listeria infections

Summary

Summary: Infections with bacteria of the genus LISTERIA.

Top Publications

  1. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
  2. pmc Intracellular gene expression profile of Listeria monocytogenes
    Som Subhra Chatterjee
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Infect Immun 74:1323-38. 2006
  3. ncbi Listeria monocytogenes: a multifaceted model
    Mélanie Hamon
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris 75015, France
    Nat Rev Microbiol 4:423-34. 2006
  4. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
  5. ncbi Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase
    M U Shiloh
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York 10021, USA
    Immunity 10:29-38. 1999
  6. ncbi Immune responses to Listeria monocytogenes
    Eric G Pamer
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 4:812-23. 2004
  7. pmc The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity
    Daniel A Portnoy
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    J Cell Biol 158:409-14. 2002
  8. ncbi Impaired immune and acute-phase responses in interleukin-6-deficient mice
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Nature 368:339-42. 1994
  9. pmc Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection
    Javier A Carrero
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:535-40. 2004
  10. ncbi Listeria: A foodborne pathogen that knows how to survive
    Megha Gandhi
    Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Int J Food Microbiol 113:1-15. 2007

Research Grants

Detail Information

Publications243 found, 100 shown here

  1. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
    ..Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen...
  2. pmc Intracellular gene expression profile of Listeria monocytogenes
    Som Subhra Chatterjee
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Infect Immun 74:1323-38. 2006
    ..monocytogenes in host cells. Overall, our study provides crucial insights into the strategy of intracellular survival and measures taken by L. monocytogenes to escape the host cell responses...
  3. ncbi Listeria monocytogenes: a multifaceted model
    Mélanie Hamon
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris 75015, France
    Nat Rev Microbiol 4:423-34. 2006
    ..Moreover, the vast amount of knowledge that has been gathered through in-depth comparative genomic analyses and in vivo studies makes L. monocytogenes one of the most well-studied bacterial pathogens...
  4. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
    ..These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection...
  5. ncbi Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase
    M U Shiloh
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York 10021, USA
    Immunity 10:29-38. 1999
    ..Their killing of S. typhimurium, E. coli, and attenuated Listeria was markedly diminished but demonstrable, establishing the existence of a mechanism of macrophage antibacterial activity independent of phox and NOS2...
  6. ncbi Immune responses to Listeria monocytogenes
    Eric G Pamer
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 4:812-23. 2004
    ..These studies, which are yielding one of the most comprehensive pictures of the 'battle' between host and microorganism, are reviewed here...
  7. pmc The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity
    Daniel A Portnoy
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    J Cell Biol 158:409-14. 2002
    ..Alteration in any of these processes dramatically reduces the ability of the bacteria to establish a productive infection in vivo...
  8. ncbi Impaired immune and acute-phase responses in interleukin-6-deficient mice
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Nature 368:339-42. 1994
    ..We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes...
  9. pmc Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection
    Javier A Carrero
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:535-40. 2004
    ..Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins...
  10. ncbi Listeria: A foodborne pathogen that knows how to survive
    Megha Gandhi
    Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901, USA
    Int J Food Microbiol 113:1-15. 2007
    ..Studies on the development of technologies to prevent and control L. monocytogenes contamination in foods and food processing facilities are also discussed...
  11. ncbi Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    Koichi S Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 307:731-4. 2005
    ..The Nod2 protein is thus a critical regulator of bacterial immunity within the intestine, providing a possible mechanism for Nod2 mutations in CD...
  12. ncbi The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    Yun Gi Kim
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunity 28:246-57. 2008
    ..monocytogenes was critically dependent on Nod1 and Nod2 when mice were previously stimulated with lipopolysaccharide or E. coli. Thus, Nod1 and Nod2 are important for microbial recognition and host defense after TLR stimulation...
  13. pmc The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria
    Tina Rajabian
    Department of Molecular Genetics, University of Toronto Toronto, Ontario, M5S 1A8, Canada
    Nat Cell Biol 11:1212-8. 2009
    ..Collectively, our results suggest that InlC promotes bacterial dissemination by relieving cortical tension, thereby enhancing the ability of motile bacteria to deform the plasma membrane into protrusions...
  14. pmc Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
    ..Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense...
  15. pmc Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes
    Victoria Auerbuch
    Department of Molecular and Cell Biology, 508 Barker Hall, University of California, Berkeley, 94720, USA
    J Exp Med 200:527-33. 2004
    ..The results of this study suggest that L. monocytogenes might be exploiting an innate antiviral response to promote its pathogenesis...
  16. pmc Construction and characterization of Listeria monocytogenes mutants with in-frame deletions in the response regulator genes identified in the genome sequence
    Tatjana Williams
    Kompetenzzentrum PathoGenoMik, Theodor Boveri Institut für Biowissenschaften der Universität Würzburg Biozentrum, Am Hubland, 97074 Wurzburg, Germany
    Infect Immun 73:3152-9. 2005
    ..The mutant carrying a deletion in the ortholog of the Bacillus subtilis response regulator gene degU showed a clearly reduced virulence in mice, indicating that DegU is involved in the regulation of virulence-associated genes...
