cholera

Summary

Summary: An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.

Top Publications

  1. pmc Evidence for several waves of global transmission in the seventh cholera pandemic
    Ankur Mutreja
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 477:462-5. 2011
  2. pmc Genomic diversity of 2010 Haitian cholera outbreak strains
    Nur A Hasan
    Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 109:E2010-7. 2012
  3. pmc The origin of the Haitian cholera outbreak strain
    Chen Shan Chin
    Pacific Biosciences, Menlo Park, CA, USA
    N Engl J Med 364:33-42. 2011
  4. pmc Cholera
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Lancet 379:2466-76. 2012
  5. pmc The global burden of cholera
    Mohammad Ali
    International Vaccine Institute, SNU Research Park, Seoul, Republic of Korea
    Bull World Health Organ 90:209-218A. 2012
  6. ncbi Cholera
    David A Sack
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Dhaka, Bangladesh
    Lancet 363:223-33. 2004
  7. pmc Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae
    S M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Microbiol Mol Biol Rev 62:1301-14. 1998
  8. pmc Quorum-sensing regulators control virulence gene expression in Vibrio cholerae
    Jun Zhu
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3129-34. 2002
  9. pmc Population genetics of Vibrio cholerae from Nepal in 2010: evidence on the origin of the Haitian outbreak
    Rene S Hendriksen
    National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark
    MBio 2:e00157-11. 2011
  10. ncbi Cholera surveillance during the Haiti epidemic--the first 2 years
    Ezra J Barzilay
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS A 05, Atlanta, GA 30329, USA
    N Engl J Med 368:599-609. 2013

Detail Information

Publications343 found, 100 shown here

  1. pmc Evidence for several waves of global transmission in the seventh cholera pandemic
    Ankur Mutreja
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 477:462-5. 2011
    ..a globally important pathogen that is endemic in many areas of the world and causes 3-5 million reported cases of cholera every year...
  2. pmc Genomic diversity of 2010 Haitian cholera outbreak strains
    Nur A Hasan
    Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 109:E2010-7. 2012
    The millions of deaths from cholera during the past 200 y, coupled with the morbidity and mortality of cholera in Haiti since October 2010, are grim reminders that Vibrio cholerae, the etiologic agent of cholera, remains a scourge...
  3. pmc The origin of the Haitian cholera outbreak strain
    Chen Shan Chin
    Pacific Biosciences, Menlo Park, CA, USA
    N Engl J Med 364:33-42. 2011
    Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera in Haiti.
  4. pmc Cholera
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Lancet 379:2466-76. 2012
    b>Cholera is an acute, secretory diarrhoea caused by infection with Vibrio cholerae of the O1 or O139 serogroup. It is endemic in more than 50 countries and also causes large epidemics...
  5. pmc The global burden of cholera
    Mohammad Ali
    International Vaccine Institute, SNU Research Park, Seoul, Republic of Korea
    Bull World Health Organ 90:209-218A. 2012
    To estimate the global burden of cholera using population-based incidence data and reports.
  6. ncbi Cholera
    David A Sack
    International Centre for Diarrhoeal Disease Research, Bangladesh, Centre for Health and Population Research, Dhaka, Bangladesh
    Lancet 363:223-33. 2004
    ..Without adequate and appropriate rehydration therapy, severe cholera kills about half of affected individuals...
  7. pmc Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae
    S M Faruque
    Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    Microbiol Mol Biol Rev 62:1301-14. 1998
    b>Cholera caused by toxigenic Vibrio cholerae is a major public health problem confronting developing countries, where outbreaks occur in a regular seasonal pattern and are particularly associated with poverty and poor sanitation...
  8. pmc Quorum-sensing regulators control virulence gene expression in Vibrio cholerae
    Jun Zhu
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3129-34. 2002
    The production of virulence factors including cholera toxin and the toxin-coregulated pilus in the human pathogen Vibrio cholerae is strongly influenced by environmental conditions...
  9. pmc Population genetics of Vibrio cholerae from Nepal in 2010: evidence on the origin of the Haitian outbreak
    Rene S Hendriksen
    National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark
    MBio 2:e00157-11. 2011
    b>Cholera continues to be an important cause of human infections, and outbreaks are often observed after natural disasters, such as the one following the 2010 earthquake in Haiti...
  10. ncbi Cholera surveillance during the Haiti epidemic--the first 2 years
    Ezra J Barzilay
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS A 05, Atlanta, GA 30329, USA
    N Engl J Med 368:599-609. 2013
    In October 2010, nearly 10 months after a devastating earthquake, Haiti was stricken by epidemic cholera. Within days after detection, the Ministry of Public Health and Population established a National Cholera Surveillance System (NCSS).
  11. ncbi Evolution of new variants of Vibrio cholerae O1
    Ashrafus Safa
    Department of Biology and Chemistry and MERIT, City University of Hong Kong, 83, Tat Chee Avenue, Kowloon Tong, Kowloon, Hong Kong SAR
    Trends Microbiol 18:46-54. 2010
    Vibrio cholerae typically contains a prophage that carries the genes encoding the cholera toxin, which is responsible for the major clinical symptoms of the disease. In recent years, new pathogenic variants of V...
  12. pmc Effects of global climate on infectious disease: the cholera model
    Erin K Lipp
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Clin Microbiol Rev 15:757-70. 2002
    ..b>Cholera, caused by Vibrio cholerae, lends itself to analyses of the role of climate in infectious disease, coupled to ..
  13. pmc Reassessment of the 2010-2011 Haiti cholera outbreak and rainfall-driven multiseason projections
    Andrea Rinaldo
    Laboratory of Ecohydrology, School of Architecture, Civil and Environmental Engineering, Global Health Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 109:6602-7. 2012
    ..We study the ex post reliability of predictions of the 2010-2011 Haiti cholera outbreak from four independent modeling studies that appeared almost simultaneously during the unfolding epidemic...
  14. pmc Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS Negl Trop Dis 2:e221. 2008
    ..Despite recent progress in understanding the molecular basis of Vibrio cholerae pathogenesis, there is relatively little knowledge of the factors that determine the variability in human susceptibility to V. cholerae infection...
  15. pmc Social and news media enable estimation of epidemiological patterns early in the 2010 Haitian cholera outbreak
    Rumi Chunara
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Am J Trop Med Hyg 86:39-45. 2012
    ..We assessed correlation of volume of cholera-related HealthMap news media reports, Twitter postings, and government cholera cases reported in the first 100 ..
  16. ncbi Cholera dynamics and El Niño-Southern Oscillation
    M Pascual
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Suite 236, Columbus Center, Baltimore, MD 21202, USA
    Science 289:1766-9. 2000
    Analysis of a monthly 18-year cholera time series from Bangladesh shows that the temporal variability of cholera exhibits an interannual component at the dominant frequency of El Niño-Southern Oscillation (ENSO)...
  17. pmc Vaccination strategies for epidemic cholera in Haiti with implications for the developing world
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 108:7081-5. 2011
    In October 2010, a virulent South Asian strain of El Tor cholera began to spread in Haiti. Interventions have included treatment of cases and improved sanitation...
  18. ncbi Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Lancet 374:1694-702. 2009
    Oral cholera vaccines consisting of killed whole cells have been available for many years, but they have not been used extensively in populations with endemic disease...
