encephalomyelitis

Summary

Summary: A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.

Top Publications

  1. ncbi Effect of intermittent oral administration of ponazuril on experimental Sarcocystis neurona infection of horses
    Robert J MacKay
    Department of Large Animal Clinical Sciences, University of Florida, Gainesville, FL 32610, USA
    Am J Vet Res 69:396-402. 2008
  2. ncbi Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease
    Kien Chai Ong
    Department of Pathology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol 84:661-5. 2010
  3. ncbi High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    J J Lafaille
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 78:399-408. 1994
  4. ncbi Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis
    Ludwig Hamo
    Department of Neuroscience, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Glia 55:1169-77. 2007
  5. ncbi Factors supporting intrathecal humoral responses following viral encephalomyelitis
    Timothy W Phares
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:2589-98. 2011
  6. ncbi Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis
    Bernhard Stamm
    Kantonsspital Aarau, Aarau, Switzerland
    Emerg Infect Dis 14:641-3. 2008
  7. ncbi Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    B J Steffen
    Department of Pathology, Stanford University School of Medicine, California
    Am J Pathol 145:189-201. 1994
  8. ncbi Th17 Cells and autoimmune encephalomyelitis (EAE/MS)
    Toshimasa Aranami
    Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Allergol Int 57:115-20. 2008
  9. ncbi The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways
    Kum Thong Wong
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Neuropathol Exp Neurol 67:162-9. 2008
  10. ncbi CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis
    Cristina P Marques
    Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:6136-47. 2011

Research Grants

  1. 2nd International Pathogenesis of Rare Neuroimmunologic Disorders
    Douglas Kerr; Fiscal Year: 2006
  2. CD-73 adenosine signaling in the central nervous system in disease and health
    MARGARET BYNOE; Fiscal Year: 2009
  3. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2010
  4. ACUTE ALPHAVIRUAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2007
  5. CD-73 adenosine signaling in the central nervous system in disease and health
    Margaret S Bynoe; Fiscal Year: 2010
  6. CD-73 adenosine signaling in the central nervous system in disease and health
    Margaret S Bynoe; Fiscal Year: 2010
  7. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
  8. Phytoestrogens as an alternative treatment for MS
    Bruce Bebo; Fiscal Year: 2005
  9. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
  10. Development of a T cell specific multiple sclerosis drug
    Arthur Vandenbark; Fiscal Year: 2005

Detail Information

Publications235 found, 100 shown here

  1. ncbi Effect of intermittent oral administration of ponazuril on experimental Sarcocystis neurona infection of horses
    Robert J MacKay
    Department of Large Animal Clinical Sciences, University of Florida, Gainesville, FL 32610, USA
    Am J Vet Res 69:396-402. 2008
    ..To evaluate the effect of intermittent oral administration of ponazuril on immunoconversion against Sarcocystis neurona in horses inoculated intragastrically with S neurona sporocysts...
  2. ncbi Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease
    Kien Chai Ong
    Department of Pathology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol 84:661-5. 2010
    ..derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were tested in a mouse model of EV71 encephalomyelitis. After only two immunizations, given to mice at 1 and 7 days of age, the MAV vaccine protected mice at 14 ..
  3. ncbi High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    J J Lafaille
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 78:399-408. 1994
    ..approximately 14% of H-2u T/R+ and 100% of H-2u T/R- mice developed spontaneous experimental autoimmune encephalomyelitis (EAE) within 12 months...
  4. ncbi Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis
    Ludwig Hamo
    Department of Neuroscience, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Glia 55:1169-77. 2007
    ..Furthermore, prolonged MHC expression subsequent to viral clearance implies a potential for ongoing presentation...
  5. ncbi Factors supporting intrathecal humoral responses following viral encephalomyelitis
    Timothy W Phares
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:2589-98. 2011
    ..virus-specific ASC are crucial in controlling persistent CNS infection following coronavirus-induced encephalomyelitis. This report characterizes expression kinetics of factors associated with ASC homing, differentiation, and ..
  6. ncbi Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis
    Bernhard Stamm
    Kantonsspital Aarau, Aarau, Switzerland
    Emerg Infect Dis 14:641-3. 2008
    We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. M...
  7. ncbi Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    B J Steffen
    Department of Pathology, Stanford University School of Medicine, California
    Am J Pathol 145:189-201. 1994
    ..of vascular adhesion molecules during the first stage of chronic inflammation in experimental autoimmune encephalomyelitis in the SJL/J mouse...
  8. ncbi Th17 Cells and autoimmune encephalomyelitis (EAE/MS)
    Toshimasa Aranami
    Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Allergol Int 57:115-20. 2008
    ..accepted that Th1 cells driven by IL-12 were pathogenic T cells in human MS and experimental autoimmune encephalomyelitis, an animal model of MS...
  9. ncbi The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways
    Kum Thong Wong
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Neuropathol Exp Neurol 67:162-9. 2008
    Previous neuropathologic studies of Enterovirus 71 encephalomyelitis have not investigated the anatomic distribution of inflammation and viral localization in the central nervous system (CNS) in detail...
  10. ncbi CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis
    Cristina P Marques
    Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:6136-47. 2011
    ..This study demonstrates that CXCR3 mediates CNS accumulation of ASC during neurotropic coronavirus-induced encephalomyelitis. Expansion of CXCR3-expressing ASC in draining lymph nodes prior to accumulation within the CNS was ..
  11. ncbi Progressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies
    M R Turner
    Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Neurology 77:439-43. 2011
    The syndrome of progressive encephalopathy with limb rigidity has been historically termed progressive encephalomyelitis with rigidity and myoclonus (PERM) or stiff-person syndrome plus.
