plague

Summary

Summary: An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.

Top Publications

  1. pmc Plague: past, present, and future
    Nils Chr Stenseth
    Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway
    PLoS Med 5:e3. 2008
  2. pmc Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
    Giovanna Morelli
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Berlin, Germany
    Nat Genet 42:1140-3. 2010
  3. pmc A draft genome of Yersinia pestis from victims of the Black Death
    Kirsten I Bos
    McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada
    Nature 478:506-10. 2011
  4. ncbi Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
    Sara W Montminy
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:1066-73. 2006
  5. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
  6. pmc Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 5:e1319. 2011
  7. pmc Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity
    Wyndham W Lathem
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:17786-91. 2005
  8. pmc Plague outbreaks in prairie dog populations explained by percolation thresholds of alternate host abundance
    Daniel J Salkeld
    Woods Institute for the Environment and Department of Anthropology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14247-50. 2010
  9. doi Cynomolgus macaque model for pneumonic plague
    Richard Warren
    Battelle Biomedical Research Center, 505 King Ave, Columbus, OH 43201, USA
    Microb Pathog 50:12-22. 2011
  10. ncbi Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host
    Haihong Liu
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
    J Basic Microbiol 49:92-9. 2009

Detail Information

Publications316 found, 100 shown here

  1. pmc Plague: past, present, and future
    Nils Chr Stenseth
    Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway
    PLoS Med 5:e3. 2008
  2. pmc Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
    Giovanna Morelli
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Berlin, Germany
    Nat Genet 42:1140-3. 2010
    b>Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y...
  3. pmc A draft genome of Yersinia pestis from victims of the Black Death
    Kirsten I Bos
    McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada
    Nature 478:506-10. 2011
    ..pestis infections...
  4. ncbi Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
    Sara W Montminy
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:1066-73. 2006
    At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes lipopolysaccharide (LPS)-lipid A with poor Toll-like receptor 4 (TLR4)-stimulating activity...
  5. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
    b>Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history...
  6. pmc Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 5:e1319. 2011
    b>Plague was introduced to Madagascar in 1898 and continues to be a significant human health problem...
  7. pmc Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity
    Wyndham W Lathem
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:17786-91. 2005
    Although pneumonic plague is the deadliest manifestation of disease caused by the bacterium Yersinia pestis, there is surprisingly little information on the cellular and molecular mechanisms responsible for Y...
  8. pmc Plague outbreaks in prairie dog populations explained by percolation thresholds of alternate host abundance
    Daniel J Salkeld
    Woods Institute for the Environment and Department of Anthropology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14247-50. 2010
    Highly lethal pathogens (e.g., hantaviruses, hendra virus, anthrax, or plague) pose unique public-health problems, because they seem to periodically flare into outbreaks before disappearing into long quiescent phases...
  9. doi Cynomolgus macaque model for pneumonic plague
    Richard Warren
    Battelle Biomedical Research Center, 505 King Ave, Columbus, OH 43201, USA
    Microb Pathog 50:12-22. 2011
    A recombinant vaccine (rF1V) is currently being developed for protection against pneumonic plague. An essential component in evaluating efficacy of the rF1V vaccine is the development of a well-understood animal model that shows ..
  10. ncbi Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host
    Haihong Liu
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
    J Basic Microbiol 49:92-9. 2009
    Despite the importance of pneumonic plague caused by Yersinia pestis, a few is known about the interaction between Y. pestis and its host at the molecular level during the pneumonic plague development...
  11. pmc Climate variability and change in the United States: potential impacts on vector- and rodent-borne diseases
    D J Gubler
    Division of Vectorborne Infectious Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Environ Health Perspect 109:223-33. 2001
    Diseases such as plague, typhus, malaria, yellow fever, and dengue fever, transmitted between humans by blood-feeding arthropods, were once common in the United States...
  12. pmc Intraspecific diversity of Yersinia pestis
    Andrey P Anisimov
    Department of Infectious Diseases, State Research Center for Applied Microbiology, 142279 Obolensk, Serpukhov District, Moscow Region, Russia
    Clin Microbiol Rev 17:434-64. 2004
    ..pestis strains based on genetic and phenotypic variation and show that there is a high level of diversity in these strains not reflected by ones obtained from sylvatic areas and patients in the Americas...
  13. pmc Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague
    Florent Sebbane
    Laboratory of Zoonotic Pathogens and Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:5526-30. 2006
    Yersinia pestis is transmitted by fleas and causes bubonic plague, characterized by severe local lymphadenitis that progresses rapidly to systemic infection and life-threatening septicemia...
  14. ncbi Poor vector competence of fleas and the evolution of hypervirulence in Yersinia pestis
    Ellen A Lorange
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 191:1907-12. 2005
    ..indicated that arthropodborne transmission is an evolutionarily recent adaptation in Yersinia pestis, the agent of plague. We show that the infectivity of Y...
  15. pmc RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague
    Jason S Cathelyn
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:13514-9. 2006
    ..p. route, indicating a more important role for RovA in bubonic plague than pneumonic plague or systemic infection. Microarray analysis was used to define the RovA regulon...
  16. pmc Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation
    Paul A Price
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:3083-8. 2012
    Disease progression of primary pneumonic plague is biphasic, consisting of a preinflammatory and a proinflammatory phase...
  17. pmc Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague
    Zhan Ye
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Infect Immun 79:674-87. 2011
    We are using a systemic plague model to identify the cells and pathways that are undermined by the virulence protein YopM of the plague bacterium Yersinia pestis...
  18. ncbi From the recent lessons of the Malagasy foci towards a global understanding of the factors involved in plague reemergence
    Jean Marc Duplantier
    Programme RAMSE, IRD Madagascar, Madagascar
    Vet Res 36:437-53. 2005
    Re-emergence of human cases of plague after decades of silence does not necessarily mean that plague foci are re-emerging. Most often, Yersinia pestis bacteria have been maintained and circulating at low levels in the rodent populations...
  19. pmc Imaging of bubonic plague dynamics by in vivo tracking of bioluminescent Yersinia pestis
    Toan Nham
    Yersinia Research Unit, Institut Pasteur, Paris, France
    PLoS ONE 7:e34714. 2012
    ..In this work we used in vivo bioluminescence imaging (BLI) to follow Y. pestis dissemination during bubonic plague. We first demonstrated that Y...
  20. pmc Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague
    Florent Sebbane
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:11766-71. 2006
    Yersinia pestis causes bubonic plague, characterized by an enlarged, painful lymph node, termed a bubo, that develops after bacterial dissemination from a fleabite site...
