vibrio infections

Summary

Summary: Infections with bacteria of the genus VIBRIO.

Top Publications

  1. ncbi Nonfoodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997-2006
    Amy M Dechet
    AIDS Education and Training Center, San Francisco General Hospital, San Francisco, California, USA
    Clin Infect Dis 46:970-6. 2008
  2. ncbi Vibrio tapetis-like strain isolated from introduced Manila clams Ruditapes philippinarum showing symptoms of brown ring disease in Norway
    Christine Paillard
    Institut Universitaire Europeen de la Mer, LEMAR, UMR 6539, Universite de Bretagne Occidentale, 29280 Plouzane, France
    Dis Aquat Organ 81:153-61. 2008
  3. pmc Vibrio parahaemolyticus cell biology and pathogenicity determinants
    Christopher A Broberg
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas TX 75390 9148, USA
    Microbes Infect 13:992-1001. 2011
  4. pmc Global dissemination of Vibrio parahaemolyticus serotype O3:K6 and its serovariants
    G Balakrish Nair
    Enteric Microbiology Unit, Laboratory Sciences Division, ICDDR, B Center for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    Clin Microbiol Rev 20:39-48. 2007
  5. ncbi Vibrio parahaemolyticus infections in the United States, 1973-1998
    N A Daniels
    University of California, San Francisco, Department of Medicine, Division of General Internal Medicine, San Francisco, CA 94115, USA
    J Infect Dis 181:1661-6. 2000
  6. pmc Functional characterization of two type III secretion systems of Vibrio parahaemolyticus
    Kwon Sam Park
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, 565 0871, Japan
    Infect Immun 72:6659-65. 2004
  7. pmc Characterization of pathogenic Vibrio parahaemolyticus isolates from clinical sources in Spain and comparison with Asian and North American pandemic isolates
    Jaime Martinez-Urtaza
    Instituto de Acuicultura, Universidad de Santiago de Compostela, Campus Universitario Sur, Santiago de Compostela, Spain
    J Clin Microbiol 42:4672-8. 2004
  8. ncbi Increasing rates of vibriosis in the United States, 1996-2010: review of surveillance data from 2 systems
    Anna Newton
    Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA
    Clin Infect Dis 54:S391-5. 2012
  9. pmc Pandemic serovars (O3:K6 and O4:K68) of Vibrio parahaemolyticus associated with diarrhea in Mozambique: spread of the pandemic into the African continent
    M Ansaruzzaman
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Clin Microbiol 43:2559-62. 2005
  10. pmc Epidemiology of Vibrio parahaemolyticus outbreaks, southern Chile
    Erika Harth
    Universidad de Chile, Santiago, Chile
    Emerg Infect Dis 15:163-8. 2009

Research Grants

Detail Information

Publications250 found, 100 shown here

  1. ncbi Nonfoodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997-2006
    Amy M Dechet
    AIDS Education and Training Center, San Francisco General Hospital, San Francisco, California, USA
    Clin Infect Dis 46:970-6. 2008
    ..Like foodborne Vibrio infections, nonfoodborne Vibrio infections (NFVI) also result in serious illness, but awareness of these infections is ..
  2. ncbi Vibrio tapetis-like strain isolated from introduced Manila clams Ruditapes philippinarum showing symptoms of brown ring disease in Norway
    Christine Paillard
    Institut Universitaire Europeen de la Mer, LEMAR, UMR 6539, Universite de Bretagne Occidentale, 29280 Plouzane, France
    Dis Aquat Organ 81:153-61. 2008
    ..8% similarity) and the Cpn60 encoding gene had 22 substitutions out of 548 nt compared (96% similarity). This is the first finding of BRD and the first isolation of a V. tapetis-like bacterial strain from a bivalve in Norway...
  3. pmc Vibrio parahaemolyticus cell biology and pathogenicity determinants
    Christopher A Broberg
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas TX 75390 9148, USA
    Microbes Infect 13:992-1001. 2011
    ..The following describes the known pathogenicity determinants while establishing the need for continued research...
  4. pmc Global dissemination of Vibrio parahaemolyticus serotype O3:K6 and its serovariants
    G Balakrish Nair
    Enteric Microbiology Unit, Laboratory Sciences Division, ICDDR, B Center for Health and Population Research, Mohakhali, Dhaka 1212, Bangladesh
    Clin Microbiol Rev 20:39-48. 2007
    ..This review traces the genesis, virulence features, molecular characteristics, serotype variants, environmental occurrence, and global spread of this unique clone of V. parahaemolyticus...
  5. ncbi Vibrio parahaemolyticus infections in the United States, 1973-1998
    N A Daniels
    University of California, San Francisco, Department of Medicine, Division of General Internal Medicine, San Francisco, CA 94115, USA
    J Infect Dis 181:1661-6. 2000
    ..The median attack rate among persons who consumed the implicated seafood was 56%. To prevent V. parahaemolyticus infections, persons should avoid consumption of raw or undercooked shellfish and exposure of wounds to seawater...
  6. pmc Functional characterization of two type III secretion systems of Vibrio parahaemolyticus
    Kwon Sam Park
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, 565 0871, Japan
    Infect Immun 72:6659-65. 2004
    ....
  7. pmc Characterization of pathogenic Vibrio parahaemolyticus isolates from clinical sources in Spain and comparison with Asian and North American pandemic isolates
    Jaime Martinez-Urtaza
    Instituto de Acuicultura, Universidad de Santiago de Compostela, Campus Universitario Sur, Santiago de Compostela, Spain
    J Clin Microbiol 42:4672-8. 2004
    ..The results of this study suggest that a unique and specific clone could be related to the V. parahaemolyticus infections in Europe...
