vibrio infections

Summary

Summary: Infections with bacteria of the genus VIBRIO.

Top Publications

  1. doi Nonfoodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997-2006
    Amy M Dechet
    AIDS Education and Training Center, San Francisco General Hospital, San Francisco, California, USA
    Clin Infect Dis 46:970-6. 2008
  2. doi Vibrio tapetis-like strain isolated from introduced Manila clams Ruditapes philippinarum showing symptoms of brown ring disease in Norway
    Christine Paillard
    Institut Universitaire Europeen de la Mer, LEMAR, UMR 6539, Universite de Bretagne Occidentale, 29280 Plouzane, France
    Dis Aquat Organ 81:153-61. 2008
  3. pmc Vibrio parahaemolyticus cell biology and pathogenicity determinants
    Christopher A Broberg
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas TX 75390 9148, USA
    Microbes Infect 13:992-1001. 2011
  4. pmc Whole transcriptome profiling of successful immune response to Vibrio infections in the oyster Crassostrea gigas by digital gene expression analysis
    Julien de Lorgeril
    Institut Francais de Recherche pour l Exploitation de la Mer, Centre National de la Recherche Scientifique, Montpellier, France
    PLoS ONE 6:e23142. 2011
  5. doi Pathogenic Vibrio harveyi, in contrast to non-pathogenic strains, intervenes with the p38 MAPK pathway to avoid an abalone haemocyte immune response
    Marie Agnès Travers
    France Haliotis, Kerazan, Lilia, 29880 Plouguerneau, France
    J Cell Biochem 106:152-60. 2009
  6. pmc Contribution of Vibrio parahaemolyticus virulence factors to cytotoxicity, enterotoxicity, and lethality in mice
    Hirotaka Hiyoshi
    Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Infect Immun 78:1772-80. 2010
  7. pmc Epidemiology of Vibrio parahaemolyticus outbreaks, southern Chile
    Erika Harth
    Universidad de Chile, Santiago, Chile
    Emerg Infect Dis 15:163-8. 2009
  8. pmc Vibrio vulnificus rtxA1 gene recombination generates toxin variants with altered potency during intestinal infection
    Jayme S Kwak
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 108:1645-50. 2011
  9. doi Vibriosis vaccines based on various sero-subgroups of Vibrio anguillarum O2 induce specific protection in Atlantic cod (Gadus morhua L.) juveniles
    Helene Mikkelsen
    NOFIMA Marin, PO Box 6122, N 9291 Tromsø, Norway
    Fish Shellfish Immunol 30:330-9. 2011
  10. doi Differential expression and biological activity of two piscidin paralogues and a novel splice variant in Atlantic cod (Gadus morhua L.)
    Jareeporn Ruangsri
    Faculty of Biosciences and Aquaculture, University of Nordland, Mørkved, 8049 Bodø, Norway
    Fish Shellfish Immunol 32:396-406. 2012

Detail Information

Publications225 found, 100 shown here

  1. doi Nonfoodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997-2006
    Amy M Dechet
    AIDS Education and Training Center, San Francisco General Hospital, San Francisco, California, USA
    Clin Infect Dis 46:970-6. 2008
    ..Like foodborne Vibrio infections, nonfoodborne Vibrio infections (NFVI) also result in serious illness, but awareness of these infections is ..
  2. doi Vibrio tapetis-like strain isolated from introduced Manila clams Ruditapes philippinarum showing symptoms of brown ring disease in Norway
    Christine Paillard
    Institut Universitaire Europeen de la Mer, LEMAR, UMR 6539, Universite de Bretagne Occidentale, 29280 Plouzane, France
    Dis Aquat Organ 81:153-61. 2008
    ..8% similarity) and the Cpn60 encoding gene had 22 substitutions out of 548 nt compared (96% similarity). This is the first finding of BRD and the first isolation of a V. tapetis-like bacterial strain from a bivalve in Norway...
  3. pmc Vibrio parahaemolyticus cell biology and pathogenicity determinants
    Christopher A Broberg
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas TX 75390 9148, USA
    Microbes Infect 13:992-1001. 2011
    ..The following describes the known pathogenicity determinants while establishing the need for continued research...
  4. pmc Whole transcriptome profiling of successful immune response to Vibrio infections in the oyster Crassostrea gigas by digital gene expression analysis
    Julien de Lorgeril
    Institut Francais de Recherche pour l Exploitation de la Mer, Centre National de la Recherche Scientifique, Montpellier, France
    PLoS ONE 6:e23142. 2011
    ..gigas immune responsiveness to circumvent Vibrio infections, we have developed the first deep sequencing study of the transcriptome of hemocytes, the immunocompetent ..
  5. doi Pathogenic Vibrio harveyi, in contrast to non-pathogenic strains, intervenes with the p38 MAPK pathway to avoid an abalone haemocyte immune response
    Marie Agnès Travers
    France Haliotis, Kerazan, Lilia, 29880 Plouguerneau, France
    J Cell Biochem 106:152-60. 2009
    ..Taken together, our results suggest that p38 MAPK modulation may be one of the ways of virulent V. harveyi to attack its host and escape abalone immune response...
  6. pmc Contribution of Vibrio parahaemolyticus virulence factors to cytotoxicity, enterotoxicity, and lethality in mice
    Hirotaka Hiyoshi
    Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Infect Immun 78:1772-80. 2010
    ..Our findings provide new indications that these virulence factors contribute to and orchestrate each distinct aspect of the pathogenicity of V. parahaemolyticus...
  7. pmc Epidemiology of Vibrio parahaemolyticus outbreaks, southern Chile
    Erika Harth
    Universidad de Chile, Santiago, Chile
    Emerg Infect Dis 15:163-8. 2009
    ..parahaemolyticus groups comprising the diverse and shifting bacterial population in shellfish in this region...
  8. pmc Vibrio vulnificus rtxA1 gene recombination generates toxin variants with altered potency during intestinal infection
    Jayme S Kwak
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 108:1645-50. 2011
    ..This finding would imply further that in the future on-going genetic variation of the MARTX(Vv) toxins could result in the emergence of novel strains with altered virulence in humans...
