Genomes and Genes
Summary: Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
Publications202 found, 100 shown here
- Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitisTian Wang
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA
Nat Med 10:1366-73. 2004..Collectively, WNV infection leads to a Tlr3-dependent inflammatory response, which is involved in brain penetration of the virus and neuronal injury...
- The TIMPs tango with MMPs and more in the central nervous systemStephen J Crocker
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci Res 75:1-11. 2004....
- Brain inflammation in epilepsy: experimental and clinical evidenceAnnamaria Vezzani
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Epilepsia 46:1724-43. 2005..The elucidation of this aspect may open new perspectives for the pharmacologic treatment of seizures...
- Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1J J Schlesinger
J Gen Virol 68:853-7. 1987..Induction of a protective immune response by NS1 suggests that it be considered for incorporation into possible synthetic or recombinant DNA DEN vaccines...
- Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown originH Pruss
Charite University Medicine Berlin, Department of Neurology, Chariteplatz 1, 10117 Berlin, Germany
Neurology 75:1735-9. 2010Anti-NMDA-receptor (NMDAR) encephalitis is a severe disorder that occurs in association with antibodies to the NR1 subunit of the NMDAR and results in a characteristic syndrome.
- Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disordersJohn W Phillis
Department of Physiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Brain Res Rev 52:201-43. 2006..Here, we review present knowledge of the functions of cyclooxygenases, lipoxygenases, and epoxygenases in brain and their association with neurodegenerative diseases...
- Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescentsNicole R Florance
Division of Neurology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Ann Neurol 66:11-8. 2009To report the clinical features of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in patients < or = 18 years old.
- Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's diseaseYoon Seong Kim
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
Exp Mol Med 38:333-47. 2006..In the last part, microglial activation and their role in PD are discussed in depth...
- Rift Valley fever encephalitisAbdulrahman A Alrajhi
Emerg Infect Dis 10:554-5. 2004
- Rasmussen's encephalitis: early characteristics allow diagnosisT Granata
Division of Child Neurology, Istituto Nazionale Neurologico C Besta, Milan, Italy
Neurology 60:422-5. 2003To identify early manifestations of Rasmussen encephalitis (RE) that can prompt early and reasonably secure diagnosis, allowing medical or surgical therapies at an early stage when they may be more effective in slowing the disease.
- Silencing early viral replication in macrophages and dendritic cells effectively suppresses flavivirus encephalitisChunting Ye
Paul L Foster School of Medicine, Center of Excellence in Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
PLoS ONE 6:e17889. 2011West Nile (WN) and St. Louis encephalitis (SLE) viruses can cause fatal neurological infection and currently there is neither a specific treatment nor an approved vaccine for these infections...
- Encephalitis and myelitis associated with dengue viral infection clinical and neuroimaging featuresMohammad Wasay
Department of Neurology, The Aga Khan University, Karachi, Pakistan
Clin Neurol Neurosurg 110:635-40. 2008The objective of this study was to identify clinical and neuroimaging features and outcome of patients with encephalitis and myelitis associated with dengue viral infection.
- Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodiesJosep Dalmau
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Lancet Neurol 7:1091-8. 2008A severe form of encephalitis associated with antibodies against NR1-NR2 heteromers of the NMDA receptor was recently identified...
- Epstein-Barr virus infections of the central nervous systemHiroshi Fujimoto
First Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011
Intern Med 42:33-40. 2003..The neurologic forms were as follows: acute encephalitis (4 patients), acute cerebellar ataxia (1), acute disseminated encephalomyelitis (ADEM) (2), myelitis (1), and ..
- Testicular teratoma and anti-N-methyl-D-aspartate receptor-associated encephalitisA Eker
J Neurol Neurosurg Psychiatry 79:1082-3. 2008
- Tumor necrosis factor alpha is reparative via TNFR2 [corrected] in the hippocampus and via TNFR1 [corrected] in the striatum after virus-induced encephalitisMoses Rodriguez
Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Brain Pathol 19:12-26. 2009..of tumor necrosis factor alpha (TNFalpha) in parenchymal brain pathology resolution following virus-induced encephalitis from a picornavirus, Theiler's murine encephalomyelitis virus (TMEV)...
- Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitisLarisa Poluektova
Laboratory of Neuroregeneration, Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Glia 52:344-53. 2005..Activated MPs effect a giant cell encephalitis and neuroinflammatory responses that are mirrored in severe combined immunodeficient (SCID) mice injected with ..
- N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexesSarosh R Irani
Department of Clinical Neurology, L6 West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
Brain 133:1655-67. 2010..Four patients, who only had temporal lobe epilepsy without oligoclonal bands, may represent restriction to the first stage...
- Cellular and synaptic mechanisms of anti-NMDA receptor encephalitisEthan G Hughes
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 30:5866-75. 2010We recently described a severe, potentially lethal, but treatment-responsive encephalitis that associates with autoantibodies to the NMDA receptor (NMDAR) and results in behavioral symptoms similar to those obtained with models of genetic ..
- Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective studyJulia Granerod
Centre for Infections, Health Protection Agency, London, UK
Lancet Infect Dis 10:835-44. 2010b>Encephalitis has many causes, but for most patients the cause is unknown. We aimed to establish the cause and identify the clinical differences between causes in patients with encephalitis in England.
- Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratomaJosep Dalmau
Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Neurol 61:25-36. 2007To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis.
- Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescentsNicole Florance-Ryan
Division of Neurology, Department of Pediatrics, Children s Hospital of Philadelphia, and Division of Neuro Oncology, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Curr Opin Pediatr 22:739-44. 2010Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently identified disorder that is increasingly recognized in children and adolescents. Prompt diagnosis and treatment are important to obtain full recovery...
- Spatial analysis of the distribution of LaCrosse encephalitis in Illinois, using a geographic information system and local and global spatial statisticsU Kitron
College of Veterinary Medicine, University of Illinois, Urbana 61801, USA
Am J Trop Med Hyg 57:469-75. 1997The spatial and temporal distribution of LaCrosse encephalitis cases in Illinois was analyzed using a geographic information system (GIS) and spatial statistics...
- A patient with encephalitis associated with NMDA receptor antibodiesLauren H Sansing
Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Nat Clin Pract Neurol 3:291-6. 2007..There was muscle rigidity, frequent facial grimacing, rhythmic abdominal contractions, kicking motions of the legs, and intermittent dystonic postures of the right arm...
- Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitisM Seki
Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
J Neurol Neurosurg Psychiatry 79:324-6. 2008We report an 18-year-old woman with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, who developed psychiatric symptoms, progressive unresponsiveness, dyskinesias, hypoventilation, hypersalivation and seizures...
- The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditionsSøren Lund
H Lundbeck A S, Valby, Denmark
J Neuroimmunol 180:71-87. 2006..Although most inflammatory genes induced in vitro were transferable to our in vivo model, the observed discrepancy for some genes potentially represents regulatory factors present in the central nervous system (CNS) but not in vitro...
- Inflammatory and injury responses to ischemic stroke in obese miceSatoshi Terao
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Stroke 39:943-50. 2008..This study tested the hypothesis that obesity exacerbates the cerebrovascular dysfunction and tissue injury induced by brain ischemia and reperfusion...
- The distinctive movement disorder of ovarian teratoma-associated encephalitisTimothy J Kleinig
Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Mov Disord 23:1256-61. 2008The movement disorder observed in four cases of ovarian teratoma associated encephalitis is described...
- Successful treatment of anti-N-methyl-D-aspartate receptor encephalitis presenting with catatoniaM Schimmel
Department of Paediatrics, Klinikum Augsburg, Stenglinstrasse 2, Augsburg, Germany
Arch Dis Child 94:314-6. 2009..girl with the typical clinical symptoms of the recently described anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is reported...
- Role of brain inflammation in epileptogenesisJieun Choi
Department of Pediatrics, Division of Neurology, Northwestern University Children s Memorial Hospital, Chicago, IL 2300 Children s Plaza, Box 51, Children s Memorial Hospital, Chicago, IL 60614, USA
Yonsei Med J 49:1-18. 2008..We provide an overview of the current knowledge that implicates brain inflammation as a common predisposing factor in epilepsy, particularly childhood epilepsy...
- Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitisM S Gable
Department of Psychiatry, University of California San Francisco, Fresno, CA, USA
Eur J Clin Microbiol Infect Dis 28:1421-9. 2009The California Encephalitis Project (CEP), established in 1998 to explore encephalitic etiologies, has identified patients with N-methyl-D-aspartate receptor (NMDAR) antibodies, the likely etiology of their encephalitis...
- Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de RechercheKeith Chirgwin
Department of Medicine, State University of New York at Brooklyn, NY, USA
Clin Infect Dis 34:1243-50. 2002..daily) as treatment for acute disease (for 6 weeks) and as maintenance therapy (for 42 weeks) for toxoplasmic encephalitis (TE) in patients infected with human immunodeficiency virus...
- Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanismJames Sissons
School of Biological and Chemical Sciences, Birkbeck, College, University of London, London WC1E 7HX, England, United Kingdom
Infect Immun 73:2704-8. 2005Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the ..
- Acanthamoeba encephalitisV Kaushal
Department of Microbiology, Dayanand Medical College and Hospital, Ludhiana 141 001, Punjab, India
Indian J Med Microbiol 26:182-4. 2008Central nervous system infection with free-living amoebae is rare. We present a fatal case of Acanthamoeba encephalitis in a 63-year-old female from India where acanthamoebae were demonstrated and cultured from CSF...
- Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's diseaseMasashi Kitazawa
Department of Neurobiology and Behavior, University of California Irvine, California 92697 4545, USA
J Neurosci 25:8843-53. 2005..Therefore, this study clearly demonstrates that microglial activation exacerbates key neuropathological features such as tangle formation...
- The role of astrocytes in the immunopathogenesis of toxoplasmic encephalitisEmma H Wilson
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6008, USA
Int J Parasitol 34:543-8. 2004..rarely leads to disease but in the immunocompromised host reactivation of these cysts can lead to toxoplasmic encephalitis. It is known that both CD4(+) and CD8(+) T cells are important in preventing reactivation of the parasite, ..
- Acute encephalitis with refractory, repetitive partial seizures: case reports of this unusual post-encephalitic epilepsyYoshiaki Saito
Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36 1 Nishi cho, Yonago 683 8504, Japan
Brain Dev 29:147-56. 2007We report on three acute encephalitis patients with refractory, repetitive partial seizures (AERRPS)...
- A case of acute encephalitis with refractory, repetitive partial seizures, presenting autoantibody to glutamate receptor Gluepsilon2Hiromichi Ito
Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
Brain Dev 27:531-4. 2005..We diagnosed him as encephalitis/encephalopathy, and treated him with artificial respiration, thiamylal sodium, mild hypothermia therapy, ..
- Epistasis in sporadic Alzheimer's diseaseOnofre Combarros
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
Neurobiol Aging 30:1333-49. 2009..We conclude that epistasis is a crucial feature of complex diseases, that its study is a promising approach to the genetics of AD and that larger and more rigorous studies are needed to establish interactions...
- Diagnosis, treatment, and prognosis of Mycoplasma pneumoniae childhood encephalitis: systematic review of 58 casesFlorian Daxboeck
Division of Hospital Hygiene, Clinical Institute for Hygiene and Medical Microbiology, University of Vienna, University Hospital Vienna, Vienna, Austria
J Child Neurol 19:865-71. 2004Most of the knowledge on Mycoplasma pneumoniae encephalitis in children is based on case reports or small case series...
- Cluster analysis for identifying sub-groups and selecting potential discriminatory variables in human encephalitisJemila S Hamid
Population Genomics Program, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
BMC Infect Dis 10:364. 2010b>Encephalitis is an acute clinical syndrome of the central nervous system (CNS), often associated with fatal outcome or permanent damage, including cognitive and behavioural impairment, affective disorders and epileptic seizures...
- Seizures in encephalitis: predictors and outcomeU K Misra
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow 226014, India
Seizure 18:583-7. 2009Seizures are common in encephalitis but there is paucity of comprehensive studies evaluating predictors of seizures.
- Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratomaErdem Tuzun
Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, University of Pennsylvania, 3 W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
Acta Neuropathol 118:737-43. 2009..report the immunopathological analysis of the brain and tumor of two patients who died of anti-NMDAR-associated encephalitis, and of the tumor of nine patients who recovered...
- Comparison of high and low doses of trimethoprim-sulfamethoxazole for primary prevention of toxoplasmic encephalitis in human immunodeficiency virus-infected patientsE Ribera
Servicio de Enfermedades Infecciosas, Hospital General Vall d Hebron, 08035 Barcelona, Spain
Clin Infect Dis 29:1461-6. 1999..61). These results indicate that high doses of co-trimoxazole appear to be more effective than low doses for lowering the risk of toxoplasmosis in HIV-infected patients and that rifampin therapy may reduce the efficacy of co-trimoxazole...
- [A case of herpes simplex encephalitis with cerebral white matter lesion after acyclovir administration]T Tamura
Department of Neurology, Southern Tohoku Neurosurgical Hospital, Fukushima
No To Hattatsu 22:488-93. 1990..that selectively affects temporal and frontal lobes with necrosis and hemorrhage, and no case of herpes simplex encephalitis (HSE) with white matter lesion in a diffuse fashion has previously been reported...
- Global neurologic deficits with baylisascaris encephalitis in a previously healthy teenagerColleen S Chun
Division of Pediatric Infectious Diseases, Department of Pediatrics, Kaiser Permanente Northwest, Portland, OR, USA
Pediatr Infect Dis J 28:925-7. 2009..This case identifies a new risk factor, altered behavior related to substance abuse, and a newly described outcome of cognitive deficits for B. procyonis disease in older children...
- Acute psychiatric illness in a young woman: an unusual form of encephalitisKaitlyn L Parratt
Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW
Med J Aust 191:284-6. 2009..NMDA) NR1-NR2 receptors in both serum and cerebrospinal fluid, consistent with anti-NMDA-receptor encephalitis, a severe, potentially lethal but treatment-responsive encephalitis often associated with ovarian tumour...
- Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitisM Deckert-Schlüter
Institut für Neuropathologie, Universitatskliniken Bonn, Bonn, Germany
Am J Pathol 154:1549-61. 1999..of cerebral endothelial cells, microglia, and astrocytes was evaluated in a model of murine Toxoplasma encephalitis (TE)...
