encephalomyelitis

Summary

Summary: A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.

Top Publications

  1. ncbi Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia
    S AbuBakar
    Department of Medical Microbiology, University Malaya Medical Center, Kuala Lumpur, Malaysia
    Virus Res 61:1-9. 1999
  2. pmc Alphavirus-induced encephalomyelitis: antibody-secreting cells and viral clearance from the nervous system
    Talibah U Metcalf
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Virol 85:11490-501. 2011
  3. ncbi Pathologic characterization of a murine model of human enterovirus 71 encephalomyelitis
    Kien Chai Ong
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Neuropathol Exp Neurol 67:532-42. 2008
  4. pmc Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease
    Kien Chai Ong
    Department of Pathology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol 84:661-5. 2010
  5. ncbi Antiglycine-receptor encephalomyelitis with rigidity
    Natàlia Mas
    Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 82:1399-401. 2011
  6. ncbi Antibody-mediated clearance of alphavirus infection from neurons
    B Levine
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Science 254:856-60. 1991
  7. doi Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody
    M Hutchinson
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Neurology 71:1291-2. 2008
  8. ncbi Encephalomyelitis due to human parechovirus type 1
    Vincent Legay
    Centre National de Reference pour les Enterovirus et L hepatite A Laboratoire de Virologie, Domaine Rockefeller, Lyon, France
    J Clin Virol 25:193-5. 2002
  9. pmc CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis
    Cristina P Marques
    Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:6136-47. 2011
  10. pmc The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice
    Eunhye Park
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Cellular and Molecular Medicine Graduate Program, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Virology 388:305-14. 2009

Detail Information

Publications267 found, 100 shown here

  1. ncbi Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia
    S AbuBakar
    Department of Medical Microbiology, University Malaya Medical Center, Kuala Lumpur, Malaysia
    Virus Res 61:1-9. 1999
    ..an outbreak of hand, foot and mouth disease (HFMD) in Malaysia in 1997, with incidences of fatal brainstem encephalomyelitis. The isolates were identified using immunofluorescence staining, neutralization assays, and partial ..
  2. pmc Alphavirus-induced encephalomyelitis: antibody-secreting cells and viral clearance from the nervous system
    Talibah U Metcalf
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Virol 85:11490-501. 2011
    ..However, there was no evidence of germinal center activity or IgG avidity maturation within the CNS...
  3. ncbi Pathologic characterization of a murine model of human enterovirus 71 encephalomyelitis
    Kien Chai Ong
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Neuropathol Exp Neurol 67:532-42. 2008
    We describe a model of Enterovirus 71 encephalomyelitis in 2-week-old mice that shares many features with the human central nervous system (CNS) disease...
  4. pmc Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease
    Kien Chai Ong
    Department of Pathology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol 84:661-5. 2010
    ..derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were tested in a mouse model of EV71 encephalomyelitis. After only two immunizations, given to mice at 1 and 7 days of age, the MAV vaccine protected mice at 14 ..
  5. ncbi Antiglycine-receptor encephalomyelitis with rigidity
    Natàlia Mas
    Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 82:1399-401. 2011
    Glycine receptor antibodies (GlyR-ab) were reported in a patient with progressive encephalomyelitis with rigidity and myoclonus (PERM).
  6. ncbi Antibody-mediated clearance of alphavirus infection from neurons
    B Levine
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Science 254:856-60. 1991
    ..However, in a SCID mouse model of persistent alphavirus encephalomyelitis, adoptive transfer of hyperimmune serum resulted in clearance of infectious virus and viral RNA from the ..
  7. doi Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody
    M Hutchinson
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Neurology 71:1291-2. 2008
  8. ncbi Encephalomyelitis due to human parechovirus type 1
    Vincent Legay
    Centre National de Reference pour les Enterovirus et L hepatite A Laboratoire de Virologie, Domaine Rockefeller, Lyon, France
    J Clin Virol 25:193-5. 2002
    The implication of a viral agent in encephalomyelitis has been reported for several years. In the present study we wanted to demonstrate the presence of human parechovirus type 1 (HPEV1) in a patient diagnosed with encephalomyelitis.
  9. pmc CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis
    Cristina P Marques
    Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:6136-47. 2011
    ..This study demonstrates that CXCR3 mediates CNS accumulation of ASC during neurotropic coronavirus-induced encephalomyelitis. Expansion of CXCR3-expressing ASC in draining lymph nodes prior to accumulation within the CNS was ..
  10. pmc The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice
    Eunhye Park
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Cellular and Molecular Medicine Graduate Program, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Virology 388:305-14. 2009
    ..The nsP3 macro domain is important for SINV replication and age-dependent susceptibility to encephalomyelitis.
  11. pmc Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis
    Timothy W Phares
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Immunol 185:5607-18. 2010
    ..knowledge, to demonstrate that B7-H1-mediated protection from viral-induced immune pathology associated with encephalomyelitis resides in limiting T cell-mediated axonal bystander damage rather than direct elimination of infected ..
  12. pmc Progressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies
    M R Turner
    Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Neurology 77:439-43. 2011
    The syndrome of progressive encephalopathy with limb rigidity has been historically termed progressive encephalomyelitis with rigidity and myoclonus (PERM) or stiff-person syndrome plus.
  13. pmc Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis
    Shweta S Puntambekar
    Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:6702-13. 2011
    ..Moreover, a shift from predominant IL-10 production by CD25(+) CD4(+) T cells to CD25(-) CD4(+) T cells suggests that a transition to nonclassical regulatory T cells precedes and is retained during CNS viral persistence...
  14. pmc The opioid receptor antagonist, naloxone, protects spinal motor neurons in a murine model of alphavirus encephalomyelitis
    Natalie A Prow
    Department of Molecular Microbiology and Immunology, The Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Exp Neurol 205:461-70. 2007
    ..hind limb weakness in C57BL/6 mice and models the paralysis that can accompany alphavirus and flavivirus encephalomyelitis in humans...
  15. pmc Inflammatory/post-infectious encephalomyelitis
    L Bennetto
    Institute of Clinical Neurosciences, Department of Neurology, University of Bristol, Frenchay Hospital, Bristol, UK
    J Neurol Neurosurg Psychiatry 75:i22-8. 2004
  16. ncbi Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation
    Maria Heloisa Tsuhako
    Laboratorio de Imunologia Viral, Instituto Butantan, 05503 900 Sao Paulo, Brazil
    Free Radic Biol Med 48:704-12. 2010
    ..knowledge about the pathogenesis of MS has been derived from murine models, such as experimental autoimmune encephalomyelitis and viral encephalomyelitis...