  17. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  18. ncbi Exposure of Listeria monocytogenes within an epidemic caused by butter in Finland
    R Maijala
    Risk Analysis, National Veterinary and Food Research Institute, Helsinki, Finland
    Int J Food Microbiol 70:97-109. 2001
    ..Due to the susceptibility of hospital patients, special care must be taken in order to avoid even low levels of L. monocytogenes in food served...
  19. pmc Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
  20. ncbi Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection
    C Pope
    Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 166:3402-9. 2001
    ..Overall, the results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses...
  21. pmc Cytosolic entry controls CD8+-T-cell potency during bacterial infection
    Keith S Bahjat
    Cerus Corporation, 2411 Stanwell Drive, Concord, CA 94520, USA
    Infect Immun 74:6387-97. 2006
    ..These results reveal a crucial role for phagosomal escape, not for delivery of antigen to the class I major histocompatibility complex pathway but for establishing the appropriate cellular context during CD8+-T-cell priming...
  22. pmc Listeria pathogenesis and molecular virulence determinants
    J A Vazquez-Boland
    Grupo de Patogénesis Molecular Bacteriana, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
    Clin Microbiol Rev 14:584-640. 2001
    ....
  23. ncbi Unidirectional development of CD8+ central memory T cells into protective Listeria-specific effector memory T cells
    Katharina M Huster
    Clinical Cooperation Group Antigen Specific Immunotherapy, GSF National Research Center of Environment and Health and Technical University Munich, Germany
    Eur J Immunol 36:1453-64. 2006
    ..m.) nor T(EC) (by systemic co-administration of CpG during primary infection) conferred substantial long-term protective immunity. These findings have important implications for the design of more effective T cell-based vaccines...
  24. pmc Molecular epidemiology of an outbreak of febrile gastroenteritis caused by Listeria monocytogenes in cold-smoked rainbow trout
    M K Miettinen
    Department of Food and Environmental Hygiene, 00014 University of Helsinki, Finland
    J Clin Microbiol 37:2358-60. 1999
    ..L. monocytogenes isolates from the incriminated fish product lot and the stool samples were all of serotype 1/2a and were indistinguishable by pulsed-field gel electrophoresis employing AscI and SmaI...
  25. ncbi A molecular marker for evaluating the pathogenic potential of foodborne Listeria monocytogenes
    Christine Jacquet
    Laboratoire des Listeria, Centre National de Référence des Listeria, World Health Organization Collaborating Center for Foodborne Listeriosis, Institut Pasteur, Paris, France
    J Infect Dis 189:2094-100. 2004
    ..The relevance of these findings for humans is challenged by the observation that some L. monocytogenes isolates express a truncated nonfunctional form of internalin...
  26. ncbi Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model
    Marc Lecuit
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Biol Chem 282:15065-72. 2007
    ..Together, these studies establish that hly, rather than bacterial invasion of the lamina propria mediated by InlA, is a dominant determinant of the intensity of the host response to L. monocytogenes infection via the oral route...
  27. pmc Differentiation of the major Listeria monocytogenes serovars by multiplex PCR
    Michel Doumith
    Laboratoire des Listeria Centre National de Référence des Listeria World Health Organization Collaborating Center for Foodborne Listeriosis, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Clin Microbiol 42:3819-22. 2004
    ..The PCR test, which constitutes a rapid and practical alternative to laborious classical serotyping, was successfully evaluated with 222 Listeria strains...
  28. pmc Listeria monocytogenes infection in Israel and review of cases worldwide
    Yardena Siegman-Igra
    Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    Emerg Infect Dis 8:305-10. 2002
    ..The common clinical syndromes in these patients were primary bacteremia (47%) and meningitis (28%). The crude case-fatality rate in this group was 38%, with a higher death rate in immunocompromised patients...
  29. pmc Ecology and transmission of Listeria monocytogenes infecting ruminants and in the farm environment
    K K Nightingale
    Department of Food Science, 412 Stocking Hall, Cornell University, Ithaca, NY 14853, USA
    Appl Environ Microbiol 70:4458-67. 2004
    ..monocytogenes, including subtypes linked to human listeriosis cases and outbreaks, and (iv) L. monocytogenes subtypes may differ in their abilities to infect animals and to survive in farm environments...
  30. ncbi TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
    ..In summary, these data help clarify the biologic roles of p55 and p75 in mediating and modulating the biologic activity of TNF and provide genetic evidence for an antagonistic role of p75 in vivo...
  31. ncbi Listeria monocytogenes in multiple habitats and host populations: review of available data for mathematical modeling
    Renata Ivanek
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Foodborne Pathog Dis 3:319-36. 2006
    ..monocytogenes load and transmission in hosts and habitats associated with these anthropogenic practices would reduce human exposure and consequently human listeriosis...
  32. pmc The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production
    Tina Mahieu
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology and Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Proc Natl Acad Sci U S A 103:2292-7. 2006
    ..In contrast to TLR4-deficient mice, SPRET/Ei mice resist both LPS and sepsis induced with Klebsiella pneumoniae...
  33. ncbi Molecular characterization of the arginine deiminase system in Listeria monocytogenes: regulation and role in acid tolerance
    Sheila Ryan
    Department of Microbiology, University College Cork, Cork, Ireland
    Environ Microbiol 11:432-45. 2009
    ..Finally, using the murine model of infection, we have established a role for the ADI system in the virulence of L. monocytogenes...
