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| plagueSummarySummary: An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form. Top Publications
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Plague: past, present, and futureNils Chr Stenseth
Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway
PLoS Med 5:e3. 2008- Yersinia pestis--etiologic agent of plagueR D Perry
Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
Clin Microbiol Rev 10:35-66. 1997b>Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history... 
Genome sequence of Yersinia pestis, the causative agent of plagueJ Parkhill
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Nature 413:523-7. 2001..Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black ..- Plague outbreaks in prairie dog populations explained by percolation thresholds of alternate host abundanceDaniel J Salkeld
Woods Institute for the Environment and Department of Anthropology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 107:14247-50. 2010Highly lethal pathogens (e.g., hantaviruses, hendra virus, anthrax, or plague) pose unique public-health problems, because they seem to periodically flare into outbreaks before disappearing into long quiescent phases... - Yersinia pestis caf1 variants and the limits of plague vaccine protectionLauriane E Quenee
Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
Infect Immun 76:2025-36. 2008Yersinia pestis, the highly virulent agent of plague, is a biological weapon... - Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosisM Achtman
Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
Proc Natl Acad Sci U S A 96:14043-8. 1999b>Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis. In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic Yersinia species, Y... - Intraspecific diversity of Yersinia pestisAndrey P Anisimov
Department of Infectious Diseases, State Research Center for Applied Microbiology, 142279 Obolensk, Serpukhov District, Moscow Region, Russia
Clin Microbiol Rev 17:434-64. 2004..pestis strains based on genetic and phenotypic variation and show that there is a high level of diversity in these strains not reflected by ones obtained from sylvatic areas and patients in the Americas... - Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plagueClaire A Cornelius
Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
Infect Immun 76:5588-97. 2008..macaques immunized with rLcrV, rV10, or rF1, either alone or in combination, conferred protection against bubonic plague challenge in mice... - The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plagueAvital Tidhar
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
PLoS ONE 4:e7023. 2009Yersinia pestis is the causative agent of plague. Previously we have isolated an attenuated Y. pestis transposon insertion mutant in which the pcm gene was disrupted... - Yersinia pestis biofilm in the flea vector and its role in the transmission of plagueB J Hinnebusch
Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIH, NIAID, Hamilton, MT 59840, USA
Curr Top Microbiol Immunol 322:229-48. 2008..by fleabite is a relatively recent evolutionary adaptation of Yersinia pestis, the bacterial agent of bubonic plague. To produce a transmissible infection, Y. pestis grows as an attached biofilm in the foregut of the flea vector... - Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestisG W Anderson
United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
Infect Immun 64:4580-5. 1996..Immunization protected mice from lethal bubonic and pneumonic plague caused by CO92, a wild-type F1+ strain, or by the isogenic F1- strain C12... - Amino acid residues 196-225 of LcrV represent a plague protective epitopeLauriane E Quenee
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
Vaccine 28:1870-6. 2010..protein that resides at the tip of the type III secretion needles of Yersinia pestis, is the single most important plague protective antigen. Earlier work reported monoclonal antibody MAb 7... - MLVA distribution characteristics of Yersinia pestis in China and the correlation analysisXiaoai Zhang
National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, PR China
BMC Microbiol 9:205. 2009Yersinia pestis, the aetiological agent of plague, has been well defined genotypically on local and worldwide scales... 
Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in MadagascarC Tollenaere
IRD, UMR CBGP INRA IRD Cirad Montpellier SupAgro, Campus International de Baillarguet, CS 30016, 34988 Montferrier sur Lez Cedex, France
Ecohealth 7:242-7. 2010In Madagascar, the black rat, Rattus rattus, is the main reservoir of plague (Yersinia pestis infection), a disease still responsible for hundreds of cases each year in this country...- PlagueE D Williamson
Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wilts SP4 0JQ, UK
Vaccine 27:D56-60. 2009Killed whole cell vaccines for plague were first produced as long ago as the late 1890s and modified versions of these are still used, with evidence that they are efficacious against bubonic plague... - Phylogeography and molecular epidemiology of Yersinia pestis in MadagascarAmy J Vogler
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
PLoS Negl Trop Dis 5:e1319. 2011b>Plague was introduced to Madagascar in 1898 and continues to be a significant human health problem... - Distinct clones of Yersinia pestis caused the black deathStephanie Haensch
Institute for Anthropology, Johannes Gutenberg University, Mainz, Germany
PLoS Pathog 6:e1001134. 2010..It has also been disputed whether plague had the same etiology in northern and southern Europe... - Plague in MongoliaBolormaa Galdan
National Center for Infectious Diseases with Natural Foci, Songinokhairkhan District, Ulaanbaatar, Mongolia
Vector Borne Zoonotic Dis 10:69-75. 2010..7 million people. The geography of Mongolia is varied and has a continental climate. Plague, caused by the bacterium Yersinia pestis, is enzootic in wild rodent populations over large rural areas of .. - The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse backgroundEric H Weening
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
Infect Immun 79:644-52. 2011Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y... - The abundance threshold for plague as a critical percolation phenomenonS Davis
Theoretical Epidemiology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 7, 3584 CL Utrecht, The Netherlands
Nature 454:634-7. 2008..Archived records of plague (infection with Yersinia pestis) in populations of great gerbils (Rhombomys opimus) in Kazakhstan have been used .. - Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestisAlexander G Bobrov
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA
Mol Microbiol 79:533-51. 2011..We report that a mutant incapable of c-di-GMP synthesis is unaffected in virulence in plague mouse models... - Herpesvirus latency confers symbiotic protection from bacterial infectionErik S Barton
Departments of Pathology and Immunology, Washington University Medical School, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nature 447:326-9. 2007..Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host... - Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrVKristin L Debord
Department of Microbiology, University of Chicago, 920 E. 58th Street, Chicago, Illinois 60637, USA
Infect Immun 74:4910-4. 2006..Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine. - Pneumonic plague pathogenesis and immunity in Brown Norway ratsDeborah M Anderson
Department of Veterinary Pathobiology, University of Missouri, 302 Connaway Hall, 1600 E Rollins St, Columbia, MO 65211, USA
Am J Pathol 174:910-21. 2009The Brown Norway rat was recently described as a bubonic plague model that closely mimics human disease... - A horizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillusAnne Derbise
Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Microbiol 63:1145-57. 2007Yersinia pestis, the plague bacillus, has an exceptional pathogenicity but the factors responsible for its extreme virulence are still unknown... - LcrV plague vaccine with altered immunomodulatory propertiesKatie A Overheim
Department of Microbiology, University of Chicago, CLSC607B, 920 East 58th Street, Chicago, IL 60637, USA
Infect Immun 73:5152-9. 2005Yersinia pestis, the causative agent of plague, secretes LcrV (low-calcium-response V or V antigen) during infection... - Genotyping and phylogenetic analysis of Yersinia pestis by MLVA: insights into the worldwide expansion of Central Asia plague fociYanjun Li
Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China
PLoS ONE 4:e6000. 2009.... - Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in TanzaniaWilliam Mwengee
Regional Medical Office, Tanga, Tanzania
Clin Infect Dis 42:614-21. 2006BACKGROUND: Over the past 50 years, antibiotics of choice for treatment of plague, including streptomycin, chloramphenicol, and tetracycline, have mostly become outdated or unavailable... - N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infectionJim Hill
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Vaccine 27:7073-9. 2009..3 and reduced its protective capacity against plague. Since the Mab7... - Natural history of plague: perspectives from more than a century of researchKenneth L Gage
Bacterial Zoonoses Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80523, USA
Annu Rev Entomol 50:505-28. 2005For more than a century, scientists have investigated the natural history of plague, a highly fatal disease caused by infection with the gram-negative bacterium Yersinia pestis... - Kinetics of disease progression and host response in a rat model of bubonic plagueFlorent Sebbane