  21. pmc Transcriptomic and innate immune responses to Yersinia pestis in the lymph node during bubonic plague
    Jason E Comer
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 78:5086-98. 2010
    ..inflammatory response is a prominent feature of infection with Yersinia pestis, the agent of bubonic and pneumonic plague. Using a rat model of bubonic plague, we examined lymph node histopathology, transcriptome, and extracellular ..
  22. pmc High throughput, multiplexed pathogen detection authenticates plague waves in medieval Venice, Italy
    Thi Nguyen Ny Tran
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD 198, IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    PLoS ONE 6:e16735. 2011
    Historical records suggest that multiple burial sites from the 14th-16th centuries in Venice, Italy, were used during the Black Death and subsequent plague epidemics.
  23. pmc Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague
    Claire A Cornelius
    Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
    Infect Immun 76:5588-97. 2008
    ..macaques immunized with rLcrV, rV10, or rF1, either alone or in combination, conferred protection against bubonic plague challenge in mice...
  24. pmc Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium
    Mark Eppinger
    Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Bacteriol 192:1685-99. 2010
    To gain insights into the origin and genome evolution of the plague bacterium Yersinia pestis, we have sequenced the deep-rooted strain Angola, a virulent Pestoides isolate...
  25. pmc Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis
    R William DePaolo
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 4:350-61. 2008
    ..However, TLR2-/- mice are not protected against subcutaneous plague infection...
  26. pmc Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
    b>Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis. In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic Yersinia species, Y...
  27. pmc Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis
    G W Anderson
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Infect Immun 64:4580-5. 1996
    ..Immunization protected mice from lethal bubonic and pneumonic plague caused by CO92, a wild-type F1+ strain, or by the isogenic F1- strain C12...
  28. pmc Assessing human risk of exposure to plague bacteria in northwestern Uganda based on remotely sensed predictors
    Rebecca J Eisen
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80522, USA
    Am J Trop Med Hyg 82:904-11. 2010
    b>Plague, a life-threatening flea-borne zoonosis caused by Yersinia pestis, has most commonly been reported from eastern Africa and Madagascar in recent decades...
  29. doi Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar
    C Tollenaere
    IRD, UMR CBGP INRA IRD Cirad Montpellier SupAgro, Campus International de Baillarguet, CS 30016, 34988 Montferrier sur Lez Cedex, France
    Ecohealth 7:242-7. 2010
    In Madagascar, the black rat, Rattus rattus, is the main reservoir of plague (Yersinia pestis infection), a disease still responsible for hundreds of cases each year in this country...
  30. pmc Kinetics of disease progression and host response in a rat model of bubonic plague
    Florent Sebbane
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Am J Pathol 166:1427-39. 2005
    b>Plague, caused by the gram-negative bacterium Yersinia pestis, primarily affects rodents but is also an important zoonotic disease of humans...
  31. pmc Immune defense against pneumonic plague
    Stephen T Smiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 225:256-71. 2008
    ..Inhalation of this Gram-negative bacterium causes pneumonic plague, a rapidly progressing and usually fatal disease. Extensively antibiotic-resistant strains of Y...
  32. pmc Humans and evolutionary and ecological forces shaped the phylogeography of recently emerged diseases
    PAUL S KEIM
    The Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    Nat Rev Microbiol 7:813-21. 2009
    ..Anthrax, plague and tularaemia are three zoonotic diseases that have been intensely studied through genome characterization of the ..
  33. pmc TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague
    Jr Shiuan Lin
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Vaccine 29:357-62. 2010
    ..with the Yersinia pestis F1 and LcrV proteins improves survival in mouse and non-human primate models of pneumonic plague. F1- and LcrV-specific antibodies contribute to protection, however, the mechanisms of antibody-mediated defense ..
  34. pmc Role of the Yersinia pestis yersiniabactin iron acquisition system in the incidence of flea-borne plague
    Florent Sebbane
    Equipe Peste et Yersinia pestis, Centre d Infection et d Immunité de Lille, Institut Pasteur de Lille, Lille, France
    PLoS ONE 5:e14379. 2010
    b>Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis. Y...
  35. doi Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice
    Christian E Demeure
    Yersinia Research Unit, Institut Pasteur, Paris, France
    J Infect Dis 205:134-43. 2012
    ..mice are usually highly susceptible to Yersinia pestis, we recently identified a mouse strain (SEG) that exhibited an exceptional capacity to resist bubonic plague and used it to identify immune mechanisms associated with resistance.
  36. pmc Novel genetic tools for diaminopimelic acid selection in virulence studies of Yersinia pestis
    David M Bland
    Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America
    PLoS ONE 6:e17352. 2011
    ..The dapAX mutation rendered Y. pestis avirulent in mouse models of bubonic and septicemic plague which could be complemented when dapAX was inserted in single or multi-copy, restoring development of disease that ..
  37. pmc Plague and climate: scales matter
    Tamara Ben-Ari
    Centre for Ecological and Evolutionary Synthesis CEES, University of Oslo, Oslo, Norway
    PLoS Pathog 7:e1002160. 2011
    b>Plague is enzootic in wildlife populations of small mammals in central and eastern Asia, Africa, South and North America, and has been recognized recently as a reemerging threat to humans...
  38. pmc Genotyping, Orientalis-like Yersinia pestis, and plague pandemics
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 10:1585-92. 2004
    Three pandemics have been attributed to plague in the last 1,500 years. Yersinia pestis caused the third, and its DNA was found in human remains from the second. The Antiqua biovar of Y...
  39. pmc A live attenuated strain of Yersinia pestis KIM as a vaccine against plague
    Wei Sun
    Center for Infectious Disease and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Vaccine 29:2986-98. 2011
    Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y...
  40. pmc IL-17 contributes to cell-mediated defense against pulmonary Yersinia pestis infection
    Jr Shiuan Lin
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 186:1675-84. 2011
    Pneumonic plague is one of the world's most deadly infectious diseases. The causative bacterium, Yersinia pestis, has the potential to be exploited as a biological weapon, and no vaccine is available...
  41. pmc Role of the Yersinia pestis Ail protein in preventing a protective polymorphonuclear leukocyte response during bubonic plague
    B Joseph Hinnebusch
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 79:4984-9. 2011
    The ability of Yersinia pestis to forestall the mammalian innate immune response is a fundamental aspect of plague pathogenesis. In this study, we examined the effect of Ail, a 17-kDa outer membrane protein that protects Y...
  42. ncbi Genome sequence of Yersinia pestis, the causative agent of plague
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 413:523-7. 2001
    ..Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black ..
