cholera

Summary

Summary: An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.

Top Publications

  1. ncbi [Cholera: recent acquisitions]
    Salvatore Nardiello
    Dipartimento Assistenziale di Malattie Infettive, Seconda Universita degli Studi di Napoli
    Infez Med 15:85-92. 2007
  2. ncbi Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Lancet 374:1694-702. 2009
  3. ncbi The origin of the Haitian cholera outbreak strain
    Chen Shan Chin
    Pacific Biosciences, Menlo Park, CA, USA
    N Engl J Med 364:33-42. 2011
  4. ncbi Environmental signatures associated with cholera epidemics
    Guillaume Constantin de Magny
    Institute for Advanced Computer Studies, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 105:17676-81. 2008
  5. ncbi Vibrio cholerae O1 hybrid El Tor strains, Asia and Africa
    Ashrafus Safa
    Emerg Infect Dis 14:987-8. 2008
  6. ncbi Cholera outbreaks caused by an altered Vibrio cholerae O1 El Tor biotype strain producing classical cholera toxin B in Vietnam in 2007 to 2008
    Binh Minh Nguyen
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Clin Microbiol 47:1568-71. 2009
  7. ncbi Association between climate variability and hospital visits for non-cholera diarrhoea in Bangladesh: effects and vulnerable groups
    Masahiro Hashizume
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 36:1030-7. 2007
  8. ncbi Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 44:4211-3. 2006
  9. ncbi New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 40:3296-9. 2002
  10. ncbi Evolution of new variants of Vibrio cholerae O1
    Ashrafus Safa
    Department of Biology and Chemistry and MERIT, City University of Hong Kong, 83, Tat Chee Avenue, Kowloon Tong, Kowloon, Hong Kong SAR
    Trends Microbiol 18:46-54. 2010

Research Grants

  1. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall K Holmes; Fiscal Year: 2010
  2. EPIDEMIOLOGY & ECOLOGY OF VIBRIO CHOLERAE IN BANGLADESH
    Richard Sack; Fiscal Year: 2000
  3. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2007
  4. Study of transmissible forms of Vibrio cholerae
    Andrew Camilli; Fiscal Year: 2007
  5. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
  6. PERTUSSIS, DIPHTHERIA, CHOLERA TOXINS--INHIBITOR DESIGN
    Vern Schramm; Fiscal Year: 1993
  7. Epidemiology and Ecology of Vibrio cholerae in Bangladesh
    Richard Bradley Sack; Fiscal Year: 2010
  8. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2010
  9. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2011
  10. A Screen for Small Molecule Compounds that Inhibit Bacterial Toxins
    David Haslam; Fiscal Year: 2007

Detail Information

Publications262 found, 100 shown here

  1. ncbi [Cholera: recent acquisitions]
    Salvatore Nardiello
    Dipartimento Assistenziale di Malattie Infettive, Seconda Universita degli Studi di Napoli
    Infez Med 15:85-92. 2007
    b>Cholera is still a medical problem in several countries, leading to the death of a large number of affected individuals...
  2. ncbi Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Lancet 374:1694-702. 2009
    Oral cholera vaccines consisting of killed whole cells have been available for many years, but they have not been used extensively in populations with endemic disease...
  3. ncbi The origin of the Haitian cholera outbreak strain
    Chen Shan Chin
    Pacific Biosciences, Menlo Park, CA, USA
    N Engl J Med 364:33-42. 2011
    Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera in Haiti.
  4. ncbi Environmental signatures associated with cholera epidemics
    Guillaume Constantin de Magny
    Institute for Advanced Computer Studies, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 105:17676-81. 2008
    The causative agent of cholera, Vibrio cholerae, has been shown to be autochthonous to riverine, estuarine, and coastal waters along with its host, the copepod, a significant member of the zooplankton community...
  5. ncbi Vibrio cholerae O1 hybrid El Tor strains, Asia and Africa
    Ashrafus Safa
    Emerg Infect Dis 14:987-8. 2008
  6. ncbi Cholera outbreaks caused by an altered Vibrio cholerae O1 El Tor biotype strain producing classical cholera toxin B in Vietnam in 2007 to 2008
    Binh Minh Nguyen
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Clin Microbiol 47:1568-71. 2009
    Vibrio cholerae O1 isolates collected during cholera outbreaks occurring from late 2007 to early 2008 in northern Vietnam were revealed to represent an altered strain containing the RS1 element followed by a CTX prophage harboring El Tor ..
  7. ncbi Association between climate variability and hospital visits for non-cholera diarrhoea in Bangladesh: effects and vulnerable groups
    Masahiro Hashizume
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 36:1030-7. 2007
    We estimated the effects of rainfall and temperature on the number of non-cholera diarrhoea cases and identified population factors potentially affecting vulnerability to the effect of the climate factors in Dhaka, Bangladesh.
  8. ncbi Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 44:4211-3. 2006
    We determined the types of cholera toxin (CT) produced by a collection of 185 Vibrio cholerae O1 strains isolated in Bangladesh over the past 45 years. All of the El Tor strains of V...
  9. ncbi New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 40:3296-9. 2002
    The sixth pandemic of cholera and, presumably, the earlier pandemics were caused by the classical biotype of Vibrio cholerae O1, which was progressively replaced by the El Tor biotype representing the seventh cholera pandemic...