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Am J Pathol 166:1427-39. 2005b>Plague, caused by the gram-negative bacterium Yersinia pestis, primarily affects rodents but is also an important zoonotic disease of humans... - Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestisJim Hill
Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom
Infect Immun 71:2234-8. 2003..V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection... - Genotyping of Indian Yersinia pestis strains by MLVA and repetitive DNA sequence based PCRsJoseph J Kingston
Division of Microbiology, Defence Food Research Laboratory, Defence Research and Development Organization, Mysore, India
Antonie Van Leeuwenhoek 96:303-12. 2009India experienced two plague outbreaks in Gujarat and Maharastra during 1994 and then in the Shimla district of Himachal Pradesh during 2002... - Yersinia pestis IS1541 transposition provides for escape from plague immunityClaire A Cornelius
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
Infect Immun 77:1807-16. 2009Yersinia pestis is perhaps the most feared infectious agent due to its ability to cause epidemic outbreaks of plague disease in animals and humans with high mortality... - Early-phase transmission of Yersinia pestis by unblocked Xenopsylla cheopis (Siphonaptera: Pulicidae) is as efficient as transmission by blocked fleasRebecca J Eisen
Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Enteric and Vector Borne Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
J Med Entomol 44:678-82. 2007..Xenopsylla cheopis (Rothschild) (Siphonaptera: Pulicidae), was thought to be the most efficient vector of the plague bacterium Yersinia pestis (Yersin)... - Syndromic surveillance and bioterrorism-related epidemicsJames W Buehler
Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Emerg Infect Dis 9:1197-204. 2003 - Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesisR William DePaolo
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Cell Host Microbe 4:350-61. 2008..However, TLR2-/- mice are not protected against subcutaneous plague infection... - Single-dose, virus-vectored vaccine protection against Yersinia pestis challenge: CD4+ cells are required at the time of challenge for optimal protectionAnasuya Chattopadhyay
Department of Pathology, Yale University School of Medicine, 310 Cedar Street LH 315, New Haven, CT 06510, USA
Vaccine 26:6329-37. 2008We have developed an experimental recombinant vesicular stomatitis virus (VSV) vectored plague vaccine expressing a secreted form of Yersinia pestis low calcium response protein V (LcrV) from the first position of the VSV genome... - Yersinia pestis Orientalis in remains of ancient plague patientsMichel Drancourt
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 13:332-3. 2007Yersinia pestis DNA was recently detected in human remains from 2 ancient plague pandemics in France and Germany. We have now sequenced Y pestis glpD gene in such remains, showing a 93-bp deletion specific for biotype Orientalis... - Protective immunity against respiratory tract challenge with Yersinia pestis in mice immunized with an adenovirus-based vaccine vector expressing V antigenMaria J Chiuchiolo
Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
J Infect Dis 194:1249-57. 2006The aerosol form of the bacterium Yersinia pestis causes the pneumonic plague, a rapidly fatal disease. At present, no plague vaccines are available for use in the United States... - Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plagueE D Williamson
Dstl Porton Down, Salisbury, Wilts SP4 0JQ, UK
Vaccine 25:1142-8. 2007.... - Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plagueAyelet Zauberman
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
Vaccine 26:1616-25. 2008b>Plague is a life-threatening disease caused by Yersinia pestis, for which effective-licensed vaccines and reliable predictors of in vivo immunity are lacking. V antigen (LcrV) is a major Y... - Plague vaccines and the molecular basis of immunity against Yersinia pestisLauriane E Quenee
Department of Microbiology, University of Chicago, Chicago, IL, USA
Hum Vaccin 5:817-23. 2009Yersinia pestis is the causative agent of bubonic and pneumonic plague, human diseases with high mortality. Due to the microbe's ability to spread rapidly, plague epidemics present a serious public health threat... - Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacteriumMark Eppinger
Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
J Bacteriol 192:1685-99. 2010To gain insights into the origin and genome evolution of the plague bacterium Yersinia pestis, we have sequenced the deep-rooted strain Angola, a virulent Pestoides isolate... - Rodent and flea abundance fail to predict a plague epizootic in black-tailed prairie dogsRobert Jory Brinkerhoff
Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado 80309 0334, USA
Vector Borne Zoonotic Dis 10:47-52. 2010..for 3 years at a number of prairie dog colony sites in Boulder County, Colorado, before, during, and after a local plague epizootic to see if high rodent or flea abundance was associated with plague-affected colonies when compared to .. - Three Yersinia pestis adhesins facilitate Yop delivery to eukaryotic cells and contribute to plague virulenceSuleyman Felek
Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
