstern
    Department of Anesthesiology and Intensive Care Medicine, University Hospital of Giessen and Marburg, Giessen, Germany
    Curr Opin Infect Dis 25:328-36. 2012
    b>Sepsis is relevant due to its high morbidity and mortality. For both sepsis diagnosis and outcome prediction many biomarkers have been described in the literature...
  53. pmc Gut microbial colonisation in premature neonates predicts neonatal sepsis
    Juliette C Madan
    Department of Pediatrics, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03753, USA
    Arch Dis Child Fetal Neonatal Ed 97:F456-62. 2012
    Neonatal sepsis due to intestinal bacterial translocation is a major cause of morbidity and mortality...
  54. pmc Gut-origin sepsis: evolution of a concept
    Edwin A Deitch
    New Jersey Medical School, Newark, NJ, USA
    Surgeon 10:350-6. 2012
    The concept of bacterial translocation and gut-origin sepsis as a cause of systemic infectious complications and the multiple organ dysfunction syndrome (MODS) in surgical and ICU patients has emerged over the last several decades, ..
  55. pmc Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
    Song Hui Jia
    Department of Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    J Clin Invest 113:1318-27. 2004
    ..PBEF is also expressed in neutrophils from critically ill patients with sepsis in whom rates of apoptosis are profoundly delayed...
  56. doi Community-based treatment of serious bacterial infections in newborns and young infants: a randomized controlled trial assessing three antibiotic regimens
    Anita K M Zaidi
    Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Pediatr Infect Dis J 31:667-72. 2012
    b>Sepsis in the neonatal period is a major cause of child mortality in low-income countries. Hospitalization and parenteral penicillin/ampicillin and gentamicin therapy are recommended for management...
  57. doi Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007
    Tara Lagu
    Center for Quality of Care Research, Baystate Medical Center, Springfield, MA, USA
    Crit Care Med 40:754-61. 2012
    To assess trends in number of hospitalizations, outcomes, and costs of severe sepsis in the United States.
  58. ncbi Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
    Benjamin M P Tang
    Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia
    Lancet Infect Dis 7:210-7. 2007
    Procalcitonin is widely reported as a useful biochemical marker to differentiate sepsis from other non-infectious causes of systemic inflammatory response syndrome...
  59. doi Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?
    Lien Dejager
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, B9052 Ghent, Belgium
    Trends Microbiol 19:198-208. 2011
    b>Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory responses followed by immunosuppression. To study the pathophysiology of sepsis, diverse animal models have been developed...
  60. doi Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department
    David F Gaieski
    Department of Emergency Medicine, Division of Pulmonary, Allergy, and Critical Care, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 38:1045-53. 2010
    To study the association between time to antibiotic administration and survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department.
  61. ncbi Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 27:1230-51. 1999
    The purpose of this study was to determine whether apoptosis is a major mechanism of cell death in patients with sepsis. The activities of caspase-3 and the antiapoptotic protein, BCL-2, were investigated also.
  62. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department.
  63. pmc Long-term cognitive impairment and functional disability among survivors of severe sepsis
    Theodore J Iwashyna
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    JAMA 304:1787-94. 2010
    ..Although the incidence of severe sepsis is high and increasing, the magnitude of patients' long-term cognitive and functional limitations after sepsis is ..
  64. doi Long-term mortality and quality of life in sepsis: a systematic review
    Bradford D Winters
    Departments of Anesthesiology and Critical Care Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 38:1276-83. 2010
    Long-term outcomes from sepsis are poorly understood, and sepsis in patients may have different long-term effects on mortality and quality of life...
  65. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand...
  66. doi Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis
    E Gonzalez-Rey
    School of Medicine, University of Seville, Seville, Spain
    Gut 58:929-39. 2009
    ..This work investigates the therapeutic effects of human adipose-derived MSCs (hASCs) in various models of IBD and sepsis.
