cholera

Summary

Summary: An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.

Top Publications

  1. pmc The origin of the Haitian cholera outbreak strain
    Chen Shan Chin
    Pacific Biosciences, Menlo Park, CA, USA
    N Engl J Med 364:33-42. 2011
  2. pmc Evidence for several waves of global transmission in the seventh cholera pandemic
    Ankur Mutreja
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 477:462-5. 2011
  3. ncbi Cholera
    David A Sack
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Dhaka, Bangladesh
    Lancet 363:223-33. 2004
  4. pmc Quorum-sensing regulators control virulence gene expression in Vibrio cholerae
    Jun Zhu
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3129-34. 2002
  5. pmc Population genetics of Vibrio cholerae from Nepal in 2010: evidence on the origin of the Haitian outbreak
    Rene S Hendriksen
    National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark
    MBio 2:e00157-11. 2011
  6. pmc Genomic diversity of 2010 Haitian cholera outbreak strains
    Nur A Hasan
    Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 109:E2010-7. 2012
  7. doi Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Lancet 374:1694-702. 2009
  8. pmc Effects of global climate on infectious disease: the cholera model
    Erin K Lipp
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Clin Microbiol Rev 15:757-70. 2002
  9. doi Evolution of new variants of Vibrio cholerae O1
    Ashrafus Safa
    Department of Biology and Chemistry and MERIT, City University of Hong Kong, 83, Tat Chee Avenue, Kowloon Tong, Kowloon, Hong Kong SAR
    Trends Microbiol 18:46-54. 2010
  10. ncbi Inapparent infections and cholera dynamics
    Aaron A King
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 454:877-80. 2008

Detail Information

Publications313 found, 100 shown here

  1. pmc The origin of the Haitian cholera outbreak strain
    Chen Shan Chin
    Pacific Biosciences, Menlo Park, CA, USA
    N Engl J Med 364:33-42. 2011
    Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera in Haiti.
  2. pmc Evidence for several waves of global transmission in the seventh cholera pandemic
    Ankur Mutreja
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 477:462-5. 2011
    ..a globally important pathogen that is endemic in many areas of the world and causes 3-5 million reported cases of cholera every year...
  3. ncbi Cholera
    David A Sack
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Dhaka, Bangladesh
    Lancet 363:223-33. 2004
    ..Without adequate and appropriate rehydration therapy, severe cholera kills about half of affected individuals...
  4. pmc Quorum-sensing regulators control virulence gene expression in Vibrio cholerae
    Jun Zhu
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3129-34. 2002
    The production of virulence factors including cholera toxin and the toxin-coregulated pilus in the human pathogen Vibrio cholerae is strongly influenced by environmental conditions...
  5. pmc Population genetics of Vibrio cholerae from Nepal in 2010: evidence on the origin of the Haitian outbreak
    Rene S Hendriksen
    National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark
    MBio 2:e00157-11. 2011
    b>Cholera continues to be an important cause of human infections, and outbreaks are often observed after natural disasters, such as the one following the 2010 earthquake in Haiti...
  6. pmc Genomic diversity of 2010 Haitian cholera outbreak strains
    Nur A Hasan
    Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 109:E2010-7. 2012
    The millions of deaths from cholera during the past 200 y, coupled with the morbidity and mortality of cholera in Haiti since October 2010, are grim reminders that Vibrio cholerae, the etiologic agent of cholera, remains a scourge...
  7. doi Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Lancet 374:1694-702. 2009
    Oral cholera vaccines consisting of killed whole cells have been available for many years, but they have not been used extensively in populations with endemic disease...
  8. pmc Effects of global climate on infectious disease: the cholera model
    Erin K Lipp
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Clin Microbiol Rev 15:757-70. 2002
    ..b>Cholera, caused by Vibrio cholerae, lends itself to analyses of the role of climate in infectious disease, coupled to ..
  9. doi Evolution of new variants of Vibrio cholerae O1
    Ashrafus Safa
    Department of Biology and Chemistry and MERIT, City University of Hong Kong, 83, Tat Chee Avenue, Kowloon Tong, Kowloon, Hong Kong SAR
    Trends Microbiol 18:46-54. 2010
    Vibrio cholerae typically contains a prophage that carries the genes encoding the cholera toxin, which is responsible for the major clinical symptoms of the disease. In recent years, new pathogenic variants of V...
  10. ncbi Inapparent infections and cholera dynamics
    Aaron A King
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 454:877-80. 2008
    ..This is true for cholera, a pandemic bacterial disease, where estimates of the ratio of asymptomatic to symptomatic infections have ranged ..
  11. ncbi El Tor cholera with severe disease: a new threat to Asia and beyond
    A K Siddique
    Public Health Sciences Division PHSD, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Epidemiol Infect 138:347-52. 2010
    During epidemics of cholera in two rural sites (Bakerganj and Mathbaria), a much higher proportion of patients came for treatment with severe dehydration than was seen in previous years. V...
  12. pmc Regional-scale climate-variability synchrony of cholera epidemics in West Africa
    Guillaume Constantin de Magny
    Génétique et Evolution des Maladies Infectieuses, UMR CNRS IRD 2724, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 05, France
    BMC Infect Dis 7:20. 2007
    The relationship between cholera and climate was explored in Africa, the continent with the most reported cases, by analyzing monthly 20-year cholera time series for five coastal adjoining West African countries: Côte d'Ivoire, Ghana, ..
  13. pmc The global burden of cholera
    Mohammad Ali
    International Vaccine Institute, SNU Research Park, Seoul, Republic of Korea
    Bull World Health Organ 90:209-218A. 2012
    To estimate the global burden of cholera using population-based incidence data and reports.
  14. doi Oral vaccines against cholera
    Sunheang Shin
    International Vaccine Institute, Seoul, South Korea
    Clin Infect Dis 52:1343-9. 2011
    The current seventh pandemic of cholera, caused by serogroup O1, El Tor biotype, has now involved almost the entire developing world...
  15. pmc One-step immunochromatographic dipstick tests for rapid detection of Vibrio cholerae O1 and O139 in stool samples
    F Nato
    Institut Pasteur, Paris, France
    Clin Diagn Lab Immunol 10:476-8. 2003
    ..The sensitivity of the dipsticks ranged from 94.2 to 100% when evaluated with stool samples obtained in Madagascar and Bangladesh. The dipstick can provide a simple tool for epidemiological surveys...
  16. pmc Field evaluation of a rapid immunochromatographic dipstick test for the diagnosis of cholera in a high-risk population
    Xuan Yi Wang
    The International Vaccine Institute, Seoul, Korea
    BMC Infect Dis 6:17. 2006
    Early detection of cholera outbreaks is crucial for the implementation of the most appropriate control strategies.
  17. pmc Lessons learned during public health response to cholera epidemic in Haiti and the Dominican Republic
    Jordan W Tappero
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:2087-93. 2011
    After epidemic cholera emerged in Haiti in October 2010, the disease spread rapidly in a country devastated by an earthquake earlier that year, in a population with a high proportion of infant deaths, poor nutrition, and frequent ..
  18. pmc The case for reactive mass oral cholera vaccinations
    Rita Reyburn
    International Vaccine Institute IVI, Seoul, Korea
    PLoS Negl Trop Dis 5:e952. 2011
    The outbreak of cholera in Zimbabwe intensified interest in the control and prevention of cholera...
  19. pmc Immunization with Vibrio cholerae outer membrane vesicles induces protective immunity in mice
    Stefan Schild
    Department of Molecular Biology and Microbiology, Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Infect Immun 76:4554-63. 2008
    ..These findings may contribute to the development of "nonliving," OMV-based vaccines against V. cholerae and other enteric pathogens, using the oral or intranasal route of immunization...
  20. ncbi Is cholera disease associated with poverty?
