sepsis

Summary

Summary: The presence of pathogenic microorganisms or their toxins in tissues or in the blood. Systemic disease caused by the spread of the microorganisms via the circulating blood is commonly called SEPTICEMIA. (From Stedman, 25th ed)

Top Publications

  1. pmc Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection
    Charalambos Gogos
    1st Department of Internal Medicine, University of Patras, Medical School, 26504 Rio, Greece
    Crit Care 14:R96. 2010
  2. ncbi Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release
    Keliang Xie
    Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin, P R China
    Shock 34:90-7. 2010
  3. pmc Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis
    Ephraim L Tsalik
    Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
    J Clin Microbiol 48:26-33. 2010
  4. pmc MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis
    Catalin Vasilescu
    Department of Surgery, Fundeni Clinical Hospital, Bucharest, Romania
    PLoS ONE 4:e7405. 2009
  5. ncbi Statins for the prevention and treatment of infections: a systematic review and meta-analysis
    Imad M Tleyjeh
    Department of Medicine, King Fahd Medical City, Riyadh, Saudi Arabia
    Arch Intern Med 169:1658-67. 2009
  6. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
  7. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
  8. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
  9. ncbi The immunopathogenesis of sepsis
    Jonathan Cohen
    Brighton and Sussex Medical School, Westlain House, Falmer, UK
    Nature 420:885-91. 2002
  10. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003

Detail Information

Publications347 found, 100 shown here

  1. pmc Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection
    Charalambos Gogos
    1st Department of Internal Medicine, University of Patras, Medical School, 26504 Rio, Greece
    Crit Care 14:R96. 2010
    Although major changes of the immune system have been described in sepsis, it has never been studied whether these may differ in relation to the type of underlying infection or not. This was studied for the first time.
  2. ncbi Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release
    Keliang Xie
    Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin, P R China
    Shock 34:90-7. 2010
    Despite recent advances in antibiotic therapy and intensive care, sepsis is still considered to be the most common cause of death in intensive care units...
  3. pmc Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis
    Ephraim L Tsalik
    Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
    J Clin Microbiol 48:26-33. 2010
    b>Sepsis is caused by a heterogeneous group of infectious etiologies. Early diagnosis and the provision of appropriate antimicrobial therapy correlate with positive clinical outcomes...
  4. pmc MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis
    Catalin Vasilescu
    Department of Surgery, Fundeni Clinical Hospital, Bucharest, Romania
    PLoS ONE 4:e7405. 2009
    The physiopathology of sepsis continues to be poorly understood, and despite recent advances in its management, sepsis is still a life-threatening condition with a poor outcome...
  5. ncbi Statins for the prevention and treatment of infections: a systematic review and meta-analysis
    Imad M Tleyjeh
    Department of Medicine, King Fahd Medical City, Riyadh, Saudi Arabia
    Arch Intern Med 169:1658-67. 2009
    ..Our objective was to examine the association between statin use and the risk of infections and related outcomes...
  6. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004.
  7. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    To determine the incidence, cost, and outcome of severe sepsis in the United States.
  8. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand...
  9. ncbi The immunopathogenesis of sepsis
    Jonathan Cohen
    Brighton and Sussex Medical School, Westlain House, Falmer, UK
    Nature 420:885-91. 2002
    b>Sepsis is a condition that results from a harmful or damaging host response to infection...
  10. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
    ..response to infection, which is a progressive injurious process that falls under the generalized term 'sepsis' and includes sepsis-associated organ dysfunction as well...
  11. ncbi CDC definitions for nosocomial infections, 1988
    J S Garner
    Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia
    Am J Infect Control 16:128-40. 1988
    ..Other hospitals may wish to adopt or modify them for use in their nosocomial infections surveillance programs...
  12. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
    b>Sepsis represents a substantial health care burden, and there is limited epidemiologic information about the demography of sepsis or about the temporal changes in its incidence and outcome...
  13. pmc Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    Krisztian Nemeth
    National Institute of Dental and Craniofacial Research NIDCR, Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, MD 20892, USA
    Nat Med 15:42-9. 2009
    b>Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed...
  14. ncbi Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
    Stephen R Clark
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Nat Med 13:463-9. 2007
    It has been known for many years that neutrophils and platelets participate in the pathogenesis of severe sepsis, but the inter-relationship between these players is completely unknown...
  15. pmc Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
    Intensive Care Med 34:17-60. 2008
    To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004.
  16. pmc Harmful molecular mechanisms in sepsis
    Daniel Rittirsch
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109 0602, USA
    Nat Rev Immunol 8:776-87. 2008
    b>Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and clinicians and are a tremendous burden for health-care systems...
  17. ncbi International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics
    Brahm Goldstein
    FCCM Oregon Health and Science University, Portland, OR, USA
    Pediatr Crit Care Med 6:2-8. 2005
    Although general definitions of the sepsis continuum have been published for adults, no such work has been done for the pediatric population...
  18. ncbi The pathophysiology and treatment of sepsis
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 348:138-50. 2003
  19. pmc Sepsis biomarkers: a review
    Charalampos Pierrakos
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 14:R15. 2010
    Biomarkers can be useful for identifying or ruling out sepsis, identifying patients who may benefit from specific therapies or assessing the response to therapy.
  20. ncbi Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    JAMA 292:2357-65. 2004
    ..Neonatal infections are frequent complications of extremely low-birth-weight (ELBW) infants receiving intensive care...
  21. doi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
    Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis.
  22. pmc Immunosuppression in patients who die of sepsis and multiple organ failure
    Jonathan S Boomer
    Department of Medicine, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    JAMA 306:2594-605. 2011
    Severe sepsis is typically characterized by initial cytokine-mediated hyperinflammation. Whether this hyperinflammatory phase is followed by immunosuppression is controversial...
  23. ncbi The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
    Mitchell M Levy
    Division of Pulmonary, Sleep and Critical Care Medicine Care Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 38:367-74. 2010
    The Surviving Sepsis Campaign (SSC or "the Campaign") developed guidelines for management of severe sepsis and septic shock...
