listeria infections

Summary

Summary: Infections with bacteria of the genus LISTERIA.

Top Publications

  1. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
  2. pmc Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
  3. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
  4. ncbi Impaired immune and acute-phase responses in interleukin-6-deficient mice
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Nature 368:339-42. 1994
  5. ncbi Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    Koichi S Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 307:731-4. 2005
  6. ncbi Listeria: A foodborne pathogen that knows how to survive
    Megha Gandhi
    Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Int J Food Microbiol 113:1-15. 2007
  7. doi The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    Yun Gi Kim
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 28:246-57. 2008
  8. ncbi Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection
    C Pope
    Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 166:3402-9. 2001
  9. pmc Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
  10. ncbi Exposure of Listeria monocytogenes within an epidemic caused by butter in Finland
    R Maijala
    Risk Analysis, National Veterinary and Food Research Institute, Helsinki, Finland
    Int J Food Microbiol 70:97-109. 2001

Research Grants

  1. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
  2. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen Gregory; Fiscal Year: 2007
  3. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen Gregory; Fiscal Year: 2009
  4. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen H Gregory; Fiscal Year: 2010
  5. FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATION
    Stephen Gregory; Fiscal Year: 2004
  6. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2006
  7. Immunity to Intracellular Pathogens
    EMIL RAPHAEL UNANUE; Fiscal Year: 2010
  8. Recombinant Lactobacillus as an Oral Mucosal Vaccine Against HIV-1
    Gregg Dean; Fiscal Year: 2009
  9. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2009
  10. Vertical transmission of Listeria monocytogenes
    Anna Bakardjiev; Fiscal Year: 2007

Detail Information

Publications218 found, 100 shown here

  1. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
    ..Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen...
  2. pmc Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
    ..Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense...
  3. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
    ..These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection...
  4. ncbi Impaired immune and acute-phase responses in interleukin-6-deficient mice
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Nature 368:339-42. 1994
    ..We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes...
  5. ncbi Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    Koichi S Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 307:731-4. 2005
    ..The Nod2 protein is thus a critical regulator of bacterial immunity within the intestine, providing a possible mechanism for Nod2 mutations in CD...
  6. ncbi Listeria: A foodborne pathogen that knows how to survive
    Megha Gandhi
    Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Int J Food Microbiol 113:1-15. 2007
    ..Studies on the development of technologies to prevent and control L. monocytogenes contamination in foods and food processing facilities are also discussed...
  7. doi The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    Yun Gi Kim
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 28:246-57. 2008
    ..monocytogenes was critically dependent on Nod1 and Nod2 when mice were previously stimulated with lipopolysaccharide or E. coli. Thus, Nod1 and Nod2 are important for microbial recognition and host defense after TLR stimulation...
  8. ncbi Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection
    C Pope
    Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 166:3402-9. 2001
    ..Overall, the results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses...
  9. pmc Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
  10. ncbi Exposure of Listeria monocytogenes within an epidemic caused by butter in Finland
    R Maijala
    Risk Analysis, National Veterinary and Food Research Institute, Helsinki, Finland
    Int J Food Microbiol 70:97-109. 2001
    ..Due to the susceptibility of hospital patients, special care must be taken in order to avoid even low levels of L. monocytogenes in food served...
  11. ncbi Immune responses to Listeria monocytogenes
    Eric G Pamer
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 4:812-23. 2004
    ..These studies, which are yielding one of the most comprehensive pictures of the 'battle' between host and microorganism, are reviewed here...
  12. ncbi Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model
    Marc Lecuit
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Biol Chem 282:15065-72. 2007
    ..Together, these studies establish that hly, rather than bacterial invasion of the lamina propria mediated by InlA, is a dominant determinant of the intensity of the host response to L. monocytogenes infection via the oral route...
  13. pmc Listeria pathogenesis and molecular virulence determinants
    J A Vazquez-Boland
    Grupo de Patogénesis Molecular Bacteriana, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
    Clin Microbiol Rev 14:584-640. 2001
    ....
  14. pmc Molecular epidemiology of an outbreak of febrile gastroenteritis caused by Listeria monocytogenes in cold-smoked rainbow trout
    M K Miettinen
    Department of Food and Environmental Hygiene, 00014 University of Helsinki, Finland
    J Clin Microbiol 37:2358-60. 1999
    ..L. monocytogenes isolates from the incriminated fish product lot and the stool samples were all of serotype 1/2a and were indistinguishable by pulsed-field gel electrophoresis employing AscI and SmaI...