  8. ncbi Increasing rates of vibriosis in the United States, 1996-2010: review of surveillance data from 2 systems
    Anna Newton
    Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA
    Clin Infect Dis 54:S391-5. 2012
    ..COVIS conducts passive surveillance and FoodNet conducts active surveillance for laboratory-confirmed Vibrio infections.
  9. pmc Pandemic serovars (O3:K6 and O4:K68) of Vibrio parahaemolyticus associated with diarrhea in Mozambique: spread of the pandemic into the African continent
    M Ansaruzzaman
    Laboratory Sciences Division, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Clin Microbiol 43:2559-62. 2005
    ..This is the first report of the isolation of pandemic strains of V. parahaemolyticus in sub-Saharan Africa and clearly indicates that the pandemic of V. parahaemolyticus has spread into the African continent...
  10. pmc Epidemiology of Vibrio parahaemolyticus outbreaks, southern Chile
    Erika Harth
    Universidad de Chile, Santiago, Chile
    Emerg Infect Dis 15:163-8. 2009
    ..parahaemolyticus groups comprising the diverse and shifting bacterial population in shellfish in this region...
  11. pmc Contribution of Vibrio parahaemolyticus virulence factors to cytotoxicity, enterotoxicity, and lethality in mice
    Hirotaka Hiyoshi
    Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Infect Immun 78:1772-80. 2010
    ..Our findings provide new indications that these virulence factors contribute to and orchestrate each distinct aspect of the pathogenicity of V. parahaemolyticus...
  12. pmc Pandemic spread of an O3:K6 clone of Vibrio parahaemolyticus and emergence of related strains evidenced by arbitrarily primed PCR and toxRS sequence analyses
    C Matsumoto
    Center for Southeast Asian Studies, Kyoto University, Yoshida, Sakyo ku, Kyoto, Okinawa, Japan
    J Clin Microbiol 38:578-85. 2000
    ..parahaemolyticus and reports a novel toxRS-targeted PCR method that will be useful in epidemiological investigation of the cases associated with the current pandemic spread...
  13. ncbi Characteristics of a pandemic clone of O3 : K6 and O4 : K68 Vibrio parahaemolyticus isolated in Beira, Mozambique
    M Ansaruzzaman
    ICDDR, B International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka 1212, Bangladesh
    J Med Microbiol 57:1502-7. 2008
    ..The O3 : K58 (n=8), O4 : K13 (n=6), O3 : KUT (n=1) and O8 : K41 (n=1) strains showed unique characteristics different from the pandemic clone...
  14. pmc Determination of molecular phylogenetics of Vibrio parahaemolyticus strains by multilocus sequence typing
    Narjol González-Escalona
    Department of Food Science, North Carolina State University, Raleigh, North Carolina, USA
    J Bacteriol 190:2831-40. 2008
    ..8:1 by allele and site, respectively. Application of this MLST scheme to more V. parahaemolyticus strains and by different laboratories will facilitate production of a global picture of the epidemiology and evolution of this pathogen...
  15. pmc Pandemic Vibrio parahaemolyticus O3:K6 spread, France
    Marie Laure Quilici
    Emerg Infect Dis 11:1148-9. 2005
  16. pmc Four genomic islands that mark post-1995 pandemic Vibrio parahaemolyticus isolates
    Catherine C Hurley
    Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
    BMC Genomics 7:104. 2006
    ..In 1996 the first appearance of a pandemic V. parahaemolyticus clone occurred, a new O3:K6 serotype strain that has now been identified worldwide as a major cause of seafood-borne gastroenteritis...
  17. pmc Association of pandemic Vibrio parahaemolyticus O3:K6 present in the coastal environment of Northwest Mexico with cases of recurrent diarrhea between 2004 and 2010
    Jorge Velazquez-Roman
    Seccion de Posgrado, Escuela Superior de Medicina IPN, Mexico City, Mexico
    Appl Environ Microbiol 78:1794-803. 2012
    ....
  18. ncbi Pathogenic Vibrio harveyi, in contrast to non-pathogenic strains, intervenes with the p38 MAPK pathway to avoid an abalone haemocyte immune response
    Marie Agnès Travers
    France Haliotis, Kerazan, Lilia, 29880 Plouguerneau, France
    J Cell Biochem 106:152-60. 2009
    ..Taken together, our results suggest that p38 MAPK modulation may be one of the ways of virulent V. harveyi to attack its host and escape abalone immune response...
  19. pmc Whole transcriptome profiling of successful immune response to Vibrio infections in the oyster Crassostrea gigas by digital gene expression analysis
    Julien de Lorgeril
    Institut Francais de Recherche pour l Exploitation de la Mer, Centre National de la Recherche Scientifique, Montpellier, France
    PLoS ONE 6:e23142. 2011
    ..gigas immune responsiveness to circumvent Vibrio infections, we have developed the first deep sequencing study of the transcriptome of hemocytes, the immunocompetent ..
  20. pmc Development of two animal models to study the function of Vibrio parahaemolyticus type III secretion systems
    Pablo Piñeyro
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 78:4551-9. 2010
    ..The two models introduced herein produce robust results and provide a means to determine how different T3SS1 and T3SS2 effector proteins contribute to pathogenesis of V. parahaemolyticus infection...
  21. ncbi Outbreak of Vibrio parahaemolyticus gastroenteritis associated with Alaskan oysters
    Joseph B McLaughlin
    Division of Public Health, Alaska Department of Health and Social Services, Anchorage, AK 99503, USA
    N Engl J Med 353:1463-70. 2005
    ..We describe a recognized outbreak of V. parahaemolyticus infection associated with the consumption of seafood from Alaska...
  22. pmc Genotypic analyses of Vibrio parahaemolyticus and development of a pandemic group-specific multiplex PCR assay
    Masatoshi Okura
    Department of Bioscience, Graduate School of Science and Technology, Kobe University, Rokko dai 1 1, Nada Ku, Kobe, 657 8501, Japan
    J Clin Microbiol 41:4676-82. 2003
    ..The assay successfully distinguished pandemic group strains from other V. parahaemolyticus strains by yielding two distinct PCR products for tdh (263 bp) and the toxRS/new sequence (651 bp)...
