plague

Summary

Summary: An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.

Top Publications

  1. pmc Plague: past, present, and future
    Nils Chr Stenseth
    Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway
    PLoS Med 5:e3. 2008
  2. pmc A draft genome of Yersinia pestis from victims of the Black Death
    Kirsten I Bos
    McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada
    Nature 478:506-10. 2011
  3. pmc Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
    Giovanna Morelli
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Berlin, Germany
    Nat Genet 42:1140-3. 2010
  4. ncbi Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
    Sara W Montminy
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:1066-73. 2006
  5. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
  6. pmc Plague and climate: scales matter
    Tamara Ben-Ari
    Centre for Ecological and Evolutionary Synthesis CEES, University of Oslo, Oslo, Norway
    PLoS Pathog 7:e1002160. 2011
  7. pmc Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity
    Wyndham W Lathem
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:17786-91. 2005
  8. pmc Climate variability and change in the United States: potential impacts on vector- and rodent-borne diseases
    D J Gubler
    Division of Vectorborne Infectious Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Environ Health Perspect 109:223-33. 2001
  9. pmc Plague outbreaks in prairie dog populations explained by percolation thresholds of alternate host abundance
    Daniel J Salkeld
    Woods Institute for the Environment and Department of Anthropology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14247-50. 2010
  10. pmc Kinetics of innate immune response to Yersinia pestis after intradermal infection in a mouse model
    Christopher F Bosio
    Laboratory of Zoonotic Pathogens, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 80:4034-45. 2012