  43. pmc Current trends in plague research: from genomics to virulence
    Xiao Zhe Huang
    Division of Communicable Immunology, Department of Bacterial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Clin Med Res 4:189-99. 2006
    Yersinia pestis is the causative agent of plague, which diverged from Yersinia pseudotuberculosis within the past 20,000 years...
  44. pmc The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background
    Eric H Weening
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    Infect Immun 79:644-52. 2011
    Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y...
  45. pmc Distinct clones of Yersinia pestis caused the black death
    Stephanie Haensch
    Institute for Anthropology, Johannes Gutenberg University, Mainz, Germany
    PLoS Pathog 6:e1001134. 2010
    ..It has also been disputed whether plague had the same etiology in northern and southern Europe...
  46. pmc Amino acid residues 196-225 of LcrV represent a plague protective epitope
    Lauriane E Quenee
    Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Vaccine 28:1870-6. 2010
    ..protein that resides at the tip of the type III secretion needles of Yersinia pestis, is the single most important plague protective antigen. Earlier work reported monoclonal antibody MAb 7...
  47. pmc MLVA distribution characteristics of Yersinia pestis in China and the correlation analysis
    Xiaoai Zhang
    National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, PR China
    BMC Microbiol 9:205. 2009
    Yersinia pestis, the aetiological agent of plague, has been well defined genotypically on local and worldwide scales...
  48. doi Plague in Mongolia
    Bolormaa Galdan
    National Center for Infectious Diseases with Natural Foci, Songinokhairkhan District, Ulaanbaatar, Mongolia
    Vector Borne Zoonotic Dis 10:69-75. 2010
    ..7 million people. The geography of Mongolia is varied and has a continental climate. Plague, caused by the bacterium Yersinia pestis, is enzootic in wild rodent populations over large rural areas of ..
  49. ncbi The abundance threshold for plague as a critical percolation phenomenon
    S Davis
    Theoretical Epidemiology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 7, 3584 CL Utrecht, The Netherlands
    Nature 454:634-7. 2008
    ..Archived records of plague (infection with Yersinia pestis) in populations of great gerbils (Rhombomys opimus) in Kazakhstan have been used ..
  50. ncbi Plague
    E D Williamson
    Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wilts SP4 0JQ, UK
    Vaccine 27:D56-60. 2009
    Killed whole cell vaccines for plague were first produced as long ago as the late 1890s and modified versions of these are still used, with evidence that they are efficacious against bubonic plague...
  51. pmc Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA
    Mol Microbiol 79:533-51. 2011
    ..We report that a mutant incapable of c-di-GMP synthesis is unaffected in virulence in plague mouse models...
  52. pmc The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague
    Avital Tidhar
    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
    PLoS ONE 4:e7023. 2009
    Yersinia pestis is the causative agent of plague. Previously we have isolated an attenuated Y. pestis transposon insertion mutant in which the pcm gene was disrupted...
  53. ncbi A 12-case outbreak of pharyngeal plague following the consumption of camel meat, in north-eastern Jordan
    A Arbaji
    Ministry of Health, P O Box 86, Amman, and Department of Biological Sciences, Jordan University of Science and Technology, Irbid, Jordan
    Ann Trop Med Parasitol 99:789-93. 2005
    Between late January and early February 1997, an outbreak of plague, associated with cervical lymphadenopathy and fever, occurred in the Jordanian village of Azraq ad-Druze, which lies about 50 km west of the border with Saudi Arabia...
  54. pmc Yersinia pestis caf1 variants and the limits of plague vaccine protection
    Lauriane E Quenee
    Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
    Infect Immun 76:2025-36. 2008
    Yersinia pestis, the highly virulent agent of plague, is a biological weapon...
  55. pmc Pathogenesis of Yersinia pestis infection in BALB/c mice: effects on host macrophages and neutrophils
    Roman A Lukaszewski
    Department of Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, United Kingdom
    Infect Immun 73:7142-50. 2005
    The pathogenesis of infection with Yersinia pestis, the causative agent of plague, was examined following subcutaneous infection of BALB/c mice with a fully virulent strain expressing green fluorescent protein...
  56. doi Neutrophils are important in early control of lung infection by Yersinia pestis
    Thomas R Laws
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, UK
    Microbes Infect 12:331-5. 2010
    In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils from naïve BALB/c mice were found to reduce numbers of culturable Yersinia pestis strain GB in suspension...
  57. pmc Yersinia pestis Orientalis in remains of ancient plague patients
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:332-3. 2007
    Yersinia pestis DNA was recently detected in human remains from 2 ancient plague pandemics in France and Germany. We have now sequenced Y pestis glpD gene in such remains, showing a 93-bp deletion specific for biotype Orientalis...
  58. pmc Yersinia pestis biofilm in the flea vector and its role in the transmission of plague
    B J Hinnebusch
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIH, NIAID, Hamilton, MT 59840, USA
    Curr Top Microbiol Immunol 322:229-48. 2008
    ..by fleabite is a relatively recent evolutionary adaptation of Yersinia pestis, the bacterial agent of bubonic plague. To produce a transmissible infection, Y. pestis grows as an attached biofilm in the foregut of the flea vector...
  59. pmc Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague
    Ayelet Zauberman
    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
    PLoS ONE 4:e5938. 2009
    ..Previous observations have indicated that Yersinia pestis, the causative agent of plague disease, exhibits restricted capacity to induce cell death in macrophages due to ineffective translocation of the ..
  60. pmc The Yersinia pestis caf1M1A1 fimbrial capsule operon promotes transmission by flea bite in a mouse model of bubonic plague
    Florent Sebbane
    Institut National de la Sante et de la Recherche Medicale, U801, Institut Pasteur de Lille, Lille, France
    Infect Immun 77:1222-9. 2009
    b>Plague is a zoonosis transmitted by fleas and caused by the gram-negative bacterium Yersinia pestis. During infection, the plasmidic caf1M1A1 operon that encodes the Y...
  61. pmc Defective innate cell response and lymph node infiltration specify Yersinia pestis infection
    Françoise Guinet
    Unité des Yersinia, Institut Pasteur, Paris, France
    PLoS ONE 3:e1688. 2008
    Since its recent emergence from the enteropathogen Yersinia pseudotuberculosis, Y. pestis, the plague agent, has acquired an intradermal (id) route of entry and an extreme virulence...
  62. ncbi Herpesvirus latency confers symbiotic protection from bacterial infection
    Erik S Barton
    Departments of Pathology and Immunology, Washington University Medical School, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 447:326-9. 2007
    ..Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host...