    Arturo Talavera
    Finlay Institute, Havana, Cuba
    J Infect Dev Ctries 3:408-11. 2009
    b>Cholera remains a global threat and is one of the key indicators of social development...
  21. pmc Social and news media enable estimation of epidemiological patterns early in the 2010 Haitian cholera outbreak
    Rumi Chunara
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Am J Trop Med Hyg 86:39-45. 2012
    ..We assessed correlation of volume of cholera-related HealthMap news media reports, Twitter postings, and government cholera cases reported in the first 100 ..
  22. doi Cholera epidemic in Haiti, 2010: using a transmission model to explain spatial spread of disease and identify optimal control interventions
    Ashleigh R Tuite
    Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada
    Ann Intern Med 154:593-601. 2011
    Haiti is in the midst of a cholera epidemic. Surveillance data for formulating models of the epidemic are limited, but such models can aid understanding of epidemic processes and help define control strategies.
  23. pmc Molecular evidence of cholera outbreak caused by a toxigenic Vibrio cholerae O1 El tor variant strain in Kelantan, Malaysia
    Geik Yong Ang
    Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia
    J Clin Microbiol 48:3963-9. 2010
    A total of 20 Vibrio cholerae isolates were recovered for investigation from a cholera outbreak in Kelantan, Malaysia, that occurred between November and December 2009. All isolates were biochemically characterized as V...
  24. pmc Vibrio cholerae pathogenic clones
    Anna Salim
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Emerg Infect Dis 11:1758-60. 2005
    ..The sixth pandemic clone was well separated from them...
  25. pmc Diagnostic limitations to accurate diagnosis of cholera
    Munirul Alam
    Enteric and Food Microbiology Laboratory, Laboratory Sciences Division, International Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
    J Clin Microbiol 48:3918-22. 2010
    ..showed Vibrio cholerae to be the predominant cause, although more than 40% of the suspected cases failed to show cholera etiology by conventional culture methods (CMs)...
  26. pmc Transmission dynamics and control of cholera in Haiti: an epidemic model
    Jason R Andrews
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet 377:1248-55. 2011
    Official projections of the cholera epidemic in Haiti have not incorporated existing disease trends or patterns of transmission, and proposed interventions have been debated without comparative estimates of their effect...
  27. doi Severe diarrhea caused by cholera toxin-producing vibrio cholerae serogroup O75 infections acquired in the southeastern United States
    Melissa Tobin-D'Angelo
    Georgia Division of Public Health, Atlanta, Georgia 30303, USA
    Clin Infect Dis 47:1035-40. 2008
    From 2003 through 2007, Vibrio cholerae serogroup O75 strains possessing the cholera toxin gene were isolated from 6 patients with severe diarrhea, including 3 in Georgia, 2 in Alabama, and 1 in South Carolina...
  28. doi Global impact of Vibrio cholerae interactions with chitin
    Carla Pruzzo
    Dipartimento di Biologia, Universita di Genova, Corso Europa 26, 16132 Genova, Italy
    Environ Microbiol 10:1400-10. 2008
    ..cholerae interactions with chitin represent a useful model for examination of the role of primary habitat selection in the development of traits that have been identified as virulence factors in human disease...
  29. pmc Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles
    Yvonne A O'Shea
    Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
    J Clin Microbiol 42:4657-71. 2004
    Vibrio cholerae, the causative agent of cholera, is a natural inhabitant of the aquatic ecosystem. We examined a unique collection of V...
  30. pmc Efficacy of a low-cost, inactivated whole-cell oral cholera vaccine: results from 3 years of follow-up of a randomized, controlled trial
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    PLoS Negl Trop Dis 5:e1289. 2011
    Killed oral cholera vaccines (OCVs) have been licensed for use in developing countries, but protection conferred by licensed OCVs beyond two years of follow-up has not been demonstrated in randomized, clinical trials.
  31. ncbi Evaluation of three rapid diagnostic tests for cholera: does the skill level of the technician matter?
    Pavani Kalluri
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Trop Med Int Health 11:49-55. 2006
    To evaluate SMART, Medicos Dip Stick and an Institut Pasteur (IP) cholera dipstick tests for accuracy and ease of use.
  32. pmc Use of dipsticks for rapid diagnosis of cholera caused by Vibrio cholerae O1 and O139 from rectal swabs
    N A Bhuiyan
    Laboratory and Clinical Sciences Divisions, International Centre for Diarrhoeal Diseases Research, Bangladesh ICDDR, B, Dhaka 1212, Bangladesh
    J Clin Microbiol 41:3939-41. 2003
    ..The dipsticks represent the first rapid test which has been successfully used to diagnose cholera from rectal swabs, and this would immensely improve surveillance for cholera, especially in remote settings.
  33. pmc Identification of host cell factors required for intoxication through use of modified cholera toxin
    Carla P Guimaraes
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Biol 195:751-64. 2011
    ..to site-specifically attach fluorophores, biotin, and proteins to the C terminus of the A1 subunit (CTA1) of cholera toxin (CTx) in an otherwise correctly assembled and active CTx complex...
  34. pmc Vibrio cholerae O1 hybrid El Tor strains, Asia and Africa
    Ashrafus Safa
    Emerg Infect Dis 14:987-8. 2008
  35. pmc Environmental signatures associated with cholera epidemics
    Guillaume Constantin de Magny
    Institute for Advanced Computer Studies, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 105:17676-81. 2008
    The causative agent of cholera, Vibrio cholerae, has been shown to be autochthonous to riverine, estuarine, and coastal waters along with its host, the copepod, a significant member of the zooplankton community...
  36. ncbi Association between climate variability and hospital visits for non-cholera diarrhoea in Bangladesh: effects and vulnerable groups
    Masahiro Hashizume
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 36:1030-7. 2007
    We estimated the effects of rainfall and temperature on the number of non-cholera diarrhoea cases and identified population factors potentially affecting vulnerability to the effect of the climate factors in Dhaka, Bangladesh.
  37. pmc Cholera outbreaks caused by an altered Vibrio cholerae O1 El Tor biotype strain producing classical cholera toxin B in Vietnam in 2007 to 2008
    Binh Minh Nguyen
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Clin Microbiol 47:1568-71. 2009
    Vibrio cholerae O1 isolates collected during cholera outbreaks occurring from late 2007 to early 2008 in northern Vietnam were revealed to represent an altered strain containing the RS1 element followed by a CTX prophage harboring El Tor ..
  38. ncbi Vibrio cholerae and cholera: out of the water and into the host
    Joachim Reidl
    Zentrum für Infektionsforschung, Universitat Wurzburg, Wurzburg, Germany
    FEMS Microbiol Rev 26:125-39. 2002
    ..V. cholerae is well recognized and extensively studied as the causative agent of the human intestinal disease cholera. In former centuries cholera was a permanent threat even to the highly developed populations of Europe, North ..
  39. pmc Incidence, virulence factors, and clonality among clinical strains of non-O1, non-O139 Vibrio cholerae isolates from hospitalized diarrheal patients in Kolkata, India
    S Chatterjee
    National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India
    J Clin Microbiol 47:1087-95. 2009
    ..The non-O1, non-O139 strains were nontoxigenic except for an O36 strain (SC124), which regulated expression of cholera toxin as O1 classical strains did...
  40. pmc Controlling endemic cholera with oral vaccines
    Ira M Longini
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e336. 2007
    Although advances in rehydration therapy have made cholera a treatable disease with low case-fatality in settings with appropriate medical care, cholera continues to impose considerable mortality in the world's most impoverished ..
  41. doi Cholera in Bangladesh: climatic components of seasonal variation
    Masahiro Hashizume
    Department of International Health, Institute of Tropical Medicine NEKKEN, The Global Center of Excellence program, Nagasaki University, Nagasaki, Japan
    Epidemiology 21:706-10. 2010
    The mechanisms underlying the seasonality of cholera are still not fully understood, despite long-standing recognition of clear bimodal seasonality in Bangladesh...