Detail Information

Publications347 found, 100 shown here

  1. pmc Plague: past, present, and future
    Nils Chr Stenseth
    Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway
    PLoS Med 5:e3. 2008
  2. pmc A draft genome of Yersinia pestis from victims of the Black Death
    Kirsten I Bos
    McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada
    Nature 478:506-10. 2011
    ..pestis infections...
  3. pmc Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
    Giovanna Morelli
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Berlin, Germany
    Nat Genet 42:1140-3. 2010
    b>Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y...
  4. ncbi Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
    Sara W Montminy
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:1066-73. 2006
    At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes lipopolysaccharide (LPS)-lipid A with poor Toll-like receptor 4 (TLR4)-stimulating activity...
  5. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
    b>Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history...
  6. pmc Plague and climate: scales matter
    Tamara Ben-Ari
    Centre for Ecological and Evolutionary Synthesis CEES, University of Oslo, Oslo, Norway
    PLoS Pathog 7:e1002160. 2011
    b>Plague is enzootic in wildlife populations of small mammals in central and eastern Asia, Africa, South and North America, and has been recognized recently as a reemerging threat to humans...
  7. pmc Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity
    Wyndham W Lathem
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:17786-91. 2005
    Although pneumonic plague is the deadliest manifestation of disease caused by the bacterium Yersinia pestis, there is surprisingly little information on the cellular and molecular mechanisms responsible for Y...
  8. pmc Climate variability and change in the United States: potential impacts on vector- and rodent-borne diseases
    D J Gubler
    Division of Vectorborne Infectious Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Environ Health Perspect 109:223-33. 2001
    Diseases such as plague, typhus, malaria, yellow fever, and dengue fever, transmitted between humans by blood-feeding arthropods, were once common in the United States...
  9. pmc Plague outbreaks in prairie dog populations explained by percolation thresholds of alternate host abundance
    Daniel J Salkeld
    Woods Institute for the Environment and Department of Anthropology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14247-50. 2010
    Highly lethal pathogens (e.g., hantaviruses, hendra virus, anthrax, or plague) pose unique public-health problems, because they seem to periodically flare into outbreaks before disappearing into long quiescent phases...
  10. pmc Kinetics of innate immune response to Yersinia pestis after intradermal infection in a mouse model
    Christopher F Bosio
    Laboratory of Zoonotic Pathogens, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 80:4034-45. 2012
    ..Thus, an important feature of Y. pestis infection is reduced activation and organization of inflammatory cells that is at least partially dependent on the pYV virulence plasmid...
  11. pmc Protecting against plague: towards a next-generation vaccine
    E D Williamson
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Salisbury, Wilts, UK
    Clin Exp Immunol 172:1-8. 2013
    The causative organism of plague is the bacterium Yersinia pestis...
  12. ncbi Cynomolgus macaque model for pneumonic plague
    Richard Warren
    Battelle Biomedical Research Center, 505 King Ave, Columbus, OH 43201, USA
    Microb Pathog 50:12-22. 2011
    A recombinant vaccine (rF1V) is currently being developed for protection against pneumonic plague. An essential component in evaluating efficacy of the rF1V vaccine is the development of a well-understood animal model that shows ..
  13. pmc Intraspecific diversity of Yersinia pestis
    Andrey P Anisimov
    Department of Infectious Diseases, State Research Center for Applied Microbiology, 142279 Obolensk, Serpukhov District, Moscow Region, Russia
    Clin Microbiol Rev 17:434-64. 2004
    ..pestis strains based on genetic and phenotypic variation and show that there is a high level of diversity in these strains not reflected by ones obtained from sylvatic areas and patients in the Americas...
  14. ncbi Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host
    Haihong Liu
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
    J Basic Microbiol 49:92-9. 2009
    Despite the importance of pneumonic plague caused by Yersinia pestis, a few is known about the interaction between Y. pestis and its host at the molecular level during the pneumonic plague development...
  15. pmc Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death
    Verena J Schuenemann
    Institut für Naturwissenschaftliche Archäologie, University of Tubingen, 72072 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:E746-52. 2011
    Although investigations of medieval plague victims have identified Yersinia pestis as the putative etiologic agent of the pandemic, methodological limitations have prevented large-scale genomic investigations to evaluate changes in the ..
  16. pmc Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague
    Florent Sebbane
    Laboratory of Zoonotic Pathogens and Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:5526-30. 2006
    Yersinia pestis is transmitted by fleas and causes bubonic plague, characterized by severe local lymphadenitis that progresses rapidly to systemic infection and life-threatening septicemia...
  17. pmc Molecular identification by "suicide PCR" of Yersinia pestis as the agent of medieval black death
    D Raoult
    Centre National de la Recherche Scientifique Unité Propre de Recherche de l Enseignement Superieur UPRES A 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille, France
    Proc Natl Acad Sci U S A 97:12800-3. 2000
    ..It was identified as plague at this time, but recently the causative organism was debated because no definitive evidence has been obtained to ..
