listeria infections

Summary

Summary: Infections with bacteria of the genus LISTERIA.

Top Publications

  1. ncbi Cytosolic localization of Listeria monocytogenes triggers an early IFN-gamma response by CD8+ T cells that correlates with innate resistance to infection
    Sarah E F D'Orazio
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    J Immunol 177:7146-54. 2006
  2. ncbi Listeria monocytogenes, a unique model in infection biology: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Microbes Infect 10:1041-50. 2008
  3. ncbi Human listeriosis and animal models
    Marc Lecuit
    Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1216-25. 2007
  4. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
  5. ncbi Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
  6. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
  7. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
  8. ncbi Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
  9. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
  10. ncbi Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002

Research Grants

  1. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
  2. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen Gregory; Fiscal Year: 2007
  3. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen Gregory; Fiscal Year: 2009
  4. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen H Gregory; Fiscal Year: 2010
  5. FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATION
    Stephen Gregory; Fiscal Year: 2004
  6. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2006
  7. Immunity to Intracellular Pathogens
    EMIL RAPHAEL UNANUE; Fiscal Year: 2010
  8. Recombinant Lactobacillus as an Oral Mucosal Vaccine Against HIV-1
    Gregg Dean; Fiscal Year: 2009
  9. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2009
  10. Vertical transmission of Listeria monocytogenes
    Anna Bakardjiev; Fiscal Year: 2007

Detail Information

Publications182 found, 100 shown here

  1. ncbi Cytosolic localization of Listeria monocytogenes triggers an early IFN-gamma response by CD8+ T cells that correlates with innate resistance to infection
    Sarah E F D'Orazio
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    J Immunol 177:7146-54. 2006
    ..These data suggest that participation of memory CD8+ T cells in the early immune response against L. monocytogenes correlates with innate host resistance to infection...
  2. ncbi Listeria monocytogenes, a unique model in infection biology: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Microbes Infect 10:1041-50. 2008
    ..Together, Listeria, after being recognized as a powerful tool in immunology, now appears as one of the most insightful models in infection biology...
  3. ncbi Human listeriosis and animal models
    Marc Lecuit
    Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1216-25. 2007
    ..Finally, we present some of the critical determinants for the choice of an appropriate animal model to study human listeriosis...
  4. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
    ..These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection...
  5. ncbi Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
    ..Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense...
  6. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
    ....
  7. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  8. ncbi Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
    ....
  9. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  10. ncbi Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002
    ..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
  11. ncbi Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
  12. ncbi Innate and adaptive immune responses to Listeria monocytogenes: a short overview
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Microbes Infect 9:1208-15. 2007
    ..monocytogenes infection. Both the innate and adaptive immune systems are crucial to the recognition and elimination of this pathogen from the host...
  13. ncbi Listeria pathogenesis and molecular virulence determinants
    J A Vazquez-Boland
    Grupo de Patogénesis Molecular Bacteriana, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
    Clin Microbiol Rev 14:584-640. 2001
    ....
  14. ncbi GILT is a critical host factor for Listeria monocytogenes infection
    Reshma Singh
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06250 8011, USA
    Nature 455:1244-7. 2008
    ..In addition, purified GILT activates recombinant LLO, facilitating membrane permeabilization and red blood cell lysis. The data show that GILT is a critical host factor that facilitates L. monocytogenes infection...
  15. ncbi Impaired immune and acute-phase responses in interleukin-6-deficient mice
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Nature 368:339-42. 1994
    ..We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes...
  16. ncbi The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes
    O Gaillot
    INSERM U411, Centre Hospitalo Universitaire Necker Enfants Malades, 156, rue de Vaugirard, 75730 Paris Cedex 15, France
    Mol Microbiol 35:1286-94. 2000
    ..These results suggest that ClpP is involved in the rapid adaptive response of intracellular pathogens during the infectious process...
  17. ncbi Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection
    Javier A Carrero
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:535-40. 2004
    ..Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins...
  18. ncbi The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    Yun Gi Kim
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 28:246-57. 2008
    ..monocytogenes was critically dependent on Nod1 and Nod2 when mice were previously stimulated with lipopolysaccharide or E. coli. Thus, Nod1 and Nod2 are important for microbial recognition and host defense after TLR stimulation...
  19. ncbi Differential expansion, activation and effector functions of conventional and plasmacytoid dendritic cells in mouse tissues transiently infected with Listeria monocytogenes
    Miguel A Tam
    Department of Clinical Immunology, , , Sweden
    Cell Microbiol 8:1172-87. 2006
    ..In contrast, IL-12 was induced only with wild-type bacteria. These data provide new insight into the relative abundance and function of distinct CD11c-expressing populations during the early stage of Listeria infection...