  12. ncbi Pathologic characterization of a murine model of human enterovirus 71 encephalomyelitis
    Kien Chai Ong
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Neuropathol Exp Neurol 67:532-42. 2008
    We describe a model of Enterovirus 71 encephalomyelitis in 2-week-old mice that shares many features with the human central nervous system (CNS) disease...
  13. ncbi Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats
    B P Morgan
    Complement Biology Group, Department of Medical Biochemistry and Immunology and Department of Pathology, UWCM, Cardiff, UK
    Clin Exp Immunol 138:430-8. 2004
    ..of complement activation ameliorate disease in the rat model antibody-dependent experimental autoimmune encephalomyelitis and rats unable to generate the membrane attack complex of complement develop inflammation without ..
  14. ncbi Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis
    Jessica Carmen
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Brain Res 1263:143-54. 2009
    Neuroadapted Sindbis virus (NSV) is a neuronotropic virus that causes a fulminant encephalomyelitis in susceptible mice due to death of motor neurons in the brain and spinal cord...
  15. ncbi Clinicopathological findings in dogs with distemper encephalomyelitis presented without characteristic signs of the disease
    A M Amude
    Laboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, P O Box 6001, 86051 990 Londrina, Parana, Brazil
    Res Vet Sci 82:416-22. 2007
    ..The aim of this study is to verify how the clinicopathological findings may suggest distemper encephalomyelitis in such cases...
  16. ncbi Antiglycine-receptor encephalomyelitis with rigidity
    Natàlia Mas
    Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 82:1399-401. 2011
    Glycine receptor antibodies (GlyR-ab) were reported in a patient with progressive encephalomyelitis with rigidity and myoclonus (PERM).
  17. ncbi Protection from fatal viral encephalomyelitis: AMPA receptor antagonists have a direct effect on the inflammatory response to infection
    Ivorlyne P Greene
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:3575-80. 2008
    Neuronal cell death during fatal acute viral encephalomyelitis can result from damage caused by virus replication, glutamate excitotoxicity, and the immune response...
  18. ncbi Acute disseminated encephalomyelitis associated with hepatitis A virus infection
    Füsun K Alehan
    Division of Child Neurology, Department of Paediatrics, Faculty of Medicine, Baskent University, 6 Cadde 72 3 Bahcelievler, Ankara 06490, Turkey
    Ann Trop Paediatr 24:141-4. 2004
    We describe the case of a 30-month-old boy who developed acute disseminated encephalomyelitis (ADEM) after hepatitis A virus (HAV) infection and ultimately died...
  19. ncbi Alphavirus-induced encephalomyelitis: antibody-secreting cells and viral clearance from the nervous system
    Talibah U Metcalf
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Virol 85:11490-501. 2011
    ..However, there was no evidence of germinal center activity or IgG avidity maturation within the CNS...
  20. ncbi Clinical Sarcocystis neurona encephalomyelitis in a domestic cat following routine surgery
    J P Dubey
    Parasite Biology, Epidemiology and Systematics Laboratory, Agricultural Research Service, US Department of Agriculture, Animal and Natural Resources Institute, Beltsville Agricultural Research Center, MD 20705 2350, USA
    Vet Parasitol 112:261-7. 2003
    ..The cat was euthanized 12 days later because of paralysis. Encephalomyelitis was the only lesion and was associated with numerous Sarcocystis schizonts and merozoites in the brain and ..
  21. ncbi The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis
    M T Lin
    Department of Pathology, School of Medicine, University of Southern California, Los Angeles 90033, USA
    Virology 245:270-80. 1998
    Interleukin 10 (IL-10) is an important anti-inflammatory cytokine. To examine its role in virus-induced encephalomyelitis, IL-10-deficient (IL-10 -/-) mice were infected with a neurotropic strain of mouse hepatitis virus (JHMV)...
  22. ncbi Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene
    T W Spahn
    Center for Neurologic Diseases Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 29:4060-71. 1999
    ..with myelin oligodendrocyte glycoprotein (MOG) peptide (p) 35 - 55 induces chronic experimental autoimmune encephalomyelitis (EAE). The role of gamma delta T cells in the regulation of EAE is unclear...
  23. ncbi Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines
    Y Sekido
    Department of Internal Medicine, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235
    Cancer Res 54:4988-92. 1994
    ..HuD is the target of an immune response including high titered antibodies causing paraneoplastic encephalomyelitis and sensory neuropathy...
  24. ncbi Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody
    M Hutchinson
    Department of Neurology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland
    Neurology 71:1291-2. 2008
  25. ncbi R-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: partial involvement of the CB(2
    Antonio J Sanchez
    Neuroimmunology Unit, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, San Martin de Porres 4, 28035 Madrid, Spain
    Biochem Pharmacol 72:1697-706. 2006
    ..of the non-selective cannabinoid receptor agonist WIN-2 as a suppressive drug in the experimental autoimmune encephalomyelitis (EAE) model of MS...
  26. ncbi HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal
    A Szabo
    Laboratory of Molecular Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 67:325-33. 1991
    A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library...
  27. ncbi Family clustering of Viliuisk encephalomyelitis in traditional and new geographic regions
    Vsevolod A Vladimirtsev
    Institute of Health Sakha Yakut Republic, Yakutsk, Russian Federation
    Emerg Infect Dis 13:1321-6. 2007
    Viliuisk encephalomyelitis is an acute, often fatal, meningoencephalitis that tends to develop into a prolonged chronically progressive panencephalitis...
  28. ncbi Monocyte chemoattractant protein-1 enhances HSV-induced encephalomyelitis by stimulating Th2 responses
    H Nakajima
    Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical Branch, Galveston 77555-0435, USA
    J Leukoc Biol 70:374-80. 2001
    Monocyte chemoattractant protein (MCP)-1 has a pathogenic role in herpesvirus-induced encephalomyelitis (HSM)...