- Brainstem encephalitis following influenza vaccination: favorable response to steroid treatmentRecai Turkoglu
Department of Neurology, Haydarpasa Numune State Hospital, Istanbul, Turkey
Vaccine 27:7253-6. 2009..Our case implies that vaccination might be related with a wide range of clinical syndromes, including brainstem encephalitis.
- Bispectral index (BIS) monitoring of acute encephalitis with refractory, repetitive partial seizures (AERRPS)A A Dahaba
Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria
Minerva Anestesiol 76:298-301. 2010..Acute encephalitis with refractory, repetitive, partial seizures (AERRPS) is an epileptic syndrome first described by Sakuma in ..
- Anti-N-methyl-D-aspartate receptor encephalitis in a young woman with an ovarian tumourJoyce W T Lo
Department of Medicine, Ruttonjee Hospital, Wanchai, Hong Kong
Hong Kong Med J 16:313-6. 2010Anti-N-methyl-D-aspartate receptor encephalitis is characterised by psychiatric and neurological abnormalities and occurs in frequent association with ovarian teratoma...
- Cortical hypometabolism demonstrated by PET in relapsing NMDA receptor encephalitisSekhar C Pillai
Neuroimmunology Group, Institute for Neuroscience and Muscle Research, The Children s Hospital at Westmead, University of Sydney, Sydney, NSW, Australia
Pediatr Neurol 43:217-20. 2010N-methyl-d-aspartate (NMDA) receptor encephalitis is a newly defined type of autoimmune encephalitis...
- Challenge of the unknown. A systematic review of acute encephalitis in non-outbreak situationsJ Granerod
Health Protection Agency Centre for Infections, Virus Reference Department, 61 Colindale Avenue, London, UK
Neurology 75:924-32. 2010The threat of emerging infections and recognition of novel immune-mediated forms of encephalitis has raised the profile of this condition in recent years. Incidence is poorly defined and most cases have an unknown cause...
- Raccoon roundworm (Baylisascaris procyonis) encephalitis: case report and field investigationS Y Park
Division of Pediatric Infectious Diseases, University of California, San Francisco, San Francisco, California 94143 0136, USA
Pediatrics 106:E56. 2000..We report a case of severe raccoon roundworm (B procyonis) encephalitis in a young child to illustrate the unique clinical, diagnostic, and treatment aspects, as well as public health ..
- Neuronal apoptosis does not play an important role in human rabies encephalitisAlan C Jackson
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
J Neurovirol 14:368-75. 2008It is generally accepted that there are not prominent features of neuronal cell death in rabies encephalitis. However, Hemachudha and coworkers recently reported widespread apoptosis in the central nervous system of several human rabies ..
- Nationwide survey of acute juvenile female non-herpetic encephalitis in Japan: relationship to anti-N-methyl-D-aspartate receptor encephalitisSatoshi Kamei
Department of Medicine, Nihon University School of Medicine, Tokyo
Intern Med 48:673-9. 2009To study the incidence and clinical features of acute juvenile female non-herpetic encephalitis (AJFNHE) in Japan.
- NF-kappaB signaling in cerebral ischemiaD A Ridder
Pharmacological Institute, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Neuroscience 158:995-1006. 2009..Modulation of NF-kappaB signaling has the potential to interrupt multiple inflammatory and apoptotic mechanisms through one specific molecular target...
- Brainstem and striatal encephalitis complicating Mycoplasma pneumoniae pneumonia: possible benefit of intravenous immunoglobulinG Sakoulas
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Pediatr Infect Dis J 20:543-5. 2001..A trial of intravenous immunoglobulin in a critically ill patient with encephalitis that developed in parallel to M...
- Acute encephalitis with refractory, repetitive partial seizuresHiroshi Sakuma
Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1 Ogawa higashicho, Kodaira, Japan
Brain Dev 31:510-4. 2009Acute encephalitis with refractory, repetitive partial seizures (AERRPS) represents a peculiar form of encephalitis mainly affecting children...
- Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gammaAndreas Strack
, , Joseph-Stelzmann-Str. 9, , Germany
Acta Neuropathol (Berl) 103:458-68. 2002..defines the kinetics and cellular sources of T cell- and macrophage-attracting chemokines in murine Toxoplasma encephalitis (TE) by ribonuclease protection assay, reverse transcription-PCR, in situ hybridization, and ..
- Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitisMia Levite
School of Behavioral Sciences, Academic College of TLV Yaffo, Israel The Weizmann Institue of Science, Rehovot 76100, Israel
Expert Rev Neurother 8:1141-60. 2008..to our attention, as they are found in many patients with epilepsy, systemic lupus erythematosus (SLE) and encephalitis, and can unquestionably cause brain damage...