  63. pmc Pneumonic plague pathogenesis and immunity in Brown Norway rats
    Deborah M Anderson
    Department of Veterinary Pathobiology, University of Missouri, 302 Connaway Hall, 1600 E Rollins St, Columbia, MO 65211, USA
    Am J Pathol 174:910-21. 2009
    The Brown Norway rat was recently described as a bubonic plague model that closely mimics human disease...
  64. pmc Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV
    Kristin L Debord
    Department of Microbiology, University of Chicago, 920 E 58th Street, Chicago, Illinois 60637, USA
    Infect Immun 74:4910-4. 2006
    ..Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.
  65. ncbi Transcriptome analysis of Yersinia pestis in human plasma: an approach for discovering bacterial genes involved in septicaemic plague
    Sylvie Chauvaux
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Microbiology 153:3112-24. 2007
    Yersinia pestis is the aetiologic agent of plague. Without appropriate treatment, the pathogen rapidly causes septicaemia, the terminal and fatal phase of the disease...
  66. pmc Genotyping and phylogenetic analysis of Yersinia pestis by MLVA: insights into the worldwide expansion of Central Asia plague foci
    Yanjun Li
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 4:e6000. 2009
    ....
  67. pmc yadBC of Yersinia pestis, a new virulence determinant for bubonic plague
    Stanislav Forman
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Infect Immun 76:578-87. 2008
    ..pestis adherence, invasion, and virulence. We found that loss of yadBC caused a modest loss of invasiveness for epithelioid cells and a large decrease in virulence for bubonic plague but not for pneumonic plague in mice.
  68. pmc Syndromic surveillance and bioterrorism-related epidemics
    James W Buehler
    Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Emerg Infect Dis 9:1197-204. 2003
  69. doi Characterization of the rat pneumonic plague model: infection kinetics following aerosolization of Yersinia pestis CO92
    Stacy L Agar
    Departments of Microbiology and Immunology, UTMB, 301 University Boulevard, MRB 3 142H, Galveston, TX 77555 1070, USA
    Microbes Infect 11:205-14. 2009
    Yersinia pestis, the causative agent of human bubonic and pneumonic plague, is spread during natural infection by the fleas of rodents...
  70. ncbi Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague
    Xinghong Yang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 178:1059-67. 2007
    ..Salmonella-(F1+V)Ags elicited elevated Ab titers similar to their monotypic derivatives. For bubonic plague, mice dosed with Salmonella-(F1+V)Ags and Salmonella-F1-Ag showed similar efficacy (>83% survival) against ..
  71. pmc LcrV plague vaccine with altered immunomodulatory properties
    Katie A Overheim
    Department of Microbiology, University of Chicago, CLSC607B, 920 East 58th Street, Chicago, IL 60637, USA
    Infect Immun 73:5152-9. 2005
    Yersinia pestis, the causative agent of plague, secretes LcrV (low-calcium-response V or V antigen) during infection...
  72. ncbi A horizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillus
    Anne Derbise
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 63:1145-57. 2007
    Yersinia pestis, the plague bacillus, has an exceptional pathogenicity but the factors responsible for its extreme virulence are still unknown...
  73. ncbi Fleas and flea-borne diseases
    Idir Bitam
    Unité de Recherche en Maladies Infectieuses Tropicales Emergentes, CNRS IRD UMR 6236, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, Marseille Cedex 5, France
    Int J Infect Dis 14:e667-76. 2010
    ..Such an overall review is necessary to understand the importance of this group of infections and the resources that must be allocated to their control by public health authorities to ensure their timely diagnosis and treatment...
  74. pmc Nonlinear effect of climate on plague during the third pandemic in China
    Lei Xu
    State Key Laboratory of Integrated Management on Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 108:10214-9. 2011
    Over the years, plague has caused a large number of deaths worldwide and subsequently changed history, not the least during the period of the Black Death. Of the three plague pandemics, the third is believed to have originated in China...
  75. doi Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague
    Ayelet Zauberman
    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
    Vaccine 26:1616-25. 2008
    b>Plague is a life-threatening disease caused by Yersinia pestis, for which effective-licensed vaccines and reliable predictors of in vivo immunity are lacking. V antigen (LcrV) is a major Y...
  76. pmc Single-dose, virus-vectored vaccine protection against Yersinia pestis challenge: CD4+ cells are required at the time of challenge for optimal protection
    Anasuya Chattopadhyay
    Department of Pathology, Yale University School of Medicine, 310 Cedar Street LH 315, New Haven, CT 06510, USA
    Vaccine 26:6329-37. 2008
    We have developed an experimental recombinant vesicular stomatitis virus (VSV) vectored plague vaccine expressing a secreted form of Yersinia pestis low calcium response protein V (LcrV) from the first position of the VSV genome...
  77. ncbi Protective immunity against respiratory tract challenge with Yersinia pestis in mice immunized with an adenovirus-based vaccine vector expressing V antigen
    Maria J Chiuchiolo
    Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Infect Dis 194:1249-57. 2006
    The aerosol form of the bacterium Yersinia pestis causes the pneumonic plague, a rapidly fatal disease. At present, no plague vaccines are available for use in the United States...
  78. pmc Plague, a reemerging disease in Madagascar
    S Chanteau
    Institut Pasteru, Antananarivo, Madagascar
    Emerg Infect Dis 4:101-4. 1998
    Human cases of plague, which had virtually disappeared in Madagascar after the 1930s, reappeared in 1990 with more than 200 confirmed or presumptive cases reported each year since...
  79. doi Study on the movement of Rattus rattus and evaluation of the plague dispersion in Madagascar
    Soanandrasana Rahelinirina
    Institut Pasteur de Madagascar, WHO Collaborating Centre for Plague, Antananarivo, Madagascar
    Vector Borne Zoonotic Dis 10:77-84. 2010
    b>Plague affects mainly the rural areas in the central highlands of Madagascar. Rattus rattus is the main rodent host of Yersinia pestis in these localities...
  80. ncbi Estimation of vector infectivity rates for plague by means of a standard curve-based competitive polymerase chain reaction method to quantify Yersinia pestis in fleas
    B J Hinnebusch
    Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Am J Trop Med Hyg 58:562-9. 1998
    ..In the case of bubonic plague, infective flea vectors contain large numbers of Yersinia pestis within a bacterial mass that blocks the flea's ..
  81. pmc Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis
    Jim Hill
    Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom
    Infect Immun 71:2234-8. 2003
    ..V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection...
  82. ncbi Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania
    William Mwengee
    Regional Medical Office, Tanga, Tanzania
    Clin Infect Dis 42:614-21. 2006
    Over the past 50 years, antibiotics of choice for treatment of plague, including streptomycin, chloramphenicol, and tetracycline, have mostly become outdated or unavailable...