  18. pmc Pathogenesis of Yersinia pestis infection in BALB/c mice: effects on host macrophages and neutrophils
    Roman A Lukaszewski
    Department of Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire, SP4 0JQ, United Kingdom
    Infect Immun 73:7142-50. 2005
    The pathogenesis of infection with Yersinia pestis, the causative agent of plague, was examined following subcutaneous infection of BALB/c mice with a fully virulent strain expressing green fluorescent protein...
  19. pmc RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague
    Jason S Cathelyn
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:13514-9. 2006
    ..p. route, indicating a more important role for RovA in bubonic plague than pneumonic plague or systemic infection. Microarray analysis was used to define the RovA regulon...
  20. ncbi Poor vector competence of fleas and the evolution of hypervirulence in Yersinia pestis
    Ellen A Lorange
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 191:1907-12. 2005
    ..indicated that arthropodborne transmission is an evolutionarily recent adaptation in Yersinia pestis, the agent of plague. We show that the infectivity of Y...
  21. ncbi Museums and disease: using tissue archive and museum samples to study pathogens
    Kyriakos Tsangaras
    Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
    Ann Anat 194:58-73. 2012
    ..This article reviews the advantages, problems, and failures of ancient microbiological research...
  22. pmc Distinct clones of Yersinia pestis caused the black death
    Stephanie Haensch
    Institute for Anthropology, Johannes Gutenberg University, Mainz, Germany
    PLoS Pathog 6:e1001134. 2010
    ..It has also been disputed whether plague had the same etiology in northern and southern Europe...
  23. ncbi Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague
    Yoonkyung Do
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065 6399, USA
    Eur J Immunol 40:2791-6. 2010
    To help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis LcrV protein directly to CD8α(+) DEC-205(+) or CD8α(-) DCIR2(+) DC along with a clinically feasible adjuvant, poly IC. By studying Y...
  24. pmc Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague
    Jr Shiuan Lin
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 187:897-904. 2011
    ..Several of the highest priority bioterror concerns, including anthrax, tularemia, and plague, are caused by bacteria that acutely infect the lung...
  25. ncbi Yersinia pestis and the plague of Justinian 541-543 AD: a genomic analysis
    David M Wagner
    Center for Microbial Genetics and Genomics and Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA
    Lancet Infect Dis 14:319-26. 2014
    Yersinia pestis has caused at least three human plague pandemics...
  26. pmc Plague gives surprises in the first decade of the 21st century in the United States and worldwide
    Thomas Butler
    Ross University School of Medicine, Portsmouth, Dominica, West Indies
    Am J Trop Med Hyg 89:788-93. 2013
    b>Plague is an ancient disease caused by the bacterium Yersinia pestis and transmitted by rodent flea bites that continues to surprise us with first-ever events...
  27. pmc Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation
    Paul A Price
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:3083-8. 2012
    Disease progression of primary pneumonic plague is biphasic, consisting of a preinflammatory and a proinflammatory phase...
  28. pmc Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague
    Zhan Ye
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Infect Immun 79:674-87. 2011
    We are using a systemic plague model to identify the cells and pathways that are undermined by the virulence protein YopM of the plague bacterium Yersinia pestis...
  29. pmc Imaging of bubonic plague dynamics by in vivo tracking of bioluminescent Yersinia pestis
    Toan Nham
    Yersinia Research Unit, Institut Pasteur, Paris, France
    PLoS ONE 7:e34714. 2012
    ..In this work we used in vivo bioluminescence imaging (BLI) to follow Y. pestis dissemination during bubonic plague. We first demonstrated that Y...
  30. pmc High throughput, multiplexed pathogen detection authenticates plague waves in medieval Venice, Italy
    Thi Nguyen Ny Tran
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD 198, IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    PLoS ONE 6:e16735. 2011
    Historical records suggest that multiple burial sites from the 14th-16th centuries in Venice, Italy, were used during the Black Death and subsequent plague epidemics.
  31. pmc Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague
    Claire A Cornelius
    Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
    Infect Immun 76:5588-97. 2008
    ..macaques immunized with rLcrV, rV10, or rF1, either alone or in combination, conferred protection against bubonic plague challenge in mice...
  32. pmc Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague
    Florent Sebbane
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 103:11766-71. 2006
    Yersinia pestis causes bubonic plague, characterized by an enlarged, painful lymph node, termed a bubo, that develops after bacterial dissemination from a fleabite site...
  33. pmc Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
    M Achtman
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 96:14043-8. 1999
    b>Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis. In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic Yersinia species, Y...
  34. pmc Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis
    G W Anderson
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Infect Immun 64:4580-5. 1996
    ..Immunization protected mice from lethal bubonic and pneumonic plague caused by CO92, a wild-type F1+ strain, or by the isogenic F1- strain C12...
  35. pmc TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague
    Jr Shiuan Lin
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Vaccine 29:357-62. 2010