  17. ncbi Acute demyelinizating encephalomyelitis (ADEM) as initial presentation of primary HIV infection
    Trine H Mogensen
    Department of Infectious Diseases, Skejby Hospital, University Hospital of Aarhus, Aarhus N, Denmark
    Scand J Infect Dis 39:630-4. 2007
    ..sexual exposure, clinical symptoms, MRI, virological and CSF findings suggestive of acute demyelinizating encephalomyelitis (ADEM) as initial presentation of primary HIV infection...
  18. ncbi Limited remyelination in Theiler's murine encephalomyelitis due to insufficient oligodendroglial differentiation of nerve/glial antigen 2 (NG2)-positive putative oligodendroglial progenitor cells
    R Ulrich
    Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg, Hannover, Germany
    Neuropathol Appl Neurobiol 34:603-20. 2008
    Limited remyelination is a key feature of demyelinating Theiler's murine encephalomyelitis (TME)...
  19. ncbi Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis
    Saravanan Kanakasabai
    Neuroscience Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    J Nutr Biochem 23:1498-507. 2012
    ..We and others have shown earlier that curcumin ameliorates experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis...
  20. ncbi Clinical signs of West Nile virus encephalomyelitis in horses during the outbreak in Israel in 2000
    A Steinman
    School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
    Vet Rec 151:47-9. 2002
    ..West Nile virus was isolated from four of the horses with encephalomyelitis and five other horses seroconverted, indicating that the virus was the probable cause of the outbreak in ..
  21. ncbi Glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus (PERM) but not in saccadic oscillations
    Takahiro Iizuka
    Department of Neurology, Kitasato University, School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    J Neurol 259:1566-73. 2012
    Glycine receptor (GlyR) antibodies were recently identified in a few patients with progressive encephalomyelitis with rigidity and myoclonus (PERM); none of these patients had antibodies against glutamic acid decarboxylase (GAD)...
  22. pmc Protection from fatal viral encephalomyelitis: AMPA receptor antagonists have a direct effect on the inflammatory response to infection
    Ivorlyne P Greene
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:3575-80. 2008
    Neuronal cell death during fatal acute viral encephalomyelitis can result from damage caused by virus replication, glutamate excitotoxicity, and the immune response...
  23. ncbi Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis
    Ludwig Hamo
    Department of Neuroscience, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Glia 55:1169-77. 2007
    ..Furthermore, prolonged MHC expression subsequent to viral clearance implies a potential for ongoing presentation...
  24. pmc Molecular basis of Sindbis virus neurovirulence in mice
    S Lustig
    Division of Biology, California Institute of Technology, Pasadena 91125
    J Virol 62:2329-36. 1988
    ..NSV causes severe encephalomyelitis with hind-limb paralysis and high mortality after intracerebral inoculation in weanling mice...
  25. pmc Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
    Yi Chen
    Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1317-26. 2006
    ..Thus, therapeutic targeting of IL-23 effectively inhibited multiple inflammatory pathways that are critical for driving CNS autoimmune inflammation...
  26. pmc A protective role for ELR+ chemokines during acute viral encephalomyelitis
    Martin P Hosking
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA
    PLoS Pathog 5:e1000648. 2009
    The functional role of ELR-positive CXC chemokines in host defense during acute viral-induced encephalomyelitis was determined...
  27. ncbi Viliuisk encephalomyelitis in Northeastern Siberia is not caused by Borrelia burgdorferi infection
    Alexander Storch
    Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Neurol Sci 29:11-4. 2008
    Viliuisk encephalomyelitis (VE) is an endemic neurological disease in Northeastern Siberia and generally believed to be a chronic encephalomyelitis of unknown origin...
  28. pmc West Nile virus encephalomyelitis in horses in Ontario: 28 cases
    J Scott Weese
    Department of Clinical Studies, Ontario Veterinary College, Guelph, Ontario N1G 2W1
    Can Vet J 44:469-73. 2003
    West Nile virus encephalomyelitis was diagnosed in 28 horses presented to the Ontario Veterinary College Veterinary Teaching Hospital between August 20 and October 15, 2002...
  29. ncbi Epidemiology of Viliuisk encephalomyelitis in Eastern Siberia
    Hee Suk Lee
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 9404, USA
    Epidemiology 21:24-30. 2010
    Viliuisk encephalomyelitis is a disorder that starts, in most cases, as an acute meningoencephalitis. Survivors of the acute phase develop a slowly progressing neurologic syndrome characterized by dementia, dysarthria, and spasticity...
  30. ncbi Pathological evidence of encephalomyelitis in the stiff man syndrome with anti-GAD antibodies
    Jason D Warren
    Department of Neurology, Royal Adelaide Hospital, and University Department of Medicine, University of Adelaide, South Australia
    J Clin Neurosci 9:328-9. 2002
    ..These findings support the notion that the SMS and progressive encephalomyelitis with rigidity (PER) form a clinical and pathologic continuum.
  31. ncbi Progressive encephalomyelitis with rigidity and myoclonus: a new variant with DPPX antibodies
    Bettina Balint
    From the Departments of Neurology B B, S J, S N, H M M and Nuclear Medicine U H, University of Heidelberg Institute for Experimental Immunology C P, I M B, R B, L K, W S, Euroimmun, Lübeck Department of Neurology A K, Klinikum Bremen Ost and Department of Neurology M K, Community Hospital Herdecke, Germany
    Neurology 82:1521-8. 2014
    To describe a novel and distinct variant of progressive encephalomyelitis with rigidity and myoclonus (PERM) associated with antibodies directed against dipeptidyl peptidase-like protein 6 (DPPX), a regulatory subunit of the Kv4...
  32. ncbi Encephalomyelitis associated with akabane virus infection in adult cows
    J K Lee
    Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Suwon, Korea
    Vet Pathol 39:269-73. 2002
    ..RT-PCR analysis revealed a target band of expected size in four cows. This is the first report on an outbreak of natural Akabane virus infection in adult cattle...
  33. pmc Viliuisk encephalomyelitis in Eastern Siberia - analysis of 390 cases
    Lev G Goldfarb
    National Institutes of Health, Room 4S06, 5625 Fishers Lane, MSC 9404, Bethesda, Maryland 20892 9404, USA
    Folia Neuropathol 47:171-81. 2009
    Viliuisk encephalomyelitis (VE) is a unique disease occurring in the Yakut (Sakha) population of Eastern Siberia...
  34. ncbi Viliuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG
    Alison J E Green
    The National CJD Surveillance Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    J Neurol Sci 212:69-73. 2003
    Viliuisk encephalomyelitis (VE) is a neurodegenerative disorder expressed as subacute meningo-encephalitis progressing to a more prolonged pan-encephalitic syndrome with a fatal outcome within 1 to 10 years...
  35. ncbi Equine herpesvirus type 1-associated myeloencephalopathy in The Netherlands: a four-year retrospective study (1999-2003)
    Lutz S Goehring
    Department of Equine Sciences, Division of Internal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Vet Intern Med 20:601-7. 2006
    ..It was concluded that breed variation, in addition to the presence of a specific EHV-1 strain, and environmental factors influence an outbreak of EHM on a premise...
