mycoplasma infections

Summary

Summary: Infections with species of the genus MYCOPLASMA.

Top Publications

  1. pmc Molecular biology and pathogenicity of mycoplasmas
    S Razin
    Department of Membrane and Ultrastructure Research, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Microbiol Mol Biol Rev 62:1094-156. 1998
  2. ncbi Interaction of mycoplasmas with host cells
    Shlomo Rottem
    Department of Membrane and Ultrastructure Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Physiol Rev 83:417-32. 2003
  3. ncbi A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men
    Leandro A Mena
    University of Mississippi Medical Center, Div of Infectious Diseases, 2500 N State St, Jackson, MS 39216, USA
    Clin Infect Dis 48:1649-54. 2009
  4. pmc Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells
    Kazunori Namiki
    Department of Urology, The University of Florida, Gainesville, Florida, USA
    PLoS ONE 4:e6872. 2009
  5. pmc Mycoplasmas and ureaplasmas as neonatal pathogens
    Ken B Waites
    Department of Pathology, University of Alabama, Birmingham, Alabama 35249, USA
    Clin Microbiol Rev 18:757-89. 2005
  6. pmc Use of TaqMan 5' nuclease real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic
    Jørgen Skov Jensen
    Mycoplasma Laboratory, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
    J Clin Microbiol 42:683-92. 2004
  7. pmc Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae
    Ana Tereza R Vasconcelos
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenida Bento Goncalves 9500, Prédio 43421, Porto Alegre, RS, Brazil
    J Bacteriol 187:5568-77. 2005
  8. ncbi Hemotrophic mycoplasmas (hemoplasmas): a review and new insights into pathogenic potential
    Joanne B Messick
    College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, 61802, USA
    Vet Clin Pathol 33:2-13. 2004
  9. ncbi Mycoplasma leachii sp. nov. as a new species designation for Mycoplasma sp. bovine group 7 of Leach, and reclassification of Mycoplasma mycoides subsp. mycoides LC as a serovar of Mycoplasma mycoides subsp. capri
    L Manso-Silvan
    CIRAD, UMR 15 Control of Exotic and Emerging Animal Diseases, TA A 15 G, Campus International Baillarguet, 34398 Montpellier Cedex 5, France
    Int J Syst Evol Microbiol 59:1353-8. 2009
  10. pmc Mycoplasma genitalium: from Chrysalis to multicolored butterfly
    David Taylor-Robinson
    Chalfont St Giles, Bucks, United Kingdom
    Clin Microbiol Rev 24:498-514. 2011

Detail Information

Publications267 found, 100 shown here

  1. pmc Molecular biology and pathogenicity of mycoplasmas
    S Razin
    Department of Membrane and Ultrastructure Research, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Microbiol Mol Biol Rev 62:1094-156. 1998
    ....
  2. ncbi Interaction of mycoplasmas with host cells
    Shlomo Rottem
    Department of Membrane and Ultrastructure Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Physiol Rev 83:417-32. 2003
    ....
  3. ncbi A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men
    Leandro A Mena
    University of Mississippi Medical Center, Div of Infectious Diseases, 2500 N State St, Jackson, MS 39216, USA
    Clin Infect Dis 48:1649-54. 2009
    ..The present study compared the efficacy of 1 g of azithromycin given as a single dose with that of 100 mg of doxycycline given twice a day for 7 days in eliminating M. genitalium infection...
  4. pmc Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells
    Kazunori Namiki
    Department of Urology, The University of Florida, Gainesville, Florida, USA
    PLoS ONE 4:e6872. 2009
    ..genitalium or M. hyorhinis infection to lead to the malignant transformation of benign human epithelial cells and may serve as a model to further study the relationship between prostatitis and prostatic carcinogenesis...
  5. pmc Mycoplasmas and ureaplasmas as neonatal pathogens
    Ken B Waites
    Department of Pathology, University of Alabama, Birmingham, Alabama 35249, USA
    Clin Microbiol Rev 18:757-89. 2005
    ....
  6. pmc Use of TaqMan 5' nuclease real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic
    Jørgen Skov Jensen
    Mycoplasma Laboratory, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
    J Clin Microbiol 42:683-92. 2004
    ..Urethral swab specimens from patients with urethral discharge had a significantly higher DNA load than specimens from patients without discharge. This correlation was not found in first-void urine specimens...
  7. pmc Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae
    Ana Tereza R Vasconcelos
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenida Bento Goncalves 9500, Prédio 43421, Porto Alegre, RS, Brazil
    J Bacteriol 187:5568-77. 2005
    ..Horizontal gene transfer was consistently observed between M. synoviae and Mycoplasma gallisepticum. Our analyses indicated a likely transfer event of hemagglutinin-coding DNA sequences from M. gallisepticum to M. synoviae...
  8. ncbi Hemotrophic mycoplasmas (hemoplasmas): a review and new insights into pathogenic potential
    Joanne B Messick
    College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, 61802, USA
    Vet Clin Pathol 33:2-13. 2004
    ..Despite an intense immune response and even with antibiotic treatment, infected animals probably remain chronic carriers after clinical signs have resolved...
  9. ncbi Mycoplasma leachii sp. nov. as a new species designation for Mycoplasma sp. bovine group 7 of Leach, and reclassification of Mycoplasma mycoides subsp. mycoides LC as a serovar of Mycoplasma mycoides subsp. capri
    L Manso-Silvan
    CIRAD, UMR 15 Control of Exotic and Emerging Animal Diseases, TA A 15 G, Campus International Baillarguet, 34398 Montpellier Cedex 5, France
    Int J Syst Evol Microbiol 59:1353-8. 2009
    ..As a result of these emendments, the M. mycoides cluster will hereafter be composed of five taxa comprising three subclusters, which correspond to the M. mycoides subspecies, the M. capricolum subspecies and the novel species M. leachii...
  10. pmc Mycoplasma genitalium: from Chrysalis to multicolored butterfly
    David Taylor-Robinson
    Chalfont St Giles, Bucks, United Kingdom
    Clin Microbiol Rev 24:498-514. 2011
    ..Finally, aspects of the antimicrobial susceptibility and resistance of M. genitalium, together with the treatment and possible prevention of mycoplasmal disease, are discussed...