  9. doi Vibriosis vaccines based on various sero-subgroups of Vibrio anguillarum O2 induce specific protection in Atlantic cod (Gadus morhua L.) juveniles
    Helene Mikkelsen
    NOFIMA Marin, PO Box 6122, N 9291 Tromsø, Norway
    Fish Shellfish Immunol 30:330-9. 2011
    ..However, in groups vaccinated against V. anguillarum sero-subgroups O2b or O2, IL-12p40 and IFNγ gene expression were slightly increased 3 and 55 days post vaccination, respectively...
  10. doi Differential expression and biological activity of two piscidin paralogues and a novel splice variant in Atlantic cod (Gadus morhua L.)
    Jareeporn Ruangsri
    Faculty of Biosciences and Aquaculture, University of Nordland, Mørkved, 8049 Bodø, Norway
    Fish Shellfish Immunol 32:396-406. 2012
    ..Moreover, the two pis paralogues have undergone structural diversification and it is likely that they play multifunctional roles in Atlantic cod...
  11. doi The major outer membrane protein OmpU of Vibrio splendidus contributes to host antimicrobial peptide resistance and is required for virulence in the oyster Crassostrea gigas
    Marylise Duperthuy
    CNRS, UMR 5119, Laboratoire Ecosystèmes Lagunaires, Universite Montpellier 2, 34095 Montpellier, France
    Environ Microbiol 12:951-63. 2010
    ..splendidus. Contributing to AMP resistance, conferring adhesive properties to V. splendidus, and being essential for in vivo fitness, the OmpU porin appears as an essential effector of the C. gigas/V. splendidus interaction...
  12. pmc Development of two animal models to study the function of Vibrio parahaemolyticus type III secretion systems
    Pablo Piñeyro
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 78:4551-9. 2010
    ..The two models introduced herein produce robust results and provide a means to determine how different T3SS1 and T3SS2 effector proteins contribute to pathogenesis of V. parahaemolyticus infection...
  13. pmc Population structures of two genotypes of Vibrio vulnificus in oysters (Crassostrea virginica) and seawater
    Elizabeth Warner
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Appl Environ Microbiol 74:80-5. 2008
    ..Levels of the two genotypes as well as seasonal dynamics within both oyster tissue and the surrounding waters may aid in identifying risk factors associated with human infection...
  14. pmc Isolation and characterization of a Vibrio vulnificus mutant deficient in both extracellular metalloprotease and cytolysin
    J J Fan
    Department of Microbiology and Immunology, College of Medicine, National Cheng-Kung University, Tainan 701, Taiwan, Republic of China
    Infect Immun 69:5943-8. 2001
    ..The cytolysin, but not the protease, seemed to be important for causing damage in the alimentary tract of the mice...
  15. doi Characteristics of a pandemic clone of O3 : K6 and O4 : K68 Vibrio parahaemolyticus isolated in Beira, Mozambique
    M Ansaruzzaman
    ICDDR, B International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka 1212, Bangladesh
    J Med Microbiol 57:1502-7. 2008
    ..The O3 : K58 (n=8), O4 : K13 (n=6), O3 : KUT (n=1) and O8 : K41 (n=1) strains showed unique characteristics different from the pandemic clone...
  16. ncbi An inhibitor of bacterial quorum sensing reduces mortalities caused by Vibriosis in rainbow trout (Oncorhynchus mykiss, Walbaum)
    Maria Rasch
    Danish Institute for Fisheries Research, Department of Seafood Research, Søltofts Plads, c o Technical University of Denmark, Lyngby, Denmark
    Syst Appl Microbiol 27:350-9. 2004
    ..However, they also underline the need for development of novel, less toxic QSI compounds and the need for understanding the exact mechanism(s) of action...
  17. ncbi Survival of Vibrio vulnificus in whole blood from patients with chronic liver diseases: association with phagocytosis by neutrophils and serum ferritin levels
    L I Hor
    Department of Microbiology, Department of Internal Medicine, National Cheng Kung Univesity, Tainan, Taiwan
    J Infect Dis 179:275-8. 1999
    ..198; P<.05) and phagocytosis by neutrophils (r=-.204; P<.05). Among these parameters, low phagocytosis activity (P<.01) and high ferritin level (P<.01) in the blood were the independent predictors...
  18. pmc Molecular analysis of the emergence of pandemic Vibrio parahaemolyticus
    E Fidelma Boyd
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    BMC Microbiol 8:110. 2008
    ..This new highly virulent strain is now globally disseminated...
  19. doi Vibrio anguillarum as a fish pathogen: virulence factors, diagnosis and prevention
    I Frans
    Laboratory for Process Microbial Ecology and Bioinspirational Management, Consortium for Industrial Microbiology and Biotechnology, Department of Microbial and Molecular Systems, K U Leuven Association, Lessius Mechelen, Sint Katelijne Waver, Belgium
    J Fish Dis 34:643-61. 2011
    ..This review summarizes the current state of knowledge pertaining to V. anguillarum, focusing on pathogenesis, known virulence factors, diagnosis, prevention and treatment...
  20. ncbi Phospholipase A as a potent virulence factor of Vibrio vulnificus
    Bon Sun Koo
    Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561 756, Korea
    Int J Mol Med 20:913-8. 2007
    ..These results indicate that PLA activity is important in V. vulnificus-induced cytotoxicity and lethality, suggesting a crucial role for PLA in the pathogenesis of V. vulnificus infection...
  21. pmc Evaluation of typing of vibrio parahaemolyticus by three PCR methods using specific primers
    H C Wong
    Department of Microbiology, Soochow University, Taipei, Taiwan, Republic of China
    J Clin Microbiol 39:4233-40. 2001
    ..REP-PCR is preferable to ERIC-PCR because of the greater reproducibility of its fingerprints, while RS-PCR may be a practical method because it generates fewer amplification bands and patterns than the alternatives...