  67. pmc New approaches to sepsis: molecular diagnostics and biomarkers
    Konrad Reinhart
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Clin Microbiol Rev 25:609-34. 2012
    b>Sepsis is among the most common causes of death in hospitals. It arises from the host response to infection. Currently, diagnosis relies on nonspecific physiological criteria and culture-based pathogen detection...
  68. ncbi Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells
    Carmen Fiuza
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:2652-60. 2003
    Systemic inflammation because of sepsis results in endothelial cell activation and microvascular injury...
  69. doi Outcomes in severe sepsis and patients with septic shock: pathogen species and infection sites are not associated with mortality
    Jean Ralph Zahar
    Infection Control Unit, Necker University Hospital Paris, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care Med 39:1886-95. 2011
    We evaluated the respective influence of the causative pathogen and infection site on hospital mortality from severe sepsis related to community-, hospital-, and intensive care unit-acquired infections.
  70. pmc Role of innate host defenses in susceptibility to early-onset neonatal sepsis
    James L Wynn
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Duke University, 2424 Hock Plaza, Suite 504, DUMC Box 2739, Durham, NC 27710, USA
    Clin Perinatol 37:307-37. 2010
    Neonatal sepsis continues to take a devastating toll globally...
  71. doi The effect of statins on mortality from severe infections and sepsis: a systematic review and meta-analysis
    Surinder Janda
    University of British Columbia, Vancouver, British Columbia, Canada
    J Crit Care 25:656.e7-22. 2010
    The aim of this study was to systematically review the literature on the effect of statins on mortality in patients with infection and/or sepsis.
  72. doi Passive leg raising is predictive of fluid responsiveness in spontaneously breathing patients with severe sepsis or acute pancreatitis
    Sebastien Preau
    Service de Reanimation Polyvalente, Centre Hospitalier Jean Bernard, Valenciennes, France
    Crit Care Med 38:819-25. 2010
    ..We hypothesized that the hemodynamic response to passive leg raising indicates fluid responsiveness in nonintubated patients without mechanical ventilation...
  73. doi Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study
    Ricard Ferrer
    Critical Care Center, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Universidad Autonoma de Barcelona, Sabadell, Spain
    Am J Respir Crit Care Med 180:861-6. 2009
    Several Surviving Sepsis Campaign Guidelines recommendations are reevaluated.
  74. doi Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial
    Christian Meisel
    Department of Medical Immunology, Charite Campus Mitte, Berlin, Germany
    Am J Respir Crit Care Med 180:640-8. 2009
    Sustained sepsis-associated immunosuppression is associated with uncontrolled infection, multiple organ dysfunction, and death.
  75. pmc Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population
    Shevin T Jacob
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA
    PLoS ONE 4:e7782. 2009
    b>Sepsis likely contributes to the high burden of infectious disease morbidity and mortality in low income countries. Data regarding sepsis management in sub-Saharan Africa are limited...
  76. pmc Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
    Rungnapa Pankla
    Department of Clinical Immunology, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, 123 Mittraparp Road, Khon Kaen, 40002, Thailand
    Genome Biol 10:R127. 2009
    ..Septicemia is the most common presentation of the disease with a 40% mortality rate even with appropriate treatments. Better diagnostic tests are therefore needed to improve therapeutic efficacy and survival rates...
  77. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ..mimics vagus nerve stimulation, increases proinflammatory cytokine production and lethality from polymicrobial sepsis in splenectomized mice, indicating that the spleen is critical to the protective response of the cholinergic ..
  78. ncbi Seventy-five years of neonatal sepsis at Yale: 1928-2003
    Matthew J Bizzarro
    Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 116:595-602. 2005
    Yale-New Haven Hospital (Y-NHH) has maintained the longest running, single-center longitudinal database of neonatal sepsis, started in 1928...
  79. pmc Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, Lyon, France
    Mol Med 14:64-78. 2008
    ..It is now agreed that sepsis deeply perturbs immune homeostasis by inducing an initial tremendous systemic inflammatory response which is ..