  15. ncbi Unidirectional development of CD8+ central memory T cells into protective Listeria-specific effector memory T cells
    Katharina M Huster
    Clinical Cooperation Group Antigen Specific Immunotherapy, GSF National Research Center of Environment and Health and Technical University Munich, Germany
    Eur J Immunol 36:1453-64. 2006
    ..m.) nor T(EC) (by systemic co-administration of CpG during primary infection) conferred substantial long-term protective immunity. These findings have important implications for the design of more effective T cell-based vaccines...
  16. ncbi A molecular marker for evaluating the pathogenic potential of foodborne Listeria monocytogenes
    Christine Jacquet
    Laboratoire des Listeria, Centre National de Référence des Listeria, World Health Organization Collaborating Center for Foodborne Listeriosis, Institut Pasteur, Paris, France
    J Infect Dis 189:2094-100. 2004
    ..The relevance of these findings for humans is challenged by the observation that some L. monocytogenes isolates express a truncated nonfunctional form of internalin...
  17. ncbi Molecular determinants of Listeria monocytogenes virulence
    Olivier Dussurget
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, 75015 Paris, France
    Annu Rev Microbiol 58:587-610. 2004
    ..This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis...
  18. ncbi Human listeriosis and animal models
    Marc Lecuit
    Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1216-25. 2007
    ..Finally, we present some of the critical determinants for the choice of an appropriate animal model to study human listeriosis...
  19. pmc The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production
    Tina Mahieu
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 103:2292-7. 2006
    ..In contrast to TLR4-deficient mice, SPRET/Ei mice resist both LPS and sepsis induced with Klebsiella pneumoniae...
  20. ncbi Involvement of receptor-interacting protein 2 in innate and adaptive immune responses
    Arnold i Chin
    Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Nature 416:190-4. 2002
    ..Our data reflect requirements for Rip2 in multiple pathways regulating immune and inflammatory responses...
  21. ncbi Auto, a surface associated autolysin of Listeria monocytogenes required for entry into eukaryotic cells and virulence
    Didier Cabanes
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 51:1601-14. 2004
    ..During infection, the autolytic activity of Auto may also be critical. Auto appears thus as a novel type of L. monocytogenes virulence factor...
  22. pmc Cytosolic entry controls CD8+-T-cell potency during bacterial infection
    Keith S Bahjat
    Cerus Corporation, 2411 Stanwell Drive, Concord, CA 94520, USA
    Infect Immun 74:6387-97. 2006
    ..These results reveal a crucial role for phagosomal escape, not for delivery of antigen to the class I major histocompatibility complex pathway but for establishing the appropriate cellular context during CD8+-T-cell priming...
  23. pmc Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection
    Javier A Carrero
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:535-40. 2004
    ..Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins...
  24. doi Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance
    Sheila Ryan
    Department of Microbiology, University College Cork, Cork, Ireland
    Environ Microbiol 11:432-45. 2009
    ..Finally, using the murine model of infection, we have established a role for the ADI system in the virulence of L. monocytogenes...
  25. ncbi Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection
    Anna I Bakardjiev
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    J Infect Dis 191:1889-97. 2005
    ..We concluded that cell-to-cell spread facilitates maternal-to-fetal transmission. Furthermore, the placenta provides a protective niche for growth of L. monocytogenes...
  26. ncbi Multistate outbreak of Listeriosis linked to turkey deli meat and subsequent changes in US regulatory policy
    Sami L Gottlieb
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 42:29-36. 2006
    ..Between July and October 2002, an uncommon strain of L. monocytogenes caused an outbreak of listeriosis in 9 states...
  27. pmc Listeria monocytogenes traffics from maternal organs to the placenta and back
    Anna I Bakardjiev
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    PLoS Pathog 2:e66. 2006
    ..Once colonized, the placenta becomes a nidus of infection resulting in massive reseeding of maternal organs, where L. monocytogenes cannot be cleared until trafficking is interrupted by expulsion of the infected placental tissues...