- Anti-N-methyl-D-aspartate-receptor encephalitis in a four-year-old girlRoberta Biancheri
Child Neurology and Psychiatry Unit, G Gaslini Institute and University of Genova, Largo G Gaslini 5, 16147 Genova, Italy
J Pediatr 156:332-4. 2010Anti-N-methyl-D-aspartate-receptor encephalitis is a recently identified autoimmune disorder...
- The effect of activated microglia on astrogliosis parameters in astrocyte culturesClaudia Röhl
Department of Anatomy, University of Kiel, Olshausenstr 40, D 24098 Kiel, Germany
Brain Res 1129:43-52. 2007....
- Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammationY Marchalant
Arizona Research Laboratories, Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, USA
Neuroscience 144:1516-22. 2007....
- A novel role of glia maturation factor: induction of granulocyte-macrophage colony-stimulating factor and pro-inflammatory cytokinesAsgar Zaheer
Veterans Affair Medical Center, Iowa City, Iowa, USA
J Neurochem 101:364-76. 2007..Our results suggest a novel pathway of GMF-initiated cytotoxicity of brain cells, and implicate its involvement in inflammatory diseases such as multiple sclerosis...
- Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degenerationMaya G Purisai
The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
Neurobiol Dis 25:392-400. 2007..Data indicate that microglial activation and consequent induction of NADPH oxidase may act as risk factors for Parkinson's disease by increasing the vulnerability of dopaminergic cells to toxic injury...
- Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain"Edith V Sullivan
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
Exp Neurol 213:10-7. 2008
- Upregulation of CCAAT/enhancer binding protein beta in activated astrocytes and microgliaAroa Ejarque-Ortiz
Department of Pharmacology and Toxicology, IIBB CSIC, IDIBAPS, E 08036 Barcelona, Spain
Glia 55:178-88. 2007..Given the nature of the C/EBPbeta-regulated genes, we hypothesize that this factor participates in neurotoxic effects associated with glial activation. (c) 2006 Wiley-Liss, Inc...
- Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are presentJianrong Li
Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 28:5321-30. 2008....
- Induction of interleukin-1beta by interleukin-4 in lipopolysaccharide-treated mixed glial cultures: microglial-dependent effectsLing Cao
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Neurochem 102:408-19. 2007..Therefore, precaution should be taken when clinically using IL-4 to treat diseases manifested by overt inflammatory responses...
- Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the ratS Rosi
Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724, USA
Neuroscience 142:1303-15. 2006..Combined, these findings suggest that low, therapeutically relevant doses of memantine delivered early in the development of neuroinflammation-influenced diseases may confer neural and cognitive protection...
- Dissociation between hippocampal neuronal loss, astroglial and microglial reactivity after pharmacologically induced reverse glutamate transportLluïsa de Yebra
Unitat de Bioquimica, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, C Casanova 143, Barcelona E 08036, Spain
Neurochem Int 49:691-7. 2006..These data suggest a specific response of microglia to PDC whose neuronal effects may differ with the infused dose...
- Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic miceM Oksman
Department of Neuroscience and Neurology, University of Kuopio, Finland
Neurobiol Dis 23:563-72. 2006..The favorable effect of DHA on Abeta production was verified in two different cell lines. Regulation of dietary lipid intake may offer a new tool to reduce the risk of Alzheimer's disease at the population level...
- Modulation of microglial activation state following passive immunization in amyloid depositing transgenic miceDave Morgan
Alzheimer Research Laboratory, Department of Pharmacology and Molecular Therapeutics, University of South Florida, MDC Box 9, Tampa, FL 33612, United States
Neurochem Int 49:190-4. 2006....
- In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptorsHerve Boutin
CEA, DSV, I2BM, SHFJ, Laboratoire d Imagerie Moleculaire Experimentale, Orsay, France
Glia 55:1459-68. 2007..Further studies of this new compound should be carried out to better define its capacity to overcome the limitations of [(11)C]PK11195 for PBR PET imaging...
- Progress in periventricular leukomalaciaWenbin Deng
Department of Neurology, UC Davis School of Medicine, 2425 Stockton Blvd, Sacramento, CA 95817, USA
Arch Neurol 65:1291-5. 2008..Studies in animal models of PVL suggest that pharmacologic interventions that target these toxic molecules will be useful in diminishing the severity of PVL...
- Proteasomal inhibition in intracerebral hemorrhage: neuroprotective and anti-inflammatory effects of bortezomibDong In Sinn
Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University Hospital, Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, South Korea
Neurosci Res 58:12-8. 2007..We concluded that the early treatment with bortezomib induced a reduction in the early hematoma growth and mitigated the development of brain edema, coupled with a marked inhibitory effect on inflammation in ICH...
- Delayed peripheral administration of a GPE analogue induces astrogliosis and angiogenesis and reduces inflammation and brain injury following hypoxia-ischemia in the neonatal ratPernilla Svedin
The Liggins Institute, University of Auckland, Auckland, New Zealand
Dev Neurosci 29:393-402. 2007..The normalization of IL-6 levels and the promotion of both neovascularization and reactive astrocytosis may be potential mechanisms that underlie its protective effects...