  24. pmc Extracellular histones are major mediators of death in sepsis
    Jun Xu
    Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Nat Med 15:1318-21. 2009
    Hyperinflammatory responses can lead to a variety of diseases, including sepsis. We now report that extracellular histones released in response to inflammatory challenge contribute to endothelial dysfunction, organ failure and death ..
  25. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  26. doi The endothelium: physiological functions and role in microcirculatory failure during severe sepsis
    H Ait-Oufella
    INSERM U970, PAris Research Cardiovascular Center, Paris, France
    Intensive Care Med 36:1286-98. 2010
    ..During severe sepsis, the endothelium becomes proadhesive, procoagulant, antifibrinolytic and is characterized by alterations of ..
  27. pmc The pathogenesis of sepsis
    Deborah J Stearns-Kurosawa
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Massachusetts 02218, USA
    Annu Rev Pathol 6:19-48. 2011
    b>Sepsis is a serious clinical condition that represents a patient's response to a severe infection and has a very high mortality rate...
  28. ncbi SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis
    Padmam Puneet
    Department of Physiology, National University of Singapore, 117597 Singapore
    Science 328:1290-4. 2010
    During sepsis, activation of phagocytes leads to the overproduction of proinflammatory cytokines, causing systemic inflammation...
  29. ncbi Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatrics 110:285-91. 2002
    Late-onset sepsis (occurring after 3 days of age) is an important problem in very low birth weight (VLBW) infants...
  30. doi Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis
    Steve Lancel
    Department of Physiology, Institut de Médecine Prédictive et de Recherche Thérapeutique Institut Fédératif de Recherche, Universite de Lille 2, Faculte de Medecine, Lille, France
    J Pharmacol Exp Ther 329:641-8. 2009
    ..capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects...
  31. pmc The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
    Mitchell M Levy
    Division of Pulmonary, Sleep and Critical Care Medicine, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Intensive Care Med 36:222-31. 2010
    The Surviving Sepsis Campaign (SSC or "the Campaign") developed guidelines for management of severe sepsis and septic shock...
  32. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
    To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units.
  33. doi Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department
    David F Gaieski
    Department of Emergency Medicine, Division of Pulmonary, Allergy, and Critical Care, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 38:1045-53. 2010
    To study the association between time to antibiotic administration and survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department.
  34. doi Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?
    Lien Dejager
    Department for Molecular Biomedical Research, Flanders Institute for Biotechnology VIB, B9052 Ghent, Belgium
    Trends Microbiol 19:198-208. 2011
    b>Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory responses followed by immunosuppression. To study the pathophysiology of sepsis, diverse animal models have been developed...
  35. ncbi Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options
    C A Gogos
    Department of Medicine, Section of Infectious Diseases, Patras University Medical School, Patras, Greece
    J Infect Dis 181:176-80. 2000
    ..and IL-1 receptor antagonists (IL-1ra) and soluble TNF receptors (sTNFRs) were measured in 65 patients with severe sepsis. All patients were evaluated clinically and microbiologically and were followed up for clinical outcome...
  36. doi Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis
    E Gonzalez-Rey
    School of Medicine, University of Seville, Seville, Spain
    Gut 58:929-39. 2009
    ..This work investigates the therapeutic effects of human adipose-derived MSCs (hASCs) in various models of IBD and sepsis.
  37. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department.
  38. pmc Role of innate host defenses in susceptibility to early-onset neonatal sepsis
    James L Wynn
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Duke University, 2424 Hock Plaza, Suite 504, DUMC Box 2739, Durham, NC 27710, USA
    Clin Perinatol 37:307-37. 2010
    Neonatal sepsis continues to take a devastating toll globally...
  39. pmc Immunodesign of experimental sepsis by cecal ligation and puncture
    Daniel Rittirsch
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109, USA
    Nat Protoc 4:31-6. 2009
    b>Sepsis remains a prevalent clinical challenge and the underlying pathophysiology is still poorly understood...
  40. ncbi Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study
    Ricard Ferrer
    Critical Care Center, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Universidad Autonoma de Barcelona, Sabadell, Spain
    Am J Respir Crit Care Med 180:861-6. 2009
    Several Surviving Sepsis Campaign Guidelines recommendations are reevaluated.
  41. doi Passive leg raising is predictive of fluid responsiveness in spontaneously breathing patients with severe sepsis or acute pancreatitis
    Sebastien Preau
    Service de Reanimation Polyvalente, Centre Hospitalier Jean Bernard, Valenciennes, France
    Crit Care Med 38:819-25. 2010
    ..We hypothesized that the hemodynamic response to passive leg raising indicates fluid responsiveness in nonintubated patients without mechanical ventilation...
  42. doi The effect of statins on mortality from severe infections and sepsis: a systematic review and meta-analysis
    Surinder Janda
    University of British Columbia, Vancouver, British Columbia, Canada
    J Crit Care 25:656.e7-22. 2010
    The aim of this study was to systematically review the literature on the effect of statins on mortality in patients with infection and/or sepsis.
  43. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ..mimics vagus nerve stimulation, increases proinflammatory cytokine production and lethality from polymicrobial sepsis in splenectomized mice, indicating that the spleen is critical to the protective response of the cholinergic ..
  44. pmc Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
    Rungnapa Pankla
    Department of Clinical Immunology, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, 123 Mittraparp Road, Khon Kaen, 40002, Thailand
    Genome Biol 10:R127. 2009
    ..Septicemia is the most common presentation of the disease with a 40% mortality rate even with appropriate treatments. Better diagnostic tests are therefore needed to improve therapeutic efficacy and survival rates...
  45. pmc Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population
    Shevin T Jacob
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA
    PLoS ONE 4:e7782. 2009
    b>Sepsis likely contributes to the high burden of infectious disease morbidity and mortality in low income countries. Data regarding sepsis management in sub-Saharan Africa are limited...