  29. ncbi Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
    Yi Chen
    Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1317-26. 2006
    ..Thus, therapeutic targeting of IL-23 effectively inhibited multiple inflammatory pathways that are critical for driving CNS autoimmune inflammation...
  30. ncbi A protective role for ELR+ chemokines during acute viral encephalomyelitis
    Martin P Hosking
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA
    PLoS Pathog 5:e1000648. 2009
    The functional role of ELR-positive CXC chemokines in host defense during acute viral-induced encephalomyelitis was determined...
  31. ncbi Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS
    Linda N Stiles
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Eur J Immunol 36:613-22. 2006
    ..c.) infection of susceptible mice with mouse hepatitis virus (MHV), mice develop an acute encephalomyelitis followed by a chronic demyelinating disease...
  32. ncbi A spontaneous outbreak of Theiler's encephalomyelitis in a colony of severe combined immunodeficient mice in the UK
    N Rozengurt
    Department of Veterinary Pathology, Royal Veterinary College, London, UK
    Lab Anim 27:229-34. 1993
    ..In the present communication, we describe an outbreak of Theiler's encephalomyelitis in a colony of SCID mice which was characterized by an unusually high prevalence of clinically overt cases...
  33. ncbi Acute disseminated encephalomyelitis treated with plasmapheresis
    R RamachandranNair
    Department of Neurology, Medical College Hospital, Kozhikode 673008, India
    Singapore Med J 46:561-3. 2005
    Accepted modes of therapy in acute disseminated encephalomyelitis include intravenous methyl prednisolone, intravenous immunoglobulin or a combination of both...
  34. ncbi Encephalomyelitis due to Cryptococcus neoformans var gattii presenting as spinal tumour: case report and review of the literature
    P Grosse
    Department of Neurology, Charite, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol Neurosurg Psychiatry 70:113-6. 2001
    A 24 year old immunocompetent German resident is described who developed multifocal encephalomyelitis due to infection with Cryptococcus neoformans var gatti, commonly considered a disease of tropical regions...
  35. ncbi Characteristics of an outbreak of West Nile virus encephalomyelitis in a previously uninfected population of horses
    Michael P Ward
    Department of Veterinary Integrative Biosciences, MS 4458, Texas A and M University, College Station, TX 77843 4458, USA
    Vet Microbiol 118:255-9. 2006
    Equine West Nile virus (WNV) encephalomyelitis cases - based on clinical signs and ELISA serology test results - reported to Texas disease control authorities during 2002 were analyzed to provide insights into the epidemiology of the ..
  36. ncbi The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues
    J Dalmau
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Am J Pathol 141:881-6. 1992
    ..a neuronal protein identified by the serum of patients with small cell lung cancer and paraneoplastic encephalomyelitis/sensory neuronopathy) in normal human tissues and 115 tumors of different histologic types...
  37. ncbi Encephalomyelitis associated with akabane virus infection in adult cows
    J K Lee
    Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Suwon, Korea
    Vet Pathol 39:269-73. 2002
    ..RT-PCR analysis revealed a target band of expected size in four cows. This is the first report on an outbreak of natural Akabane virus infection in adult cattle...
  38. ncbi Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis
    P L Poliani
    Department of Neuroscience, San Raffaele Scientific Institute-DIBIT, 20132 Milan, Italy
    Hum Gene Ther 12:905-20. 2001
    ..human interleukin 4 (IL-4) gene were protected from an hyperacute and lethal form of experimental autoimmune encephalomyelitis induced by whole myelin...
  39. ncbi Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis
    Carine Savarin
    Department of Neurosciences, NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Virol 82:12432-40. 2008
    ..IFN-gamma reduced neutrophil accumulation and directed macrophages to white matter but did not ameliorate myelin loss...
  40. ncbi Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis
    Ching G Ng
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Virol 80:10989-99. 2006
    ..Together these data indicate that the increase in susceptibility of ASM-KO mice to SV infection was the result of more-rapid replication and spread of SV in the nervous system and increased neuronal death...
  41. ncbi MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis
    Reiner Ulrich
    Department of Pathology, University of Veterinary Medicine Hannover, Germany
    J Neuropathol Exp Neurol 65:783-93. 2006
    Theiler murine encephalomyelitis (TME) represents a highly relevant viral model for multiple sclerosis. Matrix metalloproteinases (MMPs) degrade extracellular matrix molecules and are involved in demyelination processes...
  42. ncbi A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination
    T E Lane
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California
    J Virol 74:1415-24. 2000
    Infection of C57BL/6 mice with mouse hepatitis virus (MHV) results in a demyelinating encephalomyelitis characterized by mononuclear cell infiltration and white matter destruction similar to the pathology of the human demyelinating ..
  43. ncbi Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS)
    C S Constantinescu
    Department of Microbiology and Immunology, University of Leicester
    Curr Eye Res 20:71-6. 2000
    ..including multiple sclerosis (MS), also develops in a murine relapsing model of MS, experimental autoimmune encephalomyelitis (EAE) closely resembling relapsing-remitting MS, induced by immunization with myelin basic protein (MBP) in ..
  44. ncbi Encephalomyelitis from West Nile flavivirus in 3 alpacas
    B Dunkel
    Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA, USA
    J Vet Intern Med 18:365-7. 2004
  45. ncbi Inflammatory/post-infectious encephalomyelitis
    L Bennetto
    Institute of Clinical Neurosciences, Department of Neurology, University of Bristol, Frenchay Hospital, Bristol, UK
    J Neurol Neurosurg Psychiatry 75:i22-8. 2004
  46. ncbi Neuronal cell death in alphavirus encephalomyelitis
    D E Griffin
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm E5132, Baltimore, MD 21205, USA
    Curr Top Microbiol Immunol 289:57-77. 2005
    ..RNA viruses that cause a spectrum of diseases in humans that include fever, rash, arthritis, meningitis, and encephalomyelitis. Sindbis virus (SINV) is the prototype alphavirus, causes encephalomyelitis in mice, and provides a model ..