  20. ncbi Pathogen-specific CD8 T cell responses are directly inhibited by IL-10
    Partha Sarathi Biswas
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 179:4520-8. 2007
    ..Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses...
  21. ncbi Immune responses to Listeria monocytogenes
    Eric G Pamer
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 4:812-23. 2004
    ..These studies, which are yielding one of the most comprehensive pictures of the 'battle' between host and microorganism, are reviewed here...
  22. ncbi Optimization of green fluorescent protein expression vectors for in vitro and in vivo detection of Listeria monocytogenes
    N Fortinea
    Laboratoire de Microbiologie, Institut national de la santé et de la recherche médicale U 411, Faculte de Medecine Necker Enfants Malades, Paris, France
    Res Microbiol 151:353-60. 2000
    ..Listeria cells harboring pNF8 were readily detected in both cultured macrophages and tissue sections. Constructed GFP vectors did not affect the virulence of L. monocytogenes in a murine model of infection...
  23. ncbi Listeria monocytogenes traffics from maternal organs to the placenta and back
    Anna I Bakardjiev
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    PLoS Pathog 2:e66. 2006
    ..Once colonized, the placenta becomes a nidus of infection resulting in massive reseeding of maternal organs, where L. monocytogenes cannot be cleared until trafficking is interrupted by expulsion of the infected placental tissues...
  24. ncbi Immune response in mice that lack the interferon-gamma receptor
    S Huang
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 259:1742-5. 1993
    ..These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor...
  25. ncbi Selective depletion of nonspecific T cells during the early stage of immune responses to infection
    Jiu Jiang
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA
    J Immunol 171:4352-8. 2003
    ..These results have important implications for our understanding of early events in the development of a robust T cell response...
  26. ncbi FbpA, a novel multifunctional Listeria monocytogenes virulence factor
    S Dramsi
    , Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
    Mol Microbiol 53:639-49. 2004
    ..Thus, FbpA, in addition to being a fibronectin-binding protein, behaves as a chaperone or an escort protein for two important virulence factors and appears as a novel multifunctional virulence factor of L. monocytogenes...
  27. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
  28. ncbi Nationwide outbreak of listeriosis due to contaminated meat
    P S Mead
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Epidemiol Infect 134:744-51. 2006
    ..Standardized molecular subtyping and coordinated, multi-jurisdiction investigations can greatly facilitate detection and control of listeriosis outbreaks...
  29. ncbi The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5210-8. 2003
    ..tuberculosis infection as wild-type mice, these data demonstrate that signaling of LT alpha(1)beta(2) heterotrimers via the LT beta R is an essential prerequisite for containment of intracellular pathogens...
  30. ncbi Listeria monocytogenes: a multifaceted model
    Mélanie Hamon
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris 75015, France
    Nat Rev Microbiol 4:423-34. 2006
    ..Moreover, the vast amount of knowledge that has been gathered through in-depth comparative genomic analyses and in vivo studies makes L. monocytogenes one of the most well-studied bacterial pathogens...
  31. ncbi Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:891-901. 2003
    ..Our results indicate that distinct microbial signals activate innate immune responses in an ordered, step-wise fashion, providing a mechanism to specify and modulate antimicrobial effector functions...
  32. ncbi Exploration of host-pathogen interactions using Listeria monocytogenes and Drosophila melanogaster
    Bryce E Mansfield
    Department of Pathobiology, University of Washington, USA
    Cell Microbiol 5:901-11. 2003
    ..monocytogenes infection...
  33. ncbi In vitro and in vivo invasiveness of different pulsed-field gel electrophoresis types of Listeria monocytogenes
    Charlotte Nexmann Larsen
    Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Appl Environ Microbiol 68:5698-703. 2002
    ..monocytogenes cells were performed for isolates of PFGE types 1, 2, 5, and 15. After 2 days, equal amounts of bacteria were observed in the liver and spleen of the rats for any of the PFGE types tested...
  34. ncbi Construction of a multiple fluorescence labelling system for use in co-invasion studies of Listeria monocytogenes
    Jens B Andersen
    Danish Institute for Food and Veterinary Research, Department of Microbiological Food Safety, Mørkhøj Bygade 19, 2860 Søborg, Denmark
    BMC Microbiol 6:86. 2006
    ..One way to circumvent this problem is to carry out virulence studies as competition assays between 2 or more strains. This, however, requires invasion-neutral markers that enable easy discrimination between the different strains...