  42. pmc Characterization of Vibrio cholerae outer membrane vesicles as a candidate vaccine for cholera
    Stefan Schild
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Infect Immun 77:472-84. 2009
    Outer membrane vesicles (OMVs) offer a new approach for an effective cholera vaccine...
  43. ncbi Field evaluation of crystal VC Rapid Dipstick test for cholera during a cholera outbreak in Guinea-Bissau
    Julie R Harris
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Trop Med Int Health 14:1117-21. 2009
    ..To evaluate performance characteristics and ease of use of the new commercially available Crystal VC Rapid Dipstick (VC) test (Span Diagnostics, India) for Vibrio cholerae O1 and O139...
  44. ncbi Evaluation of a rapid immunochromatographic dipstick kit for diagnosis of cholera emphasizes its outbreak utility
    Piyali Mukherjee
    Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Jpn J Infect Dis 63:234-8. 2010
    ..This dipstick test has the potential to act as an early warning system for cholera in many developing countries, especially during the start of an outbreak, which would ultimately lead to a ..
  45. pmc The burden of cholera in the slums of Kolkata, India: data from a prospective, community based study
    D Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Arch Dis Child 90:1175-81. 2005
    ..based study in an impoverished urban site in Kolkata (formerly Calcutta) in order to measure the burden of cholera, describe its epidemiology, and search for potential risk factors that could be addressed by public health ..
  46. pmc New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 40:3296-9. 2002
    The sixth pandemic of cholera and, presumably, the earlier pandemics were caused by the classical biotype of Vibrio cholerae O1, which was progressively replaced by the El Tor biotype representing the seventh cholera pandemic...
  47. pmc Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 44:4211-3. 2006
    We determined the types of cholera toxin (CT) produced by a collection of 185 Vibrio cholerae O1 strains isolated in Bangladesh over the past 45 years. All of the El Tor strains of V...
  48. pmc Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae
    Ok S Shin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    MBio 2:e00106-11. 2011
    b>Cholera is a severe diarrheal disease typically caused by O1 serogroup strains of Vibrio cholerae. The pathogenicity of all pandemic V...
  49. pmc Mass vaccination with a two-dose oral cholera vaccine in a refugee camp
    D Legros
    Epicentre, Kampala, Uganda
    Bull World Health Organ 77:837-42. 1999
    In refugee settings, the use of cholera vaccines is controversial since a mass vaccination campaign might disrupt other priority interventions...
  50. pmc Investigation of the roles of toxin-coregulated pili and mannose-sensitive hemagglutinin pili in the pathogenesis of Vibrio cholerae O139 infection
    C O Tacket
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 66:692-5. 1998
    ..01). We conclude that TCP are an important colonization factor of V. cholerae O139 and probably of El Tor V. cholerae O1. In contrast, MSHA does not appear to promote intestinal colonization in humans...
  51. pmc Vaccination strategies for epidemic cholera in Haiti with implications for the developing world
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 108:7081-5. 2011
    In October 2010, a virulent South Asian strain of El Tor cholera began to spread in Haiti. Interventions have included treatment of cases and improved sanitation...
  52. doi A rapid, simple, and sensitive loop-mediated isothermal amplification method to detect toxigenic Vibrio cholerae in rectal swab samples
    Kazuhisa Okada
    Thailand Japan Research Collaboration Center on Emerging and Reemerging Infections, DMSc, Ministry of Public Health, Nonthaburi, Thailand
    Diagn Microbiol Infect Dis 66:135-9. 2010
    ..54 CFU/reaction. The method was applied to rectal swab samples from cholera patients and healthy volunteers (19 subjects each) and yielded the same results as the "gold standard" culture ..
  53. doi Cholera: a great global concern
    Shyamapada Mandal
    Department of Zoology, Gurudas College, Narkeldanga, Kolkata 700 054, India
    Asian Pac J Trop Med 4:573-80. 2011
    b>Cholera, caused by the infection of toxigenic Vibrio cholerae (V. cholerae) to humans, is a life threatening diarrheal disease with epidemic and pandemic potential. The V...
  54. pmc Spatially selective colonization of the arthropod intestine through activation of Vibrio cholerae biofilm formation
    Alexandra E Purdy
    Division of Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:19737-42. 2011
    Vibrio cholerae is an estuarine bacterium and the human pathogen responsible for the diarrheal disease cholera. In the environment, arthropods are proposed to be carriers and reservoirs of V. cholerae...
  55. pmc Evidence of a dominant lineage of Vibrio cholerae-specific lytic bacteriophages shed by cholera patients over a 10-year period in Dhaka, Bangladesh
    Kimberley D Seed
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    MBio 2:e00334-10. 2011
    Lytic bacteriophages are hypothesized to contribute to the seasonality and duration of cholera epidemics in Bangladesh. However, the bacteriophages contributing to this phenomenon have yet to be characterized at a molecular genetic level...
  56. pmc The costs of climate change: a study of cholera in Tanzania
    Sara L M Trærup
    UNEP Risø Centre, Risø DTU, P O Box 49, 4000 Roskilde, Denmark
    Int J Environ Res Public Health 8:4386-405. 2011
    ..This study integrates historical data on temperature and rainfall with the burden of disease from cholera in Tanzania and uses socioeconomic data to control for the impacts of general development on the risk of cholera...
  57. ncbi Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae
    D Scott Merrell
    Tufts University School of Medicine, Department of Molecular Biology and Microbiology, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Microbiol 43:1471-91. 2002
    ..While cholera toxin and the toxin-coregulated pilus (TCP) are known to be essential for full virulence, the role that other ..
  58. ncbi A recombinant probiotic for treatment and prevention of cholera
    Antonio Focareta
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia
    Gastroenterology 130:1688-95. 2006
    ..In the present study, this has been applied to the development of a recombinant probiotic for treatment and prevention of cholera, caused by Vibrio cholerae.
  59. doi Genetic determinants of virulence, antibiogram and altered biotype among the Vibrio cholerae O1 isolates from different cholera outbreaks in India
    A K Goel
    Biotechnology Division, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Infect Genet Evol 10:815-9. 2010
    b>Cholera diarrhea is still a major health challenge for a large part of globe...
  60. pmc Vibrio cholerae O139 in Calcutta, 1992-1998: incidence, antibiograms, and genotypes
    A Basu
    National Institute of Cholera and Enteric Diseases, Calcutta, India
    Emerg Infect Dis 6:139-47. 2000
    We report results of surveillance for cholera caused by Vibrio cholerae O139 from September 1992, when it was first identified, to December 1998. V...
  61. pmc Mechanism of Vibrio cholerae autoinducer-1 biosynthesis
    Yunzhou Wei
    Department of Molecular Biology and Department of Chemistry, Princeton University, New Jersey 08544, United States
    ACS Chem Biol 6:356-65. 2011
    Vibrio cholerae, the causative agent of the disease cholera, uses a cell to cell communication process called quorum sensing to control biofilm formation and virulence factor production. The major V...
  62. ncbi The tcp gene cluster of Vibrio cholerae
    P A Manning
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Gene 192:63-70. 1997
    ..Experiments using the infant mouse cholera model have now shown that TCP is a colonization factor and protective antigen for both classical and El Tor O1 ..
  63. ncbi Mechanism of drug resistance in a clinical isolate of Vibrio fluvialis: involvement of multiple plasmids and integrons
    Neha Rajpara
    Department of Human Health and Diseases, School of Biological Sciences and Biotechnology, Indian Institute of Advanced Research, Koba Institutional Area, Gandhinagar 382 007, Gujarat, India
    Int J Antimicrob Agents 34:220-5. 2009
    ..To the best of our knowledge, this is the first report of horizontal transfer of a plasmid between V. fluvialis and V. cholerae...