Infect Immun 78:4134-50. 2010..Our results indicate that in addition to Ail, Pla and Psa can serve as environmentally specific adhesins to facilitate Yop secretion, a critical virulence function of Y. pestis... - Study on the movement of Rattus rattus and evaluation of the plague dispersion in MadagascarSoanandrasana Rahelinirina
Institut Pasteur de Madagascar, WHO Collaborating Centre for Plague, Antananarivo, Madagascar
Vector Borne Zoonotic Dis 10:77-84. 2010b>Plague affects mainly the rural areas in the central highlands of Madagascar. Rattus rattus is the main rodent host of Yersinia pestis in these localities... - Cynomolgus macaque model for pneumonic plagueRichard Warren
Battelle Biomedical Research Center, 505 King Ave, Columbus, OH 43201, USA
Microb Pathog 50:12-22. 2011A recombinant vaccine (rF1V) is currently being developed for protection against pneumonic plague. An essential component in evaluating efficacy of the rF1V vaccine is the development of a well-understood animal model that shows .. - Assessing human risk of exposure to plague bacteria in northwestern Uganda based on remotely sensed predictorsRebecca J Eisen
Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80522, USA
Am J Trop Med Hyg 82:904-11. 2010b>Plague, a life-threatening flea-borne zoonosis caused by Yersinia pestis, has most commonly been reported from eastern Africa and Madagascar in recent decades... - Attenuated enzootic (pestoides) isolates of Yersinia pestis express active aspartaseScott W Bearden
Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Bacterial Diseases Branch, Fort Collins, CO 80521, USA
Microbiology 155:198-209. 2009It is established that Yersinia pestis, the causative agent of bubonic plague, recently evolved from enteropathogenic Yersinia pseudotuberculosis by undergoing chromosomal degeneration while acquiring two unique plasmids that facilitate .. - Climatic predictors of the intra- and inter-annual distributions of plague cases in New Mexico based on 29 years of animal-based surveillance dataHeidi E Brown
Centers for Disease Control and Prevention CDC, National Center for Zoonotic, Vector Borne and Enteric Diseases, Division of Vector Borne Infectious Diseases, 3150 Rampart Road, Foothills Campus, Fort Collins, CO 80522, USA
Am J Trop Med Hyg 82:95-102. 2010Within the United States, the majority of human plague cases are reported from New Mexico. We describe climatic factors involved in intra- and inter-annual plague dynamics using animal-based surveillance data from that state... - Estimation of vector infectivity rates for plague by means of a standard curve-based competitive polymerase chain reaction method to quantify Yersinia pestis in fleasB J Hinnebusch
Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Am J Trop Med Hyg 58:562-9. 1998..In the case of bubonic plague, infective flea vectors contain large numbers of Yersinia pestis within a bacterial mass that blocks the flea's .. - High throughput, multiplexed pathogen detection authenticates plague waves in medieval Venice, ItalyThi Nguyen Ny Tran
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD 198, IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
PLoS ONE 6:e16735. 2011Historical records suggest that multiple burial sites from the 14th-16th centuries in Venice, Italy, were used during the Black Death and subsequent plague epidemics. - Plague, a reemerging disease in MadagascarS Chanteau
Institut Pasteru, Antananarivo, Madagascar
Emerg Infect Dis 4:101-4. 1998Human cases of plague, which had virtually disappeared in Madagascar after the 1930s, reappeared in 1990 with more than 200 confirmed or presumptive cases reported each year since... - A draft genome of Yersinia pestis from victims of the Black DeathKirsten I Bos
McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada
Nature 478:506-10. 2011..pestis infections... - Bacillus anthracis, Francisella tularensis and Yersinia pestis. The most important bacterial warfare agents - reviewM Pohanka
Center of Advanced Studies and Department of Toxicology, Faculty of Military Health Sciences, University of Defense, 50 001 Hradec Králové, Czech Republic
Folia Microbiol (Praha) 54:263-72. 2009..mentioned one; however, Fracisella tularensis (causing tularemia) and Yersinia pestis (the causative agent of plague) are further bacterial agents enlisted by Centers for Disease Control and Prevention into the category A of .. - Flea diversity and infestation prevalence on rodents in a plague-endemic region of UgandaGerald Amatre
Uganda Virus Research Institute, Entebbe, Uganda
Am J Trop Med Hyg 81:718-24. 2009In Uganda, the West Nile region is the primary epidemiologic focus for plague. The aims of this study were to 1) describe flea-host associations within a plague-endemic region of Uganda, 2) compare flea loads between villages with or .. - The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulationVenkataramanan Soundararajan
Harvard MIT Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Innate Immun 17:548-57. 2011..pestis YopM and perhaps could set the stage for design of new therapeutic opportunities... - Dog-associated risk factors for human plagueL Hannah Gould
Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Bacterial Diseases Branch, Fort Collins, CO, USA
Zoonoses Public Health 55:448-54. 2008b>Plague is a rare but often fatal zoonosis endemic to the western United States. Previous studies have identified contact with pets as a potential risk factor for infection... - Flea-associated zoonotic diseases of cats in the USA: bartonellosis, flea-borne rickettsioses, and plagueKristina M McElroy
Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, 1600 Clifton Road, Atlanta, GA 30333, USA
Trends Parasitol 26:197-204. 2010Cat-scratch disease, flea-borne typhus, and plague are three flea-associated zoonoses of cats of concern in the USA... - TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plagueJr Shiuan Lin
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
Vaccine 29:357-62. 2010..with the Yersinia pestis F1 and LcrV proteins improves survival in mouse and non-human primate models of pneumonic plague. F1- and LcrV-specific antibodies contribute to protection, however, the mechanisms of antibody-mediated defense .. - Immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baitsTonie E Rocke
US Geological Survey, National Wildlife Health Center, Madison, Wisconsin 53711, USA
J Wildl Dis 44:930-7. 2008..are highly susceptible to Yersinia pestis and, along with other wild rodents, are significant reservoirs of plague for other wildlife and humans in the western United States... - Predictors for presence and abundance of small mammals in households of villages endemic for commensal rodent plague in Yunnan Province, ChinaJia Xiang Yin
Yunnan Institute of Endemic Disease Control and Prevention, 5 Wenhua Road, Dali City, Yunnan Province, 671000, PR China
BMC Ecol 8:18. 2008Ninety-one rodent plague epidemics have occurred in Lianghe county, Yunnan Province, China, between 1990 and 2006... - Comparison of immunological responses of plague vaccines F1+rV270 and EV76 in Chinese-origin rhesus macaque, Macaca mulattaY Qiu
Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
Scand J Immunol 72:425-33. 2010..F1+10 μg rV270) has been identified as the optimal formulation in mice, which provided a good protection against plague in mice, guinea pigs and rabbits... - Biofilm formation is not required for early-phase transmission of Yersinia pestisSara M Vetter
Bacterial Diseases Branch, Division of Vector Borne Diseases, National Center for Enteric and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort Collins, CO 80521, USA
Microbiology 156:2216-25. 2010Early-phase transmission (EPT) is a recently described model of plague transmission that explains the rapid spread of disease from flea to mammal host during an epizootic... - Transmission efficiency of two flea species (Oropsylla tuberculata cynomuris and Oropsylla hirsuta) involved in plague epizootics among prairie dogsAryn P Wilder
Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
Ecohealth 5:205-12. 2008b>Plague, caused by Yersinia pestis, is an exotic disease in North America circulating predominantly in wild populations of rodents and their fleas... - Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunizationJ Hill
Microbiology, CBD Porton Down, Salisbury, Wiltshire, United Kingdom
Infect Immun 65:4476-82. 1997..pestis 9B (a fully virulent human pneumonic plague isolate) in a mouse model for plague... - The yersiniae--a model genus to study the rapid evolution of bacterial pathogensBrendan W Wren
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Nat Rev Microbiol 1:55-64. 2003Yersinia pestis, the causative agent of plague, seems to have evolved from a gastrointestinal pathogen, Yersinia pseudotuberculosis, in just 1,500-20,000 years--an 'eye blink' in evolutionary time... - Design and testing for a nontagged F1-V fusion protein as vaccine antigen against bubonic and pneumonic plagueBradford S Powell
United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 1201, USA
Biotechnol Prog 21:1490-510. 2005..pestis challenge strains, modeling prophylaxis against pneumonic and bubonic plague. These findings confirm that the fusion protein architecture provides superior protection over the former licensed .. - Flea, rodent, and plague ecology at Chuchupate Campground, Ventura County, CaliforniaRichard M Davis
Vector-Borne Disease Section, California Department of Health Services, Ventura 93003, USA
J Vector Ecol 27:107-27. 2002..was closed to the public for 18 years (1982 to 2000) because of uncontrolled vector fleas and persistent plague antibody titers in rodents... - Predicting potential risk areas of human plague for the Western Usambara Mountains, Lushoto District, TanzaniaSimon Neerinckx
Evolutionary Ecology Group, Universiteit Antwerpen, Antwerp, Belgium
Am J Trop Med Hyg 82:492-500. 2010A natural focus of plague exists in the Western Usambara Mountains of Tanzania. Despite intense research, questions remain as to why and how plague emerges repeatedly in the same suite of villages... - Defective innate cell response and lymph node infiltration specify Yersinia pestis infectionFrançoise Guinet
Unité des Yersinia, Institut Pasteur, Paris, France
PLoS ONE 3:e1688. 2008Since its recent emergence from the enteropathogen Yersinia pseudotuberculosis, Y. pestis, the plague agent, has acquired an intradermal (id) route of entry and an extreme virulence... - Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestisRoger Van Andel
Lovelace Respiratory Research Institute, Albuquerque, NM, USA
Comp Med 58:68-75. 2008..pestis), the causative agent of plague. A recent symposium concluded that the cynomolgus macaque (Macaca fascicularis) plague model should be .. - Immune defense against pneumonic plagueStephen T Smiley