  36. ncbi Neurological syndromes among horses in The Netherlands. A 5 year retrospective survey (1999-2004)
    L S Goehring
    Department of Equine Sciences, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Vet Q 27:11-20. 2005
    ..The pathogenesis of each disease is presented, followed by a description of a general presentation of the diseases as encountered under Dutch circumstances...
  37. ncbi Acute encephalomyelitis associated with acute viral hepatitis type B
    Keiko Kinomoto
    The Second Department of Internal Medicine Neurology Division, Faculty of Medical Science, University of Fukui, Japan
    Intern Med 48:241-3. 2009
    ..Magnetic resonance imaging of the brain and the spinal cord did not disclose abnormal lesions. The symptoms and clinical course were quite similar to those of acute disseminated encephalomyelitis.
  38. ncbi Detection and management of an outbreak of equine herpesvirus type 1 infection and associated neurological disease in a veterinary teaching hospital
    L S Goehring
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA
    J Vet Intern Med 24:1176-83. 2010
    ..Because of the serious disease sequelae associated with equine herpesvirus type 1 (EHV-1) infections, awareness and control measures used to control outbreaks are important issues for all horse populations...
  39. pmc Virally expressed interleukin-10 ameliorates acute encephalomyelitis and chronic demyelination in coronavirus-infected mice
    Kathryn Trandem
    Department of Microbiology, BSB 3 730, University of Iowa, Iowa City, IA 52242, USA
    J Virol 85:6822-31. 2011
    ..IL-10 functions by dampening the innate or very early T cell immune response. Further, they suggest that early treatment with IL-10 may be useful adjunct therapy in some types of viral encephalitis...
  40. pmc Japanese macaque encephalomyelitis: a spontaneous multiple sclerosis-like disease in a nonhuman primate
    Michael K Axthelm
    Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR, USA
    Ann Neurol 70:362-73. 2011
    To describe Japanese macaque encephalomyelitis (JME), a spontaneous inflammatory demyelinating disease occurring in the Oregon National Primate Research Center's (ONPRC) colony of Japanese macaques (JMs, Macaca fuscata).
  41. pmc Successful treatment of human herpesvirus 6 encephalomyelitis in immunocompetent patient
    Eric Denes
    Teaching Hospital Dupuytren, Limoges, France
    Emerg Infect Dis 10:729-31. 2004
    We report a case of human herpesvirus 6 (HHV-6) encephalomyelitis in an immunocompetent patient, which was confirmed by viral amplification from cerebrospinal fluid...
  42. ncbi HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal
    A Szabo
    Laboratory of Molecular Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 67:325-33. 1991
    A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library...
  43. ncbi Nucleocapsid or spike protein-specific CD4+ T lymphocytes protect against coronavirus-induced encephalomyelitis in the absence of CD8+ T cells
    H Korner
    Institute for Virology and Immunobiology, University of Wurzburg, F R G
    J Immunol 147:2317-23. 1991
    To investigate the antiviral CD4+ T cell response in coronavirus MHV-JHM-induced encephalomyelitis, spleen and thymic lymphocytes from diseased rats were stimulated in culture with virus Ag, expanded and tested for their specificity to ..
  44. ncbi Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas
    M Tora
    Unitat de Biologia Cel lular i Molecular, Universitat Autonoma de Barcelona, Spain
    Neurology 48:735-41. 1997
    Serum from patients with small-cell lung cancer-associated paraneoplastic encephalomyelitis/sensory neuronopathy contains autoantibodies recognizing 35- to 40-kDa nuclear antigens present in neurons, small-cell lung cancers, and some ..
  45. ncbi Progressive encephalomyelitis with rigidity and myoclonus: a syndrome with diverse clinical features and antibody responses
    Erkingül Shugaiv
    Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Eur Neurol 69:257-62. 2013
    To better characterize progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome and identify novel PERM phenotypes.
  46. pmc Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis
    Emanuele Tirotta
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697 3900, United States
    J Neuroimmunol 254:110-6. 2013
    ..These data demonstrate a regulatory role for EBI3-associated cytokines in controlling host responses following CNS viral infection...
  47. ncbi Outbreak of equine herpesvirus myeloencephalopathy in France: a clinical and molecular investigation
    S Pronost
    Frank Duncombe Laboratory, IFR 146 ICORE, University of Caen Basse Normandie, Caen Cedex, France
    Transbound Emerg Dis 59:256-63. 2012
    ..Molecular data strongly suggested taking into account any low viral load as being a potential risk factor for neurological manifestations...
  48. ncbi Progressive encephalomyelitis with rigidity and myoclonus: the first pediatric case with glycine receptor antibodies
    Joana Damasio
    Departments of Neurology, Centro Hospitalar do Porto, Porto, Portugal
    JAMA Neurol 70:498-501. 2013
    Progressive encephalomyelitis with rigidity and myoclonus is characterized by rigidity, painful muscle spasms, hyperekplexia, and brainstem signs...
  49. ncbi Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis
    F Graus
    Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain
    Neurosci Lett 112:14-8. 1990
    ..Although the Hu is also expressed by neural cells other than neurons, the strongest staining of mature neurons could indicate that Hu plays a role in the process of neuronal differentiation...
  50. ncbi Genetic and pathogenic characterization of Akabane viruses isolated from cattle with encephalomyelitis in Korea
    Jae Ku Oem
    Animal, Plant and Fisheries Quarantine and Inspection Agency, Ministry for Food, Agriculture, Forestry and Fisheries, Anyang, Republic of Korea
    Vet Microbiol 158:259-66. 2012
    A large-scale outbreak of Akabane viral encephalomyelitis in cattle was reported in the southern part of Korea in 2010...
  51. pmc Progressive encephalomyelitis with rigidity: a case report
    Ranka Baraba
    Department of Neurology, General Hospital Sveti Duh, Zagreb, Croatia
    J Spinal Cord Med 33:73-6. 2010
    The most prominent clinical features of progressive encephalomyelitis with rigidity (PER) are painful spasms and rigidity accompanied by clinical signs of brainstem and spinal cord involvement. In initial reports, PER had fatal outcome...
  52. pmc Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice
    D Sean Riminton
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
    J Exp Med 187:1517-28. 1998
    ..The contribution of LT to experimental autoimmune encephalomyelitis (EAE) was examined using TNF/LTalpha-/- mice, TNF-/- mice, and a new LTalpha-/- line described here...
  53. ncbi B cells and antibodies in the pathogenesis of myelin injury in Semliki Forest Virus encephalomyelitis
    T A Smith-Norowitz
    Department of Medicine Immunology, S U N Y Maimonides Medical Center, Brooklyn, New York 11219, USA
    Cell Immunol 200:27-35. 2000
    To determine the contribution of B cells to brain myelin injury in Semliki Forest Virus (SFV) encephalomyelitis, normal C57BL/6 (B6) and B-cell-deficient (C57BL/6-tm1Cgn) B6 mice were infected with SFV. The peak of clinical disease, i.e...