  64. pmc Dynamics of cholera outbreaks in Great Lakes region of Africa, 1978-2008
    Didier Bompangue Nkoko
    Universite de Franche Comte, Besancon, France
    Emerg Infect Dis 17:2026-34. 2011
    b>Cholera outbreaks have occurred in Burundi, Rwanda, Democratic Republic of Congo, Tanzania, Uganda, and Kenya almost every year since 1977-1978, when the disease emerged in these countries...
  65. pmc Warming oceans, phytoplankton, and river discharge: implications for cholera outbreaks
    Antarpreet S Jutla
    Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA
    Am J Trop Med Hyg 85:303-8. 2011
    ..has led to an assertion that in a warming climate, rise in SST may increase phytoplankton blooms and, therefore, cholera outbreaks...
  66. pmc Cholera in Haiti and other Caribbean regions, 19th century
    Deborah Jenson
    Duke University, Durham, North Carolina 27708, USA
    Emerg Infect Dis 17:2130-5. 2011
    Medical journals and other sources do not show evidence that cholera occurred in Haiti before 2010, despite the devastating effect of this disease in the Caribbean region in the 19th century...
  67. pmc Local population and regional environmental drivers of cholera in Bangladesh
    Michael Emch
    Department of Geography, University of North Carolina Chapel Hill, USA
    Environ Health 9:2. 2010
    Regional environmental factors have been shown to be related to cholera. Previous work in Bangladesh found that temporal patterns of cholera are positively related to satellite-derived environmental variables including ocean chlorophyll ..
  68. pmc Improving community coverage of oral cholera mass vaccination campaigns: lessons learned in Zanzibar
    Christian Schaetti
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e41527. 2012
    Recent research in two cholera-endemic communities of Zanzibar has shown that a majority (∼94%) of the adult population was willing to receive free oral cholera vaccines (OCVs)...
  69. pmc Cholera epidemic in Guinea-Bissau (2008): the importance of "place"
    Francisco J Luquero
    Epicentre, Paris, France
    PLoS ONE 6:e19005. 2011
    As resources are limited when responding to cholera outbreaks, knowledge about where to orient interventions is crucial...
  70. pmc Mucosal immunization with Vibrio cholerae outer membrane vesicles provides maternal protection mediated by antilipopolysaccharide antibodies that inhibit bacterial motility
    Anne L Bishop
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Infect Immun 78:4402-20. 2010
    Vibrio cholerae is the causative agent of cholera, a severe diarrheal disease that remains endemic in many parts of the world and can cause outbreaks wherever sanitation and clean water systems break down...
  71. pmc Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Biol 8:129. 2010
    ..Here I describe studies with a live oral cholera vaccine that include older children no longer deriving immune support from breast milk or maternal antibodies and ..
  72. ncbi The effect of rainfall on the incidence of cholera in Bangladesh
    Masahiro Hashizume
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Epidemiology 19:103-10. 2008
    The incidence of cholera in Bangladesh shows clear seasonality, suggesting that weather factors could play a role in its epidemiology. We estimated the effects of rainfall on the incidence of cholera in Dhaka, Bangladesh.
  73. pmc The high burden of cholera in children: comparison of incidence from endemic areas in Asia and Africa
    Jacqueline L Deen
    International Vaccine Institute, Seoul, Korea
    PLoS Negl Trop Dis 2:e173. 2008
    b>Cholera remains an important public health problem. Yet there are few reliable population-based estimates of laboratory-confirmed cholera incidence in endemic areas around the world.
  74. pmc FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae
    Marie Eve Val
    CNRS, Centre de Genetique Moleculaire, UPR 2167, Gif sur Yvette, France
    PLoS Genet 4:e1000201. 2008
    ..cholerae chromosomes. Chromosome II dimer resolution thus stands as a bona fide chromosomal process...
  75. pmc Characterization of VPI pathogenicity island and CTXphi prophage in environmental strains of Vibrio cholerae
    A K Mukhopadhyay
    Departments of Molecular Microbiology and Genetics, Washington University Medical School, St. Louis, Missouri 63110, USA
    J Bacteriol 183:4737-46. 2001
    ..DNA (RAPD) fingerprint types from Calcutta, India, that were unusual in containing toxin-coregulated pilus or cholera toxin genes but not O1 or O139 antigens of epidemic strains were studied by PCR and sequencing to gain insights ..
  76. pmc Protection from annual flooding is correlated with increased cholera prevalence in Bangladesh: a zero-inflated regression analysis
    Margaret Carrel
    Department of Geography, CB3220, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health 9:13. 2010
    ..of flood protection measures for a portion of an intensely monitored population in Matlab, Bangladesh, allows us to examine whether cholera outcomes respond positively or negatively to measures designed to control river flooding.
  77. pmc The sodium-driven flagellar motor controls exopolysaccharide expression in Vibrio cholerae
    Crystal M Lauriano
    Department of Biology, University of Texas San Antonio, 6900 N Loop 1604 West, San Antonio, TX 78249 0662, USA
    J Bacteriol 186:4864-74. 2004
    Vibrio cholerae causes the life-threatening diarrheal disease cholera. This organism persists in aquatic environments in areas of endemicity, and it is believed that the ability of the bacteria to form biofilms in the environment ..
  78. ncbi Regulation of virulence in Vibrio cholerae: the ToxR regulon
    Brandon M Childers
    Department of Microbiology and Immunology, San Antonio, TX 78229 3900, USA
    Future Microbiol 2:335-44. 2007
    Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera. This disease consists of enormous fluid loss through stools, which can be fatal...
  79. pmc Cholera in India: an analysis of reports, 1997-2006
    S Kanungo
    National Institute of Cholera and Enteric Diseases, P 33 CIT Road Scheme XM, Beliaghata, Kolkata, 700 010, India
    Bull World Health Organ 88:185-91. 2010
    To more accurately define the annual incidence of cholera in India, believed to be higher than reported to the World Health Organization (WHO).
  80. ncbi Spatial and temporal distribution of cholera in Ecuador between 1991 and 1996
    Emmanuelle Chevallier
    Département d épidémiologie et de santé publique, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Eur J Public Health 14:274-9. 2004
    The seventh pandemic of cholera affected South America in 1991 after a century of absence. Favoured by local conditions, the epidemic of cholera in Ecuador had a rapid impact...
  81. pmc Growth in a biofilm induces a hyperinfectious phenotype in Vibrio cholerae
    Rita Tamayo
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, 804 Manning Dr, CB 7290, Chapel Hill, NC 27599, USA
    Infect Immun 78:3560-9. 2010
    ..Furthermore, this work implies the existence of factors specifically induced during growth in a biofilm that augment infection by V. cholerae...
  82. pmc Activation of the Vibrio cholerae SOS response is not required for intestinal cholera toxin production or colonization
    Mariam Quinones
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Infect Immun 74:927-30. 2006
    b>Cholera toxin, one of the main virulence factors of Vibrio cholerae, is encoded in the genome of CTXphi, a V. cholerae-specific lysogenic filamentous bacteriophage...
  83. ncbi Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: a randomized, placebo-controlled trial
    Suman Kanungo
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Vaccine 27:6887-93. 2009
    Immune responses after one and two doses of the reformulated killed oral cholera vaccine were measured in a double-blind, randomized, placebo-controlled trial of 77 adults aged 18-40 years and 77 children aged 1-17 years residing in ..
  84. pmc Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR
    P J Cooper
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:1574-80. 2001
    ..of concurrent ascariasis on the cytokine response to a live oral vaccine, we measured cytokine responses to cholera toxin B subunit (CT-B) following vaccination with the live oral cholera vaccine CVD 103-HgR in Ascaris ..
  85. pmc Clinical outcomes in household contacts of patients with cholera in Bangladesh
    Ana A Weil
    International Centre for Diarrhoeal Disease Research Dhaka, Bangladesh
    Clin Infect Dis 49:1473-9. 2009
    ..cholerae infection and associated clinical symptoms in household contacts of patients with cholera and to identify risk factors for development of severe dehydration in this cohort.