  46. pmc Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, Lyon, France
    Mol Med 14:64-78. 2008
    ..It is now agreed that sepsis deeply perturbs immune homeostasis by inducing an initial tremendous systemic inflammatory response which is ..
  47. ncbi Seventy-five years of neonatal sepsis at Yale: 1928-2003
    Matthew J Bizzarro
    Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 116:595-602. 2005
    Yale-New Haven Hospital (Y-NHH) has maintained the longest running, single-center longitudinal database of neonatal sepsis, started in 1928...
  48. doi Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials
    Petros Kopterides
    Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
    Crit Care Med 38:2229-41. 2010
    ..We sought to determine the effectiveness and safety of procalcitonin-guided algorithms in the management of septic patients in the intensive care unit...
  49. doi The economics of sepsis
    Andrew N Chalupka
    Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    Crit Care Clin 28:57-76, vi. 2012
    b>Sepsis, severe sepsis, and septic shock impose a growing economic burden on health care systems globally. This article first describes the epidemiology of sepsis within the United States and internationally...
  50. doi Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis
    Daniel R Ricciuto
    McLaughlin Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, The University of Toronto, Ontario, Canada
    Crit Care Med 39:702-10. 2011
    To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel biomarkers of morbidity and mortality in patients with severe sepsis.
  51. doi Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response
    Thierry Gustot
    Department of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Belgium
    Curr Opin Crit Care 17:153-9. 2011
    ..To describe the pathogenesis and emphasize prognosis of systemic inflammatory response during severe infection...
  52. ncbi Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Ann Emerg Med 49:88-98, 98.e1-2. 2007
    To study early microcirculatory perfusion indices in patients with severe sepsis/septic shock, compare early microcirculatory indices in sepsis survivors versus nonsurvivors, and identify systemic hemodynamic/oxygen transport variables ..
  53. doi Oxidative stress and mitochondrial dysfunction in sepsis
    H F Galley
    Academic Unit of Anaesthesia and Intensive Care, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK
    Br J Anaesth 107:57-64. 2011
    b>Sepsis-related organ dysfunction remains the most common cause of death in the intensive care unit (ICU), despite advances in healthcare and science...
  54. pmc Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 461:1287-91. 2009
    ..In mice with microbial sepsis initiated by caecal ligation and puncture, RvD2 sharply decreased both local and systemic bacterial burden, ..
  55. pmc Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 306:1574-81. 2011
    ....
  56. pmc The burden of invasive early-onset neonatal sepsis in the United States, 2005-2008
    Emily J Weston
    Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 30:937-41. 2011
    b>Sepsis in the first 3 days of life is a leading cause of morbidity and mortality among infants...
  57. doi Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis
    Karel Tyml
    Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada
    Microcirculation 18:152-62. 2011
    b>Sepsis is a complex multifaceted response to a local infectious insult. One important facet is the circulatory system dysfunction, which includes capillary bed plugging...
  58. doi Proof of principle: the predisposition, infection, response, organ failure sepsis staging system
    Michael D Howell
    Pulmonary and Critical Care Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Crit Care Med 39:322-7. 2011
    In an effort to improve upon the traditional sepsis syndrome definitions, the predisposition, infection, response, organ dysfunction (PIRO) model was proposed to better characterize sepsis...
  59. doi Molecular biology of inflammation and sepsis: a primer
    Ismail Cinel
    Division of Critical Care Medicine, The Robert Wood Johnson School of Medicine, The University of Medicine and Dentistry of New Jersey, Camden, NJ, USA
    Crit Care Med 37:291-304. 2009
    Remarkable progress has been made during the last decade in defining the molecular mechanisms that underlie septic shock. This rapidly expanding field is leading to new therapeutic opportunities in the management of severe sepsis.
  60. doi Peritoneal negative pressure therapy prevents multiple organ injury in a chronic porcine sepsis and ischemia/reperfusion model
    Brian D Kubiak
    Department of Surgery, Upstate University Hospital, Syracuse, New York 13210, USA
    Shock 34:525-34. 2010
    b>Sepsis and hemorrhage can result in injury to multiple organs and is associated with an extremely high rate of mortality. We hypothesized that peritoneal negative pressure therapy (NPT) would reduce systemic inflammation and organ damage...
  61. ncbi Sepsis and the heart
    M W Merx
    Department of Medicine, RWTH Aachen University, Aachen, Germany
    Circulation 116:793-802. 2007
    b>Sepsis is generally viewed as a disease aggravated by an inappropriate immune response encountered in the afflicted individual...
  62. pmc Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis
    Konstantinos Kambas
    First Department of Internal Medicine, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    PLoS ONE 7:e45427. 2012
    b>Sepsis is associated with systemic inflammatory responses and induction of coagulation system...
  63. pmc Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis
    Pascal M Lavoie
    Child and Family Research Institute, Vancouver, British Columbia, Canada
    J Infect Dis 202:1754-63. 2010
    ..Infants born prematurely are highly vulnerable to infections and also exhibit a high susceptibility to organ damage due to inflammation...
  64. ncbi Neutrophils in development of multiple organ failure in sepsis
    K A Brown
    Division of Medical Education, King s College School of Medicine, London, UK
    Lancet 368:157-69. 2006
    Multiple organ failure is a major threat to the survival of patients with sepsis and systemic inflammation. In the UK and in the USA, mortality rates are currently comparable with and projected to exceed those from myocardial infarction...
  65. ncbi Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis
    Seth W Glickman
    Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Acad Emerg Med 17:383-90. 2010
    ..To enhance the ability to intervene in patients with lesser illness severity, a better understanding of the natural history of the early progression from simple infection to more severe illness is needed...
  66. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
    ..response to infection, which is a progressive injurious process that falls under the generalized term 'sepsis' and includes sepsis-associated organ dysfunction as well...
  67. pmc The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*
    Shevin T Jacob
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA
    Crit Care Med 40:2050-8. 2012
    In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers.