  10. ncbi Evolution of new variants of Vibrio cholerae O1
    Ashrafus Safa
    Department of Biology and Chemistry and MERIT, City University of Hong Kong, 83, Tat Chee Avenue, Kowloon Tong, Kowloon, Hong Kong SAR
    Trends Microbiol 18:46-54. 2010
    Vibrio cholerae typically contains a prophage that carries the genes encoding the cholera toxin, which is responsible for the major clinical symptoms of the disease. In recent years, new pathogenic variants of V...
  11. ncbi Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Biol 8:129. 2010
    ..Here I describe studies with a live oral cholera vaccine that include older children no longer deriving immune support from breast milk or maternal antibodies and ..
  12. ncbi El Tor cholera with severe disease: a new threat to Asia and beyond
    A K Siddique
    Public Health Sciences Division PHSD, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Epidemiol Infect 138:347-52. 2010
    During epidemics of cholera in two rural sites (Bakerganj and Mathbaria), a much higher proportion of patients came for treatment with severe dehydration than was seen in previous years. V...
  13. ncbi Mucosal immunization with Vibrio cholerae outer membrane vesicles provides maternal protection mediated by antilipopolysaccharide antibodies that inhibit bacterial motility
    Anne L Bishop
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Infect Immun 78:4402-20. 2010
    Vibrio cholerae is the causative agent of cholera, a severe diarrheal disease that remains endemic in many parts of the world and can cause outbreaks wherever sanitation and clean water systems break down...
  14. ncbi The effect of rainfall on the incidence of cholera in Bangladesh
    Masahiro Hashizume
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Epidemiology 19:103-10. 2008
    The incidence of cholera in Bangladesh shows clear seasonality, suggesting that weather factors could play a role in its epidemiology. We estimated the effects of rainfall on the incidence of cholera in Dhaka, Bangladesh.
  15. ncbi FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae
    Marie Eve Val
    CNRS, Centre de Genetique Moleculaire, UPR 2167, Gif sur Yvette, France
    PLoS Genet 4:e1000201. 2008
    ..cholerae chromosomes. Chromosome II dimer resolution thus stands as a bona fide chromosomal process...
  16. ncbi The high burden of cholera in children: comparison of incidence from endemic areas in Asia and Africa
    Jacqueline L Deen
    International Vaccine Institute, Seoul, Korea
    PLoS Negl Trop Dis 2:e173. 2008
    b>Cholera remains an important public health problem. Yet there are few reliable population-based estimates of laboratory-confirmed cholera incidence in endemic areas around the world.
  17. ncbi Characterization of VPI pathogenicity island and CTXphi prophage in environmental strains of Vibrio cholerae
    A K Mukhopadhyay
    Departments of Molecular Microbiology and Genetics, Washington University Medical School, St. Louis, Missouri 63110, USA
    J Bacteriol 183:4737-46. 2001
    ..DNA (RAPD) fingerprint types from Calcutta, India, that were unusual in containing toxin-coregulated pilus or cholera toxin genes but not O1 or O139 antigens of epidemic strains were studied by PCR and sequencing to gain insights ..
  18. ncbi Activation of the Vibrio cholerae SOS response is not required for intestinal cholera toxin production or colonization
    Mariam Quinones
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Infect Immun 74:927-30. 2006
    b>Cholera toxin, one of the main virulence factors of Vibrio cholerae, is encoded in the genome of CTXphi, a V. cholerae-specific lysogenic filamentous bacteriophage...
  19. ncbi The sodium-driven flagellar motor controls exopolysaccharide expression in Vibrio cholerae
    Crystal M Lauriano
    Department of Biology, University of Texas San Antonio, 6900 N. Loop 1604 West, San Antonio, TX 78249-0662, USA
    J Bacteriol 186:4864-74. 2004
    Vibrio cholerae causes the life-threatening diarrheal disease cholera. This organism persists in aquatic environments in areas of endemicity, and it is believed that the ability of the bacteria to form biofilms in the environment ..
  20. ncbi Regulation of virulence in Vibrio cholerae: the ToxR regulon
    Brandon M Childers
    Department of Microbiology and Immunology, San Antonio, TX 78229 3900, USA
    Future Microbiol 2:335-44. 2007
    Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera. This disease consists of enormous fluid loss through stools, which can be fatal...
  21. ncbi Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR
    P J Cooper
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:1574-80. 2001
    ..of concurrent ascariasis on the cytokine response to a live oral vaccine, we measured cytokine responses to cholera toxin B subunit (CT-B) following vaccination with the live oral cholera vaccine CVD 103-HgR in Ascaris ..
  22. ncbi Cholera and climate: a demonstrated relationship
    Guillaume Constantin de Magny
    Center of Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, Biomolecular Sciences Building 296, College Park, MD 20742, USA
    Trans Am Clin Climatol Assoc 120:119-28. 2009
    Vibrio cholerae, the causative agent of cholera, is naturally present in the environment and autochthonous to coastal and estuarine ecosystems. V...
  23. ncbi Host-induced epidemic spread of the cholera bacterium
    D Scott Merrell
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nature 417:642-5. 2002
    ..Water-borne spread of the diarrhoeal disease cholera occurs rapidly in nature, whereas infection of human volunteers with bacteria grown in vitro is difficult in the ..
  24. ncbi Inapparent infections and cholera dynamics
    Aaron A King
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 454:877-80. 2008
    ..This is true for cholera, a pandemic bacterial disease, where estimates of the ratio of asymptomatic to symptomatic infections have ranged ..
  25. ncbi Vibrio cholerae and cholera: out of the water and into the host
    Joachim Reidl
    Zentrum für Infektionsforschung, Universitat Wurzburg, Wurzburg, Germany
    FEMS Microbiol Rev 26:125-39. 2002
    ..V. cholerae is well recognized and extensively studied as the causative agent of the human intestinal disease cholera. In former centuries cholera was a permanent threat even to the highly developed populations of Europe, North ..