  34. pmc In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection
    Ana Camejo
    IBMC, Instituto de Biologia Molecular e Celular, Group of Molecular Microbiology, Universidade do Porto, Porto, Portugal
    PLoS Pathog 5:e1000449. 2009
    ..monocytogenes virulence factors, including an LPXTG surface protein, suggesting a role for S-layer glycoproteins and for cadmium efflux system in Listeria virulence...
  35. ncbi Novel functions of type I interferons revealed by infection studies with Listeria monocytogenes
    Silvia Stockinger
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Dr Bohr Gasse 9 4, A 1030 Vienna, Austria
    Immunobiology 213:889-97. 2008
    ..These in turn sensitise the Listeria host to lethal sequelae of infection with these bacteria. Here, we summarise recent findings on the production and biological effects of type I IFN in the course of L. monocytogenes infection...
  36. pmc Listeria monocytogenes traffics from maternal organs to the placenta and back
    Anna I Bakardjiev
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    PLoS Pathog 2:e66. 2006
    ..Once colonized, the placenta becomes a nidus of infection resulting in massive reseeding of maternal organs, where L. monocytogenes cannot be cleared until trafficking is interrupted by expulsion of the infected placental tissues...
  37. ncbi Multistate outbreak of Listeriosis linked to turkey deli meat and subsequent changes in US regulatory policy
    Sami L Gottlieb
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 42:29-36. 2006
    ..Between July and October 2002, an uncommon strain of L. monocytogenes caused an outbreak of listeriosis in 9 states...
  38. ncbi Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection
    Anna I Bakardjiev
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    J Infect Dis 191:1889-97. 2005
    ..We concluded that cell-to-cell spread facilitates maternal-to-fetal transmission. Furthermore, the placenta provides a protective niche for growth of L. monocytogenes...
  39. ncbi Involvement of receptor-interacting protein 2 in innate and adaptive immune responses
    Arnold i Chin
    Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Nature 416:190-4. 2002
    ..Our data reflect requirements for Rip2 in multiple pathways regulating immune and inflammatory responses...
  40. ncbi Hospital-acquired listeriosis
    J C Graham
    Clinical Microbiology Department, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, UK
    J Hosp Infect 51:136-9. 2002
    ..We discuss the difficulties in preventing food-borne listeriosis in the hospital setting...
  41. pmc Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection
    David Torres
    CNRS, Laboratoire de Génétique expérimentale et moléculaire GEM2358, F 45071 Orleans cedex 2, France
    Infect Immun 72:2131-9. 2004
    ..Therefore, the present data demonstrate a role for TLR2 in the control of Listeria infection, but other MyD88-dependent signals may contribute to host resistance...
  42. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
  43. ncbi Quantitative risk assessment of Listeria monocytogenes in ready-to-eat foods: the FAO/WHO approach
    J Rocourt
    World Health Organization, Food Safety Programme, Avenue Apia, 1211, Geneva 27, Switzerland
    FEMS Immunol Med Microbiol 35:263-7. 2003
    ..Preliminary data indicate that eliminating the higher dose levels at the time of consumption has a large impact on the number of predicted cases...
  44. pmc Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice
    B Lu
    Integrated Program of Molecular, Cellular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 95:8233-8. 1998
    ..These results demonstrate that the IFN-gammaR2 is essential for IFN-gamma-mediated immune responses in vivo...
  45. ncbi Foodborne listeriosis
    W F Schlech
    Division of Infectious Diseases, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    Clin Infect Dis 31:770-5. 2000
    ..Microbial virulence factors distinguishing environmental strains of L. monocytogenes from invasive strains causing foodborne illness and host factors promoting human infection remain incompletely understood...
  46. ncbi Listeria monocytogenes as a probe of immune function
    Oleg Garifulin
    Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Brief Funct Genomic Proteomic 4:258-69. 2005
    ..monocytogenes infection...
  47. pmc A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production
    M Neighbors
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Incorporated, Palo Alto, CA 94304, USA
    J Exp Med 194:343-54. 2001
    ..Tumor necrosis factor (TNF) is also a major player in the resolution of Listeria infections and is suggested to have more global effects than can be explained by the induction of IFN-gamma alone...
  48. ncbi Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes
    H W Mittrucker
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 167:5620-7. 2001
    ..However, Ag-specific CD8(+) T cells generated in the absence of CD28 differentiated into normal effector and memory T cells...
  49. pmc Growth, virulence, and immunogenicity of Listeria monocytogenes aro mutants
    Jochen Stritzker
    Lehrstuhl für Mikrobiologie am Biozentrum der Universität Würzburg, Wurzburg, Germany
    Infect Immun 72:5622-9. 2004
    ....
  50. ncbi Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002
    ..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
  51. ncbi Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
    ....
  52. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  53. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
    ....
  54. ncbi Auto, a surface associated autolysin of Listeria monocytogenes required for entry into eukaryotic cells and virulence
    Didier Cabanes
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 51:1601-14. 2004
    ..During infection, the autolytic activity of Auto may also be critical. Auto appears thus as a novel type of L. monocytogenes virulence factor...
  55. ncbi Listeria monocytogenes: clinical and experimental update
    Edward J Wing
    Department of Medicine, Brown University Medical School, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Infect Dis 185:S18-24. 2002
    ....