  35. ncbi Rapid development of a gamma interferon-secreting glycolipid/CD1d-specific Valpha14+ NK1.1- T-cell subset after bacterial infection
    Masashi Emoto
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    Infect Immun 74:5903-13. 2006
    ..1- T-cell subset to antibacterial protection is covered by more profound detrimental effects of the NK1.1+ T-cell subset...
  36. ncbi Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity
    Sing Sing Way
    Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357650, H564, Seattle, WA 98195, USA
    Cell Microbiol 6:235-42. 2004
    ..These data indicate that flagellin is not essential for LM pathogenesis or for the induction of LM-specific adaptive immune responses in normal mice...
  37. ncbi Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genes
    Norman Mauder
    , Biozentrum, , Am Hubland, , Germany
    J Bacteriol 188:7941-56. 2006
    ..monocytogenes leads to low expression of PrfA-dependent genes and to reduced in vivo virulence of L. monocytogenes, suggesting that the altered properties of PrfA(Ls) protein are a major cause for the low virulence of L. seeligeri...
  38. ncbi Evaluation of farm management practices as risk factors for clinical listeriosis and fecal shedding of Listeria monocytogenes in ruminants
    Kendra K Nightingale
    Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 227:1808-14. 2005
    ..Awareness of risk factors may be used to develop control measures to reduce animal disease and introduction of L. monocytogenes into the human food chain...
  39. ncbi Mechanism of polarization of Listeria monocytogenes surface protein ActA
    Susanne M Rafelski
    Department of Biochemistry, Stanford University Medical Center, 279 W. Campus Dr, Stanford, CA 94305-5307, USA
    Mol Microbiol 59:1262-79. 2006
    ....
  40. ncbi [Molecular epidemiology of Listeria monocytogenes infections in a health district of Madrid in a 3-year period (2001-2003)]
    Mónica García-Álvarez
    Servicio de Microbiologia, Hospital 12 de Octubre, Madrid, Espana
    Enferm Infecc Microbiol Clin 24:86-9. 2006
    ..The objectives of this study were to review the clinical characteristics of the cases diagnosed from 2001 to 2003 and to investigate clonal relationships among the clinical isolates of Listeria monocytogenes...
  41. ncbi Construction and characterization of Listeria monocytogenes mutants with in-frame deletions in the response regulator genes identified in the genome sequence
    Tatjana Williams
    Kompetenzzentrum PathoGenoMik, , Am Hubland, , Germany
    Infect Immun 73:3152-9. 2005
    ..The mutant carrying a deletion in the ortholog of the Bacillus subtilis response regulator gene degU showed a clearly reduced virulence in mice, indicating that DegU is involved in the regulation of virulence-associated genes...
  42. ncbi Avirulence of viable but non-culturable Listeria monocytogenes cells demonstrated by in vitro and in vivo models
    Jean Michel Cappelier
    Unité Mixte de Recherche SECALIM INRA ENVN, Ecole Nationale Veterinaire de Nantes, BP 40706, Route de Gachet, 44307 Nantes, France
    Vet Res 36:589-99. 2005
    ..Further studies are needed in order to investigate the virulence of VBNC cells of Listeria monocytogenes after recovery of a culturable state...
  43. ncbi Unidirectional development of CD8+ central memory T cells into protective Listeria-specific effector memory T cells
    Katharina M Huster
    Clinical Cooperation Group 'Antigen-Specific Immunotherapy, GSF - National Research Center of Environment and Health and Technical University Munich, Germany
    Eur J Immunol 36:1453-64. 2006
    ..m.) nor T(EC) (by systemic co-administration of CpG during primary infection) conferred substantial long-term protective immunity. These findings have important implications for the design of more effective T cell-based vaccines...
  44. ncbi Coexpression of virulence and fosfomycin susceptibility in Listeria: molecular basis of an antimicrobial in vitro-in vivo paradox
    Mariela Scortti
    Bacterial Molecular Pathogenesis Group, Faculty of Medical and Veterinary Sciences, University of Bristol, Langford BS40 5DU, UK
    Nat Med 12:515-7. 2006
    ..These bacteria therefore seem resistant to fosfomycin in vitro, although they are in fact susceptible to the antibiotic during infection...
