rickettsia infections

Summary

Summary: Infections by the genus RICKETTSIA.

Top Publications

  1. pmc Rickettsioses as paradigms of new or emerging infectious diseases
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, CNRS UPRESA 6020, Marseille, France
    Clin Microbiol Rev 10:694-719. 1997
  2. ncbi Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States
    Christopher D Paddock
    Division of Viral and Rickettsial Diseases, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 38:805-11. 2004
  3. ncbi Rickettsia felis: from a rare disease in the USA to a common cause of fever in sub-Saharan Africa
    P Parola
    Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD, WHO Collaborative Center for Rickettsioses and Other Arthropod Borne Bacterial Diseases, Faculte de Medecine, Université de Méditerranée, Marseille Cedex 5, France
    Clin Microbiol Infect 17:996-1000. 2011
  4. ncbi Development of quantitative real-time PCR assays to detect Rickettsia typhi and Rickettsia felis, the causative agents of murine typhus and flea-borne spotted fever
    Katherine M Henry
    Rickettsial Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Mol Cell Probes 21:17-23. 2007
  5. ncbi Ecology of rickettsia in South America
    Marcelo B Labruna
    Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Ann N Y Acad Sci 1166:156-66. 2009
  6. pmc Tick-borne rickettsioses around the world: emerging diseases challenging old concepts
    Philippe Parola
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Universite de la Mediterranee, Faculte de Medecine, 13385 Marseille Cedex 5, France
    Clin Microbiol Rev 18:719-56. 2005
  7. ncbi Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study
    C Suttinont
    Department of Medicine, Maharat Nakhon Ratchasima Hospital, Amphur Mueng, Nakhon Ratchasima Province, 30000, Thailand
    Ann Trop Med Parasitol 100:363-70. 2006
  8. ncbi Emerging and re-emerging tick-transmitted rickettsial and ehrlichial infections
    David H Walker
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
    Med Clin North Am 92:1345-61, x. 2008
  9. ncbi Infection and transovarial transmission of rickettsiae in Dermacentor variabilis ticks acquired by artificial feeding
    K R Macaluso
    Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore, Baltimore, MD 21201, USA
    Vector Borne Zoonotic Dis 1:45-53. 2001
  10. ncbi Molecular evidence supports the role of dogs as potential reservoirs for Rickettsia felis
    Sze Fui Hii
    School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia
    Vector Borne Zoonotic Dis 11:1007-12. 2011

Research Grants

Detail Information

Publications231 found, 100 shown here

  1. pmc Rickettsioses as paradigms of new or emerging infectious diseases
    D Raoult
    Unite des Rickettsies, Faculte de Medecine, CNRS UPRESA 6020, Marseille, France
    Clin Microbiol Rev 10:694-719. 1997
    ..We also assess the pathogenic potential of rickettsial strains that to date have been associated only with arthropods, and we discuss diseases of unknown etiology that may be rickettsioses...
  2. ncbi Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States
    Christopher D Paddock
    Division of Viral and Rickettsial Diseases, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 38:805-11. 2004
    ..parkeri rickettsiosis and possibly other novel SFG rickettsioses in the United States...
  3. ncbi Rickettsia felis: from a rare disease in the USA to a common cause of fever in sub-Saharan Africa
    P Parola
    Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD, WHO Collaborative Center for Rickettsioses and Other Arthropod Borne Bacterial Diseases, Faculte de Medecine, Université de Méditerranée, Marseille Cedex 5, France
    Clin Microbiol Infect 17:996-1000. 2011
    ..felis infection. More studies are needed, including the study of other arthropod vectors, but it can be speculated that R. felis infection might be an important neglected agent of fever in sub-Saharan Africa...
  4. ncbi Development of quantitative real-time PCR assays to detect Rickettsia typhi and Rickettsia felis, the causative agents of murine typhus and flea-borne spotted fever
    Katherine M Henry
    Rickettsial Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Mol Cell Probes 21:17-23. 2007
    ..typhi and R. felis nucleic acid in the cat flea, Ctenocephalides felis. These results demonstrate that two sensitive and specific qPCR assays have been successfully developed to detect and enumerate R. typhi and R. felis...
  5. ncbi Ecology of rickettsia in South America
    Marcelo B Labruna
    Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Ann N Y Acad Sci 1166:156-66. 2009
    ..In Brazil, capybaras and opossums are the most probable amplifier hosts for R. rickettsii, among A. cajennense ticks, and small rodents for A. aureolatum...
  6. pmc Tick-borne rickettsioses around the world: emerging diseases challenging old concepts
    Philippe Parola
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Universite de la Mediterranee, Faculte de Medecine, 13385 Marseille Cedex 5, France
    Clin Microbiol Rev 18:719-56. 2005
    ..We present here the tick-borne rickettsioses described through 2005 and focus on the epidemiological circumstances that have played a role in the emergence of the newly recognized diseases...
  7. ncbi Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study
    C Suttinont
    Department of Medicine, Maharat Nakhon Ratchasima Hospital, Amphur Mueng, Nakhon Ratchasima Province, 30000, Thailand
    Ann Trop Med Parasitol 100:363-70. 2006
    ..Leptospirosis and rickettsioses, especially scrub typhus, were thus found to be major causes of acute, undifferentiated fever in Thai agricultural workers...
  8. ncbi Emerging and re-emerging tick-transmitted rickettsial and ehrlichial infections
    David H Walker
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
    Med Clin North Am 92:1345-61, x. 2008
    ..Globally, many of these bacteria have been named but the genetic differences among them are often small, and many of their clinical manifestations may not be distinguishable diagnostically...