  11. pmc Human coinfection with Bartonella henselae and two hemotropic mycoplasma variants resembling Mycoplasma ovis
    Jane E Sykes
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
    J Clin Microbiol 48:3782-5. 2010
    ..Coinfection with similar variants has been described in sheep. This represents the first report of human infection with this organism. The veterinarian was coinfected with Bartonella henselae...
  12. ncbi Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance
    Jørgen S Jensen
    Mycoplasma Laboratory, Statens Serum Institut, Copenhagen, Denmark
    Clin Infect Dis 47:1546-53. 2008
    ..The aim of the study was to establish the reason for the occasional treatment failures...
  13. pmc Description of outcomes of experimental infection with feline haemoplasmas: copy numbers, haematology, Coombs' testing and blood glucose concentrations
    Severine Tasker
    School of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, United Kingdom
    Vet Microbiol 139:323-32. 2009
    ..haemofelis infection, in contrast to 'Candidatus M. haemominutum' and 'Candidatus M. turicensis' infection, can result in a severe macrocytic anaemia and the development of cold and warm reactive erythrocyte-bound antibodies...
  14. pmc Avoidance of the host immune system through phase variation in Mycoplasma pulmonis
    Amy M Denison
    Department of Genetics, KAUL, Room 720, University of Alabama at Birmingham, Birmingham, AL 35294 0024, USA
    Infect Immun 73:2033-9. 2005
    ..The data strongly indicate that Vsa phase variation is a mechanism for avoidance of the immune system with no obvious contribution to tissue tropism...
  15. ncbi Mycoplasma bovis: disease, diagnosis, and control
    R A J Nicholas
    Mycoplasma Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey KT15 3NB, UK
    Res Vet Sci 74:105-12. 2003
    ..bovis are becoming resistant to antibiotics, including tetracycline, tilmicosin and spectinomycin, traditionally used for their control. No vaccines are presently available for the control of M. bovis infections...
  16. pmc Mycoplasmoses of ruminants in France: recent data from the national surveillance network
    Myriam Chazel
    UMR Ruminant mycoplasmoses AFSSA Lyon, 31 avenue Tony Garnier 69364 Lyon cedex 07, France
    BMC Vet Res 6:32. 2010
    ..The VIGIMYC framework can also be used for specific surveys and one example, on the prevalence of M. bovis in bovine respiratory diseases, is presented here...
  17. ncbi Prevalence of Mycoplasma genitalium among female students in vocational schools in Japan
    R Hamasuna
    Division of Urology, Department of Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Sex Transm Infect 84:303-5. 2008
    ..The objective of this study was to determine the prevalence of M genitalium infection among younger females and to determine risk factors for this infection...
  18. pmc Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum
    S M Szczepanek
    Department of Pathobiology and Veterinary Science and Center of Excellence for Vaccine Research, University of Connecticut, Storrs, Connecticut 06269, USA
    Infect Immun 78:1760-71. 2010
    ..Together, these data provide novel insights into inter- and intrastrain M. gallisepticum genomic variability and the genetic basis of M. gallisepticum virulence...
  19. pmc A novel hemotropic Mycoplasma (hemoplasma) in a patient with hemolytic anemia and pyrexia
    Jane A Steer
    Department of Microbiology, Derriford Hospital, Plymouth, United Kingdom
    Clin Infect Dis 53:e147-51. 2011
    ..A clinical response to doxycyline was noted, and moxifloxacin was added subsequently to aid infection clearance. This represents the first report of hemolysis in association with confirmed hemoplasma infection in a human...
  20. pmc Roles of innate and adaptive immunity in respiratory mycoplasmosis
    S C Cartner
    Department of Comparative Medicine, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 66:3485-91. 1998
    ....
  21. pmc Mycoplasma genitalium: an emerging cause of sexually transmitted disease in women
    Chris L McGowin
    Department of Medicine, Section of Infectious Diseases, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS Pathog 7:e1001324. 2011
    ..Collectively, M. genitalium is highly prevalent in high- and low-risk populations, and should be considered an etiologic agent of select reproductive tract disease syndromes in women...
  22. pmc Clinical presentation of Mycoplasma genitalium Infection versus Neisseria gonorrhoeae infection among women with pelvic inflammatory disease
    Vanessa L Short
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 48:41-7. 2009
    ..The characteristics of nongonococcal, nonchlamydial PID have not been well described. Our objective was to examine the characteristics of Mycoplasma genitalium infection among women with clinically suspected PID...
  23. ncbi Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study
    E Jernberg
    Olafiaklinikken STD Clinic, Grensen 5 7, 0159 Oslo, Norway
    Int J STD AIDS 19:676-9. 2008
    ..Azithromycin 1 g as a single dose seems to be the best choice of treatment for M. genitalium, with moxifloxacin 400 mg x 1 for seven days if treatment fails...
  24. ncbi Mycoplasma genitalium in asymptomatic patients: implications for screening
    J D C Ross
    Whittall Street Clinic, Whittall Street, Birmingham B4 6DH, UK
    Sex Transm Infect 85:436-7. 2009
    ..The objective of this study was to measure the positivity rate of M genitalium infection in asymptomatic individuals presenting to a sexual-health clinic to inform the need for screening in this population...
  25. pmc A serological study of the role of Mycoplasma genitalium in pelvic inflammatory disease and ectopic pregnancy
    Margaretha Jurstrand
    Clinical Research Centre, University Hospital, SE 70185 Orebro, Sweden
    Sex Transm Infect 83:319-23. 2007
    ..The aim of this study was to evaluate the association between M genitalium antibodies and pelvic inflammatory disease (PID) and ectopic pregnancy (EP) using a lipid-associated membrane protein-enzyme immunoassay (LAMP-EIA) method...
  26. ncbi Hemotrophic mycoplasmas induce programmed cell death in red blood cells
    Kathrin M Felder
    Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Cell Physiol Biochem 27:557-64. 2011
    ..suis is able to induce eryptotic processes it is concluded that eryptosis is one anemia-inducing factor during M. suis infections and, therefore, plays a significant role in the pathogenesis of infectious anemia due to HM infection...
