Genomes and Genes
Summary: Any infection which a patient contracts in a health-care institution.
Publications336 found, 100 shown here
- CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care settingTeresa C Horan
National Healthcare Safety Network, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Infect Control 36:309-32. 2008
- Invasive methicillin-resistant Staphylococcus aureus infections in the United StatesR Monina Klevens
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
JAMA 298:1763-71. 2007..As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed...
- Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureusM C Enright
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
J Clin Microbiol 38:1008-15. 2000..MLST provides an unambiguous method for assigning MRSA and MSSA isolates to known clones or assigning them as novel clones via the Internet...
- Waves of resistance: Staphylococcus aureus in the antibiotic eraHenry F Chambers
Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
Nat Rev Microbiol 7:629-41. 2009..Here, we review the molecular epidemiology of the epidemic waves of penicillin- and methicillin-resistant strains of S. aureus that have occurred since 1940, with a focus on the clinical and molecular epidemiology of CA-MRSA...
- Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance studyHilmar Wisplinghoff
Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
Clin Infect Dis 39:309-17. 2004..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
- NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007Alicia I Hidron
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA
Infect Control Hosp Epidemiol 29:996-1011. 2008....
- An intervention to decrease catheter-related bloodstream infections in the ICUPeter Pronovost
School of Medicine, Johns Hopkins University, Baltimore, USA
N Engl J Med 355:2725-32. 2006..Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal...
- CDC definitions for nosocomial infections, 1988J S Garner
Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia
Am J Infect Control 16:128-40. 1988..Other hospitals may wish to adopt or modify them for use in their nosocomial infections surveillance programs...
- A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortalityVivian G Loo
Department of Microbiology, McGill University Health Center, Montreal, Que, Canada
N Engl J Med 353:2442-9. 2005..In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile-associated diarrhea...
- Estimating health care-associated infections and deaths in U.S. hospitals, 2002R Monina Klevens
Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS A 24, Atlanta, GA 30333, USA
Public Health Rep 122:160-6. 2007..The purpose of this study was to provide a national estimate of the number of healthcare-associated infections (HAI) and deaths in United States hospitals...
- An increasing threat in hospitals: multidrug-resistant Acinetobacter baumanniiLenie Dijkshoorn
Department of Infectious Diseases C5 P, Leiden University Medical Centre, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
Nat Rev Microbiol 5:939-51. 2007..Here, we present an overview of the current knowledge of the genus Acinetobacter, with the emphasis on the clinically most important species, Acinetobacter baumannii...
- Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infectionTimothy S Naimi
Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
JAMA 290:2976-84. 2003..However, MRSA has emerged in patients without established risk factors (community-associated MRSA)...
- Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control ProgrammeD Pittet
Department of Internal Medicine, University of Geneva Hospitals, and Institute of Social and Preventive Medicine, University of Geneva, Switzerland
Lancet 356:1307-12. 2000Hand hygiene prevents cross infection in hospitals, but compliance with recommended instructions is commonly poor...
- The changing epidemiology of Clostridium difficile infectionsJ Freeman
Department of Microbiology, Old Medical School, Leeds Teaching Hospitals and University of Leeds, Leeds, United Kingdom
Clin Microbiol Rev 23:529-49. 2010..difficile, and the effect of the use of alcohol-based hand hygiene agents...
- Global challenge of multidrug-resistant Acinetobacter baumanniiFederico Perez
Division of Infectious Diseases and HIV Medicine, University Hospitals, Case Medical Centers, Cleveland, OH, USA
Antimicrob Agents Chemother 51:3471-84. 2007
- Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infectionsN Deborah Friedman
Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
Ann Intern Med 137:791-7. 2002..Bloodstream infections occurring in persons residing in the community, regardless of whether those persons have been receiving health care in an outpatient facility, have traditionally been categorized as community-acquired infections...
- Transmission of influenza A in human beingsGabrielle Brankston
Infection Prevention and Control Unit, University Health Network, Toronto, Ontario, Canada
Lancet Infect Dis 7:257-65. 2007..Further research is required to better define conditions under which the influenza virus may transmit via the airborne route...
- Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysisBenedetta Allegranzi
First Global Patient Safety Challenge, WHO Patient Safety, Geneva, Switzerland
Lancet 377:228-41. 2011..We aimed to assess the epidemiology of endemic health-care-associated infection in developing countries...
- Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriersHeiman F L Wertheim
Erasmus MC, University Medical Centre, Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
Lancet 364:703-5. 2004..006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous...
- Clostridium difficile--more difficult than everCiaran P Kelly
Gastroenterology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 359:1932-40. 2008
- Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infectionsUlrich Seybold
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Clin Infect Dis 42:647-56. 2006..Whether community-associated methicillin-resistant Staphylococcus aureus (MRSA) genotypes (e.g., USA300) are a major cause of bloodstream infections (BSIs) and health care-associated infections has been poorly defined...
- Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and EuropeMichel Warny
Acambis Inc, Cambridge, MA, USA
Lancet 366:1079-84. 2005..We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains...
- Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortalityMatthew Morrell
Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
Antimicrob Agents Chemother 49:3640-5. 2005..Alternatively, increased use of empiric antifungal treatment in selected patients at high risk for fungal bloodstream infection could also reduce delays in treatment...
- How long do nosocomial pathogens persist on inanimate surfaces? A systematic reviewAxel Kramer
Institut fur Hygiene und Umweltmedizin, Ernst Moritz Arndt Universitat, Greifswald, Germany
BMC Infect Dis 6:130. 2006..Inanimate surfaces have often been described as the source for outbreaks of nosocomial infections. The aim of this review is to summarize data on the persistence of different nosocomial pathogens on inanimate surfaces...
- International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003-2008, issued June 2009Victor D Rosenthal
International Nosocomial Infection Control Consortium, Buenos Aires, Argentina
Am J Infect Control 38:95-104.e2. 2010..0% vs 20.2%, respectively) were also far higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 23.6% (CVC-associated bloodstream infections) to 29.3% (VAP)...
- Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threatHajo Grundmann
Centre for Infectious Diseases Epidemiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Lancet 368:874-85. 2006....
- Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in EuropeR Kock
Institute of Hygiene, University Hospital Muenster, Muenster, Germany
Euro Surveill 15:19688. 2010..Thereby, we aim at identifying unmet needs of surveillance, prevention and control of MRSA in Europe...
- Community-associated meticillin-resistant Staphylococcus aureus strains as a cause of healthcare-associated infectionJ A Otter
Directorate of Infection, King s College London and Guy s and St Thomas NHS Foundation Trust, London, UK
J Hosp Infect 79:189-93. 2011....
- Close encounters in a pediatric ward: measuring face-to-face proximity and mixing patterns with wearable sensorsLorenzo Isella
Complex Networks and Systems Group, Institute for Scientific Interchange Foundation, Torino, Italy
PLoS ONE 6:e17144. 2011..Mathematical models need to be informed with accurate data on contacts among individuals...
- Emergence of methicillin-resistant Staphylococcus aureus (MRSA) in different animal speciesChristiane Cuny
Robert Koch Institute, Wernigerode Branch, Burgstrasse 37, 38855 Wernigerode, Germany
Int J Med Microbiol 300:109-17. 2010..Mechanisms of host adaptation and their genomic background are poorly understood so far...
- Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typingA Sarah Walker
National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
PLoS Med 9:e1001172. 2012..This study aimed to investigate ward-based transmission of C. difficile, by subdividing outbreaks into distinct lineages defined by multi-locus sequence typing (MLST)...
- Nurse-staffing levels and the quality of care in hospitalsJack Needleman
Department of Health Policy and Management, Harvard School of Public Health, Boston, Mass 02115, USA
N Engl J Med 346:1715-22. 2002..It is uncertain whether lower levels of staffing by nurses at hospitals are associated with an increased risk that patients will have complications or die...
- Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residentsMichelle M Riggs
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Clin Infect Dis 45:992-8. 2007..Asymptomatic fecal carriage of Clostridium difficile is common in patients staying in health care facilities, but the importance of asymptomatic carriers with regard to disease transmission is unclear...
- Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort studyCorinne Alberti
Department of Biostatistics, Saint Louis Hospital, Paris, France
Intensive Care Med 28:108-21. 2002..To examine the incidence of infections and to describe them and their outcome in intensive care unit (ICU) patients...
- Evaluation of the national Cleanyourhands campaign to reduce Staphylococcus aureus bacteraemia and Clostridium difficile infection in hospitals in England and Wales by improved hand hygiene: four year, prospective, ecological, interrupted time series studSheldon Paul Stone
Royal Free Campus, University College London Medical School, London NW3 2PF, UK
BMJ 344:e3005. 2012....
- Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?Kyle J Popovich
Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
Clin Infect Dis 46:787-94. 2008..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
- Preventing surgical-site infections in nasal carriers of Staphylococcus aureusLonneke G M Bode
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
N Engl J Med 362:9-17. 2010..Nasal carriers of Staphylococcus aureus are at increased risk for health care-associated infections with this organism. Decolonization of nasal and extranasal sites on hospital admission may reduce this risk...
- Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitalsCarl T Bergstrom
Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
Proc Natl Acad Sci U S A 101:13285-90. 2004..As a consequence, cycling is unlikely to be effective and may even hinder resistance control. These results may explain the limited success reported thus far from clinical trials of antimicrobial cycling...
- Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPELouis B Rice
J Infect Dis 197:1079-81. 2008
- Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infectionsRajiv Jain
Patient Care Services, Veterans Affairs Central Office, and the VA Pittsburgh Healthcare System, Pittsburgh, USA
N Engl J Med 364:1419-30. 2011..Health care-associated infections with methicillin-resistant Staphylococcus aureus (MRSA) have been an increasing concern in Veterans Affairs (VA) hospitals...
- Transition of Enterococcus faecium from commensal organism to nosocomial pathogenRob Jl Willems
Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, CX Utrecht, The Netherlands
Future Microbiol 4:1125-35. 2009..We also discuss the role of the accessory genome of E. faecium in contributing to the infectious phenotype and examine the role that surface proteins of E. faecium may have in colonization and infection...
- Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitalsErica M C D'Agata
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Infect Dis 48:274-84. 2009..If true, this event would have serious consequences, because CA-MRSA infections in hospitals would occur among a more debilitated, older patient population...
- Staphylococcus aureus endocarditis: a consequence of medical progressVance G Fowler
Duke University Medical Center, Durham, NC 27710, USA
JAMA 293:3012-21. 2005..The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown...
- Transmissibility of livestock-associated methicillin-resistant Staphylococcus aureus (ST398) in Dutch hospitalsM W M Wassenberg
Department of Medical Microbiology, University Medical Centre Utrecht, The Netherlands
Clin Microbiol Infect 17:316-9. 2011..28 (95% CI 0.09-0.90), which was not sensitive to adjustment for duration of hospitalization at time of detection. Nosocomial transmission of ST398 MRSA is 72% less likely than that of non-ST398 MRSA strains...
- Emergence of CC17 Enterococcus faecium: from commensal to hospital-adapted pathogenJanetta Top
Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
FEMS Immunol Med Microbiol 52:297-308. 2008....
- The nosocomial transmission rate of animal-associated ST398 meticillin-resistant Staphylococcus aureusMartin C J Bootsma
Faculty of Science, Department of Mathematics, Utrecht University, CD Utrecht, The Netherlands
J R Soc Interface 8:578-84. 2011..The R(A) ratio between non-ST398 MRSA and ST398 was 5.90 (95% CI 2.24-23.81). ST398 is 5.9 times less transmissible than non-ST398 MRSA in Dutch hospitals, which may allow less stringent transmission-control measures for ST398 MRSA...