  19. pmc Comparative genomics of Vibrio cholerae from Haiti, Asia, and Africa
    Aleisha R Reimer
    Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Emerg Infect Dis 17:2113-21. 2011
    b>Cholera was absent from the island of Hispaniola at least a century before an outbreak that began in Haiti in the fall of 2010...
  20. ncbi El Tor cholera with severe disease: a new threat to Asia and beyond
    A K Siddique
    Public Health Sciences Division PHSD, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Epidemiol Infect 138:347-52. 2010
    During epidemics of cholera in two rural sites (Bakerganj and Mathbaria), a much higher proportion of patients came for treatment with severe dehydration than was seen in previous years. V...
  21. pmc Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    J Clin Microbiol 44:4211-3. 2006
    We determined the types of cholera toxin (CT) produced by a collection of 185 Vibrio cholerae O1 strains isolated in Bangladesh over the past 45 years. All of the El Tor strains of V...
  22. pmc Characterization of Vibrio cholerae O1 El Tor biotype variant clinical isolates from Bangladesh and Haiti, including a molecular genetic analysis of virulence genes
    Mike S Son
    Department of Microbiology and Immunology, Dartmouth Medical School, Vail Building HB7550, Hanover, NH 03755, USA
    J Clin Microbiol 49:3739-49. 2011
    Vibrio cholerae serogroup O1, the causative agent of the diarrheal disease cholera, is divided into two biotypes: classical and El Tor...
  23. ncbi Safety and immunogenicity study of a killed bivalent (O1 and O139) whole-cell oral cholera vaccine Shanchol, in Bangladeshi adults and children as young as 1 year of age
    Amit Saha
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Vaccine 29:8285-92. 2011
    Safety and immunogenicity study of an oral, killed, bivalent whole-cell, cholera vaccine, Shanchol was carried out in Bangladeshi participants. This study was conducted prior to initiating a feasibility study in Bangladesh.
  24. pmc Efficacy of a low-cost, inactivated whole-cell oral cholera vaccine: results from 3 years of follow-up of a randomized, controlled trial
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    PLoS Negl Trop Dis 5:e1289. 2011
    Killed oral cholera vaccines (OCVs) have been licensed for use in developing countries, but protection conferred by licensed OCVs beyond two years of follow-up has not been demonstrated in randomized, clinical trials.
  25. pmc Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles
    Yvonne A O'Shea
    Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
    J Clin Microbiol 42:4657-71. 2004
    Vibrio cholerae, the causative agent of cholera, is a natural inhabitant of the aquatic ecosystem. We examined a unique collection of V...
  26. ncbi Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis
    Mohammad Ali
    International Vaccine Institute, Seoul, Korea
    Lancet 366:44-9. 2005
    Decisions about the use of killed oral cholera vaccines, which confer moderate levels of direct protection to vaccinees, can depend on whether the vaccines also provide indirect (herd) protection when high levels of vaccine coverage are ..
  27. pmc Improving community coverage of oral cholera mass vaccination campaigns: lessons learned in Zanzibar
    Christian Schaetti
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e41527. 2012
    Recent research in two cholera-endemic communities of Zanzibar has shown that a majority (∼94%) of the adult population was willing to receive free oral cholera vaccines (OCVs)...
  28. ncbi Nepalese origin of cholera epidemic in Haiti
    R R Frerichs
    Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA
    Clin Microbiol Infect 18:E158-63. 2012
    b>Cholera appeared in Haiti in October 2010 for the first time in recorded history...
  29. pmc Understanding the cholera epidemic, Haiti
    Renaud Piarroux
    Universite de la Mediterranee, Marseilles, France
    Emerg Infect Dis 17:1161-8. 2011
    After onset of a cholera epidemic in Haiti in mid-October 2010, a team of researchers from France and Haiti implemented field investigations and built a database of daily cases to facilitate identification of communes most affected...
  30. pmc Cholera in Haiti and other Caribbean regions, 19th century
    Deborah Jenson
    Duke University, Durham, North Carolina 27708, USA
    Emerg Infect Dis 17:2130-5. 2011
    Medical journals and other sources do not show evidence that cholera occurred in Haiti before 2010, despite the devastating effect of this disease in the Caribbean region in the 19th century...
  31. pmc Characterization of toxigenic Vibrio cholerae from Haiti, 2010-2011
    Deborah Talkington
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:2122-9. 2011
    ..These data show that the isolates from Haiti are clonally and genetically similar to isolates originating in Africa and southern Asia and that ctxB-7 and tcpET(CIRS) alleles are undergoing global dissemination...
  32. pmc A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae
    D Ewen Cameron
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8736-41. 2008
    ..Vibrio cholerae strain C6706, a clinical isolate belonging to the O1 El Tor biotype responsible for the current cholera pandemic...
  33. ncbi Review of reported cholera outbreaks worldwide, 1995-2005
    David C Griffith
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 75:973-7. 2006
    The global temporal and spatial distribution of cholera is underappreciated, given the lack of surveillance in endemic areas and economic disincentives to report outbreaks...
  34. ncbi Association between climate variability and hospital visits for non-cholera diarrhoea in Bangladesh: effects and vulnerable groups
    Masahiro Hashizume
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 36:1030-7. 2007
    We estimated the effects of rainfall and temperature on the number of non-cholera diarrhoea cases and identified population factors potentially affecting vulnerability to the effect of the climate factors in Dhaka, Bangladesh.
  35. ncbi Cholera epidemic in Haiti, 2010: using a transmission model to explain spatial spread of disease and identify optimal control interventions
    Ashleigh R Tuite
    Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada
    Ann Intern Med 154:593-601. 2011
    Haiti is in the midst of a cholera epidemic. Surveillance data for formulating models of the epidemic are limited, but such models can aid understanding of epidemic processes and help define control strategies.
  36. ncbi Inapparent infections and cholera dynamics
    Aaron A King
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 454:877-80. 2008
    ..This is true for cholera, a pandemic bacterial disease, where estimates of the ratio of asymptomatic to symptomatic infections have ranged ..
  37. pmc Natural cholera infection-derived immunity in an endemic setting
    Mohammad Ali
    International Vaccine Institute, Seoul, Republic of Korea
    J Infect Dis 204:912-8. 2011
    Live oral cholera vaccines may protect against cholera in a manner similar to natural cholera infections. However, information on which to base these vaccines is limited.
  38. pmc Estimating the reproductive numbers for the 2008-2009 cholera outbreaks in Zimbabwe
    Zindoga Mukandavire
    Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 108:8767-72. 2011
    b>Cholera remains an important global cause of morbidity and mortality, capable of causing periodic epidemic disease. Beginning in August 2008, a major cholera epidemic occurred in Zimbabwe, with 98,585 reported cases and 4,287 deaths...
  39. pmc Considerations for oral cholera vaccine use during outbreak after earthquake in Haiti, 2010-2011
    Kashmira A Date
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:2105-12. 2011
    Oral cholera vaccines (OCVs) have been recommended in cholera-endemic settings and preemptively during outbreaks and complex emergencies. However, experience and guidelines for reactive use after an outbreak has started are limited...
  40. pmc Highly localized sensitivity to climate forcing drives endemic cholera in a megacity
    Robert C Reiner
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 109:2033-6. 2012
    The population dynamics of endemic cholera in urban environments--in particular interannual variation in the size and distribution of seasonal outbreaks--remain poorly understood and highly unpredictable...