  26. ncbi Spatial and temporal distribution of cholera in Ecuador between 1991 and 1996
    Emmanuelle Chevallier
    Département d épidémiologie et de santé publique, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Eur J Public Health 14:274-9. 2004
    The seventh pandemic of cholera affected South America in 1991 after a century of absence. Favoured by local conditions, the epidemic of cholera in Ecuador had a rapid impact...
  27. ncbi Characterization of Vibrio cholerae outer membrane vesicles as a candidate vaccine for cholera
    Stefan Schild
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Infect Immun 77:472-84. 2009
    Outer membrane vesicles (OMVs) offer a new approach for an effective cholera vaccine...
  28. ncbi Glycogen contributes to the environmental persistence and transmission of Vibrio cholerae
    Lori Bourassa
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Microbiol 72:124-38. 2009
    ..Additionally, glycogen contributes to the pathogenesis of V. cholerae in a transmission model of cholera. A role for glycogen in the transmission of V...
  29. ncbi Protection from annual flooding is correlated with increased cholera prevalence in Bangladesh: a zero-inflated regression analysis
    Margaret Carrel
    Department of Geography, CB3220, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health 9:13. 2010
    ..of flood protection measures for a portion of an intensely monitored population in Matlab, Bangladesh, allows us to examine whether cholera outcomes respond positively or negatively to measures designed to control river flooding.
  30. ncbi Cholera in India: an analysis of reports, 1997-2006
    S Kanungo
    National Institute of Cholera and Enteric Diseases, P 33 CIT Road Scheme XM, Beliaghata, Kolkata, 700 010, India
    Bull World Health Organ 88:185-91. 2010
    To more accurately define the annual incidence of cholera in India, believed to be higher than reported to the World Health Organization (WHO).
  31. ncbi Growth in a biofilm induces a hyperinfectious phenotype in Vibrio cholerae
    Rita Tamayo
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, 804 Manning Dr, CB 7290, Chapel Hill, NC 27599, USA
    Infect Immun 78:3560-9. 2010
    ..Furthermore, this work implies the existence of factors specifically induced during growth in a biofilm that augment infection by V. cholerae...
  32. ncbi Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: a randomized, placebo-controlled trial
    Suman Kanungo
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Vaccine 27:6887-93. 2009
    Immune responses after one and two doses of the reformulated killed oral cholera vaccine were measured in a double-blind, randomized, placebo-controlled trial of 77 adults aged 18-40 years and 77 children aged 1-17 years residing in ..
  33. ncbi Influence of temperature and rainfall on the evolution of cholera epidemics in Lusaka, Zambia, 2003-2006: analysis of a time series
    Miguel Ángel Luque Fernández
    National Centre of Epidemiology CNE, Programa de Epidemiologia Aplicada de Campo, Instituto de Salud Carlos III, C Sinesio Delgado 6, Pabellón 12, 28029 Madrid, Spain
    Trans R Soc Trop Med Hyg 103:137-43. 2009
    In this study, we aimed to describe the evolution of three cholera epidemics that occurred in Lusaka, Zambia, between 2003 and 2006 and to analyse the association between the increase in number of cases and climatic factors...
  34. ncbi Clinical outcomes in household contacts of patients with cholera in Bangladesh
    Ana A Weil
    International Centre for Diarrhoeal Disease Research Dhaka, Bangladesh
    Clin Infect Dis 49:1473-9. 2009
    ..cholerae infection and associated clinical symptoms in household contacts of patients with cholera and to identify risk factors for development of severe dehydration in this cohort.
  35. ncbi A large cholera outbreak due to a new cholera toxin variant of the Vibrio cholerae O1 El Tor biotype in Orissa, Eastern India
    P Kumar
    Biotechnology Division, Defence Research and Development Establishment DRDE, Jhansi Road, Gwalior 474002, India
    J Med Microbiol 58:234-8. 2009
    A total of 32 Vibrio cholerae isolates were collected during a recent large cholera outbreak in Eastern India. Biochemical and serological studies revealed that all of the isolates belonged to serogroup O1, biotype El Tor, serotype Ogawa...
  36. ncbi Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae
    D Scott Merrell
    Tufts University School of Medicine, Department of Molecular Biology and Microbiology, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Microbiol 43:1471-91. 2002
    ..While cholera toxin and the toxin-coregulated pilus (TCP) are known to be essential for full virulence, the role that other ..
  37. ncbi Cholera in Mozambique, variant of Vibrio cholerae
    M Ansaruzzaman
    Emerg Infect Dis 10:2057-9. 2004
  38. ncbi Geographical distribution and risk factors associated with enteric diseases in Vietnam
    Louise A Kelly-Hope
    Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 76:706-12. 2007
    In Vietnam, shigellosis, typhoid fever, and cholera are important enteric diseases...
  39. ncbi Viable but nonculturable Vibrio cholerae O1 in biofilms in the aquatic environment and their role in cholera transmission
    Munirul Alam
    International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Proc Natl Acad Sci U S A 104:17801-6. 2007
    ..In contrast to biofilms produced in Mathbaria pond water, V. cholerae O1 in biofilms present in cholera stools and incubated under identical conditions as the Mathbaria pond water biofilms could not be cultured after ..