  80. doi Bacterial sensing, cell signaling, and modulation of the immune response during sepsis
    Reinaldo Salomao
    Division of Infectious Diseases, Department of Medicine, Hospital Sao Paulo, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Shock 38:227-42. 2012
    Since the definition of systemic inflammatory response syndrome/sepsis was originally proposed, a large amount of new information has been generated showing a much more complex scenario of inflammatory and counterinflammatory responses ..
  81. doi Nationwide trends of severe sepsis in the 21st century (2000-2007)
    Gagan Kumar
    Department of Medicine, Division of Pulmonary and Critical Care, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Chest 140:1223-31. 2011
    Severe sepsis is common and often fatal. The expanding armamentarium of evidence-based therapies has improved the outcomes of persons with this disease...
  82. doi Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis
    Braedon McDonald
    Calvin, Phoebe, and Joan Snyder Institute for Chronic Disease, Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada
    Cell Host Microbe 12:324-33. 2012
    During the systemic inflammatory response of severe sepsis, neutrophils accumulate in the liver microcirculation, but their functional significance is largely unknown...
  83. doi Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials
    Petros Kopterides
    Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
    Crit Care Med 38:2229-41. 2010
    ..We sought to determine the effectiveness and safety of procalcitonin-guided algorithms in the management of septic patients in the intensive care unit...
  84. pmc Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis
    Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    BMJ 346:f839. 2013
    To assess the effects of fluid therapy with hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin on mortality, kidney injury, bleeding, and serious adverse events in patients with sepsis.
  85. doi Early biomarker activity in severe sepsis and septic shock and a contemporary review of immunotherapy trials: not a time to give up, but to give it earlier
    Emanuel P Rivers
    Department of Emergency Medicine and Surgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Shock 39:127-37. 2013
    ..This insight may partly explain the futility of time-insensitive immunotherapy trials for severe sepsis and septic shock...
  86. doi Elevated plasma matrix metalloproteinases and their tissue inhibitors in patients with severe sepsis
    Payam Yazdan-Ashoori
    Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Crit Care 26:556-65. 2011
    ..1) the concentrations of MMPs and their tissue inhibitors (TIMPs) in plasma obtained from patients with severe sepsis, (2) to correlate changes in MMP and TIMP levels with disease severity, and (3) to investigate recombinant ..
  87. pmc Biomarkers of sepsis
    James D Faix
    Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Crit Rev Clin Lab Sci 50:23-36. 2013
    b>Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury...
  88. ncbi Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Ann Emerg Med 49:88-98, 98.e1-2. 2007
    To study early microcirculatory perfusion indices in patients with severe sepsis/septic shock, compare early microcirculatory indices in sepsis survivors versus nonsurvivors, and identify systemic hemodynamic/oxygen transport variables ..
  89. ncbi Sepsis and the heart
    M W Merx
    Department of Medicine, RWTH Aachen University, Aachen, Germany
    Circulation 116:793-802. 2007
    b>Sepsis is generally viewed as a disease aggravated by an inappropriate immune response encountered in the afflicted individual...
  90. pmc Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 461:1287-91. 2009
    ..In mice with microbial sepsis initiated by caecal ligation and puncture, RvD2 sharply decreased both local and systemic bacterial burden, ..
  91. ncbi Neutrophils in development of multiple organ failure in sepsis
    K A Brown
    Division of Medical Education, King s College School of Medicine, London, UK
    Lancet 368:157-69. 2006
    Multiple organ failure is a major threat to the survival of patients with sepsis and systemic inflammation. In the UK and in the USA, mortality rates are currently comparable with and projected to exceed those from myocardial infarction...
  92. pmc The burden of invasive early-onset neonatal sepsis in the United States, 2005-2008
    Emily J Weston
    Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 30:937-41. 2011
    b>Sepsis in the first 3 days of life is a leading cause of morbidity and mortality among infants...