  9. ncbi Infection and transovarial transmission of rickettsiae in Dermacentor variabilis ticks acquired by artificial feeding
    K R Macaluso
    Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore, Baltimore, MD 21201, USA
    Vector Borne Zoonotic Dis 1:45-53. 2001
    ..Examination by IFA of egg samples from females exposed to rickettsiae-infected cells identified rickettsiae in 100% of the samples tested, while the uninfected controls were negative...
  10. ncbi Molecular evidence supports the role of dogs as potential reservoirs for Rickettsia felis
    Sze Fui Hii
    School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia
    Vector Borne Zoonotic Dis 11:1007-12. 2011
    ..felis. A high prevalence of R. felis in dogs in our study suggests that dogs may act as an important reservoir host for R. felis and as a potential source of human rickettsial infection...
  11. pmc Flea-borne rickettsioses: ecologic considerations
    A F Azad
    Department of Microbiology and Immunobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Emerg Infect Dis 3:319-27. 1997
    ..We reviewed the ecology of R. typhi and R. felis and present recent data relevant to the vector biology, immunology, and molecular characterization and phylogeny of flea-borne rickettsioses...
  12. pmc Rickettsia felis-associated uneruptive fever, Senegal
    Cristina Socolovschi
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, 13385 Marseille, France
    Emerg Infect Dis 16:1140-2. 2010
    ..Using molecular tools, we found evidence for Rickettsia felis-associated illness in the initial days of infection in febrile Senegalese patients without malaria...
  13. pmc Human Infection with Rickettsia felis, Kenya
    Allen L Richards
    Naval Medical Research Center, Silver Spring, Maryland, USA
    Emerg Infect Dis 16:1081-6. 2010
    ..The 6 febrile patients' symptoms included headache; nausea; and muscle, back, and joint pain. None of the patients had a skin rash...
  14. pmc Rickettsial infection in animals and Brazilian spotted fever endemicity
    Luis A Sangioni
    University of Sao Paulo, São, Sao Paulo, Brazil
    Emerg Infect Dis 11:265-70. 2005
    ..cajennense ticks. In addition, we successfully performed experimental infection of A. cajennense ticks with R. parkeri...
  15. ncbi Ticks (Ixodidae) on humans in South America
    A A Guglielmone
    Instituto Nacional de Tecnologia Agropecuaria, Estacion Experimental Agropecuaria Rafaela, CC 22, CP 2300, Rafaela, Santa Fe, Argentina
    Exp Appl Acarol 40:83-100. 2006
    ..Indeed, there is only one record of an Ixodes collected while feeding on man for all South America...
  16. ncbi Tick- and flea-borne rickettsial emerging zoonoses
    Philippe Parola
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 5, France
    Vet Res 36:469-92. 2005
    ..We present here an overview of the various tick- and flea-borne rickettsial zoonoses described in the last 20 years, focusing on the ecological, epidemiological and clinical aspects...
  17. ncbi Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever
    Christopher D Paddock
    Infectious Diseases Pathology Branch, Mailstop G 32, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Clin Infect Dis 47:1188-96. 2008
    ..parkeri and comment on distinctions between R. parkeri rickettsiosis and other United States rickettsioses...
  18. ncbi Amblyomma triste Koch, 1844 (Acari: Ixodidae): hosts and seasonality of the vector of Rickettsia parkeri in Uruguay
    J M Venzal
    Departamento de Parasitología Veterinaria, Facultad de Veterinaria, Universidad de la Republica, Av Alberto Lasplaces 1620, CP 11600 Montevideo, Uruguay
    Vet Parasitol 155:104-9. 2008
    ..The main animal host for adult A. triste at our study sites was the domestic dog. Humans were afflicted by the tick in rural and suburban settlements where other host animals are scarce or extinct and where dogs are common...
  19. ncbi Rickettsiae and rickettsial infections: the current state of knowledge
    David H Walker
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Clin Infect Dis 45:S39-44. 2007
    ..However, disseminated intravascular coagulation rarely occurs. Immunity is mediated by reactive cytokine-activated rickettsicidal nitrogen and oxygen species and by clearance of rickettsiae by cytotoxic CD8 T cells...
  20. ncbi Detection of a novel spotted fever group rickettsia in Amblyomma parvum ticks (Acari: Ixodidae) from Argentina
    Richard C Pacheco
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Dr Orlando Marques de Paiva 87, Cidade Universitaria, Sao Paulo, SP 05508 270, Brazil
    Exp Appl Acarol 43:63-71. 2007
    ..strain Argentina as a human pathogen is unknown. Further studies are needed to obtain tissue-cultured isolates of Rickettsia sp. strain Argentina, in order to better characterize it and to determine its taxonomic status as a new species...
  21. pmc Diagnostic assay for Rickettsia japonica
    Nozomu Hanaoka
    National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Emerg Infect Dis 15:1994-7. 2009
    ..japonica genome project. The target ORF was present only in R. japonica-related strains...
  22. ncbi Rickettsioses in Japan and the far East
    Fumihiko Mahara
    Mahara Hospital, 6 1, Aratano, Anan city, Tokushima, 779 1510, Japan
    Ann N Y Acad Sci 1078:60-73. 2006
    ..These serotypes are of uncertain clinical significance. Epidemiology of rickettsioses in the Far East is mentioned briefly...
  23. ncbi Rickettsioses in Australia
    Stephen Graves
    Director, Australian Rickettsial Reference Laboratory, Geelong, Victoria, Australia
    Ann N Y Acad Sci 1166:151-5. 2009
    ..honei, strain "marmionii") in eastern Australia; Rickettsia felis, Western Australia; eight new RFG rickettsiae from ticks (of unknown pathogenicity); and two nonhuman pathogens in A. platys (dogs) and A. marginale (cattle)...