  27. ncbi Mycoplasma genitalium: the aetiological agent of urethritis and other sexually transmitted diseases
    Jørgen Skov Jensen
    Mycoplasma Laboratory, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    J Eur Acad Dermatol Venereol 18:1-11. 2004
    ..The optimal treatment of M. genitalium infections remains to be determined, but antibiotics of the macrolide group appear to be more active than tetracyclines...
  28. ncbi Association of Mycoplasma genitalium and HIV infection: a systematic review and meta-analysis
    Sue Napierala Mavedzenge
    Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    AIDS 23:611-20. 2009
    ..To systematically review studies of Mycoplasma genitalium and the association with HIV infection in adults and to summarize the findings in a meta-analysis...
  29. ncbi The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)
    Leka Papazisi
    Center of Excellence for Vaccine Research, The University of Connecticut, Storrs, CT 06269 3089, USA
    Microbiology 149:2307-16. 2003
    ..The completion of this sequence has spawned multiple projects directed at defining the biological basis of M. gallisepticum...
  30. ncbi Proteomic survey of the pathogenic Mycoplasma hyopneumoniae strain 7448 and identification of novel post-translationally modified and antigenic proteins
    Paulo Marcos Pinto
    Laboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, UFRGS, Porto Alegre, RS, Brazil
    Vet Microbiol 121:83-93. 2007
    ..The now available proteome map is expected to serve as a reference for comparative analyses between M. hyopneumoniae pathogenic and non-pathogenic strains, and for methabolic studies based on cells cultured under modified conditions...
  31. pmc Mycoplasmas and oncogenesis: persistent infection and multistage malignant transformation
    S Tsai
    American Registry of Pathology, Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Proc Natl Acad Sci U S A 92:10197-201. 1995
    ..Mycoplasma-mediated multistage oncogenesis exhibited here shares many characteristics found in the development of human cancer...
  32. ncbi [Systematic screening tests for Chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum in urogenital specimens of infertile couples]
    A Rosemond
    Service de Bacteriologie Virologie, Hopital Bretonneau, CHRU de Tours, 37044 Tours Cedex, France
    Pathol Biol (Paris) 54:125-9. 2006
    ..In addition, an important modification of vaginal flora was observed in 12% of cases, and 2 vaginosis were diagnosed; the putative consequences of this disequilibrium has to be further investigated...
  33. ncbi Mycoplasma synoviae invades non-phagocytic chicken cells in vitro
    Daliborka Dusanic
    Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230 Domzale, Slovenia
    Vet Microbiol 138:114-9. 2009
    ..2+/-0.3%) similar to that of R(low) (1.1+/-0.1%). This is the first study documenting the invasiveness of M. synoviae strains for non-phagocytic chicken cells...
  34. ncbi Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes
    Kyung Joon Oh
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Am J Obstet Gynecol 203:211.e1-8. 2010
    ..The objective of the study was to compare the intensity of inflammatory responses between intraamniotic infection with genital mycoplasmas and intraamniotic infection with other microorganisms...
  35. pmc Genome of Mycoplasma haemofelis, unraveling its strategies for survival and persistence
    Andrea P Santos
    Department of Comparative Pathobiology, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA
    Vet Res 42:102. 2011
    ..haemofelis infection. Further, it will provide new insights into its pathogenicity and clues needed to formulate media to support the in vitro cultivation of M. haemofelis...
  36. pmc Phylogeny-based rapid identification of mycoplasmas and ureaplasmas from urethritis patients
    Takashi Yoshida
    Infectious Disease Laboratory, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, Shimura 3 30 1, Itabashi, Tokyo 174 8555, Japan
    J Clin Microbiol 40:105-10. 2002
    ..genitalium and U. urealyticum. This phylogeny-based identification of mycoplasmas and ureaplasmas provides not only a powerful tool for rapid diagnosis but also the basis for etiological studies of these pathogens...
  37. pmc Mycoplasmas: sophisticated, reemerging, and burdened by their notoriety
    J B Baseman
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758, USA
    Emerg Infect Dis 3:21-32. 1997
    ..In this review, we highlight the biology and pathogenesis of these procaryotes and provide new evidence that may lead to increased appreciation of their role as human pathogens...
  38. ncbi Prevalence of selected infectious disease agents in cats from Arizona
    Jason M Eberhardt
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA
    J Feline Med Surg 8:164-8. 2006
    ..The Bartonella species and hemoplasma results suggest flea control should be maintained...
  39. pmc Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium
    S Dhandayuthapani
    Department of Microbiology, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Bacteriol 183:5645-50. 2001
    ..genitalium. These results indicate that MsrA plays an important role in M. genitalium pathogenicity, possibly by protecting mycoplasma protein structures from oxidative damage or through alternate virulence-related pathways...
  40. ncbi Susceptibility of alpine ibex to conjunctivitis caused by inoculation of a sheep-strain of Mycoplasma conjunctivae
    M Giacometti
    Institute of Animal Pathology, University of Berne, Switzerland
    Vet Microbiol 61:279-88. 1998
    ..Our investigation indicates that sheep-strains of M. conjunctivae can induce conjunctivitis in alpine ibex, thus showing pathogenicity of this organism for Caprinae species other than domestic sheep and goats...
  41. pmc Mycoplasma hyorhinis infection in gastric carcinoma and its effects on the malignant phenotypes of gastric cancer cells
    Hua Yang
    Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing, PR China
    BMC Gastroenterol 10:132. 2010
    ..Mycoplasma hyorhinis infection has been postulated to play a role in the development of several types of cancer, but the direct evidence and mechanism remained to be determined...
  42. pmc Molecular characterization of the uncultivatable hemotropic bacterium Mycoplasma haemofelis
    Emily N Barker
    School of Veterinary Sciences, University of Bristol, Langford, BS40 5DU, UK
    Vet Res 42:83. 2011
    ..A number of immunogenic proteins, and a potential mechanism for host immune system evasion, have been identified...
  43. ncbi Quantification of the humoral immune response and hemoplasma blood and tissue loads in cats coinfected with 'Candidatus Mycoplasma haemominutum' and feline leukemia virus
    Godelind A Wolf-Jäckel
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Microb Pathog 53:74-80. 2012
    ..The tissue loads appeared to correlate with the duration of infection and with the blood loads, but no evidence of significant CMhm tissue sequestration was found...