  93. pmc Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis
    Seth W Glickman
    Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Acad Emerg Med 17:383-90. 2010
    ..To enhance the ability to intervene in patients with lesser illness severity, a better understanding of the natural history of the early progression from simple infection to more severe illness is needed...
  94. doi Peritoneal negative pressure therapy prevents multiple organ injury in a chronic porcine sepsis and ischemia/reperfusion model
    Brian D Kubiak
    Department of Surgery, Upstate University Hospital, Syracuse, New York 13210, USA
    Shock 34:525-34. 2010
    b>Sepsis and hemorrhage can result in injury to multiple organs and is associated with an extremely high rate of mortality. We hypothesized that peritoneal negative pressure therapy (NPT) would reduce systemic inflammation and organ damage...
  95. pmc The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*
    Shevin T Jacob
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA
    Crit Care Med 40:2050-8. 2012
    In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers.
  96. pmc Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 306:1574-81. 2011
    ....
  97. pmc Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis
    Konstantinos Kambas
    First Department of Internal Medicine, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    PLoS ONE 7:e45427. 2012
    b>Sepsis is associated with systemic inflammatory responses and induction of coagulation system...
  98. doi Oxidative stress and mitochondrial dysfunction in sepsis
    H F Galley
    Academic Unit of Anaesthesia and Intensive Care, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK
    Br J Anaesth 107:57-64. 2011
    b>Sepsis-related organ dysfunction remains the most common cause of death in the intensive care unit (ICU), despite advances in healthcare and science...
  99. doi The economics of sepsis
    Andrew N Chalupka
    Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    Crit Care Clin 28:57-76, vi. 2012
    b>Sepsis, severe sepsis, and septic shock impose a growing economic burden on health care systems globally. This article first describes the epidemiology of sepsis within the United States and internationally...
  100. pmc Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis
    Pascal M Lavoie
    Child and Family Research Institute, Vancouver, British Columbia, Canada
    J Infect Dis 202:1754-63. 2010
    ..Infants born prematurely are highly vulnerable to infections and also exhibit a high susceptibility to organ damage due to inflammation...
  101. doi Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis
    Daniel R Ricciuto
    McLaughlin Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, The University of Toronto, Ontario, Canada
    Crit Care Med 39:702-10. 2011
    To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel biomarkers of morbidity and mortality in patients with severe sepsis.

Research Grants72

  1. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..nitric oxide (NO) and superoxide anion are generally accepted to contribute to widespread tissue injury in sepsis via their induction of microvacular ischemia and direct organ toxicity...
  2. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..severe forms of the disease characterized by full-thickness necrosis of the intestine, followed by rupture and sepsis. Ninety percent of NEC cases occur in infants born before 36 weeks'gestational age, occurring in up to 10% of ..
  3. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..The basis of this proposal is to establish whether Cryab is effective in models of LPS toxemia and bacterial sepsis. The aims of the grant are first to demonstrate that Cryab, and not Cryab with a point mutation at residue 120, ..
  4. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..As such, MF subtypes play a central role in regulating the pathogenesis and expression of diseases as diverse as sepsis, atherosclerosis and asthma...
  5. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..respiratory failure, arising after clinical events including major surgery, trauma, multiple transfusions and sepsis. ALI/ARDS have an associated mortality of 40-80% and current pharmacological modalities have been unsuccessful in ..
  6. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..The most common NI sites were sepsis and NEC...
  7. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..The investigations will employ experimental models of endotoxemia and sepsis utilizing mouse strains that carry genetically silenced forms of these X-linked proteins...
  8. Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1
    RAJESH K ANEJA; Fiscal Year: 2013
    ..HMGB1 is a crucial late-acting mediator of sepsis in patients with sepsis, severe sepsis and septic shock...