- Translocator protein 18 kDa is involved in the regulation of reactive gliosisSergio Veiga
Instituto Cajal, C S I C, Madrid, Spain
Glia 55:1426-36. 2007..These findings identify TSPO as a potential target for controlling neural inflammation, showing that the TSPO ligand PK11195 may reduce microglia activation by a mechanism that is independent of the regulation of neuronal survival...
- Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivoCheng Fang Huang
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Neurosci Bull 24:66-72. 2008..To evaluate the role of thrombin-activated microglia in the neurodegeneration of nigral dopaminergic neurons in the rat substantia nigra (SN) in vivo...
- COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injuryDaniel T Laskowitz
Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
J Neurotrauma 24:1093-107. 2007..This represents a novel therapeutic strategy in the treatment of TBI...
- Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusionTeemu Helkamaa
Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
Neurochem Int 51:412-23. 2007..These changes in glial and perivascular catechol-O-methyltransferase activity may have clinical relevance for Parkinson's disease drug treatment due to increased metabolism of levodopa in the brain...
- A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activationSriram Venneti
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurochem 102:2118-31. 2007....
- Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptorJun Maeda
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
Brain Res 1157:100-11. 2007..The present findings collectively support the utility of PBR in identifying a unique temporal pattern of astrocytic and microglial activation that conventional glial markers hardly pursue...
- Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestrationKazuyuki Takata
Department of Neurobiology, Kyoto Pharmaceutical University and 21st Century COE Program, Kyoto 607 8414, Japan
Eur J Neurosci 26:2458-68. 2007..We conclude that deglycosylated antibodies effectively induced Abeta sequestration without provoking neuroinflammation; thus, these deglycosylated antibodies may be optimal for sequestration therapy for Alzheimer's disease...
- Japanese encephalitis virus infection decrease endogenous IL-10 production: correlation with microglial activation and neuronal deathVivek Swarup
National Brain Research Centre, Manesar, Haryana, India
Neurosci Lett 420:144-9. 2007..In order to assess functional importance of this cytokine in viral encephalitis we have exploited an experimental model of Japanese encephalitis (JE)...
- Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/AktBin Xing
Department of Anatomy and Neurobiology, 310 Davis Mills Building, University of Kentucky, Chandler Medical Center, 800 Rose Street, Lexington, KY 40536 0298, USA
J Neuroinflammation 5:4. 2008....
- Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanismEmmanuel Pinteaux
Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, UK
J Neurochem 102:826-33. 2007..These results confirm our earlier observations in vivo and demonstrate that microglia are an important source of IL-1beta in the brain in response to leptin...
- Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microgliaMami Noda
Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
J Neurochem 101:397-410. 2007..Our data imply that BK has anti-inflammatory and neuroprotective effects in the central nervous system by modulating microglial function...
- Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generationHan Qing Chen
School of Food Science and Technology, Southern Yangtze University, 1800 Lihu Road, Wuxi, Jiangsu 214122, P R China
Neurosci Lett 417:112-7. 2007..This study suggested for the first time that biochanin A protected dopaminergic neurons against LPS-induced damage through inhibition of microglia activation and proinflammatory factors generation...
- Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probesYinghui Zhong
Neurological Biomaterials and Therapeutics, Laboratory for Neuroengineering, Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332 0535, USA
Brain Res 1148:15-27. 2007..Thus anti-inflammatory probe coatings may represent a promising approach to attenuate astroglial scar and reduce neural loss around implanted neural probes...
- Complement activation in experimental and human temporal lobe epilepsyE Aronica
Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
Neurobiol Dis 26:497-511. 2007..The persistence of complement activation could contribute to a sustained inflammatory response and could destabilize neuronal networks involved...
- Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytesTakashi Iwai
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
Neurosci Res 55:352-60. 2006..GLP-1 also increased cAMP concentration and cAMP response element-binding protein phosphorylation in astrocytes. These results suggest that GLP-1 may be a modulator of inflammation in the central nervous system...
- P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brainP M Rappold
Department of Neurosurgery, Box 670, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Brain Res 1089:171-8. 2006..In addition, the morphological changes in microglia following seizure induction that can be identified with P2X7 antisera or with antisera specific for microglia suggest a neuroinflammatory milieu in areas of CNS seizure activity...
- Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 productionYuri Ikeda-Matsuo
Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, Japan
J Neurochem 94:1546-58. 2005..These results suggest that the activation of microglia contributes to PGE2 production through the concerted de novo synthesis of mPGES-1 and COX-2 at sites of inflammation of the brain parenchyma...