  86. pmc Cholera and climate: a demonstrated relationship
    Guillaume Constantin de Magny
    Center of Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, Biomolecular Sciences Building 296, College Park, MD 20742, USA
    Trans Am Clin Climatol Assoc 120:119-28. 2009
    Vibrio cholerae, the causative agent of cholera, is naturally present in the environment and autochthonous to coastal and estuarine ecosystems. V...
  87. doi A large cholera outbreak due to a new cholera toxin variant of the Vibrio cholerae O1 El Tor biotype in Orissa, Eastern India
    P Kumar
    Biotechnology Division, Defence Research and Development Establishment DRDE, Jhansi Road, Gwalior 474002, India
    J Med Microbiol 58:234-8. 2009
    A total of 32 Vibrio cholerae isolates were collected during a recent large cholera outbreak in Eastern India. Biochemical and serological studies revealed that all of the isolates belonged to serogroup O1, biotype El Tor, serotype Ogawa...
  88. doi Influence of temperature and rainfall on the evolution of cholera epidemics in Lusaka, Zambia, 2003-2006: analysis of a time series
    Miguel Ángel Luque Fernández
    National Centre of Epidemiology CNE, Programa de Epidemiologia Aplicada de Campo, Instituto de Salud Carlos III, C Sinesio Delgado 6, Pabellón 12, 28029 Madrid, Spain
    Trans R Soc Trop Med Hyg 103:137-43. 2009
    In this study, we aimed to describe the evolution of three cholera epidemics that occurred in Lusaka, Zambia, between 2003 and 2006 and to analyse the association between the increase in number of cases and climatic factors...
  89. pmc Glycogen contributes to the environmental persistence and transmission of Vibrio cholerae
    Lori Bourassa
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Mol Microbiol 72:124-38. 2009
    ..Additionally, glycogen contributes to the pathogenesis of V. cholerae in a transmission model of cholera. A role for glycogen in the transmission of V...
  90. pmc Host-induced epidemic spread of the cholera bacterium
    D Scott Merrell
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nature 417:642-5. 2002
    ..Water-borne spread of the diarrhoeal disease cholera occurs rapidly in nature, whereas infection of human volunteers with bacteria grown in vitro is difficult in the ..
  91. pmc Cholera in Mozambique, variant of Vibrio cholerae
    M Ansaruzzaman
    Emerg Infect Dis 10:2057-9. 2004
  92. pmc Cholera outbreak in southern Tanzania: risk factors and patterns of transmission
    C J Acosta
    Ifakara Health Research and Development Centre, Ifakara, Tanzania
    Emerg Infect Dis 7:583-7. 2001
    To identify risk factors and describe the pattern of spread of the 1997 cholera epidemic in a rural area (Ifakara) in southern Tanzania, we conducted a prospective hospital-based, matched case- control study, with analysis based on the ..
  93. pmc Viable but nonculturable Vibrio cholerae O1 in biofilms in the aquatic environment and their role in cholera transmission
    Munirul Alam
    International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Proc Natl Acad Sci U S A 104:17801-6. 2007
    ..In contrast to biofilms produced in Mathbaria pond water, V. cholerae O1 in biofilms present in cholera stools and incubated under identical conditions as the Mathbaria pond water biofilms could not be cultured after ..
  94. ncbi Oral cholera vaccines: use in clinical practice
    David R Hill
    National Travel Health Network and Centre, London, UK
    Lancet Infect Dis 6:361-73. 2006
    b>Cholera continues to occur globally, particularly in sub-Saharan Africa and Asia. Oral cholera vaccines have been developed and have now been used for several years, primarily in traveller populations...
  95. pmc Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae
    David M Raskin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:4636-41. 2007
    ..We suggest that the essential function of CgtA is as a repressor of the stringent response that acts by regulating SpoT activity to maintain low ppGpp levels when bacteria are growing in a nutrient-rich environment...
  96. pmc Reduction of cholera in Bangladeshi villages by simple filtration
    Rita R Colwell
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 100:1051-5. 2003
    Based on results of ecological studies demonstrating that Vibrio cholerae, the etiological agent of epidemic cholera, is commensal to zooplankton, notably copepods, a simple filtration procedure was developed whereby zooplankton, most ..
  97. ncbi Geographical distribution and risk factors associated with enteric diseases in Vietnam
    Louise A Kelly-Hope
    Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 76:706-12. 2007
    In Vietnam, shigellosis, typhoid fever, and cholera are important enteric diseases...
  98. pmc Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment
    Shah M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 103:6350-5. 2006
    ..Although the epidemic diarrheal disease cholera is known to be transmitted by water contaminated with pathogenic Vibrio cholerae, routine isolation of pathogenic ..
  99. ncbi Safety of rapid intravenous rehydration and comparative efficacy of 3 oral rehydration solutions in the treatment of severely malnourished children with dehydrating cholera
    Nur H Alam
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    J Pediatr Gastroenterol Nutr 48:318-27. 2009
    ..Assess the safety of rapid intravenous rehydration of severely malnourished children and compare the efficacy of 3 formulations of oral rehydration salts solutions...
  100. pmc Transmission of Vibrio cholerae is antagonized by lytic phage and entry into the aquatic environment
    Eric J Nelson
    Howard Hughes Medical Institute, USA
    PLoS Pathog 4:e1000187. 2008
    b>Cholera outbreaks are proposed to propagate in explosive cycles powered by hyperinfectious Vibrio cholerae and quenched by lytic vibriophage...
  101. pmc Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants
    M Shamim Hasan Zahid
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    Infect Immun 76:5266-73. 2008
    Seasonal epidemics of cholera in Bangladesh are self-limited in nature, presumably due to phage predation of the causative Vibrio cholerae during the late stage of an epidemic, when cholera patients excrete large quantities of phage in ..

Research Grants95

  1. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall K Holmes; Fiscal Year: 2010
    About 4 billion cases of diarrhea occur annually and cause 4% of all deaths worldwide. Cholera caused by Vibrio cholerae and watery diarrhea caused by enterotoxigenic Escherichia coli (ETEC) cause substantial morbidity and mortality ..
  2. EPIDEMIOLOGY & ECOLOGY OF VIBRIO CHOLERAE IN BANGLADESH
    Richard Sack; Fiscal Year: 2000
    DESCRIPTION: (Adapted from Applicant's Abstract). Cholera, the most severe of all diarrheal diseases, caused by Vibrio cholerae 01 (and most recently also by serogroup 0139) is one of the few pandemic infections of man...
  3. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2007
    About 4 billion cases of diarrhea occur annually and cause 4% of all deaths worldwide. Cholera caused by Vibrio cholerae and watery diarrhea caused by enterotoxigenic Escherichia coli (ETEC) cause substantial morbidity and mortality ..
  4. Study of transmissible forms of Vibrio cholerae
    Andrew Camilli; Fiscal Year: 2007
    ..with plankton in brackish, temperate waters the world over, is the causative agent of endemic and epidemic cholera. Hallmarks of the disease include prodigious watery diarrhea resulting from the action of secreted cholera toxin (..
  5. Lactobacilli surface antibody expression for in vivo protection against cholera
    Paul Wentworth; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cholera, sometimes known as Asian or epidemic cholera, is an infectious gastroenteritis caused by enterotoxin-producing strains of the bacterium Vibrio cholerae. The NIAID has characterized V...
  6. Regulation of the Vibrio cholerae intestinal exit plan
    ANISIA SILVA BENITEZ; Fiscal Year: 2009
    b>Cholera is an acute water-borne diarrheal disease caused by Vibrio cholerae of serogroups O1 and O139. The bacterium is transmitted person-to-person by the fecal oral route...
  7. Regulation of the Vibrio cholerae intestinal exit plan
    ANISIA J SILVA BENITEZ; Fiscal Year: 2010
    b>Cholera is an acute water-borne diarrheal disease caused by Vibrio cholerae of serogroups O1 and O139. The bacterium is transmitted person-to-person by the fecal oral route...