  41. pmc The case for reactive mass oral cholera vaccinations
    Rita Reyburn
    International Vaccine Institute IVI, Seoul, Korea
    PLoS Negl Trop Dis 5:e952. 2011
    The outbreak of cholera in Zimbabwe intensified interest in the control and prevention of cholera...
  42. pmc One-step immunochromatographic dipstick tests for rapid detection of Vibrio cholerae O1 and O139 in stool samples
    F Nato
    Institut Pasteur, Paris, France
    Clin Diagn Lab Immunol 10:476-8. 2003
    ..The sensitivity of the dipsticks ranged from 94.2 to 100% when evaluated with stool samples obtained in Madagascar and Bangladesh. The dipstick can provide a simple tool for epidemiological surveys...
  43. pmc Field evaluation of a rapid immunochromatographic dipstick test for the diagnosis of cholera in a high-risk population
    Xuan Yi Wang
    The International Vaccine Institute, Seoul, Korea
    BMC Infect Dis 6:17. 2006
    Early detection of cholera outbreaks is crucial for the implementation of the most appropriate control strategies.
  44. ncbi Oral vaccines against cholera
    Sunheang Shin
    International Vaccine Institute, Seoul, South Korea
    Clin Infect Dis 52:1343-9. 2011
    The current seventh pandemic of cholera, caused by serogroup O1, El Tor biotype, has now involved almost the entire developing world...
  45. pmc Regional-scale climate-variability synchrony of cholera epidemics in West Africa
    Guillaume Constantin de Magny
    Génétique et Evolution des Maladies Infectieuses, UMR CNRS IRD 2724, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 05, France
    BMC Infect Dis 7:20. 2007
    The relationship between cholera and climate was explored in Africa, the continent with the most reported cases, by analyzing monthly 20-year cholera time series for five coastal adjoining West African countries: Côte d'Ivoire, Ghana, ..
  46. pmc Evidence of a dominant lineage of Vibrio cholerae-specific lytic bacteriophages shed by cholera patients over a 10-year period in Dhaka, Bangladesh
    Kimberley D Seed
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    MBio 2:e00334-10. 2011
    Lytic bacteriophages are hypothesized to contribute to the seasonality and duration of cholera epidemics in Bangladesh. However, the bacteriophages contributing to this phenomenon have yet to be characterized at a molecular genetic level...
  47. ncbi Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae
    D Scott Merrell
    Tufts University School of Medicine, Department of Molecular Biology and Microbiology, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Microbiol 43:1471-91. 2002
    ..While cholera toxin and the toxin-coregulated pilus (TCP) are known to be essential for full virulence, the role that other ..
  48. pmc A bistable switch and anatomical site control Vibrio cholerae virulence gene expression in the intestine
    Alex T Nielsen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 6:e1001102. 2010
    ..Vibrio cholerae growth and virulence gene expression during infection of the rabbit ligated ileal loop model of cholera. Genes encoding the toxin-coregulated pilus (TCP) and cholera toxin (CT) were powerfully expressed early in the ..
  49. pmc Lessons learned during public health response to cholera epidemic in Haiti and the Dominican Republic
    Jordan W Tappero
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:2087-93. 2011
    After epidemic cholera emerged in Haiti in October 2010, the disease spread rapidly in a country devastated by an earthquake earlier that year, in a population with a high proportion of infant deaths, poor nutrition, and frequent ..
  50. pmc Transmission dynamics and control of cholera in Haiti: an epidemic model
    Jason R Andrews
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet 377:1248-55. 2011
    Official projections of the cholera epidemic in Haiti have not incorporated existing disease trends or patterns of transmission, and proposed interventions have been debated without comparative estimates of their effect...
  51. pmc Immunization with Vibrio cholerae outer membrane vesicles induces protective immunity in mice
    Stefan Schild
    Department of Molecular Biology and Microbiology, Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Infect Immun 76:4554-63. 2008
    ..These findings may contribute to the development of "nonliving," OMV-based vaccines against V. cholerae and other enteric pathogens, using the oral or intranasal route of immunization...
  52. ncbi Refractory periods and climate forcing in cholera dynamics
    Katia Koelle
    Department of Ecology and Evolutionary Biology, 2045 Kraus Natural Science Building, University of Michigan, 830 North University Avenue, Ann Arbor, Michigan 48109 1048, USA
    Nature 436:696-700. 2005
    Outbreaks of many infectious diseases, including cholera, malaria and dengue, vary over characteristic periods longer than 1 year...
  53. pmc Incidence, virulence factors, and clonality among clinical strains of non-O1, non-O139 Vibrio cholerae isolates from hospitalized diarrheal patients in Kolkata, India
    S Chatterjee
    National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India
    J Clin Microbiol 47:1087-95. 2009
    ..The non-O1, non-O139 strains were nontoxigenic except for an O36 strain (SC124), which regulated expression of cholera toxin as O1 classical strains did...
  54. pmc Host-induced epidemic spread of the cholera bacterium
    D Scott Merrell
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nature 417:642-5. 2002
    ..Water-borne spread of the diarrhoeal disease cholera occurs rapidly in nature, whereas infection of human volunteers with bacteria grown in vitro is difficult in the ..
  55. pmc Cholera in Mozambique, variant of Vibrio cholerae
    M Ansaruzzaman
    Emerg Infect Dis 10:2057-9. 2004
  56. pmc Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae
    Michel A Marin
    Laboratory of Molecular Genetics of Microorganisms, Oswaldo Cruz Institute IOC, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    PLoS Negl Trop Dis 7:e2049. 2013
    The current millennium has seen a steep rise in the number, size and case-fatalities of cholera outbreaks in many African countries. Over 40,000 cases of cholera were reported from Nigeria in 2010...
  57. pmc Dynamics of cholera outbreaks in Great Lakes region of Africa, 1978-2008
    Didier Bompangue Nkoko
    Universite de Franche Comte, Besancon, France
    Emerg Infect Dis 17:2026-34. 2011
    b>Cholera outbreaks have occurred in Burundi, Rwanda, Democratic Republic of Congo, Tanzania, Uganda, and Kenya almost every year since 1977-1978, when the disease emerged in these countries...
  58. pmc Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera
    Mohammad Arifuzzaman
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:1304-11. 2012
    Young children, older children, and adults develop comparable levels and durations of immunity following cholera. In comparison, young children receiving oral killed cholera vaccines (OCV) develop a lower level and shorter duration of ..
  59. pmc Discovery of novel Vibrio cholerae VSP-II genomic islands using comparative genomic analysis
    Elisa Taviani
    Maryland Pathogen Research Institute, University of Maryland, MD, USA
    FEMS Microbiol Lett 308:130-7. 2010
    ..cholerae. Interestingly, one of the new VSP-II revealed the presence of 'old' and 'new' V. cholerae O1 El Tor pandemic clones circulating in some of the areas where cholera is endemic.
  60. pmc Use of oral cholera vaccine in Haiti: a rural demonstration project
    Louise C Ivers
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, Massachusetts Partners In Health, Boston, Massachusetts Zanmi Lasante, St Marc, Haiti Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts Ministry of Health and Population, Port au Prince, Haiti
    Am J Trop Med Hyg 89:617-24. 2013
    A cholera epidemic has claimed the lives of more than 8,000 Haitians and sickened 650,000 since the outbreak began in October 2010...