  28. pmc In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection
    Ana Camejo
    IBMC, Instituto de Biologia Molecular e Celular, Group of Molecular Microbiology, Universidade do Porto, Porto, Portugal
    PLoS Pathog 5:e1000449. 2009
    ..monocytogenes virulence factors, including an LPXTG surface protein, suggesting a role for S-layer glycoproteins and for cadmium efflux system in Listeria virulence...
  29. doi Novel functions of type I interferons revealed by infection studies with Listeria monocytogenes
    Silvia Stockinger
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Dr Bohr Gasse 9 4, A 1030 Vienna, Austria
    Immunobiology 213:889-97. 2008
    ..These in turn sensitise the Listeria host to lethal sequelae of infection with these bacteria. Here, we summarise recent findings on the production and biological effects of type I IFN in the course of L. monocytogenes infection...
  30. pmc Innate and adaptive immune responses to Listeria monocytogenes: a short overview
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Microbes Infect 9:1208-15. 2007
    ..monocytogenes infection. Both the innate and adaptive immune systems are crucial to the recognition and elimination of this pathogen from the host...
  31. ncbi Listeria monocytogenes as a probe of immune function
    Oleg Garifulin
    Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Brief Funct Genomic Proteomic 4:258-69. 2005
    ..monocytogenes infection...
  32. pmc Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes
    Victoria Auerbuch
    Department of Molecular and Cell Biology, 508 Barker Hall, University of California, Berkeley, 94720, USA
    J Exp Med 200:527-33. 2004
    ..The results of this study suggest that L. monocytogenes might be exploiting an innate antiviral response to promote its pathogenesis...
  33. ncbi Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI
    R Endres
    Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Federal Republic of Germany
    Immunity 7:419-32. 1997
    ....
  34. pmc Growth, virulence, and immunogenicity of Listeria monocytogenes aro mutants
    Jochen Stritzker
    Lehrstuhl für Mikrobiologie am Biozentrum der Universität Würzburg, Wurzburg, Germany
    Infect Immun 72:5622-9. 2004
    ....
  35. ncbi Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes
    H W Mittrucker
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 167:5620-7. 2001
    ..However, Ag-specific CD8(+) T cells generated in the absence of CD28 differentiated into normal effector and memory T cells...
  36. ncbi Listeriosis during pregnancy: a case series and review of 222 cases
    Eleftherios Mylonakis
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Medicine (Baltimore) 81:260-9. 2002
  37. pmc A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production
    M Neighbors
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Incorporated, Palo Alto, CA 94304, USA
    J Exp Med 194:343-54. 2001
    ..Tumor necrosis factor (TNF) is also a major player in the resolution of Listeria infections and is suggested to have more global effects than can be explained by the induction of IFN-gamma alone...
  38. ncbi The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes
    O Gaillot
    INSERM U411, Centre Hospitalo Universitaire Necker Enfants Malades, 156, rue de Vaugirard, 75730 Paris Cedex 15, France
    Mol Microbiol 35:1286-94. 2000
    ..These results suggest that ClpP is involved in the rapid adaptive response of intracellular pathogens during the infectious process...
  39. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  40. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
    ....
  41. ncbi Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002
    ..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
  42. ncbi Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
    ....
  43. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  44. ncbi Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses
    Kathryn E Foulds
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:1528-32. 2002
    ..Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells...
  45. pmc Intracellular gene expression profile of Listeria monocytogenes
    Som Subhra Chatterjee
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Infect Immun 74:1323-38. 2006
    ..monocytogenes in host cells. Overall, our study provides crucial insights into the strategy of intracellular survival and measures taken by L. monocytogenes to escape the host cell responses...
  46. doi Listeria monocytogenes, a unique model in infection biology: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Microbes Infect 10:1041-50. 2008
    ..Together, Listeria, after being recognized as a powerful tool in immunology, now appears as one of the most insightful models in infection biology...
  47. pmc Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis
    T Fehr
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Exp Med 185:921-31. 1997
    ....
  48. pmc Construction and characterization of Listeria monocytogenes mutants with in-frame deletions in the response regulator genes identified in the genome sequence
    Tatjana Williams
    Kompetenzzentrum PathoGenoMik, Theodor Boveri Institut für Biowissenschaften der Universität Würzburg Biozentrum, Am Hubland, 97074 Wurzburg, Germany
    Infect Immun 73:3152-9. 2005
    ..The mutant carrying a deletion in the ortholog of the Bacillus subtilis response regulator gene degU showed a clearly reduced virulence in mice, indicating that DegU is involved in the regulation of virulence-associated genes...