  44. ncbi Microbiological survey for Mycoplasma spp. in a contagious agalactia endemic area
    C de la Fe
    Unit of Epidemiology and Preventive Medicine, Veterinary Faculty, University of Las Palmas, Trasmontaña s n 35416 Arucas, Gran Canaria, Spain
    Vet J 170:257-9. 2005
    ....
  45. ncbi Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Semin Fetal Neonatal Med 14:190-9. 2009
    ....
  46. ncbi Fatal outcome of a disseminated dual infection with drug-resistant Mycoplasma hominis and Ureaplasma parvum originating from a septic arthritis in an immunocompromised patient
    Colin R Mackenzie
    Institute of Medical Microbiology and Hospital Hygiene, University Hospital, Heinrich Heine University, Universitätsstraße 1, Dusseldorf, Germany
    Int J Infect Dis 14:e307-9. 2010
    ..This may be of increasing importance as illustrated in the case below...
  47. ncbi Prevalence and correlates of Mycoplasma genitalium infection among female sex workers in Kampala, Uganda
    Judith Vandepitte
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    J Infect Dis 205:289-96. 2012
    ..We assessed the prevalence and explored determinants of this emerging sexually transmitted infection (STI) in high-risk women in Uganda...
  48. ncbi Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella, and human papillomavirus in Japanese men with urethritis, and risk factors for detection of urethral human papillomavirus infection
    Kazuyoshi Shigehara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1, Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    J Infect Chemother 17:487-92. 2011
    ..85 (95% CI 1.49-9.94) and 2.41 (95% CI 1.03-5.61), respectively. It is likely that urethral HPV detection is associated with current sexual activity and the presence of N. gonorrhoeae, C. trachomatis, and/or M. genitalium infections...
  49. ncbi Prevalence and geographical distribution of canine hemotropic mycoplasma infections in Mediterranean countries and analysis of risk factors for infection
    Marilisa Novacco
    Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Vet Microbiol 142:276-84. 2010
    ..The climate and living conditions seemed to influence canine hemoplasma prevalence. The clinical importance of canine hemoplasma infections appeared to be low, but the infection stage of the presented dogs was unknown...
  50. ncbi mgpB and mgpC sequence diversity in Mycoplasma genitalium is generated by segmental reciprocal recombination with repetitive chromosomal sequences
    Stefanie L Iverson-Cabral
    Department of Pathobiology, University of Washington, Seattle, WA 98104, USA
    Mol Microbiol 66:55-73. 2007
    ..genitalium by the mutual exchange of sequences makes this organism unique among bacterial pathogens...
  51. ncbi Genital mycoplasmas, including Mycoplasma genitalium, as sexually transmitted agents
    Anneli Uuskula
    Clinic of Dermatovenereology, University of Tartu, Estonia
    Int J STD AIDS 13:79-85. 2002
    ..genitalium in the female genital tract. Evidence-based data are needed to decide whether current non-gonococcal infection treatment principles are applicable or not for M. genitalium infections...
  52. ncbi A specific PCR for the detection of Mycoplasma putrefaciens, one of the agents of the contagious agalactia syndrome of goats
    A Peyraud
    CIRAD EMVT Sante Animale, Animal Health Program, TA30 G Campus International de Baillarguet, 34398 Montpellier, France
    Mol Cell Probes 17:289-94. 2003
    ..This new PCR technique will be very useful for a quicker determination of M. putrefaciens strains as well as a better understanding of the prevalence of M. putrefaciens infections...
  53. ncbi First LightCycler real-time PCR assay for the quantitative detection of Mycoplasma suis in clinical samples
    Ludwig E Hoelzle
    Institute of Veterinary Bacteriology, Vetsuisse Faculty, University Zurich, Winterthurerstr 270, 8057 Zurich, Switzerland
    J Microbiol Methods 70:346-54. 2007
    ..In conclusion, this new LC MSG1 PCR assay represents a powerful tool for the improvement of the current M. suis diagnosis and for prevalence and pathogenesis studies...
  54. pmc Investigation of human haemotropic Mycoplasma infections using a novel generic haemoplasma qPCR assay on blood samples and blood smears
    Severine Tasker
    School of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, UK
    J Med Microbiol 59:1285-92. 2010
    ..This report describes novel extraction and qPCR methodologies for haemoplasma screening. Previously reported human haemoplasmosis based on cytological diagnosis alone should be viewed with caution...
  55. ncbi Mycoplasma testing of cell substrates and biologics: Review of alternative non-microbiological techniques
    Dmitriy V Volokhov
    U S Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccine Research and Review, Division of Viral Products, Laboratory of Methods Development, HFM 470, 1401 Rockville Pike, Rockville, MD 20852, USA
    Mol Cell Probes 25:69-77. 2011
    ..g. from inactivated raw materials, etc.). Our review provides an overview of these alternative methods and discusses the pros and cons of their application for the testing of mycoplasmas in biologics and cell substrates...
  56. ncbi Risk factors associated with Mycoplasma agalactiae infection of small ruminants in northern Jordan
    Waleed Al-Momani
    University of Nizwa, Barkat Al Mauz, Nizwa, Oman
    Prev Vet Med 83:1-10. 2008
    ..04) with M. agalactiae seropositivity. Educating small ruminant farmers to avoid the use of outsider rams, ensuring adequate cleaning of milking utensils and separating the young from dams would enhance the health of small ruminants...
  57. ncbi Infectious keratoconjunctivitis in bighorn sheep, Silver Bell Mountains, Arizona, USA
    Brian D Jansen
    325 Biological Sciences East Building, School of Natural Resources, University of Arizona, Tucson, Arizona 85721, USA
    J Wildl Dis 42:407-11. 2006
    ..4 days. Given the clear potential for disease transmission to bighorn sheep, we recommend that land managers not allow the pasturing of domestic goats near occupied bighorn sheep habitat...
  58. ncbi Serological study of contagious agalactia in herds of goats in the Canary Islands
    P Assunção
    Unit of Epidemiology and Preventive Medicine, Veterinary Faculty, University of Las Palmas, Transmontaña s n 35416 Arucas, Las Palmas de Gran Canaria, Spain
    Vet Rec 154:684-7. 2004
    ..The results indicated that the seroprevalence of both organisms is high on all the islands; average values of 55 per cent and 67 per cent were recorded, respectively, for M agalactiae and MmmLC...