  23. ncbi Vibrio parahaemolyticus isolates from southeastern Chinese coast are genetically diverse with circulation of clonal complex 3 strains since 2002
    Ying Yu
    Zhejiang University Institute of Preventive Veterinary Medicine and Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Hangzhou, China
    Foodborne Pathog Dis 8:1169-76. 2011
    ....
  24. ncbi Epidemiology, pathogenesis, and prevention of foodborne Vibrio parahaemolyticus infections
    P S Marie Yeung
    Department of Food Science, Cornell University, Ithaca, New York 14853, USA
    Foodborne Pathog Dis 1:74-88. 2004
    ..This review summarizes epidemiological findings, discusses recognized and putative V. parahaemolyticus virulence factors and pathogenicity mechanisms, and describes strategies for preventing V. parahaemolyticus infections...
  25. pmc Dynamics of clinical and environmental Vibrio parahaemolyticus strains during seafood-related summer diarrhea outbreaks in southern Chile
    Katherine García
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, El Libano 5524, Macul, Santiago 6903625, Chile
    Appl Environ Microbiol 75:7482-7. 2009
    ..parahaemolyticus pathogenic strains become evident...
  26. ncbi Cytotoxicity and enterotoxicity of the thermostable direct hemolysin-deletion mutants of Vibrio parahaemolyticus
    Kwon Sam Park
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Japan
    Microbiol Immunol 48:313-8. 2004
    ..These results indicate that the cytotoxicity and enterotoxicity of TDH-producing V. parahaemolyticus are not explained by TDH alone, and suggest that an unknown virulence factor(s) could be involved in these pathogenic activities...
  27. pmc Effect on human cells of environmental Vibrio parahaemolyticus strains carrying type III secretion system 2
    Greta Caburlotto
    Dipartimento di Patologia, Sezione di Microbiologia, Universita di Verona, Strada Le Grazie 8, Verona, Italy
    Infect Immun 78:3280-7. 2010
    ..On the basis of data presented here, environmental V. parahaemolyticus strains should be included in coastal water surveillance plans, as they may represent a risk for human health...
  28. ncbi Vibrio anguillarum as a fish pathogen: virulence factors, diagnosis and prevention
    I Frans
    Laboratory for Process Microbial Ecology and Bioinspirational Management, Consortium for Industrial Microbiology and Biotechnology, Department of Microbial and Molecular Systems, K U Leuven Association, Lessius Mechelen, Sint Katelijne Waver, Belgium
    J Fish Dis 34:643-61. 2011
    ..This review summarizes the current state of knowledge pertaining to V. anguillarum, focusing on pathogenesis, known virulence factors, diagnosis, prevention and treatment...
  29. pmc Presence of genes for type III secretion system 2 in Vibrio mimicus strains
    Natsumi Okada
    Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    BMC Microbiol 10:302. 2010
    ..cholerae non-O1/non-O139 serogroup strains. However, whether T3SS2-related genes are present in other Vibrio species remains unclear...
  30. pmc Prevalence of the pandemic genotype of Vibrio parahaemolyticus in Dhaka, Bangladesh, and significance of its distribution across different serotypes
    N A Bhuiyan
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1212, Bangladesh
    J Clin Microbiol 40:284-6. 2002
    ..A marker (open reading frame ORF8) for a filamentous phage previously thought to correspond to the pandemic genotype was found to have a poor correlation with the pandemic genotype...
  31. pmc Molecular, serological, and virulence characteristics of Vibrio parahaemolyticus isolated from environmental, food, and clinical sources in North America and Asia
    Angelo DePaola
    Gulf Coast Seafood Laboratory, U S Food and Drug Administration, Dauphin Island, AL 36528, USA
    Appl Environ Microbiol 69:3999-4005. 2003
    ..The fact that certain serotypes and ribotypes contained both clinical and environmental isolates while many others contained only environmental isolates implies that certain serotypes or ribotypes are more relevant for human disease...
  32. ncbi Vibriosis vaccines based on various sero-subgroups of Vibrio anguillarum O2 induce specific protection in Atlantic cod (Gadus morhua L.) juveniles
    Helene Mikkelsen
    NOFIMA Marin, PO Box 6122, N 9291 Tromsø, Norway
    Fish Shellfish Immunol 30:330-9. 2011
    ..However, in groups vaccinated against V. anguillarum sero-subgroups O2b or O2, IL-12p40 and IFNγ gene expression were slightly increased 3 and 55 days post vaccination, respectively...
  33. pmc Vibrio vulnificus rtxA1 gene recombination generates toxin variants with altered potency during intestinal infection
    Jayme S Kwak
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 108:1645-50. 2011
    ..This finding would imply further that in the future on-going genetic variation of the MARTX(Vv) toxins could result in the emergence of novel strains with altered virulence in humans...
  34. ncbi The major outer membrane protein OmpU of Vibrio splendidus contributes to host antimicrobial peptide resistance and is required for virulence in the oyster Crassostrea gigas
    Marylise Duperthuy
    CNRS, UMR 5119, Laboratoire Ecosystèmes Lagunaires, Universite Montpellier 2, 34095 Montpellier, France
    Environ Microbiol 12:951-63. 2010
    ..splendidus. Contributing to AMP resistance, conferring adhesive properties to V. splendidus, and being essential for in vivo fitness, the OmpU porin appears as an essential effector of the C. gigas/V. splendidus interaction...
  35. ncbi Emergence and serovar transition of Vibrio parahaemolyticus pandemic strains isolated during a diarrhea outbreak in Vietnam between 1997 and 1999
    Ashrafuzzaman Chowdhury
    Graduate School of Medicine, Kyoto University, Japan
    Microbiol Immunol 48:319-27. 2004
    ..It was clear that a transition of major serovars occurred among the pandemic strains represented by the emergence of O3: K6 in 1997, O4: K68 in 1998, and O1: K25 in 1998 and 1999...