  47. ncbi Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis
    William G Glass
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    J Immunol 172:4018-25. 2004
    ..of mice with mouse hepatitis virus, a member of the Coronaviridae family, reproducibly results in an acute encephalomyelitis that progresses to a chronic demyelinating disease...
  48. ncbi Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis
    Karen E Malone
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Glia 56:426-35. 2008
    ....
  49. ncbi Acute disseminated encephalomyelitis following Plasmodium falciparum malaria caused by varicella zoster virus reactivation
    Matthias Lademann
    Department of Medicine, Division of Tropical Medicine and Infectious Diseases, University of Rostock Medical School, Rostock, Germany
    Am J Trop Med Hyg 72:478-80. 2005
    ..One to three weeks after P. falciparum malaria, acute disseminated encephalomyelitis (ADEM) can also mimick the symptoms of cerebral malaria...
  50. ncbi Viliuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG
    Alison J E Green
    The National CJD Surveillance Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    J Neurol Sci 212:69-73. 2003
    Viliuisk encephalomyelitis (VE) is a neurodegenerative disorder expressed as subacute meningo-encephalitis progressing to a more prolonged pan-encephalitic syndrome with a fatal outcome within 1 to 10 years...
  51. ncbi Encephalomyelitis due to human parechovirus type 1
    Vincent Legay
    Centre National de Reference pour les Enterovirus et L'hepatite A Laboratoire de Virologie, Domaine Rockefeller, Lyon, France
    J Clin Virol 25:193-5. 2002
    OBJECTIVES: The implication of a viral agent in encephalomyelitis has been reported for several years...
  52. ncbi Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis
    A Lobell
    Microbiology and Tumorbiology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Exp Med 187:1543-8. 1998
    ..For this purpose we used experimental autoimmune encephalomyelitis (EAE), which is an autoaggressive disease in the central nervous system and an animal model for multiple ..
  53. ncbi Optic nerve degeneration in experimental autoimmune encephalomyelitis
    John Guy
    Department of Ophthalmology, University of Florida, College of Medicine, Gainesville, FL 32610 0284, USA
    Ophthalmic Res 40:212-6. 2008
    ..of modulating antioxidant gene expression in the optic nerves of mice induced with experimental autoimmune encephalomyelitis, with a focus on long-term neuroprotection...
  54. ncbi DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis
    Dirk Reinhold
    Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Germany
    Front Biosci 13:2356-63. 2008
    ..In the following, we summarize the evidence for the role of both ectoenzymes in T cell activation in vitro and in vivo and provide a rationale for the use of combined or dual ectopeptidase inhibitors to treat autoimmune diseases like MS...
  55. ncbi Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody
    S Perlman
    Department of Pediatrics, University of Iowa School of Medicine, Iowa City 52242
    Microb Pathog 2:185-94. 1987
    ..of maternal antibodies protected suckling C57BL/6 mice from the clinical manifestations of the acute encephalomyelitis caused by mouse hepatitis virus, strain JHM (MHV-JHM), a coronavirus, even though histological evidence of ..
  56. ncbi Acute demyelinating encephalomyelitis (ADEM), cryptococcal reactivation and disseminated Herpes simplex in an HIV infected child following HAART
    Ronald van Toorn
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University and Tygerberg Children s Hospital, P O Box 19063, Tygerberg 7505, South Africa
    Eur J Paediatr Neurol 9:355-9. 2005
    ....
  57. ncbi Induction of activator protein-1 and nuclear factor-kappaB as a prerequisite for disease development in susceptible SJL/J mice after theiler murine encephalomyelitis
    Ingo Gerhauser
    Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    J Neuropathol Exp Neurol 66:809-18. 2007
    Theiler murine encephalomyelitis (TME) represents an important mouse model of multiple sclerosis...
  58. ncbi Suppression of experimental allergic encephalomyelitis in rats exposed nocturnally to magnetic fields
    M A Persinger
    Behavioral Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada
    Int J Neurosci 100:107-16. 2000
    ..the rats exposed to the field displayed statistically significant suppression relative to sham-field controls (effect size = 55%) of the overt symptoms of experimental allergic encephalomyelitis which included hindleg paralyses.
  59. ncbi Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate
    Stacia Brock
    College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    Pharmacotherapy 24:673-6. 2004
    ..The diagnosis of encephalomyelitis was made on day 3 after methotrexate administration, and by day 6 mechanical ventilation was begun secondary ..
  60. ncbi Human herpesvirus 6 encephalomyelitis
    Jose Luis Soto-Hernandez
    Emerg Infect Dis 10:1700-2. 2004
  61. ncbi Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice
    D Sean Riminton
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
    J Exp Med 187:1517-28. 1998
    ..The contribution of LT to experimental autoimmune encephalomyelitis (EAE) was examined using TNF/LTalpha-/- mice, TNF-/- mice, and a new LTalpha-/- line described here...
  62. ncbi Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia
    S AbuBakar
    Department of Medical Microbiology, University Malaya Medical Center, Kuala Lumpur, Malaysia
    Virus Res 61:1-9. 1999
    ..an outbreak of hand, foot and mouth disease (HFMD) in Malaysia in 1997, with incidences of fatal brainstem encephalomyelitis. The isolates were identified using immunofluorescence staining, neutralization assays, and partial ..