  24. pmc A patient from Argentina infected with Rickettsia massiliae
    Juan Carlos García-García
    Servicio de Medicina Interna, Hospital do Salnés, Villagarcia de Arosa, Pontevedra, Spain
    Am J Trop Med Hyg 82:691-2. 2010
    ..After treatment with doxycycline for 12 days, her symptoms resolved. Rickettsia massiliae infection was diagnosed by molecular-based detection of the microorganism in a biopsy specimen of the eschar...
  25. pmc Eschar-associated spotted fever rickettsiosis, Bahia, Brazil
    Nanci Silva
    Medicine and Public Health School of Bahia, Salvador, Brazil
    Emerg Infect Dis 17:275-8. 2011
    ..The etiologic agent is most related to Rickettsia parkeri, R. africae, and R. sibirica and probably widely distributed from Sao Paulo to Bahia in the Atlantic Forest...
  26. pmc Japanese spotted fever, South Korea
    Moon Hyun Chung
    Inha University College of Medicine, Incheon, South Korea
    Emerg Infect Dis 12:1122-4. 2006
    ..The isolated rickettsia from the patient was identified as Rickettsia japonica by analysis of the nucleotide sequences of 16S rRNA, gltA, ompA, ompB, and sca4 genes...
  27. pmc Rickettsia monacensis and human disease, Spain
    Isabel Jado
    Centro Nacional de Microbiologia, Majadahonda, Madrid, Spain
    Emerg Infect Dis 13:1405-7. 2007
    ..This finding increases the number of recognized human rickettsial pathogens and expands the known geographic distribution of Mediterranean spotted fever-like cases...
  28. ncbi Rickettsia parkeri as a paradigm for multiple causes of tick-borne spotted fever in the western hemisphere
    Christopher D Paddock
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Ann N Y Acad Sci 1063:315-26. 2005
    ..parkeri as a cause of disease in humans will hopefully encourage a closer examination for specific etiologies of tick-borne spotted fever rickettsioses in the United States and other countries of the Western Hemisphere...
  29. pmc Molecular evidence of Rickettsia felis infection in dogs from Northern Territory, Australia
    Sze Fui Hii
    School of Veterinary Science, The University of Queensland, Gatton, Queensland 4343, Australia
    Parasit Vectors 4:198. 2011
    ..felis. Rickettsia felis ompB and gltA genes were amplified from the blood of 3 dogs. This study is the first report of R. felis infection in indigenous community dogs in NT...
  30. ncbi Serological evidence for the continued presence of human rickettsioses in southern India
    E Mathai
    Department of Clinical Microbiology, Christian Medical College Hospital, Vellore, Tamil Nadu 632004, India
    Ann Trop Med Parasitol 95:395-8. 2001
    ..The epidemiology and magnitude of the problem need to be evaluated...
  31. pmc Typhus and other rickettsioses: emerging infections in Germany
    Gerhard Dobler
    Institut fur Mikrobiologie der Bundeswehr, Munchen, Germany
    Dtsch Arztebl Int 106:348-54. 2009
    ..Rickettsioses are diseases caused by rickettsiae, obligate intracellular bacteria that are transmitted by arthropods to humans. They cause various types of spotted fever and typhus...
  32. ncbi Seroepidemiological study of Rickettsia felis, Rickettsia typhi, and Rickettsia conorii infection among the population of southern Spain
    M Bernabeu-Wittel
    Department of Infectious Diseases, Hospitales Universitarios Virgen del Rocio, Avenida Manuel Siurot s n, 41013, Seville, Spain
    Eur J Clin Microbiol Infect Dis 25:375-81. 2006
    ..3; 95%CI 3.7-23.2), and participation in outdoor activities (OR=7.2; 95%CI 1.4-38.5). The results confirm the widespread prevalence of past infection due to R. felis, R. typhi, and R. conorii in the population of southern Spain...
  33. ncbi Seroprevalence of Rickettsia spp. infection among tick-bitten patients and blood donors in Sweden
    Karin Elfving
    From the Departments of Microbiology, Falu Central Hospital, Falu, Sweden
    Scand J Infect Dis 40:74-7. 2008
    ..Owing to a known occurrence of immunological cross-reactivites, however, the results must be cautiously interpreted with regard to species of Rickettsia involved...
  34. pmc Japanese spotted fever: report of 31 cases and review of the literature
    F Mahara
    Mahara Hospital, Tokushima, Japan
    Emerg Infect Dis 3:105-11. 1997
    ..Recent surveys show ticks to be the most probable vectors. As an emerging infectious disease, JSF is not commonly recognized by clinicians; therefore, even though it has not caused fatal cases, it merits careful monitoring...
  35. ncbi Concomitant or consecutive infection with Coxiella burnetii and tickborne diseases
    J M Rolain
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 40:82-8. 2005
    ..In this study, we describe 6 patients with Q fever who were infected with 1 of the following tickborne pathogens: Rickettsia conorii (2 patients), Rickettsia slovaca (2), Rickettsia africae (1), and Francisella tularensis (1)...
  36. pmc Rickettsia parkeri in Argentina
    Santiago Nava
    Instituto Nacional de Tecnologia Agropecuaria, Santa Fe, Argentina
    Emerg Infect Dis 14:1894-7. 2008
    ..When evaluated by PCR, 17 (7.6%) of 223 questing adult A. triste ticks, collected from 2 sites in the lower Paraná River Delta, contained DNA of Rickettsia parkeri...