  36. pmc Characterization and pathogenic significance of Vibrio vulnificus antigens preferentially expressed in septicemic patients
    Young Ran Kim
    National Research Laboratory of Molecular Microbial Pathogenesis, Institute of Vibrio Infection, Genome Research Center for Enteropathogenic Bacteria, Chonnam National University Medical School, 5 Hak dong, Dong Ku, Kwangju 501 746, South Korea
    Infect Immun 71:5461-71. 2003
    ..The successful identification of ive genes responsible for the in vivo bacterial virulence, as done in the present study, demonstrates the usefulness of IVIAT for the detection of new virulence genes...
  37. pmc Genetic variation in the Vibrio vulnificus group 1 capsular polysaccharide operon
    Maria Chatzidaki-Livanis
    University of Florida, Department of Food Science and Human Nutrition, P O Box 110370, Gainesville, FL 32611, USA
    J Bacteriol 188:1987-98. 2006
    ..vulnificus. Repetitive-element-mediated deletion mutations were highly conserved within the species and are likely to promote survival in estuarine environments...
  38. pmc Assessment of evolution of pandemic Vibrio parahaemolyticus by multilocus sequence typing
    Nandini Roy Chowdhury
    National Institute of Cholera and Enteric Diseases, Calcutta, India
    J Clin Microbiol 42:1280-2. 2004
    ..Our sequence data provide strong molecular support for the clonal origin of pandemic V. parahaemolyticus O3:K6 and suggest that strains within such a clonal group may acquire previously identified serotypes...
  39. ncbi Outbreak of gastroenteritis caused by the pandemic Vibrio parahaemolyticus O3:K6 in Mexico
    Hector Cabanillas-Beltrán
    Instituto Tecnológico de Tepic, Nayarit, Mexico
    FEMS Microbiol Lett 265:76-80. 2006
    ..A representative strain belonged to the O3:K6 serogroup. This is the first outbreak of gastroenteritis caused by the pandemic strains of O3:K6 V. parahaemolyticus in México...
  40. pmc Biochemical, serological, and virulence characterization of clinical and oyster Vibrio parahaemolyticus isolates
    Jessica L Jones
    FDA, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, Alaska, USA
    J Clin Microbiol 50:2343-52. 2012
    ..Our findings raise concerns about the reliability of the tdh, trh, and T3SS genes as virulence markers and highlight the need for more-detailed pathogenicity investigations of V. parahaemolyticus...
  41. ncbi Close proximity of the tdh, trh and ure genes on the chromosome of Vibrio parahaemolyticus
    T Iida
    Department of Bacterial Infections, Osaka University, Japan
    Microbiology 144:2517-23. 1998
    ..5 kb. These results reveal a close proximity of the tdh, trh and ure genes on the chromosome of pathogenic V. parahaemolyticus strains...
  42. ncbi Cholera and other types of vibriosis: a story of human pandemics and oysters on the half shell
    J Glenn Morris
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, and Baltimore Veterans Affairs Medical Center, 21201, USA
    Clin Infect Dis 37:272-80. 2003
    ..vulnificus) septicemia in persons who have liver disease or are immunocompromised...
  43. pmc Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis
    Dara L Burdette
    Department of Molecular Biology, University of Texas South Western Medical Center, Dallas, TX 75390, USA
    Mol Microbiol 73:639-49. 2009
    ..parahaemolyticus during infection. These data provide important insights into the mechanism used by V. parahaemolyticus to cause disease...
  44. ncbi Detection of total and hemolysin-producing Vibrio parahaemolyticus in shellfish using multiplex PCR amplification of tl, tdh and trh
    A K Bej
    Department of Biology, The University of Alabama at Birmingham, 35294 1170, USA
    J Microbiol Methods 36:215-25. 1999
    ..Compared to conventional microbiological culture methods, this multiplex PCR approach is rapid and reliable for accomplishing a comprehensive detection of V. parahaemolyticus in shellfish...
  45. pmc Biodiversity of vibrios
    Fabiano L Thompson
    Laboratory of Microbiology, Ghent University, K L Ledeganckstraat 35, Ghent 9000, Belgium
    Microbiol Mol Biol Rev 68:403-31, table of contents. 2004
    ..g., microarrays will facilitate the investigation of the gene repertoire at the species level. Based on such new genomic information, the taxonomy and the species concept for vibrios will be reviewed in the next years...
  46. ncbi Differential expression and biological activity of two piscidin paralogues and a novel splice variant in Atlantic cod (Gadus morhua L.)
    Jareeporn Ruangsri
    Faculty of Biosciences and Aquaculture, University of Nordland, Mørkved, 8049 Bodø, Norway
    Fish Shellfish Immunol 32:396-406. 2012
    ..Moreover, the two pis paralogues have undergone structural diversification and it is likely that they play multifunctional roles in Atlantic cod...
  47. pmc Serologic and molecular characterization of Vibrio parahaemolyticus strains isolated from seawater and fish products of the Gulf of Mexico
    María Eugenia Cabrera-García
    Department of Microbiology of the National School of Biological Sciences, Instituto Politecnico Nacional, Mexico City, Mexico
    Appl Environ Microbiol 70:6401-6. 2004
    ..The most frequent serogroup was serogroup O3. This is the first report of the presence of KP-positive tdh-positive environmental V. parahaemolyticus strains in Mexico...