  45. ncbi Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases
    Sofia Xanthoulea
    Institute of Immunology, Biomedical Sciences Research Centre Al Fleming, 34 Al Fleming St, Vari 166 72, Greece
    J Exp Med 200:367-76. 2004
    ..Assessment of p55TNFR shedding may thus be of prognostic value in infectious, inflammatory, and autoimmune diseases...
  46. ncbi A specific gene expression program triggered by Gram-positive bacteria in the cytosol
    Ramona L McCaffrey
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA
    Proc Natl Acad Sci U S A 101:11386-91. 2004
    ..Further characterization of cytosolic surveillance pathway(s) and their points of convergence with TLR- and IFN-dependent pathways will enhance our understanding of the means by which mammals detect and respond to pathogens...
  47. ncbi Diversity of Listeria monocytogenes isolates of human and food origin studied by serotyping, automated ribotyping and pulsed-field gel electrophoresis
    S Lukinmaa
    Laboratory of Enteric Pathogens, National Public Health Institute, Helsinki, Finland
    Clin Microbiol Infect 10:562-8. 2004
    ..Although ribotyping is applicable as the first method in outbreak situations, human and food isolates with identical ribotypes should be investigated further by PFGE...
  48. ncbi Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin
    Marc Lecuit
    Unité des Interactions Bactéries Cellules and Unité d Histotechnologie et Pathologie, Institut Pasteur, Paris 75015, France
    Proc Natl Acad Sci U S A 101:6152-7. 2004
    ..monocytogenes to target and cross the placental barrier. Such a ligand-receptor interaction allowing a pathogen to specifically cross the placental villous trophoblast barrier has not been reported previously...
  49. ncbi Intraspecific phylogeny and lineage group identification based on the prfA virulence gene cluster of Listeria monocytogenes
    Todd J Ward
    Microbial Genomics and Bioprocessing Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, 1815 North University St, Peoria, IL 61604, USA
    J Bacteriol 186:4994-5002. 2004
    ..monocytogenes lineages may represent distinct species within the framework of the cohesion species concept...
  50. ncbi Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection
    C H Ladel
    Department of Immunology, University of Ulm, Germany
    J Immunol 153:3116-22. 1994
    ..monocytogenes and point to the necessity of a coordinated interaction between CD8 and CD4 alpha beta T cells (and probably gamma delta T cells) in anti-L. monocytogenes resistance...
  51. ncbi Mutations in the listerial proB gene leading to proline overproduction: effects on salt tolerance and murine infection
    R D Sleator
    Department of Microbiology and National Food Biotechnology Centre, University College Cork, Cork, Ireland
    Appl Environ Microbiol 67:4560-5. 2001
    ..However, our results suggest that as previously described for proline auxotrophy, proline hyperproduction has no apparent impact on the virulence potential of Listeria...
  52. ncbi Cytoplasmic bacteria can be targets for autophagy
    Kathryn A Rich
    Ahmanson Advanced Electron Microscopy and Imaging Center, House Ear Institute, and Department of Pathology, Keck School of Medicine, USC, Los Angeles, CA, USA
    Cell Microbiol 5:455-68. 2003
    ....
  53. ncbi Foodborne listeriosis
    W F Schlech
    Division of Infectious Diseases, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    Clin Infect Dis 31:770-5. 2000
    ..Microbial virulence factors distinguishing environmental strains of L. monocytogenes from invasive strains causing foodborne illness and host factors promoting human infection remain incompletely understood...
  54. ncbi An outbreak of febrile gastroenteritis associated with corn contaminated by Listeria monocytogenes
    P Aureli
    Reparto di Microbiologia degli Alimenti, Laboratorio Alimenti, Istituto Superiore di Sanita, Rome, Italy
    N Engl J Med 342:1236-41. 2000
    ..On May 21, 1997, numerous cases of febrile gastrointestinal illness were reported among the students and staff of two primary schools in northern Italy, all of whom had eaten at cafeterias served by the same caterer...
  55. ncbi Novel functions of type I interferons revealed by infection studies with Listeria monocytogenes
    Silvia Stockinger
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Dr Bohr Gasse 9 4, A 1030 Vienna, Austria
    Immunobiology 213:889-97. 2008
    ..These in turn sensitise the Listeria host to lethal sequelae of infection with these bacteria. Here, we summarise recent findings on the production and biological effects of type I IFN in the course of L. monocytogenes infection...
  56. ncbi Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance
    Sheila Ryan
    Department of Microbiology, University College Cork, Cork, Ireland
    Environ Microbiol 11:432-45. 2009
    ..Finally, using the murine model of infection, we have established a role for the ADI system in the virulence of L. monocytogenes...