  40. ncbi Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae
    David M Raskin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:4636-41. 2007
    ..We suggest that the essential function of CgtA is as a repressor of the stringent response that acts by regulating SpoT activity to maintain low ppGpp levels when bacteria are growing in a nutrient-rich environment...
  41. ncbi Cholera outbreak in southern Tanzania: risk factors and patterns of transmission
    C J Acosta
    Ifakara Health Research and Development Centre, Ifakara, Tanzania
    Emerg Infect Dis 7:583-7. 2001
    To identify risk factors and describe the pattern of spread of the 1997 cholera epidemic in a rural area (Ifakara) in southern Tanzania, we conducted a prospective hospital-based, matched case- control study, with analysis based on the ..
  42. ncbi Global impact of Vibrio cholerae interactions with chitin
    Carla Pruzzo
    Dipartimento di Biologia, Universita di Genova, Corso Europa 26, 16132 Genova, Italy
    Environ Microbiol 10:1400-10. 2008
    ..cholerae interactions with chitin represent a useful model for examination of the role of primary habitat selection in the development of traits that have been identified as virulence factors in human disease...
  43. ncbi Reduction of cholera in Bangladeshi villages by simple filtration
    Rita R Colwell
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 100:1051-5. 2003
    Based on results of ecological studies demonstrating that Vibrio cholerae, the etiological agent of epidemic cholera, is commensal to zooplankton, notably copepods, a simple filtration procedure was developed whereby zooplankton, most ..
  44. ncbi Oral cholera vaccines: use in clinical practice
    David R Hill
    National Travel Health Network and Centre, London, UK
    Lancet Infect Dis 6:361-73. 2006
    b>Cholera continues to occur globally, particularly in sub-Saharan Africa and Asia. Oral cholera vaccines have been developed and have now been used for several years, primarily in traveller populations...
  45. ncbi Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 103:6350-5. 2006
    ..Although the epidemic diarrheal disease cholera is known to be transmitted by water contaminated with pathogenic Vibrio cholerae, routine isolation of pathogenic ..
  46. ncbi Safety of rapid intravenous rehydration and comparative efficacy of 3 oral rehydration solutions in the treatment of severely malnourished children with dehydrating cholera
    Nur H Alam
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    J Pediatr Gastroenterol Nutr 48:318-27. 2009
    ..Assess the safety of rapid intravenous rehydration of severely malnourished children and compare the efficacy of 3 formulations of oral rehydration salts solutions...
  47. ncbi Mechanism of ToxT-dependent transcriptional activation at the Vibrio cholerae tcpA promoter
    Robin R Hulbert
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Bacteriol 184:5533-44. 2002
    ..ToxT is required for transcriptional activation of the genes encoding cholera toxin and the toxin coregulated pilus, among others...
  48. ncbi New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1
    Erica L Fonseca
    Instituto Oswaldo Cruz, Rio de Janeiro, Brazil and Instituto Nacional de Controle de Qualidade em Saúde, Rio de Janeiro
    Emerg Infect Dis 14:1129-31. 2008
    ..This qnrVC1 was in a typical class 1 integron. Its attC showed 89% identity with V. parahaemolyticus superintegron repeats. Analysis showed V. cholerae O1 carrying qnrVC2 associated with a V. cholerae superintegron repeat...
  49. ncbi Pandemic spread of cholera: genetic diversity and relationships within the seventh pandemic clone of Vibrio cholerae determined by amplified fragment length polymorphism
    Ruiting Lan
    Department of Microbiology, University of Sydney, NSW 2006, Australia
    J Clin Microbiol 40:172-81. 2002
    The seventh cholera pandemic started in 1961 and continues today. A collection of 45 seventh pandemic isolates of V. cholerae sampled over a 33-year period were analyzed by amplified fragment length polymorphism (AFLP) fingerprinting...
  50. ncbi A randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in Kolkata, India
    Dilip Mahalanabis
    Society for Applied Studies, Kolkata, India
    PLoS ONE 3:e2323. 2008
    An effective vaccine against cholera has been used for public health purposes in Vietnam since the 1990s. This vaccine was reformulated to meet WHO requirements...
  51. ncbi Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants
    M Shamim Hasan Zahid
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Infect Immun 76:5266-73. 2008
    Seasonal epidemics of cholera in Bangladesh are self-limited in nature, presumably due to phage predation of the causative Vibrio cholerae during the late stage of an epidemic, when cholera patients excrete large quantities of phage in ..
  52. ncbi Cholera transmission: the host, pathogen and bacteriophage dynamic
    Eric J Nelson
    Howard Hughes Medical Institute, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Rev Microbiol 7:693-702. 2009
    Zimbabwe offers the most recent example of the tragedy that befalls a country and its people when cholera strikes...
  53. ncbi Transmission of Vibrio cholerae is antagonized by lytic phage and entry into the aquatic environment
    Eric J Nelson
    Howard Hughes Medical Institute, USA
    PLoS Pathog 4:e1000187. 2008
    b>Cholera outbreaks are proposed to propagate in explosive cycles powered by hyperinfectious Vibrio cholerae and quenched by lytic vibriophage...
  54. ncbi Vibrio cholerae RND family efflux systems are required for antimicrobial resistance, optimal virulence factor production, and colonization of the infant mouse small intestine
    Xiaowen R Bina
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Infect Immun 76:3595-605. 2008
    Vibrio cholerae is a gram-negative human intestinal pathogen that causes the diarrheal disease cholera. Humans acquire cholera by ingesting V. cholerae-contaminated food or water. Upon ingestion, V...