  56. pmc Innate and adaptive immune responses to Listeria monocytogenes: a short overview
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Microbes Infect 9:1208-15. 2007
    ..monocytogenes infection. Both the innate and adaptive immune systems are crucial to the recognition and elimination of this pathogen from the host...
  57. pmc Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes
    Celine A Nadon
    Department of Food Science, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 70:3948-52. 2002
    ..monocytogenes. Thus, the alternative sigma factor sigma(B) contributes to virulence in L. monocytogenes...
  58. ncbi The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes
    O Gaillot
    INSERM U411, Centre Hospitalo Universitaire Necker Enfants Malades, 156, rue de Vaugirard, 75730 Paris Cedex 15, France
    Mol Microbiol 35:1286-94. 2000
    ..These results suggest that ClpP is involved in the rapid adaptive response of intracellular pathogens during the infectious process...
  59. ncbi Listeria monocytogenes, a unique model in infection biology: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Microbes Infect 10:1041-50. 2008
    ..Together, Listeria, after being recognized as a powerful tool in immunology, now appears as one of the most insightful models in infection biology...
  60. ncbi Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses
    Kathryn E Foulds
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:1528-32. 2002
    ..Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells...
  61. pmc Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis
    C Cheers
    Infect Immun 19:755-62. 1978
    ..There was no difference in the response of males and females. In all studies, the powerful overriding influence of the C57B1 genome was evident...
  62. pmc Constitutive Activation of the PrfA regulon enhances the potency of vaccines based on live-attenuated and killed but metabolically active Listeria monocytogenes strains
    Peter Lauer
    Anza Therapeutics, Inc, Concord, CA 94520, USA
    Infect Immun 76:3742-53. 2008
    ..These results form the basis of a rationale for including the prfA(G155S) allele in future live-attenuated or KBMA L. monocytogenes vaccines advanced to the clinical setting...
  63. ncbi Feedback regulation of pathogen-specific T cell priming
    Phillip Wong
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Immunity 18:499-511. 2003
    ..Our studies demonstrate a feedback mechanism that limits the duration of effective in vivo antigen presentation, thereby modulating T cell responses by temporally restricting recruitment of naive T cells into the immune response...
  64. pmc Listeria monocytogenes flagella are used for motility, not as adhesins, to increase host cell invasion
    Heather S O'Neil
    Department of Microbiology and Immunology, VMC Rm C5 169, Cornell University, Ithaca ny 14853 6401, USA
    Infect Immun 74:6675-81. 2006
    ..This difference is also reflected in invasion of the liver 12 h later, suggesting that flagellum-mediated motility enhances L. monocytogenes infectivity soon after bacterial ingestion in vivo...
  65. pmc Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
    Katharina M Huster
    Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 101:5610-5. 2004
    ....
  66. ncbi Extracellular replication of Listeria monocytogenes in the murine gall bladder
    Jonathan Hardy
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:851-3. 2004
    ..The data suggest that L. monocytogenes may be carried in the human gall bladder...
  67. ncbi Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
    J Rothe
    Department of Biology, Hoffmann La Roche Ltd, Basel, Switzerland
    Nature 364:798-802. 1993
    ..The increased susceptibility of Tnfr1(0)/Tnfr1(0) mutant mice to infection with the facultative intracellular bacterium Listeria monocytogenes indicates an essential role of TNF in nonspecific immunity...
  68. ncbi Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    K Pfeffer
    Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Canada
    Cell 73:457-67. 1993
    ..In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection. Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors...
  69. pmc Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia
    S A Dalrymple
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, California 94304, USA
    Infect Immun 63:2262-8. 1995
    ..Additionally, these data show a promising therapeutic potential for rIL-6 administration during opportunistic infection...
  70. ncbi Listeriosis during pregnancy: a case series and review of 222 cases
    Eleftherios Mylonakis
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Medicine (Baltimore) 81:260-9. 2002
  71. pmc Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically
    Terri S Hamrick
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Infect Immun 71:5202-9. 2003
    ....
  72. ncbi Reduced apoptosis and ameliorated listeriosis in TRAIL-null mice
    Shi Jun Zheng
    Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5652-8. 2004
    ..Lymphoid and myeloid cell death was significantly inhibited in TRAIL-/- mice, which led to marked enlargement of the spleen. These results establish a critical role for TRAIL in apoptosis during listeriosis...
  73. pmc GILT is a critical host factor for Listeria monocytogenes infection
    Reshma Singh
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06250 8011, USA
    Nature 455:1244-7. 2008
    ..In addition, purified GILT activates recombinant LLO, facilitating membrane permeabilization and red blood cell lysis. The data show that GILT is a critical host factor that facilitates L. monocytogenes infection...
  74. pmc Nonspecific early protective immunity in Francisella and Listeria infections can be dependent on lymphocytes
    K L Elkins
    Laboratory of Mycobacteria, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA
    Infect Immun 66:3467-9. 1998
    ..Since sublethal infection with either LVS or L. monocytogenes protects against heterologous lethal challenge, this early protection is nonspecific...
  75. ncbi Human listeriosis and animal models
    Marc Lecuit
    Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1216-25. 2007
    ..Finally, we present some of the critical determinants for the choice of an appropriate animal model to study human listeriosis...