- Selective modulation of lipopolysaccharide-stimulated cytokine expression and mitogen-activated protein kinase pathways by dibutyryl-cAMP in BV2 microglial cellsMoon-Sook Woo
Department of Neuroscience, Ewha Institute of Neuroscience, College of Medicine, Ewha Womans University, 70 Jongno 6-Ga, Jongno-gu, Seoul 110-783, South Korea
Brain Res Mol Brain Res 113:86-96. 2003..Taken together, our results demonstrate that cAMP modulates microglia activation in a diverse and complex manner...
- Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activationLiya Qin
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Glia 52:78-84. 2005....
- Hypoxic induction of caspase-11/caspase-1/interleukin-1beta in brain microgliaNam Gon Kim
Department of Anatomy and Neurobiology, Institute of Health Sciences, and Research Institute of Natural Science, Gyeongsang National University College of Medicine, 92 Chilam dong, Jinju, Kyungnam 660 751, South Korea
Brain Res Mol Brain Res 114:107-14. 2003....
- Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatumJae K Ryu
Department of Pharmacology and Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Neurobiol Dis 20:550-61. 2005....
- Impaired capacity for upregulation of MHC class II in tumor-associated microgliaJill M Schartner
Department of Neurological Surgery, University of Wisconsin School of Medicine, Madison, WI 53792-3232, USA
Glia 51:279-85. 2005..Understanding the mechanism of these differences may be critical in the development of novel immunotherapies for malignant glioma...
- Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microgliaRavi Shankar Akundi
Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
Glia 51:199-208. 2005Microglia are the major cell type involved in neuroinflammatory events in brain diseases such as encephalitis, stroke, and neurodegenerative disorders, and contribute significantly to the release of prostaglandins (PGs) during neuronal ..
- Inhibition of the Membrane Fusion Proteins of Flaviviruses and AlphavirusesMargaret Kielian; Fiscal Year: 2007..and alphaviruses are spread by mosquito and tick vectors and cause severe human and animal illnesses such as encephalitis and hemorrhagic fever...
- 2nd International Pathogenesis of Rare Neuroimmunologic DisordersDouglas Kerr; Fiscal Year: 2006..NMO), optic neuritis (ON), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), Hashimoto?s encephalitis, Rasmussen?s encephalitis, paraneoplastic encephalomyelitis (PE), and pediatric autoimmune neuropsychiatric ..
- CHEMOKINE-MEDIATED NEUROPROTECTION AND REPAIR DURING WNV ENCEPHALITISROBYN SUE KLEIN; Fiscal Year: 2010..and their receptors in contributing to viral clearance, immunopathology and repair in a murine model of WNV encephalitis. Murine WNV infection is well-accepted flavivirus encephalitis model whereby subcutaneous infection with low ..
- Mechanisms of apoptosis in the central nervous systemKenneth Tyler; Fiscal Year: 2009Viral-induced encephalitis remains a major cause of morbidity and mortality throughout the world...
- Innate immune evasion and/or antagonism by eastern equine encephalitis virusKATHERINE RYMAN; Fiscal Year: 2007Eastern equine encephalitis virus (EEEV), an Alphavirus in the family Togaviridae, is classified in Category B of the NIH Priority Pathogens List, and as a high consequence livestock pathogen by the USDA because it is highly lethal for ..
- Invasion of California by West Nile VirusWilliam Reisen; Fiscal Year: 2007..Louis encephalitis virus [SLE] transmission provides a unique natural experiment to test the hypothesis that similarities in ..
- Characterization of the La Crosse Virus glycoprotein fusion peptideFrancisco Gonzalez Scarano; Fiscal Year: 2009La Crosse virus (LACV), a NIAID Category B priority pathogen, is a common cause of pediatric encephalitis and aseptic meningitis in areas of the Midwestern United States where its principal mosquito vector, Ochlerotatus (formerly Aedes) ..
- Characterization of the La Crosse Virus glycoprotein fusion peptideFrancisco Gonzalez Scarano; Fiscal Year: 2010La Crosse virus (LACV), a NIAID Category B priority pathogen, is a common cause of pediatric encephalitis and aseptic meningitis in areas of the Midwestern United States where its principal mosquito vector, Ochlerotatus (formerly Aedes) ..
- Replicon-based screening for inhibitors of alphavirusesPAUL OLIVO; Fiscal Year: 2005..We are particularly targeting the more pathogenic encephalitis-causing viruses from the alphavirus genus, such as Venezuelan equine encephalitis virus (VEEV), Eastern equine ..
- ACUTE ALPHAVIRUAL ENCEPHALITISDiane Griffin; Fiscal Year: 2007..are important causes of mosquito-borne encephalomyelitis and western, eastern and Venezuelan equine encephalitis viruses are considered category B agents of bioterrorist concern. VEEV has been weaponized...
- Novel Therapeutics for Neurotropic AlphavirusesDavid J Miller; Fiscal Year: 2010Neurotropic alphaviruses such as western, eastern, and Venezuelan equine encephalitis viruses are transmitted by mosquitoes, cause serious and potentially fatal central nervous system infections in humans, and are considered NIAID ..