  9. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..ER suppression of NFB is critical for protective effects of estrogens in inflammatory bowel disease, sepsis, arthritis, atherosclerosis, and lipid metabolism, highlighting the broad importance of this pathway...
  10. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..In some cases PDT can save mice from a certain death due to sepsis that develops from an untreated localized infection...
  11. Citrulline to Prevent or Mitigate Acute Lung Injury in Severe Sepsis
    Todd W Rice; Fiscal Year: 2013
    ..to investigate the role of citrulline in preventing or mitigatin acute lung injury (ALI) in patients with severe sepsis. The urea/NO cycle plays an integral role in severe sepsis pathophysiology, a disease with high morbidity and ..
  12. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
    ..striated muscle and other aerobic tissues from inhibition of mitochondrial respiration during inflammation, sepsis, and nitric oxide inhalation...
  13. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sepsis is a disease process representing the systemic response to severe infection...
  14. Respiration in Sepsis
    Claude A Piantadosi; Fiscal Year: 2013
    ..aureus sepsis. The need for basic research in this area is high due to the high prevalence and cost of sepsis-induced multiple ..
  15. Role of Vimentin in Pathogenesis of CNS Inflammation
    Sheng He Huang; Fiscal Year: 2013
    ..Vimentin (Vim), in conjunction with its co-receptor PSF, plays an important role in the pathogenesis of neonatal sepsis and meningitis (NSM), which remains a major cause of death in newborns, especially in low-birth weight infants...
  16. Regulation of IFN-beta induction by P2X7 purinergic receptor signaling
    JUDITH ANNE SMITH; Fiscal Year: 2011
    ..As both IFN- [unreadable] and purinergic receptor signaling have been implicated in bacterial sepsis and bone morphogenesis, it is critical to understand the mechanism of how P2X7 modulates the induction of IFN- [..
  17. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy R Billiar; Fiscal Year: 2013
    ..could lead to effective approaches to limit not only the early organ damage but also the susceptibility to late sepsis and multiple organ failure (MOF)...
  18. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
    ..properties, improving survival and reducing the production of proin- flammatory cytokines in animal models of sepsis. It is possible that inhibition of T3 and T4 bioactivity, by PBDEs increases the risk of pretem birth by favoring ..
  19. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..recovery focusing on innate immune responsiveness (immunoparalysis), Interleukin 8 (a predictor of outcome for sepsis and acute lung injury), Vitamin D, and SP-A and SP-D (important for lung function and viral immunity), and 3...
  20. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..and mode of delivery;and 3) postnatal factors such as intraventricular hemorrhage, nosocomial infections and sepsis, days on mechanical ventilation, necrotizing enterocolitis and chronic lung disease...
  21. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..antimicrobial agents, improved supportive care, and the introduction of an FDA approved adjunctive therapy for sepsis, (Xigris(r), drotrecogin alfa), the mortality rate for severe sepsis and septic shock of 30-60% remains high...
  22. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..These diseases would include not only bacterial sepsis, but diseases such as rheumatoid arthritis, diabetes, stroke, CNS cancers, and even obesity and Alzheimer's ..
  23. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..Pathogenesis of endotoxic shock/sepsis has not been understood in great detail, moreover its therapy, including antibiotics, remains largely symptomatic ..
  24. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Group B streptococcus (GBS) is currently a leading single cause of neonatal sepsis and the third most frequent over all cause of bacterial meningitis in the United States...
  25. Human Heme Oxygenase-1 Gene Regulation in Renal Injury
    Anupam Agarwal; Fiscal Year: 2012
    ..These studies will also be applicable to other disease settings such as atherosclerosis, sepsis and transplant rejection wherein HO-1 plays an important protective role...
  26. Pathogenic Mechanisms of PBEF in Ventilator Induced Lung Injury
    Joe G N Garcia; Fiscal Year: 2012
    ..pre-B cell colony enhancing factor (PBEF) as a novel ALI susceptibility candidate gene and novel biomarker in sepsis and ALI...