  61. pmc Epidemic cholera in a crowded urban environment, Port-au-Prince, Haiti
    Stacie E Dunkle
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:2143-6. 2011
    We conducted a case-control study to investigate factors associated with epidemic cholera. Water treatment and handwashing may have been protective, highlighting the need for personal hygiene for cholera prevention in contaminated urban ..
  62. ncbi Genomic evolution of Vibrio cholerae
    Yong Joon Cho
    School of Biological Sciences and Institute of Microbiology, Seoul National University, Gwanak 599 Gwanak ro, Gwanak Gu, Seoul 151 742, Republic of Korea
    Curr Opin Microbiol 13:646-51. 2010
    Vibrio cholera, the causal agent of cholera, also occupies an autochthonous aquatic inhabitant. The current, seventh cholera pandemic is linked to O1 El Tor biotype and O139 serogroups...
  63. ncbi 5 year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: a cluster-randomised, double-blind, placebo-controlled trial
    Sujit K Bhattacharya
    National Institute of Cholera and Enteric Diseases, Kolkata, India Indian Council of Medical Research, New Delhi, India
    Lancet Infect Dis 13:1050-6. 2013
    Efficacy and safety of a two-dose regimen of bivalent killed whole-cell oral cholera vaccine (Shantha Biotechnics, Hyderabad, India) to 3 years is established, but long-term efficacy is not...
  64. pmc The Indian Ocean dipole and cholera incidence in Bangladesh: a time-series analysis
    Masahiro Hashizume
    Institute of Tropical Medicine and Global Center of Excellence Program, Nagasaki University, Nagasaki, Japan
    Environ Health Perspect 119:239-44. 2011
    It has been reported that the El Niño-Southern Oscillation (ENSO) influences the interannual variation of endemic cholera in Bangladesh...
  65. pmc Costs of illness due to endemic cholera
    C Poulos
    Research Triangle Institute, Durham, NC 27709, USA
    Epidemiol Infect 140:500-9. 2012
    Economic analyses of cholera immunization programmes require estimates of the costs of cholera...
  66. ncbi New-generation vaccines against cholera
    John Clemens
    International Vaccine Institute, Seoul National University Research Park, San 4 8, Nakseongdae dong, Kwanak gu, Seoul 151 919, Korea
    Nat Rev Gastroenterol Hepatol 8:701-10. 2011
    b>Cholera is a major global health problem, causing approximately 100,000 deaths annually, about half of which occur in sub-Saharan Africa...
  67. pmc The high burden of cholera in children: comparison of incidence from endemic areas in Asia and Africa
    Jacqueline L Deen
    International Vaccine Institute, Seoul, Korea
    PLoS Negl Trop Dis 2:e173. 2008
    b>Cholera remains an important public health problem. Yet there are few reliable population-based estimates of laboratory-confirmed cholera incidence in endemic areas around the world.
  68. pmc Cholera--modern pandemic disease of ancient lineage
    J Glenn Morris
    University of Florida, Gainesville, Florida 32610 0009, USA edu
    Emerg Infect Dis 17:2099-104. 2011
    b>Cholera has affected humans for at least a millennium and persists as a major cause of illness and death worldwide, with recent epidemics in Zimbabwe (2008-2009) and Haiti (2010)...
  69. ncbi Is cholera disease associated with poverty?
    Arturo Talavera
    Finlay Institute, Havana, Cuba
    J Infect Dev Ctries 3:408-11. 2009
    b>Cholera remains a global threat and is one of the key indicators of social development...
  70. ncbi Severe diarrhea caused by cholera toxin-producing vibrio cholerae serogroup O75 infections acquired in the southeastern United States
    Melissa Tobin-D'Angelo
    Georgia Division of Public Health, Atlanta, Georgia 30303, USA
    Clin Infect Dis 47:1035-40. 2008
    From 2003 through 2007, Vibrio cholerae serogroup O75 strains possessing the cholera toxin gene were isolated from 6 patients with severe diarrhea, including 3 in Georgia, 2 in Alabama, and 1 in South Carolina...
  71. pmc Vibrio cholerae pathogenic clones
    Anna Salim
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Emerg Infect Dis 11:1758-60. 2005
    ..The sixth pandemic clone was well separated from them...
  72. ncbi Global impact of Vibrio cholerae interactions with chitin
    Carla Pruzzo
    Dipartimento di Biologia, Universita di Genova, Corso Europa 26, 16132 Genova, Italy
    Environ Microbiol 10:1400-10. 2008
    ..cholerae interactions with chitin represent a useful model for examination of the role of primary habitat selection in the development of traits that have been identified as virulence factors in human disease...
  73. pmc Diagnostic limitations to accurate diagnosis of cholera
    Munirul Alam
    Enteric and Food Microbiology Laboratory, Laboratory Sciences Division, International Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh
    J Clin Microbiol 48:3918-22. 2010
    ..showed Vibrio cholerae to be the predominant cause, although more than 40% of the suspected cases failed to show cholera etiology by conventional culture methods (CMs)...
  74. pmc Molecular evidence of cholera outbreak caused by a toxigenic Vibrio cholerae O1 El tor variant strain in Kelantan, Malaysia
    Geik Yong Ang
    Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia
    J Clin Microbiol 48:3963-9. 2010
    A total of 20 Vibrio cholerae isolates were recovered for investigation from a cholera outbreak in Kelantan, Malaysia, that occurred between November and December 2009. All isolates were biochemically characterized as V...
  75. ncbi Evaluation of three rapid diagnostic tests for cholera: does the skill level of the technician matter?
    Pavani Kalluri
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Trop Med Int Health 11:49-55. 2006
    To evaluate SMART, Medicos Dip Stick and an Institut Pasteur (IP) cholera dipstick tests for accuracy and ease of use.
  76. pmc Identification of host cell factors required for intoxication through use of modified cholera toxin
    Carla P Guimaraes
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Biol 195:751-64. 2011
    ..to site-specifically attach fluorophores, biotin, and proteins to the C terminus of the A1 subunit (CTA1) of cholera toxin (CTx) in an otherwise correctly assembled and active CTx complex...
  77. pmc Use of dipsticks for rapid diagnosis of cholera caused by Vibrio cholerae O1 and O139 from rectal swabs
    N A Bhuiyan
    Laboratory and Clinical Sciences Divisions, International Centre for Diarrhoeal Diseases Research, Bangladesh ICDDR, B, Dhaka 1212, Bangladesh
    J Clin Microbiol 41:3939-41. 2003
    ..The dipsticks represent the first rapid test which has been successfully used to diagnose cholera from rectal swabs, and this would immensely improve surveillance for cholera, especially in remote settings.
  78. pmc Vibrio cholerae O1 hybrid El Tor strains, Asia and Africa
    Ashrafus Safa
    Emerg Infect Dis 14:987-8. 2008
  79. pmc Cholera outbreaks caused by an altered Vibrio cholerae O1 El Tor biotype strain producing classical cholera toxin B in Vietnam in 2007 to 2008
    Binh Minh Nguyen
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Clin Microbiol 47:1568-71. 2009
    Vibrio cholerae O1 isolates collected during cholera outbreaks occurring from late 2007 to early 2008 in northern Vietnam were revealed to represent an altered strain containing the RS1 element followed by a CTX prophage harboring El Tor ..