  59. pmc Development of a quantitative real-time PCR assay for detection of Mycoplasma genitalium
    Helle Friis Svenstrup
    Department of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 43:3121-8. 2005
    ..9 copies/microl, respectively [P = 0.0005]). This assay may prove useful in the monitoring of treatment and for optimizing sample preparation methods...
  60. pmc Persistence of Mycoplasma genitalium following azithromycin therapy
    Catriona S Bradshaw
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
    PLoS ONE 3:e3618. 2008
    ..To determine clinical outcomes and cure rates for M.genitalium genital infection in men and women following azithromycin 1 g...
  61. pmc Mycoplasma genitalium presence, resistance and epidemiology in Greenland
    Dionne C Gesink
    Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    Int J Circumpolar Health 71:1-8. 2012
    ..Greenland reports the highest rates of chlamydial infection and gonorrhea in the Arctic. Our objective was to determine the presence, and describe the basic epidemiology, of Mycoplasma genitalium for Greenland...
  62. ncbi Mycoplasmas associated with canine infectious respiratory disease
    Victoria J Chalker
    Department of Pathology and Infectious Diseases, Royal Veterinary College RVC, University of London, Hawkshead Lane, North Mymms AL9 7TA, UK
    Microbiology 150:3491-7. 2004
    ..Isolation of M. cynos was correlated with an increased severity of CIRD, younger age and a longer time in the kennel...
  63. ncbi Common garden experiment reveals pathogen isolate but no host genetic diversity effect on the dynamics of an emerging wildlife disease
    D M Hawley
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    J Evol Biol 23:1680-8. 2010
    ..Our results indicate that contemporary differences in host genetic diversity likely do not explain the lower conjunctivitis prevalence in native house finches, but isolate-level differences in virulence may play an important role...
  64. pmc Cytokine and chemokine transcription profile during Mycoplasma pulmonis infection in susceptible and resistant strains of mice: macrophage inflammatory protein 1beta (CCL4) and monocyte chemoattractant protein 2 (CCL8) and accumulation of CCR5+ Th cells
    Xiangle Sun
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Infect Immun 74:5943-54. 2006
    ..Thus, there was a significant cytokine response associated with disease pathogenesis, and these studies provide important leads and insights into ongoing cytokine- and chemokine-mediated processes in this persistent inflammatory disease...
  65. ncbi Prevalence of Mycoplasma suis (Eperythrozoon suis) infection in swine and swine-farm workers in Shanghai, China
    Cong L Yuan
    School of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Medicine, Shanghai Jiaotong University, Shanghai 200240, People s Republic of China
    Am J Vet Res 70:890-4. 2009
    ..To determine the prevalence of Mycoplasma suis infection in swine, swine-farm workers, and swine veterinarians in Shanghai, China...
  66. ncbi Mycoplasma infection suppresses p53, activates NF-kappaB and cooperates with oncogenic Ras in rodent fibroblast transformation
    D Y Logunov
    Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia
    Oncogene 27:4521-31. 2008
    ....
  67. ncbi 'Candidatus Mycoplasma haematoparvum', a novel small haemotropic mycoplasma from a dog
    Jane E Sykes
    Department of Medicine and Epidemiology, University of California, Davis, CA 95616, USA
    Int J Syst Evol Microbiol 55:27-30. 2005
    ..As this organism has not been cultured in vitro, the candidate species name 'Candidatus Mycoplasma haematoparvum' is proposed...
  68. pmc Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection
    L Falk
    Department of Dermatology and Venereology, University Hospital, Orebro, SE 701 85 Orebro, Sweden
    Sex Transm Infect 81:73-8. 2005
    ....
  69. pmc Comparison of two Mycoplasma genitalium real-time PCR detection methodologies
    Jimmy Twin
    Department of Microbiology and Infectious Diseases, The Royal Women s Hospital, Melbourne, Australia
    J Clin Microbiol 49:1140-2. 2011
    ..97 (95% confidence interval [CI], 0.94 to 1.01) and no difference in bacterial load quantified (P = 0.4399)...
  70. pmc Microbial correlates of delayed care for pelvic inflammatory disease
    Brandie D Taylor
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sex Transm Dis 38:434-8. 2011
    ..We studied the microbial correlates of time to care and long-term outcomes among pelvic inflammatory disease (PID) patients, as delayed care may increase the risk for reproductive sequelae...
  71. ncbi Mycoplasma bovis pneumonia in cattle
    Jeff L Caswell
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Anim Health Res Rev 8:161-86. 2007
    ..bovis infection in the bovine respiratory tract...
  72. ncbi Use of a novel real-time PCR technique to monitor and quantitate Mycoplasma bovis infection in cattle herds with mastitis and respiratory disease
    Konrad Sachse
    Institute of Molecular Pathogenesis, Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Jena, Germany
    Vet J 186:299-303. 2010
    ..This novel real-time PCR assay is specific for M. bovis and can detect bacterial loads as low as 100 colony forming units/mL of milk...
  73. ncbi Mycoplasma infections in small ruminants
    D C Ruffin
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn University, Alabama, USA
    Vet Clin North Am Food Anim Pract 17:315-32, vi-vii. 2001
    ..This article provides a review of the pathogenesis, clinical signs, and treatment options for common disease syndromes involving Mycoplasma spp. in small ruminants...
  74. pmc Mycoplasma genitalium rapidly disseminates to the upper reproductive tracts and knees of female mice following vaginal inoculation
    Chris L McGowin
    Department of Pediatrics, 3 206 Mary Moody Northen Pavilion, L22486, 301 University Blvd, Galveston, TX 77555 0436, USA
    Infect Immun 78:726-36. 2010
    ..These findings provide strong experimental evidence that M. genitalium can establish long-term infection of reproductive tract and joint tissues, with preliminary evidence of pathological reproductive tract outcomes...
  75. pmc Failure of cefoxitin and doxycycline to eradicate endometrial Mycoplasma genitalium and the consequence for clinical cure of pelvic inflammatory disease
    C L Haggerty
    University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, 516B Parran Hall, Pittsburgh, PA 15261, USA
    Sex Transm Infect 84:338-42. 2008
    ..As Mycoplasma genitalium is associated with pelvic inflammatory disease (PID), we examined the efficacy of a commonly used PID antimicrobial in treating M genitalium upper genital tract infection...