  83. ncbi Early-phase transmission of Yersinia pestis by unblocked Xenopsylla cheopis (Siphonaptera: Pulicidae) is as efficient as transmission by blocked fleas
    Rebecca J Eisen
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Enteric and Vector Borne Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
    J Med Entomol 44:678-82. 2007
    ..Xenopsylla cheopis (Rothschild) (Siphonaptera: Pulicidae), was thought to be the most efficient vector of the plague bacterium Yersinia pestis (Yersin)...
  84. pmc Three Yersinia pestis adhesins facilitate Yop delivery to eukaryotic cells and contribute to plague virulence
    Suleyman Felek
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Infect Immun 78:4134-50. 2010
    ..Our results indicate that in addition to Ail, Pla and Psa can serve as environmentally specific adhesins to facilitate Yop secretion, a critical virulence function of Y. pestis...
  85. pmc Climatic predictors of the intra- and inter-annual distributions of plague cases in New Mexico based on 29 years of animal-based surveillance data
    Heidi E Brown
    Centers for Disease Control and Prevention CDC, National Center for Zoonotic, Vector Borne and Enteric Diseases, Division of Vector Borne Infectious Diseases, 3150 Rampart Road, Foothills Campus, Fort Collins, CO 80522, USA
    Am J Trop Med Hyg 82:95-102. 2010
    Within the United States, the majority of human plague cases are reported from New Mexico. We describe climatic factors involved in intra- and inter-annual plague dynamics using animal-based surveillance data from that state...
  86. doi The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulation
    Venkataramanan Soundararajan
    Harvard MIT Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Innate Immun 17:548-57. 2011
    ..pestis YopM and perhaps could set the stage for design of new therapeutic opportunities...
  87. ncbi Natural history of plague: perspectives from more than a century of research
    Kenneth L Gage
    Bacterial Zoonoses Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80523, USA
    Annu Rev Entomol 50:505-28. 2005
    For more than a century, scientists have investigated the natural history of plague, a highly fatal disease caused by infection with the gram-negative bacterium Yersinia pestis...
  88. pmc Yersinia pestis IS1541 transposition provides for escape from plague immunity
    Claire A Cornelius
    Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Infect Immun 77:1807-16. 2009
    Yersinia pestis is perhaps the most feared infectious agent due to its ability to cause epidemic outbreaks of plague disease in animals and humans with high mortality...
  89. doi Attenuated enzootic (pestoides) isolates of Yersinia pestis express active aspartase
    Scott W Bearden
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Bacterial Diseases Branch, Fort Collins, CO 80521, USA
    Microbiology 155:198-209. 2009
    It is established that Yersinia pestis, the causative agent of bubonic plague, recently evolved from enteropathogenic Yersinia pseudotuberculosis by undergoing chromosomal degeneration while acquiring two unique plasmids that facilitate ..
  90. doi Genotyping of Indian Yersinia pestis strains by MLVA and repetitive DNA sequence based PCRs
    Joseph J Kingston
    Division of Microbiology, Defence Food Research Laboratory, Defence Research and Development Organization, Mysore, India
    Antonie Van Leeuwenhoek 96:303-12. 2009
    India experienced two plague outbreaks in Gujarat and Maharastra during 1994 and then in the Shimla district of Himachal Pradesh during 2002...
  91. ncbi Bacillus anthracis, Francisella tularensis and Yersinia pestis. The most important bacterial warfare agents - review
    M Pohanka
    Center of Advanced Studies and Department of Toxicology, Faculty of Military Health Sciences, University of Defense, 50 001 Hradec Králové, Czech Republic
    Folia Microbiol (Praha) 54:263-72. 2009
    ..mentioned one; however, Fracisella tularensis (causing tularemia) and Yersinia pestis (the causative agent of plague) are further bacterial agents enlisted by Centers for Disease Control and Prevention into the category A of ..
  92. ncbi Flea diversity and infestation prevalence on rodents in a plague-endemic region of Uganda
    Gerald Amatre
    Uganda Virus Research Institute, Entebbe, Uganda
    Am J Trop Med Hyg 81:718-24. 2009
    In Uganda, the West Nile region is the primary epidemiologic focus for plague. The aims of this study were to 1) describe flea-host associations within a plague-endemic region of Uganda, 2) compare flea loads between villages with or ..
  93. ncbi Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague
    E D Williamson
    Dstl Porton Down, Salisbury, Wilts SP4 0JQ, UK
    Vaccine 25:1142-8. 2007
    ....
  94. pmc Rodent and flea abundance fail to predict a plague epizootic in black-tailed prairie dogs
    Robert Jory Brinkerhoff
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado 80309 0334, USA
    Vector Borne Zoonotic Dis 10:47-52. 2010
    ..for 3 years at a number of prairie dog colony sites in Boulder County, Colorado, before, during, and after a local plague epizootic to see if high rodent or flea abundance was associated with plague-affected colonies when compared to ..
  95. ncbi Plague vaccines and the molecular basis of immunity against Yersinia pestis
    Lauriane E Quenee
    Department of Microbiology, University of Chicago, Chicago, IL, USA
    Hum Vaccin 5:817-23. 2009
    Yersinia pestis is the causative agent of bubonic and pneumonic plague, human diseases with high mortality. Due to the microbe's ability to spread rapidly, plague epidemics present a serious public health threat...
  96. ncbi N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infection
    Jim Hill
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 27:7073-9. 2009
    ..3 and reduced its protective capacity against plague. Since the Mab7...
  97. pmc Predictors for presence and abundance of small mammals in households of villages endemic for commensal rodent plague in Yunnan Province, China
    Jia Xiang Yin
    Yunnan Institute of Endemic Disease Control and Prevention, 5 Wenhua Road, Dali City, Yunnan Province, 671000, PR China
    BMC Ecol 8:18. 2008
    Ninety-one rodent plague epidemics have occurred in Lianghe county, Yunnan Province, China, between 1990 and 2006...
  98. ncbi Immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits
    Tonie E Rocke
    US Geological Survey, National Wildlife Health Center, Madison, Wisconsin 53711, USA
    J Wildl Dis 44:930-7. 2008
    ..are highly susceptible to Yersinia pestis and, along with other wild rodents, are significant reservoirs of plague for other wildlife and humans in the western United States...
  99. pmc Biofilm formation is not required for early-phase transmission of Yersinia pestis
    Sara M Vetter
    Bacterial Diseases Branch, Division of Vector Borne Diseases, National Center for Enteric and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    Microbiology 156:2216-25. 2010
    Early-phase transmission (EPT) is a recently described model of plague transmission that explains the rapid spread of disease from flea to mammal host during an epizootic...