  76. ncbi Surveillance of listeria infections in Europe
    H De Valk
    Institut de Veille Sanitaire, Saint Maurice, France
    Euro Surveill 10:251-5. 2005
    ..In 2002, a survey was carried out to assess the need for and the feasibility of a European network on listeria infections in humans...
  77. ncbi Development of a multilocus variable-number of tandem repeat typing method for Listeria monocytogenes serotype 4b strains
    Satoko Miya
    Department of Food Science and Technology, Faculty of Marine Science, Tokyo University of Marine Science and Technology, 4 5 7 Konan, Minato ku, Tokyo 108 8477, Japan
    Int J Food Microbiol 124:239-49. 2008
    ..Use of MLVA may thus be recommended for subtyping of serotype 4b isolates, including as a secondary more discriminatory subtyping method that could be used after initial isolate characterization by PFGE or ribotyping...
  78. ncbi Exploration of host-pathogen interactions using Listeria monocytogenes and Drosophila melanogaster
    Bryce E Mansfield
    Department of Pathobiology, University of Washington, USA
    Cell Microbiol 5:901-11. 2003
    ..monocytogenes infection...
  79. pmc Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis
    T Fehr
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Exp Med 185:921-31. 1997
    ....
  80. pmc Construction of a multiple fluorescence labelling system for use in co-invasion studies of Listeria monocytogenes
    Jens B Andersen
    Danish Institute for Food and Veterinary Research, Department of Microbiological Food Safety, Mørkhøj Bygade 19, 2860 Søborg, Denmark
    BMC Microbiol 6:86. 2006
    ..One way to circumvent this problem is to carry out virulence studies as competition assays between 2 or more strains. This, however, requires invasion-neutral markers that enable easy discrimination between the different strains...
  81. pmc Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection
    Janelle S Ayres
    Department of Microbiology and Immunology, University of Illinois, Chicago, Illinois 60612, USA
    Genetics 178:1807-15. 2008
    ..By using a whole-animal model and screening for host survival, we revealed genes involved in physiologies different from those that were found in previous screens, which all had defects in defensive immune signaling...
  82. ncbi Incidence of foodborne illnesses reported by the foodborne diseases active surveillance network (FoodNet)-1997. FoodNet Working Group
    D J Wallace
    Centers for Disease Control and Prevention, Division of Bacterial and Mycotic Diseases, National Center for Infectious Disease, Foodborne and Diarrheal Diseases Branch, Atlanta, Georgia 30333 USA
    J Food Prot 63:807-9. 2000
    ..More data over more years are needed to assess if observed variations in incidence reflect yearly fluctuations or true changes in the burden of foodborne illness...
  83. ncbi Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI
    R Endres
    Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Federal Republic of Germany
    Immunity 7:419-32. 1997
    ....
  84. ncbi Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
    T Tanaka
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 80:353-61. 1995
    ..We also demonstrate that NF-IL6 is essential for the induction of G-CSF in macrophages and fibroblasts...
  85. pmc Novel luciferase reporter system for in vitro and organ-specific monitoring of differential gene expression in Listeria monocytogenes
    Peter A Bron
    Alimentary Pharmabiotic Centre, University College Cork, Western Road, Cork, Ireland
    Appl Environ Microbiol 72:2876-84. 2006
    ..These experiments clearly established the effectiveness of pPL2lux as a quantitative reporter system for real-time, noninvasive evaluation of gene expression in L. monocytogenes...
  86. ncbi Molecular determinants of Listeria monocytogenes virulence
    Olivier Dussurget
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, 75015 Paris, France
    Annu Rev Microbiol 58:587-610. 2004
    ..This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis...
  87. ncbi Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes
    S Bregenholt
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, Paris, France
    J Immunol 166:1871-6. 2001
    ..monocytogenes infection, and that in their absence alphabeta T cells are able to mediate the early IFN-gamma production required for both innate and adaptive immunity...
  88. pmc Plasma cytokine response in mice with bacterial infection
    M Abram
    Department of Microbiology, Medical Faculty, University of Rijeka, Croatia
    Mediators Inflamm 9:229-34. 2000
    ..Exposure to microorganisms elicts the production of cytokines. These soluble factors enhance several innate immune functions and regulate the ensuing specific immune response aimed at limiting the spread of infection...
  89. pmc A specific gene expression program triggered by Gram-positive bacteria in the cytosol
    Ramona L McCaffrey
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
    Proc Natl Acad Sci U S A 101:11386-91. 2004
    ..Further characterization of cytosolic surveillance pathway(s) and their points of convergence with TLR- and IFN-dependent pathways will enhance our understanding of the means by which mammals detect and respond to pathogens...
  90. ncbi A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier
    M Lecuit
    , Station Centrale de Microscopie Electronique, Institut Pasteur, 75724 Paris Cedex 15, France
    Science 292:1722-5. 2001
    ..These results illustrate how relevant animal models for human infections can be generated...
  91. ncbi Genetic linkage of resistance to Listeria monocytogenes with macrophage inflammatory responses
    M M Stevenson
    J Immunol 127:402-7. 1981
    ....