- MRSA prevalence in European healthcare settings: a reviewMadeleine Dulon
Institution for Statutory Accident Insurance and Prevention in the Health and Welfare Services, Department of Occupational Health Research, Pappelallee, Hamburg, Germany
BMC Infect Dis 11:138. 2011..This paper gives an overview of MRSA prevalence in hospitals and other healthcare institutions in non-outbreak situations in Western Europe...
- Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costsCraig A Umscheid
Center for Evidence Based Practice, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Infect Control Hosp Epidemiol 32:101-14. 2011..To estimate the proportion of healthcare-associated infections (HAIs) in US hospitals that are "reasonably preventable," along with their related mortality and costs...
- Management of multidrug-resistant enterococcal infectionsC A Arias
Department of Internal Medicine, Division of Infectious Diseases and Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School at Houston, Houston, TX, USA
Clin Microbiol Infect 16:555-62. 2010..Clinical studies evaluating new strategies, including combination therapies, to treat severe vancomycin-resistant E. faecium infections are urgently needed...
- Health care-associated invasive MRSA infections, 2005-2008Alexander J Kallen
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
JAMA 304:641-8. 2010..Whether there have been changes in MRSA infection incidence as these programs become established is unknown; however, recent data have shown that rates of MRSA bloodstream infections (BSIs) in intensive care units are decreasing...
- Methicillin-resistant Staphylococcus aureus in neonatal intensive care unitGili Regev-Yochay
Infectious Diseases Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Israel
Emerg Infect Dis 11:453-6. 2005..Fifteen infected neonates were identified, 2 of whom died. This outbreak illustrates how a rare community pathogen can rapidly spread through nosocomial transmission...
- Overview of nosocomial infections caused by gram-negative bacilliRobert Gaynes
Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 41:848-54. 2005..Gram-negative bacilli are commonly associated with hospital-acquired infections in ICUs. The proportion of Acinetobacter species associated with ICU pneumonia increased from 4% in 1986 to 7.0% in 2003...
- Epidemiology of methicillin-resistant Staphylococcus aureusHelen W Boucher
Division of Infectious Diseases, Tufts University Medical School and New England Medical Center, Boston, Massachussetts, USA
Clin Infect Dis 46:S344-9. 2008..We examine the trends in both nosocomial and community-associated MRSA infections and explore recent studies of the mechanisms that allow S. aureus to become resistant to currently available drugs...
- The evolution of Staphylococcus aureusRuud H Deurenberg
Department of Medical Microbiology, University Hospital Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands
Infect Genet Evol 8:747-63. 2008..This review describes the latest observations about the structure of SCCmec, the techniques used to study the molecular epidemiology and evolution of S. aureus as well as some challenges that researchers face in the future...
- Controlling nosocomial infection based on structure of hospital social networksTaro Ueno
Tokyo Metropolitan Hiroo General Hospital, 2 34 10 Ebisu, Shibuya, Tokyo 150 0013, Japan
J Theor Biol 254:655-66. 2008....
- Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patternsKhetam Hussein
Infectious Diseases Unit, Rambam Medical Center, Haifa, Israel
Infect Control Hosp Epidemiol 30:666-71. 2009..Carbapenem resistance among isolates of Klebsiella pneumoniae has been unusual...
- Intervention to reduce transmission of resistant bacteria in intensive careW Charles Huskins
Division of Pediatric Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA
N Engl J Med 364:1407-18. 2011..Intensive care units (ICUs) are high-risk settings for the transmission of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE)...
- Hospital-acquired neonatal infections in developing countriesAnita K M Zaidi
Department of Paediatrics and Child Health, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
Lancet 365:1175-88. 2005..Low-cost, "bundled" interventions using systems quality improvement approaches for improved infection control are possible, but should be supported by evidence in developing country settings...
- Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumoniaMarin H Kollef
Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
Chest 128:3854-62. 2005..Accumulating evidence suggests that health-care-associated infections are distinct from those that are truly community acquired...
- Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II groupMichele Iacono
National Research Council, Segrate, Milan 20090, Italy
Antimicrob Agents Chemother 52:2616-25. 2008..These findings provide novel insight into the genetic basis of A. baumannii resistance...
- 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care SettingsJane D Siegel
Am J Infect Control 35:S65-164. 2007
- Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in QuebecJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Que
CMAJ 173:1037-42. 2005..The effects of this epidemic on mortality and duration of hospital stay remain unknown. We measured these effects among patients admitted to a hospital in Quebec during 2003 and 2004...
- Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumoniaRonald N Jones
JMI Laboratories, North Liberty, Iowa 52317, USA
Clin Infect Dis 51:S81-7. 2010..These facts have profound impact on the choices of comparison therapies to be applied in contemporary new drug clinical trials for pneumonia...
- SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcusCarlene A Muto
Division of Hospital Epidemiology and Infection Control, UPMC P, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 24:362-86. 2003..After 2 more years without improvement, a SHEA task force was appointed to draft this evidence-based guideline on preventing nosocomial transmission of such pathogens, focusing on the two considered most out of control: MRSA and VRE...
- Role of hand hygiene in healthcare-associated infection preventionB Allegranzi
First Global Patient Safety Challenge, World Alliance for Patient Safety, IER PSP, Room L319, L Building, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
J Hosp Infect 73:305-15. 2009..We also report considerations and solutions resulting from the implementation of the multimodal strategy proposed in the WHO Guidelines on Hand Hygiene in Health Care...
- Antimicrobial resistance: the example of Staphylococcus aureusFranklin D Lowy
Departments of Medicine and Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 111:1265-73. 2003
- Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000-2006Kevin B Laupland
Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
J Infect Dis 198:336-43. 2008..We sought to describe the epidemiological profile of S. aureus bacteremia and to assess whether the incidence and severity of and the antimicrobial resistance rates associated with this bacteremia are increasing...