  54. ncbi [Acute disseminated encephalomyelitis (ADEM) onset during meningitis and sepsis]
    Hachiro Ohnishi
    Department of Environmental Medicine and Infectious Disease, Faculity of Medical Sciences, Kyushu University
    Kansenshogaku Zasshi 81:577-81. 2007
    ..His consciousness disturbance rapidly disappeared and brain MRI showed that the multiple high-intensity lesions had ameliorated. The patient was released after 40 days of treatment...
  55. ncbi The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways
    Kum Thong Wong
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Neuropathol Exp Neurol 67:162-9. 2008
    Previous neuropathologic studies of Enterovirus 71 encephalomyelitis have not investigated the anatomic distribution of inflammation and viral localization in the central nervous system (CNS) in detail...
  56. pmc Recruitment and retention of B cells in the central nervous system in response to alphavirus encephalomyelitis
    Talibah U Metcalf
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Virol 87:2420-9. 2013
    Sindbis virus (SINV) infection of neurons results in nonfatal viral encephalomyelitis and provides a model system for understanding recovery from virus infection of the central nervous system (CNS)...
  57. ncbi Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler's murine encephalomyelitis
    Florian Hansmann
    Department of Pathology, University of Veterinary Medicine Hannover, Bunteweg 17, 30559, Hannover, Germany
    Acta Neuropathol 124:127-42. 2012
    ..blood-brain barrier (BBB), and/or extracellular matrix remodeling in the pathogenesis of Theiler's murine encephalomyelitis (TME), a virus-induced model of MS...
  58. pmc Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats
    B P Morgan
    Complement Biology Group, Department of Medical Biochemistry and Immunology and Department of Pathology, UWCM, Cardiff, UK
    Clin Exp Immunol 138:430-8. 2004
    ..of complement activation ameliorate disease in the rat model antibody-dependent experimental autoimmune encephalomyelitis and rats unable to generate the membrane attack complex of complement develop inflammation without ..
  59. ncbi Acute disseminated encephalomyelitis associated with hepatitis A virus infection
    Füsun K Alehan
    Division of Child Neurology, Department of Paediatrics, Faculty of Medicine, Baskent University, 6 Cadde 72 3 Bahcelievler, Ankara 06490, Turkey
    Ann Trop Paediatr 24:141-4. 2004
    We describe the case of a 30-month-old boy who developed acute disseminated encephalomyelitis (ADEM) after hepatitis A virus (HAV) infection and ultimately died...
  60. pmc Factors supporting intrathecal humoral responses following viral encephalomyelitis
    Timothy W Phares
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:2589-98. 2011
    ..virus-specific ASC are crucial in controlling persistent CNS infection following coronavirus-induced encephalomyelitis. This report characterizes expression kinetics of factors associated with ASC homing, differentiation, and ..
  61. ncbi High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    J J Lafaille
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 78:399-408. 1994
    ..approximately 14% of H-2u T/R+ and 100% of H-2u T/R- mice developed spontaneous experimental autoimmune encephalomyelitis (EAE) within 12 months...
  62. ncbi Th17 Cells and autoimmune encephalomyelitis (EAE/MS)
    Toshimasa Aranami
    Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Allergol Int 57:115-20. 2008
    ..accepted that Th1 cells driven by IL-12 were pathogenic T cells in human MS and experimental autoimmune encephalomyelitis, an animal model of MS...
  63. pmc Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis
    Jessica Carmen
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Brain Res 1263:143-54. 2009
    Neuroadapted Sindbis virus (NSV) is a neuronotropic virus that causes a fulminant encephalomyelitis in susceptible mice due to death of motor neurons in the brain and spinal cord...
  64. pmc Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease
    R W Melvold
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611
    J Virol 64:686-90. 1990
    ....
  65. ncbi The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis
    M T Lin
    Department of Pathology, School of Medicine, University of Southern California, Los Angeles 90033, USA
    Virology 245:270-80. 1998
    Interleukin 10 (IL-10) is an important anti-inflammatory cytokine. To examine its role in virus-induced encephalomyelitis, IL-10-deficient (IL-10 -/-) mice were infected with a neurotropic strain of mouse hepatitis virus (JHMV)...
  66. ncbi Outcome of severe encephalomyelitis in children: effect of high-dose methylprednisolone and immunoglobulins
    Eli Shahar
    Child Neurology Unit, Meyer Children Hospital, Rambam Medical Center, Haifa, Israel
    J Child Neurol 17:810-4. 2002
    Acute encephalomyelitis in children refers to an insult of cortical white matter leading to acute disseminated encephalomyelitis, insult of the spinal cord leading to multifocal myelopathy, or a combined form of encephalomyelitis...
  67. ncbi Clinicopathological findings in dogs with distemper encephalomyelitis presented without characteristic signs of the disease
    A M Amude
    Laboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, P O Box 6001, 86051 990 Londrina, Parana, Brazil
    Res Vet Sci 82:416-22. 2007
    ..The aim of this study is to verify how the clinicopathological findings may suggest distemper encephalomyelitis in such cases...
  68. pmc Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis
    Bernhard Stamm
    Kantonsspital Aarau, Aarau, Switzerland
    Emerg Infect Dis 14:641-3. 2008
    We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. M...
  69. ncbi Clinical Sarcocystis neurona encephalomyelitis in a domestic cat following routine surgery
    J P Dubey
    Parasite Biology, Epidemiology and Systematics Laboratory, Agricultural Research Service, US Department of Agriculture, Animal and Natural Resources Institute, Beltsville Agricultural Research Center, MD 20705 2350, USA
    Vet Parasitol 112:261-7. 2003
    ..The cat was euthanized 12 days later because of paralysis. Encephalomyelitis was the only lesion and was associated with numerous Sarcocystis schizonts and merozoites in the brain and ..
  70. ncbi Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines
    Y Sekido
    Department of Internal Medicine, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235
    Cancer Res 54:4988-92. 1994
    ..HuD is the target of an immune response including high titered antibodies causing paraneoplastic encephalomyelitis and sensory neuropathy...
  71. ncbi Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene
    T W Spahn
    Center for Neurologic Diseases Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 29:4060-71. 1999
    ..with myelin oligodendrocyte glycoprotein (MOG) peptide (p) 35 - 55 induces chronic experimental autoimmune encephalomyelitis (EAE). The role of gamma delta T cells in the regulation of EAE is unclear...
  72. pmc Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    B J Steffen
    Department of Pathology, Stanford University School of Medicine, California
    Am J Pathol 145:189-201. 1994
    ..of vascular adhesion molecules during the first stage of chronic inflammation in experimental autoimmune encephalomyelitis in the SJL/J mouse...