  80. pmc Environmental signatures associated with cholera epidemics
    Guillaume Constantin de Magny
    Institute for Advanced Computer Studies, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 105:17676-81. 2008
    The causative agent of cholera, Vibrio cholerae, has been shown to be autochthonous to riverine, estuarine, and coastal waters along with its host, the copepod, a significant member of the zooplankton community...
  81. pmc Controlling endemic cholera with oral vaccines
    Ira M Longini
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e336. 2007
    Although advances in rehydration therapy have made cholera a treatable disease with low case-fatality in settings with appropriate medical care, cholera continues to impose considerable mortality in the world's most impoverished ..
  82. ncbi Vibrio cholerae and cholera: out of the water and into the host
    Joachim Reidl
    Zentrum für Infektionsforschung, Universitat Wurzburg, Wurzburg, Germany
    FEMS Microbiol Rev 26:125-39. 2002
    ..V. cholerae is well recognized and extensively studied as the causative agent of the human intestinal disease cholera. In former centuries cholera was a permanent threat even to the highly developed populations of Europe, North ..
  83. ncbi Cholera in Bangladesh: climatic components of seasonal variation
    Masahiro Hashizume
    Department of International Health, Institute of Tropical Medicine NEKKEN, The Global Center of Excellence program, Nagasaki University, Nagasaki, Japan
    Epidemiology 21:706-10. 2010
    The mechanisms underlying the seasonality of cholera are still not fully understood, despite long-standing recognition of clear bimodal seasonality in Bangladesh...
  84. pmc Characterization of Vibrio cholerae outer membrane vesicles as a candidate vaccine for cholera
    Stefan Schild
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Infect Immun 77:472-84. 2009
    Outer membrane vesicles (OMVs) offer a new approach for an effective cholera vaccine...
  85. ncbi Evaluation of a rapid immunochromatographic dipstick kit for diagnosis of cholera emphasizes its outbreak utility
    Piyali Mukherjee
    Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Jpn J Infect Dis 63:234-8. 2010
    ..This dipstick test has the potential to act as an early warning system for cholera in many developing countries, especially during the start of an outbreak, which would ultimately lead to a ..
  86. pmc The burden of cholera in the slums of Kolkata, India: data from a prospective, community based study
    D Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Arch Dis Child 90:1175-81. 2005
    ..based study in an impoverished urban site in Kolkata (formerly Calcutta) in order to measure the burden of cholera, describe its epidemiology, and search for potential risk factors that could be addressed by public health ..
  87. ncbi Field evaluation of crystal VC Rapid Dipstick test for cholera during a cholera outbreak in Guinea-Bissau
    Julie R Harris
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Trop Med Int Health 14:1117-21. 2009
    ..To evaluate performance characteristics and ease of use of the new commercially available Crystal VC Rapid Dipstick (VC) test (Span Diagnostics, India) for Vibrio cholerae O1 and O139...
  88. pmc New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh
    G Balakrish Nair
    Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 40:3296-9. 2002
    The sixth pandemic of cholera and, presumably, the earlier pandemics were caused by the classical biotype of Vibrio cholerae O1, which was progressively replaced by the El Tor biotype representing the seventh cholera pandemic...
  89. ncbi A rapid, simple, and sensitive loop-mediated isothermal amplification method to detect toxigenic Vibrio cholerae in rectal swab samples
    Kazuhisa Okada
    Thailand Japan Research Collaboration Center on Emerging and Reemerging Infections, DMSc, Ministry of Public Health, Nonthaburi, Thailand
    Diagn Microbiol Infect Dis 66:135-9. 2010
    ..54 CFU/reaction. The method was applied to rectal swab samples from cholera patients and healthy volunteers (19 subjects each) and yielded the same results as the "gold standard" culture ..
  90. pmc Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae
    Ok S Shin
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    MBio 2:e00106-11. 2011
    b>Cholera is a severe diarrheal disease typically caused by O1 serogroup strains of Vibrio cholerae. The pathogenicity of all pandemic V...
  91. pmc Mass vaccination with a two-dose oral cholera vaccine in a refugee camp
    D Legros
    Epicentre, Kampala, Uganda
    Bull World Health Organ 77:837-42. 1999
    In refugee settings, the use of cholera vaccines is controversial since a mass vaccination campaign might disrupt other priority interventions...
  92. ncbi Cholera: a great global concern
    Shyamapada Mandal
    Department of Zoology, Gurudas College, Narkeldanga, Kolkata 700 054, India
    Asian Pac J Trop Med 4:573-80. 2011
    b>Cholera, caused by the infection of toxigenic Vibrio cholerae (V. cholerae) to humans, is a life threatening diarrheal disease with epidemic and pandemic potential. The V...
  93. pmc Investigation of the roles of toxin-coregulated pili and mannose-sensitive hemagglutinin pili in the pathogenesis of Vibrio cholerae O139 infection
    C O Tacket
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 66:692-5. 1998
    ..01). We conclude that TCP are an important colonization factor of V. cholerae O139 and probably of El Tor V. cholerae O1. In contrast, MSHA does not appear to promote intestinal colonization in humans...
  94. pmc The costs of climate change: a study of cholera in Tanzania
    Sara L M Trærup
    UNEP Risø Centre, Risø DTU, P O Box 49, 4000 Roskilde, Denmark
    Int J Environ Res Public Health 8:4386-405. 2011
    ..This study integrates historical data on temperature and rainfall with the burden of disease from cholera in Tanzania and uses socioeconomic data to control for the impacts of general development on the risk of cholera...
  95. pmc Spatially selective colonization of the arthropod intestine through activation of Vibrio cholerae biofilm formation
    Alexandra E Purdy
    Division of Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:19737-42. 2011
    Vibrio cholerae is an estuarine bacterium and the human pathogen responsible for the diarrheal disease cholera. In the environment, arthropods are proposed to be carriers and reservoirs of V. cholerae...
  96. ncbi The tcp gene cluster of Vibrio cholerae
    P A Manning
    Department of Microbiology and Immunology, University of Adelaide, Australia
    Gene 192:63-70. 1997
    ..Experiments using the infant mouse cholera model have now shown that TCP is a colonization factor and protective antigen for both classical and El Tor O1 ..
  97. pmc Local population and regional environmental drivers of cholera in Bangladesh
    Michael Emch
    Department of Geography, University of North Carolina Chapel Hill, USA
    Environ Health 9:2. 2010
    Regional environmental factors have been shown to be related to cholera. Previous work in Bangladesh found that temporal patterns of cholera are positively related to satellite-derived environmental variables including ocean chlorophyll ..
  98. pmc Warming oceans, phytoplankton, and river discharge: implications for cholera outbreaks
    Antarpreet S Jutla
    Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA
    Am J Trop Med Hyg 85:303-8. 2011
    ..has led to an assertion that in a warming climate, rise in SST may increase phytoplankton blooms and, therefore, cholera outbreaks...
  99. pmc Cholera epidemic in Guinea-Bissau (2008): the importance of "place"
    Francisco J Luquero
    Epicentre, Paris, France
    PLoS ONE 6:e19005. 2011
    As resources are limited when responding to cholera outbreaks, knowledge about where to orient interventions is crucial...
  100. ncbi A recombinant probiotic for treatment and prevention of cholera
    Antonio Focareta
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia
    Gastroenterology 130:1688-95. 2006
    ..In the present study, this has been applied to the development of a recombinant probiotic for treatment and prevention of cholera, caused by Vibrio cholerae.