  76. ncbi Mycoplasma genitalium in women with lower genital tract inflammation
    H Moi
    Olafia, Medical Division, Rikshospitalet University Hospital and University of Oslo, Medical Faculty, Oslo, Norway
    Sex Transm Infect 85:10-4. 2009
    ....
  77. ncbi Mycoplasma genitalium, Chlamydia trachomatis, and tubal factor infertility--a prospective study
    Helle Friis Svenstrup
    Institute of Medical Microbiology and Immunology, University of Aarhus, Arhus, Denmark
    Fertil Steril 90:513-20. 2008
    ..To determine the presence of M. genitalium and C. trachomatis in women attending fertility clinics and to follow these women for the effects of previous infections or tubal damage on pregnancy rate and outcome...
  78. pmc Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women
    Jill S Huppert
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center Cincinnati, Ohio 45229 3039, USA
    Sex Transm Dis 35:250-4. 2008
    ....
  79. ncbi Mycoplasma genitalium symptoms, concordance and treatment in high-risk sexual dyads
    A R Thurman
    Department of Obstetrics and Gynaecology, Eastern Virginia School of Medicine, CONRAD Clinical Research Center, Norfolk, VA 23507, USA
    Int J STD AIDS 21:177-83. 2010
    ..MG was associated with current urethral discharge in men. No clinical symptoms were specifically diagnostic of MG infection in women...
  80. ncbi Occurrence of Mycoplasma genitalium in fertile and infertile women
    Joanna Grześko
    Gynecology Clinic, 2nd Department of Gynecology and Obstetrics, Wroclaw Medical University, Wrocław, Poland
    Fertil Steril 91:2376-80. 2009
    ..To determine the frequency of occurrence of Mycoplasma genitalium in the reproductive organs of infertile women in comparison with a control group of healthy, fertile women...
  81. ncbi Management of women with cervicitis
    Jeanne M Marrazzo
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Infect Dis 44:S102-10. 2007
    ....
  82. pmc In vivo transmission studies of 'Candidatus Mycoplasma turicensis' in the domestic cat
    Kristina Museux
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Switzerland
    Vet Res 40:45. 2009
    ..In conclusion, CMt transmission by social contact seems less likely than transmission by aggressive interaction. The latter transmission may occur if the recipient cat is exposed to blood from an infected cat...
  83. pmc Mycoplasma genitalium among adolescent women and their partners
    Aneesh K Tosh
    Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Adolesc Health 40:412-7. 2007
    ..In this longitudinal study, the epidemiology, natural history, and associated clinical findings of M. genitalium among adolescents in a primary care setting were explored...
  84. ncbi Phase and antigenic variation in mycoplasmas
    Christine Citti
    INRA, UMR 1225, F 31076 Toulouse, France
    Future Microbiol 5:1073-85. 2010
    ....
  85. ncbi Differentiation of Haemobartonella canis and Mycoplasma haemofelis on the basis of comparative analysis of gene sequences
    Adam J Birkenheuer
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606 1428, USA
    Am J Vet Res 63:1385-8. 2002
    ..To determine whether Haemobartonella canis and Mycoplasma haemofelis (formerly known as H felis [large form]) can be differentiated by use of comparative analysis of gene sequences...
  86. ncbi Pathogenicity of Mycoplasma synoviae in broiler chickens
    S B Lockaby
    Department of Veterinary Pathobiology, Auburn University, AL 36849, USA
    Vet Pathol 35:178-90. 1998
    ..These results are useful in comparative evaluations of the virulence of other M. synoviae isolates and form a basis for characterization of virulence factors of M. synoviae...
  87. pmc Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline
    A Wikstrom
    Karolinska University Hospital, Solna, Karolinska Institutet, Department of Dermatovenereology, SE 171 76 Stockholm, Sweden
    Sex Transm Infect 82:276-9. 2006
    ..The aim of this study was to determine the importance of Mycoplasma genitalium in this condition and to monitor the effect of treatment with macrolides...
  88. ncbi Mycoplasma genitalium infection and persistence in a cohort of female sex workers in Nairobi, Kenya
    Craig R Cohen
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, CA, USA
    Sex Transm Dis 34:274-9. 2007
    ..The objective of this study was to assess the risk factors for and persistence of Mycoplasma genitalium (MG) in a highly exposed female population in Kenya...
  89. ncbi Surface localized glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma genitalium binds mucin
    René A Alvarez
    Department of Microbiology and Immunology, 7703 Floyd Curl Drive, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Mol Microbiol 48:1417-25. 2003
    ..The role of GAPDH as an adhesin to Mn not only provides insights into the organism's mechanisms of adherence and colonization but also into its ability to maximize its limited genome...
  90. pmc Mycoplasma genitalium: prevalence and behavioural risk factors in the general population
    Berit Andersen
    Research Unit for General Practice, Vennelyst Boulevard 6, DK 8000 Aarhus C, Denmark
    Sex Transm Infect 83:237-41. 2007
    ..Mycoplasma genitalium has been shown to cause urethritis in men and cervicitis in women and may also be a causative agent in female infertility...
  91. ncbi Prevalence of Bartonella species, haemoplasma species, Ehrlichia species, Anaplasma phagocytophilum, and Neorickettsia risticii DNA in the blood of cats and their fleas in the United States
    Michael R Lappin
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    J Feline Med Surg 8:85-90. 2006
    ..9%) and their fleas (65.2%). Results of this study support the recommendation to maintain flea control on cats in endemic areas...
  92. ncbi Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial
    E Björnelius
    Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Sex Transm Infect 84:72-6. 2008
    ..To evaluate the microbiological cure rate after treatment with tetracyclines or azithromycin in patients infected with M genitalium...
  93. ncbi Mycoplasma infections and different human carcinomas
    S Huang
    Department of Biochemistry and Molecular Biology, Beijing Institute for Cancer Research and Peking University School of Oncology No 1 Da Hong Luo Chang Street, Western District, Beijing 100034, China
    World J Gastroenterol 7:266-9. 2001
    ..To explore relationships between human carcinomas and mycoplasma infection...