  73. ncbi R-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: partial involvement of the CB(2
    Antonio J Sanchez
    Neuroimmunology Unit, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, San Martin de Porres 4, 28035 Madrid, Spain
    Biochem Pharmacol 72:1697-706. 2006
    ..of the non-selective cannabinoid receptor agonist WIN-2 as a suppressive drug in the experimental autoimmune encephalomyelitis (EAE) model of MS...
  74. ncbi Monocyte chemoattractant protein-1 enhances HSV-induced encephalomyelitis by stimulating Th2 responses
    H Nakajima
    Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical Branch, Galveston 77555-0435, USA
    J Leukoc Biol 70:374-80. 2001
    Monocyte chemoattractant protein (MCP)-1 has a pathogenic role in herpesvirus-induced encephalomyelitis (HSM)...
  75. pmc Family clustering of Viliuisk encephalomyelitis in traditional and new geographic regions
    Vsevolod A Vladimirtsev
    Institute of Health Sakha Yakut Republic, Yakutsk, Russian Federation
    Emerg Infect Dis 13:1321-6. 2007
    Viliuisk encephalomyelitis is an acute, often fatal, meningoencephalitis that tends to develop into a prolonged chronically progressive panencephalitis...
  76. ncbi Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS
    Linda N Stiles
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Eur J Immunol 36:613-22. 2006
    ..c.) infection of susceptible mice with mouse hepatitis virus (MHV), mice develop an acute encephalomyelitis followed by a chronic demyelinating disease...
  77. ncbi Neuronal cell death in alphavirus encephalomyelitis
    D E Griffin
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm E5132, Baltimore, MD 21205, USA
    Curr Top Microbiol Immunol 289:57-77. 2005
    ..RNA viruses that cause a spectrum of diseases in humans that include fever, rash, arthritis, meningitis, and encephalomyelitis. Sindbis virus (SINV) is the prototype alphavirus, causes encephalomyelitis in mice, and provides a model ..
  78. ncbi Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis
    William G Glass
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    J Immunol 172:4018-25. 2004
    ..of mice with mouse hepatitis virus, a member of the Coronaviridae family, reproducibly results in an acute encephalomyelitis that progresses to a chronic demyelinating disease...
  79. ncbi Acute disseminated encephalomyelitis following Plasmodium falciparum malaria caused by varicella zoster virus reactivation
    Matthias Lademann
    Department of Medicine, Division of Tropical Medicine and Infectious Diseases, University of Rostock Medical School, Rostock, Germany
    Am J Trop Med Hyg 72:478-80. 2005
    ..One to three weeks after P. falciparum malaria, acute disseminated encephalomyelitis (ADEM) can also mimick the symptoms of cerebral malaria...
  80. ncbi Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate
    Stacia Brock
    College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    Pharmacotherapy 24:673-6. 2004
    ..The diagnosis of encephalomyelitis was made on day 3 after methotrexate administration, and by day 6 mechanical ventilation was begun secondary ..
  81. ncbi MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis
    Reiner Ulrich
    Department of Pathology, University of Veterinary Medicine Hannover, Germany
    J Neuropathol Exp Neurol 65:783-93. 2006
    Theiler murine encephalomyelitis (TME) represents a highly relevant viral model for multiple sclerosis. Matrix metalloproteinases (MMPs) degrade extracellular matrix molecules and are involved in demyelination processes...
  82. ncbi Characteristics of an outbreak of West Nile virus encephalomyelitis in a previously uninfected population of horses
    Michael P Ward
    Department of Veterinary Integrative Biosciences, MS 4458, Texas A and M University, College Station, TX 77843 4458, USA
    Vet Microbiol 118:255-9. 2006
    Equine West Nile virus (WNV) encephalomyelitis cases - based on clinical signs and ELISA serology test results - reported to Texas disease control authorities during 2002 were analyzed to provide insights into the epidemiology of the ..
  83. ncbi Encephalomyelitis from West Nile flavivirus in 3 alpacas
    B Dunkel
    Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA, USA
    J Vet Intern Med 18:365-7. 2004
  84. ncbi Acute demyelinating encephalomyelitis (ADEM), cryptococcal reactivation and disseminated Herpes simplex in an HIV infected child following HAART
    Ronald van Toorn
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University and Tygerberg Children s Hospital, P O Box 19063, Tygerberg 7505, South Africa
    Eur J Paediatr Neurol 9:355-9. 2005
    ....
  85. ncbi Acute disseminated encephalomyelitis treated with plasmapheresis
    R RamachandranNair
    Department of Neurology, Medical College Hospital, Kozhikode 673008, India
    Singapore Med J 46:561-3. 2005
    Accepted modes of therapy in acute disseminated encephalomyelitis include intravenous methyl prednisolone, intravenous immunoglobulin or a combination of both...
  86. pmc Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis
    Ching G Ng
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Virol 80:10989-99. 2006
    ..Together these data indicate that the increase in susceptibility of ASM-KO mice to SV infection was the result of more-rapid replication and spread of SV in the nervous system and increased neuronal death...
  87. ncbi Induction of activator protein-1 and nuclear factor-kappaB as a prerequisite for disease development in susceptible SJL/J mice after theiler murine encephalomyelitis
    Ingo Gerhauser
    Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    J Neuropathol Exp Neurol 66:809-18. 2007
    Theiler murine encephalomyelitis (TME) represents an important mouse model of multiple sclerosis...
  88. pmc Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis
    Carine Savarin
    Department of Neurosciences, NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Virol 82:12432-40. 2008
    ..IFN-gamma reduced neutrophil accumulation and directed macrophages to white matter but did not ameliorate myelin loss...
  89. ncbi Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody
    S Perlman
    Department of Pediatrics, University of Iowa School of Medicine, Iowa City 52242
    Microb Pathog 2:185-94. 1987
    ..of maternal antibodies protected suckling C57BL/6 mice from the clinical manifestations of the acute encephalomyelitis caused by mouse hepatitis virus, strain JHM (MHV-JHM), a coronavirus, even though histological evidence of ..
  90. ncbi Optic nerve degeneration in experimental autoimmune encephalomyelitis
    John Guy
    Department of Ophthalmology, University of Florida, College of Medicine, Gainesville, FL 32610 0284, USA
    Ophthalmic Res 40:212-6. 2008
    ..of modulating antioxidant gene expression in the optic nerves of mice induced with experimental autoimmune encephalomyelitis, with a focus on long-term neuroprotection...
  91. pmc Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis
    A Lobell
    Microbiology and Tumorbiology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Exp Med 187:1543-8. 1998
    ..For this purpose we used experimental autoimmune encephalomyelitis (EAE), which is an autoaggressive disease in the central nervous system and an animal model for multiple ..