  22. pmc Multiple-locus variable-number tandem-repeat analysis for clonal identification of Vibrio parahaemolyticus isolates by using capillary electrophoresis
    Erika Harth-Chu
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre of Infection Research, Braunschweig, Germany
    Appl Environ Microbiol 75:4079-88. 2009
    ..The developed approach enables rapid and high-resolution analysis of V. parahaemolyticus with pandemic potential and provides a new surveillance tool for food-borne pathogens...
  23. pmc Role of iron in human serum resistance of the clinical and environmental Vibrio vulnificus genotypes
    Ryan W Bogard
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Appl Environ Microbiol 73:7501-5. 2007
    ..This suggests that the nutrient/osmotic environment may influence the survival of V. vulnificus following entry into the human body, leading to selection of the C genotype over the E genotype...
  24. doi RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis
    Horng Ren Lo
    Institute of Basic Medical Sciences, Taiwan, Republic of China
    J Infect Dis 203:1866-74. 2011
    ..These findings suggest that the RTX of V. vulnificus is required for bacterial survival during infection by protecting the organism from phagocytosis...
  25. ncbi The cytotoxin-hemolysin genes of human and eel pathogenic Vibrio vulnificus strains: comparison of nucleotide sequences and application to the genetic grouping
    Mitsutoshi Senoh
    Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Japan
    Microbiol Immunol 49:513-9. 2005
    ..These findings may lead to development of a novel genetic grouping system related to the virulence potential or to the host range...
  26. doi A relationship between antimicrobial peptide gene expression and capacity of a selected shrimp line to survive a Vibrio infection
    Julien de Lorgeril
    IFREMER, CNRS, Universite de Montpellier II, UMR 5119 Ecosystèmes Lagunaires, Place Eugene Bataillon, CC80, 34095 Montpellier Cedex 5, France
    Mol Immunol 45:3438-45. 2008
    ....
  27. pmc Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis
    Dara L Burdette
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:12497-502. 2008
    ..Our studies reveal an infection paradigm whereby an extracellular pathogen uses its type III secretion system to cause at least three parallel events that eventually result in the proinflammatory death of an infected host cell...
  28. doi RtxA1-induced expression of the small GTPase Rac2 plays a key role in the pathogenicity of Vibrio vulnificus
    Kyoung Jin Chung
    School of Dentistry, Dental Science Research Institute, The 2nd Stage of Brain Korea 21 for the Dental School, Chonnam National University, Republic of Korea
    J Infect Dis 201:97-105. 2010
    ..vulnificus mutant was unable to induce ROS generation within the intestine and failed to cause death. These findings strongly suggest that RtxA1-induced Rac2 expression is a critical step underlying the pathogenicity of V. vulnificus...
  29. pmc Identification of an iron-regulated hemin-binding outer membrane protein, HupO, in Vibrio fluvialis: effects on hemolytic activity and the oxidative stress response
    Sun Hee Ahn
    Department of Biotechnology and Bioengineering, Pukyong National University, Busan 608 737, Republic of Korea
    Infect Immun 73:722-9. 2005
    ..fluvialis through stimulation of hemolysin production and resistance to oxidative stress. In experimentally infected mice, the 50% lethal dose value of the wild-type was lower than that of the mutant, HP1...
  30. pmc Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis
    Dara L Burdette
    Department of Molecular Biology, University of Texas South Western Medical Center, Dallas, TX 75390, USA
    Mol Microbiol 73:639-49. 2009
    ..parahaemolyticus during infection. These data provide important insights into the mechanism used by V. parahaemolyticus to cause disease...
  31. ncbi Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPOBox 128, Dhaka 1000, Bangladesh
    J Infect Dis 187:1085-96. 2003
    ..Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting...
  32. pmc Evaluation of genotypic and phenotypic methods to distinguish clinical from environmental Vibrio vulnificus strains
    Eva Sanjuan
    Departamento de Microbiologia y Ecologia, Universidad de Valencia, Avda Dr Moliner 50, 46100 Burjassot, Valencia, Spain
    Appl Environ Microbiol 75:1604-13. 2009
    ..vulnificus, which suggests that new typing methodologies useful for public health have to be developed for this species...
  33. ncbi Necrotising fasciitis and myositis that originated from gastrointestinal bacterial infection: two fatal cases
    Masaki Fujioka
    Departments of Plastic and Reconstructive Surgery, Fukuoka Tokushukai Medical Center, Fukuoka, Japan
    Scand J Plast Reconstr Surg Hand Surg 37:239-42. 2003
    ..The first patient developed necrosis of the legs over 5 days and he died on the 20th day. Vibrio vulnificus was cultured. The second patient developed bullae on his thigh and he died the next day. Streptococcus pyogenes was cultured...
  34. pmc Population genetics of Vibrio vulnificus: identification of two divisions and a distinct eel-pathogenic clone
    Michaela Gutacker
    Istituto Cantonale di Microbiologia, 6501 Bellinzona, Switzerland
    Appl Environ Microbiol 69:3203-12. 2003
    ..The significance of the two divisions (divisions I and II) still remains to be clarified, and a reevaluation of the definition of the biotypes is also needed...
  35. pmc Identification of the emerging pathogen Vibrio vulnificus biotype 3 by commercially available phenotypic methods
    Raul Colodner
    Clinical Microbiology Laboratory, Ha Emek Medical Center, Afula 18101, Israel
    J Clin Microbiol 42:4137-40. 2004
    ..Data on the phenotypic pattern of V. vulnificus biotype 3 when processed in all five systems as presented here could help clinical laboratories in identifying this new pathogen...
  36. doi Variation of extracellular proteases produced by Vibrio vulnificus clinical isolates: genetic diversity of the metalloprotease gene (vvp), and serine protease secretion by vvp-negative strains
    Jiyou Wang
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Microb Pathog 44:494-500. 2008
    ..These findings suggest that, in addition to metalloprotease, the extracellular serine protease may contribute to pathogenicity of V. vulnificus...