  101. pmc Vibrio cholerae O139 in Calcutta, 1992-1998: incidence, antibiograms, and genotypes
    A Basu
    National Institute of Cholera and Enteric Diseases, Calcutta, India
    Emerg Infect Dis 6:139-47. 2000
    We report results of surveillance for cholera caused by Vibrio cholerae O139 from September 1992, when it was first identified, to December 1998. V...

Research Grants76

  1. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
    ..including: 1) loss of anterograde axonal transport using intravitreal injections of the sensitive neuronal tracer cholera toxin beta subunit (CTB), and 2) axonal degeneration - immunofluorescence in the SC and optic nerve of the ..
  2. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..variety of debilitating and often deadly diarrheal diseases including travelers'diarrhea, dysentery, and cholera. In cholera the primary virulence factors are the toxin- coregulated pilus (TCP), which is required for the ..
  3. Analysis of gene regulation of Vibrio cholerae during infection
    Jun Zhu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Gram-negative bacterium Vibrio cholerae, the causative agent of cholera, is a facultative pathogen that resides in both human and aquatic environments...
  4. Regulation of the Vibrio cholerae intestinal exit plan
    ANISIA J SILVA BENITEZ; Fiscal Year: 2010
    b>Cholera is an acute water-borne diarrheal disease caused by Vibrio cholerae of serogroups O1 and O139. The bacterium is transmitted person-to-person by the fecal oral route...
  5. Biochemistry and Function of a Novel Bacterial Photosensory Two-Component System
    MELISSA MARKS; Fiscal Year: 2010
    ..According to the World Health Organization, over 130,000 cases of cholera (Vibrio cholerae) and 17 million cases of Typhoid fever (Salmonella typhi) occur annually...
  6. Enhanced Membrane Systems for Supplying Quality Drinking Water
    Andrew Feiring; Fiscal Year: 2013
    ..Quality Drinking Water Contaminants in Drinking Water: While many of the traditional waterborne diseases (cholera, typhoid) are now uncommon in the developed world, the continue to be a major cause of disease in developing ..
  7. X-ray Studies of Sugar-Modifying Enzymes
    Hazel Holden; Fiscal Year: 2013
    ..Colitose has been observed, for example, in the O-antigen of Vibrio cholerae, the causative agent of cholera. The quite rare sugar, D-ManNAc3NAcA, has been isolated from the B-band O-antigen of the opportunistic bacterium ..
  8. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..under adverse conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis...
  9. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..cell adhesion molecule, GPI-anchored proteins such as acetylcholinesterase, glycolipids such as the receptor for cholera toxin, components of the cell walls of bacteria and yeast, and the O-antigen of E. coli lipopolysaccharide...
  10. Developing Immunotherapeutics for Methamphetamine Abuse
    THOMAS RICHARD KOSTEN; Fiscal Year: 2010
    ..Four carriers will be compared: Tetanus toxoid, neisseria meningitidis outer membrane protein (OMPC), cholera toxin B and a new lipopeptide based, self-adjuvanting vaccine carrier...
  11. 2012 CSHL Bacteria &Phages Conference
    David J Stewart; Fiscal Year: 2012
    ..under adverse conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis...
  12. The human gut microbiome, malnutrition and vaccine responses
    ANDREW LEON KAU; Fiscal Year: 2013
    ..I will follow their responses to mucosal vaccination with cholera toxin and ovalbumin (a model mucosal adjuvant/antigen) using antigen-specific ELISA...
  13. Vaccines for Sustainable Therapy of Opiate Addiction
    Frank M Orson; Fiscal Year: 2012
    ..Morphine will be conjugated to two highly effective protein carriers: OMPC and cholera toxin b (CTB)...
  14. Prophage-associated virulence factors in pathogenic Neisseria species
    ANNA KARLS; Fiscal Year: 2009
    ..is found at multiple loci on the GC and MC genomes, encodes a potential toxin that is a homologue of the Vibrio cholera CTX prophage zonular occulens toxin (Zot) that alters epithelial and endothelial tight junctions...
  15. The development of probiotic yeast as an inexpensive vaccine delivery platform
    TRACEY JANE LAMB; Fiscal Year: 2013
    ..Although vaccines currently exist to protect against infection with rotavirus and cholera, uptake of these vaccines in developing countries is poor due to the financial cost...
  16. Vibrio cholerae-host interaction at the Intestinal Interface
    Jun Zhu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vibrio cholerae is the etiologic agent of cholera, a devastating dehydrating diarrhea disease endemic in many parts of the world, imposing a significant burden of morbidity and mortality, especially ..
  17. Identification of Inhibitors that Stabilize ER Degradation Substrates
    Domenico Tortorella; Fiscal Year: 2012
    ..g. neuronal ceroid lipofuscinoses and Fabri disease). In addition, toxins such as cholera and ricin toxin have exploited the transport of proteins from the ER to cytosol to gain access to the cytosol and ..
  18. Role of innate immune responses in the activity of an Alphavirus based adjuvant.
    Robert E Johnston; Fiscal Year: 2013
    ..by parenteral immunization is a novel and valuable feature of this adjuvant, and is superior to that achieved by cholera toxin, a model mucosal adjuvant...
  19. Genome Sequencer FLX Instrument
    ANNE VIRGINIA KANE; Fiscal Year: 2010
    ..identify any other unanticipated genome rearrangements will be used in studies of the infectious agents Vibrio cholera, Streptococcus pneumoniae and Legionella pneumophila...
  20. Phages and Genomic Variation in Vibrio Cholerae Evolution
    JOHN JOSEPH MEKALANOS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vibrio cholerae is the causative agent of cholera, an acute life-threatening diarrhea disease...
  21. Protecutive immunity to human cholera in Bangladesh
    Edward T Ryan; Fiscal Year: 2013
    ..Unfortunately, protective immunity following cholera is not currently understood, and available cholera vaccines either fail to produce full protective efficacy or ..
  22. Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.
    ALEXANDRA ELIZABETH PURDY; Fiscal Year: 2010
    b>Cholera, which is caused by ingestion of the Gram-negative pathogen Vibrio cholerae, persists worldwide and affects many thousands of people each year, most of whom do not have access to clean water and sanitary conditions...
  23. Structural Biology of Enterotoxin Secretion from Bacterial Cells
    WILHELMUS G J HOL; Fiscal Year: 2013
    ..Key virulence factors of V. cholerae and ETEC are, respectively, cholera toxin (CT) and Heat-labile Enterotoxin (LT), two closely related and sophisticated hetero-hexameric AB5 toxins...
  24. The Role of MKP-1 in innate immune responses to LPS
    Yusen Liu; Fiscal Year: 2010
    ..cell lineage and cardiomyocytes and resulting damage to the cardiac tissues;2) To test the hypothesis that cholera toxin B subunit, a potent MKP-1-inducing agent, offers protection against LPS-induced mortality...
  25. Regulation of Vibrio cholerae motility, stress response and detachment from intes
    ANISIA J SILVA-BENITEZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cholera is an acute water-borne diarrheal disease caused by Vibrio cholerae of serogroups O1 and O139. Most studies on V...
  26. Retrotranslocation of cholera toxin AI-chain from ER ot cytosol and cell response
    Jin Ah Cho; Fiscal Year: 2010
    ..The overarching goal of this application is to elucidate the molecular basis for retro-translocation of the cholera toxin (CT) A1-chain from within the lumen of the endoplasmic reticulum (ER) of host cells to the cytosol...