  100. doi Dog-associated risk factors for human plague
    L Hannah Gould
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Bacterial Diseases Branch, Fort Collins, CO, USA
    Zoonoses Public Health 55:448-54. 2008
    b>Plague is a rare but often fatal zoonosis endemic to the western United States. Previous studies have identified contact with pets as a potential risk factor for infection...
  101. doi Flea-associated zoonotic diseases of cats in the USA: bartonellosis, flea-borne rickettsioses, and plague
    Kristina M McElroy
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, 1600 Clifton Road, Atlanta, GA 30333, USA
    Trends Parasitol 26:197-204. 2010
    Cat-scratch disease, flea-borne typhus, and plague are three flea-associated zoonoses of cats of concern in the USA...

Research Grants81

  1. Pacific Southwest RCE for Biodefense & Emerging Infectious Diseases Research
    Alan G Barbour; Fiscal Year: 2010
    ..California has long been a center for the diagnosis and prevention of infant botulism. In its sylvatic form plague is primarily a zoonosis of the western US, and there are prospects for urban outbreaks in the metropolises of Asia...
  2. Pacific-Southwest Ctr for Biodefense & Emerg Infect Dis*
    Alan Barbour; Fiscal Year: 2005
    ..of the programs are anthrax vaccines, arboviruses, arenaviruses, botulinum toxin, Burkholderia, hantaviruses, plague, and tularemia...
  3. Pacific-Southwest Ctr for Biodefense & Emerg Infect Dis*
    Alan Barbour; Fiscal Year: 2006
    ..of the programs are anthrax vaccines, arboviruses, arenaviruses, botulinum toxin, Burkholderia, hantaviruses, plague, and tularemia...
  4. Pacific-Southwest Ctr for Biodefense & Emerg Infect Dis*
    Alan Barbour; Fiscal Year: 2007
    ..of the programs are anthrax vaccines, arboviruses, arenaviruses, botulinum toxin, Burkholderia, hantaviruses, plague, and tularemia...
  5. Bacteriolytic phage enzymes as novel antibacterials against Yersinia pestis
    Ian Molineux; Fiscal Year: 2009
    ..In particular, some isolates of Yersinia pestis, the causative agent of plague, are known to harbor multiple resistance determinants to commonly used antibiotics...
  6. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2005
    Yersinia pestis is the causative agent of plague, a pandemic clinically divided into bubonic, septicemic, and pneumonic diseases...
  7. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague, a pandemic clinically divided into bubonic, septicemic, and pneumonic diseases...
  8. Sphingolipid-mediated skeletal muscle pathology in response to free fatty acids.
    LAUREN COWART; Fiscal Year: 2009
    ..These health problems plague large sections of the population, and type 2 diabetes occurs at a higher rate in veterans than in the general ..
  9. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly Henrickson; Fiscal Year: 2007
    ..threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that ..
  10. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly Henrickson; Fiscal Year: 2006
    ..threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that ..
  11. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly Henrickson; Fiscal Year: 2009
    ..threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that ..
  12. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly Henrickson; Fiscal Year: 2009
    ..threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that ..
  13. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that ..
  14. PLASMIDS AND VIRULENCE IN PLAGUE
    Jon Goguen; Fiscal Year: 1990
    Yersinia pestis is the causative agent of plague, a natural disease of mice, rats, and other rodents which also affects man...
  15. Combinatorial vaccines against anthrax and plague
    John Clements; Fiscal Year: 2004
    ..immunization of civilian and military populations against potential bioterrorism agents, including anthrax and plague, Vaccines combining protective antigens from different microorganisms with potential for use against civilian or ..
  16. Combinatorial vaccines against anthrax and plague
    John Clements; Fiscal Year: 2006
    ..immunization of civilian and military populations against potential bioterrorism agents, including anthrax and plague, Vaccines combining protective antigens from different microorganisms with potential for use against civilian or ..
  17. Combinatorial vaccines against anthrax and plague
    John Clements; Fiscal Year: 2003
    ..immunization of civilian and military populations against potential bioterrorism agents, including anthrax and plague, Vaccines combining protective antigens from different microorganisms with potential for use against civilian or ..
  18. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    Yersinia pestis is a Gram-negative bacillus, which is the etiological agent of plague. Human infection by this pathogen may occur by subcutaneous (e.g...
  19. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie Barnes; Fiscal Year: 2009
    Yersinia pestis is a Gram-negative bacillus, which is the etiological agent of plague. Human infection by this pathogen may occur by subcutaneous (e.g...
  20. Inhaled Aminoglycoside Formulafor Plague and Tularemia
    James Talton; Fiscal Year: 2005
    ..for post-exposure treatment of aerosol exposure of the Category A bioterrorism agents pneumonic Yersina pestis (plague) and Francisella tularensis (tularemia)...
  21. Neural dysfunction and neuroinflammation in African brain disorders
    KRISTER SVEN KRISTENSSON; Fiscal Year: 2010
    ..Infectious diseases of the brain are among the most devastating brain disorders that plague developing countries...
  22. MRCE for Biodefense and Emerging Infectious Dieseases
    Herbert Virgin; Fiscal Year: 2009
    ..research program that crossed institutions and led to seminal discoveries on poxviruses, West Nile Virus and plague. The new Strategic Plan for the MRCE centers on two research themes...
  23. MRCE for Biodefense and Emerging Infectious Dieseases
    Herbert Virgin; Fiscal Year: 2009
    ..research program that crossed institutions and led to seminal discoveries on poxviruses, West Nile Virus and plague. The new Strategic Plan for the MRCE centers on two research themes...
  24. Virulence Mechanisms of Y. pestis and F. tularensis
    DAVID THANASSI; Fiscal Year: 2009
    Seeinstructions): Yersinia pestis and Francisella tularensis are the causative agents of plague and tularemia, respectively...
  25. Yersinia Pestis
    Arnold Louie; Fiscal Year: 2005
    Yersinia pestis, the agent of plague, has been weaponized and is, therefore, a potential agent of bioterror and biowarfare...
  26. Yersinia Pestis
    Arnold Louie; Fiscal Year: 2007
    Yersinia pestis, the agent of plague, has been weaponized and is, therefore, a potential agent of bioterror and biowarfare...
  27. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    Victims of bacterial bioterrorism agents such as anthrax, plague, and tularemia die very often because of septicemia and subsequent multiple organ dysfunction syndrome (MODS)...