  68. doi Reduced mortality after the implementation of a protocol for the early detection of severe sepsis
    Glauco A Westphal
    Hospital Municipal São José, Joinville, Brazil 89202 000
    J Crit Care 26:76-81. 2011
    We evaluate the impact that implementing an in-hospital protocol for the early detection of sepsis risk has on mortality from severe sepsis/septic shock.
  69. pmc The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
    Crit Care 14:R182. 2010
    Previous reports suggest that endothelial activation is an important process in sepsis pathogenesis...
  70. doi Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker
    Vineet Bhandari
    Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, LCI 401B, PO Box 208064, New Haven, CT 06520 8064, USA
    Pediatrics 121:129-34. 2008
    The goal was to determine the utility of neutrophil CD64 as a diagnostic marker for sepsis in neonates.
  71. doi Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality
    Tommaso Mauri
    Dipartimento di Medicina Perioperatoria e Terapie Intensive, Azienda Ospedaliera San Gerardo di Monza, Via Pergolesi 33, 20052, Monza, Italy
    Intensive Care Med 36:621-9. 2010
    ..During sepsis a massive inflammatory activation and coagulation/fibrinolysis dysfunction occur...
  72. ncbi Gene-expression profiling of peripheral blood mononuclear cells in sepsis
    Benjamin M P Tang
    Department of Intensive Care Medicine, Nepean Hospital and Western Clinical School, University of Sydney, Penrith, NSW, Australia
    Crit Care Med 37:882-8. 2009
    It has been shown that gene-expression profiling of circulating neutrophils could identify signature genes of sepsis. However, whether similar transcriptional changes occurred in peripheral blood mononuclear cells (PBMC) was not known...
  73. pmc Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis
    Jean Marc Cavaillon
    Cytokines and Inflammation Unit, Institut Pasteur, rue Dr Roux, 75015 Paris, France
    Crit Care 10:233. 2006
    ..However, altered responsiveness to LPS of leukocytes from sepsis and SIRS patients is not synonymous with a global down-regulation of cellular reactivity...
  74. ncbi Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations
    Kenneth L Becker
    Veterans Affairs Medical Center, Washington, DC, USA
    Crit Care Med 36:941-52. 2008
    ..ProCT) as a marker of several clinical conditions, in particular, systemic inflammation, infection, and sepsis, will be clarified, and its current limitations will be delineated...
  75. pmc FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis
    Menna R Clatworthy
    The Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, CB2 2XY, UK
    J Exp Med 199:717-23. 2004
    ..This correlated with increased production of the sepsis-associated cytokines tumor necrosis factor alpha and interleukin 6...
  76. pmc Calpain activity and muscle wasting in sepsis
    Ira J Smith
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 295:E762-71. 2008
    Muscle wasting in sepsis reflects activation of multiple proteolytic mechanisms, including lyosomal and ubiquitin-proteasome-dependent protein breakdown...
  77. doi Neutrophil-derived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis
    Stefan Margraf
    Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Shock 30:352-8. 2008
    ..Here, we studied the putative predictive value of plasma cf-DNA/NETs for the development of sepsis and mortality after multiple trauma...
  78. pmc Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
    Song Hui Jia
    Department of Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    J Clin Invest 113:1318-27. 2004
    ..PBEF is also expressed in neutrophils from critically ill patients with sepsis in whom rates of apoptosis are profoundly delayed...
  79. ncbi LPS induction of gene expression in human monocytes
    M Guha
    Departments of Immunology, C-204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Signal 13:85-94. 2001
    ..These signaling pathways in turn activate a variety of transcription factors that include NF-kappaB (p50/p65) and AP-1 (c-Fos/c-Jun), which coordinate the induction of many genes encoding inflammatory mediators...
  80. ncbi Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    N Engl J Med 347:240-7. 2002
    It is uncertain whether the rates and causes of early-onset sepsis (that occurring within 72 hours after birth) among very-low-birth-weight infants have changed in recent years, since antibiotics have begun to be used more widely during ..
  81. doi Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
    Serum lactate is a potentially useful biomarker to risk-stratify patients with severe sepsis; however, it is plausible that elevated serum lactate is simply a manifestation of clinically apparent organ dysfunction and/or shock (i.e...
  82. pmc Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R94. 2010
    Ghrelin has been recently identified as a mediator of various beneficial effects in animal models of sepsis. At present, no data are available concerning specific properties of ghrelin in critically ill patients from large cohorts...
  83. pmc Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    Antimicrob Agents Chemother 54:4851-63. 2010
    ..the effect of appropriate empirical antibiotic treatment on all-cause mortality among adult inpatients with sepsis. Two reviewers independently extracted data. Risk of bias was assessed using the Newcastle-Ottawa score...
  84. doi Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    J Antimicrob Chemother 64:142-50. 2009
    ..of meropenem administered by intermittent bolus dosing or continuous infusion to critically ill patients with sepsis and without renal dysfunction, and to use population pharmacokinetic modelling and Monte Carlo simulations to ..
  85. doi Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial
    Christian Meisel
    Department of Medical Immunology, Charite Campus Mitte, Berlin, Germany
    Am J Respir Crit Care Med 180:640-8. 2009
    Sustained sepsis-associated immunosuppression is associated with uncontrolled infection, multiple organ dysfunction, and death.
  86. pmc Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R179. 2010
    ..and insulin resistance are well-known features of critical illness and impact the mortality rate, especially in sepsis. Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients ..
  87. pmc Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients
    Andreas Hillenbrand
    Department of General, Visceral, and Transplantation Surgery, University Hospital of Ulm, Steinhoevelstr, Ulm, Germany
    BMC Surg 10:26. 2010
    ..In this study we examined the serum adipocytokine profile in critically ill patients, MO patients, and healthy blood donors...
  88. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
    ..Therefore, the incidence of ARF was investigated in 185 sepsis patients admitted in a surgical ICU during a 16-mo period...