  48. ncbi Transferable plasmid-mediated quinolone resistance in association with extended-spectrum β-lactamases and fluoroquinolone-acetylating aminoglycoside-6'-N-acetyltransferase in clinical isolates of Vibrio fluvialis
    Goutam Chowdhury
    National Institute of Cholera and Enteric Diseases, P 33, CIT Road, Scheme XM, Beliaghata, Kolkata 700 010, West Bengal, India
    Int J Antimicrob Agents 38:169-73. 2011
    ..qnrA1 along with aac(6')-Ib-cr and bla(CTX-M-3) genes on a mobile plasmid may spread to other bacterial species that are under the selective pressure of fluoroquinolones and β-lactam antimicrobials in this region...
  49. ncbi Clinical manifestation and prognostic factors of non-cholerae Vibrio infections
    C C Hou
    Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan
    Eur J Clin Microbiol Infect Dis 30:819-24. 2011
    ..This epidemiological study helps physicians to better understand the clinical characteristics of infections caused by different non-cholerae Vibrio species...
  50. ncbi Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh, GPOBox 128, Dhaka 1000, Bangladesh
    J Infect Dis 187:1085-96. 2003
    ..Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting...
  51. pmc PCR detection of a newly emerged pandemic Vibrio parahaemolyticus O3:K6 pathogen in pure cultures and seeded waters from the Gulf of Mexico
    Michael L Myers
    Department of Biology, The University of Alabama at Birmingham, 35294 1170, USA
    Appl Environ Microbiol 69:2194-200. 2003
    ..parahaemolyticus O3:K6 strain in coastal, marine, and ship ballast waters. Early detection of V. parahaemolyticus O3:K6 will help increase seafood safety and decrease the risk of infectious outbreaks caused by this pathogen...
  52. ncbi Distribution of genes encoding four pathogenicity islands (VPaIs), T6SS, biofilm, and type I pilus in food and clinical strains of Vibrio parahaemolyticus in China
    Guoxiang Chao
    Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China
    Foodborne Pathog Dis 7:649-58. 2010
    ..VPaI-6 and biofilm-associated genes were harbored by almost all the strains, irrespective of their pandemic, pathogenic, or nonpathogenic traits...
  53. pmc Isolation and characterization of a Vibrio vulnificus mutant deficient in both extracellular metalloprotease and cytolysin
    J J Fan
    Department of Microbiology and Immunology, College of Medicine, National Cheng-Kung University, Tainan 701, Taiwan, Republic of China
    Infect Immun 69:5943-8. 2001
    ..The cytolysin, but not the protease, seemed to be important for causing damage in the alimentary tract of the mice...
  54. pmc Population structures of two genotypes of Vibrio vulnificus in oysters (Crassostrea virginica) and seawater
    Elizabeth Warner
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Appl Environ Microbiol 74:80-5. 2008
    ..Levels of the two genotypes as well as seasonal dynamics within both oyster tissue and the surrounding waters may aid in identifying risk factors associated with human infection...
  55. ncbi Survival of Vibrio vulnificus in whole blood from patients with chronic liver diseases: association with phagocytosis by neutrophils and serum ferritin levels
    L I Hor
    Department of Microbiology, Department of Internal Medicine, National Cheng Kung Univesity, Tainan, Taiwan
    J Infect Dis 179:275-8. 1999
    ..198; P<.05) and phagocytosis by neutrophils (r=-.204; P<.05). Among these parameters, low phagocytosis activity (P<.01) and high ferritin level (P<.01) in the blood were the independent predictors...
  56. ncbi An inhibitor of bacterial quorum sensing reduces mortalities caused by Vibriosis in rainbow trout (Oncorhynchus mykiss, Walbaum)
    Maria Rasch
    Danish Institute for Fisheries Research, Department of Seafood Research, Søltofts Plads, c o Technical University of Denmark, Lyngby, Denmark
    Syst Appl Microbiol 27:350-9. 2004
    ..However, they also underline the need for development of novel, less toxic QSI compounds and the need for understanding the exact mechanism(s) of action...
  57. pmc Molecular analysis of the emergence of pandemic Vibrio parahaemolyticus
    E Fidelma Boyd
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    BMC Microbiol 8:110. 2008
    ..This new highly virulent strain is now globally disseminated...
  58. pmc Multiple-locus variable-number tandem-repeat analysis for clonal identification of Vibrio parahaemolyticus isolates by using capillary electrophoresis
    Erika Harth-Chu
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre of Infection Research, Braunschweig, Germany
    Appl Environ Microbiol 75:4079-88. 2009
    ..The developed approach enables rapid and high-resolution analysis of V. parahaemolyticus with pandemic potential and provides a new surveillance tool for food-borne pathogens...
  59. pmc Role of iron in human serum resistance of the clinical and environmental Vibrio vulnificus genotypes
    Ryan W Bogard
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Appl Environ Microbiol 73:7501-5. 2007
    ..This suggests that the nutrient/osmotic environment may influence the survival of V. vulnificus following entry into the human body, leading to selection of the C genotype over the E genotype...
  60. ncbi RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis
    Horng Ren Lo
    Institute of Basic Medical Sciences, Taiwan, Republic of China
    J Infect Dis 203:1866-74. 2011
    ..These findings suggest that the RTX of V. vulnificus is required for bacterial survival during infection by protecting the organism from phagocytosis...
  61. ncbi The cytotoxin-hemolysin genes of human and eel pathogenic Vibrio vulnificus strains: comparison of nucleotide sequences and application to the genetic grouping
    Mitsutoshi Senoh
    Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Japan
    Microbiol Immunol 49:513-9. 2005
    ..These findings may lead to development of a novel genetic grouping system related to the virulence potential or to the host range...
  62. ncbi Phospholipase A as a potent virulence factor of Vibrio vulnificus
    Bon Sun Koo
    Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561 756, Korea
    Int J Mol Med 20:913-8. 2007
    ..These results indicate that PLA activity is important in V. vulnificus-induced cytotoxicity and lethality, suggesting a crucial role for PLA in the pathogenesis of V. vulnificus infection...