  37. pmc Biodiversity of vibrios
    Fabiano L Thompson
    Laboratory of Microbiology, Ghent University, K L Ledeganckstraat 35, Ghent 9000, Belgium
    Microbiol Mol Biol Rev 68:403-31, table of contents. 2004
    ..g., microarrays will facilitate the investigation of the gene repertoire at the species level. Based on such new genomic information, the taxonomy and the species concept for vibrios will be reviewed in the next years...
  38. doi Inactivation of mismatch repair increases the diversity of Vibrio parahaemolyticus
    Tracy H Hazen
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Environ Microbiol 11:1254-66. 2009
    ..This study is the first to report a higher frequency of natural mutators among Vibrio environmental strains and to provide evidence that inactivation of MMR increases the diversity of V. parahaemolyticus...
  39. pmc Homodimerization and binding of specific domains to the target DNA are essential requirements for HlyU to regulate expression of the virulence gene rtxA1, encoding the repeat-in-toxin protein in the human pathogen Vibrio vulnificus
    Moqing Liu
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    J Bacteriol 193:6895-901. 2011
    ..We also determined that HlyU homodimer formation is an essential requirement for binding to the upstream region of the rtxA1 operon and is the key feature in relieving the H-NS repression of rtxA1 transcription...
  40. pmc Pandemic Vibrio parahaemolyticus O3:K6 spread, France
    Marie Laure Quilici
    Emerg Infect Dis 11:1148-9. 2005
  41. doi Identification of Vibrio harveyi as a causative bacterium for a tail rot disease of sea bream Sparus aurata from research hatchery in Malta
    S Haldar
    International Prevention of Epidemics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 58, Rinkuourai Kita, Izumisano, Osaka, Japan
    Microbiol Res 165:639-48. 2010
    ..Although V. harveyi was reported to be an important pathogen for many aquatic organisms, to our knowledge this might be the first report of disease caused by V. harveyi and their systematic study in the sea bream hatchery from Malta...
  42. doi Clinical features of Vibrio vulnificus infections in the coastal areas of the Ariake Sea, Japan
    Kouichi Matsumoto
    Ariake Sea Research Project, Saga University, Saga, Japan
    J Infect Chemother 16:272-9. 2010
    ..The prognosis of this disease is poor, because septic shock and necrotizing fasciitis often develop within a few days. Early diagnosis and treatment are needed to improve the prognosis of V. vulnificus infection...
  43. doi Immunohistochemistry of Atlantic cod larvae Gadus morhua experimentally challenged with Vibrio anguillarum
    Ane Rebecca Engelsen
    Institute of Marine Research, PO Box 1870 Nordnes, 5817 Bergen, Norway
    Dis Aquat Organ 80:13-20. 2008
    ..Only 2 larvae from the low-challenge dose group showed clear signs of histopathology, which occurred in the intestine. It is not possible to draw any conclusions regarding the portal of entry...
  44. doi Characterization of clinical and environmental types of Vibrio vulnificus isolates from Louisiana oysters
    Feifei Han
    Department of Food Science, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA
    Foodborne Pathog Dis 6:1251-8. 2009
    ..vulnificus. The study also highlighted the need to identify unique virulence markers in this organism, which could facilitate future screening of virulent V. vulnificus strains from oysters...
  45. ncbi [A collective review of Vibrio vulnificus infection in Japan]
    Hirotaka Oishi
    Ariake Sea Research Project, Saga University
    Kansenshogaku Zasshi 80:680-9. 2006
    ..It is also highly recommended that patients with preexisting liver dysfunction avoid raw fish and limit exposure to marine water during the summer...
  46. ncbi Mucosal response in African catfish after administration of Vibrio anguillarum O2 antigens via different routes
    Stefaan Vervarcke
    Laboratorium voor Farmacotechnologie en Biofarmacie, Katholieke Universiteit Leuven, Campus Gasthuisberg O N, Herestraat 49, 3000 Leuven, Belgium
    Fish Shellfish Immunol 18:125-33. 2005
    ..The results obtained are a strong indication for mucosal immune response and the two compartmental models for immune response in fish...
  47. ncbi Vibrio infections in Louisiana: twenty-five years of surveillance 1980-2005
    Annu Thomas
    Infectious Disease Epidemiology Section, Louisiana Office of Public Health, USA
    J La State Med Soc 159:205-8, 210-1. 2007
    A total of 1,007 Vibrio infections were reported to the Infectious Disease Epidemiology Department at the Louisiana Office of Public Heath, between 1980 and 2005...
  48. ncbi The growth of Vibrio vulnificus and the habitat of infected patients in Kumamoto
    Yuji Inoue
    Department of Dermatology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 1:134-9. 2007
    ..vulnificus. Therefore, investigating these geographical and meteorological factors can help predict areas with a higher number of V. vulnificus infection outbreaks...
  49. ncbi Lower extremity infections by vibrio vulnificus
    G Mouzopoulos
    Department of Evangelismos Hospital, Athens, Greece
    Chirurgia (Bucur) 103:201-3. 2008
    ..Vibrio vulnificus is a Gram-negative pathogen which is found in seawater and shellfish during warm months and can cause local infections in healthy individuals or septicemia in patients with chronic liver disease...
  50. doi Epidemiological survey of Vibrio vulnificus infection in Japan between 1999 and 2003
    Yuji Inoue
    Department of Dermatology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 35:129-39. 2008
    ..1%) suffered from liver cancer. The incidence of V. vulnificus infection was different according to districts. Geographic and climatic factors also contributed to the occurrence of V. vulnificus infection...
  51. pmc Necrotizing fasciitis from Vibrio vulnificus in a patient with undiagnosed hepatitis and cirrhosis
    Kenneth L Muldrew
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Microbiol 45:1058-62. 2007
    ..Significant risk factors for severe disease include preexisting liver disease. We report a case of Vibrio vulnificus necrotizing fasciitis in a patient with previously undiagnosed chronic hepatitis and cirrhosis...