- Virus-Host Interactions that Lead to EpilepsyRobert S Fujinami; Fiscal Year: 2011DESCRIPTION (provided by applicant): Viral infections of the central nervous system (CNS) can result in encephalitis. Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
- Virus-Host Interactions that Lead to EpilepsyRobert S Fujinami; Fiscal Year: 2010Viral infections of the central nervous system (CNS) can result in encephalitis. Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
- MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUSNigel Fraser; Fiscal Year: 2007Herpes Simplex virus (HSV) can cause a wide range of diseases including skin lesions which are common, encephalitis which is rare, an HSV infection of the eye which is a leading cause of blindness in the USA (400,000 cases)...
- ACUTE ALPHAVIRAL ENCEPHALITISDiane Griffin; Fiscal Year: 1999Alphaviruses, such as Eastern and Western equine encephalitis viruses, are important causes of mosquito-borne encephalitis in the Americas, and infected individuals have disease manifestations ranging from a mild febrile illness to fatal ..
- Modeling and empirical studies of arboviruses in FloridaCYNTHIA LORD; Fiscal Year: 2007..In 2002, there were over 4000 human cases of West Nile (WN) fever or encephalitis in the US. Other arboviruses such as St...
- Identification and Analysis of Flavivirus Protease and RNA Helicase InhibitorsRadhakrishnan Padmanabhan; Fiscal Year: 2009..These viruses, in addition to flu-like symptoms, can cause hemorrhagic fevers (YFV and DEN) or encephalitis and/or meningo-encephalitis in susceptible humans...
- Identification and Analysis of Flavivirus Protease and RNA Helicase InhibitorsRadhakrishnan Padmanabhan; Fiscal Year: 2007..These viruses, in addition to flu-like symptoms, can cause hemorrhagic fevers (YFV and DEN) or encephalitis and/or meningo-encephalitis in susceptible humans...
- MOLECULAR ANALYSIS OF ALPHAVIRUS MEMBRANE FUSION PROTEINMargaret Kielian; Fiscal Year: 2006Alphaviruses and flaviviruses are the causative agents of severe human and animal illnesses such as encephalitis, polyarthritis, and dengue fever, with millions of cases in humans per year...
- Immunity to brain Ma proteins: A remote effect of cancerJosep Dalmau; Fiscal Year: 2009..We identified this disorder in men with testicular tumors and brainstem and limbic encephalitis (LE) who developed antibodies to neuronal proteins expressed by the tumors...
- Immunity to brain Ma proteins: A remote effect of cancerJosep Dalmau; Fiscal Year: 2010..We identified this disorder in men with testicular tumors and brainstem and limbic encephalitis (LE) who developed antibodies to neuronal proteins expressed by the tumors...
- ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITISScott Weaver; Fiscal Year: 2005DESCRIPTION: Venezuelan equine encephalitis (VEE) is an emerging arboviral disease and a public and veterinary health threat throughout the Americas, including the United States...
- MOLECULAR ANALYSIS OF ALPHAVIRUS MEMBRANE FUSION PROTEINMargaret Kielian; Fiscal Year: 2009Alphaviruses and flaviviruses cause severe human and animal illnesses such as encephalitis, polyarthritis, and dengue fever, with millions of cases in humans per year...
- MOLECULAR ANALYSIS OF ALPHAVIRUS MEMBRANE FUSION PROTEINMargaret Kielian; Fiscal Year: 2010Alphaviruses and flaviviruses cause severe human and animal illnesses such as encephalitis, polyarthritis, and dengue fever, with millions of cases in humans per year...
- YELLOW FEVER 17D-BASED CHIMERIC FLAVIVIRUS VACCINESThomas Chambers; Fiscal Year: 2001Dengue and Japanese encephalitis viruses are important causes of human disease on a global scale and vaccine development against both viruses remains a public health priority...
- YELLOW FEVER 17D-BASED CHIMERIC FLAVIVIRUS VACCINESWilliam Wold; Fiscal Year: 2002Dengue and Japanese encephalitis viruses are important causes of human disease on a global scale and vaccine development against both viruses remains a public health priority...
- Viral Encephalitis, Chemokines and SleepLARRY D contact SANFORD; Fiscal Year: 2010..phase after inoculation with Vesicular Stomatitis Virus (VSV), a well- established animal model of viral encephalitis, and to determine the relationship these changes have to viral- induced changes in profiles of chemokines and ..
- Stable Micronized Vaccines Against Smallpox and Japanese EncephalitisVICTOR BRONSHTEIN; Fiscal Year: 2007..In recent years, mosquito-borne infections are reemerging or emerging worldwide at an alarming rate. Japanese Encephalitis is a potential agent of bioterrorism; it has been designated as Category C Priority Pathogen...