  63. ncbi Bilateral anterior optic neuritis in adult measles infection without encephalomyelitis
    Masami Azuma
    Kyorin Eye Center, Kyorin University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 134:768-9. 2002
    ..A fall in serum IgM and a rise in serum IgG titers were observed. CONCLUSIONS: Although rare, optic neuritis in the absence of encephalomyelitis may occur in measles. Whether treatment is effective is unknown.
  64. ncbi An immunodominant CD4+ T cell site on the nucleocapsid protein of murine coronavirus contributes to protection against encephalomyelitis
    H Wege
    Institute of Virology and Immunobiology, University of Wurzburg, Germany
    J Gen Virol 74:1287-94. 1993
    ..By contrast, all truncated N protein fragments elicited a humoral immune response and contained antigenic sites recognized by antibodies from diseased rats...
  65. ncbi Acute demyelinating encephalomyelitis (ADEM) in a patient with HIV infection
    S H Allen
    Department of HIV Medicine, Royal Free Hospital, Hampstead, London, UK
    J Infect 45:62-4. 2002
    A case of acute demyelinating encephalomyelitis (ADEM) in a patient with HIV infection is reported...
  66. ncbi Clinical signs of West Nile virus encephalomyelitis in horses during the outbreak in Israel in 2000
    A Steinman
    School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
    Vet Rec 151:47-9. 2002
    ..West Nile virus was isolated from four of the horses with encephalomyelitis and five other horses seroconverted, indicating that the virus was the probable cause of the outbreak in ..
  67. ncbi Acute demyelinizating encephalomyelitis (ADEM) as initial presentation of primary HIV infection
    Trine H Mogensen
    Department of Infectious Diseases, Skejby Hospital, University Hospital of Aarhus, Aarhus N, Denmark
    Scand J Infect Dis 39:630-4. 2007
    ..sexual exposure, clinical symptoms, MRI, virological and CSF findings suggestive of acute demyelinizating encephalomyelitis (ADEM) as initial presentation of primary HIV infection...
  68. ncbi [Two cases of acute disseminated encephalomyelitis with lesions in the thalamus or basal ganglia on MRI]
    A Okumura
    Department of Pediatrics, Nagoya University School of Medicine
    No To Hattatsu 24:278-82. 1992
    Lesions in the thalamus or basal ganglia have rarely been reported in acute disseminated encephalomyelitis (ADEM). We experienced 2 cases of ADEM, in which MRI showed lesions in the thalamus or basal ganglia...
  69. ncbi Early migration of Sarcocystis neurona in ponies fed sporocysts
    E Elitsur
    Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1092, USA
    J Parasitol 93:1222-5. 2007
    ..Microscopic lesions consistent with an EPM infection were observed in brain and spinal cord of ponies killed 7 and 9 days PI. Results suggest that S. neurona disseminates quickly in tissue of naive ponies...
  70. ncbi An equine protozoal myeloencephalitis challenge model testing a second transport after inoculation with Sarcocystis neurona sporocysts
    W J A Saville
    Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1092, USA
    J Parasitol 90:1406-10. 2004
    ..This model results in consistent, significant clinical signs in all horses at approximately the same time period after inoculation but was most severe in horses that did not experience a second transport...
  71. ncbi Effect of a single dose of ponazuril on neural infection and clinical disease in Sarcocystis neurona-challenged interferon-gamma knockout mice
    Robert P Franklin
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Ave, Gainesville, FL 32610, USA
    Vet Parasitol 114:123-30. 2003
    ..These results indicate that single-dose administration of ponazuril for prevention of CNS infection is partially protective when given between days 4 and 14 pi...
  72. ncbi A multicenter case-control study of risk factors for equine protozoal myeloencephalitis
    Noah D Cohen
    Department of Large Animal Clinical Sciences, College of Science, Texas A and M University, College Station, TX 77843 4475, USA
    J Am Vet Med Assoc 231:1857-63. 2007
    ..To identify risk factors for equine protozoal myeloencephalitis (EPM) among horses examined at 11 equine referral hospitals...
  73. ncbi Epidemiology of Sarcocystis neurona infections in domestic cats (Felis domesticus) and its association with equine protozoal myeloencephalitis (EPM) case farms and feral cats from a mobile spay and neuter clinic
    J F Stanek
    Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210-1092, USA
    Vet Parasitol 117:239-49. 2003
    ..neurona and serve as one of several natural intermediate hosts for S. neurona...
  74. ncbi Outbreak of equine herpesvirus type 1 myeloencephalitis: new insights from virus identification by PCR and the application of an EHV-1-specific antibody detection ELISA
    M J Studdert
    Centre for Equine Virology, School of Veterinary Science, University of Melbourne, Parkville 3010, Australia
    Vet Rec 153:417-23. 2003
    ..In contrast, sera from the five unaffected in-contact mares were all EHV-1-antibody positive when they were first tested seven or 13 days after the index case...
  75. ncbi West Nile virus encephalomyelitis in horses in Ontario: 28 cases
    J Scott Weese
    Department of Clinical Studies, Ontario Veterinary College, Guelph, Ontario N1G 2W1
    Can Vet J 44:469-73. 2003
    West Nile virus encephalomyelitis was diagnosed in 28 horses presented to the Ontario Veterinary College Veterinary Teaching Hospital between August 20 and October 15, 2002...
  76. ncbi First case report of Sarcocystis neurona-induced equine protozoal myeloencephalitis in Japan
    Yoshinari Katayama
    Epizootic Research Station, Equine Research Institute, Japan Racing Association, Tochigi, Japan
    J Vet Med Sci 65:757-9. 2003
    ..neurona) antiserum. S. neurona-specific antibodies were detected in the serum and cerebrospinal fluid by Western blot. This is the first equine protozoal myeloencephalitis case in Japan...