  8. Effects of Climate Change on Cholera Dynamics and Prediction
    Shafiqul Islam; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cholera has reemerged as a global killer with the world witnessing an unprecedented rise in cholera infection and transmission over the past two decades...
  9. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2009
    About 4 billion cases of diarrhea occur annually and cause 4% of all deaths worldwide. Cholera caused by Vibrio cholerae and watery diarrhea caused by enterotoxigenic Escherichia coli (ETEC) cause substantial morbidity and mortality ..
  10. MAST CELL MEMBRANE GLYCOLIPID EXPRESSION AND FUNCTION
    Michael Raizman; Fiscal Year: 1990
    ..is designed to learn more about mast cell differentiation through studies of the expression and function of a cholera toxin-binding glycosphingolipid, ganglisoside GM1, on mouse mast cells at different stages of development...
  11. ESCHERICHIA COLI LT-RELATED ENTEROTOXINS
    RICHARD FINKELSTEIN; Fiscal Year: 1990
    ..diarrheagenic enterotoxins which are structurally, functionally and immunologically related to the prototype, the cholera entertoxin (a.k.a. choleragen, cholera toxin, or CT), which was first isolated to homogeneity in 1969...
  12. ESCHERICHIA COLI LT-RELATED ENTEROTOXINS
    RICHARD FINKELSTEIN; Fiscal Year: 1991
    ..diarrheagenic enterotoxins which are structurally, functionally and immunologically related to the prototype, the cholera entertoxin (a.k.a. choleragen, cholera toxin, or CT), which was first isolated to homogeneity in 1969...
  13. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2000
    DESCRIPTION (Adapted from the applicant's abstract): Cholera, and related diarrheal diseases, are the #3 cause of all deaths worldwide...
  14. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Cholera, and related diarrheal diseases, are the #3 cause of all deaths worldwide...
  15. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Cholera, and related diarrheal diseases, are the #3 cause of all deaths worldwide...
  16. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 1999
    DESCRIPTION (Adapted from the applicant's abstract): Cholera, and related diarrheal diseases, are the #3 cause of all deaths worldwide...
  17. EPIDEMIOLOGY & ECOLOGY OF VIBRIO CHOLERAE IN BANGLADESH
    Richard Sack; Fiscal Year: 1999
    DESCRIPTION: (Adapted from Applicant's Abstract). Cholera, the most severe of all diarrheal diseases, caused by Vibrio cholerae 01 (and most recently also by serogroup 0139) is one of the few pandemic infections of man...
  18. PERTUSSIS, DIPHTHERIA, CHOLERA TOXINS--INHIBITOR DESIGN
    Vern Schramm; Fiscal Year: 1993
    Pertussis, diphtheria and cholera infections affect an estimated 100 million people each year with an estimated 1 million fatalities. Recently, local epidemics have occurred...
  19. Epidemiology and Ecology of Vibrio cholerae in Bangladesh
    Richard Bradley Sack; Fiscal Year: 2010
    DESCRIPTION (provided by investigator): Cholera, caused by Vibrio cholerae serogroups O1 and O139, is the most severe of diarrheal diseases and continues to cause significant morbidity and mortality throughout the developing world...
  20. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper Boyaka; Fiscal Year: 2009
    ..We used cholera toxin and developed novel derivatives lacking ADP ribosyl transferase activity to circumvent the reactogenicity ..
  21. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2011
    ..We used cholera toxin and developed novel derivatives lacking ADP ribosyl transferase activity to circumvent the reactogenicity ..
  22. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2010
    ..We used cholera toxin and developed novel derivatives lacking ADP ribosyl transferase activity to circumvent the reactogenicity ..
  23. TRAINING GRANT IN MUCOSAL IMMUNOLOGY AND EPIDEMIOLOGY
    Stephen Calderwood; Fiscal Year: 2006
    ..Award, we proposed to investigate those components of the mucosal immune response that are protective against cholera in an area of the world endemic for V...
  24. IMMUNE PROPHYLAXIS AGAINST AMEBIASIS
    JONATHAN RAVDIN; Fiscal Year: 2001
    ..Subcutaneous vaccination with LC3 provides immunity in the gerbil model of ALA, oral immunization with LC3 and cholera toxin induces are adherence/inhibitory anti-lectin mucosal secretory IgA response in BALB/c mice...
  25. IMMUNE PROPHYLAXIS AGAINST AMEBIASIS
    JONATHAN RAVDIN; Fiscal Year: 2002
    ..Subcutaneous vaccination with LC3 provides immunity in the gerbil model of ALA, oral immunization with LC3 and cholera toxin induces are adherence/inhibitory anti-lectin mucosal secretory IgA response in BALB/c mice...
  26. IMMUNE PROPHYLAXIS AGAINST AMEBIASIS
    JONATHAN RAVDIN; Fiscal Year: 2000
    ..Subcutaneous vaccination with LC3 provides immunity in the gerbil model of ALA, oral immunization with LC3 and cholera toxin induces are adherence/inhibitory anti-lectin mucosal secretory IgA response in BALB/c mice...
  27. Pathogenic mechanisms of non-01/non-0139 V. cholerae
    Michelle Dziejman; Fiscal Year: 2009
    Vibrio cholerae is the causative agent of the severe diarrheal disease, cholera, that is endemic in much of Asia, Africa, and South America...
  28. Study of transmissible forms of Vibrio cholerae
    Andrew Camilli; Fiscal Year: 2006
    ..with plankton in brackish, temperate waters the world over, is the causative agent of endemic and epidemic cholera. Hallmarks of the disease include prodigious watery diarrhea resulting from the action of secreted cholera toxin (..
  29. Study of transmissible forms of Vibrio cholerae
    Andrew Camilli; Fiscal Year: 2005
    ..with plankton in brackish, temperate waters the world over, is the causative agent of endemic and epidemic cholera. Hallmarks of the disease include prodigious watery diarrhea resulting from the action of secreted cholera toxin (..
  30. Study of transmissible forms of Vibrio cholerae
    Andrew Camilli; Fiscal Year: 2004
    ..with plankton in brackish, temperate waters the world over, is the causative agent of endemic and epidemic cholera. Hallmarks of the disease include prodigious watery diarrhea resulting from the action of secreted cholera toxin (..
  31. Study of transmissible forms of Vibrio cholerae
    Andrew Camilli; Fiscal Year: 2003
    ..with plankton in brackish, temperate waters the world over, is the causative agent of endemic and epidemic cholera. Hallmarks of the disease include prodigious watery diarrhea resulting from the action of secreted cholera toxin (..
  32. A Screen for Small Molecule Compounds that Inhibit Bacterial Toxins
    David Haslam; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Shiga toxin (Stx), cholera toxin (Ctx) and ricin are important mediators of human disease and are potential agents of biowarfare...
  33. A Novel Mechanism for Toxin Export from the Endoplasmic Reticulum to the Cytosol
    KENNETH R TETER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cholera toxin (CT), produced by Vibrio cholerae, induces the life-threatening diarrhea of cholera...
  34. VIBRIO CHOLERAE TCP AND LPS SUBUNIT VACCINE, EPITOPES AN
    William Wade; Fiscal Year: 2002
    b>Cholera is an acute diarrheal disease caused by the gram-negative bacterium, Vibrio cholerae...
  35. VIBRIO CHOLERAE TCP AND LPS SUBUNIT VACCINE, EPITOPES AN
    William Wade; Fiscal Year: 2001
    b>Cholera is an acute diarrheal disease caused by the gram-negative bacterium, Vibrio cholerae...
  36. VIBRIO CHOLERAE TCP AND LPS SUBUNIT VACCINE, EPITOPES AN
    William Wade; Fiscal Year: 2000
    b>Cholera is an acute diarrheal disease caused by the gram-negative bacterium, Vibrio cholerae...