Trudeau Institute, Saranac Lake, NY 12983, USA
Immunol Rev 225:256-71. 2008..Inhalation of this Gram-negative bacterium causes pneumonic plague, a rapidly progressing and usually fatal disease. Extensively antibiotic-resistant strains of Y... - Geographic distribution and ecological niche of plague in sub-Saharan AfricaSimon B Neerinckx
Department of Biology, Universiteit Antwerpen, Antwerp, Belgium
Int J Health Geogr 7:54. 2008b>Plague is a rapidly progressing, serious illness in humans that is likely to be fatal if not treated. It remains a public health threat, especially in sub-Saharan Africa... - Loss of a biofilm-inhibiting glycosyl hydrolase during the emergence of Yersinia pestisDavid L Erickson
Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
J Bacteriol 190:8163-70. 2008Yersinia pestis, the bacterial agent of plague, forms a biofilm in the foregut of its flea vector to produce a transmissible infection. The closely related Yersinia pseudotuberculosis, from which Y... - A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plagueJessica A Chichester
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Vaccine 27:3471-4. 2009..Therefore there is great interest in developing a safe and effective vaccine. Vaccines against plague containing both the Fraction 1 (F1) and V antigens of Y... - Flea abundance on black-tailed prairie dogs (Cynomys ludovicianus) increases during plague epizooticsDaniel W Tripp
Department of Biology and Shortgrass Steppe Long Term Ecological Project, Colorado State University, Fort Collins, Colorado 80523, USA
Vector Borne Zoonotic Dis 9:313-21. 2009Black-tailed prairie dogs (Cynomys ludovicianus) on the Great Plains of the United States are highly susceptible to plague, caused by the bacterium Yersinia pestis, with mortality on towns during plague epizootics often approaching 100%... - [Prevalence of antibodies against Yersinia pestis in domestic carnivores, in plague foci in the State of Ceará]Antonia Ivoneida Aragão
Secretaria de Saúde do Estado do Ceará, Fortaleza, CE
Rev Soc Bras Med Trop 42:711-5. 2009The prevalence of antibodies against Yersinia pestis in domestic carnivores (dogs and cats), in plague areas in the State of Ceará, was analyzed to establish the importance of monitoring these animals within the routine practice of the .. - Identification of in vivo-induced conserved sequences from Yersinia pestis during experimental plague infection in the rabbitGerard P Andrews
Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming 82070, USA
Vector Borne Zoonotic Dis 10:749-56. 2010..IVI) antigen technology, to detect genes upregulated during infection in a laboratory rabbit model for bubonic plague. After screening over 70,000 Escherichia coli clones of Y... - A live attenuated strain of Yersinia pestis KIM as a vaccine against plagueWei Sun
Center for Infectious Disease and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
Vaccine 29:2986-98. 2011Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y... - Neutrophils are important in early control of lung infection by Yersinia pestisThomas R Laws
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, UK
Microbes Infect 12:331-5. 2010In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils from naïve BALB/c mice were found to reduce numbers of culturable Yersinia pestis strain GB in suspension... - Yersinia pestis with regulated delayed attenuation as a vaccine candidate to induce protective immunity against plagueWei Sun
Center for Infectious Disease and Vaccinology, The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, Arizona 85287, USA
Infect Immun 78:1304-13. 2010..Our results demonstrate that arabinose-dependent regulated crp expression is an effective strategy to attenuate Y. pestis while retaining strong immunogenicity, leading to protection against the pneumonic and bubonic forms of plague. - Range-wide determinants of plague distribution in North AmericaSean P Maher
Department of Ecology and Evolutionary Biology and Biodiversity Institute, University of Kansas, Lawrence, Kansas 66045, USA
Am J Trop Med Hyg 83:736-42. 2010b>Plague, caused by the bacterium Yersinia pestis, is established across western North America, and yet little is known of what determines the broad-scale dimensions of its overall range... - Interannual variability of human plague occurrence in the Western United States explained by tropical and North Pacific Ocean climate variabilityTamara Ben Ari
Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway
Am J Trop Med Hyg 83:624-32. 2010b>Plague is a vector-borne, highly virulent zoonotic disease caused by the bacterium Yersinia pestis. It persists in nature through transmission between its hosts (wild rodents) and vectors (fleas)... - Protection against plague following immunisation with microencapsulated V antigen is reduced by co-encapsulation with IFN-gamma or IL-4, but not IL-6K F Griffin
Dstl Biomedical Sciences, Porton Down, Salisbury, SP4 0JQ, Wiltshire, UK
Vaccine 20:3650-7. 2002We have investigated intranasal delivery of novel vaccines for plague, based on poly-L-lactide (PLLA) microencapsulated recombinant V antigen (rV) of Yersinia pestis... - Lipid A mimetics are potent adjuvants for an intranasal pneumonic plague vaccineChristina L Airhart
Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, 142 Life Science, Moscow, ID 83844 3052, United States