  49. pmc Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis
    C Cheers
    Infect Immun 19:755-62. 1978
    ..There was no difference in the response of males and females. In all studies, the powerful overriding influence of the C57B1 genome was evident...
  50. pmc Constitutive Activation of the PrfA regulon enhances the potency of vaccines based on live-attenuated and killed but metabolically active Listeria monocytogenes strains
    Peter Lauer
    Anza Therapeutics, Inc, Concord, CA 94520, USA
    Infect Immun 76:3742-53. 2008
    ..These results form the basis of a rationale for including the prfA(G155S) allele in future live-attenuated or KBMA L. monocytogenes vaccines advanced to the clinical setting...
  51. pmc Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically
    Terri S Hamrick
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Infect Immun 71:5202-9. 2003
    ....
  52. ncbi Reduced apoptosis and ameliorated listeriosis in TRAIL-null mice
    Shi Jun Zheng
    Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5652-8. 2004
    ..Lymphoid and myeloid cell death was significantly inhibited in TRAIL-/- mice, which led to marked enlargement of the spleen. These results establish a critical role for TRAIL in apoptosis during listeriosis...
  53. pmc GILT is a critical host factor for Listeria monocytogenes infection
    Reshma Singh
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06250 8011, USA
    Nature 455:1244-7. 2008
    ..In addition, purified GILT activates recombinant LLO, facilitating membrane permeabilization and red blood cell lysis. The data show that GILT is a critical host factor that facilitates L. monocytogenes infection...
  54. pmc Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice
    B Lu
    Integrated Program of Molecular, Cellular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 95:8233-8. 1998
    ..These results demonstrate that the IFN-gammaR2 is essential for IFN-gamma-mediated immune responses in vivo...
  55. ncbi Listeria monocytogenes: a multifaceted model
    Mélanie Hamon
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris 75015, France
    Nat Rev Microbiol 4:423-34. 2006
    ..Moreover, the vast amount of knowledge that has been gathered through in-depth comparative genomic analyses and in vivo studies makes L. monocytogenes one of the most well-studied bacterial pathogens...
  56. ncbi Hospital-acquired listeriosis
    J C Graham
    Clinical Microbiology Department, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK
    J Hosp Infect 51:136-9. 2002
    ..We discuss the difficulties in preventing food-borne listeriosis in the hospital setting...
  57. pmc A specific gene expression program triggered by Gram-positive bacteria in the cytosol
    Ramona L McCaffrey
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
    Proc Natl Acad Sci U S A 101:11386-91. 2004
    ..Further characterization of cytosolic surveillance pathway(s) and their points of convergence with TLR- and IFN-dependent pathways will enhance our understanding of the means by which mammals detect and respond to pathogens...
  58. ncbi Genetic linkage of resistance to Listeria monocytogenes with macrophage inflammatory responses
    M M Stevenson
    J Immunol 127:402-7. 1981
    ....
  59. ncbi A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier
    M Lecuit
    , Station Centrale de Microscopie Electronique, Institut Pasteur, 75724 Paris Cedex 15, France
    Science 292:1722-5. 2001
    ..These results illustrate how relevant animal models for human infections can be generated...
  60. pmc Plasma cytokine response in mice with bacterial infection
    M Abram
    Department of Microbiology, Medical Faculty, University of Rijeka, Croatia
    Mediators Inflamm 9:229-34. 2000
    ..Exposure to microorganisms elicts the production of cytokines. These soluble factors enhance several innate immune functions and regulate the ensuing specific immune response aimed at limiting the spread of infection...
  61. ncbi Optimization of green fluorescent protein expression vectors for in vitro and in vivo detection of Listeria monocytogenes
    N Fortinea
    Laboratoire de Microbiologie, Institut national de la santé et de la recherche médicale U 411, Faculte de Medecine Necker Enfants Malades, Paris, France
    Res Microbiol 151:353-60. 2000
    ..Listeria cells harboring pNF8 were readily detected in both cultured macrophages and tissue sections. Constructed GFP vectors did not affect the virulence of L. monocytogenes in a murine model of infection...