- The World Health Organization hand hygiene observation methodHugo Sax
Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, 1211 Geneva 14, Switzerland
Am J Infect Control 37:827-34. 2009..Sample size estimates, survey analysis and report, and major bias and confounding factors associated with observation are discussed...
- The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptionsM Lipsitch
Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 97:1938-43. 2000..The predictions of the model are compared with those of other models and published data. The implications for resistance control and study design are discussed, along with the limitations and assumptions of the model...
- Informed switching strongly decreases the prevalence of antibiotic resistance in hospital wardsRoger D Kouyos
Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland
PLoS Comput Biol 7:e1001094. 2011..Overall, our results suggest that switching between different antibiotics might be a valuable strategy in small patient populations, if the switching strategies take the frequencies of resistance alleles into account...
- Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infectionsCynthia L Maree
David Geffen School of Medicine, University of California, Los Angeles, California90509, USA
Emerg Infect Dis 13:236-42. 2007..In conclusion, MRSA isolates phenotypically similar to CA strains have become the predominant isolates associated with HA-MRSA in our hospital...
- Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitalsYudong Liu
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing
Antimicrob Agents Chemother 53:512-8. 2009..The prevalence of the Panton-Valentine leukocidin gene was 2.3%. The data documented two major epidemic MRSA clones, ST239-MRSA-SCCmec type III and ST5-MRSA-SCCmec type II, with unique geographic distributions across China...
- The population structure of Acinetobacter baumannii: expanding multiresistant clones from an ancestral susceptible genetic poolLaure Diancourt
Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France
PLoS ONE 5:e10034. 2010..This dichotomy indicates that antimicrobial resistance is a major selective advantage that drives the ongoing rapid clonal expansion of these highly problematic agents of nosocomial infections...
- Characterization of nasal and blood culture isolates of methicillin-resistant Staphylococcus aureus from patients in United States HospitalsFred C Tenover
Cepheid, Sunnyvale, California, USA
Antimicrob Agents Chemother 56:1324-30. 2012..S. hospitalized patients, USA100 isolates of multiple spa types, while still common in the nares, have been replaced by USA300 isolates as the predominant MRSA strain type in positive blood cultures...
- 'My five moments for hand hygiene': a user-centred design approach to understand, train, monitor and report hand hygieneH Sax
Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland Global Patient Safety Challenge, World Alliance for Patient Safety, World Health Organization, Geneva, Switzerland
J Hosp Infect 67:9-21. 2007..My five moments for hand hygiene' bridges the gap between scientific evidence and daily health practice and provides a solid basis to understand, teach, monitor and report hand hygiene practices...
- Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistanceHelen L Leavis
Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Curr Opin Microbiol 9:454-60. 2006..This complex is correlated with ampicillin and quinolone resistance and with the presence of a putative pathogenicity island. Preliminary MLST data suggest that similar hospital-adapted complexes might also exist in E. faecalis...
- Methicillin-resistant Staphylococcus aureus in hospitals and the community: stealth dynamics and control catastrophesB S Cooper
Department of Medical Microbiology, Royal Free and University College Medical School, University of London, WC1E 7HU, United Kingdom
Proc Natl Acad Sci U S A 101:10223-8. 2004..If resources do not scale with MRSA prevalence, isolation policies can fail "catastrophically."..
- Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) among pigs on German farms and import of livestock-related MRSA into hospitalsR Kock
Institute of Hygiene, University Hospital Munster, Robert Koch Str 41, 48149, Munster, Germany
Eur J Clin Microbiol Infect Dis 28:1375-82. 2009..Our results indicate that livestock represents a relevant reservoir for the import of MRSA into regional German hospitals...
- Antimicrobial susceptibility among organisms from the Asia/Pacific Rim, Europe and Latin and North America collected as part of TEST and the in vitro activity of tigecyclineRalf Rene Reinert
Institute for Medical Microbiology, National Reference Centre for Streptococci, Aachen, Germany
J Antimicrob Chemother 60:1018-29. 2007..To describe antimicrobial susceptibility among bacterial isolates associated with hospital infections collected from 266 centres in Asia/Pacific Rim (n = 1,947), North America (n = 24,283), Latin America (n = 1,957) and Europe (n = 8,796)...
- How important is patient-to-patient transmission in extended-spectrum beta-lactamase Escherichia coli acquisitionAnthony D Harris
Department of Epidemiology and Preventive Medicine, University of Maryland, 100 North Greene Street, Baltimore, MD 21201, USA
Am J Infect Control 35:97-101. 2007..The objective of this study was to quantify the amount of patient-to-patient transmission among patients who acquire an ESBL-producing E coli infection using perianal surveillance cultures in an intensive care unit (ICU) population...
- Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic reviewTim Planche
Department of Medical Microbiology, St George s Hospital, London, UK
Lancet Infect Dis 8:777-84. 2008..To improve diagnosis, we suggest a two-stage testing strategy for C difficile toxin with an initial highly sensitive rapid screening test to identify positive samples that are then confirmed by a reference method...
- Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitalsAri Robicsek
Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
Ann Intern Med 148:409-18. 2008..The effect of large-scale expanded surveillance for methicillin-resistant Staphylococcus aureus (MRSA) on health care-associated MRSA disease is not known...
- Assessing the role of undetected colonization and isolation precautions in reducing methicillin-resistant Staphylococcus aureus transmission in intensive care unitsTheodore Kypraios
School of Mathematical Sciences, University of Nottingham, Nottingham, UK
BMC Infect Dis 10:29. 2010..Recent methodological developments have made it possible to estimate these quantities using routine surveillance data...
- Analysis of clonality and antibiotic resistance among early clinical isolates of Enterococcus faecium in the United StatesJessica R Galloway-Peña
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
J Infect Dis 200:1566-73. 2009..The Enterococcus faecium genogroup, referred to as clonal complex 17 (CC17), seems to possess multiple determinants that increase its ability to survive and cause disease in nosocomial environments...
- Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentariumSimona Bratu
Division of Infectious Diseases, State University of New York Downstate, Brooklyn, NY 11203, USA
Arch Intern Med 165:1430-5. 2005..In this study, the prevalence and molecular epidemiologic characteristics of carbapenem-resistant K pneumoniae are analyzed, and the experience involving 2 hospital outbreaks is described...
- Epidemiology of urinary tract infections: incidence, morbidity, and economic costsBetsy Foxman
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109 2029, USA
Am J Med 113:5S-13S. 2002..Financially, the estimated annual cost of community-acquired UTI is significant, at approximately $1.6 billion...
- Clinical and economic consequences of ventilator-associated pneumonia: a systematic reviewNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Crit Care Med 33:2184-93. 2005..Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature..
- Health-care workers: source, vector, or victim of MRSA?Werner C Albrich
Respiratory and Meningeal Pathogens Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
Lancet Infect Dis 8:289-301. 2008..We discuss advantages and disadvantages of screening and eradication policies for MRSA control and give recommendations for the management of colonised health-care workers in different settings...
- Ventilator-associated pneumoniaJean Chastre
Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
Am J Respir Crit Care Med 165:867-903. 2002..Further trials will be needed to clarify the optimal duration of treatment and the circumstances in which monotherapy can be safely used...
- A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolatesJenny A Laverde Gomez
Robert Koch Institute, Infectious Diseases, Wernigerode Branch, Burgstraße 37, D 38855 Wernigerode, Germany
Int J Med Microbiol 301:165-75. 2011..faecium is increasingly prevalent...
- Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infectionMichael D Howell
Silverman Institute for Healthcare Quality and Safety, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Arch Intern Med 170:784-90. 2010..The incidence and severity of Clostridium difficile infections are increasing. Acid-suppressive therapy has been suggested as a risk factor for C difficile, but this remains controversial...
- Summer Peaks in the Incidences of Gram-Negative Bacterial Infection Among Hospitalized PatientsEli N Perencevich
Veterans Affairs Maryland Health Care System, and the Department of Epidemiology and Preventive Medicine, University of MarylandSchool of Medicine, Baltimore, Maryland 21202, USA
Infect Control Hosp Epidemiol 29:1124-31. 2008..We quantified the seasonal variation in the incidences of hospital infection caused by common bacterial pathogens and estimated the association between temperature changes and infection rates...
- Prevalence of methicillin-resistant Staphylococcus aureus colonization in residents and staff in nursing homes in Northern IrelandNaomi S Baldwin
Clinical and Practice Research Group, School of Pharmacy, Queen s University Belfast, Belfast, UK
J Am Geriatr Soc 57:620-6. 2009....
- Health-care-associated pneumonia among hospitalized patients in a Japanese community hospitalYuichiro Shindo
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
Chest 135:633-40. 2009..This study aimed to reveal the differences in mortality and pathogens between HCAP and community-acquired pneumonia (CAP) in each severity class, and to clarify the strategy for the treatment of HCAP...
- Nosocomial outbreak of a non-cefepime-susceptible ceftazidime-susceptible Pseudomonas aeruginosa strain overexpressing MexXY-OprM and producing an integron-borne PSE-1 betta-lactamaseC Pena
Hospital de Bellvitge, Barcelona, Spain
J Clin Microbiol 47:2381-7. 2009..The dominant use of a single class of antibiotics could have provided the selective pressure required for the emergence and spread of this P. aeruginosa strain...
- Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South KoreaKyungwon Lee
Yonsei University College of Medicine, Seoul, South Korea
Int J Antimicrob Agents 33:520-4. 2009..baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases...
- The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistanceD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Proc Natl Acad Sci U S A 96:1152-6. 1999..These results highlight the need for early intervention once resistance is detected...
- Inflammatory response and clinical course of adult patients with nosocomial bloodstream infections caused by Candida sppH Wisplinghoff
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
Clin Microbiol Infect 12:170-7. 2006..Clinical course and mortality in patients with Candida BSI were predicted by systemic inflammatory response and APACHE II score, but not by the infecting species...
- Attributable mortality of nosocomial candidemia, revisitedOlafur Gudlaugsson
Department of Epidemiology, University of Iowa College of Public Health, Iowa City, USA
Clin Infect Dis 37:1172-7. 2003..Nosocomial candidemia is still associated with an extremely high crude and attributable mortality--much higher than that expected from underlying disease alone...
- Population-based assessment of intensive care unit-acquired bloodstream infections in adults: Incidence, risk factors, and associated mortality rateKevin B Laupland
Division of Critical Care Medicine, University of Calgary, Calgary Health Region, Alberta, Canada
Crit Care Med 30:2462-7. 2002..The study objective was to define the incidence, risk factors, microbiology, and clinical outcomes of intensive care unit-acquired bloodstream infections...
- Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)James D Bryers; Fiscal Year: 2012..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections ..
- Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm InfantsKarel Petrak; Fiscal Year: 2009..Marketing approval for TLF to treat NIs would be of great benefit to the patients and the community, and would also be of a substantial commercial value. ..
- Advanced Nitric Oxide Release Bactericidal Urinary CathetersMark E Meyerhoff; Fiscal Year: 2013....
- Inhibitors of isoprenoid synthesis for antibacterial therapyDonald T Moir; Fiscal Year: 2013..In Phase II, we will examine analogs of the highest priority hits and chemically optimize the most promising of these structures to develop lead compounds for efficacy and toxicity testing in animal models. ..
- Vaccine Assembly from Surface Proteins of Staphylococcus AureusOlaf Schneewind; Fiscal Year: 2013..abstract_text> ..