  52. pmc Dynamics of clinical and environmental Vibrio parahaemolyticus strains during seafood-related summer diarrhea outbreaks in southern Chile
    Katherine García
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, El Libano 5524, Macul, Santiago 6903625, Chile
    Appl Environ Microbiol 75:7482-7. 2009
    ..parahaemolyticus pathogenic strains become evident...
  53. pmc Association of pandemic Vibrio parahaemolyticus O3:K6 present in the coastal environment of Northwest Mexico with cases of recurrent diarrhea between 2004 and 2010
    Jorge Velazquez-Roman
    Seccion de Posgrado, Escuela Superior de Medicina IPN, Mexico City, Mexico
    Appl Environ Microbiol 78:1794-803. 2012
    ....
  54. ncbi Multiplex PCR detection of clinical and environmental strains of Vibrio vulnificus in shellfish
    Gitika Panicker
    Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294 1170, USA
    Can J Microbiol 50:911-22. 2004
    ..The rapid, sensitive, and specific detection of clinically important pathogenic V. vulnificus in shellfish would be beneficial in reducing illnesses and deaths caused by this pathogen...
  55. ncbi [Vibrio parahaemolyticus infections and algal intoxications as emergent public health problems in Chile]
    Cristina Hernandez
    Laboratorio de Bromatologia, Autoridad Sanitaria, Secretaría Regional Ministerial de Salud X Región, Puerto Montt, X Región, Chile
    Rev Med Chil 133:1081-8. 2005
    ..Scientific capacity and laboratories need to be developed to widen the limited knowledge of the biology of Vibrio and toxic algae and the environmental factors that favor their emergence as public health and economic problems in Chile...
  56. doi Comparative susceptibility of turbot, halibut, and cod yolk-sac larvae to challenge with Vibrio spp
    Nina Sandlund
    Institute of Marine Research, PO Box 1870 Nordnes, 5817 Bergen, Norway
    Dis Aquat Organ 89:29-37. 2010
    ..The O2beta strain did not cause an increased mortality to halibut and turbot...
  57. pmc Vibrio vulnificus induces macrophage apoptosis in vitro and in vivo
    Takashige Kashimoto
    Laboratory of Veterinary Public Health, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23 35 1, Towada Aomori 034 8628, Japan
    Infect Immun 71:533-5. 2003
    ..The clinical isolates induced apoptosis in macrophage-like cells in vitro and in macrophages in vivo. This suggests that macrophage apoptosis may be important for the clinical virulence of V. vulnificus...
  58. ncbi Characterization of strains of Vibrio splendidus and V. tapetis isolated from corkwing wrasse Symphodus melops suffering vibriosis
    Sigmund Jensen
    Department of Aquaculture, Institute of Marine Research, PO Box 1870 Nordnes, 5817 Bergen, Norway
    Dis Aquat Organ 53:25-31. 2003
    ..tapetis (previously only known as the brown ring disease agent in clams). Identification of the new wrasse pathogens V. splendidus LP1 and V. tapetis LP2 is facilitated by break points observed in this study...
  59. pmc Global dissemination of Vibrio parahaemolyticus serotype O3:K6 and its serovariants
    G Balakrish Nair
    Enteric Microbiology Unit, Laboratory Sciences Division, ICDDR, B Center for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    Clin Microbiol Rev 20:39-48. 2007
    ..This review traces the genesis, virulence features, molecular characteristics, serotype variants, environmental occurrence, and global spread of this unique clone of V. parahaemolyticus...
  60. pmc Wound infections caused by Vibrio vulnificus and other marine bacteria
    J D Oliver
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA
    Epidemiol Infect 133:383-91. 2005
    ....
  61. pmc Determination of molecular phylogenetics of Vibrio parahaemolyticus strains by multilocus sequence typing
    Narjol González-Escalona
    Department of Food Science, North Carolina State University, Raleigh, North Carolina, USA
    J Bacteriol 190:2831-40. 2008
    ..8:1 by allele and site, respectively. Application of this MLST scheme to more V. parahaemolyticus strains and by different laboratories will facilitate production of a global picture of the epidemiology and evolution of this pathogen...
  62. pmc Cloning and characterization of a periplasmic nuclease of Vibrio vulnificus and its role in preventing uptake of foreign DNA
    S I Wu
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China
    Appl Environ Microbiol 67:82-8. 2001
    ..We also demonstrated that Vvn was not required for the virulence of V. vulnificus mice...
  63. ncbi Alternatives to antibiotics to control bacterial infections: luminescent vibriosis in aquaculture as an example
    Tom Defoirdt
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Trends Biotechnol 25:472-9. 2007
    ..Therefore, to make the aquaculture industry more sustainable, new strategies to control infections are urgently needed...
  64. pmc Identification of Vibrio parahaemolyticus pandemic group-specific DNA sequence by genomic subtraction
    Masatoshi Okura
    Department of Bioscience, Graduate School of Science and Technology, Kobe University, Rokko dai 1 1, Nada Ku, Kobe City, Japan 657 8501
    J Clin Microbiol 43:3533-6. 2005
    ..A subtractive DNA fragment was identified to be a part of a 16-kbp insertion sequence which was present in almost all pandemic strains but not in nonpandemic strains tested...
  65. ncbi Severe watery diarrhoea and bacteraemia caused by Vibrio fluvialis
    Chung Hsu Lai
    Department of Infectious Disease, E Da Hospital I Shou University, Jiau Shu Tsuen, Yan Chau Shiang, Taiwan, ROC
    J Infect 52:e95-8. 2006
    ..The patient was cured with intravenous administration of antibiotics and supportive treatment. To the best of our knowledge, this is the first case of gastroenteritis and bacteraemia caused by V. fluvialis...
  66. ncbi Identification and pathogenicity of Vibrio ponticus affecting cultured Japanese sea bass, Lateolabrax japonicus (Cuvier in Cuvier and Valenciennes)
    Z Y Xie
    LAMB, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, Guangzhou, P R China
    Lett Appl Microbiol 45:62-7. 2007
    ..To rapidly determine the causative agent of mass death in Lateolabrax japonicus in Zhelin Bay of Guangdong Province in China in April 2004...