  62. ncbi Pathogen-specific CD8 T cell responses are directly inhibited by IL-10
    Partha Sarathi Biswas
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 179:4520-8. 2007
    ..Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses...
  63. ncbi Differential expansion, activation and effector functions of conventional and plasmacytoid dendritic cells in mouse tissues transiently infected with Listeria monocytogenes
    Miguel A Tam
    Department of Clinical Immunology, Goteborg University, Goteborg, Sweden
    Cell Microbiol 8:1172-87. 2006
    ..In contrast, IL-12 was induced only with wild-type bacteria. These data provide new insight into the relative abundance and function of distinct CD11c-expressing populations during the early stage of Listeria infection...
  64. pmc Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin
    Marc Lecuit
    Unité des Interactions Bactéries Cellules and Unité d Histotechnologie et Pathologie, Institut Pasteur, Paris 75015, France
    Proc Natl Acad Sci U S A 101:6152-7. 2004
    ..monocytogenes to target and cross the placental barrier. Such a ligand-receptor interaction allowing a pathogen to specifically cross the placental villous trophoblast barrier has not been reported previously...
  65. ncbi Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma
    V P Badovinac
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    Science 290:1354-8. 2000
    ..Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules...
  66. ncbi Priming of memory but not effector CD8 T cells by a killed bacterial vaccine
    G Lauvau
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 294:1735-9. 2001
    ..Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity...
  67. ncbi Two consecutive nationwide outbreaks of Listeriosis in France, October 1999-February 2000
    H De Valk
    Institut de Veille Sanitaire, St Maurice, France
    Am J Epidemiol 154:944-50. 2001
    ..monocytogenes strains to allow early detection and separate investigation of different clusters...
  68. ncbi The specific and essential role of MAVS in antiviral innate immune responses
    Qinmiao Sun
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Immunity 24:633-42. 2006
    ..These results provide the in vivo evidence that the cytosolic viral signaling pathway through MAVS is specifically required for innate immune responses against viral infection...
  69. ncbi Foodborne listeriosis
    W F Schlech
    Division of Infectious Diseases, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    Clin Infect Dis 31:770-5. 2000
    ..Microbial virulence factors distinguishing environmental strains of L. monocytogenes from invasive strains causing foodborne illness and host factors promoting human infection remain incompletely understood...
  70. pmc Listeria monocytogenes mutants that fail to compartmentalize listerolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses
    Ian J Glomski
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Infect Immun 71:6754-65. 2003
    ..We concluded that L. monocytogenes controls the cytolytic activity of LLO to maintain its nutritionally rich intracellular niche and avoid extracellular defenses of the host...
  71. pmc Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence
    Rosemarie Rea
    Department of Microbiology, University College Cork, Cork, Ireland
    Appl Environ Microbiol 71:8314-22. 2005
    ....
  72. doi Listeria monocytogenes internalins bind to the human intestinal mucin MUC2
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, QLD, 4101, Australia
    Arch Microbiol 190:101-4. 2008
    ..We report here that the internalin domain of the InlJ protein also bound MUC2, suggesting that an internalin domain is sufficient to bind to MUC2...
  73. ncbi Selective depletion of nonspecific T cells during the early stage of immune responses to infection
    Jiu Jiang
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6076, USA
    J Immunol 171:4352-8. 2003
    ..These results have important implications for our understanding of early events in the development of a robust T cell response...
  74. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
  75. ncbi FbpA, a novel multifunctional Listeria monocytogenes virulence factor
    S Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
    Mol Microbiol 53:639-49. 2004
    ..Thus, FbpA, in addition to being a fibronectin-binding protein, behaves as a chaperone or an escort protein for two important virulence factors and appears as a novel multifunctional virulence factor of L. monocytogenes...
  76. ncbi Immune response in mice that lack the interferon-gamma receptor
    S Huang
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 259:1742-5. 1993
    ..These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor...
  77. pmc Nationwide outbreak of listeriosis due to contaminated meat
    P S Mead
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Epidemiol Infect 134:744-51. 2006
    ..Standardized molecular subtyping and coordinated, multi-jurisdiction investigations can greatly facilitate detection and control of listeriosis outbreaks...