  55. ncbi Vibrio cholerae O1 clinical strains isolated in 1992 in Kolkata with progenitor traits of the 2004 Mozambique variant
    Souvik Chatterjee
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    J Med Microbiol 58:239-47. 2009
    ....
  56. ncbi Evaluation of three rapid diagnostic tests for cholera: does the skill level of the technician matter?
    Pavani Kalluri
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Trop Med Int Health 11:49-55. 2006
    To evaluate SMART, Medicos Dip Stick and an Institut Pasteur (IP) cholera dipstick tests for accuracy and ease of use.
  57. ncbi Changing profile of Vibrio cholerae O1, O139 in Delhi & its periphery (2003-2005)
    N C Sharma
    Laboratory Department, Mharishi Valmiki Infectious Diseases Hospital, Delhi, India
    Indian J Med Res 125:633-40. 2007
    b>Cholera caused by either Vibrio cholerae O1 or O139 is endemic in Delhi and its peripheral areas. The present study was carried out to understand the changing epidemiology of V...
  58. ncbi [Mass antibiotic prophylaxis against cholera in the New Bell central prison in Douala during the 2004 epidemic]
    Edouard Guévart
    Coopération Française, Délégation provinciale de la santé publique du Littoral, BP 4012 Douala Cameroun
    Sante 15:225-7. 2005
    ..On 19 January, the provincial health authorities declared an outbreak of cholera. The epidemic lasted until that September...
  59. ncbi Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera
    N D Sonawane
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0521, USA
    FASEB J 20:130-2. 2006
    Enterotoxin-mediated secretory diarrheas such as cholera involve chloride secretion by enterocytes into the intestinal lumen by the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel...
  60. ncbi [Management of a cholera epidemic by a humanitarian organization]
    R Piarroux
    L Organisation Médecins du Monde, Paris, France
    Med Trop (Mars) 62:361-7. 2002
    Far from disappearing with modern progress, cholera outbreaks have never been more common than in the last decade...
  61. ncbi Short-chain fatty acids and commensal microbiota in the faeces of severely malnourished children with cholera rehydrated with three different carbohydrates
    S Monira
    International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
    Eur J Clin Nutr 64:1116-24. 2010
    ..to assess the number and proportion of faecal bacteria and the concentration of SCFAs of severely malnourished children with cholera receiving oral rehydration solution (ORS) containing glucose, amylase-resistant starch (ARS) or rice.
  62. ncbi Lipopolysaccharide- and cholera toxin-specific subclass distribution of B-cell responses in cholera
    F Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Diagn Lab Immunol 6:812-8. 1999
    The immunoglobulin subclass responses to homologous lipopolysaccharide (LPS) and to cholera toxin (CT) in adult patients infected with Vibrio cholerae O1 and V. cholerae O139 were studied...
  63. ncbi A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis
    C E Garner
    Clinical Science at South Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, UK
    Trans R Soc Trop Med Hyg 103:1171-3. 2009
    The aim of this pilot study was to analyse the volatile organic compounds in faecal samples collected from cholera patients in Bangladesh to determine biomarkers that could be used for disease diagnosis...
  64. ncbi Molecular typing of epidemic and nonepidemic Vibrio cholerae isolates and differentiation of V. cholerae and V. mimicus isolates by PCR-single-strand conformation polymorphism analysis
    F J Reen
    Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
    J Appl Microbiol 98:544-55. 2005
    ..cholerae and Vibrio mimicus isolates...
  65. ncbi [Choleriform diarrhea in children in Abdijan]
    J Enoh
    Arch Pediatr 10:1009-10. 2003
  66. ncbi Construction and evaluation of a safe, live, oral Vibrio cholerae vaccine candidate, IEM108
    Weili Liang
    Priority Laboratory of Medical Molecular Bacteriology, Ministry of Health, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, People's Republic of China
    Infect Immun 71:5498-504. 2003
    IEM101, a Vibrio cholerae O1 El Tor Ogawa strain naturally deficient in CTXPhi, was previously selected as a live cholera vaccine candidate...
  67. ncbi Peak occurrences of ciguatera fish poisoning precede cholera outbreaks in Hong Kong
    L C Kwan
    Port Health Office, Hong Kong
    Epidemiol Infect 131:621-6. 2003
    ..Peak activity of CFP preceded peak activity of cholera in nine of the years except in 4 years (1990, 1991, 1992, 1996) where it was observed that the total number of ..
  68. ncbi Role of toll-like receptor 4 in the proinflammatory response to Vibrio cholerae O1 El tor strains deficient in production of cholera toxin and accessory toxins
    G Kenneth Haines
    Northwestern University, Dept of Microbiology Immunology, 303 E Chicago Avenue, Tarry 3 713, Chicago, IL 60611, USA
    Infect Immun 73:6157-64. 2005
    ..Morbidity is enhanced in C3H/HeJ mice, indicating that Toll-like receptor 4 is important for infection containment...
  69. ncbi Intra-family transmission of Vibrio cholerae during a cholera epidemic in rural south-southern Nigeria
    Ndifreke E Udonwa
    Family Medicine, University of Calabar Teaching Hospital, Calabar, Cross River, Nigeria
    Trop Doct 38:179-80. 2008
  70. ncbi A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains
    D K Karaolis
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 95:3134-9. 1998
    ..includes harmless aquatic strains as well as strains capable of causing epidemics and global pandemics of cholera. While investigating the relationship between pathogenic and nonpathogenic strains, we identified a chromosomal ..