  92. ncbi Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis
    P L Poliani
    Department of Neuroscience, San Raffaele Scientific Institute-DIBIT, 20132 Milan, Italy
    Hum Gene Ther 12:905-20. 2001
    ..human interleukin 4 (IL-4) gene were protected from an hyperacute and lethal form of experimental autoimmune encephalomyelitis induced by whole myelin...
  93. ncbi Suppression of experimental allergic encephalomyelitis in rats exposed nocturnally to magnetic fields
    M A Persinger
    Behavioral Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada
    Int J Neurosci 100:107-16. 2000
    ..the rats exposed to the field displayed statistically significant suppression relative to sham-field controls (effect size = 55%) of the overt symptoms of experimental allergic encephalomyelitis which included hindleg paralyses.
  94. ncbi Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS)
    C S Constantinescu
    Department of Microbiology and Immunology, University of Leicester
    Curr Eye Res 20:71-6. 2000
    ..including multiple sclerosis (MS), also develops in a murine relapsing model of MS, experimental autoimmune encephalomyelitis (EAE) closely resembling relapsing-remitting MS, induced by immunization with myelin basic protein (MBP) in ..
  95. pmc A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination
    T E Lane
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California
    J Virol 74:1415-24. 2000
    Infection of C57BL/6 mice with mouse hepatitis virus (MHV) results in a demyelinating encephalomyelitis characterized by mononuclear cell infiltration and white matter destruction similar to the pathology of the human demyelinating ..
  96. pmc Encephalomyelitis due to Cryptococcus neoformans var gattii presenting as spinal tumour: case report and review of the literature
    P Grosse
    Department of Neurology, Charite, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol Neurosurg Psychiatry 70:113-6. 2001
    A 24 year old immunocompetent German resident is described who developed multifocal encephalomyelitis due to infection with Cryptococcus neoformans var gatti, commonly considered a disease of tropical regions...
  97. ncbi A spontaneous outbreak of Theiler's encephalomyelitis in a colony of severe combined immunodeficient mice in the UK
    N Rozengurt
    Department of Veterinary Pathology, Royal Veterinary College, London, UK
    Lab Anim 27:229-34. 1993
    ..In the present communication, we describe an outbreak of Theiler's encephalomyelitis in a colony of SCID mice which was characterized by an unusually high prevalence of clinically overt cases...
  98. ncbi DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis
    Dirk Reinhold
    Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Germany
    Front Biosci 13:2356-63. 2008
    ..In the following, we summarize the evidence for the role of both ectoenzymes in T cell activation in vitro and in vivo and provide a rationale for the use of combined or dual ectopeptidase inhibitors to treat autoimmune diseases like MS...
  99. ncbi Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis
    Karen E Malone
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Glia 56:426-35. 2008
    ....
  100. pmc The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues
    J Dalmau
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Am J Pathol 141:881-6. 1992
    ..a neuronal protein identified by the serum of patients with small cell lung cancer and paraneoplastic encephalomyelitis/sensory neuronopathy) in normal human tissues and 115 tumors of different histologic types...
  101. pmc Human herpesvirus 6 encephalomyelitis
    Jose Luis Soto-Hernandez
    Emerg Infect Dis 10:1700-2. 2004

Research Grants68

  1. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ..and regulator of innate and adaptive immune responses, and autoimmune diseases such as experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis (MS)...
  2. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..mice develop late onset spontaneous kidney autoimmunity and are more susceptible to experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  3. Neuroprotection and Myelin Repair Mechanisms in Multiple Sclerosis
    Inderjit Singh; Fiscal Year: 2013
    ..survival and differentiation of oligodendrocyte (OP) progenitor cells (OPCs) in an experimental autoimmune encephalomyelitis (EAE) model of MS...
  4. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..Experimental autoimmune encephalomyelitis (EAE) is an animal model that recapitulates many features of MS in which Th1 and Th17 cells reactive against ..
  5. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2013
    ..SV causes mild disease in humans, but has a neuronal tropism and causes encephalomyelitis in mice. The virulence of SV is age-dependent and virus-strain dependent...
  6. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    ..defined by studying the similar, albeit imperfect rodent model of MS, experimental allergic/autoimmune encephalomyelitis (EAE)...
  7. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..3high TEM cells and that Kv1.3 blockers can treat experimental autoimmune encephalomyelitis, pristane-induced arthritis, and experimental autoimmune diabetes as well as prevent delayed-type ..
  8. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..Therapy with mR- 421 profoundly suppresses experimental allergic encephalomyelitis (EAE), a classic autoimmune model system, even when treatment is initiated after disease onset...
  9. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    ..in recipient mice or rats where they suppress the inflammation observed in animal models of autoimmune encephalomyelitis, allograft rejection, collagen-induced arthritis and graft vs. host disease...
  10. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..can completely suppress the clinical disease in an experimental model of MS known as Experimental Autoimmune Encephalomyelitis (EAE)...
  11. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..Theiler's murine encephalomyelitis virus (TMEV) is a neurotropic picornavirus...
  12. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2012
    ..Sry), experience more severe autoimmune disease, namely autoimmune encephalomyelitis and pristane-induced lupus...
  13. Immune Regulation of Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2012
    ..Non of these parameters have been studied during viral or autoimmune encephalomyelitis. The ability to trace ASC and Bmem using transgenic markers provides a versatile innovative approach to ..
  14. Control of alphavirous replacation in the nervous system
    Diane E Griffin; Fiscal Year: 2013
    ..b>Encephalomyelitis due to arbovirus infection of neurons is a particularly important global cause of morbidity and mortality ..
  15. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..underlying ShK-186's therapeutic effect in chronic relapsing-remitting experimental autoimmune encephalomyelitis (CR-EAE) in DA rats, a model for human MS...
  16. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Therapy with mR-421 profoundly suppresses experimental allergic encephalomyelitis (EAE), a classic autoimmune model system, even when treatment is initiated after disease onset...
  17. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2013
    ..myelin basic protein (MBP) and proteolipid protein (PLP) can induce severe signs of experimental autoimmune encephalomyelitis (EAE) in mice that include ascending paralysis, demyelination and axonal damage...
  18. Molecular and Cellular Mechanisms of IL-17 Signaling
    Xiaoxia Li; Fiscal Year: 2013
    ..Experimental autoimmune encephalomyelitis (EAE) is widely used to dissect molecular mechanisms of MS and to develop new therapeutic strategies...
  19. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2013
    Project Summary Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are believed to be initiated by T cell-mediated immune responses to myelin antigens...
  20. Novel Functions of S1P in Neuroinflammation
    TOMASZ K KORDULA; Fiscal Year: 2013
    ..for the development and progression of multiple sclerosis (MS) in humans and experimental autoimmune encephalomyelitis (EAE) in mice...