  27. The Role of Sex in Self Antigen Generation in SLE
    David Stephen Pisetsky; Fiscal Year: 2010
    ..Studies on the effects of sex influence on conditions such as shock and sepsis suggest, however, that estrogens may modulate macrophage function and thereby influence the clearance process...
  28. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..SIRS is a clinical expression of the action of complex acute-phase intrinsic mediators that precedes sepsis and subsequent tissue damage leading to Multiple Organ Failure...
  29. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..a wide spectrum of infectious diseases spanning from rather minor skin infections to serious conditions such as sepsis, pneumonia and endocarditis...
  30. Developing a New Antioxidant Activator to Intervene in Lung Inflammatory Diseases
    JOHN WILLIMANN; Fiscal Year: 2009
    ..include allergic asthma, chronic obstructive pulmonary disease, viral and bacterial infections, and related sepsis-induced acute lung injury...
  31. Research Career Development in Child Health
    Michael W Konstan; Fiscal Year: 2012
    ..childhood diseases, including lung disease associated with prematurity, cystic fibrosis, asthma, pneumonia, sepsis, cancer, coagulation disorders, bone marrow transplantation, diabetes, obesity and cardiovascular disease, ..
  32. Regulation of Innate Immunity by the Sympathetic Nervous System Druing Sepsis
    Eric J Seeley; Fiscal Year: 2013
    ..provided by applicant): When bacteria evade host defenses and enter the blood stream, the clinical syndrome of sepsis ensues...
  33. HMG in Post Operative and Traumatic Stress
    Kevin J Tracey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Severe sepsis, a clinical syndrome in patients with infection, surgery, trauma, or other injury, is associated with high mortality and limited effective therapeutics...
  34. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..The results are likely to be beneficial for not only patients with scleroderma, but also patients with asthma, sepsis, and tuberculosis, in all of which IL-442 has been suggested to play a significant role.
  35. Heme Oxygenase Enzymes/Carbon Monoxide in Hepatic Dysfunction from hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..Mortality in patients that survive the initial insult is often due to the development of organ dysfunction and/or sepsis. Thus, understanding the cellular mechanisms that lead to tissue injury and the development of therapeutic ..
  36. Complement Activation on Neisseria meningitidis
    Sanjay Ram; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Meningococcal meningitis and sepsis is a major health problem worldwide...
  37. Identification of vaccine antigens based on expression in blood
    PETER TRIP BEERNINK; Fiscal Year: 2011
    ..our hypothesis, we will use Neisseria meningitidis group B (NmB), an important cause of bacterial meningitis and sepsis, for which there is no broadly protective vaccine available...
  38. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants...
  39. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..e., decreased T cell and macrophage (MO) antigen presentation function and increased lethality from subsequent sepsis, in young males;but not in proestrus females following trauma-hemorrhage (T-H)...
  40. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..pregnancy, GBS can cause urinary tract infections, chorioamnionitis, postpartum wound infection, pyelonephritis, sepsis, and rarely meningitis...
  41. The Organ Specific Role of Superoxide Dismutase in Sepsis
    Alix Ashare; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Severe sepsis results in significant morbidity and mortality. Treatment options are limited and potentially unsuccessful...
  42. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
    ..revised application to study the regulation and the role of mitochondrial biogenesis and mitophagy in experimental sepsis and acute lung injury (ALI) caused by S. aureus...
  43. C/EBP, atrogin-1, and muscle wasting
    Per Olof Hasselgren; Fiscal Year: 2009
    ABSTRACT A number of catabolic disease states, including sepsis, severe injury, and cancer, are characterized by muscle wasting, mainly reflecting increased breakdown of myofibrillar (contractile) proteins...