  37. pmc Rickettsia parkeri in Amblyomma triste from Uruguay
    Jose M Venzal
    Departamento de Parasitología Veterinaria, Facultad de Veterinaria, Universidad de la Republica, Montevideo, Uruguay
    Emerg Infect Dis 10:1493-5. 2004
    ..Rickettsia parkeri was detected in A. triste, which suggests that this species could be considered a pathogenic agent responsible for human rickettsioses in Uruguay...
  38. pmc Spotted fever group and typhus group rickettsioses in humans, South Korea
    Yeon Joo Choi
    Konkuk University, Choongbuk, Republic of Korea
    Emerg Infect Dis 11:237-44. 2005
    ..These findings suggest that several kinds of rickettsial diseases, including boutonneuse fever, rickettsialpox, R. felis infection, and Japanese spotted fever, as well as scrub typhus and murine typhus, are occurring in Korea...
  39. pmc Rickettsia parkeri in Brazil
    Iara Silveira
    University of Sao Paulo, Sao Paulo, Brazil
    Emerg Infect Dis 13:1111-3. 2007
    ..An R. parkeri isolate was successfully established in Vero cell culture. Molecular characterization of the agent was performed by DNA sequencing of portions of the rickettsial genes gltA, htrA, ompA, and ompB...
  40. ncbi Tropical rickettsioses
    Philippe Parola
    Unite des Rickettsies CNRS UMR 6020, IFR48, WHO Collaborative Center for Rickettsial Reference and Research, Medicine School of Marseille, France
    Clin Dermatol 24:191-200. 2006
    ..We also present an update on the emerging spotted fever group rickettsioses described in the tropics through 2005, focusing on epidemiologic and clinical data and management...
  41. pmc Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens
    Hiroyuki Ogata
    Structural and Genomic Information Laboratory, Centre National de la Recherche Scientifique UPR 2589, Institut de Biologie Structurale et Microbiologie, Parc Scientifique de Luminy, Marseille, France
    PLoS Genet 2:e76. 2006
    ....
  42. ncbi Current knowledge on phylogeny and taxonomy of Rickettsia spp
    Pierre Edouard Fournier
    Unite des Rickettsies, CNRS IRD UMR 6236, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    Ann N Y Acad Sci 1166:1-11. 2009
    ..These data were incorporated into polyphasic consensus guidelines that provide clear recommendations for the taxonomic classification and nomenclature of rickettsiae and rickettsial diseases...
  43. pmc Cluster of cases of human Rickettsia felis infection from Southern Europe (Spain) diagnosed by PCR
    Jose A Oteo
    Area de Enfermedades Infecciosas, Complejo Hospitalario San Millán San Pedro de La Rioja, Avda Viana, 1, 26001 Logroño La Rioja, Spain
    J Clin Microbiol 44:2669-71. 2006
    ..The first cluster of cases of human Rickettsia felis infection in Spain diagnosed by PCR is reported...
  44. ncbi Rickettsioses and the international traveler
    Mogens Jensenius
    Department of Internal Medicine, Aker University Hospital, Oslo, Norway
    Clin Infect Dis 39:1493-9. 2004
    ..Tetracyclines are the drugs of first choice and should be prescribed whenever a case of rickettsiosis is suspected. Preventive measures rely on minimizing the risk of arthropod bites when traveling in areas of endemicity...
  45. pmc The infective causes of hepatitis and jaundice amongst hospitalised patients in Vientiane, Laos
    Bounkong Syhavong
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Trans R Soc Trop Med Hyg 104:475-83. 2010
    ..These patients would be expected to respond to empirical doxycycline therapy which, in the absence of virological diagnosis and treatment, may be an appropriate cost-effective intervention in Lao patients with jaundice/hepatitis...
  46. ncbi Brazilian spotted fever: a case series from an endemic area in southeastern Brazil: clinical aspects
    Rodrigo N Angerami
    Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Ann N Y Acad Sci 1078:252-4. 2006
    ..The presence of the classical triad of fever, rash, and headache as described in RMSF was observed in fever than half (35.2%) of our patients...
  47. pmc Rickettsia felis in Ctenocephalides spp. fleas, Brazil
    Riva P Oliveira
    Departamento de Nutrição Clínica e Social, Escola de Nutrição, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto Minas Gerais State, Brazil CEP 34 500 000
    Emerg Infect Dis 8:317-9. 2002
    ..The nucleotide sequence alignment of the 391-bp segment of the 17-kDa protein gene showed that the products were identical to each other and to the R. felis 17-kDa gene, confirming circulation of R. felis in Brazil...
  48. pmc Rickettsia parkeri Rickettsiosis, Argentina
    Yamila Romer
    Hospital F J Muñiz, Buenos Aires, Argentina
    Emerg Infect Dis 17:1169-73. 2011
    ..Many R. parkeri infections in South America are likely to be misdiagnosed as other infectious diseases, including Rocky Mountain spotted fever, dengue, or leptospirosis...
  49. ncbi Pathogenic mechanisms of diseases caused by Rickettsia
    David H Walker
    University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Ann N Y Acad Sci 990:1-11. 2003
    ..The host cell receptor for the Rickettsia ligand and the mechanism of rickettsial escape from the phagosome need to be elucidated...
  50. ncbi Serological evidence of Rickettsia infections in forestry rangers in north-eastern Italy
    M Cinco
    Laboratorio Spirochete, Dipartimento di Scienze Biomediche, Universita di Trieste, Trieste, Italy
    Clin Microbiol Infect 12:493-5. 2006
    ..8%) sera, four of which were also positive for B. burgdorferi. These findings indicate that patients in this north-eastern Italian region with fever subsequent to tick-bite should be investigated for Rickettsia and Coxiella infections...