  27. DC-T Cell Interactions in Pulmonary Immune Responses
    Anuradha Ray; Fiscal Year: 2012
    ..Our studies show that the allergen house dust mite and the Th2-skewing mucosal adjuvant cholera toxin (CT) induce expression of c-kit and its ligand, stem cell factor, on DCs resulting in high level of ..
  28. Polyamine-dependent regulation of Vibrio cholerae biofilm formation
    Ece Karatan; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Vibrio cholerae is the causative agent of the devastating diarrheal disease cholera. This organism is also a natural inhabitant of aquatic environments worldwide. V...
  29. Interaction between Vibrio cholerae and Dictylostelium discoideum
    SHELLEY M contact PAYNE; Fiscal Year: 2010
    ..Vibrio cholerae, in particular, has a long history of causing epidemic and pandemic cholera. Cholera results from colonization of the small intestine by V...
  30. Epidemiology and Ecology of Vibrio cholerae in Bangladesh
    Richard Bradley Sack; Fiscal Year: 2013
    DESCRIPTION (provided by investigator): Cholera, caused by Vibrio cholerae serogroups O1 and O139, is the most severe of diarrheal diseases and continues to cause significant morbidity and mortality throughout the developing world...
  31. Identifying Host-Factors Required for Toxin Entry and Toxicity
    ERIK HETT; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Many bacterial pathogens produce toxins that cause serious disease including cholera, tetanus, botulism, diphtheria, and anthrax and often share key steps in cell entry and cell death processes that ..
  32. POLLEN GRAINS AS TROJAN HORSES FOR ORAL VACCINATION
    Harvinder Singh Gill; Fiscal Year: 2012
    ..pollen grains were found to be more than ten-fold higher than the anti-ovalbumin IgG levels induced by the use of cholera toxin (CT) as a positive control...
  33. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2013
    ..We used cholera toxin and developed novel derivatives lacking ADP ribosyl transferase activity to circumvent the reactogenicity ..
  34. Pathogenic mechanisms of non-01/non-0139 V. cholerae
    Michelle Dziejman; Fiscal Year: 2012
    Vibrio cholerae is the causative agent of the severe diarrheal disease, cholera, that is endemic in much of Asia, Africa, and South America...
  35. V. cholerae proteins are required for biofilm growth-vaccine targets
    HAVVA FITNAT YILDIZ; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Vibrio cholerae (Vc) causes cholera. Its success as a pathogen depends on appropriate transcriptional regulation in different surroundings, such as the human intestinal tract or the aquatic ..
  36. Suppression of innate immunity by an ADP-ribosyltransferase type III effector
    JAMES ROBERT ALFANO; Fiscal Year: 2012
    ..These genes encode some of the best understood toxins in bacterial pathogens of animals (e. g., cholera toxin)...
  37. Inhibition of Toxin Translocation Can Reverse Cholera and ETEC-Mediated Diarrhea
    KENNETH R TETER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cholera toxin (CT) and heat-labile toxin (LT) from enterotoxigenic Escherichia coli (ETEC) are highly related AB5-type protein toxins composed of an enzymatic A1 subunit, an A2 linker, and a cell-..
  38. Mucosal Adjuvants Targeting Dendritic Cells
    John G Nedrud; Fiscal Year: 2010
    ..The most powerful mucosal adjuvant known is cholera toxin, but adverse side effects preclude the use of holotoxin cholera toxin in humans...
  39. Environmental Modulation of ToxT-dependent Transcription
    KARL KLOSE; Fiscal Year: 2009
    b>Cholera is an often-fatal diarrheal disease caused by the bacterium Vibrio cholerae. This disease remains a health threat for the majority of the world, causing thousands of deaths every year...
  40. Taste representations in the Drosophila brain
    KRISTIN E SCOTT; Fiscal Year: 2012
    ..to target their human hosts and are responsible for the spread of devastating diseases such as malaria, typhoid, cholera and trachoma...
  41. Structural Analysis of Vibrio cholerae Virulence Gene Regulatory Proteins
    FREDRICK JON KULL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vibrio cholerae causes the fatal epidemic diarrheal disease cholera. The expression of its primary virulence factors, toxin-coregulated pilus and cholera toxin, occurs via a transcriptional cascade ..
  42. Development of a live, genetically-attenuated cholera vaccine prototype that coul
    JORGE ANTONIO BENITEZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cholera is an acute, water-borne diarrheal disease caused by the facultative Gram-negative bacterium, Vibrio cholerae of serogroup O1 of the classical and El Tor biotypes and by V...
  43. INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    MARTIN FREDERICK KAGNOFF; Fiscal Year: 2013
    ..tolerance-inducing effects of T regulatory cells and provoke effector T cell immune responses, with a focus on cholera toxin and Th17 differentiation in vitro and in vivo...
  44. Epithelial Glycoconjugates as Barriers against Enteric Infections
    Nicholas J Mantis; Fiscal Year: 2013
    ..Aim 3 will specifically test the proposed hypothesis using well-established mouse models of cholera toxin, ricin toxin, reovirus and Salmonella typhimurium infection.
  45. Characterization of a novel AB5 cytotoxin
    Adrienne W Paton; Fiscal Year: 2011
    ..subunit has distinct enzymic activity and it has no sequence similarity with any of the other AB5 toxin families (cholera, Shiga and pertussis toxins)...
  46. Effects of Climate Change on Cholera Dynamics and Prediction
    Shafiqul Islam; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cholera has reemerged as a global killer with the world witnessing an unprecedented rise in cholera infection and transmission over the past two decades...
  47. Signal Transduction in the Major Quorum-Sensing Circuit of Vibrio cholerae
    Wai Leung Ng; Fiscal Year: 2013
    ..The human pathogen Vibrio cholerae, the causative agent of the disease cholera, regulates virulence factor production and biofilm formation through quorum sensing via a new class of ..
  48. Mass Spectrometric Characterization of Lipopolysaccharides
    Jennifer S Brodbelt; Fiscal Year: 2013
    ..now recognized as the primary cause of peptic ulcer disease and gastric cancer, Camphorbacter jejuni and Vibrio cholera remain among the most common causes of diarrheal illness, and Acinetobacter baumannii is responsible for a ..
  49. Nociceptive Role of SST and NT receptor-expressing dorsal horn neurons
    RONALD GORDON WILEY; Fiscal Year: 2013
    ..of tonically activating sst2a receptor-expressing SDH interneurons with lumbar intrathecal injection of SST-cholera toxin A subunit conjugate (SST-CTA) in normal rats and rat models of chronic inflammatory and neuropathic pain;..
  50. Imaging antigen and adjuvant uptake for enhancing response to mucosal vaccines
    Michael W Russell; Fiscal Year: 2012
    ..numerous strategies designed to enhance responses to mucosal vaccines, bacterial heat-labile enterotoxins such as cholera toxin (CT) and the labile toxins of Escherichia coli (LT-I, LT-IIa and LT-IIb) have been exploited as both ..
  51. Zebrafish as a natural host model for Vibrio cholerae
    Jeffrey H Withey; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Vibrio cholerae are aquatic bacteria that cause the severe diarrheal disease cholera when ingested by humans in contaminated water...