- Biofilm Infections in Postsurgical, Trauma, and Critically Ill PatientsCarol L Wells; Fiscal Year: 2013..This project has the potential to fundamentally change our understanding of the initiation, development, and treatment of biofilm infections. ..
- EEG Synchrony, perinatal risk and outcome: analysis of CHIME dataPHILIP GEORGE GRIEVE; Fiscal Year: 2010..We will test these hypotheses with a secondary analysis of the NICHD Collaborative Home Infant Monitoring Evaluation (CHIME) data collected from 1994 to 1998. ..
- X-ray Studies of Sugar-Modifying EnzymesHazel Holden; Fiscal Year: 2013....
- Lactoferrin for Immunomodulation of Systemic Inflammatory Response SyndromeMarian L Kruzel; Fiscal Year: 2011..The goal of this proposal is to examine the utility of a novel human recombinant Lactoferrin to combat SIRS, and limit progression of SIRS. ..
- Prevention and therapy of Staphylococcus aureus infectionsOlaf Schneewind; Fiscal Year: 2010..These technologies will be developed with the goal of generating a vaccine and immune therapeutics, thereby providing protection against S. aureus infections and improving global health. ..
- Eukaryotic-type STK/STP-mediated modulation of enterococcal pathogenesisVijay Pancholi; Fiscal Year: 2010....
- Mechanisms of Pseudomonas Resistance to Membrane Permeabilization by SP-AGee W Lau; Fiscal Year: 2012..aeruginosa confers resistance/susceptibility to Surfactant Protein A may lead to new treatment strategies for life-threatening pneumonias. ..
- Innovative technologies to effectively treat Multi-drug resistant and/or biofilm-Jie Wen; Fiscal Year: 2010..By 2007, the US wound care market has grown to an estimated $10 B. This growth has driven efforts to reduce infection that resulted in the development of antimicrobial dressings. ..
- Enhancement of Dendritic Cells After Burn InjuryTracy Toliver Kinsky; Fiscal Year: 2009..These studies will determine rf enhancement of dendritic cells after severe bums can increase resistance to bum wound infection, and will determine the contribution of dendritic cells to specific immune functions. ..
- HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCCVinay M Nadkarni; Fiscal Year: 2013....
- INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMSMarcia B Goldberg; Fiscal Year: 2012..Although only eight positions per year are supported by this grant, 191 postdoctoral trainees are currently being funded by our, training program in the laboratories of the 51 participating research mentors. ..
- Understanding of a Family of Bacterial Transcription FactorsHwan Youn; Fiscal Year: 2012..The proteins can be good therapeutic targets;therefore, the knowledge gained from this study might lead to the development of an alternative therapeutic strategy to control the pathogen. ..
- Innate immune suppression following experimental injuryKRISTIN C GREATHOUSE; Fiscal Year: 2012..In addition, public health could be affected through the investigation of an immune modulating agent for the purposes of improving immune function to decrease nosocomial infection risk. ..
- HALF-PINT: Heart And Lung Failure - Pediatric INsulin Titration trial - DCCDavid Wypij; Fiscal Year: 2013....
- Design of New AntimicrobialsRobert S Hodges; Fiscal Year: 2012..S. Thus, there is an economic incentive to adopt novel antibiotics. ..
- Molecular mechanisms of C.albicans - leukocyte integrin interactionsDMITRY ALEKSANDROVICH SOLOVIEV; Fiscal Year: 2012..Data from this study are expected to highlight mechanisms which are involved in fungal-host interactions and to help design new antifungal peptides. ..
- Novel Anti-infective and Anti-thrombotic Micro-patterned Central Venous CatheterSHRAVANTHI REDDY; Fiscal Year: 2012....
- Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and ToxicantsMichael Borchers; Fiscal Year: 2010....
- Pathogenic Mechanism for Lung Infection in Mucoid PseudomonasDENNIS EDWARD OHMAN; Fiscal Year: 2013..aeruginosa infections. The results of these studies will also contribute to our overall understanding of bacterial capsule biosynthesis, which is a common mechanism of bacterial virulence for avoiding the host immune response. ..
- A Modulator of Innate Immunity for Preventing Hospital-Acquired InfectionsJames D Thacker; Fiscal Year: 2010..The product being developed in this proposal will reduce the need to use antibiotics, because it works by stimulating the phagocytic activity of the human innate immune system. ..
- Helper phage mobilization of S. aureus superantigen pathogenicity islandsGail E Christie; Fiscal Year: 2010..aureus strains and help slow the emergence of highly virulent, multiresistant organisms. ..
- Effects of glycemic control on immunityThomas P Shanley; Fiscal Year: 2012..abstract_text> ..
- A Structural Approach for Treating Drug Resistant Fungal PathogensMitchell W Mutz; Fiscal Year: 2013..4. Screen and select compounds against both C. albicans and non-albicans Candida strains. ..
- A Combination Therapy Approach to Treating Drug Resistant Fungal InfectionsMitchell W Mutz; Fiscal Year: 2011....
- Contact Network Epidemiology of Influenza and Other Nosocomial InfectionsALBERTO MARIA contact SEGRE; Fiscal Year: 2010....
- Prevention of Nosocomial Infections and Cost-Effectiveness Refined (P-NICER)Patricia W Stone; Fiscal Year: 2012..Most HAIs are preventable and it is a major public health problem. Results from this study will inform both clinicians and policy makers;these results also have the potential to improve processes at the bedside and reduce HAI rates. ..
- Preventing Nosocomial Respiratory Infections: Patient Safety in the ICUElizabeth Lee Daugherty; Fiscal Year: 2013....
- Heme Oxygenase: Structure, Function and PathogenesisAngela Wilks; Fiscal Year: 2010..These compounds will be further developed through lead optimization efforts with the goal of developing a novel class of antibiotics. ..
- Analysis of Candida albicans filamentation using SILACDEREK PAUL THOMAS; Fiscal Year: 2012..Here we propose using a phosphoproteomic approach to investigate the sensing and signalling that mediate key virulence associated events, hopefully leading to preventative strategies against these frequent nosocomial infections. ..