  44. Translational Immunology Research and Accelerated [vaccine] Development (TRIAD)
    ANNE SEARLS DEGROOT; Fiscal Year: 2013
    ..of meloidosis, is responsible for an estimated 20% of septicemias and approximately 40% of deaths due to bacterial sepsis in tropical regions of the world...
  45. Decompressive craniotomy versus medical therapy for refractory intracranial hyper
    Raminder Nirula; Fiscal Year: 2010
    ..Comparative Effectiveness Research and specific Challenge Topic, 05-GM-101: Anesthesiology Clinical Pharmacology Sepsis Trauma, Burn, and Peri-operative Injury Wound Healing...
  46. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    ..Mounting evidence suggests, however, that in addition to ammonia, cytokines and related sepsis and inflammation also contribute to the brain edema in ALF...
  47. Lipid A &Innate Immune Receptors in Neisseria Infection
    Gary A Jarvis; Fiscal Year: 2013
    ..have important consequences during Neisserial infections, leading to exaggerated responses such as meningococcal sepsis and gonococcal pelvic inflammatory disease...
  48. ClC-3 ion transport modulates NADPH oxidase-dependent PMN priming by endotoxin
    Jessica G Moreland; Fiscal Year: 2012
    The mortality from Gram-negative sepsis arises from development of the sepsis syndrome with uncontrolled systemic inflammation...
  49. Prophage-associated virulence factors in pathogenic Neisseria species
    ANNA KARLS; Fiscal Year: 2009
    ..Thus, the MDA prophage Zot proteins in GC and MC have the potential to be involved in inflammation, sepsis, and/or invasion of the blood-brain barrier...
  50. Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants
    Leslie A Parker; Fiscal Year: 2013
    ..liver disease (PNALD), poor growth, more hours requiring a central venous line (CVL), increased risk of late onset sepsis (LOS), prolonged hospitalization, as well as disturbances in gastrointestinal (GI) integrity and function...
  51. Checkpoints of TNF Gene Regulation
    Anne Goldfeld; Fiscal Year: 2013
    ..disease, diabetes, eczema, lupus, several different forms of cancer, and multiple infectious diseases including sepsis, tuberculosis (TB), and HIV-1...
  52. HLA class II transgenic mouse models for S. aureus infections and superantigens
    Govindarajan Rajagopalan; Fiscal Year: 2013
    ..of diseases;from benign, localized skin infections to life-threatening, systemic illnesses including pneumonia, sepsis and menstrual or non-menstrual toxic shock syndromes (TSS). The virulence and pathogenicity of S...
  53. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite recent advance in antibiotic therapy and intensive care, sepsis remains the most common cause of death in the intensive care unit, claiming >225,000 victims annually in the U.S. alone...
  54. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
    ..those severely injured trauma patient with systemic inflammatory response syndrome (SIRS) who will develop the sepsis pathology...
  55. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..septic arthritis, osteomyelitis, bacteremia, pneumonia, abscesses of various organs, meningitis, endocarditis, and sepsis. Despite advances in conventional antibiotic therapy, the incidence of S...
  56. L-carnitine Treatment for Vasopressor Dependent Septic Shock
    Alan E Jones; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): More humans die in the intensive care unit from sepsis than from any other cause. Death from sepsis is the culmination of widespread hypoperfusion, cellular hypoxia, and multiple organ failure...
  57. Sepsis Outcomes and Aging: Role of Sleep Disruption and the Blood Brain Barrier
    Mark R Opp; Fiscal Year: 2013
    ..b>Sepsis annually kills hundreds of thousands of people in the US with associated hospital costs of billions of dollars...
  58. Regulation of Neutrophilic Lung Inflammation
    John W Christman; Fiscal Year: 2013
    Abstract: The acute respiratory distress syndrome (ARDS) associated with severe sepsis is a neutrophilic inflammatory lung disease (NLI) with excessive morbidity and mortality...