  67. pmc Induction of interleukin-8 production via nuclear factor-kappaB activation in human intestinal epithelial cells infected with Vibrio vulnificus
    B C Lee
    Department of Pharmacy, College of Pharmacy, Chonnam National University, Gwangju Republic of Korea
    Immunology 115:506-15. 2005
    ..vulnificus infection. Taken together, these results indicate clearly that V. vulnificus infection significantly induces IL-8 production in human intestinal epithelial cells via NF-kappaB activation...
  68. pmc Identification of a protein biomarker unique to the pandemic O3:K6 clone of Vibrio parahaemolyticus
    Tracie L Williams
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740, USA
    J Clin Microbiol 42:1657-65. 2004
    ..parahaemolyticus, it was possible to rationally design specific PCR-based probes and assays that permit the rapid and precise identification of pandemic strains of V. parahaemolyticus...
  69. pmc Identification of two translocon proteins of Vibrio parahaemolyticus type III secretion system 2
    Toshio Kodama
    Department of Bacterial Infections, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Infect Immun 76:4282-9. 2008
    ..These results indicate that VopB2 and VopD2 act as translocon proteins of V. parahaemolyticus T3SS2 and hence have a critical role in the T3SS2-dependent enterotoxicity of this bacterium...
  70. pmc A common virulence plasmid in biotype 2 Vibrio vulnificus and its dissemination aided by a conjugal plasmid
    Chung Te Lee
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70160, Taiwan
    J Bacteriol 190:1638-48. 2008
    ..An investigation of six other biotype 2 strains for the presence of various plasmid markers revealed that they all harbored the virulence plasmid and four of them possessed the conjugal plasmid in addition...
  71. pmc Virulence gene- and pandemic group-specific marker profiling of clinical Vibrio parahaemolyticus isolates
    Carolyn E Meador
    Naval Research Laboratory, Center for Bio Molecular Science and Engineering, 4555 Overlook Avenue SW, Bldg 30, Code 6910, Washington, DC 20375, USA
    J Clin Microbiol 45:1133-9. 2007
    ..e., Kanagawa-negative) clinical isolates. These results highlight the genetic dynamism of V. parahaemolyticus and aid in refining the genetic definition of the pandemic group members...
  72. ncbi Vibrio infection associated with finning injury of the hand
    Chih Hsuan Chang-Chien
    Department of Plastic and Reconstructive Surgery, Chia Yi Christian Hospital, Chiayi, Taiwan
    Injury 38:614-8. 2007
    ..Vibrio spp. are known worldwide for their virulence, quickly causing soft-tissue infection and lethal septicaemia. Vibrio infection following finning injury is rare, but can result in devastating complications in susceptible individuals...
  73. pmc Identification of a Wzy polymerase required for group IV capsular polysaccharide and lipopolysaccharide biosynthesis in Vibrio vulnificus
    Alina Nakhamchik
    Division of Clinical Integrative Biology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, S1 26A, Toronto, Ontario, Canada M4N 3N5
    Infect Immun 75:5550-8. 2007
    ..To our knowledge, this is the first functional demonstration of a Wzy polysaccharide polymerase in V. vulnificus and is the first to show a link between LPS and CPS biosynthesis...
  74. ncbi Synergistic antimicrobial effect of cefotaxime and minocycline on proinflammatory cytokine levels in a murine model of Vibrio vulnificus infection
    Shyh Ren Chiang
    Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan
    J Microbiol Immunol Infect 40:123-33. 2007
    ..This study aimed to evaluate the antimicrobial effect of cefotaxime and minocycline on proinflammatory cytokine levels in a murine model of V. vulnificus infection...
  75. ncbi Vibrio harveyi: a significant pathogen of marine vertebrates and invertebrates
    B Austin
    School of Life Sciences, John Muir Building, Heriot Watt University, Riccarton, Edinburgh, UK
    Lett Appl Microbiol 43:119-24. 2006
    ....
  76. pmc Variability of properties of Vibrio parahaemolyticus strains isolated from individual patients
    Phuangthip Bhoopong
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai 90112, Thailand
    J Clin Microbiol 45:1544-50. 2007
    ..Finally, the present study did not rule out the possibility that isolates lacking tdh and trh have unknown virulence mechanisms other than the tdh and trh genes...
  77. pmc Arp2/3-independent assembly of actin by Vibrio type III effector VopL
    Amy D B Liverman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:17117-22. 2007
    ..Vibrio VopL is predicted to be a bacterial virulence factor that disrupts actin homeostasis during an enteric infection of the host...
  78. pmc Four genomic islands that mark post-1995 pandemic Vibrio parahaemolyticus isolates
    Catherine C Hurley
    Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
    BMC Genomics 7:104. 2006
    ..In 1996 the first appearance of a pandemic V. parahaemolyticus clone occurred, a new O3:K6 serotype strain that has now been identified worldwide as a major cause of seafood-borne gastroenteritis...
  79. ncbi Vibrio parahaemolyticus in shellfish and clinical samples during two large epidemics of diarrhoea in southern Chile
    Loreto Fuenzalida
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Environ Microbiol 8:675-83. 2006
    ..In summary, the causative agent during epidemics was only a minor component of a small but diverse population of V. parahaemolyticus in shellfish...
  80. ncbi Serological and molecular characteristics of Vibrio vulnificus biotype 3: evidence for high clonality
    Naiel Bisharat
    Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Microbiology 153:847-56. 2007
    ..vulnificus...
  81. pmc Genetic distinctions among clinical and environmental strains of Vibrio vulnificus
    Maria Chatzidaki-Livanis
    University of Florida, Department of Food Science and Human Nutrition, P O Box 110370, Gainesville, FL 32611, USA
    Appl Environ Microbiol 72:6136-41. 2006
    ..However, this study was not an extensive survey, and more sampling using rep-PCR for sensitive genetic discrimination is needed to determine the virulence potential of environmental reservoirs...