  78. ncbi The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5210-8. 2003
    ..tuberculosis infection as wild-type mice, these data demonstrate that signaling of LT alpha(1)beta(2) heterotrimers via the LT beta R is an essential prerequisite for containment of intracellular pathogens...
  79. ncbi Evaluation of farm management practices as risk factors for clinical listeriosis and fecal shedding of Listeria monocytogenes in ruminants
    Kendra K Nightingale
    Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 227:1808-14. 2005
    ..To assess seasonal variation in prevalence of Listeria monocytogenes on ruminant farms and identify management practices associated with ruminant listeriosis and fecal shedding of L. monocytogenes...
  80. ncbi Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    J Immunol 153:3116-22. 1994
    ..monocytogenes and point to the necessity of a coordinated interaction between CD8 and CD4 alpha beta T cells (and probably gamma delta T cells) in anti-L. monocytogenes resistance...
  81. pmc Rapid development of a gamma interferon-secreting glycolipid/CD1d-specific Valpha14+ NK1.1- T-cell subset after bacterial infection
    Masashi Emoto
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Infect Immun 74:5903-13. 2006
    ..1- T-cell subset to antibacterial protection is covered by more profound detrimental effects of the NK1.1+ T-cell subset...
  82. ncbi [Molecular epidemiology of Listeria monocytogenes infections in a health district of Madrid in a 3-year period (2001-2003)]
    Mónica García-Álvarez
    Servicio de Microbiologia, Hospital 12 de Octubre, Madrid, Espana
    Enferm Infecc Microbiol Clin 24:86-9. 2006
    ..The objectives of this study were to review the clinical characteristics of the cases diagnosed from 2001 to 2003 and to investigate clonal relationships among the clinical isolates of Listeria monocytogenes...
  83. ncbi Cytoplasmic bacteria can be targets for autophagy
    Kathryn A Rich
    Ahmanson Advanced Electron Microscopy and Imaging Center, House Ear Institute, and Department of Pathology, Keck School of Medicine, USC, Los Angeles, CA, USA
    Cell Microbiol 5:455-68. 2003
    ....
  84. pmc Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genes
    Norman Mauder
    Lehrstuhl fur Mikrobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Bacteriol 188:7941-56. 2006
    ..monocytogenes leads to low expression of PrfA-dependent genes and to reduced in vivo virulence of L. monocytogenes, suggesting that the altered properties of PrfA(Ls) protein are a major cause for the low virulence of L. seeligeri...
  85. ncbi Coexpression of virulence and fosfomycin susceptibility in Listeria: molecular basis of an antimicrobial in vitro-in vivo paradox
    Mariela Scortti
    Bacterial Molecular Pathogenesis Group, Faculty of Medical and Veterinary Sciences, University of Bristol, Langford BS40 5DU, UK
    Nat Med 12:515-7. 2006
    ..These bacteria therefore seem resistant to fosfomycin in vitro, although they are in fact susceptible to the antibiotic during infection...
  86. ncbi A review of the incidence and transmission of Listeria monocytogenes in ready-to-eat products in retail and food service environments
    Alexandra Lianou
    Center for Red Meat Safety, Department of Animal Sciences, Colorado State University, Fort Collins, Colorado 80523 1171, USA
    J Food Prot 70:2172-98. 2007
    ..monocytogenes in these environments. However, competent delivery of food safety education and training to retail and food service managers and food handlers must be in place for successful implementation of such a system...
  87. ncbi Avirulence of viable but non-culturable Listeria monocytogenes cells demonstrated by in vitro and in vivo models
    Jean Michel Cappelier
    Unité Mixte de Recherche SECALIM INRA ENVN, Ecole Nationale Veterinaire de Nantes, BP 40706, Route de Gachet, 44307 Nantes, France
    Vet Res 36:589-99. 2005
    ..Further studies are needed in order to investigate the virulence of VBNC cells of Listeria monocytogenes after recovery of a culturable state...
  88. ncbi An outbreak of febrile gastroenteritis associated with corn contaminated by Listeria monocytogenes
    P Aureli
    Reparto di Microbiologia degli Alimenti, Laboratorio Alimenti, Istituto Superiore di Sanita, Rome, Italy
    N Engl J Med 342:1236-41. 2000
    ..On May 21, 1997, numerous cases of febrile gastrointestinal illness were reported among the students and staff of two primary schools in northern Italy, all of whom had eaten at cafeterias served by the same caterer...