  92. ncbi Optimization of green fluorescent protein expression vectors for in vitro and in vivo detection of Listeria monocytogenes
    N Fortinea
    Laboratoire de Microbiologie, Institut national de la santé et de la recherche médicale U 411, Faculte de Medecine Necker Enfants Malades, Paris, France
    Res Microbiol 151:353-60. 2000
    ..Listeria cells harboring pNF8 were readily detected in both cultured macrophages and tissue sections. Constructed GFP vectors did not affect the virulence of L. monocytogenes in a murine model of infection...
  93. ncbi Pathogen-specific CD8 T cell responses are directly inhibited by IL-10
    Partha Sarathi Biswas
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 179:4520-8. 2007
    ..Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses...
  94. ncbi Differential expansion, activation and effector functions of conventional and plasmacytoid dendritic cells in mouse tissues transiently infected with Listeria monocytogenes
    Miguel A Tam
    Department of Clinical Immunology, Goteborg University, Goteborg, Sweden
    Cell Microbiol 8:1172-87. 2006
    ..In contrast, IL-12 was induced only with wild-type bacteria. These data provide new insight into the relative abundance and function of distinct CD11c-expressing populations during the early stage of Listeria infection...
  95. ncbi Priming of memory but not effector CD8 T cells by a killed bacterial vaccine
    G Lauvau
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 294:1735-9. 2001
    ..Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity...
  96. ncbi Two consecutive nationwide outbreaks of Listeriosis in France, October 1999-February 2000
    H De Valk
    Institut de Veille Sanitaire, St Maurice, France
    Am J Epidemiol 154:944-50. 2001
    ..monocytogenes strains to allow early detection and separate investigation of different clusters...
  97. ncbi Listeria monocytogenes internalins bind to the human intestinal mucin MUC2
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, QLD, 4101, Australia
    Arch Microbiol 190:101-4. 2008
    ..We report here that the internalin domain of the InlJ protein also bound MUC2, suggesting that an internalin domain is sufficient to bind to MUC2...
  98. pmc Listeria monocytogenes mutants that fail to compartmentalize listerolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses
    Ian J Glomski
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Infect Immun 71:6754-65. 2003
    ..We concluded that L. monocytogenes controls the cytolytic activity of LLO to maintain its nutritionally rich intracellular niche and avoid extracellular defenses of the host...
  99. ncbi The specific and essential role of MAVS in antiviral innate immune responses
    Qinmiao Sun
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Immunity 24:633-42. 2006
    ..These results provide the in vivo evidence that the cytosolic viral signaling pathway through MAVS is specifically required for innate immune responses against viral infection...
  100. ncbi Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma
    V P Badovinac
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    Science 290:1354-8. 2000
    ..Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules...
  101. pmc Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin
    Marc Lecuit
    Unité des Interactions Bactéries Cellules and Unité d Histotechnologie et Pathologie, Institut Pasteur, Paris 75015, France
    Proc Natl Acad Sci U S A 101:6152-7. 2004
    ..monocytogenes to target and cross the placental barrier. Such a ligand-receptor interaction allowing a pathogen to specifically cross the placental villous trophoblast barrier has not been reported previously...

Research Grants62

  1. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  2. FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATION
    Stephen Gregory; Fiscal Year: 2004
    ..abstract_text> ..
  3. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen H Gregory; Fiscal Year: 2010
    ..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..
  4. L. MONOCYTOGENES CLONAL GROUPS: ECOLOGY AND TRANSMISSION
    Martin Wiedmann; Fiscal Year: 2004
    ..4. Determine the phenotypes of L. monocytogenes clonal groups associated with specific environments and hosts and determine the genetic basis for phenotypes associated with a preference for specific habitats...
  5. RESEARCH TRAINING IN INFECTIOUS DISEASES
    Eric Pamer; Fiscal Year: 2008
    ..A curriculum of seminars, journal clubs, lab meetings and formal courses has been developed for fellows performing laboratory-based research. [unreadable] [unreadable]..
  6. Interacton of HIV with Toll-like Receptors
    Gregg Dean; Fiscal Year: 2005
    ..Through these studies we will learn if HIV/TLR interaction contribute to the immunodeficiency caused by HIV-1. ..
  7. Recombinant Listeria: A Biologic Vaccine Vector For FIV
    Gregg Dean; Fiscal Year: 2004
    ..These studies will be performed in the FIV/cat model that allows challenge by vaginal exposure to cell-associated and cell-free virus. ..
  8. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  9. T CELL AUTOIMMUNITY
    Emil Unanue; Fiscal Year: 2007
    ..Murphy proposes a range of molecular and biological researches on this novel protein, including examining its role in a series of autoimmunities. ..
  10. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric G Pamer; Fiscal Year: 2010
    ..abstract_text> ..
  11. CYTOKINE RESPONSE IN FIV AND SIV IMMUNODEFICIENCY
    Gregg Dean; Fiscal Year: 2002
    ..ft. of laboratory space, startup funds, access to the central equipment laboratory, and three years of support for a technical assistant. ..
  12. In vivo significance of T-reg cells during FIV infection
    Gregg Dean; Fiscal Year: 2006
    ..Results from these studies will provide a clinical understanding of Treg function in HIV infection and will guide future approaches to modulate Treg function. ..