  82. ncbi Detection of total and hemolysin-producing Vibrio parahaemolyticus in shellfish using multiplex PCR amplification of tl, tdh and trh
    A K Bej
    Department of Biology, The University of Alabama at Birmingham, 35294 1170, USA
    J Microbiol Methods 36:215-25. 1999
    ..Compared to conventional microbiological culture methods, this multiplex PCR approach is rapid and reliable for accomplishing a comprehensive detection of V. parahaemolyticus in shellfish...
  83. ncbi New aminoglycoside acetyltransferase gene, aac(3)-Id, in a class 1 integron from a multiresistant strain of Vibrio fluvialis isolated from an infant aged 6 months
    Ashraf M Ahmed
    Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Japan
    J Antimicrob Chemother 53:947-51. 2004
    ..To characterize the molecular basis of antibiotic resistance in a multidrug-resistant clinical isolate of Vibrio fluvialis H-08942...
  84. ncbi Cytotoxicity and enterotoxicity of the thermostable direct hemolysin-deletion mutants of Vibrio parahaemolyticus
    Kwon Sam Park
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Japan
    Microbiol Immunol 48:313-8. 2004
    ..These results indicate that the cytotoxicity and enterotoxicity of TDH-producing V. parahaemolyticus are not explained by TDH alone, and suggest that an unknown virulence factor(s) could be involved in these pathogenic activities...
  85. pmc Assessment of evolution of pandemic Vibrio parahaemolyticus by multilocus sequence typing
    Nandini Roy Chowdhury
    National Institute of Cholera and Enteric Diseases, Calcutta, India
    J Clin Microbiol 42:1280-2. 2004
    ..Our sequence data provide strong molecular support for the clonal origin of pandemic V. parahaemolyticus O3:K6 and suggest that strains within such a clonal group may acquire previously identified serotypes...
  86. pmc Prevalence and serodiversity of the pandemic clone among the clinical strains of Vibrio parahaemolyticus isolated in southern Thailand
    V Laohaprertthisan
    Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90112, Thailand
    Epidemiol Infect 130:395-406. 2003
    ..The results demonstrate prevalence of infection by the pandemic clone in southern Thailand and suggest emergence of various serovariants in this area and their implication in international spread...
  87. ncbi Bacteremic cellulitis caused by non-O1, non-O139 Vibrio cholerae in a patient following hematopoietic stem cell transplantation
    S M Choi
    Bone Marrow Transplant 31:1181-2. 2003
  88. pmc Vibrio alginolyticus cellulitis following coral injury
    T F Patterson
    Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut
    Yale J Biol Med 61:507-12. 1988
    ..In this case report, we discuss the diagnosis and treatment of cellulitis in a patient with a Caribbean coral injury associated with Vibrio alginolyticus cellulitis...
  89. ncbi Characterization by PCR of Vibrio parahaemolyticus isolates collected during the 1997-1998 Chilean outbreak
    José Luis Córdova
    Fundación Ciencia para la Vida, Millennium Institute for Fundamental and Applied Biology, Av Marathón 1943, Nunoa, Santiago, Chile
    Biol Res 35:433-40. 2002
    ..The warm seawater caused by the climatological phenomena "El Niño" perhaps favored the geographic dispersion of the bacterium (bacterial bloom) occurring in Antofagasta that occurred during that time of year...
  90. ncbi Proinflammatory cytokine profile in Vibrio vulnificus septicemic patients' sera
    Sung Heui Shin
    Department of Microbiology, Chosun University Medical School, 501 759, Kwangju, South Korea
    FEMS Immunol Med Microbiol 33:133-8. 2002
    ..vulnificus septicemia like in other endotoxemic shocks. The use of doxycycline as an effective bactericidal agent and as an effective modulator of proinflammatory cytokines is supported...
  91. ncbi Molecular analysis of Vibrio parahaemolyticus isolated from human patients and shellfish during US Pacific north-west outbreaks
    G E Kaufman
    Department of Biology, University of Alabama at Birmingham, 35294 1170, USA
    Lett Appl Microbiol 34:155-61. 2002
    ....
  92. ncbi Chloride secretion induced by thermostable direct haemolysin of Vibrio parahaemolyticus depends on colonic cell maturation
    A Takahashi
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Med Microbiol 50:870-8. 2001
    ..These results suggest that sensitivity to TDH is affected by the stage of cellular differentiation of cultured intestinal epithelial cells...
  93. pmc Identification of a group 1-like capsular polysaccharide operon for Vibrio vulnificus
    A C Wright
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 69:6893-901. 2001
    ..Full virulence in mice required surface expression of CPS and supported the essential role of capsule in the pathogenesis of V. vulnificus...
  94. pmc Duplication of hemolysin genes in a virulent isolate of Vibrio harveyi
    X H Zhang
    Department of Biological Sciences, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, Scotland
    Appl Environ Microbiol 67:3161-7. 2001
    ..Surprisingly, the level of vhh-specific RNA transcript produced by VIB 645 was found to be very low. We conclude that the hemolytic phenotype of VIB 645 is not due to increased expression of one or both copies of the vhh gene...
  95. pmc A filamentous phage associated with recent pandemic Vibrio parahaemolyticus O3:K6 strains
    H Nasu
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Microbiol 38:2156-61. 2000
    ..parahaemolyticus O3:K6 strains. The ORF8 gene can be a useful genetic marker for the identification of the recently widespread O3:K6 strains of V. parahaemolyticus...
  96. ncbi Vibrio parahaemolyticus infections in the United States, 1973-1998
    N A Daniels
    University of California, San Francisco, Department of Medicine, Division of General Internal Medicine, San Francisco, CA 94115, USA
    J Infect Dis 181:1661-6. 2000
    ..The median attack rate among persons who consumed the implicated seafood was 56%. To prevent V. parahaemolyticus infections, persons should avoid consumption of raw or undercooked shellfish and exposure of wounds to seawater...