Vaccine 26:5554-61. 2008An effective intranasal (i.n.) vaccine against pneumonic plague was developed. The formulation employed two synthetic lipid A mimetics as adjuvant combined with Yersinia pestis-derived V- and F1-protective antigens... - A parenteral DNA vaccine protects against pneumonic plagueHitoki Yamanaka
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
Vaccine 28:3219-30. 2010..Optimal efficacy against pneumonic plague was obtained in mice i.m.-, not i.n.-immunized with these DNA vaccines... - [Major pulmonary plague outbreak in a mining camp in the Democratic Republic of Congo: brutal awakening of an old scourge]E Bertherat
Department Surveillance et Action, OMS, , Suisse
Med Trop (Mars) 65:511-4. 2005 - Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plagueStephen J Elvin
Defence Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
Microb Pathog 37:177-84. 2004The Caf1 and LcrV sub-unit vaccine for plague has been shown to be highly protective against challenge with virulent Yersinia pestis in a mouse model... - Yersinia pestis: still a plague in the 21st centuryDeborah Josko
School of Health Related Professions, Department of Clinical Laboratory Science, University of Medicine and Dentistry of New Jersey, Newark, NJ 07107, USA
Clin Lab Sci 17:25-9. 2004Yersinia pestis, the causative agent of plague, is an aerobic, non-motile, gram-negative bacillus belonging to the family Enterobacteriacea. It is a zoonotic infection transmitted to humans via the bite of a flea... - Small rodents fleas from the bubonic plague focus located in the Serra dos Orgãos Mountain Range, State of Rio de Janeiro, BrazilR W de Carvalho
Laboratório de Ixodides, Departamento de Entomologia, Instituto Oswaldo Cruz, Fundação do Instituto Oswaldo Cruz, 21045 900 Rio de Janeiro, RJ, Brasil
Mem Inst Oswaldo Cruz 96:603-9. 2001..were collected from 601 small rodents, from November 1995 to October 1997, in areas of natural focus of bubonic plague, including the municipalities of Nova Friburgo, Sumidouro and Teresópolis, State of Rio de Janeiro, Brazil... - Evaluation of the role of the Yersinia pestis plasminogen activator and other plasmid-encoded factors in temperature-dependent blockage of the fleaB J Hinnebusch
Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana, USA
J Infect Dis 178:1406-15. 1998Yersinia pestis, the plague bacillus, has a plasminogen activator (pla) gene on the 9.5-kb plasmid pPla that is hypothesized to play a role in producing the foregut blockage in the flea vector that precedes transmission... - Gentamicin and tetracyclines for the treatment of human plague: review of 75 cases in new Mexico, 1985-1999L Lucy Boulanger
Department of Internal Medicine, Division of Infectious Diseases, University of New Mexico, Albuquerque, NM, USA
Clin Infect Dis 38:663-9. 2004Streptomycin, an antimicrobial with limited availability, is the treatment of choice for plague, a fulminating and potentially epidemic disease that poses a bioterrorism concern... - Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunityJim E Eyles
Biomedical Sciences Department, Dstl, Porton Down, Wiltshire SP4 0JQ, UK
Vaccine 25:7301-6. 2007..and vaccine by different routes was evaluated as a means of providing both rapid and long-term protection against plague. BALB/c mice were treated intraperitoneally with monoclonal antibodies, with specificities for Yersinia pestis .. - A comparison of immunogenicity and protective immunity against experimental plague by intranasal and/or combined with oral immunization of mice with attenuated Salmonella serovar Typhimurium expressing secreted Yersinia pestis F1 and V antigenWen Tssann Liu
Institute of Preventive Medicine, National Defence Medical Center, Taipei, Taiwan
FEMS Immunol Med Microbiol 51:58-69. 2007..n. x 2 immunization with X85V provided levels of protection against a subsequent lethal challenge with Y. pestis, of, respectively, 60% and 20%, whereas 80% protection was provided following the same immunization but with X85MF1... - Co-immunisation with a plasmid DNA cocktail primes mice against anthrax and plagueE D Williamson
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 OJQ, UK
Vaccine 20:2933-41. 2002..pestis compared with priming only with plasmid DNA encoding the V antigen and boosting with rV. This enhancement may be due to the effect of CpG motifs known to be present in the plasmid DNA construct encoding PA... - Protection against lethal subcutaneous challenge of virulent Y. pestis strain 141 using an F1-V subunit vaccineDong Wang
Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China
Sci China C Life Sci 50:600-4. 2007..These findings suggested that the plague F1-V subunit vaccine is promising for the next plague vaccine. - [The plague from antiquity to today and its final incursions into southern Italy]G Rizzo
Dip. di Medicina Interna e Medicina Publica, Sez. Igiene,
Ann Ig 14:141-52. 2002 - Epidemiology. Plague annals help bring microbe lab in from the coldRichard Stone
Science 304:673. 2004 - Predictive thresholds for plague in KazakhstanStephen Davis
Danish Pest Infestation Laboratory, Skovbrynet 14, DK-2800 Kongens Lyngby, Denmark
Science 304:736-8. 2004..Yersinia pestis circulates in natural populations of gerbils, which are the source of human cases of bubonic plague. Our analysis of field data collected between 1955 and 1996 shows that plague invades, fades out, and reinvades in ..