  13. EPITOPE DELIVERY, IMMUNODOMINANCE AND VACCINE EFFICACY
    H G Bouwer; Fiscal Year: 2003
    ..abstract_text> ..
  14. BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIV
    Gregg A Dean; Fiscal Year: 2010
    ..Together these studies will elucidate the cellular mechanisms that underlie the innate immune defect and investigate potential molecular mechanisms. ..
  15. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2006
    ..Our studies will shed light on the important interactions between innate immunity and adaptive T cell responses. ..
  16. Vertical transmission of Listeria monocytogenes
    Anna Bakardjiev; Fiscal Year: 2007
    ..The proposed research will provide important training which will prove crucial for the applicant when she becomes an independent physician scientist, her long-term goal. ..
  17. STUDIES OF ANTIGEN STIMULATION
    Emil Unanue; Fiscal Year: 2009
    ..abstract_text> ..
  18. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2004
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..
  19. New attenuated anthrax vaccine
    Hao Shen; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  20. The Basis of Functional Variation in Gamma/Delta T cells
    REBECCA O BRIEN; Fiscal Year: 2009
    ..We will also examine the importance to disease outcome of the ability of each subset to produce particular cytokines, induce the death of other cells, and undergo apoptosis. ..
  21. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ....
  22. CD8+T cell effector mechansisms against L. monocytogenes
    John Harty; Fiscal Year: 2007
    ..Aim-3. Investigate the mechanisms responsible for prolonged contraction of CD8+ T cells during the secondary response to infection. ..
  23. IMMUNE POTENTIAL OF ANIMAL LACKING CLASS IA MOLECULES
    JAMES M FORMAN; Fiscal Year: 2010
    ..In summary, this proposal will add important new information on how CDS T cells function in the innate immune response against intracellular pathogens. ..
  24. CTL pathogenesis after infection of vaccinated host
    John Harty; Fiscal Year: 2009
    ..Aim 3. Analyze CD8+ T cell and pathogen parameters that determine the outcome of LCMV infection in vaccinated PKO mice. Aim 4. Determine if vaccination-associated mortality extends to other immunodeficiencies or pathogens. ..
  25. Cross-Priming Mechanisms Induced by Microbial Products
    Sandip Datta; Fiscal Year: 2007
    ....
  26. Cellular Immune Surveillance of Intracellular bacteria
    Hao Shen; Fiscal Year: 2008
    ..abstract_text> ..
  27. VIRUS INDUCED IMMUNOPATHOLOGY
    Raymond Welsh; Fiscal Year: 2008
    ..SPECIFIC AIM #4. To determine the basis for the deficiency of virus-specific T cells in the homeostatic reconstitution of lymphopenic environments. ..
  28. Screen for Small Molecule Compounds that Modulate the Transcriptional Activity of
    Dan Littman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Properties of Metals May Govern Toxicities in the Lungs
    Mitchell Cohen; Fiscal Year: 2006
    ..By establishing if certain properties of metals are more relevant to toxicity than others, this may provide Investigators a needed basis to preempt use of some metal ions/complexes in metallopharmaceuticals. [unreadable] [unreadable]..
  30. Escape of Bacillus anthracis from the phagsome
    Howard Goldfine; Fiscal Year: 2004
    ..abstract_text> ..
  31. INDUCTION OF GAMMA/DELTA T CELLS BY MICROBIAL PRODUCTS
    H Ziegler; Fiscal Year: 2005
    ..The regulatory role of gamma/delta T cells in the production of pro-inflammatory cytokines will be studied. An attempt will be made to determine the function, receptor specificity, and activation requirements of gamma/delta T cells. ..
  32. IMMUNOGENICITY OF HIV PROTEINS DELIVERED BY LIVE VECTOR
    Yvonne Paterson; Fiscal Year: 2004
    ..These studies will start in year 2 of the proposal. The hypothesis of this aim is that the attenuated strains will as effective as wild-type Listeria in delivering SHIV antigens to the immune system. ..
  33. ANTIGEN PRESENTATION BY CLASS IB MOLECULE, QA-1
    James Forman; Fiscal Year: 2004
    ..If this occurs, we will then examine the processing and presentation of these viral encoded Qdm epitopes. ..
  34. T CELL TURNOVER AND THE ROLE OF CYTOKINES
    Jonathan Sprent; Fiscal Year: 2004
    ....
  35. RAGE and a Novel Tumor Axis
    Ann Schmidt; Fiscal Year: 2005
    ....
  36. Acquisition of High Speed Cell Sorter
    Dan Littman; Fiscal Year: 2002
    ..We believe that the availability of this powerful machine on our campus will elicit new exciting research projects from a variety of scientists working in the fields of cancer, immunology, and animal development. ..
  37. Bacterial vector vaccine: Her-2/neu expressing tumors
    Yvonne Paterson; Fiscal Year: 2005
    ..This work will demonstrate the utility of the L. monocytogenes-based vaccines, thus setting the stage for further development of a breast cancer therapeutic that can be used in humans. ..
  38. ACTIN BASED MOTILITY OF A BACTERIAL PATHOGEN
    Julie Theriot; Fiscal Year: 2009
    ..abstract_text> ..
  39. Manipulationg MINOR to extend DC lifespan and function
    Katharine Whartenby; Fiscal Year: 2009
    ..The goals of the proposed studies are to further investigate the function of this gene and to evaluate the effect of manipulating its expression in improving tumor vaccines. ..