  71. ncbi [Molecular epidemiology of Vibrio cholerae O-1 from outbreak and sporadic patients in Nagoya in 1989]
    M Mori
    Nagoya City Health Research Institute
    Kansenshogaku Zasshi 65:833-7. 1991
    Enterotoxigenic strains of Vibrio cholerae O-1 biotype eltor, isolated from three sporadic cases of cholera in Nagoya in 1989 and an outbreak of cholera in Nagoya in 1989 were analyzed for their similarities. All isolates of V...
  72. ncbi Multilocus sequence typing has better discriminatory ability for typing Vibrio cholerae than does pulsed-field gel electrophoresis and provides a measure of phylogenetic relatedness
    Mamuka Kotetishvili
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Microbiol 41:2191-6. 2003
    ..cholerae strains from other, nonepidemic serogroups, with a number of tcpA and ctxAB alleles identified...
  73. ncbi [Cholera]
    Tatsuo Yamamoto
    Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
    Nippon Rinsho 61:801-10. 2003
  74. ncbi Use of telemedicine in evading cholera outbreak in Mahakumbh Mela, Prayag, UP, India: an encouraging experience
    A Ayyagari
    Department of Microbiology, SGPGIMS, Lucknow, India
    Telemed J E Health 9:89-94. 2003
    ..Subsequently, the number of diarrhea cases decreased considerably in a matter of a few days, and thus an epidemic disaster was averted, which could have created havoc in such a large gathering...
  75. ncbi Genetic and phenotypic diversity of quorum-sensing systems in clinical and environmental isolates of Vibrio cholerae
    Adam Joelsson
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Infect Immun 74:1141-7. 2006
    Vibrio cholerae is the causative agent of cholera, a severe and devastating diarrheal disease. V. cholerae lives naturally in various aquatic habitats during interepidemic periods...
  76. ncbi Process development for a Cuban cholera vaccine based on the attenuated strain Vibrio cholerae 638
    A Talavera
    Finlay Institute, 27 Ave, 19805 La Lisa, Ciudad de La Habana, A P 16017, Cod 11600, Cuba
    Vaccine 24:3746-9. 2006
    ..the work reported herein was to describe the process development methods for the production of the 638 attenuated cholera vaccine. Cell seed bank, culture of biomass, lyophilization and final formulation were processes were developed...
  77. ncbi Molecular-genetic peculiarities of classical biotype Vibrio cholerae, the etiological agent of the last outbreak Asiatic cholera in Russia
    Nina I Smirnova
    Laboratory of Pathogenic Vibrios, Russian Antiplague Research Institute Microbe, Universitetskaya St, 46, 410005, Saratov, Russia
    Microb Pathog 36:131-9. 2004
    Molecular-genetic properties of classical biotype Vibrio cholerae strains that caused the Asiatic cholera outbreak in 1942 in Russia have been investigated for the first time...
  78. ncbi Effectiveness of mass oral cholera vaccination in Beira, Mozambique
    Marcelino E S Lucas
    Ministry of Health, Maputo, Mozambique
    N Engl J Med 352:757-67. 2005
    BACKGROUND: New-generation, orally administered cholera vaccines offer the promise of improved control of cholera in sub-Saharan Africa...
  79. ncbi Variation of toxigenic Vibrio cholerae O1 in the aquatic environment of Bangladesh and its correlation with the clinical strains
    Mohammad Sirajul Islam
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Microbiol Immunol 48:773-7. 2004
    ..These findings suggest that the study of the molecular ecology of V. cholerae O1 in relation to its environmental reservoir is important in identifying virulent strains that cause disease...
  80. ncbi Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles
    Yvonne A O'Shea
    Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
    J Clin Microbiol 42:4657-71. 2004
    Vibrio cholerae, the causative agent of cholera, is a natural inhabitant of the aquatic ecosystem. We examined a unique collection of V...
  81. ncbi [Excess mortality by diarrhea simultaneous to a cholera epidemic in Northeastern Brazil]
    Moacir Gerolomo
    Fundacao Nacional de Saude, Ministerio da Saude, Curitiba, PR, Brazil
    Rev Saude Publica 38:517-21. 2004
    ..To evaluate excess mortality due to infectious diarrhea without etiological diagnosis, occurring simultaneously to Vibrio cholerae circulation...
  82. ncbi Experimental immunisation and protection of guinea pigs with Vibrio cholerae toxoid and mucinases, neuraminidase and proteinase
    Duncan E S Stewart-Tull
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Vaccine 22:2137-45. 2004
    ..Animals injected intramuscularly (i.m.) with toxoid-containing vaccines were protected from challenge with cholera toxin (CT) whereas those given oral doses were not. Toxoid plus killed V...
  83. ncbi Construction and characterization of a thyA mutant derived from cholera vaccine candidate IEM101
    Fenggang Yu
    National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, People's Republic of China
    Mol Biotechnol 29:191-6. 2005
    A naturally cholera toxin gene negative Vibrio cholerae (O1, El Tor, Ogawa) strain, named IEM101, was isolated in China...
  84. ncbi Cholera outbreaks continue
    Erica Weir
    Division of Infectious Diseases, McMaster University Medical Centre, Hamilton, Ont
    CMAJ 170:1092-3. 2004
  85. ncbi Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 102:6119-24. 2005
    Phage predation of Vibrio cholerae has recently been reported to be a factor that influences seasonal epidemics of cholera in Bangladesh. To understand more about this phenomenon, we studied the dynamics of the V...