  89. pmc Urinary cystatin C is diagnostic of acute kidney injury and sepsis, and predicts mortality in the intensive care unit
    Maryam Nejat
    Department of Medicine, University of Otago Christchurch, Riccarton Avenue, Christchurch 8140, New Zealand
    Crit Care 14:R85. 2010
    To evaluate the utility of urinary cystatin C (uCysC) as a diagnostic marker of acute kidney injury (AKI) and sepsis, and predictor of mortality in critically ill patients.
  90. pmc Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis
    Christine Dierkes
    Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    BMC Infect Dis 9:126. 2009
    ..We analyzed the clinical impact of a commercially available multiplex PCR system in patients with suspected sepsis.
  91. pmc Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit
    Katsunori Yanagihara
    Department of Laboratory Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki City, Nagasaki 852 8501, Japan
    Crit Care 14:R159. 2010
    b>Sepsis is a serious medical condition that requires rapidly administered, appropriate antibiotic treatment. Conventional methods take three or more days for final pathogen identification and antimicrobial susceptibility testing...
  92. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ..left ventricular preload is critical to achieve adequate fluid resuscitation in patients with hypotension and sepsis. This prospective study tested the correlation of the pulmonary artery occlusion pressure, the left ventricular ..
  93. ncbi Statins and sepsis: multiple modifications at multiple levels
    Marius Terblanche
    Department of Critical Care Medicine, St Thomas Hospital, London, UK
    Lancet Infect Dis 7:358-68. 2007
    b>Sepsis, an infection-induced inflammatory syndrome, is a leading and increasing cause of mortality worldwide...
  94. ncbi Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
    Clin Chem 52:112-9. 2006
    ..We present a method for quantifying AVP release by use of copeptin, a glycopeptide comprising the C-terminal part of the AVP prohormone...
  95. ncbi Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    Clin J Am Soc Nephrol 2:431-9. 2007
    b>Sepsis is the most common cause of acute kidney injury (AKI) in critical illness, but there is limited information on septic AKI...
  96. pmc Early acute kidney injury and sepsis: a multicentre evaluation
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, 3C1, 12 Walter C Mackenzie Centrel, University of Alberta Hospital, University of Alberta, 8440 112 St NW, Edmonton, Alberta, T6G2B7 Canada
    Crit Care 12:R47. 2008
    We conducted a study to evaluate the incidence, risk factors and outcomes associated with early acute kidney injury (AKI) in sepsis.
  97. ncbi Estimating the causes of 4 million neonatal deaths in the year 2000
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, 11 South Way, Pinelands, Cape Town 7405, South Africa
    Int J Epidemiol 35:706-18. 2006
    ..was to estimate, by country for the year 2000, the distribution of neonatal deaths across programme-relevant causes including: asphyxia, preterm birth, congenital abnormalities, sepsis/pneumonia, neonatal tetanus, diarrhoea, and 'other'.
  98. pmc Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients
    Andrew Rhodes
    Intensive Care Unit, St Georges s Hospital, London, UK
    Crit Care 10:R60. 2006
    ..The present study assesses the significance of raised levels of plasma DNA on admission to the intensive care unit (ICU) in terms of its ability to predict disease severity or prognosis...
  99. ncbi Aetiology of neonatal sepsis in Blantyre, Malawi: 1996-2001
    J Milledge
    Department of Paediatrics, College of Medicine, Blantyre, Malawi
    Ann Trop Paediatr 25:101-10. 2005
    The aim of this retrospective study was to report causes, antibiotic resistance and outcome of neonatal sepsis (often fatal in developing countries) in Malawi.
  100. pmc MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    Matthew J Delano
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 204:1463-74. 2007
    Polymicrobial sepsis alters the adaptive immune response and induces T cell suppression and Th2 immune polarization...
  101. doi Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis
    A Castellheim
    Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Oslo, Norway
    Scand J Immunol 69:479-91. 2009
    ..is called systemic inflammatory response syndrome (SIRS) and infection-induced systemic immune response is called sepsis. The host inflammatory response in SIRS and sepsis is similar and may lead to multiple organ dysfunction syndrome (..

Research Grants83

  1. Impact of Antibiotics and Vaccines on the in vivo Evolution of S. pneumoniae
    Garth Ehrlich; Fiscal Year: 2009
    ..of many human diseases including ear infections, pneumonia, meningitis (infection of the tissue lining the brain), sepsis, and infectious arthritis, moreover it is the cause of over one million deaths per year worldwide...
  2. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    Despite advances in the treatment of patients with sepsis, sepsis remains the second most common cause of death in non-coronary intensive care units and the tenth leading cause of death overall in high-income countries...
  3. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..antimicrobial agents, improved supportive care, and the introduction of an FDA approved adjunctive therapy for sepsis, (Xigris(r), drotrecogin alfa), the mortality rate for severe sepsis and septic shock of 30-60% remains high...
  4. A Novel Drug for Septicemia Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2009
    ..antimicrobial agents, improved supportive care, and the introduction of an FDA approved adjunctive therapy for sepsis, (Xigris(r), drotrecogin alfa), the mortality rate for severe sepsis and septic shock of 30-60% remains high...
  5. Preclinical Studies of Carbo-etomidate: An Etomidate Analogue for Use in Sepsis
    Douglas E Raines; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sepsis is the systemic inflammatory response syndrome that occurs during infection...
  6. Molecular Biology of Hemorrhagic Schock
    Timothy Billiar; Fiscal Year: 2004
    ..changes and organ dysfunction contribute to the susceptibility of the trauma victim to delayed infection and sepsis through the activation of counter-inflammatory mediators, rendering the host immunosuppressed...
  7. Molecular Biology of Hemorrhagic Schock
    Timothy Billiar; Fiscal Year: 2006
    ..changes and organ dysfunction contribute to the susceptibility of the trauma victim to delayed infection and sepsis through the activation of counter-inflammatory mediators, rendering the host immunosuppressed...