  40. IMMUNITY AND VIRUS DISEASE
    Raymond Welsh; Fiscal Year: 2003
    ..By manipulating this highly defined LCMV model in vivo, fundamental concepts concerning immunoregulation and immune deficiencies applicable to human viral infections should be obtained. ..
  41. Immunotherapeutic strategies for breast cancer
    YVONNE J PATERSON; Fiscal Year: 2010
    ....
  42. Accelerated CD8 T cell memory after DC vaccination
    John T Harty; Fiscal Year: 2010
    ..Aim 3. Determine if accelerated memory and prime-boost after DC immunization improves immunotherapy against established tumors and protection against malaria and leishmaniasis. ..
  43. Use of host derived lipoate by Listeria monocytogenes
    MARY O RIORDAN; Fiscal Year: 2009
    ..In addition, the characterization of Lm mutants that are defective in intracellular growth will provide new candidates for live vaccine development and may identify new targets for anti-microbial therapeutics. ..
  44. Surface protein dynamics in live bacterial pathogens
    Julie A Theriot; Fiscal Year: 2010
    ..abstract_text> ..
  45. Role of inflammation in manganese-induced neurotoxicity
    NIKOLAY FILIPOV; Fiscal Year: 2004
    ..The long-term goal of the proposed studies is to understand the role of microglia and environmental contaminants in neurodegenerative diseases. ..
  46. THYMUS AND CENTRAL TOLERANCE
    Jonathan Sprent; Fiscal Year: 2003
    ..Resolving these questions will shed light on the basic mechanisms involved in self/non-self discrimination, the induction of autoimmune disease and the immune responses to neoplastic cells. ..
  47. Identifying Ligands with Soluble Gamma/Delta TCRs
    REBECCA O BRIEN; Fiscal Year: 2006
    ..3 sTCR. The backup approach involves generation of ligand specific mAbs, identified by their ability to block sTCR/ligand binding, as reagents to affinity-purify the ligand. ..
  48. CELLULAR FACTORS REQUIRED FOR HIV ENTRY
    Dan Littman; Fiscal Year: 2007
    ..The results of these studies should provide insight into[unreadable] the complex mechanism of HIV entry and may suggest novel approaches for[unreadable] interfering with the earliest step in the HIV life cycle.[unreadable]..
  49. Ethanol-fed, CpG-treated mice: Listeria susceptibility
    Nancy Ray; Fiscal Year: 2005
    ..These studies could lead to treatments for protecting alcoholic patients from intracellular bacterial infections such as those caused by L. monocytogenes or Mycobacterium tuberculosis (TB). ..
  50. REGULATION OF NATURAL KILLER CELLS
    Raymond Welsh; Fiscal Year: 2005
    ..This work should clarify how these effector systems act and interact to rid the host of infectious agents and tumors. ..
  51. C.elegans as a model system forC.neoformans pathogenesis
    Eleftherios Mylonakis; Fiscal Year: 2007
    ..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
  52. Spontaneous Corneal Inflammation in gd T cell absence
    REBECCA O BRIEN; Fiscal Year: 2005
    ..In addition, we will carryout experiments designed to examine whether the disease is autoimmune, results from bacterial infection, or stems from damage caused by a chemical released from dirty cage litter. ..
  53. MURINE MODEL SYSTEM FOR HIV PATHOGENESIS
    Dan Littman; Fiscal Year: 2008
    ..RNA interference and gene targeting will be used to reduce expression of the mouse enzyme, and we will engineer HIV with Vif that can bind to and induce degradation of mouse apobec3g. [unreadable] [unreadable]..
  54. Enhancing the immunogenicity of idiotypes for therapy of Non-Hodgkin's lymphoma
    Yvonne Paterson; Fiscal Year: 2006
    ..We will also have tested 3 possible adjuvants to enhance its delivery. This will set the stage for a Phase II proposal focused on preparations for entering clinical trials. [unreadable] [unreadable] [unreadable]..
  55. Modulation of T cell Responses by Ebola Glycoprotein
    Hao Shen; Fiscal Year: 2003
    ....
  56. Etiologic studies on EMND: An animal model for ALS
    Hussni Mohammed; Fiscal Year: 2004
    ..Data obtained from these pilot studies will represent a major breakthrough towards the understanding of the mechanism of the motor neuron disease and lay the foundation for more thorough investigation. ..
  57. Host-pathogen Genetics Using Listeria and Drosophila
    Nancy Freitag; Fiscal Year: 2008
    ..abstract_text> ..
  58. ROLE OF ATP-BINDING CASSETTE TRANSPORTERS IN INNATE INTESTINAL DEFENSE
    Brien Neudeck; Fiscal Year: 2007
    ..Once this is accomplished, we can use this information to develop protective strategies that exploit these preexisting barriers to L. monocytogenes and potentially other pathogens. [unreadable] [unreadable] [unreadable]..
  59. LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLS
    NANCY ELIZABETH FREITAG; Fiscal Year: 2010
    ..The ultimate goal of the proposed work is to elucidate the regulatory pathways that enable bacterial survival within host cells, and the functional identification of additional bacterial factors that support replication within the host. ..