  59. Molecular mechanism of apolipoprotein binding to lipopolysaccharides
    PAUL MICHIEL WEERS; Fiscal Year: 2013
    ..This knowledge can be used to improve treatment and develop new strategies to treat Gram-negative sepsis. PUBLIC HEALTH RELEVANCE: Bacterial sepsis is a common threat causing more than 200,000 fatalities each year in ..
  60. Mechanisms of Pseudomonas Resistance to Membrane Permeabilization by SP-A
    Gee W Lau; Fiscal Year: 2012
    ..of nosocomial infections in humans, lung infections in cystic fibrosis patients, and a primary cause of death and sepsis in immuno-compromised individuals. The continuous emergence of antibiotic resistant P...
  61. Role of Staphylococcus aureus alpha-hemolysin in disease
    Juliane Bubeck Wardenburg; Fiscal Year: 2013
    ..pathogenesis of pneumonia, skin and corneal infection, central nervous system infection, toxic shock syndrome and sepsis. The primary goal of this application is to develop a refined view of how Hla injures cells and epithelial tissues,..
  62. Regulation of Endothelial ICAM-1 and PMN-Mediated Lung Injury by Actin Dynamics
    Fabeha Fazal; Fiscal Year: 2013
    ..studies is to address the mechanisms by which thrombin, a serine protease released during clotting initiated by sepsis or vascular injury, regulates the expression of adhesive protein intercellular adhesion molecule-1 (ICAM-1;CD54) ..
  63. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    Despite advances in the treatment of patients with sepsis, sepsis remains the second most common cause of death in non-coronary intensive care units and the tenth leading cause of death overall in high-income countries...
  64. PRIMATE MODEL AND PATHOGENESIS OF ANTHRAX SEPSIS
    Shinichiro Kurosawa; Fiscal Year: 2009
    ..coli-mediated sepsis. Activated protein C (APC), a member of the protein C pathway, is an important regulator of this host coagulation ..
  65. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..and cytokines mediators, circulating factors produced by the innate immune system, as critical mediators of sepsis-related tissue injury and death...
  66. Critical Care Excellence in Sepsis and Trauma (CREST)
    DEE WALKER contact FORD; Fiscal Year: 2010
    ..A quasi-experimental clinical trial will test the effectiveness of the Critical Care Excellence in Sepsis and Trauma Program (CREST)...
  67. CONTRIBUTION OF LPS TO EXP ENTEROCOCCAL SEPSIS
    Christopher Papasian; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Severe sepsis and septic shock secondary to Gram-positive bacterial pathogen infection is increasingly recognized in a recent series of patients with sepsis from the USA and other ..
  68. Protocolized Care for Early Septic Shock (ProCESS)
    Derek C Angus; Fiscal Year: 2012
    PROVIDED. Severe sepsis is the syndrome of acute organ dysfunction secondary to infection. It affects 750,000 Americans each year, with a mortality of 30%...
  69. Adrenergic Control of Stem Cell Lineage Commitment in Sepsis
    KUZHALI MUTHUMALAIAPPAN; Fiscal Year: 2009
    ..Central to the patho-physiology of burn sepsis is the sequential change in macrophage cytokine signals (hyper response to hypo response) in the periphery and in ..
  70. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2007
    Critical injury and sepsis continues to be a major health concern in the US. Many of these patients succumb to infections that lead to unabated systemic inflammatory response and multiple organ failure...
  71. Extracorporeal Blood Purification For Sepsis Therapy
    Susan Szathmary; Fiscal Year: 2006
    ..constituents can result in an overwhelming systemic inflammatory response and procoagulant state leading to sepsis, septic shock and death...
  72. Radiation Combined Injury: Mechanisms and Therapeutic Approaches
    Ping Wang; Fiscal Year: 2009
    ..radiation exposure scenario, radiation victims likely suffer from additional injuries such as infection and sepsis. Despite advances in our understanding of radiation injury or advances in the management of sepsis patients, ..