  51. pmc Simultaneous detection of "Rickettsia mongolotimonae" in a patient and in a tick in Greece
    Anna Psaroulaki
    Laboratory of Clinical Bacteriology, Parasitology, Zoonoses, and Geographical Medicine, University of Crete, Crete, Greece
    J Clin Microbiol 43:3558-9. 2005
    ..Here, we report the presence of "Rickettsia mongolotimonae" (proposed name) detected simultaneously in a patient and in a Hyalomma anatolicum excavatum tick, sampled on the patient...
  52. pmc Rickettsia mongolotimonae infection in South Africa
    Anne Marie Pretorius
    Department of Medical Microbiology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa
    Emerg Infect Dis 10:125-6. 2004
    ..After a regimen of doxycycline, symptoms rapidly resolved. R. mongolotimonae infection was diagnosed retrospectively by serologic tests and molecular-based detection of the organism in biopsy specimens of eschar material...
  53. ncbi Characterization of a tandem repeat polymorphism in Rickettsia strains
    Liliana Vitorino
    Universidade de Lisboa, Faculdade de Ciencias, Centro de Genética e Biologia Molecular and Instituto de Ciência Aplicada e Tecnologia, Edificio ICAT, Campus FCUL, Campo Grande 1749 016 Lisboa, Portugal
    J Med Microbiol 54:833-41. 2005
    ..PCR amplification of the Rc-65 locus can be used to differentiate between the Portuguese R. conorii Malish-like and Israeli tick typhus strains, enabling a more accurate and rapid identification of these rickettsial isolates...
  54. ncbi Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay
    Jose M Venzal
    Departamento de Parasitología Veterinaria, Facultad de Veterinaria, Universidad de la Republica, Salto, Uruguay
    Rev Inst Med Trop Sao Paulo 54:131-4. 2012
    ..parkeri. These findings, joint with the aggressiveness shown by A. triste towards humans, support previous data on the involvement of A. triste as vector of human infections caused by R. parkeri in Uruguay...
  55. ncbi Analysis of immunoprotectivity of the recombinant OmpA of Rickettsia heilongjiangensis
    Yanmei Jiao
    Beijing Institute of Microbiology and Epidemiology and State Key Laboratory of Pathogen and Biosecurity, Fengtai, Beijing 100071, China
    Ann N Y Acad Sci 1063:261-5. 2005
    ..These results suggest that the truncated OmpA of R. heilongjiangii is immunogenic for effectively inducing humoral and cell-mediated immune responses against homologous and heterologous species in the spotted fever group...
  56. pmc Lymphangitis in a Portuguese patient infected with Rickettsia sibirica
    Rita de Sousa
    Emerg Infect Dis 14:529-30. 2008
  57. pmc Human infection with Rickettsia sp. related to R. japonica, Thailand
    Jariyanart Gaywee
    Emerg Infect Dis 13:671-3. 2007
  58. pmc Molecular method for identification of Rickettsia species in clinical and environmental samples
    Isabel Jado
    Laboratorio de Espiroquetas y Patógenos Especiales, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 44:4572-6. 2006
    ..The method is highly sensitive and specific in identifying Rickettsia species from both patient and environmental samples. The generic approach used allowed us to identify new pathogens...
  59. ncbi Characterization of rickettsial diseases in a hospital-based population in central Tunisia
    Naoufel Kaabia
    Infectious Diseases Unit, Farhat Hached, University Hospital Sousse Tunisia, Tunisia
    Ann N Y Acad Sci 1166:167-71. 2009
    ..Doxycycline should be prescribed in patients with acute fever and skin rash, especially in hot seasons. These rickettsioses were characterized by benign prognosis. More skin biopsies are needed to identify other SFG rickettsies...
  60. pmc First documented human Rickettsia aeschlimannii infection
    Didier Raoult
    Emerg Infect Dis 8:748-9. 2002
  61. ncbi Emerging rickettsial infections in Sri Lanka: the pattern in the hilly Central Province
    S A M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Trop Med Int Health 8:803-11. 2003
    ....
  62. ncbi Detection of antibodies against spotted fever group Rickettsia (SFGR), typhus group Rickettsia (TGR), and Coxiella burnetii in human febrile patients in the Philippines
    Gerry Amor Camer
    College of Veterinary Medicine, University of Eastern Philippines, Catarman, Northern Samar, Philippines
    Jpn J Infect Dis 56:26-8. 2003
    ..5% for TGR (R. typhus), respectively. Rickettsial antibodies in humans in the Philippines were found for the first time. These results underscore the need for further epidemiological study of clinical rickettsioses in the Philippines...
  63. ncbi Detection of Rickettsia parkeri and Candidatus Rickettsia andeanae in Amblyomma maculatum Gulf Coast ticks collected from humans in the United States
    Ju Jiang
    Naval Medical Research Center, Silver Spring, Maryland, USA
    Vector Borne Zoonotic Dis 12:175-82. 2012
    ..andeanae, respectively, by newly developed genus- and species-specific quantitative real-time polymerase chain reaction assays. In addition Rickettsia felis was found in two A. maculatum nucleic acid preparations...
  64. ncbi Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment
    R Premaratna
    Department of Medicine, Faculty of Medicine, University of Kelaniya PO Box 6, Thalagolla Road, Ragama, Sri Lanka ranjan
    Trans R Soc Trop Med Hyg 104:368-70. 2010
    ..This suggests that greater use of doxycycline appears justified for patients with undiagnosed fever in settings where rickettsial diseases are endemic or re-emerging with inadequate diagnostic facilities...