- Inhalable Gallium Nitrate Anti-Infective Powder for CFVu L Truong; Fiscal Year: 2010..At present, 80-95% of CF patients ultimately succumb to respiratory failure due to chronic P. aeruginosa infection and airway inflammation. ..
- Effects of Shear on Specific Adhesion Receptor Expression and Binding in the BactJames D Bryers; Fiscal Year: 2010..2. Quantify the kinetics of FNBR adhesin receptor expression on SE surfaces, as function of bacterial growth condition and prevailing fluid shear;both as planktonic and adherent cells. ..
- Function of MVFR in Pseudomonas aeruginosa virulenceLaurence G Rahme; Fiscal Year: 2010..Such targeted inhibitors could significantly enhance the long-term prognosis of burn, cystic fibrosis, and HIV patients. To this end, the results here should enable novel therapies to treat and/or prevent P. aeruginosa-human infections. ..
- Pseudomonas-Host Interactions in Cystic FibrosisBruce A Stanton; Fiscal Year: 2013..aeruginosa reduces the ability of the lung to clear infections and, ultimately, identify new therapeutic approaches to eliminate drug resistant P. aeruginosa infections. ..
- Efficacy and Mechanisms of GLN Dipeptide in the SICUThomas R Ziegler; Fiscal Year: 2012..This study is designed to delineate the clinical benefit of a major new nutrition support strategy in high-risk SICU patients ..
- Targeting a leukocyte disintegrin metalloprotease during bacterial pneumoniaBruce K Walcheck; Fiscal Year: 2013..The impact of these studies is that they will critically advance our understanding of the mechanisms of action of ADAM17 during lung infection, as well as indicate the therapeutic potential of this immune regulator. ..
- Extra-nasal Colonization and Epidemiology of Community-Associated MRSAKYLE JEANNE POPOVICH; Fiscal Year: 2013..The goal of this project is to further characterize the epidemiology and colonizaiton dynamics of CA-MRSA strains in order develop and test prevention strategies in hospital settings. ..
- Social Networks and the Spread of Influenza and other Nosocomial InfectionsPhilip M Polgreen; Fiscal Year: 2012..This work will lead to more effective infection control interventions and strategies. ..
- Vaccine Strategies for Candidal InfectionsJohn P Hennessey; Fiscal Year: 2010....
- Suppression of T cell immunity during sepsisThomas S Griffith; Fiscal Year: 2013....
- Engineering the immune response for improved resolution of Staphylococcus infectiSCOTT IRWIN SIMON; Fiscal Year: 2013..A translational goal will be implementation of a hydrogel delivery system to guide the innate immune response for improving resolution of a persistent SA infection in a mouse model of tissue injury. ..
- Small Molecule Inhibitors of P. aeruginosa Quinolone (Pqs) Quorum SensingDerek S Tan; Fiscal Year: 2013..Our long- term goals are to develop one or more advanced candidates for further preclinical and clinical evaluation as novel antibiotics to combat P. aeruginosa and potentially other pathogenic Gram-negative bacteria. ..
- Innate Immune System in Sepsis and Risks for Nosocomial InfectionsMatthew C Exline; Fiscal Year: 2013..We propose to study how sepsis weakens the body's immune system and makes these patients at risk for these secondary infections and death. Our findings may lead to new treatments for this devastating disease. ..
- Photoactivated Antimicrobial CollagenBARBARA ANN SOLTZ; Fiscal Year: 2013..The studies performed will provide important preclinical results designed to optimize materials for human clinical studies and FDA approval. ..
- Multidrug-Resistant Acinetobacter baumanniiYohei Doi; Fiscal Year: 2010..Such knowledge will help in optimizing use of existing antibiotics and improving infection control practices. ..
- Disinfectant-resistant mycobacteriaMary Jackson; Fiscal Year: 2013....
- Structural Topology of a Small Multidrug Resistant Efflux PumpNathaniel J Traaseth; Fiscal Year: 2012..The long-term goal of this project is to predict how drug binding might be altered in mutated strains of bacteria, so as to design new and better antibiotics in the event of multidrug resistance. ..
- Epicenters III: Translational Research to Prevent Healthcare Associated InfectionRichard Platt; Fiscal Year: 2013..These collaborative alliances are the culmination of productive research partnerships over many years and provide a robust response system for healthcare associated infection prevention research. ..
- Sulfur Assimilation Pathway: New Antifungal TargetsGEORGE ROBERT NEWPORT; Fiscal Year: 2010....
- Age of Blood in Children in Pediatric Intensive Care UnitsPhilip C Spinella; Fiscal Year: 2013..Positive results would also encourage research directed at understanding the mechanisms underlying the improved outcomes in children transfused RBCs of decreased storage age. ..
- Identification of a cryptic meiosis in the fungal pathogen C. albicansRACQUEL K SHERWOOD; Fiscal Year: 2010..albicans and the establishment of a meiotic pathway will open up the study of this organism to classical yeast genetic approaches. ..
- Antibiofilm/Antimicrobial Combination for Infections Associated with Vascular CatMohammad D Mansouri; Fiscal Year: 2010..Although we will only experiment this model in the laboratory and with animals at this stage, this project mainly targets hospitalized patients who depend on intravenous means to receive drugs or nutrition. ..
- Nitric Oxide Releasing Catheter Coatings to Prevent Nosocomial InfectionsNATHAN ALLAN STASKO; Fiscal Year: 2010....
- Prevention of Nosocomial Infections and Cost Effectiveness in Nursing HomesPatricia W Stone; Fiscal Year: 2013..Our interdisciplinary team is uniquely qualified to conduct this study. Results will inform bedside clinicians and policy makers across the nation on how to best eliminate HAIs in NHs and inform future guidelines. ..