  21. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
    ..4) Test the hypothesis that an upregulated IL15 system exacerbates experimental autoimmune encephalomyelitis (EAE), a disorder of neuroimmune modulation and a model for multiple sclerosis...
  22. Role of microRNAs in Coronavirus-induced lethal encephalitis
    Sonia Navas-Martin; Fiscal Year: 2012
    ..Different murine CoVs (Mouse Hepatitis Virus, MHV) isolates induce acute lethal encephalitis and encephalomyelitis associated with acute and chronic demyelination...
  23. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2010
    ..is to identify factors mediating ASC homing, differentiation and maintenance in the CNS following acute encephalomyelitis induced by neurotropic coronavirus...
  24. PROTEIN CARBONYLATION AND AXONAL DAMAGE IN EAE
    Oscar A Bizzozero; Fiscal Year: 2012
    ..implicated in the pathophysiology of both multiple sclerosis and its animal model, experimental allergic encephalomyelitis (EAE)...
  25. New Peptides for the Treatment of Multiple Sclerosis
    Christine Beeton; Fiscal Year: 2013
    ..inhibits delayed-type hypersensitivity, and effectively treats chronic-relapsing experimental autoimmune encephalomyelitis (CR-EAE;a model of MS) and pristane-induced arthritis...
  26. Experimental Optic Neuritis: Gene Therapy
    John Guy; Fiscal Year: 2011
    ..that detoxify reactive oxygen species (ROS) have a protective effect on suppressing experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis (MS)...
  27. SEX EFFECTS ON CHEMOKINE MEDIATED CNS AUTOIMMUNITY
    Lillian Cruz-Orengo; Fiscal Year: 2012
    ..However, specimens from patients with MS and mice with experimental autoimmune encephalomyelitis (EAE) exhibit relocation of CXCL12 to the lumenal surfaces of vessels...
  28. Viral suppression of CNS autoimmunity
    Stephen A Stohlman; Fiscal Year: 2013
    ..This infection of the murine CNS produces a nonfatal encephalomyelitis. The host's immune system clears infectious virus from the CNS but is unable to affect sterile immunity,..
  29. T CELL RESPONSE TO MYELIN PROTEOLIPID PROTEIN
    Vijay K Kuchroo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Experimental autoimmune encephalomyelitis (EAE) is an animal model that reproduces many of the clinical and pathological features of multiple sclerosis (MS)...
  30. Investigating the mechanism of TNFalpha mediated cell death in oligodendrocytes
    Junying Yuan; Fiscal Year: 2013
    ..death in vitro and two mouse models of MS in vivo [cuprizone model and experimental autoimmune encephalomyelitis model (EAE)]...
  31. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2012
    ..with the GSK3 inhibitor lithium are completely protected from development of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, and that lithium treatment after onset of clinical disease ameliorates EAE and ..
  32. Innate Regulation and CD4+Th1/17 Immunity in TMEV-Induced Demyelination
    Stephen D Miller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is widely considered the most relevant animal model of virus-induced autoimmune-mediated demyelinating ..
  33. CD-73 adenosine signaling in the central nervous system in disease and health
    Margaret S Bynoe; Fiscal Year: 2012
    ..Experimental Autoimmune Encephalomyelitis (EAE) is a mouse model for MS, and like MS, is an autoimmune disease mediated by proinflammatory immune ..
  34. Mechanism of SIRT1 activator mediated neuroprotection of retinal ganglion cells
    Kenneth S Shindler; Fiscal Year: 2013
    ..studies, we found that resveratrol attenuates RGC loss during optic neuritis in experimental autoimmune encephalomyelitis (EAE) mice, an animal model of MS...
  35. INTERFERON GAMMA EFFECTS ON OLIGODENDROCYTES
    BRIAN J POPKO; Fiscal Year: 2012
    ..role in the immune-mediated CNS disorder multiple sclerosis (MS) and its mouse model experimental autoimmune encephalomyelitis (EAE)...
  36. Novel mechanisms of immune activation following allogeneic, hematopoietic stem ce
    JOHN JAMES LETTERIO; Fiscal Year: 2013
    ..adult chimeric CDK5-/-C mice;and 4) demonstrating a resistance to the induction of experimental autoimmune encephalomyelitis in CDK5-/-C mice immunized with a MOG peptide...
  37. Mechanism of Bach1-Mediated Transcriptional Regulation and Immune Function
    David Baltimore; Fiscal Year: 2013
    ..Preliminary data demonstrated that Bach1 promotes the development of murine experimental autoimmune encephalomyelitis (EAE), which mimics human multiple sclerosis...
  38. Theiler's virus-induced aoptosis: A mechanism for CNS virus persistence
    HOWARD LEE LIPTON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Theiler's murine encephalomyelitis virus (TMEV) is a highly cytolytic RNA virus that produces persistent central nervous system (CNS) infection and immune-mediated demyelination in susceptible ..
  39. Picornavirus-host Cell Interactions and Disease
    Raymond Roos; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): DA and other members of the TO subgroup of Theiler's murine encephalomyelitis virus (TMEV) group induce a persistent infection, with a restricted virus gene expression, associated with chronic ..
  40. Theiler?s virus as a potential cause of Vilyuisk encephalitis
    HOWARD LEE LIPTON; Fiscal Year: 2010
    ..virus (VHEV), which may represent a separate clade of theilovirus, is the causative agent of Vilyuisk encephalomyelitis (VE). Although the viral cause of VE remains unknown compelling evidence links VHEV to VE...
  41. Nogo Receptors as Therapeutic Targets in a Model of Multiple Sclerosis
    BENJAMIN MATTHEW SEGAL; Fiscal Year: 2013
    ..both promote neuroinflammation and curtail neural and myelin repair in mice with experimental autoimmune encephalomyelitis (EAE), widely used as a model of MS...
  42. Lipoic Acid Therapy for Experimental Autoimmune Encephalomyelitis
    DENNIS NEIL BOURDETTE; Fiscal Year: 2013
    ..Lipoic acid is an effective therapy for the murine model of MS, experimental autoimmune encephalomyelitis (EAE), and inhibits T cell migration into the CNS in EAE...
  43. Mast cell actions in chronic progressive versus relapsing remitting EAE
    JULIANNE K HATFIELD; Fiscal Year: 2013
    ..defined by studying the similar, even if imperfect, rodent model of MS, experimental allergic/autoimmune encephalomyelitis (EAE)...
  44. Neuropeptides and Regulatory T cells
    Doina Ganea; Fiscal Year: 2013
    ..The VIP-induced DC (DCVIP) prevent collagen induced arthritis (CIA) and experimental autoimmune encephalomyelitis (EAE), stop disease progression in early stages, but do not affect innate immune cells responsible for later ..