  8. Molecular Biology of Hemorrhagic Schock
    Timothy Billiar; Fiscal Year: 2005
    ..changes and organ dysfunction contribute to the susceptibility of the trauma victim to delayed infection and sepsis through the activation of counter-inflammatory mediators, rendering the host immunosuppressed...
  9. Molecular Biology of Hemorrhagic Schock
    Timothy Billiar; Fiscal Year: 2007
    ..changes and organ dysfunction contribute to the susceptibility of the trauma victim to delayed infection and sepsis through the activation of counter-inflammatory mediators, rendering the host immunosuppressed...
  10. Preventing Maternal and Neonatal Bacterial Infections in Developing Settings
    Shabir Madhi; Fiscal Year: 2007
    ..the burden of disease, risk factorsfor and potential to intervene against neonatal and maternalperi-partum sepsis in a developingcountry setting with a high prevalence(29%)of maternal HIV infection...
  11. AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATION
    David Williams; Fiscal Year: 1999
    b>Sepsis syndrome and septic shock are significant causes of morbidity and mortality in critically ill patients...
  12. Mechanisms of Novel Herbal Therapies for Sepsis.
    Haichao Wang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Despite recent advance in antibiotic therapy and intensive care, sepsis remains the most common cause of death in the intensive care units, claiming >225,000 victims annually in the U.S. alone...
  13. PRIMATE MODEL AND PATHOGENESIS OF ANTHRAX SEPSIS
    Shinichiro Kurosawa; Fiscal Year: 2006
    ..coli-mediated sepsis. Activated protein C (APC), a member of the protein C pathway, is an important regulator of this host coagulation ..
  14. PRIMATE MODEL AND PATHOGENESIS OF ANTHRAX SEPSIS
    Shinichiro Kurosawa; Fiscal Year: 2005
    ..coli-mediated sepsis. Activated protein C (APC), a member of the protein C pathway, is an important regulator of this host coagulation ..
  15. PRIMATE MODEL AND PATHOGENESIS OF ANTHRAX SEPSIS
    Shinichiro Kurosawa; Fiscal Year: 2007
    ..coli-mediated sepsis. Activated protein C (APC), a member of the protein C pathway, is an important regulator of this host coagulation ..
  16. PRIMATE MODEL AND PATHOGENESIS OF ANTHRAX SEPSIS
    Shinichiro Kurosawa; Fiscal Year: 2009
    ..coli-mediated sepsis. Activated protein C (APC), a member of the protein C pathway, is an important regulator of this host coagulation ..
  17. Targeted Suppression of Cytokine Signaling in the Acute Phase Response
    JACK HAWIGER; Fiscal Year: 2009
    ..provided by applicant): Inflammation, as the major mechanism of disease, underlies vascular system collapse in sepsis ("septic shock") and the development of atherosclerosis...
  18. Targeted Suppression of Cytokine Signaling in the Acute Phase Response
    JACK J HAWIGER; Fiscal Year: 2010
    ..provided by applicant): Inflammation, as the major mechanism of disease, underlies vascular system collapse in sepsis ("septic shock") and the development of atherosclerosis...
  19. Resistance of Beta 2 Microglobulin Null Mice to Sepsis
    Edward Sherwood; Fiscal Year: 2007
    ..Compared to wild type mice, beta2 microglobulin knockout mice exhibit improved survival during sepsis caused by cecal ligation and puncture (CLP)...
  20. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 2009
    ..identifying molecular mechanisms that negatively regulate Toll-like receptor (TLR) function and inflammation in sepsis. During the past funding cycle several major findings have provided a new direction and focus...
  21. Resistance of Beta 2 Microglobulin Null Mice to Sepsis
    Edward Sherwood; Fiscal Year: 2009
    ..Compared to wild type mice, beta2 microglobulin knockout mice exhibit improved survival during sepsis caused by cecal ligation and puncture (CLP)...
  22. Resistance of Beta 2 Microglobulin Null Mice to Sepsis
    Edward Sherwood; Fiscal Year: 2004
    ..Compared to wild type mice, beta2 microglobulin knockout mice exhibit improved survival during sepsis caused by cecal ligation and puncture (CLP)...
  23. Resistance of Beta 2 Microglobulin Null Mice to Sepsis
    Edward Sherwood; Fiscal Year: 2005
    ..Compared to wild type mice, beta2 microglobulin knockout mice exhibit improved survival during sepsis caused by cecal ligation and puncture (CLP)...
  24. Resistance of Beta 2 Microglobulin Null Mice to Sepsis
    Edward Sherwood; Fiscal Year: 2003
    ..Compared to wild type mice, beta2 microglobulin knockout mice exhibit improved survival during sepsis caused by cecal ligation and puncture (CLP)...
  25. Resistance of Beta 2 Microglobulin Null Mice to Sepsis
    Edward Sherwood; Fiscal Year: 2006
    ..Compared to wild type mice, beta2 microglobulin knockout mice exhibit improved survival during sepsis caused by cecal ligation and puncture (CLP)...
  26. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2004
    ..and cytokines mediators, circulating factors produced by the innate immune system, as critical mediators of sepsis-related tissue injury and death...
  27. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants...
  28. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    James Mapes; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants...
  29. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    James Mapes; Fiscal Year: 2009
    Project Summary/Abstract: Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants. Over 20% of all VLBW infants experience one or more episodes of late-onset sepsis...
  30. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..and cytokines mediators, circulating factors produced by the innate immune system, as critical mediators of sepsis-related tissue injury and death...
  31. Microthrombus Formation Triggers Lung Injury in Sepsis
    Bruce Harms; Fiscal Year: 2009
    ..widely believed that cytotoxic agents released by neutrophils, the white blood cells that invade the lung during sepsis, cause the initial alveolar injury. However, the trigger that causes this neutrophil invasion is unknown...