  57. ncbi Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis
    T Fehr
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Exp Med 185:921-31. 1997
    ....
  58. ncbi Lymphocytes serve as a reservoir for Listeria monocytogenes growth during infection of mice
    Denise S McElroy
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    Microb Pathog 46:214-21. 2009
    ..These results suggest that lymphocytes can be a reservoir for L. monocytogenes growth in vivo...
  59. ncbi Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
    Emily C Lutterloh
    Division of Infectious Diseases, Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02860, USA
    Crit Care 11:R122. 2007
    ..The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis...
  60. ncbi Quantitative risk assessment of Listeria monocytogenes in ready-to-eat foods: the FAO/WHO approach
    J Rocourt
    World Health Organization, Food Safety Programme, Avenue Apia, 1211, Geneva 27, Switzerland
    FEMS Immunol Med Microbiol 35:263-7. 2003
    ..Preliminary data indicate that eliminating the higher dose levels at the time of consumption has a large impact on the number of predicted cases...
  61. ncbi Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses
    Peter Aichele
    Abteilung Immunologie, , Berlin, Germany
    J Immunol 171:1148-55. 2003
    ..Therefore, marginal zone macrophages and marginal metallophilic macrophages are crucial for trapping of particulate Ag but dispensable for Ag presentation...
  62. ncbi Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice
    H W Rogers
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 89:1011-5. 1992
    ....
  63. ncbi A review of the incidence and transmission of Listeria monocytogenes in ready-to-eat products in retail and food service environments
    Alexandra Lianou
    Center for Red Meat Safety, Department of Animal Sciences, Colorado State University, Fort Collins, Colorado 80523 1171, USA
    J Food Prot 70:2172-98. 2007
    ..monocytogenes in these environments. However, competent delivery of food safety education and training to retail and food service managers and food handlers must be in place for successful implementation of such a system...
  64. ncbi Reduced apoptosis and ameliorated listeriosis in TRAIL-null mice
    Shi Jun Zheng
    Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5652-8. 2004
    ..Lymphoid and myeloid cell death was significantly inhibited in TRAIL-/- mice, which led to marked enlargement of the spleen. These results establish a critical role for TRAIL in apoptosis during listeriosis...
  65. ncbi Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells
    Taiki Aoshi
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Immunity 29:476-86. 2008
    ..Our study suggests that splenic dendritic cells rapidly deliver intracellular bacteria to the T cell areas of the white pulp to initiate CD8(+) T cell responses...
  66. ncbi n-3 PUFA fail to affect in vivo, antigen-driven CD8+T-cell proliferation in the spleen of naïve mice
    Robert Irons
    Nutritional Sciences Program, University of Missouri, Columbia, MO 65211, USA
    Br J Nutr 95:838-44. 2006
    ..To our knowledge this is the first time MHC tetramers have been used to investigate the influence of n-3 PUFA on in vivo CD8(+)T-cell proliferation...
  67. ncbi A truncated Bacillus subtilis dal gene with a 3' ssrA gene tag regulates the growth and virulence of racemase-deficient Listeria monocytogenes
    Zhongxia Li
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Microbiology 152:3091-102. 2006
    ..These bacteria can thus induce immune responses in mice comparable to the original Lmdd strain, but without the need for exogenous d-alanine, and may have use as a live vaccine vector against infectious diseases and cancers...
  68. ncbi Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease
    Keith S Bahjat
    Cerus Corporation, Concord, CA 94520, USA
    J Immunol 179:7376-84. 2007
    ....
  69. ncbi Probiotic Lactobacillus casei activates innate immunity via NF-kappaB and p38 MAP kinase signaling pathways
    Yun-Gi Kim
    Department of Microbiology, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
    Microbes Infect 8:994-1005. 2006
    ..casei ATCC27139, suggesting that both NF-kappaB and p38 MAPK signaling pathways play important roles in the augmentation of innate immunity by the probiotic L. casei...
  70. ncbi H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes
    Sarah E F D'Orazio
    Department of Microbiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    J Exp Med 203:383-91. 2006
    ..These data suggest that M3-restricted T cells are not required for protection against L. monocytogenes and underscore the importance of searching for new antigen-presenting molecules among the large MHC-Ib family of proteins...
  71. ncbi Generation of CD8 T cell memory is regulated by IL-12
    Erika L Pearce
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 179:2074-81. 2007
    ..These results have implications for understanding memory T cell development and enhancing vaccine efficacy, and offer new insight into the role of IL-12 in coordinating the innate and adaptive immune response...