  65. ncbi Rickettsia honei sp. nov., the aetiological agent of Flinders Island spotted fever in Australia
    J Stenos
    Department of Pathology, University of Texas Medical Branch, Galveston 77550 0609, USA
    Int J Syst Bacteriol 48:1399-404. 1998
    ..Indeed, it is proposed that TT-118 is a strain of R. honei which was previously isolated in Thailand. These results elucidate the presence of a unique SFG rickettsial species in Australasia...
  66. ncbi Rickettsia infection in dogs and Rickettsia parkeri in Amblyomma tigrinum ticks, Cochabamba Department, Bolivia
    Laura Tomassone
    Department of Animal Production, Epidemiology and Ecology, University of Turin, Grugliasco, Torin, Italy
    Vector Borne Zoonotic Dis 10:953-8. 2010
    ..Our study supports the use of canine serology as risk indicator for SF rickettsioses...
  67. ncbi Rickettsiosis of the genus Rickettsia in South America
    Marcio A M Galvao
    Departamento de Nutrição Clínica e Social, Escola de Nutrição, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil 35400 000
    Ann N Y Acad Sci 990:57-61. 2003
    ....
  68. ncbi Infection by spotted fever rickettsiae in people, dogs, horses and ticks in Londrina, Parana State, Brazil
    R S Toledo
    Programa de Pós Graduação em Ciência Animal, Universidade Estadual de Londrina, PR, Brazil
    Zoonoses Public Health 58:416-23. 2011
    ..Nonetheless, as humans of the present study are highly exposed to tick infestations, health education within the population is needed to obtain efficient tick control...
  69. pmc Isolation of a rickettsial pathogen from a non-hematophagous arthropod
    Chutima Thepparit
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
    PLoS ONE 6:e16396. 2011
    ..felis provides an excellent model for the study of rickettsial pathogenesis and transmission. In addition, this study is the first isolation of a rickettsial pathogen from a non-hematophagous arthropod...
  70. ncbi Urban focus of Rickettsia typhi and Rickettsia felis in Los Angeles, California
    Kyle F Abramowicz
    National Center for Zoonotic and Emerging Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Gerogia 30333, USA
    Vector Borne Zoonotic Dis 11:979-84. 2011
    ..3%, respectively. Although R. typhi still circulates in urban Los Angeles in the classic Oriental flea-rat cycle, R. felis is more prevalent, even in this association...
  71. ncbi Spectrum of disease and relation to place of exposure among ill returned travelers
    David O Freedman
    Division of Geographic Medicine, University of Alabama at Birmingham, Birmingham, USA
    N Engl J Med 354:119-30. 2006
    ..Approximately 8 percent of travelers to the developing world require medical care during or after travel. Current understanding of morbidity profiles among ill returned travelers is based on limited data from the 1980s...
  72. ncbi Mechanisms of immunity against rickettsiae. New perspectives and opportunities offered by unusual intracellular parasites
    Gustavo Valbuena
    Department of Pathology and WHO Collaborating Center for Tropical Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston 77555 0609, USA
    Microbes Infect 4:625-33. 2002
    ....
  73. ncbi Seroprevalence of Rickettsia bellii and Rickettsia felis in dogs, São José dos Pinhais, State of Paraná, Brazil
    Fernanda Silva Fortes
    Laboratório de Doenças Parasitárias, Departamento de Medicina Veterinaria, Faculdade de Medicina Veterinaria, Universidade Federal do Parana, Rua dos Funcionários 1540, Curitiba PR, Brazil
    Rev Bras Parasitol Vet 19:222-7. 2010
    ..circulation in dogs in the area studied may be considered at low prevalence, suggesting low risk of human infection, the present data demonstrate for the first time the exposure of dogs to R. bellii and R. felis in Southern Brazil...
  74. pmc Rickettsia sibirica subsp. mongolitimonae infection and retinal vasculitis
    Julie Caron
    Emerg Infect Dis 14:683-4. 2008
  75. ncbi Ecology of Rickettsia felis: a review
    Kathryn E Reif
    Department of Pathobiological Sciences, Louisiana State University, School of Veterinary Medicine, Skip Bertman Dr, Baton Rouge, LA 70803, USA
    J Med Entomol 46:723-36. 2009
    ..felis including the known distribution and arthropods infected; transmission mechanisms; current understanding of vertebrate infection and human disease; and the tools available to further examine R. felis...
  76. ncbi Molecular identification of Rickettsia felis in ticks and fleas from an endemic area for Brazilian Spotted Fever
    K A Oliveira
    Laboratório de Bioquímica e Biologia Molecular de Agentes Infecciosos e Parasitários, Depatamento de Bioquímica e Biologia Molecular, Universidade Federal de Vicosa, Vicosa, MG, 36570 000, Brasil
    Mem Inst Oswaldo Cruz 103:191-4. 2008
    ..Moreover, they show the needing of further studies for deeper knowledge of R. felis-spotted fever epidemiology and differentiation of these diseases in Brazil...
  77. ncbi Aponomma hydrosauri, the reptile-associated tick reservoir of Rickettsia honei on Flinders Island, Australia
    John Stenos
    Australian Rickettsial Reference Laboratory, The Geelong Hospital, Geelong, Victoria, Australia
    Am J Trop Med Hyg 69:314-7. 2003
    ..From the positive tick samples, seven were sequenced and found to be 100% homologous with R. honei. Of 17 reptiles examined, none had evidence of rickettsiae by PCR or culture of blood...
  78. ncbi Serologic study of rickettsioses among acute febrile patients in central Tunisia
    N Kaabia
    Service de Medecine Interne et Maladies Infectieuses, CHU F, Hached Sousse 4000 Tunisia
    Ann N Y Acad Sci 1078:176-9. 2006
    ..We concluded that SFGR, murine typhus, and acute Q fever are common causes of acute isolate fever in summer in central Tunisia and should be investigated systematically in patients with acute fever of unknown origin...