  97. ncbi Vibrio cholerae O2 as a cause of a skin lesion in a tourist returning from Tunisia
    C Farina
    , Azienda Ospedaliera Ospedali Riuniti di Bergamo, Largo Barozzi 1, 24128 Bergamo, Italy
    J Travel Med 7:92-4. 2000
    ..We describe a case of non O1 Vibrio cholerae infection with cutaneous bullous lesions in a tourist returning from Tunisia...
  98. pmc Pandemic spread of an O3:K6 clone of Vibrio parahaemolyticus and emergence of related strains evidenced by arbitrarily primed PCR and toxRS sequence analyses
    C Matsumoto
    Center for Southeast Asian Studies, Kyoto University, Yoshida, Sakyo ku, Kyoto, Okinawa, Japan
    J Clin Microbiol 38:578-85. 2000
    ..parahaemolyticus and reports a novel toxRS-targeted PCR method that will be useful in epidemiological investigation of the cases associated with the current pandemic spread...
  99. ncbi Clinical, epidemiological, and microbiological features of Vibrio vulnificus biogroup 3 causing outbreaks of wound infection and bacteraemia in Israel. Israel Vibrio Study Group
    N Bisharat
    Infectious Diseases Unit, Ha Emek Medical Center, Afula, Israel
    Lancet 354:1421-4. 1999
    ..In the summer and autumn of 1996 and 1997, an outbreak of invasive V. vulnificus infection occurred in Israel in people who had recently handled fresh, whole fish purchased from artificial fish-ponds...
  100. pmc Development of a loop-mediated isothermal amplification assay for sensitive and rapid detection of Vibrio parahaemolyticus
    Wataru Yamazaki
    Division of Bacteriology, Osaka Prefectural Institute of Public Health, Osaka, Japan
    BMC Microbiol 8:163. 2008
    ..Thus, we developed a novel and highly specific loop-mediated isothermal amplification (LAMP) assay for the sensitive and rapid detection of Vibrio parahaemolyticus...
  101. doi Acute infectious peritonitis caused by Vibrio fluvialis
    Ja Young Lee
    Department of Laboratory Medicine, College of Medicine, Inje University, Busan 614 735, South Korea
    Diagn Microbiol Infect Dis 62:216-8. 2008
    ..We describe a case of V. fluvialis peritonitis after a traffic accident that is, to our knowledge, the 1st report of non-continuous ambulatory peritoneal dialysis-related acute peritonitis caused by this organism...

Research Grants46

  1. Molecular Pathogenesis of Vibrio vulnificus
    PAUL GULIG; Fiscal Year: 2006
    ..These studies will elucidate mechanisms of fulminating, invasive disease caused by V. vulnificus as related to rapid replication, evasion of defenses, and damage to host tissues. ..
  2. Regulated expression of B. burgdorferi virulence genes
    FELIPE CARDENAS CABELLO; Fiscal Year: 2010
    ..burgdorferi. These tools will be used to identify genes that are potentially responsible for this organism's virulence and which could be targets for new vaccines and antibiotics against Lyme disease. ..
  3. GENETIC APPROACHES TO VIRULENCE IN B. BURGDORFERI
    Felipe Cabello; Fiscal Year: 2005
    ..We expect these experiments will permit the extension of the molecular Koch's postulates to the characterization of unique aud specific molecular virulence determinants of B. burgdorferi. ..
  4. MOLECULAR BIOLOGY AND VIRULENCE OF CTX PHAGE
    Matthew Waldor; Fiscal Year: 2007
    ..In addition, they may reveal ways in which changes in phage gene expression or copy number can contribute to the pathogenicity of V. cholerae. ..
  5. Molecular Pathogenesis of Vibrio vulnificus
    PAUL GULIG; Fiscal Year: 2007
    ..These studies will elucidate mechanisms of fulminating, invasive disease caused by V. vulnificus as related to rapid replication, evasion of defenses, and damage to host tissues. ..
  6. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    Karen L Visick; Fiscal Year: 2010
    ....
  7. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    KAREN VISICK; Fiscal Year: 2009
    ..parahaemolyticus and V. vulnificus. Studying this model may also lead to approaches that prevent, reduce or treat such infections. ..
  8. Amino acid prototrophy as a positive selective marker in Francisella
    James Bina; Fiscal Year: 2007
    ..The results of the proposed work will provide much needed genetic tools which will facilitate drug discovery, vaccine development, cell biology experiments, and microbiological experiments with virulent F. tularensis strains. ..
  9. Mucosal immune response to oral cholera vaccine Peru 15
    Firdausi Qadri; Fiscal Year: 2007
    ..cholerae. ..
  10. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    KAREN VISICK; Fiscal Year: 2007
    ..parahaemolyticus and V. vulnificus. Studying this model may also lead to approaches that prevent, reduce or treat such infections. ..
  11. Stringent response and bmp expression in B. burgdorferi
    Felipe Cabello; Fiscal Year: 2007
    ..burgdorferi from a descriptive paradigm to a paradigm framed by mechanistic and causal interpretations. ..
  12. CLINICAL RESEARCH CURRICULM AWARD
    John Morris; Fiscal Year: 2004
    ..Details are provided in the body of this application. ..
  13. REGULATION OF EXPRESSION OF BORRELIA BURGDORFERI BMPC
    Felipe Cabello; Fiscal Year: 2001
    ..burgdorferi 297 grown under different conditions in vitro and in vivo. The latter studies will indicate whether different levels of transcription are secondary to changes in the regulatory and structural DNA sequences of the bmpC gene. ..
  14. MOLECULAR BIOLOGY AND VIRULENCE OF CTX PHAGE
    Matthew Waldor; Fiscal Year: 2002
    ..This work will also have important ramifications for the design of safer live attenuated V. cholerae vaccine strains. ..
  15. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    KAREN VISICK; Fiscal Year: 2004
    ..Identification and characterization of the critical colonization genes will lay the foundation for understanding signal exchange between a prokaryote and a eukaryote during the establishment of a long-term association. ..