  72. ncbi A role for IFN-gamma from antigen-specific CD8+ T cells in protective immunity to Listeria monocytogenes
    Kelly A N Messingham
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 179:2457-66. 2007
    ....
  73. ncbi Decreased susceptibility of mice to infection with Listeria monocytogenes in the absence of interleukin-18
    Matthias Lochner
    Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
    Infect Immun 76:3881-90. 2008
    ..In contrast, control and IL-18-deficient mice showed no significant differences in their abilities to mount a protective L. monocytogenes-specific T-cell response...
  74. ncbi In situ imaging of the endogenous CD8 T cell response to infection
    Kamal M Khanna
    Department of Immunology, University of Connecticut, Farmington, CT 06030, U S A
    Science 318:116-20. 2007
    ..Thus, the ability to track endogenous immune responses has uncovered both distinct and overlapping mechanisms and anatomical locations driving primary and secondary immune responses...
  75. ncbi Antigen delivered by anthrax lethal toxin induces the development of memory CD8+ T cells that can be rapidly boosted and display effector functions
    Christine A Shaw
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 76:1214-22. 2008
    ..Finally, we demonstrated that mice that received prime-boost immunizations of LT-antigen proteins were more protected in a Listeria monocytogenes challenge model than mice that received only one immunization...
  76. ncbi Stimulation of enhanced CD8 T cell responses following immunization with a hyper-antigen secreting intracytosolic bacterial pathogen
    Megan J Smithey
    Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 180:3406-16. 2008
    ....
  77. ncbi Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation
    Ryan M Kelly
    Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota, Minneapolis 55455, USA
    Blood 111:5734-44. 2008
    ..Thus, KGF combined with androgen blockade represents a novel approach to restore thymic function and facilitates the rapid recovery of peripheral T-cell function after allogeneic BMT...
  78. ncbi Attenuated Listeria infection activates natural killer cell cytotoxicity to regress melanoma growth in vivo
    Hua Shen
    Department of Immunology and Host Defenses, Ehime University Graduate School of Medicine, Ehime, Japan
    Microbiol Immunol 52:107-17. 2008
    ..We demonstrated that the attenuated Lm entrance into the cytoplasm induces the production of type I IFN followed by the activation of NK cells, which is essential for the Lm-induced antitumor response...
  79. ncbi Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis
    Monika Sakowicz-Burkiewicz
    Institut fur Medizinische Mikrobiologie, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
    J Immunol 180:5601-12. 2008
    ....
  80. ncbi Animal model for infection with Listeria monocytogenes
    D H Busch
    Yale University, New Haven, Connecticut, USA
    Curr Protoc Immunol . 2001
    ..This infection induces MHC class I-restricted CD8(+) cytolytic T lymphocytes that clear infection and provide long-term immunity. This unit describes methods that can be used for in vitro expansion of L. monocytogenes-specific T cells...
  81. ncbi Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help
    R Grenningloh
    Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Scand J Immunol 67:594-602. 2008
    ..monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help...
  82. ncbi Simultaneous assessment of antigen-stimulated cytokine production and memory subset composition of memory CD8 T cells
    Ali Jabbari
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, USA
    J Immunol Methods 313:161-8. 2006
    ..Using this method, we directly identify differences in IL-2 production capacity by CD62L(hi)- and CD62L(lo)-expressing antigen-specific memory CD8 T cell populations...
  83. ncbi Cytosolic expression of SecA2 is a prerequisite for long-term protective immunity
    Eric Muraille
    Institut National de la Santé et de la Recherche Médicale E03 44, Groupe Avenir, Institut de Pharmacologie Moleculaire et Cellulaire, 06560 Valbonne, France
    Cell Microbiol 9:1445-54. 2007
    ....
  84. ncbi Distinct regulation of H2-M3-restricted memory T cell responses in lymph node and spleen
    Alexander Ploss
    Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 175:5998-6005. 2005
    ..These results may have important implications for prime-boost vaccination strategies...
  85. ncbi Protective immunosurveillance of the central nervous system by Listeria-specific CD4 and CD8 T cells in systemic listeriosis in the absence of intracerebral Listeria
    Lai-Yu Kwok
    , , , Mannheim, Germany
    J Immunol 169:2010-9. 2002
    ..Collectively, these data reveal a novel T cell-mediated pathway of active immunosurveillance of the CNS during bacterial infections...