  79. ncbi Septic shock in a patient infected with Rickettsia sibirica mongolitimonae, Spain
    V Ibarra
    Area de Enfermedades Infecciosas, Hospital San Pedro Centro de Investigación Biomédica de La Rioja, La Rioja, Spain
    Clin Microbiol Infect 18:E283-5. 2012
    ..We report a case of R. sibirica mongolitimonae infection as a cause of septic shock in a Spanish patient living in La Rioja (northern Spain). In addition, the broad clinical spectrum of this tick-borne disease is discussed...
  80. pmc Rickettsia felis, Bartonella henselae, and B. clarridgeiae, New Zealand
    Patrick J Kelly
    Emerg Infect Dis 10:967-8. 2004
  81. ncbi Septicaemia with Rickettsia helvetica in a patient with acute febrile illness, rash and myasthenia
    K Nilsson
    Section of Clinical Microbiology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    J Infect 58:79-82. 2009
    ..helvetica in the blood was verified by PCR together with serologic evidence of infection, the patient presented a different clinical picture with acute febrile illness, rash and long-lasting myasthenia...
  82. ncbi Imported spotted fever rickettsioses in United States travelers returning from Africa: a summary of cases confirmed by laboratory testing at the Centers for Disease Control and Prevention, 1999-2002
    Jennifer H McQuiston
    Viral and Rickettsial Zoonoses Branch, and Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 70:98-101. 2004
    ....
  83. pmc Wide dispersal and possible multiple origins of low-copy-number plasmids in rickettsia species associated with blood-feeding arthropods
    Gerald D Baldridge
    Department of Entomology, University of Minnesota, 1980 Folwell Ave, St Paul, MN 55108, USA
    Appl Environ Microbiol 76:1718-31. 2010
    ....
  84. ncbi Markers of exposure to spotted fever rickettsiae in patients with chronic illness, including fatigue, in two Australian populations
    N Unsworth
    Australian Rickettsial Reference Laboratory, Barwon Biomedical Research, Geelong, Victoria, Australia
    QJM 101:269-74. 2008
    ..Some investigators believe that a proportion of chronically unwell patients, many with fatigue, have an underlying rickettsial disease...
  85. pmc Identification of rickettsial infections by using cutaneous swab specimens and PCR
    Yassina Bechah
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 17:83-6. 2011
    ..Specimens from eschars in guinea pigs were positive for rickettsiae as long as lesions were present. Optimal storage temperature for specimens was 4 degrees C for 3 days...
  86. ncbi Rickettsial infections and their clinical presentations in the Western Province of Sri Lanka: a hospital-based study
    R Premaratna
    Department of Medicine, Faculty of Medicine, University of Kelaniya, PO Box 6, Thalagolla Rd, Ragama, Sri Lanka
    Int J Infect Dis 12:198-202. 2008
    ..Rickettsial infections are re-emerging. A study of the geographical distribution of rickettsial infections, their clinical manifestations, and their complications would facilitate early diagnosis...
  87. pmc Prevalence and infection load dynamics of Rickettsia felis in actively feeding cat fleas
    Kathryn E Reif
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America
    PLoS ONE 3:e2805. 2008
    ..We hypothesized that within colonized fleas, the intimate relationship between R. felis and C. felis allows for the coordination of rickettsial replication and metabolically active periods during flea bloodmeal acquisition and oogenesis...
  88. ncbi Causes of fever in adults on the Thai-Myanmar border
    Ruth D Ellis
    Armed Forces Research Institute for Medical Sciences AFRIMS, Bangkok, Thailand
    Am J Trop Med Hyg 74:108-13. 2006
    ..Apparent dual diagnoses were common, particularly for malaria and leptospirosis. Findings have been used to modify treatment of unspecified febrile illness in the area...
  89. pmc Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever
    Mogens Jensenius
    Department of Internal Medicine, Aker University Hospital, Oslo, Norway
    Clin Diagn Lab Immunol 11:786-8. 2004
    ..01). A specific diagnosis of Rickettsia africae infection could be established in 15% of the patients by IFA and in 73% of the patients by a combination of WB and cross-adsorption assays (P < 0.01)...
  90. ncbi Prevalence of Rickettsia infection in dogs from the urban and rural areas of Monte Negro municipality, western Amazon, Brazil
    Marcelo B Labruna
    Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Vector Borne Zoonotic Dis 7:249-55. 2007
    ..parkeri, R. amblyommii, and R. rhipicephali. While R. parkeri is a known human pathogen, further studies are required to verify the potential role of R. amblyommii and R. rhipicephali as human pathogens...
  91. pmc Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conorii
    Yong Zhu
    Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    BMC Microbiol 5:11. 2005
    ..Then, we selected a representative of each MLST genotype and used multi-spacer typing (MST) and mouse serotyping to estimate their degree of taxonomic relatedness...
  92. ncbi Survey of the vectorial competence of ticks in an endemic area of spotted fever group rickettsioses in Fukui Prefecture, Japan
    Fubito Ishiguro
    Fukui Prefectural Institute of Health and Environmental Science, Fukui, Fuku 910 8551, Japan
    Microbiol Immunol 52:305-9. 2008
    ..japonica showed greater homology to R. japonica than to R. helvetica or R. asiatica. The present results indicate that it is most likely that the vector tick of R. helvetica infection in Fukui Prefecture is I. monospinosus...
  93. ncbi Molecular detection of Bartonella quintana, B. Elizabethae, B. Koehlerae, B. Doshiae, B. Taylorii, and Rickettsia felis in rodent fleas collected in Kabul, Afghanistan
    Jean Lou Marié
    Secteur Vétérinaire Interarmées, service de santé des armées, Toulouse, France
    Am J Trop Med Hyg 74:436-9. 2006
    ..These results emphasize the potential risk of flea-borne infections transmitted by rodents in this area, and suggest that preventive measures should be taken in the general framework of zoonoses management...