  89. pmc Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice
    H W Rogers
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 89:1011-5. 1992
    ....
  90. pmc Mechanism of polarization of Listeria monocytogenes surface protein ActA
    Susanne M Rafelski
    Department of Biochemistry, Stanford University Medical Center, 279 W Campus Dr, Stanford, CA 94305 5307, USA
    Mol Microbiol 59:1262-79. 2006
    ....
  91. ncbi Quantitative risk assessment of Listeria monocytogenes in ready-to-eat foods: the FAO/WHO approach
    J Rocourt
    World Health Organization, Food Safety Programme, Avenue Apia, 1211, Geneva 27, Switzerland
    FEMS Immunol Med Microbiol 35:263-7. 2003
    ..Preliminary data indicate that eliminating the higher dose levels at the time of consumption has a large impact on the number of predicted cases...
  92. pmc Lymphocytes serve as a reservoir for Listeria monocytogenes growth during infection of mice
    Denise S McElroy
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    Microb Pathog 46:214-21. 2009
    ..These results suggest that lymphocytes can be a reservoir for L. monocytogenes growth in vivo...
  93. ncbi Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses
    Peter Aichele
    Abteilung Immunologie, Max Planck Institut für Infektionsbiologie, Berlin, Germany
    J Immunol 171:1148-55. 2003
    ..Therefore, marginal zone macrophages and marginal metallophilic macrophages are crucial for trapping of particulate Ag but dispensable for Ag presentation...
  94. pmc Construction of a multiple fluorescence labelling system for use in co-invasion studies of Listeria monocytogenes
    Jens B Andersen
    Danish Institute for Food and Veterinary Research, Department of Microbiological Food Safety, Mørkhøj Bygade 19, 2860 Søborg, Denmark
    BMC Microbiol 6:86. 2006
    ..One way to circumvent this problem is to carry out virulence studies as competition assays between 2 or more strains. This, however, requires invasion-neutral markers that enable easy discrimination between the different strains...
  95. pmc In vitro and in vivo invasiveness of different pulsed-field gel electrophoresis types of Listeria monocytogenes
    Charlotte Nexmann Larsen
    Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Appl Environ Microbiol 68:5698-703. 2002
    ..monocytogenes cells were performed for isolates of PFGE types 1, 2, 5, and 15. After 2 days, equal amounts of bacteria were observed in the liver and spleen of the rats for any of the PFGE types tested...
  96. pmc Intraspecific phylogeny and lineage group identification based on the prfA virulence gene cluster of Listeria monocytogenes
    Todd J Ward
    Microbial Genomics and Bioprocessing Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, 1815 North University St, Peoria, IL 61604, USA
    J Bacteriol 186:4994-5002. 2004
    ..monocytogenes lineages may represent distinct species within the framework of the cohesion species concept...
  97. pmc Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases
    Sofia Xanthoulea
    Institute of Immunology, Biomedical Sciences Research Centre Al Fleming, 34 Al Fleming St, Vari 166 72, Greece
    J Exp Med 200:367-76. 2004
    ..Assessment of p55TNFR shedding may thus be of prognostic value in infectious, inflammatory, and autoimmune diseases...
  98. ncbi Diversity of Listeria monocytogenes isolates of human and food origin studied by serotyping, automated ribotyping and pulsed-field gel electrophoresis
    S Lukinmaa
    Laboratory of Enteric Pathogens, National Public Health Institute, Helsinki, Finland
    Clin Microbiol Infect 10:562-8. 2004
    ..Although ribotyping is applicable as the first method in outbreak situations, human and food isolates with identical ribotypes should be investigated further by PFGE...
  99. ncbi Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity
    Sing Sing Way
    Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357650, H564, Seattle, WA 98195, USA
    Cell Microbiol 6:235-42. 2004
    ..These data indicate that flagellin is not essential for LM pathogenesis or for the induction of LM-specific adaptive immune responses in normal mice...
  100. ncbi Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:891-901. 2003
    ..Our results indicate that distinct microbial signals activate innate immune responses in an ordered, step-wise fashion, providing a mechanism to specify and modulate antimicrobial effector functions...