  86. ncbi Perforin-deficient CD8+ T cells: in vivo priming and antigen-specific immunity against Listeria monocytogenes
    D W White
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City 52242, USA
    J Immunol 162:980-8. 1999
    ..Furthermore, the results show that reduced antilisterial resistance observed with polyclonal PO CD8+ T cells is a consequence of a deficiency in effector function and not a result of suboptimal CD8+ T cell priming...
  87. ncbi Response to Listeria monocytogenes in mice lacking MHC class Ia molecules
    M S Seaman
    Immunology Graduate Program, Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 162:5429-36. 1999
    ..Thus, class Ia-deficient animals have a CD8+ T cell repertoire capable of recognizing both class Ia and class Ib molecules and can generate protective immunity to LM...
  88. ncbi Cutting edge: protective cell-mediated immunity to Listeria monocytogenes in the absence of myeloid differentiation factor 88
    Sing Sing Way
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 171:533-7. 2003
    ..These results indicate that adaptive immune responses can be generated and provide protective immunity in the absence of MyD88...
  89. ncbi Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection
    S E D'Orazio
    Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:291-8. 2003
    ..monocytogenes challenge. These results suggest that even a limited number of class Ib MHC-restricted T cells are sufficient to generate the rapid recall response required for protection against secondary infection with L. monocytogenes...
  90. ncbi Defective CD8 T cell memory following acute infection without CD4 T cell help
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Science 300:339-42. 2003
    ..The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development...
  91. ncbi Tailoring host immune responses to Listeria by manipulation of virulence genes -- the interface between innate and acquired immunity
    Christian Peters
    Aventis Behring, Clinical Research and Development, 1020 First Avenue, King of Prussia, PA 19406, USA
    FEMS Immunol Med Microbiol 35:243-53. 2003
    ..We conclude that this mutant, L. monocytogenes DeltaactADeltaplcB, is at present the most promising mutant for a bacterial vaccine vector and is able to safely induce potent CD8(+) T cell-mediated immunity...
  92. ncbi Identification of four new members of the internalin multigene family of Listeria monocytogenes EGD
    S Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Infect Immun 65:1615-25. 1997
    ..The identity of such an aspect remains to be determined...
  93. ncbi CD8 T cell immunome analysis of Listeria monocytogenes
    Christian Kamm
    , , Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
    FEMS Immunol Med Microbiol 35:235-42. 2003
    ....
  94. ncbi Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma
    V P Badovinac
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City 52242, USA
    J Immunol 164:6444-52. 2000
    ..In addition, the results suggest the potential for perforin and IFN-gamma to regulate the magnitude of the CD8+ T cell response to infection...
  95. ncbi Ethanol consumption and the susceptibility of mice to Listeria monocytogenes infection
    J A Salerno
    Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois 60611-3010, USA
    Alcohol Clin Exp Res 25:464-72. 2001
    ..CONCLUSIONS: This study indicates that alcohol consumption may not always increase infectious disease progression...
  96. ncbi Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses
    Mischo Kursar
    Max Planck Institute for Infection Biology, Department of Immunology. Deutsches Rheumaforschungszentrum, Schumannstr. 21/22, 10117 Berlin, Germany
    J Exp Med 196:1585-92. 2002
    ..Down-modulation of CD8+ T cell responses during infection could prevent harmful consequences after eradication of the pathogen...
  97. ncbi gp96-peptide vaccination of mice against intracellular bacteria
    U Zugel
    Department of Immunology, University of Ulm, Germany
    Infect Immun 69:4164-7. 2001
    ..Immunization with gp96 may therefore represent a promising vaccination strategy against bacterial pathogens...
  98. ncbi Listeria monocytogenes infection overcomes the requirement for CD40 ligand in exogenous antigen presentation to CD8(+) T cells
    S E Hamilton
    Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 167:5603-9. 2001
    ..These data support a model in which DCs can be stimulated in vivo through signals other than CD40, becoming APC that can effectively stimulate CD8(+) T cell responses against exogenous Ags during infection...
  99. ncbi Mechanism of murine Vgamma1+ gamma delta T cell-mediated innate immune response against Listeria monocytogenes infection
    Goro Matsuzaki
    Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Eur J Immunol 32:928-35. 2002
    ....
  100. ncbi Organ-specific CD4+ T cell response during Listeria monocytogenes infection
    Mischo Kursar
    Max-Planck-Institute for Infection Biology, Berlin, Germany
    J Immunol 168:6382-7. 2002
    ..Our results show that kinetics and magnitude of the CD4(+) T cell response and the accumulation of CD4(+) memory T cells depend on the route of infection and are regulated in a tissue-specific way...