  28. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2004
    Victims of bacterial bioterrorism agents such as anthrax, plague, and tularemia die very often because of septicemia and subsequent multiple organ dysfunction syndrome (MODS)...
  29. Multivalent Plague, Anthrax Vaccines Using Bacteriophage T4 Display
    Venigalla B Rao; Fiscal Year: 2010
    ..The major goal of this proposal is to test this hypothesis and develop trivalent plague and multivalent plague-anthrax vaccines that can confer protection against Bacillus anthracis and Yersinia pestis, ..
  30. Multivalent Plague, Anthrax Vaccines Using Bacteriophage T4 Display
    VENIGALLA RAO; Fiscal Year: 2009
    ..The major goal of this proposal is to test this hypothesis and develop trivalent plague and multivalent plague-anthrax vaccines that can confer protection against Bacillus anthracis and Yersinia pestis, ..
  31. Airway Inflammation
    Shawn Skerrett; Fiscal Year: 2003
    ..to airborne infection with gram negative bacteria that are potential biological weapons, including the agents of plague (Yersinia pestis), tularemia (Francisella tularensis) and melioidosis (Burkholderia pseudomallei)...
  32. 2012 International Conference on Anaerobic Parasites (ICAP)
    PATRICIA JEAN JOHNSON; Fiscal Year: 2012
    ..Nevertheless many parasitic diseases still plague developing countries and research directed at understanding these evolutionarily diverse, unicellular eukaryotes ..
  33. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2002
    Yersina pestis, the ethiologic agent of plague or Black Death, has in historical times caused devastating pandemics unrivaled by any other infectious disease...
  34. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2003
    Yersina pestis, the ethiologic agent of plague or Black Death, has in historical times caused devastating pandemics unrivaled by any other infectious disease...
  35. The role of LPS-TLR4 signaling in live vaccine-induced protective responses
    Egil Lien; Fiscal Year: 2009
    ..The gram-negative bacterium Yersinia pestis is the causative agent of plague. Currently there is no available licensed plague vaccine, and exploratory vaccines have variable ability to ..
  36. The role of LPS-TLR4 signaling in live vaccine-induced protective responses
    Egil Lien; Fiscal Year: 2010
    ..The gram-negative bacterium Yersinia pestis is the causative agent of plague. Currently there is no available licensed plague vaccine, and exploratory vaccines have variable ability to ..
  37. Reservoir Vaccines
    Alan Barbour; Fiscal Year: 2009
    ..The field studies will also inform implementation of a reservoir-targeted plague vaccine (Project 7.3). This is a multidisciplinary, multi-institution translational research project...
  38. HTS assay development targeting Yersinia pestis topoisomerase I
    Yuk Ching Tse-Dinh; Fiscal Year: 2011
    ..Yersinia pestis is the causative agent for plague, and multi-drug resistant Y. pestis has the potential to be used as a weapon in future terrorist attacks...
  39. HTS assay development targeting Yersinia pestis topoisomerase I
    Yuk Ching Tse Dinh; Fiscal Year: 2010
    ..Yersinia pestis is the causative agent for plague, and multi-drug resistant Y. pestis has the potential to be used as a weapon in future terrorist attacks...
  40. Clinical Development of Combination Plague/Smallpox Vaccine
    CHARALAMBOS PARTIDOS; Fiscal Year: 2009
    ..b>Plague and smallpox could be devastating bioweapons if intentionally released. A release of 50 kg of Y...
  41. Clinical Development of Combination Plague/Smallpox Vaccine
    CHARALAMBOS PARTIDOS; Fiscal Year: 2010
    ..b>Plague and smallpox could be devastating bioweapons if intentionally released. A release of 50 kg of Y...
  42. Drug Consumption and Disease Mortality: Population-level Analyses
    Siddharth Chandra; Fiscal Year: 2010
    ..intensity of a variety of infectious diseases and conditions (including but not restricted to cholera, smallpox, plague, and diarrhea and dysentery) as well as a rich set of possible epidemiologic correlates...
  43. Phage-mediated bioluminescent detection of Yersinia pestis.
    David Schofield; Fiscal Year: 2009
    ..Y. pestis is the etiological agent of the plague (Black Death), a transmissible disease that has been responsible for millions of deaths throughout the course of ..
  44. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS DICKENSON; Fiscal Year: 2009
    ..S. flexneri along with numerous other important pathogens such as Yersinia pestis (plague), Salmonella (gastroenteritis), and Pseudomonas aeruginosa (lung infection) utilize the type III secretion system (..
  45. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..S. flexneri along with numerous other important pathogens such as Yersinia pestis (plague), Salmonella (gastroenteritis), and Pseudomonas aeruginosa (lung infection) utilize the type III secretion system (..
  46. Immunity to Yersinia Pestis Infections
    ROBERT BRUBAKER; Fiscal Year: 2003
    Yersinia pestis, the causative agent of plague, represents the most feared biological warfare agent, as individuals infected via the respiratory route not only succumb to the disease within 72 hours, but also transmit Y...
  47. Project EXPORT - A Center of Excellence (PEACE)
    Lovell Jones; Fiscal Year: 2009
    ..Today, the issue of what is now termed "health disparities" continues to plague not only African Americans, but also other people of color and the medically underserved, and society struggles ..
  48. Project EXPORT - A Center of Excellence (PEACE)
    LOVELL ALLAN JONES; Fiscal Year: 2010
    ..Today, the issue of what is now termed "health disparities" continues to plague not only African Americans, but also other people of color and the medically underserved, and society struggles ..
  49. IMMUNOGENS OF T PALLIDUM: IDENTIFICATION AND FUNCTION
    Sheila Lukehart; Fiscal Year: 1990
    Syphilis is a chronic bacterial infection which, after five centuries, continues to plague individuals worldwide...
  50. Project EXPORT - A Center of Excellence (PEACE)
    Lovell Jones; Fiscal Year: 2007
    ..Today, the issue of what is now termed "health disparities" continues to plague not only African Americans, but also other people of color and the medically underserved, and society struggles ..
  51. Cambodia: Between the Khmers Rouges and the Red Plague?
    Patrick Heuveline; Fiscal Year: 2002
    ..The existence of this long-term observatory will complement and enhance future substantive research in this population. ..
  52. Neurophysiological and Neuropharmacological Studies of a Parasitic Nematode
    Ralph Davis; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Parasitic nematodes plague the world as major contributors to disease, and anti-parasitic drugs (anthelmintics) are the primary control measure...