  32. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    James Mapes; Fiscal Year: 2007
    b>Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants. Over 20% of all VLBW infants experience one or more episodes of late-onset sepsis...
  33. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2000
    Previous studies suggest that sepsis-induced muscle catabolism reflects ubiquitin-proteasome-dependent degradation of myofibrillar proteins regulated by glucocorticoids...
  34. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2003
    Previous studies suggest that sepsis-induced muscle catabolism reflects ubiquitin-proteasome-dependent degradation of myofibrillar proteins regulated by glucocorticoids...
  35. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2001
    Previous studies suggest that sepsis-induced muscle catabolism reflects ubiquitin-proteasome-dependent degradation of myofibrillar proteins regulated by glucocorticoids...
  36. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
    ..those severely injured trauma patient with systemic inflammatory response syndrome (SIRS) who will develop the sepsis pathology...
  37. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2002
    Previous studies suggest that sepsis-induced muscle catabolism reflects ubiquitin-proteasome-dependent degradation of myofibrillar proteins regulated by glucocorticoids...
  38. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2001
    Previous studies suggest that sepsis-induced muscle catabolism reflects ubiquitin-proteasome-dependent degradation of myofibrillar proteins regulated by glucocorticoids...
  39. Critical Care Excellence in Sepsis and Trauma (CREST)
    Dee Ford; Fiscal Year: 2009
    ..A quasi-experimental clinical trial will test the effectiveness of the Critical Care Excellence in Sepsis and Trauma Program (CREST)...
  40. Critical Care Excellence in Sepsis and Trauma (CREST)
    DEE WALKER contact FORD; Fiscal Year: 2010
    ..A quasi-experimental clinical trial will test the effectiveness of the Critical Care Excellence in Sepsis and Trauma Program (CREST)...
  41. Resistance of Beta 2 Microglobulin Null Mice to Sepsis
    Edward Sherwood; Fiscal Year: 2009
    We have convincingly shown that natural killer (NK) cells facilitate the pathogenesis of sepsis caused by cecal ligation and puncture (CLP)...
  42. Innate immunity and cardiovascular function in sepsis
    Chuanfu Li; Fiscal Year: 2009
    The critically ill patient frequently develops a complex disease spectrum that includes sepsis syndrome and/or septic shock. A major cause of delayed deaths in the critically ill patient is multiple organ dysfunction syndrome (MODS)...
  43. Innate immunity and cardiovascular function in sepsis
    David L Williams; Fiscal Year: 2010
    The critically ill patient frequently develops a complex disease spectrum that includes sepsis syndrome and/or septic shock. A major cause of delayed deaths in the critically ill patient is multiple organ dysfunction syndrome (MODS)...
  44. CONTRIBUTION OF LPS TO EXP ENTEROCOCCAL SEPSIS
    Christopher Papasian; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Severe sepsis and septic shock secondary to Gram-positive bacterial pathogen infection is increasingly recognized in a recent series of patients with sepsis from the USA and other ..
  45. Protocolized Care for Early Septic Shock (ProCESS)
    Derek C Angus; Fiscal Year: 2012
    PROVIDED. Severe sepsis is the syndrome of acute organ dysfunction secondary to infection. It affects 750,000 Americans each year, with a mortality of 30%...
  46. Protocolized Care for Early Septic Shock (ProCESS)
    Derek Angus; Fiscal Year: 2006
    Severe sepsis is the syndrome of acute organ dysfunction secondary to infection. It affects 750,000 Americans each year, with a mortality of 30%...
  47. Protocolized Care for Early Septic Shock (ProCESS)
    Derek C Angus; Fiscal Year: 2010
    Severe sepsis is the syndrome of acute organ dysfunction secondary to infection. It affects 750,000 Americans each year, with a mortality of 30%...
  48. Protocolized Care for Early Septic Shock (ProCESS)
    Derek Angus; Fiscal Year: 2009
    Severe sepsis is the syndrome of acute organ dysfunction secondary to infection. It affects 750,000 Americans each year, with a mortality of 30%...
  49. Protocolized Care for Early Septic Shock (ProCESS)
    Derek Angus; Fiscal Year: 2007
    Severe sepsis is the syndrome of acute organ dysfunction secondary to infection. It affects 750,000 Americans each year, with a mortality of 30%...
  50. HDL Modulation of monocyte function in endotoxemia
    C Roger White; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sepsis is a major cause of death in hospitalized patients...
  51. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sepsis is a major cause of death in hospitalized patients...
  52. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sepsis is a major cause of death in hospitalized patients...
  53. Adrenergic Control of Stem Cell Lineage Commitment in Sepsis
    KUZHALI MUTHUMALAIAPPAN; Fiscal Year: 2009
    ..Central to the patho-physiology of burn sepsis is the sequential change in macrophage cytokine signals (hyper response to hypo response) in the periphery and in ..
  54. Protocolized Care for Early Septic Shock (ProCESS)
    Derek Angus; Fiscal Year: 2009
    Severe sepsis is the syndrome of acute organ dysfunction secondary to infection. It affects 750,000 Americans each year, with a mortality of 30%...
  55. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2006
    Critical injury and sepsis continues to be a major health concern in the US. Many of these patients succumb to infections that lead to unabated systemic inflammatory response and multiple organ failure...
  56. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2007
    Critical injury and sepsis continues to be a major health concern in the US. Many of these patients succumb to infections that lead to unabated systemic inflammatory response and multiple organ failure...
  57. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2005
    Critical injury and sepsis continues to be a major health concern in the US. Many of these patients succumb to infections that lead to unabated systemic inflammatory response and multiple organ failure...
  58. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2004
    Critical injury and sepsis continues to be a major health concern in the US. Many of these patients succumb to infections that lead to unabated systemic inflammatory response and multiple organ failure...
  59. Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
    MARK PERRELLA; Fiscal Year: 2007
    b>Sepsis is a disease process representing the systemic response to severe infection...