  63. pmc Evaluation of typing of vibrio parahaemolyticus by three PCR methods using specific primers
    H C Wong
    Department of Microbiology, Soochow University, Taipei, Taiwan, Republic of China
    J Clin Microbiol 39:4233-40. 2001
    ..REP-PCR is preferable to ERIC-PCR because of the greater reproducibility of its fingerprints, while RS-PCR may be a practical method because it generates fewer amplification bands and patterns than the alternatives...
  64. ncbi O3:K6 serotype of Vibrio parahaemolyticus identical to the global pandemic clone associated with diarrhea in Peru
    Ana I Gil
    Instituto de Investigacion Nutricional, Av La Molina 1885, Lima 12, Peru, AP 18 091, Lima 18, Peru
    Int J Infect Dis 11:324-8. 2007
    ..To determine if the Vibrio parahaemolyticus O3:K6 global pandemic clone has spread into Peru...
  65. pmc Vibrio parahaemolyticus diarrhea, Chile, 1998 and 2004
    Narjol González-Escalona
    Institute of Nutrition and Food Technology, University of Chile, El Libano 5524, Macul, Santiago 690 3625, Chile
    Emerg Infect Dis 11:129-31. 2005
    ....
  66. ncbi Regulation of Vibrio vulnificus virulence by the LuxS quorum-sensing system
    Soo Young Kim
    National Research Laboratory of Molecular Microbial Pathogenesis, Kwangju, South Korea
    Mol Microbiol 48:1647-64. 2003
    ..Taken together, the V. vulnificus LuxS quorum-sensing system seems to play an important role in co-ordinating the expression of virulence factors...
  67. ncbi Characterization of the Vibrio cholerae vexAB and vexCD efflux systems
    James E Bina
    Department of Molecular Science, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Arch Microbiol 186:171-81. 2006
    ..Mutants containing deletion of vexB, vexD, and vexB-vexD were able to efficiently colonize the infant mouse suggesting that these efflux systems were dispensable for V. cholerae growth in the small intestines of infant mice...
  68. ncbi Emergence of Asiatic Vibrio diseases in South America in phase with El Niño
    Jaime Martinez-Urtaza
    Instituto de Acuicultura, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Epidemiology 19:829-37. 2008
    ..A new Vibrio epidemic arose in 1997 in South America (northern Chile) when the pandemic clone of Vibrio parahaemolyticus was for the fist time detected outside of Asia. These 2 cases were concurrent with 2 episodes of El Niño...
  69. pmc Environmental investigations of Vibrio parahaemolyticus in oysters after outbreaks in Washington, Texas, and New York (1997 and 1998)
    A DePaola
    Gulf Coast Seafood Laboratory, Food and Drug Administration, Dauphin Island, Alabama 36528, USA
    Appl Environ Microbiol 66:4649-54. 2000
    ..Based on our data, findings of more than 10,000 g(-1) total V. parahaemolyticus or >10 g(-1) tdh- and/or trh-positive V. parahaemolyticus in environmental oysters should be considered extraordinary...
  70. pmc Sequence polymorphism of the 16S rRNA gene of Vibrio vulnificus is a possible indicator of strain virulence
    William B Nilsson
    Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, U S Department of Commerce, Seattle, Washington 98112, USA
    J Clin Microbiol 41:442-6. 2003
    ....
  71. ncbi Vibrio vulnificus infection: diagnosis and treatment
    Michael H Bross
    Corpus Christi Family Practice Residency Program, Corpus Christi, Texas 78405, USA
    Am Fam Physician 76:539-44. 2007
    ..Physician awareness of risk factors for V. vulnificus infection combined with prompt diagnosis and treatment can significantly improve patient outcomes. (Am Fam Physic..
  72. pmc Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis
    Dara L Burdette
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:12497-502. 2008
    ..Our studies reveal an infection paradigm whereby an extracellular pathogen uses its type III secretion system to cause at least three parallel events that eventually result in the proinflammatory death of an infected host cell...
  73. ncbi A relationship between antimicrobial peptide gene expression and capacity of a selected shrimp line to survive a Vibrio infection
    Julien de Lorgeril
    IFREMER, CNRS, Universite de Montpellier II, UMR 5119 Ecosystèmes Lagunaires, Place Eugene Bataillon, CC80, 34095 Montpellier Cedex 5, France
    Mol Immunol 45:3438-45. 2008
    ....
  74. ncbi RtxA1-induced expression of the small GTPase Rac2 plays a key role in the pathogenicity of Vibrio vulnificus
    Kyoung Jin Chung
    School of Dentistry, Dental Science Research Institute, The 2nd Stage of Brain Korea 21 for the Dental School, Chonnam National University, Republic of Korea
    J Infect Dis 201:97-105. 2010
    ..vulnificus mutant was unable to induce ROS generation within the intestine and failed to cause death. These findings strongly suggest that RtxA1-induced Rac2 expression is a critical step underlying the pathogenicity of V. vulnificus...
  75. pmc Identification of an iron-regulated hemin-binding outer membrane protein, HupO, in Vibrio fluvialis: effects on hemolytic activity and the oxidative stress response
    Sun Hee Ahn
    Department of Biotechnology and Bioengineering, Pukyong National University, Busan 608 737, Republic of Korea
    Infect Immun 73:722-9. 2005
    ..fluvialis through stimulation of hemolysin production and resistance to oxidative stress. In experimentally infected mice, the 50% lethal dose value of the wild-type was lower than that of the mutant, HP1...
  76. pmc Evaluation of genotypic and phenotypic methods to distinguish clinical from environmental Vibrio vulnificus strains
    Eva Sanjuan
    Departamento de Microbiologia y Ecologia, Universidad de Valencia, Avda Dr Moliner 50, 46100 Burjassot, Valencia, Spain
    Appl Environ Microbiol 75:1604-13. 2009
    ..vulnificus, which suggests that new typing methodologies useful for public health have to be developed for this species...