  53. Cambodia: Between the Khmers Rouges and the Red Plague?
    Patrick Heuveline; Fiscal Year: 2003
    ..The existence of this long-term observatory will complement and enhance future substantive research in this population. ..
  54. Intracellular survival determinants of Yersinia pestis
    JAMES BLISKA; Fiscal Year: 2009
    Seeinstructions): Pneumonic plague is highly lethal in humans, and the agent of this disease, Y. pestis, is considered a major threat as a biological weapon...
  55. The Role of LPS and Toll-like Receptors in Plague
    Egil Lien; Fiscal Year: 2004
    The Gram-negative bacteria Yersinia pestis is the causative agent of plague, and is classified as an NIAID category A priority biodefense agent. Y...
  56. The Role of LPS and Toll-like Receptors in Plague
    Egil Lien; Fiscal Year: 2007
    The Gram-negative bacteria Yersinia pestis is the causative agent of plague, and is classified as an NIAID category A priority biodefense agent. Y...
  57. The Role of LPS and Toll-like Receptors in Plague
    Egil Lien; Fiscal Year: 2006
    The Gram-negative bacteria Yersinia pestis is the causative agent of plague, and is classified as an NIAID category A priority biodefense agent. Y...
  58. The Role of LPS and Toll-like Receptors in Plague
    Egil Lien; Fiscal Year: 2005
    The Gram-negative bacteria Yersinia pestis is the causative agent of plague, and is classified as an NIAID category A priority biodefense agent. Y...
  59. Mechanism of anti-phagocytosis by Yersinia pestis
    Kristiina Vuori; Fiscal Year: 2005
    Yersinia pestis, the causative agent of plague, is one of the most pathogenic bacteria known to mankind. Due to its high pathogenicity, Yersinia has been recognized as a potential weapon for bioterrorism...
  60. Non-clinical Development of Bactericidal Proteins Targeting Plague
    David Martin; Fiscal Year: 2009
    In our Phase 1 project we have developed R-type pyocins, targetable bactericidal proteins, that kill the plague bacterium, Yersinia pestis, in vitro and are not sensitive to the mechanisms that bacteria use to resist antibiotics...
  61. Mechanism of anti-phagocytosis by Yersinia pestis
    Kristiina Vuori; Fiscal Year: 2004
    Yersinia pestis, the causative agent of plague, is one of the most pathogenic bacteria known to mankind. Due to its high pathogenicity, Yersinia has been recognized as a potential weapon for bioterrorism...
  62. A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Yersinia pestis (Y. pestis), the causative agent of plague, is a Gram-negative bacillus that is classified as a Category A pathogen by the Centers for Disease Control and a logical choice ..
  63. A Salmonella-based Plague Vaccine
    James Nataro; Fiscal Year: 2003
    Yersinia pestis is the causative agent of plague and constitutes an important biowarfare and bioterror agent...
  64. A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Yersinia pestis (Y. pestis), the causative agent of plague, is a Gram-negative bacillus that is classified as a Category A pathogen by the Centers for Disease Control and a logical choice ..
  65. Immunity to plague infections
    Olaf Schneewind; Fiscal Year: 2009
    Yersinia pestis, the highly virulent agent of plague, is a biological weapon. Strategies to prevent plague have been sought for centuries, however neither an FDA approved vaccine nor the molecular basis of plague immunity are established...
  66. Novel antiobiotic development for biodefense
    Michael Johnson; Fiscal Year: 2009
    Bacillus anthracis, Francisella tularensis and Yersinia pestis, the causative agents for anthrax, tularemia and plague, respectively, are all classed as Category A agents due to their potential use in bioterrorism and biowarfare...
  67. Live Attenuated Bacterial Vaccines Against Plaque
    James Nataro; Fiscal Year: 2009
    ..a Salmonella-based platform technology, the ultimate intent of which is to provide protection against anthrax and plague in a single vaccine, combined with protection against typhoid fever provided by the vector itself...
  68. HEMIN STORAGE AND UPTAKE IN YERSINIA PESTIS
    Robert Perry; Fiscal Year: 1999
    ..from applicant's abstract): The pigmentation (Pgm+) phenotype of Yersinia pestis, the causative agent of bubonic plague, originally referred to the ability of cells grown at 26 degrees C to adsorb (or store) sufficient exogenous hemin ..
  69. Development, Production and Evaluation of a Multivalent Adenoviral Plague Vaccine
    CHRIS LENTZ; Fiscal Year: 2009
    ..adenoviral vaccine candidate that elicits a potent immune response against Yersinia pestis, the causative agent of plague. The proposed work is a collaborative effort between the University of Texas Medical Branch (UTMB), Norwell, Inc...
  70. RovA regulon of Yersinia pestis
    VIRGINIA MILLER; Fiscal Year: 2002
    Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality...
  71. RovA regulon of Yersinia pestis
    VIRGINIA MILLER; Fiscal Year: 2003
    Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality...
  72. Aerosol Biology/Small Animal Models
    R Buller; Fiscal Year: 2003
    ..Models Core, hereafter referred to as the ABSAM Core or Core, will provide support for smallpox and pneumonic plague research as these diseases will be the most intensely studied NIAID Category A agents in Region 7...
  73. HOST RANGE DIVERSITY OF BACTERIOPHAGE FOR Y. PESTIS
    David Martin; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Yersinia pestis, the bacterium responsible for plague, is a Category A pathogen, a significant biowarfare agent...
  74. Development of RSK Inhibitors as Novel Therapeutics for Yersinia pestis
    Jeffrey Smith; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of the plague, has been weaponized as an agent of biowarfare. The deliberate release of weaponized Y...
  75. Host Protein Modulation of Type III Secretion
    Ralph R Isberg; Fiscal Year: 2010
    ..Systems, which are critical for causing diseases as common as enteropathogenic diarrhea and as virulent as bubonic plague. These protein translocation systems have a number of conserved components found in a broad swath of pathogens, so ..
  76. Development of RSK Inhibitors as Novel Therapeutics for Yersinia pestis
    Jeffrey Smith; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of the plague, has been weaponized as an agent of biowarfare. The deliberate release of weaponized Y...
  77. Discovery and Preclinical Development of Drugs for Anthrax, Plague and Tularemia
    Christie Brouillette; Fiscal Year: 2009
    ..Infections of anthrax, plague, and tularemia are currently treated with existing antibiotics such as ciprofloxacin and doxycycline...
  78. Discovery and Preclinical Development of Drugs for Anthrax, Plague and Tularemia
    Christie G Brouillette; Fiscal Year: 2010
    ..Infections of anthrax, plague, and tularemia are currently treated with existing antibiotics such as ciprofloxacin and doxycycline...