  94. pmc Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5' nuclease real-time PCR
    Ryoichi Hamasuna
    Mycoplasma Laboratory, Statens Serum Institut, Copenhagen S, Denmark
    Antimicrob Agents Chemother 49:4993-8. 2005
    ..MICs for tetracycline ranged from 0.125 to 4 mg/liter. This new method could increase the number of M. genitalium strains available for antibiotic susceptibility testing and significantly shorten the time from sampling to MIC results...
  95. ncbi Presence of Mycoplasma haemofelis, Mycoplasma haemominutum and piroplasmids in cats from southern Europe: a molecular study
    A Criado-Fornelio
    Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Alcala de Henares, 28871, Alcala de Henares, Spain
    Vet Microbiol 93:307-17. 2003
    ..canis canis, 1 with Theileria annae, and 1 with B. canis canis and T. annae both)...
  96. ncbi Cervicitis and genitourinary symptoms in women culture positive for Mycoplasma genitalium
    Jeffrey E Korte
    Department of Obstetrics and Gynecology, School of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Reprod Immunol 55:265-75. 2006
    ..Mycoplasma genitalium has been associated with male urethritis. We sought to relate M. genitalium to genitourinary signs and symptoms in women...
  97. pmc Mycoplasma genitalium: an organism commonly associated with cervicitis among west African sex workers
    J Pepin
    Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Canada
    Sex Transm Infect 81:67-72. 2005
    ..To identify the contribution of Mycoplasma genitalium to the aetiology of cervicitis in sub-Saharan Africa and its relative importance in the overall burden of sexually transmitted infections among female sex workers (FSW)...
  98. ncbi Mycoplasma disease and acute chest syndrome in sickle cell disease
    Lynne Neumayr
    Hematology Oncology Department, Children s Hospital Oakland, Oakland, California 94609, USA
    Pediatrics 112:87-95. 2003
    ..The National Acute Chest Syndrome Study Group was designed to identify the etiologic agents and clinical outcomes associated with this syndrome...
  99. pmc Invasion of bovine peripheral blood mononuclear cells and erythrocytes by Mycoplasma bovis
    Jacques van der Merwe
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Infect Immun 78:4570-8. 2010
    ..The invasion of circulating immune cells and erythrocytes could play an important role in disease pathogenesis by aiding the transport of M. bovis from the lungs to other sites...
  100. ncbi Guidelines and recommendations for antimicrobial minimum inhibitory concentration (MIC) testing against veterinary mycoplasma species. International Research Programme on Comparative Mycoplasmology
    P C Hannan
    Mycoplasma Experience Ltd, Reigate, Surrey, UK
    Vet Res 31:373-95. 2000
    ..Methods for assessing mycoplasmacidal (MMC) activity of antimicrobial agents are also described. Adoption of these guidelines should lead to more consistent MIC results being obtained between laboratories...
  101. pmc Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens--a randomized clinical trial
    J R Schwebke
    University of Alabama at Birmingham, 703 19th St South, Birmingham, AL 35294 0007, USA
    Clin Infect Dis 52:163-70. 2011
    ..A secondary aim was to compare the efficacy of doxycycline therapy and with that of azithromycin therapy...

Research Grants41

  1. BIOLOGY AND PATHOGENICITY OF MYCOPLASMA GENITALIUM
    Joel Baseman; Fiscal Year: 2007
    ..It is our expectation that the proposed studies will significantly increase our understanding of mycoplasma pathogenicity and advance new therapeutic strategies to control mycoplasma infections and disease progression.
  2. CYTOKINE INDUCTION BY A 48 KD MYCOPLASMA GENE PRODUCT
    Robert Hall; Fiscal Year: 1999
    ..CHO cells P48 is an important immunomodulatory molecule which may be important in the pathophysiology of Mycoplasma infections and may be useful in dissecting the mechanisms involved in mammalian hematopoietic cell differentiation ..
  3. MYCOPLASMA INFECTIONS AND CHILDHOOD ASTHMA
    T Atkinson; Fiscal Year: 2002
    ..Finally, I plan to investigate the effects of infection in a mouse model of asthma, which will permit the use of deletional mutant strains in the investigation of pathogenic mechanisms. ..
  4. Annotation of the Mycoplasma alligatoris genome
    Daniel Brown; Fiscal Year: 2002
    ..The ease of PCR-based cloning and the accessibility of bioinformatics software make this an ideal project to engage undergraduate students in innovative biomedical research. ..
  5. Mycoplasma Genitalium and Pelvic Inflammatory Disease
    Catherine Haggerty; Fiscal Year: 2007
    ..Exploring the role of M. genitalium in PID is imperative to optimize diagnosis and treatment and prevent reproductive morbidity among women with nongonococcal/nonchlamydial PID. ..
  6. Ureaplasmas in acute and persistent urethritis: clinical implications
    Lisa E Manhart; Fiscal Year: 2010
    ..The results of this study may lead to the identification of an additional cause of this syndrome, provide guidance on treatment decisions, and shed light on the etiology of persistent and recurrent cases. ..
  7. Infection, Inflammation and Preeclampsia
    Catherine Haggerty; Fiscal Year: 2009
    ..Finally, cytokine and CRP testing may prove to be effective tools for identifying women at risk for developing preeclampsia. ..
  8. Molecular Epidemiology, Virulence, and Genomic Characterization of Ureaplasmas
    Ken B Waites; Fiscal Year: 2010
    ....
  9. Urinary Symptoms in Adolescent Females: STI or UTI?
    Jill Huppert; Fiscal Year: 2004
    ..The findings of this study will strengthen the evidence base for symptom-based STI testing of SA adolescent females and will promote care that addresses both individual patient and public health needs. ..
  10. COMPARATIVE MEDICAL SCIENTIST POSTDOCTORAL TRAINING
    Trenton Schoeb; Fiscal Year: 2006
    ..abstract_text> ..
  11. Tinidazole for the Treatment of Bacterial Vaginosis
    Jane Schwebke; Fiscal Year: 2007
    ..In addition, we will measure vaginal and serum concentrations of drug during treatment and correlate with cure rates, short-term recurrence of BV, and severity of infection. ..