  86. ncbi All phaged out
    N Williams
    Curr Biol 15:R318-9. 2005
  87. ncbi Prevention of cholera
    Noel W Preston
    Lancet 363:898. 2004
  88. ncbi Molecular characterisation of rough strains of Vibrio cholerae isolated from diarrhoeal cases in India and their comparison to smooth strains
    Keya De
    Division of Microbiology, National Institute of Cholera and Enteric Diseases, P33 CIT Road, Scheme XM, Kolkata 700 010, India
    FEMS Microbiol Lett 232:23-30. 2004
    ..Expression of the regulatory element ToxR was evident in these strains. Cholera toxin production ability of the rough strains was found to be higher (c...
  89. ncbi Role of exopolysaccharide, the rugose phenotype and VpsR in the pathogenesis of epidemic Vibrio cholerae
    Mohammed H Rashid
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FEMS Microbiol Lett 230:105-13. 2004
    Vibrio cholerae, the causative agent of cholera can produce an exopolysaccharide (EPS)...
  90. ncbi Outbreak of cholera in & around Chandigarh during two successive years (2002, 2003)
    Neelam Kaistha
    Department of Microbiology, Government Medical College and Hospital, Chandigarh, India
    Indian J Med Res 122:404-7. 2005
    Outbreaks of cholera caused by Vibrio cholerae O1 Ogawa occurred in and around Chandigarh during two successive year 2002 and 2003. This study highlights the antibiotic sensitivity and phage typing pattern of V...
  91. ncbi Seasonal cholera from multiple small outbreaks, rural Bangladesh
    O Colin Stine
    University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Emerg Infect Dis 14:831-3. 2008
    ..The observed minimal overlap in VNTR patterns between the 2 communities was consistent with sequential, small outbreaks from local sources...
  92. ncbi Molecular epidemiological studies of Vibrio cholerae in Bengal region
    Sumio Shinoda
    Faculty of Science, Okayama University of Science, Ridai cho, Okayama 700 0005, Japan
    Biocontrol Sci 13:1-8. 2008
    Vibrio cholerae isolates from environmental and clinical origins in the Bengal region in which epidemics of cholera break out periodically were analyzed with particular emphasis on the molecular epidemiological features...
  93. ncbi Concomitant infection of enterotoxigenic Escherichia coli in an outbreak of cholera caused by Vibrio cholerae O1 and O139 in Ahmedabad, India
    S Chakraborty
    National Institute of Cholera and Enteric Diseases, Calcutta, India
    J Clin Microbiol 39:3241-6. 2001
    ..cholerae O1 and O139 isolates examined harbored the ctxA gene (encoding the A subunit of cholera toxin) and the El Tor variant of the tcpA gene (encoding toxin-coregulated pilus)...
  94. ncbi Comparison of antibiogram, virulence genes, ribotypes and DNA fingerprints of Vibrio cholerae of matching serogroups isolated from hospitalised diarrhoea cases and from the environment during 1997-1998 in Calcutta, India
    S Chakraborty
    National Institute of Cholera and Enteric Diseases, Beliaghata, Calcutta, India
    J Med Microbiol 50:879-88. 2001
    ..cases and from the environment during a concurrent clinical and environmental study conducted in Calcutta, a cholera endemic area...
  95. ncbi Epidemic and endemic cholera trends over a 33-year period in Bangladesh
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Infect Dis 186:246-51. 2002
    Despite nearly 200 years of study, the mechanisms contributing to the maintenance of endemic cholera and the causes of periodic epidemics remain poorly understood...
  96. ncbi Evidence for a clonally different origin of the two cholera epidemics of 2001-2002 and 1980-1987 in South Africa
    Karen H Keddy
    Enteric Diseases Reference Unit, National Institute for Communicable Diseases University of the Witwatersrand, Johannesburg, South Africa
    J Med Microbiol 56:1644-50. 2007
    Vibrio cholerae O1 serotype Ogawa and serotype Inaba isolates from the cholera epidemic that occurred in 2001 and 2002 in South Africa were compared with isolates of V...
  97. ncbi Cholera in Indonesia in 1993-1999
    C H Simanjuntak
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    Am J Trop Med Hyg 65:788-97. 2001
    b>Cholera-specific surveillance in Indonesia was initiated to identify the introduction of the newly recognized Vibrio cholerae non-O1, O139 serotype...
  98. ncbi Wind direction and its linkage with Vibrio cholerae dissemination
    Shlomit Paz
    Department of Geography and Environmental Studies, University of Haifa, Haifa, Israel
    Environ Health Perspect 115:195-200. 2007
    The relevance of climatic events as causative factors for cholera epidemics is well known. However, examinations of the involvement of climatic factors in intracontinental disease distribution are still absent.
  99. ncbi Occurrence, significance & molecular epidemiology of cholera outbreaks in West Bengal
    Dipika Sur
    National Institute of Cholera and Enteric Diseases ICMR, Kolkata, India
    Indian J Med Res 125:772-6. 2007
    ..We carried out investigation of two cholera outbreaks, for identification, antimicrobial susceptibility testing, phage typing and molecular characterization ..
  100. ncbi Incidence and molecular analysis of Vibrio cholerae associated with cholera outbreak subsequent to the super cyclone in Orissa, India
    G P Chhotray
    Department of Microbiology and Pathology, Regional Medical Research Centre (I. C. M. R, Bhubaneswar, Orissa, India
    Epidemiol Infect 128:131-8. 2002
    ..Drinking water scarcity and poor sanitation were thought to be responsible for these diarrhoeal outbreaks. Timely reporting and implementation of appropriate control measures could contain a vital epidemic in this area...