  77. ncbi Assessing the agreement of Western blot test results for paired serum and cerebrospinal fluid samples from horses tested for antibodies to Sarcocystis neuronaf
    M G Rossano
    The Population Medicine Center, A 59 Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Vet Parasitol 115:233-8. 2003
    ..Our results demonstrate that the level of agreement is only moderate in diagnostic samples. This supports the practice of testing CSF of seropositive horses suspected of having EPM...
  78. ncbi Genetic variation among isolates of Sarcocystis neurona, the agent of protozoal myeloencephalitis, as revealed by amplified fragment length polymorphism markers
    H M Elsheikha
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA
    Infect Immun 74:3448-54. 2006
    ..neurona and its closest relatives, allowing them to be clustered by relative similarity using band matching and unweighted pair group method with arithmetic mean analysis, which may be applicable to other related protozoal species...
  79. ncbi Assessment of Sarcocystis neurona sporocyst viability and differentiation between viable and nonviable sporocysts using propidium iodide stain
    Hany M Elsheikha
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    J Parasitol 90:872-5. 2004
    ..These results suggest that the PI dye-exclusion technique can be a useful tool in identifying viability and potential infectivity of S. neurona sporocysts and in differentiating between viable and nonviable sporocysts...
  80. ncbi Risk of transplacental transmission of Sarcocystis neurona and Neospora hughesi in California horses
    Paulo C Duarte
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, California 95616, USA
    J Parasitol 90:1345-51. 2004
    ..2%. In conclusion, there was no detectable risk of transplacental transmission of S. neurona and N. hughesi. Prevalence of antibodies against both parasites in mares increased with age...
  81. ncbi Antigenic evaluation of a recombinant baculovirus-expressed Sarcocystis neurona SAG1 antigen
    G D Gupta
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Parasitol 90:1027-33. 2004
    ..This is the first report of a baculovirus-expressed recombinant S. neurona antigen being used to detect anti-S. neurona antibodies in a variety of host species...
  82. ncbi Prevalence of agglutinating antibodies to Sarcocystis neurona in raccoons (Procyon lotor) from an urban area of Virginia
    Katie Hancock
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, 1410 Prices Fork Road, Blacksburg, Virginia 24061-0342, USA
    J Parasitol 90:881-2. 2004
    ..C. Samples from 469 raccoons were examined, and agglutinating antibodies (> or = 1:50 dilution) were found in 433 (92.3%) of the raccoons. This study indicates that exposure to S. neurona is high in this metropolitan area...
  83. ncbi Risk factors for owner-reported occurrence of equine protozoal myeloencephalitis in the US equine population
    P S Morley
    Animal Population Health Institute, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Vet Intern Med 22:616-29. 2008
    ..Equine protozoal myeloencephalitis (EPM) is a serious and often fatal neurologic disease of horses, but few studies have investigated risk factors...
  84. ncbi Diagnostic sensitivity of nasopharyngeal and nasal swabs for the molecular detection of EHV-1
    N Pusterla
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Vet Rec 162:520-1. 2008
  85. ncbi Detection of EHV-1 neuropathogenic strains using real-time PCR in the neural tissue of horses with myeloencephalopathy
    C M Leutenegger
    Lucy Whittier Molecular and Diagnostic Care Facility, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Vet Rec 162:688-90. 2008
  86. ncbi Cell-mediated immune responses in horses with equine protozoal myeloencephalitis
    Jennifer A Spencer
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA
    J Parasitol 90:428-30. 2004
    ..It appears that the parasite is also able to induce an immunosuppression toward parasite-derived antigens as parasite-specific responses are decreased...
  87. ncbi Evaluation and comparison of an indirect fluorescent antibody test for detection of antibodies to Sarcocystis neurona, using serum and cerebrospinal fluid of naturally and experimentally infected, and vaccinated horses
    Paulo C Duarte
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, California 95616, USA
    J Parasitol 90:379-86. 2004
    ..The S. neurona vaccine could possibly interfere with equine protozoal myeloencephalitis diagnosis...
  88. ncbi Antibody index and specific antibody quotient in horses after intragastric administration of Sarcocystis neurona sporocysts
    Katherine A Heskett
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Vet Res 69:403-9. 2008
    ....
  89. ncbi Neurobrucellosis: clinical and neuroimaging correlation
    M Walid Al-Sous
    Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    AJNR Am J Neuroradiol 25:395-401. 2004
    ....
  90. ncbi What is your neurologic diagnosis? Equine protozoal myeloencephalitis
    Laura H Javsicas
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    J Am Vet Med Assoc 232:201-4. 2008
  91. ncbi Infection of immunodeficient horses with Sarcocystis neurona does not result in neurologic disease
    Debra C Sellon
    Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99163, USA
    Clin Diagn Lab Immunol 11:1134-9. 2004
    ....
  92. ncbi Modest genetic differentiation among North American populations of Sarcocystis neurona may reflect expansion in its geographic range
    N Sundar
    United States Department of Agriculture, Agricultural Research Service, Animal Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705 2350, USA
    Vet Parasitol 152:8-15. 2008
    ..Moreover, our study confirms that diverse intermediate hosts share a common infection source, the opossum (Didelphis virginiana)...
  93. ncbi Characterization of a serine protease activity in Sarcocystis neurona merozoites
    S C Barr
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Parasitol 89:385-8. 2003
    ..The protease activity described here could be a potential target for chemotherapy development...
  94. ncbi Neurological syndromes among horses in The Netherlands. A 5 year retrospective survey (1999-2004)
    L S Goehring
    Department of Equine Sciences, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Vet Q 27:11-20. 2005
    ..The pathogenesis of each disease is presented, followed by a description of a general presentation of the diseases as encountered under Dutch circumstances...