- Staphylococcal biofilm and diseaseKenneth W Bayles; Fiscal Year: 2013..Ultimately, these studies will pave the way for novel therapeutic approaches for the treatment of staphylococcal infections. ..
- Acinetobacter virulence and host immunopathogenesisBrad J Spellberg; Fiscal Year: 2013..The current proposal will lay the groundwork for a future R01 focused on dissecting the molecular mechanisms of virulence in vivo at different sites of infection. ..
- Bacteriolytic phage enzymes as novel antibacterials against Yersinia pestisIan Molineux; Fiscal Year: 2009..pestis infections. These in vivo studies will parallel those involving lysins using the mouse model of plague infection. ..
- Investigations of Bacterial Biofilm Proteomes Using Artifical Amino AcidsNICHOLAS DEWAYNE BALL; Fiscal Year: 2013..By understanding these mechanisms, effective treatments can be developed to combat antibiotic resistant infections in clinical settings. ..
- Biofilm Dissemination in Staphylococcus aureusMOHAMED OMAR ELASRI; Fiscal Year: 2013..Findings from this study will lead to development of anti-biofilm therapies that will be critical to combat recalcitrant infections. ..
- Development of Infection-Resistant Suture MaterialsMatthew Phaneuf; Fiscal Year: 2004..The long-term goal, which will be completed in phase II, will be to assess this technology in vivo in order to determine infection-resistance in a wound injury model. ..
- Development of a High Efficiency Plasma SterilizerBRIAN BROSDAHL; Fiscal Year: 2007..Phygen has been awarded a contract by the US Army to develop and produce transportable sterilization devices. [unreadable] [unreadable] [unreadable]..
- Creation and validation of a lux-positive Candida strainYue Fu; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Micro-patterned surfaces for reducing the risk of catheter-associated UTISHRAVANTHI REDDY; Fiscal Year: 2009....
- Detecting Carbapenem and Quinolone Resistance in Klebsiella pneumoniae using PCR/Robert A Bonomo; Fiscal Year: 2010..pneumoniae. It is our goal that this method, based upon a novel technology, will form the basis for the implementation of real time infection control and diagnostic paradigms. ..
- Development of Infection-Resistant Suture MaterialsMatthew Phaneuf; Fiscal Year: 2007..Thus, a significant market exists for application of our technology in order to prevent wound infection. [unreadable] [unreadable] [unreadable]..
- A Better & Stable Cold High-Level Disinfectant Formulation for Medical EquipmentsRAJIV SATSANGI; Fiscal Year: 2009....
- E COLI PATHOGENICITY ISLANDSRODNEY WELCH; Fiscal Year: 1999..Coli involved in serious human diseases. This information will be of use for the development of new chemotherapeutic and vaccine strategies. ..
- Development of a Novel Composite Surgical MeshDavid J Vachon; Fiscal Year: 2012....
- Novel antibacterials targeting the 50S ribosomal subunitJoyce Sutcliffe; Fiscal Year: 2005..It is expected that these units of work will provide substantial progress toward an IND filing of a compound active against Gram-positive nosocomial pathogens. ..
- Methylerythritol Phosphate Pathway Inhibitors Targeting Gram-Negative InfectionsCHARLES TESTA; Fiscal Year: 2009....
- Coaxial Everting Membrane Catheter Bronchoalveolar LavagWilliam Krause; Fiscal Year: 2006..The proposed device will provide for the uncontaminated sampling of the lower lung aspirate for a more accurate diagnosis of the organism causing the pneumonia. [unreadable] [unreadable] [unreadable]..
- Methylerythritol Phosphate Pathway-Specific Natural Products as AntibacterialsCHARLES TESTA; Fiscal Year: 2009..The pathway is not the target of any currently prescribed therapeutic, therefore these compounds and their derivatives are expected to have prolonged utility relative to subsequent generations of antibiotics presently in use. ..
- Adrenergic Control of Stem Cell Lineage Commitment in SepsisKUZHALI MUTHUMALAIAPPAN; Fiscal Year: 2009..Since all immune cells are formed in the bone marrow from hematopoietic stem cells, we are studying the effect of catecholamine in the development and function of hematopoietic stem cells in critical burn injury. ..
- CONTROL OF ENTEROTOXIN GENE EXPRESSION IN S AUREUSGeorge Stewart; Fiscal Year: 2003..The specific role of RNAIII, the effector species first generated by the initial activation of the two component system, will be evaluated with regard to enhancement of enterotoxin gene expression. ..
- VIRUL FACTORS OF UROPATH ESCHERICHIA COLIPeter Redford; Fiscal Year: 2003....
- Impact of Fluoroquinolone resistance on Pseudomonas virulence and patient outcomeAnnie Wong Beringer; Fiscal Year: 2009....
- Local Warming: Effects on Wound Infection and HealingJoAnne Whitney; Fiscal Year: 2007..2.3. Perfusion (BF) in the surgical incision on postoperative days 3, 5 and 9 using Laser Doppler Flowmetry (LDF). ..
- Rapid sensitive low cost test for resistant microbes causing hospital infectionsSadanand Gite; Fiscal Year: 2009..The new system will enable more hospitals to implement rapid testing, which in turn leads to improved infection control and lower hospital acquired infection rates. ..
- INFECTION IN ELBW INFANTS:PROTECTION WITH MOTHER'S MILKNancy Rodriguez; Fiscal Year: 2005..Outcome measures might include whether specific immune components of OMM are recaptured in infants' urine and feces. ..
- Anti-Infective Central Venous CatheterMICHAEL VIOLANTE; Fiscal Year: 2002..Following the launch of this product into a very broad market, a number of similar intravascular devices may be released based upon the same core technology developed under this grant. ..
- Gene Expression Patterns and Lifestyles in LegionellaHoward Shuman; Fiscal Year: 2009..abstract_text> ..