  37. VIBRIO CHOLERAE TCP AND LPS SUBUNIT VACCINE, EPITOPES AN
    William Wade; Fiscal Year: 2003
    b>Cholera is an acute diarrheal disease caused by the gram-negative bacterium, Vibrio cholerae...
  38. SIGNAL TRANSDUCTION IN T CELLS
    CONSTANTINE TSOUKAS; Fiscal Year: 1990
    ..in membranes of human T cells by using 32p-NAD and by taking advantage of the ability of bacterial toxins (cholera and pertussis toxin) to specifically ADP- ribosylate the Alpha subunits in vitro using the radioactive NAD as a ..
  39. NEW MECHANISMS FOR REGULATING VIRULENCE GENE EXPRESSION
    Karen Skorupski; Fiscal Year: 2000
    ..For the human pathogen Vibrio cholerae, the coordinate expression of cholera toxin (CT), toxin-coregulated pilus (TCP), and a number of other virulence factors is strongly influenced by ..
  40. NEW MECHANISMS FOR REGULATING VIRULENCE GENE EXPRESSION
    Karen Skorupski; Fiscal Year: 2001
    ..For the human pathogen Vibrio cholerae, the coordinate expression of cholera toxin (CT), toxin-coregulated pilus (TCP), and a number of other virulence factors is strongly influenced by ..
  41. NEW MECHANISMS FOR REGULATING VIRULENCE GENE EXPRESSION
    Karen Skorupski; Fiscal Year: 1999
    ..For the human pathogen Vibrio cholerae, the coordinate expression of cholera toxin (CT), toxin-coregulated pilus (TCP), and a number of other virulence factors is strongly influenced by ..
  42. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2006
    ..billion cases of diarrhea cause 4 million deaths annually in children under 5 years old, and 5-7 million cases of cholera cause about 100,000 deaths. Cholera toxin (CT) from Vibrio cholerae causes the massive watery diarrhea of cholera...
  43. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2005
    ..billion cases of diarrhea cause 4 million deaths annually in children under 5 years old, and 5-7 million cases of cholera cause about100,000 deaths. Cholera toxin (CT) from Vibrio cholerae causes the massive watery diarrhea of cholera...
  44. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2003
    ..billion cases of diarrhea cause 4 million deaths annually in children under 5 years old, and 5-7 million cases of cholera cause about100,000 deaths. Cholera toxin (CT) from Vibrio cholerae causes the massive watery diarrhea of cholera...
  45. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2002
    ..billion cases of diarrhea cause 4 million deaths annually in children under 5 years old, and 5-7 million cases of cholera cause about100,000 deaths. Cholera toxin (CT) from Vibrio cholerae causes the massive watery diarrhea of cholera...
  46. GENETIC ANALYSIS OF CHOLERA TOXIN STRUCTURE AND FUNCTION
    Randall Holmes; Fiscal Year: 2004
    ..billion cases of diarrhea cause 4 million deaths annually in children under 5 years old, and 5-7 million cases of cholera cause about100,000 deaths. Cholera toxin (CT) from Vibrio cholerae causes the massive watery diarrhea of cholera...
  47. MOLECULAR MODE OF ACTION OF BACTERIAL ENTEROTOXINS
    JOHNNY PETERSON; Fiscal Year: 1999
    ..The applicant's overall research objective is to define essential components in the mechanism of action of cholera toxin (CT) on water and electrolyte secretion in the small intestine...
  48. Retrotranslocation of cholera toxin AI-chain from ER ot cytosol and cell response
    JIN CHO; Fiscal Year: 2009
    ..The overarching goal of this application is to elucidate the molecular basis for retro-translocation of the cholera toxin (CT) A1-chain from within the lumen of the endoplasmic reticulum (ER) of host cells to the cytosol...
  49. Protecutive immunity to human cholera in Bangladesh
    Edward T Ryan; Fiscal Year: 2010
    ..Unfortunately, protective immunity following cholera is not currently understood, and available cholera vaccines either fail to produce full protective efficacy or ..
  50. Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.
    Alexandra Purdy; Fiscal Year: 2009
    b>Cholera, which is caused by ingestion of the Gram-negative pathogen Vibrio cholerae, persists worldwide and affects many thousands of people each year, most of whom do not have access to clean water and sanitary conditions...
  51. Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.
    ALEXANDRA ELIZABETH PURDY; Fiscal Year: 2010
    b>Cholera, which is caused by ingestion of the Gram-negative pathogen Vibrio cholerae, persists worldwide and affects many thousands of people each year, most of whom do not have access to clean water and sanitary conditions...
  52. Interaction between Vibrio cholerae and Dictylostelium discoideum
    SHELLEY PAYNE; Fiscal Year: 2009
    ..Vibrio cholerae, in particular, has a long history of causing epidemic and pandemic cholera. Cholera results from colonization of the small intestine by V...
  53. ADP RIBOSYLATION OF A POTENT INDUCER OF PROLIFERATION
    Mark Francis; Fiscal Year: 2001
    ..Based on his previous work, the applicant hypothesizes that cholera toxin ADP-ribosylates a non-Gs protein that regulates B cell activation...
  54. ADP RIBOSYLATION OF A POTENT INDUCER OF PROLIFERATION
    Mark Francis; Fiscal Year: 1999
    ..Based on his previous work, the applicant hypothesizes that cholera toxin ADP-ribosylates a non-Gs protein that regulates B cell activation...
  55. ADP RIBOSYLATION OF A POTENT INDUCER OF PROLIFERATION
    Mark Francis; Fiscal Year: 2002
    ..Based on his previous work, the applicant hypothesizes that cholera toxin ADP-ribosylates a non-Gs protein that regulates B cell activation...
  56. ADP RIBOSYLATION OF A POTENT INDUCER OF PROLIFERATION
    Mark Francis; Fiscal Year: 2000
    ..Based on his previous work, the applicant hypothesizes that cholera toxin ADP-ribosylates a non-Gs protein that regulates B cell activation...
  57. DC-T Cell Interactions in Pulmonary Immune Responses
    Anuradha Ray; Fiscal Year: 2009
    ..Our studies show that the allergen house dust mite and the Th2-skewing mucosal adjuvant cholera toxin (CT) induce expression of c-kit and its ligand, stem cell factor, on DCs resulting in high level of ..
  58. Genetic and Biochemical Study of V. cholerae RTX Toxin
    KARLA SATCHELL; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The life-threatening diarrheal disease cholera is caused by toxigenic strains of the Gram-negative organism Vibrio cholerae...
  59. REAL TIME ANALYSIS OF TOXIN RECEPTOR INTERACTIONS FOR BIOSENSOR APPLICATIONS
    John Nolan; Fiscal Year: 2000
    ..While cholera toxin was chosen for initial studies because of its experimental accessibility, ganglioside binding is a common ..
  60. REAL TIME ANALYSIS OF TOXIN RECEPTOR INTERACTIONS FOR BIOSENSOR APPLICATIONS
    John Nolan; Fiscal Year: 2001
    ..While cholera toxin was chosen for initial studies because of its experimental accessibility, ganglioside binding is a common ..
  61. REAL TIME ANALYSIS OF TOXIN RECEPTOR INTERACTIONS FOR BIOSENSOR APPLICATIONS
    John Nolan; Fiscal Year: 1999
    ..While cholera toxin was chosen for initial studies because of its experimental accessibility, ganglioside binding is a common ..
  62. Genetic and Biochemical Study of V. cholerae RTX Toxin
    Karla J F Satchell; Fiscal Year: 2010
    Abstract The life-threatening diarrheal disease cholera is caused by toxigenic strains of the Gram-negative organism Vibrio cholerae. In addition to the well-characterized ADP-ribosylating cholera toxin (CT), V...