  95. ncbi The seroprevalence of antibodies to Sarcocystis neurona in Michigan equids
    M G Rossano
    The Population Medicine Center, College of Veterinary Medicine, A-109 Veterinary Medical Center, Michigan State University, 48824-1314, East Lansing, MI, USA
    Prev Vet Med 48:113-28. 2001
    ..No association was found between farm size, animal gender, hay types, horse-housing types or exposure to natural surface water and seropositivity...
  96. ncbi Immune response to Sarcocystis neurona infection in naturally infected horses with equine protozoal myeloencephalitis
    Jibing Yang
    Department of Large Animal Clinical Sciences, Phase II, Duck Pond Dr, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, 24061, USA
    Vet Parasitol 138:200-10. 2006
    ..neurona in horses, as well as to determine the mechanism associated with suppressed in vitro proliferation responses. Finally, overnight storage of blood samples appears to alter T lymphocyte phenotypes and viability among leukocytes...
  97. ncbi Clinical diagnosis of equine protozoal myeloencephalitis (EPM)
    Martin Furr
    Marion duPont Scott Equine Medical Center, Virginia-Maryland Regional College of Veterinary Medicine, Leesburg, VA 20177, USA
    J Vet Intern Med 16:618-21. 2002
  98. ncbi Folate deficiency during treatment with orally administered folic acid, sulphadiazine and pyrimethamine in a horse with suspected equine protozoal myeloencephalitis (EPM)
    R J Piercy
    Department of Clinical Veterinary Science, The Ohio State University, Columbus 43210, USA
    Equine Vet J 34:311-6. 2002
  99. ncbi Immunoconversion against Sarcocystis neurona in normal and dexamethasone-treated horses challenged with S. neurona sporocysts
    T J Cutler
    Department of Pathobiology, PO Box 100880, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    Vet Parasitol 95:197-210. 2001
    ..Future work must focus on defining the factors that govern progression of inapparent S. neurona infection to EPM...
  100. ncbi Reduced levels of nitric oxide metabolites in cerebrospinal fluid are associated with equine protozoal myeloencephalitis
    Chinedu J Njoku
    Department of Veterinary Preventive Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Clin Diagn Lab Immunol 9:605-10. 2002
    ..neurona-specific Abs in CSF alone and that reduced NO levels could be causally related to the development of EPM...
  101. ncbi Cytokine gene signatures in neural tissue of horses with equine protozoal myeloencephalitis or equine herpes type 1 myeloencephalopathy
    N Pusterla
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Rec 159:341-6. 2006
    ..In the horses with ehv-1 the proinflammatory cytokine IL-8 was commonly expressed, but IL-10 and IFN-gamma were not, and TNF-alpha was rare. Tissue from the control horses expressed only the gene GAPDH...

Research Grants88

  1. 2nd International Pathogenesis of Rare Neuroimmunologic Disorders
    Douglas Kerr; Fiscal Year: 2006
    ..syndrome (SPS), neuromyelitis optica (NMO), optic neuritis (ON), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), Hashimoto?s encephalitis, Rasmussen?s encephalitis, paraneoplastic encephalomyelitis (PE), and ..
  2. CD-73 adenosine signaling in the central nervous system in disease and health
    MARGARET BYNOE; Fiscal Year: 2009
    ..Experimental Autoimmune Encephalomyelitis (EAE) is a mouse model for MS, and like MS, is an autoimmune disease mediated by proinflammatory immune ..
  3. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2010
    ..and regulator of innate and adaptive immune responses, and autoimmune diseases such as experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis (MS)...
  4. ACUTE ALPHAVIRUAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2007
    ..and feared diseases of humans - for instance, rabies, poliomyelitis and, most recently, West Nile virus encephalomyelitis. These diseases are often dramatic in their rapid onset and progression...
  5. CD-73 adenosine signaling in the central nervous system in disease and health
    Margaret S Bynoe; Fiscal Year: 2010
    ..Experimental Autoimmune Encephalomyelitis (EAE) is a mouse model for MS, and like MS, is an autoimmune disease mediated by proinflammatory immune ..
  6. CD-73 adenosine signaling in the central nervous system in disease and health
    Margaret S Bynoe; Fiscal Year: 2010
    ..Experimental Autoimmune Encephalomyelitis (EAE) is a mouse model for MS, and like MS, is an autoimmune disease mediated by proinflammatory immune ..
  7. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..Similarly, the severity of experimental autoimmune encephalomyelitis (EAE), an MS-like disease in mice, is also diminished during pregnancy...
  8. Phytoestrogens as an alternative treatment for MS
    Bruce Bebo; Fiscal Year: 2005
    ..Similarly, the severity of experimental autoimmune encephalomyelitis (EAE), an MS-like disease in mice, is also diminished during pregnancy...
  9. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
    ..myelin basic protein (MBP) and proteolipid protein (PLP) can induce severe signs of experimental autoimmune encephalomyelitis (EAE) in mice that include ascending paralysis, demyelination and axonal damage...
  10. Development of a T cell specific multiple sclerosis drug
    Arthur Vandenbark; Fiscal Year: 2005
    ..therapeutic activity in DR2 transgenic (Tg) mice with MOG-35-55 peptide induced experimental autoimmune encephalomyelitis (EAE) through mechanisms that include partial agonist signaling and cytokine switching of targeted T cells ..
  11. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2010
    ..with the GSK3 inhibitor lithium are completely protected from development of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, and that lithium treatment after onset of clinical disease ameliorates EAE and ..