  101. ncbi Molecular ecology of toxigenic Vibrio cholerae
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Microbiol Immunol 46:59-66. 2002
    Toxigenic Vibrio cholerae is the etiological agent of cholera, an acute dehydrating diarrhea that occurs in epidemic form in many developing countries. Although V...

Research Grants92

  1. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall K Holmes; Fiscal Year: 2010
    About 4 billion cases of diarrhea occur annually and cause 4% of all deaths worldwide. Cholera caused by Vibrio cholerae and watery diarrhea caused by enterotoxigenic Escherichia coli (ETEC) cause substantial morbidity and mortality ..
  2. EPIDEMIOLOGY & ECOLOGY OF VIBRIO CHOLERAE IN BANGLADESH
    Richard Sack; Fiscal Year: 2000
    DESCRIPTION: (Adapted from Applicant's Abstract). Cholera, the most severe of all diarrheal diseases, caused by Vibrio cholerae 01 (and most recently also by serogroup 0139) is one of the few pandemic infections of man...
  3. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2007
    About 4 billion cases of diarrhea occur annually and cause 4% of all deaths worldwide. Cholera caused by Vibrio cholerae and watery diarrhea caused by enterotoxigenic Escherichia coli (ETEC) cause substantial morbidity and mortality ..
  4. Study of transmissible forms of Vibrio cholerae
    Andrew Camilli; Fiscal Year: 2007
    ..with plankton in brackish, temperate waters the world over, is the causative agent of endemic and epidemic cholera. Hallmarks of the disease include prodigious watery diarrhea resulting from the action of secreted cholera toxin (..
  5. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Cholera, and related diarrheal diseases, are the #3 cause of all deaths worldwide...
  6. PERTUSSIS, DIPHTHERIA, CHOLERA TOXINS--INHIBITOR DESIGN
    Vern Schramm; Fiscal Year: 1993
    Pertussis, diphtheria and cholera infections affect an estimated 100 million people each year with an estimated 1 million fatalities. Recently, local epidemics have occurred...
  7. Epidemiology and Ecology of Vibrio cholerae in Bangladesh
    Richard Bradley Sack; Fiscal Year: 2010
    DESCRIPTION (provided by investigator): Cholera, caused by Vibrio cholerae serogroups O1 and O139, is the most severe of diarrheal diseases and continues to cause significant morbidity and mortality throughout the developing world...
  8. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2010
    ..We used cholera toxin and developed novel derivatives lacking ADP ribosyl transferase activity to circumvent the reactogenicity ..
  9. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2011
    ..We used cholera toxin and developed novel derivatives lacking ADP ribosyl transferase activity to circumvent the reactogenicity ..
  10. A Screen for Small Molecule Compounds that Inhibit Bacterial Toxins
    David Haslam; Fiscal Year: 2007
    Shiga toxin (Stx), cholera toxin (Ctx) and ricin are important mediators of human disease and are potential agents of biowarfare. These toxins follow a complex intracellular pathway in order to kill susceptible cells...
  11. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2006
    ..billion cases of diarrhea cause 4 million deaths annually in children under 5 years old, and 5-7 million cases of cholera cause about 100,000 deaths. Cholera toxin (CT) from Vibrio cholerae causes the massive watery diarrhea of cholera...
  12. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2005
    ..billion cases of diarrhea cause 4 million deaths annually in children under 5 years old, and 5-7 million cases of cholera cause about100,000 deaths. Cholera toxin (CT) from Vibrio cholerae causes the massive watery diarrhea of cholera...
  13. ADP RIBOSYLATION OF A POTENT INDUCER OF PROLIFERATION
    Mark Francis; Fiscal Year: 2002
    ..Based on his previous work, the applicant hypothesizes that cholera toxin ADP-ribosylates a non-Gs protein that regulates B cell activation...
  14. Genetic and Biochemical Study of V. cholerae RTX Toxin
    Karla J F Satchell; Fiscal Year: 2010
    Abstract The life-threatening diarrheal disease cholera is caused by toxigenic strains of the Gram-negative organism Vibrio cholerae. In addition to the well-characterized ADP-ribosylating cholera toxin (CT), V...
  15. Genetic and Biochemical Study of V. cholerae RTX Toxin
    Karla J F Satchell; Fiscal Year: 2010
    The life-threatening diarrheal disease cholera is caused by toxigenic strains of the Gram-negative organism Vibrio cholerae. In addition to the well-characterized ADP-ribosylating cholera toxin (CT), V...
  16. ACCESSORY CHOLERA ENTEROTOXIN, ACE, MECHANISM OF ACTION
    Michele Trucksis; Fiscal Year: 2006
    Colonization of the small intestine by Vibrio cholerae causes the potentially lethal disease cholera due to massive salt and water secretion...
  17. POPULATION BIOLOGY OF SURFACE POLYSACCHARIDES IN CHOLERA
    John Morris; Fiscal Year: 2004
    b>Cholera is an ancient disease in the midst of a modern resurgence, with cases reported to WHO by 65 member nations in Asia, Africa, the Americas, and Europe in 1997. With the appearance of V...
  18. Retro-translocation of cholera toxin in intestinal cells: from ER to cytosol
    NAOMI WERNICK; Fiscal Year: 2007
    The goal of this application is to elucidate the molecular basis for retro-translocation of the cholera toxin (CT) A1-chain from within the lumen of the endoplasmic reticulum (ER) to the cytosol...
  19. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David Saslowsky; Fiscal Year: 2007
    ..b>Cholera toxin (CT), the causative agent of Asiatic cholera, typifies the structure and function of the AB5-subunit toxins ..