Research Grants
- Pacific-Southwest Ctr for Biodefense & Emerg Infect Dis*Alan Barbour; Fiscal Year: 2007..of the programs are anthrax vaccines, arboviruses, arenaviruses, botulinum toxin, Burkholderia, hantaviruses, plague, and tularemia...
- Lung Injury and Shock Pathogenesis in Y. pestis SepsisANDREW LECHNER; Fiscal Year: 2006Yersinia pestis is the causative agent of plague, a pandemic clinically divided into bubonic, septicemic, and pneumonic diseases...
- Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenzaKelly Henrickson; Fiscal Year: 2007..threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that ..
- Combinatorial vaccines against anthrax and plagueJohn Clements; Fiscal Year: 2006..immunization of civilian and military populations against potential bioterrorism agents, including anthrax and plague, Vaccines combining protective antigens from different microorganisms with potential for use against civilian or ..
- Inhaled Aminoglycoside Formulafor Plague and TularemiaJames Talton; Fiscal Year: 2005..for post-exposure treatment of aerosol exposure of the Category A bioterrorism agents pneumonic Yersina pestis (plague) and Francisella tularensis (tularemia)...
- Pheresis Treatment of Bioterrorism-Induced SepsisStephen Ash; Fiscal Year: 2005Victims of bacterial bioterrorism agents such as anthrax, plague, and tularemia die very often because of septicemia and subsequent multiple organ dysfunction syndrome (MODS)...
- Molecular mechanism of immune evasion by Yersinia pestisTomas Mustelin; Fiscal Year: 2003Yersina pestis, the ethiologic agent of plague or Black Death, has in historical times caused devastating pandemics unrivaled by any other infectious disease...
- The role of LPS-TLR4 signaling in live vaccine-induced protective responsesEgil Lien; Fiscal Year: 2010..The gram-negative bacterium Yersinia pestis is the causative agent of plague. Currently there is no available licensed plague vaccine, and exploratory vaccines have variable ability to ..
- Neurophysiological and Neuropharmacological Studies of a Parasitic NematodeRalph Davis; Fiscal Year: 2006Parasitic nematodes plague the world as major contributors to disease, and anti-parasitic drugs (anthelmintics) are the primary control measure...
- Cambodia: Between the Khmers Rouges and the Red Plague?Patrick Heuveline; Fiscal Year: 2003..The existence of this long-term observatory will complement and enhance future substantive research in this population. ..
- Mechanism of anti-phagocytosis by Yersinia pestisKristiina Vuori; Fiscal Year: 2005Yersinia pestis, the causative agent of plague, is one of the most pathogenic bacteria known to mankind. Due to its high pathogenicity, Yersinia has been recognized as a potential weapon for bioterrorism...
- The Role of LPS and Toll-like Receptors in PlagueEgil Lien; Fiscal Year: 2007The Gram-negative bacteria Yersinia pestis is the causative agent of plague, and is classified as an NIAID category A priority biodefense agent. Y...
- A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARsCONSTANCE WILSON; Fiscal Year: 2007Yersinia pestis (Y. pestis), the causative agent of plague, is a Gram-negative bacillus that is classified as a Category A pathogen by the Centers for Disease Control and a logical choice as a biological weapon...
- RovA regulon of Yersinia pestisVIRGINIA MILLER; Fiscal Year: 2003Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality...
- HOST RANGE DIVERSITY OF BACTERIOPHAGE FOR Y. PESTISDavid Martin; Fiscal Year: 2006Yersinia pestis, the bacterium responsible for plague, is a Category A pathogen, a significant biowarfare agent. If weaponized, it can easily gain direct access to the respiratory system to cause rapid death by pneumonic plague...