  60. PROGRAMMED CELL DEATH--ROLE IN SEPTIC IMMUNE SUPPRESSION
    Alfred Ayala; Fiscal Year: 1999
    ..use of specific antibiotics, aggressive operative intervention, and the nutritional support of trauma patients, sepsis and multiple organ failure continue to be a major problem in the surgical intensive care units...
  61. Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
    MARK PERRELLA; Fiscal Year: 2005
    b>Sepsis is a disease process representing the systemic response to severe infection...
  62. Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
    MARK PERRELLA; Fiscal Year: 2006
    b>Sepsis is a disease process representing the systemic response to severe infection...
  63. Angiopoietin Mechanisms in Sepsis
    Samir Parikh; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sepsis affects more than 300,000 individuals in the US annually, costs more than $16 billion/yr to treat, is associated with an acute mortality of 30%, and is expected to increase in incidence, making ..
  64. Angiopoietin Mechanisms in Sepsis
    Samir Parikh; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sepsis affects more than 300,000 individuals in the US annually, costs more than $16 billion/yr to treat, is associated with an acute mortality of 30%, and is expected to increase in incidence, making ..
  65. Angiopoietin Mechanisms in Sepsis
    Samir M Parikh; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sepsis affects more than 300,000 individuals in the US annually, costs more than $16 billion/yr to treat, is associated with an acute mortality of 30%, and is expected to increase in incidence, making ..
  66. ClC-3 ion transport modulates NADPH oxidase-dependent PMN priming by endotoxin
    Jessica Moreland; Fiscal Year: 2009
    The mortality from Gram-negative sepsis arises from development of the sepsis syndrome with uncontrolled systemic inflammation...
  67. Extracorporeal Blood Purification For Sepsis Therapy
    Susan Szathmary; Fiscal Year: 2006
    ..constituents can result in an overwhelming systemic inflammatory response and procoagulant state leading to sepsis, septic shock and death...
  68. Diaphragm Mitochondrial Alterations in Sepsis
    Leigh Callahan; Fiscal Year: 2001
    DESCRIPTION (Applicant's abstract): Recent work suggests that mitochondria dysfunction plays a central role in sepsis, a major cause of death and morbidity in the United States...
  69. Diaphragm Mitochondrial Alterations in Sepsis
    Leigh Callahan; Fiscal Year: 2002
    DESCRIPTION (Applicant's abstract): Recent work suggests that mitochondria dysfunction plays a central role in sepsis, a major cause of death and morbidity in the United States...
  70. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2000
    b>Sepsis is that critical condition of the patient which, if uncorrected, leads to death. The initial hyperglycemia seen in sepsis is followed by hypoglycemia with concomitant hyperlacticacidemia...
  71. A Novel Therapy for Septic Shock
    Rongqian Wu; Fiscal Year: 2009
    This SBIR Phase I/Phase II Fast-Track proposal is intended to develop a novel therapy for patients with sepsis and septic shock. Septic shock is the leading cause of death in non-cardiac intensive care units...
  72. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2009
    Previous studies suggest that sepsis-induced muscle wasting is associated with increased muscle calcium levels and that glucocorticoids are the predominant mediator of sepsis-induced muscle proteolysis...
  73. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 1999
    b>Sepsis is that critical condition of the patient which, if uncorrected, leads to death. The initial hyperglycemia seen in sepsis is followed by hypoglycemia with concomitant hyperlacticacidemia...
  74. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2006
    Previous studies suggest that sepsis-induced muscle wasting is associated with increased muscle calcium levels and that glucocorticoids are the predominant mediator of sepsis-induced muscle proteolysis...
  75. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2007
    Previous studies suggest that sepsis-induced muscle wasting is associated with increased muscle calcium levels and that glucocorticoids are the predominant mediator of sepsis-induced muscle proteolysis...
  76. ROLE OF EICOSANOIDS IN SHOCK
    James A Cook; Fiscal Year: 2010
    ..identifying molecular mechanisms that negatively regulate Toll-like receptor (TLR) function and inflammation in sepsis. During the past funding cycle several major findings have provided a new direction and focus...
  77. ROLE OF EICOSANOIDS IN SHOCK
    James Cook; Fiscal Year: 2009
    ..identifying molecular mechanisms that negatively regulate Toll-like receptor (TLR) function and inflammation in sepsis. During the past funding cycle several major findings have provided a new direction and focus...
  78. A novel treatment, TAT-HSP70, in attenuating lung injury in sepsis induced ARDS
    MARY MELANIE LYONS; Fiscal Year: 2010
    ..mortality and increasing locomotor activity in a cecal ligation and double puncture (2CLP) rodent model of sepsis induced Acute Respiratory Distress Syndrome (ARDS)...
  79. Radiation Combined Injury: Mechanisms and Therapeutic Approaches
    Ping Wang; Fiscal Year: 2010
    ..radiation exposure scenario, radiation victims likely suffer from additional injuries such as infection and sepsis. Despite advances in our understanding of radiation injury or advances in the management of sepsis patients, ..
  80. Radiation Combined Injury: Mechanisms and Therapeutic Approaches
    Ping Wang; Fiscal Year: 2010
    ..radiation exposure scenario, radiation victims likely suffer from additional injuries such as infection and sepsis. Despite advances in our understanding of radiation injury or advances in the management of sepsis patients, ..
  81. Radiation Combined Injury: Mechanisms and Therapeutic Approaches
    Ping Wang; Fiscal Year: 2009
    ..radiation exposure scenario, radiation victims likely suffer from additional injuries such as infection and sepsis. Despite advances in our understanding of radiation injury or advances in the management of sepsis patients, ..
  82. Resistance of Beta 2 Microglobulin Null Mice to Sepsis
    Edward R Sherwood; Fiscal Year: 2010
    We have convincingly shown that natural killer (NK) cells facilitate the pathogenesis of sepsis caused by cecal ligation and puncture (CLP)...
  83. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sepsis is a disease process representing the systemic response to severe infection...