  77. ncbi Necrotising fasciitis and myositis that originated from gastrointestinal bacterial infection: two fatal cases
    Masaki Fujioka
    Departments of Plastic and Reconstructive Surgery, Fukuoka Tokushukai Medical Center, Fukuoka, Japan
    Scand J Plast Reconstr Surg Hand Surg 37:239-42. 2003
    ..The first patient developed necrosis of the legs over 5 days and he died on the 20th day. Vibrio vulnificus was cultured. The second patient developed bullae on his thigh and he died the next day. Streptococcus pyogenes was cultured...
  78. ncbi Variation of extracellular proteases produced by Vibrio vulnificus clinical isolates: genetic diversity of the metalloprotease gene (vvp), and serine protease secretion by vvp-negative strains
    Jiyou Wang
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Microb Pathog 44:494-500. 2008
    ..These findings suggest that, in addition to metalloprotease, the extracellular serine protease may contribute to pathogenicity of V. vulnificus...
  79. ncbi Inactivation of mismatch repair increases the diversity of Vibrio parahaemolyticus
    Tracy H Hazen
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Environ Microbiol 11:1254-66. 2009
    ..This study is the first to report a higher frequency of natural mutators among Vibrio environmental strains and to provide evidence that inactivation of MMR increases the diversity of V. parahaemolyticus...
  80. pmc Population genetics of Vibrio vulnificus: identification of two divisions and a distinct eel-pathogenic clone
    Michaela Gutacker
    Istituto Cantonale di Microbiologia, 6501 Bellinzona, Switzerland
    Appl Environ Microbiol 69:3203-12. 2003
    ..The significance of the two divisions (divisions I and II) still remains to be clarified, and a reevaluation of the definition of the biotypes is also needed...
  81. ncbi Clinical features of Vibrio vulnificus infections in the coastal areas of the Ariake Sea, Japan
    Kouichi Matsumoto
    Ariake Sea Research Project, Saga University, Saga, Japan
    J Infect Chemother 16:272-9. 2010
    ..The prognosis of this disease is poor, because septic shock and necrotizing fasciitis often develop within a few days. Early diagnosis and treatment are needed to improve the prognosis of V. vulnificus infection...
  82. ncbi Identification of Vibrio harveyi as a causative bacterium for a tail rot disease of sea bream Sparus aurata from research hatchery in Malta
    S Haldar
    International Prevention of Epidemics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 58, Rinkuourai Kita, Izumisano, Osaka, Japan
    Microbiol Res 165:639-48. 2010
    ..Although V. harveyi was reported to be an important pathogen for many aquatic organisms, to our knowledge this might be the first report of disease caused by V. harveyi and their systematic study in the sea bream hatchery from Malta...
  83. pmc Homodimerization and binding of specific domains to the target DNA are essential requirements for HlyU to regulate expression of the virulence gene rtxA1, encoding the repeat-in-toxin protein in the human pathogen Vibrio vulnificus
    Moqing Liu
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    J Bacteriol 193:6895-901. 2011
    ..We also determined that HlyU homodimer formation is an essential requirement for binding to the upstream region of the rtxA1 operon and is the key feature in relieving the H-NS repression of rtxA1 transcription...
  84. pmc Identification of the emerging pathogen Vibrio vulnificus biotype 3 by commercially available phenotypic methods
    Raul Colodner
    Clinical Microbiology Laboratory, Ha Emek Medical Center, Afula 18101, Israel
    J Clin Microbiol 42:4137-40. 2004
    ..Data on the phenotypic pattern of V. vulnificus biotype 3 when processed in all five systems as presented here could help clinical laboratories in identifying this new pathogen...
  85. ncbi Characterization of clinical and environmental types of Vibrio vulnificus isolates from Louisiana oysters
    Feifei Han
    Department of Food Science, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA
    Foodborne Pathog Dis 6:1251-8. 2009
    ..vulnificus. The study also highlighted the need to identify unique virulence markers in this organism, which could facilitate future screening of virulent V. vulnificus strains from oysters...
  86. ncbi The growth of Vibrio vulnificus and the habitat of infected patients in Kumamoto
    Yuji Inoue
    Department of Dermatology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biosci Trends 1:134-9. 2007
    ..vulnificus. Therefore, investigating these geographical and meteorological factors can help predict areas with a higher number of V. vulnificus infection outbreaks...
  87. ncbi Epidemiological survey of Vibrio vulnificus infection in Japan between 1999 and 2003
    Yuji Inoue
    Department of Dermatology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    J Dermatol 35:129-39. 2008
    ..1%) suffered from liver cancer. The incidence of V. vulnificus infection was different according to districts. Geographic and climatic factors also contributed to the occurrence of V. vulnificus infection...
  88. ncbi Immunohistochemistry of Atlantic cod larvae Gadus morhua experimentally challenged with Vibrio anguillarum
    Ane Rebecca Engelsen
    Institute of Marine Research, PO Box 1870 Nordnes, 5817 Bergen, Norway
    Dis Aquat Organ 80:13-20. 2008
    ..Only 2 larvae from the low-challenge dose group showed clear signs of histopathology, which occurred in the intestine. It is not possible to draw any conclusions regarding the portal of entry...
  89. pmc Necrotizing fasciitis from Vibrio vulnificus in a patient with undiagnosed hepatitis and cirrhosis
    Kenneth L Muldrew
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Microbiol 45:1058-62. 2007
    ..Significant risk factors for severe disease include preexisting liver disease. We report a case of Vibrio vulnificus necrotizing fasciitis in a patient with previously undiagnosed chronic hepatitis and cirrhosis...