  101. pmc Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
    Emily C Lutterloh
    Division of Infectious Diseases, Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02860, USA
    Crit Care 11:R122. 2007
    ..The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis...

Research Grants82

  1. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  2. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen Gregory; Fiscal Year: 2007
    ..Consequently, they should provide valuable insights that will enable the development of innovative strategies to improve treatment and to prevent the devastating consequences often associated with septicemia and sepsis. ..
  3. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen Gregory; Fiscal Year: 2009
    ..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..
  4. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen H Gregory; Fiscal Year: 2010
    ..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..
  5. FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATION
    Stephen Gregory; Fiscal Year: 2004
    ..abstract_text> ..
  6. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2006
    ..Our studies will shed light on the important interactions between innate immunity and adaptive T cell responses. ..
  7. Immunity to Intracellular Pathogens
    EMIL RAPHAEL UNANUE; Fiscal Year: 2010
    ..Studying the biochemical and cellular basis of such a protein will give us insights on how antigens are presented during microbial infection. ..
  8. Recombinant Lactobacillus as an Oral Mucosal Vaccine Against HIV-1
    Gregg Dean; Fiscal Year: 2009
    ..Studies proposed here will investigate strategies to engineer recombinant L. gasseri that can induce a protective immune response against HIV-1 via the oral mucosa. ..
  9. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2009
    ..abstract_text> ..
  10. Vertical transmission of Listeria monocytogenes
    Anna Bakardjiev; Fiscal Year: 2007
    ..The proposed research will provide important training which will prove crucial for the applicant when she becomes an independent physician scientist, her long-term goal. ..
  11. BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIV
    Gregg Dean; Fiscal Year: 2007
    ..Together these studies will elucidate the cellular mechanisms that underlie the innate immune defect and investigate potential molecular mechanisms. ..
  12. CC-chemokines in Listeria infection.
    Eric Pamer; Fiscal Year: 2007
    ....
  13. BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIV
    Gregg Dean; Fiscal Year: 2004
    ..ompounds. ..
  14. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2004
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..
  15. T LYMPHOCYTE RESPONSES TO LISTERIA INFECTION
    Eric Pamer; Fiscal Year: 2002
    ..These experiments will shed light on how the size of the T cell response to an epitope is determined in vivo and are likely to provide ideas for optimizing vaccines which elicit dominant, long term T lymphocyte responses. ..
  16. L. MONOCYTOGENES CLONAL GROUPS: ECOLOGY AND TRANSMISSION
    Martin Wiedmann; Fiscal Year: 2004
    ..4. Determine the phenotypes of L. monocytogenes clonal groups associated with specific environments and hosts and determine the genetic basis for phenotypes associated with a preference for specific habitats...
  17. TNF Mediated Immune Defense Against Listeria Infection
    Eric Pamer; Fiscal Year: 2007
    ....
  18. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2004
    ..This approach should offer a rational explanation for immunogenicity that avoids the empiricisms of results based only on T cell assays. ..
  19. LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLS
    NANCY ELIZABETH FREITAG; Fiscal Year: 2010
    ..The ultimate goal of the proposed work is to elucidate the regulatory pathways that enable bacterial survival within host cells, and the functional identification of additional bacterial factors that support replication within the host. ..
  20. LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLS
    NANCY ELIZABETH FREITAG; Fiscal Year: 2010
    ....
  21. LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLS
    Nancy Freitag; Fiscal Year: 2005
    ..This information is important towards better definition of the interactions that occur between host and pathogen during the process of infection. ..
  22. Etiologic studies on EMND: An animal model for ALS
    Hussni Mohammed; Fiscal Year: 2004
    ..Data obtained from these pilot studies will represent a major breakthrough towards the understanding of the mechanism of the motor neuron disease and lay the foundation for more thorough investigation. ..
  23. Host-pathogen Genetics Using Listeria and Drosophila
    Nancy Freitag; Fiscal Year: 2007
    ..abstract_text> ..
  24. ROLE OF ATP-BINDING CASSETTE TRANSPORTERS IN INNATE INTESTINAL DEFENSE
    Brien Neudeck; Fiscal Year: 2007
    ..Once this is accomplished, we can use this information to develop protective strategies that exploit these preexisting barriers to L. monocytogenes and potentially other pathogens. ..