  101. ncbi Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB/c and C57BL/6 mice
    Tie Liu
    Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, Japan
    Infect Immun 70:6638-45. 2002
    ..Differences in reactivities of DC to microbial molecules through TLRs may be associated with susceptibility and resistance to Listeria infection in BALB/c and C57BL/6 mice...

Research Grants82

  1. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  2. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen Gregory; Fiscal Year: 2007
    ..Consequently, they should provide valuable insights that will enable the development of innovative strategies to improve treatment and to prevent the devastating consequences often associated with septicemia and sepsis. ..
  3. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen Gregory; Fiscal Year: 2009
    ..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..
  4. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen H Gregory; Fiscal Year: 2010
    ..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..
  5. FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATION
    Stephen Gregory; Fiscal Year: 2004
    ..abstract_text> ..
  6. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2006
    ..Our studies will shed light on the important interactions between innate immunity and adaptive T cell responses. ..
  7. Immunity to Intracellular Pathogens
    EMIL RAPHAEL UNANUE; Fiscal Year: 2010
    ..Studying the biochemical and cellular basis of such a protein will give us insights on how antigens are presented during microbial infection. ..
  8. Recombinant Lactobacillus as an Oral Mucosal Vaccine Against HIV-1
    Gregg Dean; Fiscal Year: 2009
    ..Studies proposed here will investigate strategies to engineer recombinant L. gasseri that can induce a protective immune response against HIV-1 via the oral mucosa. ..
  9. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2009
    ..abstract_text> ..
  10. Vertical transmission of Listeria monocytogenes
    Anna Bakardjiev; Fiscal Year: 2007
    ..The proposed research will provide important training which will prove crucial for the applicant when she becomes an independent physician scientist, her long-term goal. ..
  11. BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIV
    Gregg Dean; Fiscal Year: 2007
    ..Together these studies will elucidate the cellular mechanisms that underlie the innate immune defect and investigate potential molecular mechanisms. ..
  12. CC-chemokines in Listeria infection.
    Eric Pamer; Fiscal Year: 2007
    ....
  13. BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIV
    Gregg Dean; Fiscal Year: 2004
    ..ompounds. ..
  14. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2004
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..
  15. T LYMPHOCYTE RESPONSES TO LISTERIA INFECTION
    Eric Pamer; Fiscal Year: 2002
    ..These experiments will shed light on how the size of the T cell response to an epitope is determined in vivo and are likely to provide ideas for optimizing vaccines which elicit dominant, long term T lymphocyte responses. ..
  16. L. MONOCYTOGENES CLONAL GROUPS: ECOLOGY AND TRANSMISSION
    Martin Wiedmann; Fiscal Year: 2004
    ..4. Determine the phenotypes of L. monocytogenes clonal groups associated with specific environments and hosts and determine the genetic basis for phenotypes associated with a preference for specific habitats...
  17. TNF Mediated Immune Defense Against Listeria Infection
    Eric Pamer; Fiscal Year: 2007
    ....
  18. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2004
    ..This approach should offer a rational explanation for immunogenicity that avoids the empiricisms of results based only on T cell assays. ..
  19. LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLS
    NANCY ELIZABETH FREITAG; Fiscal Year: 2010
    ..The ultimate goal of the proposed work is to elucidate the regulatory pathways that enable bacterial survival within host cells, and the functional identification of additional bacterial factors that support replication within the host. ..
  20. LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLS
    NANCY ELIZABETH FREITAG; Fiscal Year: 2010
    ....
  21. LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLS
    Nancy Freitag; Fiscal Year: 2005
    ..This information is important towards better definition of the interactions that occur between host and pathogen during the process of infection. ..
  22. Etiologic studies on EMND: An animal model for ALS
    Hussni Mohammed; Fiscal Year: 2004
    ..Data obtained from these pilot studies will represent a major breakthrough towards the understanding of the mechanism of the motor neuron disease and lay the foundation for more thorough investigation. ..
  23. Host-pathogen Genetics Using Listeria and Drosophila
    Nancy Freitag; Fiscal Year: 2007
    ..abstract_text> ..
  24. ROLE OF ATP-BINDING CASSETTE TRANSPORTERS IN INNATE INTESTINAL DEFENSE
    Brien Neudeck; Fiscal Year: 2007
    ..Once this is accomplished, we can use this information to develop protective strategies that exploit these preexisting barriers to L. monocytogenes and potentially other pathogens. ..