  94. pmc Gulf Coast ticks (Amblyomma maculatum) and Rickettsia parkeri, United States
    John W Sumner
    Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 13:751-3. 2007
    ..maculatum may be responsible for additional cases of R. parkeri rickettsiosis throughout much of its US range...
  95. pmc Rickettsial pathogens and their arthropod vectors
    A F Azad
    University of Maryland School of Medicine, Baltimore, USA
    Emerg Infect Dis 4:179-86. 1998
    ..This article examines the common features of the host-pathogen relationship and of the arthropod vectors of the typhus and spotted fever group rickettsiae...
  96. ncbi Prevalence of Rickettsia conorii and Rickettsia typhi infections in the population of northern Greece
    S Alexiou Daniel
    A Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Greece
    Am J Trop Med Hyg 66:76-9. 2002
    ..typhi. We also detected differences in the prevalence of rickettsial infections among the different prefectures. Our data show the wide distribution of R. conorii in northern Greece and indicate the presence of R. typhi...
  97. ncbi Polygenic detection of Rickettsia felis in cat fleas (Ctenocephalides felis) from Israel
    Omri Bauer
    School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
    Am J Trop Med Hyg 74:444-8. 2006
    ..Although no clinical case has been reported in human beings in Israel to date, these findings suggest that this infection is prevalent in Israel...
  98. ncbi Rickettsiosis in Europe
    J R Blanco
    Area de Enfermedades Infecciosas, Complejo San Millán San Pedro de La Rioja, Hospital de La Rioja, Avd Viana 1, 26001, Logroño La Rioja, Spain
    Ann N Y Acad Sci 1078:26-33. 2006
    ..Other rickettsioses exist that have not yet been implicated in human pathology. We should consider that climate changes and other factors could contribute to the emergence and reemergence of other new diseases...
  99. ncbi Rickettsia slovaca infection: DEBONEL/TIBOLA
    V Ibarra
    Area de Enfermedades Infecciosas, Hospitales San Millán San Pedro de La Rioja, Avda Viana No 1 26001 Logroño La Rioja, Spain
    Ann N Y Acad Sci 1078:206-14. 2006
    ..strains RpA4, DnS14, and DnS28. All ticks removed from patients were PCR-positive. Sequencing showed 8 of them identified as R. slovaca and 2 as Rickettsia sp. strains RpA4, DnS14, and DnS28...
  100. ncbi Rickettsia as obligate and mycetomic bacteria
    M Alejandra Perotti
    School of Biological Sciences, University of Wales Bangor, Bangor, Gwynedd LL57 2UW, UK
    FASEB J 20:2372-4. 2006
    ..In two phylogenetically distant psocopteran species, Rickettsia are shown to be associated with four transitional stages from free bacteria, infected cells, through single mycetocytes to organ-forming mycetomes...
  101. pmc Rickettsia mongolotimonae: a rare pathogen in France
    P E Fournier
    , , Marseille, France
    Emerg Infect Dis 6:290-2. 2000
    ..This pathogen should be systematically considered in the differential diagnosis of atypical rickettsioses, especially rashless fevers with lymphangitis and lymphadenopathy, in southern France and perhaps elsewhere...

Research Grants13

  1. The Role of Plasmids in Rickettsia Biology
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..The results of this research may provide new tools to control Rickettsia infections of humans.
  2. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..
  3. Gammacell-220 Excel Refurbished Research Irradiator
    David Walker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. BIOLOGY AND IMMUNOLOGY OF MALARIA PARASITE LIVER-STAGES
    Abdu Azad; Fiscal Year: 2005
    ..falciparum EE-stages. Finally, we will define the contribution of P. yoelii liver-stage gene products in protective immunity via DNA immunizations. ..
  5. Murine Typhus: Vector Biology & Transmission
    Abdu Azad; Fiscal Year: 2007
    ..typhi and ELB upon challenge with[unreadable] the heterologous rickettsiae and involvement of 120 kDa in the protection.[unreadable] [unreadable]..
  6. Generation of Genetically Attenuated Rickettsiae
    Abdu Azad; Fiscal Year: 2009
    ..The underlying hypothesis tested is whether recombinant strains with altered genes maintain their immunogenicity within mammals and provide cross protection to subsequent challenge with virulent strains. ..
  7. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ....
  8. Modulation of Host Cell Apoptosis By Pathogenic Rickettsiae
    SANJEEV SAHNI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. Comparative rickettsial protein profiles during tick infection
    KEVIN MACALUSO; Fiscal Year: 2007
    ..To better understand the mechanisms of rickettsial virulence, this project seeks to examine the interplay between spotted fever group Rickettsia and the vector tick. [unreadable] [unreadable] [unreadable]..
  10. RICKETTSIA-INDUCED TRANSCRIPTIONAL ACTIVATION
    SANJEEV SAHNI; Fiscal Year: 2007
    ..These studies will offer important perspectives in our understanding of rickettsial pathogenesis and may lead to the identification of novel targets for supplemental chemotherapy. ..
  11. Molecular dynamics of rickettsial infection in ticks
    KEVIN MACALUSO; Fiscal Year: 2006
    ..These studies will further our understanding of both tick physiology and rickettsial transmission. ..
  12. Tick Susceptibility and Response to Rickettsiae
    KEVIN MACALUSO; Fiscal Year: 2004
    ..Together, these experiments will further our understanding of the tick-rickettsiae relationship. ..