  63. Genetic and Biochemical Study of V. cholerae RTX Toxin
    Karla J F Satchell; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The life-threatening diarrheal disease cholera is caused by toxigenic strains of the Gram-negative organism Vibrio cholerae...
  64. GLYCOSPHINGOLIPIDS AND GM1-CHOLERA TOXIN INTERACTIONS
    G Shipley; Fiscal Year: 1999
    ..membrane lipids, and (3) the role of GSL as receptors for bacterial toxins, with emphasis on the ganglioside GM1-cholera toxin system...
  65. GLYCOSPHINGOLIPIDS AND GM1-CHOLERA TOXIN INTERACTIONS
    G Shipley; Fiscal Year: 2000
    ..membrane lipids, and (3) the role of GSL as receptors for bacterial toxins, with emphasis on the ganglioside GM1-cholera toxin system...
  66. ACCESSORY CHOLERA ENTEROTOXIN, ACE, MECHANISM OF ACTION
    Michele Trucksis; Fiscal Year: 2006
    ..by applicant): Colonization of the small intestine by Vibrio cholerae causes the potentially lethal disease cholera due to massive salt and water secretion...
  67. POPULATION BIOLOGY OF SURFACE POLYSACCHARIDES IN CHOLERA
    John Morris; Fiscal Year: 2002
    b>Cholera is an ancient disease in the midst of a modern resurgence, with cases reported to WHO by 65 member nations in Asia, Africa, the Americas, and Europe in 1997. With the appearance of V...
  68. POPULATION BIOLOGY OF SURFACE POLYSACCHARIDES IN CHOLERA
    John Morris; Fiscal Year: 2002
    b>Cholera is an ancient disease in the midst of a modern resurgence, with cases reported to WHO by 65 member nations in Asia, Africa, the Americas, and Europe in 1997. With the appearance of V...
  69. POPULATION BIOLOGY OF SURFACE POLYSACCHARIDES IN CHOLERA
    John Morris; Fiscal Year: 2002
    b>Cholera is an ancient disease in the midst of a modern resurgence, with cases reported to WHO by 65 member nations in Asia, Africa, the Americas, and Europe in 1997. With the appearance of V...
  70. POPULATION BIOLOGY OF SURFACE POLYSACCHARIDES IN CHOLERA
    John Morris; Fiscal Year: 2004
    b>Cholera is an ancient disease in the midst of a modern resurgence, with cases reported to WHO by 65 member nations in Asia, Africa, the Americas, and Europe in 1997. With the appearance of V...
  71. ACCESSORY CHOLERA ENTEROTOXIN, ACE, MECHANISM OF ACTION
    Michele Trucksis; Fiscal Year: 2003
    Colonization of the small intestine by Vibrio cholerae causes the potentially lethal disease cholera due to massive salt and water secretion...
  72. POPULATION BIOLOGY OF SURFACE POLYSACCHARIDES IN CHOLERA
    John Morris; Fiscal Year: 2003
    b>Cholera is an ancient disease in the midst of a modern resurgence, with cases reported to WHO by 65 member nations in Asia, Africa, the Americas, and Europe in 1997. With the appearance of V...
  73. ACCESSORY CHOLERA ENTEROTOXIN, ACE, MECHANISM OF ACTION
    Michele Trucksis; Fiscal Year: 2005
    Colonization of the small intestine by Vibrio cholerae causes the potentially lethal disease cholera due to massive salt and water secretion...
  74. CHOLERA--PATHOGENESIS AND IMMUNOLOGY
    RICHARD FINKELSTEIN; Fiscal Year: 1992
    The goals of this research are to contribute to the understanding of the pathogenesis of cholera, an epidemic diarrheal disease caused by Vibrio cholerae 01, at both the organismal and the molecular levels, with the expectation that this ..
  75. Functional characterization of Rho inactivation by Vibro cholerae RTX toxin
    BRETT L GEISSLER; Fiscal Year: 2010
    Vibrio cholerae is responsible for causing the life-threatening diarrheal disease cholera. The World Health Organization confirmed 236,896 cases and 6,311 deaths from cholera in 2006. V...
  76. Functional characterization of Rho inactivation by Vibro cholerae RTX toxin
    Brett Geissler; Fiscal Year: 2009
    Vibrio cholerae is responsible for causing the life-threatening diarrheal disease cholera. The World Health Organization confirmed 236,896 cases and 6,311 deaths from cholera in 2006. V...
  77. Accessory toxin-mediated evasion of innate immunity during V. cholerae infection
    KARLA SATCHELL; Fiscal Year: 2009
    Vibrio cholerae O1 is the causative agent of pandemic cholera, a severe diarrheal disease still prevalent worldwide...
  78. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David Saslowsky; Fiscal Year: 2007
    ..b>Cholera toxin (CT), the causative agent of Asiatic cholera, typifies the structure and function of the AB5-subunit toxins ..
  79. Accessory toxin-mediated evasion of innate immunity during V. cholerae infection
    Karla J F Satchell; Fiscal Year: 2010
    Vibrio cholerae O1 is the causative agent of pandemic cholera, a severe diarrheal disease still prevalent worldwide...
  80. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David Saslowsky; Fiscal Year: 2006
    ..b>Cholera toxin (CT), the causative agent of Asiatic cholera, typifies the structure and function of the AB5-subunit toxins ..
  81. Retro-translocation of cholera toxin in intestinal cells: from ER to cytosol
    NAOMI WERNICK; Fiscal Year: 2007
    The goal of this application is to elucidate the molecular basis for retro-translocation of the cholera toxin (CT) A1-chain from within the lumen of the endoplasmic reticulum (ER) to the cytosol...
  82. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David Saslowsky; Fiscal Year: 2009
    ..b>Cholera toxin (CT), the causative agent of Asiatic cholera, typifies the structure and function of the AB5-subunit toxins ..
  83. Retro-translocation of cholera toxin in intestinal cells: from ER to cytosol
    NAOMI WERNICK; Fiscal Year: 2009
    ..by applicant): The goal of this application is to elucidate the molecular basis for retro-translocation of the cholera toxin (CT) A1-chain from within the lumen of the endoplasmic reticulum (ER) to the cytosol...
  84. Accessory toxin-mediated evasion of innate immunity during V. cholerae infection
    Karla J F Satchell; Fiscal Year: 2010
    Vibrio cholerae O1 is the causative agent of pandemic cholera, a severe diarrheal disease still prevalent worldwide...
  85. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David E Saslowsky; Fiscal Year: 2010
    ..b>Cholera toxin (CT), the causative agent of Asiatic cholera, typifies the structure and function of the AB5-subunit toxins ..
  86. MOLECULAR BIOLOGY AND VIRULENCE OF CTX PHAGE
    Matthew Waldor; Fiscal Year: 2003
    CTXphi is a filamentous bacteriophage that encodes cholera toxin. This is the principal virulence factor of Vibrio cholerae, the Gram-negative bacterium that causes the severe diarrheal disease cholera...
  87. Retrotranslocation of cholera toxin AI-chain from ER ot cytosol and cell response
    Jin Ah Cho; Fiscal Year: 2010
    ..The overarching goal of this application is to elucidate the molecular basis for retro-translocation of the cholera toxin (CT) A1-chain from within the lumen of the endoplasmic reticulum (ER) of host cells to the cytosol...
  88. IMMUNE RESPONSES TO V. CHOLERAE INFECTION IN BANGLADESH
    Stephen Calderwood; Fiscal Year: 2000
    ..There are an estimated 5-7 million cases worldwide of cholera, with more than 100,000 deaths...
  89. MOLECULAR BIOLOGY AND VIRULENCE OF CTX PHAGE
    Matthew Waldor; Fiscal Year: 2005
    CTXphi is a filamentous bacteriophage that encodes cholera toxin. This is the principal virulence factor of Vibrio cholerae, the Gram-negative bacterium that causes the severe diarrheal disease cholera...