  52. High-throughput proteomic study of protective immunity in human cholera infection
    Richelle C Charles; Fiscal Year: 2013
    ..The major project focus will be the application of immuno-proteomics to the study of protective immunity in human cholera infection, an infection that remains endemic in over 50 countries...
  53. High throughput NAPPA-proteoimmunomics and Vibrio cholerae vaccine development
    Edward T Ryan; Fiscal Year: 2012
    ..Vibrio cholerae is a category B agent, and the cause of cholera, a secretary diarrhea that results in significant morbidity and mortality worldwide...
  54. Mechanism of cholera toxin retro-translocation
    Billy Tsai; Fiscal Year: 2013
    ..However, the molecular basis of infection, in many cases, remains enigmatic. Cholera toxin (CT) produced by Vibrio cholerae is the virulence factor responsible for massive secretory diarrhea...
  55. TYPE II Enterotoxins as Mucosal Immunomodulators
    Terry D Connell; Fiscal Year: 2011
    ..exerts immunostimulatory effects using immune pathways and cellular receptors different from those employed by cholera toxin (CT), LT (LT-I) of E. coli, and other mucosal adjuvants...
  56. LIVE-CELL IMAGING OF CFTR OLIGOMERIZATION, TRAFFICKING AND INTERACTIONS
    PETER MICHAEL HAGGIE; Fiscal Year: 2012
    ..including cystic fibrosis, polycystic kidney disease and enterotoxin-induced secretory diarrheas such as cholera. The long-term objective of this proposal is to use live cell fluorescence imaging to address key unresolved ..
  57. Intestinal Disease-enterocyte toxin interaction
    Wayne Lencer; Fiscal Year: 2013
    ..goal of this application is to elucidate the molecular basis for invasion and intoxication of intestinal cells by cholera toxin (CT), the causative agent of Asiatic cholera, and for induction of innate immunity...
  58. Enhancing DNA vaccines using modified Bacterial Toxin A1 Subunits as adjuvants
    Timothy R Fouts; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cholera toxin (CT) and the related heat-labile enterotoxin (LT) are AB toxins with cell targeting B domains and enzymatically active A domains...
  59. A novel cholera subunit vaccine based on 4 colonization factors
    WILLIAM FRANKLIN WADE; Fiscal Year: 2010
    A novel approach is proposed to develop a cholera subunit vaccine based on the current understanding of Vibrio cholerae (Vc) colonization, pathogenesis, and the human immune response to cholera...
  60. Estimation of Intervention Effects in Influenza Outbreaks
    Justin Lessler; Fiscal Year: 2012
    ..Cummings and Dr. Bryan Grenfell in an analysis of the effectiveness of reactive vaccination in cholera outbreaks, thereby increasing his abilities in the modeling of infectious disease and the assessment of ..
  61. O-Specific Polysaccharide Responses and Cholera
    Edward T Ryan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cholera is a severe dehydrating disease caused by Vibrio cholerae...
  62. Functional characterization of Rho inactivation by Vibro cholerae RTX toxin
    BRETT L GEISSLER; Fiscal Year: 2010
    Vibrio cholerae is responsible for causing the life-threatening diarrheal disease cholera. The World Health Organization confirmed 236,896 cases and 6,311 deaths from cholera in 2006. V...
  63. MAST CELL MEMBRANE GLYCOLIPID EXPRESSION AND FUNCTION
    Michael Raizman; Fiscal Year: 1991
    ..is designed to learn more about mast cell differentiation through studies of the expression and function of a cholera toxin-binding glycosphingolipid, ganglisoside GM1, on mouse mast cells at different stages of development...
  64. ESCHERICHIA COLI LT-RELATED ENTEROTOXINS
    RICHARD FINKELSTEIN; Fiscal Year: 1991
    ..diarrheagenic enterotoxins which are structurally, functionally and immunologically related to the prototype, the cholera entertoxin (a.k.a. choleragen, cholera toxin, or CT), which was first isolated to homogeneity in 1969...
  65. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Cholera, and related diarrheal diseases, are the #3 cause of all deaths worldwide...
  66. ROLE OF AEROMONAS HYDROPHILA VIRULENCE FACTORS
    CLIFFORD HOUSTON; Fiscal Year: 1992
    ..hydrophila mediated diseases. We have termed one of these toxins "cholera-toxin crossreactive (CTC) cytolysin" because of its ability to react with cholera antitoxin and cause fluid ..
  67. SIGNAL TRANSDUCTION IN T CELLS
    CONSTANTINE TSOUKAS; Fiscal Year: 1991
    ..in membranes of human T cells by using 32p-NAD and by taking advantage of the ability of bacterial toxins (cholera and pertussis toxin) to specifically ADP- ribosylate the Alpha subunits in vitro using the radioactive NAD as a ..
  68. NEW MECHANISMS FOR REGULATING VIRULENCE GENE EXPRESSION
    Karen Skorupski; Fiscal Year: 2001
    ..For the human pathogen Vibrio cholerae, the coordinate expression of cholera toxin (CT), toxin-coregulated pilus (TCP), and a number of other virulence factors is strongly influenced by ..
  69. MOLECULAR MODE OF ACTION OF BACTERIAL ENTEROTOXINS
    JOHNNY PETERSON; Fiscal Year: 1999
    ..The applicant's overall research objective is to define essential components in the mechanism of action of cholera toxin (CT) on water and electrolyte secretion in the small intestine...
  70. ADP RIBOSYLATION OF A POTENT INDUCER OF PROLIFERATION
    Mark Francis; Fiscal Year: 2002
    ..Based on his previous work, the applicant hypothesizes that cholera toxin ADP-ribosylates a non-Gs protein that regulates B cell activation...
  71. GLYCOSPHINGOLIPIDS AND GM1-CHOLERA TOXIN INTERACTIONS
    G Shipley; Fiscal Year: 2000
    ..membrane lipids, and (3) the role of GSL as receptors for bacterial toxins, with emphasis on the ganglioside GM1-cholera toxin system...
  72. ACCESSORY CHOLERA ENTEROTOXIN, ACE, MECHANISM OF ACTION
    Michele Trucksis; Fiscal Year: 2006
    ..by applicant): Colonization of the small intestine by Vibrio cholerae causes the potentially lethal disease cholera due to massive salt and water secretion...
  73. POPULATION BIOLOGY OF SURFACE POLYSACCHARIDES IN CHOLERA
    John Morris; Fiscal Year: 2004
    b>Cholera is an ancient disease in the midst of a modern resurgence, with cases reported to WHO by 65 member nations in Asia, Africa, the Americas, and Europe in 1997. With the appearance of V...
  74. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts
    David E Saslowsky; Fiscal Year: 2010
    ..b>Cholera toxin (CT), the causative agent of Asiatic cholera, typifies the structure and function of the AB5-subunit toxins ..
  75. Retro-translocation of cholera toxin in intestinal cells: from ER to cytosol
    NAOMI WERNICK; Fiscal Year: 2009
    ..by applicant): The goal of this application is to elucidate the molecular basis for retro-translocation of the cholera toxin (CT) A1-chain from within the lumen of the endoplasmic reticulum (ER) to the cytosol...
  76. Accessory toxin-mediated evasion of innate immunity during V. cholerae infection
    Karla J F Satchell; Fiscal Year: 2010
    Vibrio cholerae O1 is the causative agent of pandemic cholera, a severe diarrheal disease still prevalent worldwide...