  12. Cell-FIV: Mucosal transmission and intervention
    MARY BURKHARD; Fiscal Year: 2005
    ..Vaginal challenge with cell-associated FIV will test the correlates of protection. ..
  13. Hemolysin and Immunobiology of Chancroid
    Patricia Totten; Fiscal Year: 2004
    ..ducreyi hemolysin in the pathogenesis and immunobiology of chancroid and will provide a groundwork on which to base future strategies for vaccine development for chancroid. ..
  14. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    Samuel Cartner; Fiscal Year: 2008
    ..The requested equipment will be a part of the infrastructure needed to maintain and support the growth of a nationally and internationally recognized interdisciplinary research program. [unreadable] [unreadable] [unreadable]..
  15. ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONS
    Richard Martin; Fiscal Year: 2003
    ....
  16. Alloantigen exposure influences infection threshold
    MARY BURKHARD; Fiscal Year: 2006
    ..Because these therapies would work in a virus non-specific manner, they would have potential use at the population level against multiple virus subtypes. ..
  17. Therapy and Prevention for Bacterial Vaginosis
    Jane Schwebke; Fiscal Year: 2006
    ..We will also utilize specimens from these prospective studies to further study the association of Mobiluncus, an organism strongly associated with BV using sensitive PCR technology. ..
  18. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2006
    ....
  19. Innate Immunity and RSV Infection in Children
    Theresa Guilbert; Fiscal Year: 2007
    ..Accomplishment of these aims will allow us to begin to elucidate the immune mechanisms of the major gene-environment interactions influencing early childhood respiratory disease. ..
  20. MODULATORS OF P53 EXPRESSION AND FUNCTION
    Andrei Gudkov; Fiscal Year: 2007
    ..Aim 4 addresses the safety concerns related to the p53 inhibitory approach and will result in estimation of a potential risk of carcinogenic effects of different classes of p53 inhibitors. ..
  21. GENETIC ELEMENTS TRANSFORMING MOUSE FIBROBLASTS
    Andrei Gudkov; Fiscal Year: 2009
    ..The success of the proposed study will indicate development of a powerful target discovery tool that will be applicable for ACTT identification in other types of cancer. ..
  22. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    Samuel Cartner; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  23. MYCOPLASMA SUPERANTIGEN MAM IN DISEASE AND AUTOIMMUNITY
    Hong Hua Mu; Fiscal Year: 2003
    ..Specifically the investigator shall define the role played by SAg-induced cytokines and protection against disease using the MAM vaccines described earlier. ..
  24. CELL ASSOCIATED FIV--VAGINAL TRANSMISSION AND PROTECTION
    MARY BURKHARD; Fiscal Year: 2003
    ..Vaginal challenge with cell-associated FIV will test the correlates of protection. ..
  25. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Richard Martin; Fiscal Year: 2002
    ....
  26. Control of Trichomoniasis -A Paradigm for STD Control
    Jane Schwebke; Fiscal Year: 2006
    ..vaginalis, to examine strain differences using PFGE, and to examine the prevalence of resistance strains and their potential contribution to treatment failure. ..
  27. MOLECULAR MECHANISMS OF EIAV PERSISTENCE
    JERALD OAKS; Fiscal Year: 2001
    ..These studies will provide insight into HIV persistence in HAART patients, and potentially provide a model that can be used to evaluate strategies for actual elimination of lentiviral infections. ..
  28. MYCOPLASMA PNEUMONIAE - AIRWAY INTERPLAY
    Joel Baseman; Fiscal Year: 2004
    ..Ultimately, these studies should identify new therapeutic strategies to control mycoplasma infections in humans.
  29. Novel Integrative Genetic Elements of Mycoplasmas
    Michael Calcutt; Fiscal Year: 2003
    ....
  30. Clinical Epidemiology of Mycoplasma genitalium
    Patricia Totten; Fiscal Year: 2006
    ..Studies of its association with salpingitis and pregnancy morbidity are essential. Future studies should also address whether, similar to gonorrhea and chlamydial infection, it facilitates transmission of HIV infection. ..
  31. Mycoplasma Superantigen & RA MHC Susceptibility Alleles
    BARRY COLE; Fiscal Year: 2006
    ..arthritidis in these "humanized" mice and determine strategies to overcome the effect of the superantigen MAM in initiating disease pathogenesis by modification of the cytokine milieu. ..
  32. Innovative Investigations and Therapies for Asthma
    Richard Martin; Fiscal Year: 2007
    ..The ability to predict who will and will not respond to corticosteroids and additive therapy will greatly improve our ability to treat asthma effectively. ..
  33. Concordance Rates of Mobiluncus Among Sexual Partners
    Jane Schwebke; Fiscal Year: 2004
    ..Our hypothesis is that Mobiluncus curtisii is important in the pathogenesis of BV and high concordance rates among sexual partners will be found suggesting sexual transmission. ..
  34. PATHOGENIC MECHANISMS IN UTI
    Walter Stamm; Fiscal Year: 2007
    ..Face Page .................................................................................................. 1 B. Description, ..
  35. Molecular Epidemiology and Virulence of URTD
    Lori Wendland; Fiscal Year: 2008
    ..abstract_text> ..
  36. Gene Polymorphisms, Preterm Birth, Neonatal Complicatio*
    Steven Witkin; Fiscal Year: 2005
    ..Identification of genetic factors in mothers or their neonates that influence susceptibility to preterm labor and fetal morbidity in different racial groups will aid in development of improved protocols for monitoring and treatment...
  37. The Acquisition of Bacterial Vaginosis in Lesbians
    Jeanne Marrazzo; Fiscal Year: 2006
    ..Lesbian couples provide a unique opportunity to conduct comparative studies of vaginal microbial ecology in sex partners, and to directly analyze determinants of transmission. ..
  38. Particulate Matter/Mycoplasma Stress Interactions
    James Fabisiak; Fiscal Year: 2008
    ..abstract_text> ..
  39. The Effect of Mycoplasma on Chronic Asthma
    Richard Martin; Fiscal Year: 2008
    ..pneumoniae and asthma will be obtained through this PPG and will ultimately give new knowledge to the understanding of asthma pathophysiology and potential future novel therapies. ..