  12. Autoantibody Arrays Guide Tolergenic Therapy for Multiple Sclerosis
    Lawrence Steinman; Fiscal Year: 2010
    ..Epitope spreading" is an immunological hallmark of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  13. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2009
    ..with the GSK3 inhibitor lithium are completely protected from development of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, and that lithium treatment after onset of clinical disease ameliorates EAE and ..
  14. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2007
    Theiler's murine encephalomyelitis virus (TMEV) induces chronic inflammatory demyelinating disease in susceptible mice...
  15. A VIRUS-INDUCED MOLECULAR MIMICRY MODEL OF MS
    Stephen Miller; Fiscal Year: 2007
    ..Our studies in the Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease model of MS have shown that CNS demyelination in SJL mice ..
  16. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2010
    Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are believed to be initiated by T cell-mediated immune responses to myelin antigens...
  17. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2004
    Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated inflammatory demyelinating disease of the CNS that serves as a model for human multiple sclerosis (MS)...
  18. CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines
    Iain Campbell; Fiscal Year: 2007
    ..e. lymphocytic choriomeningitis and MHV encephalomyelitis), and (iii) myelin oligodendrocyte peptide (MOG) immunization-induced experimentalautoimmune ..
  19. Inflammation and Degeneration of Optic Nerve in EAE
    Naren Banik; Fiscal Year: 2009
    ..a calcium (Ca2+)-dependent protease, in optic nerve using an animal model of MS, experimental allergic encephalomyelitis (EAE), in Lewis rats has implied a role for calpain in optic nerve damage in EAE...
  20. Inflammation and Degeneration of Optic Nerve in EAE
    Naren L Banik; Fiscal Year: 2010
    ..a calcium (Ca2+)-dependent protease, in optic nerve using an animal model of MS, experimental allergic encephalomyelitis (EAE), in Lewis rats has implied a role for calpain in optic nerve damage in EAE...
  21. ECOLOGY OF ENCEPHALITIS VIRUS IN THE SOUTHEASTERN USA
    THOMAS UNNASCH; Fiscal Year: 2003
    Several arboviral encephalomyelitis viruses, most importantly Eastern Equine Encephalomyelitis and Saint Louis Encephalomyelitis virus (EEE and SLE) cause sporadic epidemics in the human populations of the Southeastern US...
  22. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2007
    Experimental autoimmune encephalomyelitis (EAE) is a CD4+ T cell-mediated inflammatory CNS demyelinating disease that serves as a model for human multiple sclerosis (MS)...
  23. The Role of Dendritic Cells in Intravenous Tolerance
    Abdolmohamad Rostami; Fiscal Year: 2010
    ..v.) of soluble proteins can induce antigen-specific tolerance in experimental autoimmune encephalomyelitis (EAE). I.V. tolerance effectively prevents or suppresses the disease...
  24. The Role of Dendritic Cells in Intravenous Tolerance
    Abdolmohamad Rostami; Fiscal Year: 2009
    ..v.) of soluble proteins can induce antigen-specific tolerance in experimental autoimmune encephalomyelitis (EAE). I.V. tolerance effectively prevents or suppresses the disease...
  25. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC RELAPSING EAE
    Stephen Miller; Fiscal Year: 2000
    Experimental autoimmune encephalomyelitis (EAE) is a T cell- mediated inflammatory demyelinating disease of the CNS that serves as a model for human multiple sclerosis...
  26. B7/CD28/CTLA-4 COSTIMULATION IN PATHOGENESIS OF R-EAE
    Stephen Miller; Fiscal Year: 2003
    ..on the initiation and progression of both acute and relapsing-remitting forms of experimental autoimmune encephalomyelitis (EAE), a CD4+ T-cell-mediated autoimmune disease which serves as a model for multiple sclerosis...
  27. The Effects of Alcohol on JNK Mediated Inflammatory Signaling in Glial Cells
    Jack L Leonard; Fiscal Year: 2010
    ..recent discovery that loss of the JNK1 gene protects the brain against the untoward effects of autoimmune encephalomyelitis highlights the potential role that the JNK signal transduction pathway plays in controlling the neuroimmune ..
  28. The Effects of Alcohol on JNK Mediated Inflammatory Signaling in Glial Cells
    Jack Leonard; Fiscal Year: 2009
    ..recent discovery that loss of the JNK1 gene protects the brain against the untoward effects of autoimmune encephalomyelitis highlights the potential role that the JNK signal transduction pathway plays in controlling the neuroimmune ..
  29. Myelin Composition Influence on Bilayer Interactions in Multiple Sclerosis
    Jacob Israelachvili; Fiscal Year: 2009
    ..potentially important changes in the lipid composition of brain myelin occur during experimental allergic encephalomyelitis (EAE), an established animal model of Multiple Sclerosis...
  30. Protective Effect of Pregnancy Doses of Estrogens in EAE
    Rhonda Voskuhl; Fiscal Year: 2005
    ..In murine experimental autoimmune encephalomyelitis (EAE), estrogen treatment has been shown to cause a favorable shift in cytokine profile with an increase in ..
  31. CB2 Receptor Regulatin of Inflammatory Response in EAE
    Doina Ganea; Fiscal Year: 2009
    ..Preliminary results showed that stimulation of CB2 receptors decreases CNS damage in experimental autoimmune encephalomyelitis (EAE)...
  32. Genetic Basis for susceptibility to Experimental Autoimmune Encephalomyelitis
    Vijay Kuchroo; Fiscal Year: 2007
    Experimental autoimmune encephalomyelitis (EAE) is an animal model for human MS that can be induced in experimental animals by immunization with myelin antigens...
  33. CB2 Receptor Regulatin of Inflammatory Response in EAE
    Ronald F Tuma; Fiscal Year: 2010
    ..Preliminary results showed that stimulation of CB2 receptors decreases CNS damage in experimental autoimmune encephalomyelitis (EAE)...