  45. Immunomodulatory Roles of Amyloid-Beta and Amyloid Precursor Protein in CNS Autoi
    JACQUELINE LEIGH GRANT; Fiscal Year: 2012
    ..Using experimental autoimmune encephalomyelitis (EAE), an animal model of MS, I have found that in vivo administration of A[unreadable]42 attenuates ..
  46. Astrocyte dysfunction in EAE
    David N Irani; Fiscal Year: 2012
    ..parallel to the appearance and disappearance of hind limb paralysis during relapsing experimental autoimmune encephalomyelitis (EAE), an established rodent model of the human demyelinating disease, multiple sclerosis (MS)...
  47. Fatty Acid Binding Proteins in Macrophage Function
    Jill Suttles; Fiscal Year: 2013
    ..FABP-deficient mice are protected from development of experimental autoimmune encephalomyelitis (EAE)...
  48. Immunoregulation of Myelin Specific T Lymphocytes
    Arthur A Vandenbark; Fiscal Year: 2013
    ..can reverse CNS inflammation and clinical signs of MOG-peptide-induced experimental autoimmune encephalomyelitis (EAE) in DR2 transgenic mice...
  49. Role of CX3CR1 in adaptive immunity during autoimmune encephalomyelitis
    Astrid E Cardona; Fiscal Year: 2013
    ..APC) effector functions influencing the development of pathogenic T cells during experimental autoimmune encephalomyelitis (EAE)...
  50. Role of TL1A in Severity of Crohn's Disease Inflammation
    Stephan R Targan; Fiscal Year: 2013
    ..studies have also defined a critical role for TL1A in the pathogenesis of mouse experimental autoimmune encephalomyelitis (EAE), models of allergic lung inflammation and human rheumatoid arthritis...
  51. Role of LRG-47 (Irgm1) in EAE
    Shidu Yan; Fiscal Year: 2013
    ..Prominent upregulation of LRG-47 was observed in experimental autoimmune encephalomyelitis (EAE)-induced animal, which was confirmed by quantitative real-time PCR and Western blot...
  52. Protection of Mice From Lethal Alphavirus Encephalitis
    David N Irani; Fiscal Year: 2010
    ..In order to study this unique form of protection against NSV encephalomyelitis in greater detail, we propose: (1) To further characterize the beneficial effects of neuroprotective drugs ..
  53. IMMUNOMODULATION OF TRANSPLANT REJECTION BY ANTI-CD3 MAB
    Jeffrey A Bluestone; Fiscal Year: 2013
    ..The goal of this application is to test this hypothesis in mouse models of experimental autoimmune encephalomyelitis, to define the relative importance and functional stability of Tregs in different phases of disease and to ..
  54. CYTOKINES IN GLIAL CELLS AND EAE BRAIN
    Inderjit Singh; Fiscal Year: 2013
    ..statins provides immunomodulatory and blood-brain-barrier protection activities in experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  55. Reversal of T1D in NOD mice using a safe combination therapy
    Daniel Kaufman; Fiscal Year: 2013
    ..cell g-aminobutyric acid (GABA) receptors (GABA-Rs) has been shown to prevent T1D, experimental autoimmune encephalomyelitis (EAE) and rheumatoid arthritis in mouse models...
  56. p38 MAPK as a female-specific druggable target in CNS autoimmune disease
    Cory Teuscher; Fiscal Year: 2012
    ..Using experimental allergic encephalomyelitis (EAE), the principal autoimmune model of MS, we tested whether inhibition of p38 MAPK can influence EAE ..
  57. Identification of a protein that elicits immune-mediated neuronal dysfunction
    Bonnie N Dittel; Fiscal Year: 2010
    ..We have named this soluble factor Microtubule Axonal Destablizer or MAD. Using an experimental autoimmune encephalomyelitis (EAE) acute mouse model of MS, we have been able to demonstrate axonal dysfunction consistent with ..
  58. A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes Mellitus
    Kanneganti Murthy; Fiscal Year: 2013
    ..with a long-acting Fc fusion protein of CXCL11 ("mR-411") profoundly suppresses murine experimental allergic encephalomyelitis (EAE), even when initiated after disease onset...
  59. Genetic Basis for susceptibility to EAE
    Vijay K Kuchroo; Fiscal Year: 2011
    Experimental autoimmune encephalomyelitis (EAE) is an animal model for human MS that can be induced in experimental animals by immunization with myelin antigens...
  60. Function of a novel subset of dendritic cells in EAE
    Estelle Bettelli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS) characterized by inflammation and demyelination of the CNS...
  61. CB2 Receptor Regulatin of Inflammatory Response in EAE
    Ronald F Tuma; Fiscal Year: 2012
    ..Preliminary results showed that stimulation of CB2 receptors decreases CNS damage in experimental autoimmune encephalomyelitis (EAE)...
  62. Determining the compartmental role of B cell subsets during CNS autoimmunity
    Olaf Stuve; Fiscal Year: 2013
    ..generated, we will test three hypothesis regarding the role of B cell subsets in the experimental autoimmune encephalomyelitis (EAE) animal model of MS: a...
  63. 2nd International Pathogenesis of Rare Neuroimmunologic Disorders
    Douglas Kerr; Fiscal Year: 2006
    ..neuromyelitis optica (NMO), optic neuritis (ON), multiple sclerosis (MS), acute disseminated[unreadable] encephalomyelitis (ADEM), Hashimoto?s encephalitis, Rasmussen?s encephalitis, paraneoplastic[unreadable] encephalomyelitis (PE)..
  64. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..Similarly, the severity of experimental autoimmune encephalomyelitis (EAE), an MS-like disease in mice, is also diminished during pregnancy...
  65. Development of a T cell specific multiple sclerosis drug
    Arthur Vandenbark; Fiscal Year: 2005
    ..therapeutic activity in DR2 transgenic (Tg) mice with MOG-35-55 peptide induced experimental autoimmune encephalomyelitis (EAE) through mechanisms that include partial agonist signaling and cytokine switching of targeted T cells ..
  66. A novel splice variant of interleukin-13 and its role in promoting EAE responses
    Michael K Shaw; Fiscal Year: 2010
    ..shown that in mice lacking IL-13 E2 expression is highly resistant to induction of experimental autoimmune encephalomyelitis (EAE)...
  67. B7/CD28/CTLA-4 COSTIMULATION IN PATHOGENESIS OF R-EAE
    Stephen Miller; Fiscal Year: 2003
    ..on the initiation and progression of both acute and relapsing-remitting forms of experimental autoimmune encephalomyelitis (EAE), a CD4+ T-cell-mediated autoimmune disease which serves as a model for multiple sclerosis...
  68. Protective Effect of Pregnancy Doses of Estrogens in EAE
    Rhonda Voskuhl; Fiscal Year: 2005
    ..In murine experimental autoimmune encephalomyelitis (EAE), estrogen treatment has been shown to cause a favorable shift in cytokine profile with an increase in ..