  90. ncbi Mucosal response in African catfish after administration of Vibrio anguillarum O2 antigens via different routes
    Stefaan Vervarcke
    Laboratorium voor Farmacotechnologie en Biofarmacie, Katholieke Universiteit Leuven, Campus Gasthuisberg O N, Herestraat 49, 3000 Leuven, Belgium
    Fish Shellfish Immunol 18:125-33. 2005
    ..The results obtained are a strong indication for mucosal immune response and the two compartmental models for immune response in fish...
  91. ncbi Vibrio infections in Louisiana: twenty-five years of surveillance 1980-2005
    Annu Thomas
    Infectious Disease Epidemiology Section, Louisiana Office of Public Health, USA
    J La State Med Soc 159:205-8, 210-1. 2007
    A total of 1,007 Vibrio infections were reported to the Infectious Disease Epidemiology Department at the Louisiana Office of Public Heath, between 1980 and 2005...
  92. ncbi Lower extremity infections by vibrio vulnificus
    G Mouzopoulos
    Department of Evangelismos Hospital, Athens, Greece
    Chirurgia (Bucur) 103:201-3. 2008
    ..Vibrio vulnificus is a Gram-negative pathogen which is found in seawater and shellfish during warm months and can cause local infections in healthy individuals or septicemia in patients with chronic liver disease...
  93. ncbi [A collective review of Vibrio vulnificus infection in Japan]
    Hirotaka Oishi
    Ariake Sea Research Project, Saga University
    Kansenshogaku Zasshi 80:680-9. 2006
    ..It is also highly recommended that patients with preexisting liver dysfunction avoid raw fish and limit exposure to marine water during the summer...
  94. ncbi Comparative susceptibility of turbot, halibut, and cod yolk-sac larvae to challenge with Vibrio spp
    Nina Sandlund
    Institute of Marine Research, PO Box 1870 Nordnes, 5817 Bergen, Norway
    Dis Aquat Organ 89:29-37. 2010
    ..The O2beta strain did not cause an increased mortality to halibut and turbot...
  95. ncbi Multiplex PCR detection of clinical and environmental strains of Vibrio vulnificus in shellfish
    Gitika Panicker
    Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294 1170, USA
    Can J Microbiol 50:911-22. 2004
    ..The rapid, sensitive, and specific detection of clinically important pathogenic V. vulnificus in shellfish would be beneficial in reducing illnesses and deaths caused by this pathogen...
  96. ncbi [Vibrio parahaemolyticus infections and algal intoxications as emergent public health problems in Chile]
    Cristina Hernandez
    Laboratorio de Bromatologia, Autoridad Sanitaria, Secretaría Regional Ministerial de Salud X Región, Puerto Montt, X Región, Chile
    Rev Med Chil 133:1081-8. 2005
    ..Scientific capacity and laboratories need to be developed to widen the limited knowledge of the biology of Vibrio and toxic algae and the environmental factors that favor their emergence as public health and economic problems in Chile...
  97. pmc Vibrio vulnificus induces macrophage apoptosis in vitro and in vivo
    Takashige Kashimoto
    Laboratory of Veterinary Public Health, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23 35 1, Towada Aomori 034 8628, Japan
    Infect Immun 71:533-5. 2003
    ..The clinical isolates induced apoptosis in macrophage-like cells in vitro and in macrophages in vivo. This suggests that macrophage apoptosis may be important for the clinical virulence of V. vulnificus...
  98. ncbi Characterization of strains of Vibrio splendidus and V. tapetis isolated from corkwing wrasse Symphodus melops suffering vibriosis
    Sigmund Jensen
    Department of Aquaculture, Institute of Marine Research, PO Box 1870 Nordnes, 5817 Bergen, Norway
    Dis Aquat Organ 53:25-31. 2003
    ..tapetis (previously only known as the brown ring disease agent in clams). Identification of the new wrasse pathogens V. splendidus LP1 and V. tapetis LP2 is facilitated by break points observed in this study...
  99. pmc Wound infections caused by Vibrio vulnificus and other marine bacteria
    J D Oliver
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA
    Epidemiol Infect 133:383-91. 2005
    ....
  100. pmc Cloning and characterization of a periplasmic nuclease of Vibrio vulnificus and its role in preventing uptake of foreign DNA
    S I Wu
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China
    Appl Environ Microbiol 67:82-8. 2001
    ..We also demonstrated that Vvn was not required for the virulence of V. vulnificus mice...
  101. ncbi Alternatives to antibiotics to control bacterial infections: luminescent vibriosis in aquaculture as an example
    Tom Defoirdt
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Trends Biotechnol 25:472-9. 2007
    ..Therefore, to make the aquaculture industry more sustainable, new strategies to control infections are urgently needed...

Research Grants6

  1. Stringent response and bmp expression in B. burgdorferi
    Felipe Cabello; Fiscal Year: 2007
    ..burgdorferi from a descriptive paradigm to a paradigm framed by mechanistic and causal interpretations. ..
  2. Regulated expression of B. burgdorferi virulence genes
    FELIPE CARDENAS CABELLO; Fiscal Year: 2010
    ..burgdorferi. These tools will be used to identify genes that are potentially responsible for this organism's virulence and which could be targets for new vaccines and antibiotics against Lyme disease. ..
  3. CLINICAL RESEARCH CURRICULM AWARD
    John Morris; Fiscal Year: 2004
    ..Details are provided in the body of this application. ..
  4. Molecular Pathogenesis of Vibrio vulnificus
    PAUL GULIG; Fiscal Year: 2007
    ..These studies will elucidate mechanisms of fulminating, invasive disease caused by V. vulnificus as related to rapid replication, evasion of defenses, and damage to host tissues. ..
  5. Mucosal immune response to oral cholera vaccine Peru 15
    Firdausi Qadri; Fiscal Year: 2007
    ..cholerae. ..
  6. Amino acid prototrophy as a positive selective marker in Francisella
    James Bina; Fiscal Year: 2008
    ..tularensis strains. [unreadable] [unreadable] [unreadable]..