    ..with the Yersinia pestis F1 and LcrV proteins improves survival in mouse and non-human primate models of pneumonic plague. F1- and LcrV-specific antibodies contribute to protection, however, the mechanisms of antibody-mediated defense ..
  36. ncbi From the recent lessons of the Malagasy foci towards a global understanding of the factors involved in plague reemergence
    Jean Marc Duplantier
    Programme RAMSE, IRD Madagascar, Madagascar
    Vet Res 36:437-53. 2005
    Re-emergence of human cases of plague after decades of silence does not necessarily mean that plague foci are re-emerging. Most often, Yersinia pestis bacteria have been maintained and circulating at low levels in the rodent populations...
  37. pmc Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 5:e1319. 2011
    b>Plague was introduced to Madagascar in 1898 and continues to be a significant human health problem...
  38. pmc Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis
    R William DePaolo
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 4:350-61. 2008
    ..However, TLR2-/- mice are not protected against subcutaneous plague infection...
  39. pmc Assessing human risk of exposure to plague bacteria in northwestern Uganda based on remotely sensed predictors
    Rebecca J Eisen
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80522, USA
    Am J Trop Med Hyg 82:904-11. 2010
    b>Plague, a life-threatening flea-borne zoonosis caused by Yersinia pestis, has most commonly been reported from eastern Africa and Madagascar in recent decades...
  40. pmc Kinetics of disease progression and host response in a rat model of bubonic plague
    Florent Sebbane
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Am J Pathol 166:1427-39. 2005
    b>Plague, caused by the gram-negative bacterium Yersinia pestis, primarily affects rodents but is also an important zoonotic disease of humans...
  41. pmc Immune defense against pneumonic plague
    Stephen T Smiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 225:256-71. 2008
    ..Inhalation of this Gram-negative bacterium causes pneumonic plague, a rapidly progressing and usually fatal disease. Extensively antibiotic-resistant strains of Y...
  42. pmc Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo
    Eric Bertherat
    World Health Organization, Geneva, Switzerland
    Emerg Infect Dis 17:778-84. 2011
    Pneumonic plague is a highly transmissible infectious disease for which fatality rates can be high if untreated; it is considered extremely lethal. Without prompt diagnosis and treatment, disease management can be problematic...
  43. pmc Yersinia--flea interactions and the evolution of the arthropod-borne transmission route of plague
    Iman Chouikha
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Curr Opin Microbiol 15:239-46. 2012
    Yersinia pestis, the causative agent of plague, is unique among the enteric group of Gram-negative bacteria in relying on a blood-feeding insect for transmission...
  44. ncbi Susceptibility to plague of the rodents in Antananarivo, Madagascar
    Lila Rahalison
    Institut Pasteur de Madagascar Centre Collaborateur OMS, BP 1274, Antananarivo, BP 1274 Antananarivo, Madagascar
    Adv Exp Med Biol 529:439-42. 2003
  45. ncbi Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan
    T Leslie
    Health Protection and Research Organisation, Kabul, Afghanistan
    Epidemiol Infect 139:728-35. 2011
    b>Plague, which is most often caused by the bite of Yersinia pestis-infected fleas, is a rapidly progressing, serious disease that can be fatal without prompt antibiotic treatment...
  46. pmc Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague
    Kristen N Peters
    Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA
    PLoS Pathog 9:e1003324. 2013
    Yersinia pestis causes pneumonic plague, a disease characterized by inflammation, necrosis and rapid bacterial growth which together cause acute lung congestion and lethality...
  47. pmc Protection against aerosolized Yersinia pestis challenge following homologous and heterologous prime-boost with recombinant plague antigens
    Audrey Glynn
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, 1430 Tulane Avenue, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Infect Immun 73:5256-61. 2005
    ..pestis, (ii) parenteral immunization is not required to protect mice against aerosolized plague challenge, (iii) the route of immunization and choice of adjuvant influence the magnitude of the antibody response ..
  48. ncbi A Toll/interleukin (IL)-1 receptor domain protein from Yersinia pestis interacts with mammalian IL-1/Toll-like receptor pathways but does not play a central role in the virulence of Y. pestis in a mouse model of bubonic plague
    Abigail M Spear
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, UK
    Microbiology 158:1593-606. 2012
    ..we investigate a TIR domain protein from the highly virulent bacterium Yersinia pestis, the causative agent of plague. When overexpressed in vitro this protein is able to downregulate IL-1β- and LPS-dependent signalling to NFκB ..
  49. pmc Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis
    Anna N Honko
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Infect Immun 74:1113-20. 2006
    ..of adaptive immunity, we evaluated the efficacy of recombinant Salmonella flagellin as an adjuvant in an acellular plague vaccine...
  50. ncbi Climate change effects on plague and tularemia in the United States
    Yoshinori Nakazawa
    Natural History Museum and Biodiversity Research Center, The University of Kansas, Lawrence, Kansas 66045, USA
    Vector Borne Zoonotic Dis 7:529-40. 2007
    b>Plague and tularemia are serious zoonotic diseases endemic to North America. We evaluated spatial patterns in their transmission in view of changing climates...
  51. pmc Role of the Yersinia pestis yersiniabactin iron acquisition system in the incidence of flea-borne plague
    Florent Sebbane
    Equipe Peste et Yersinia pestis, Centre d Infection et d Immunité de Lille, Institut Pasteur de Lille, Lille, France
    PLoS ONE 5:e14379. 2010
    b>Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis. Y...
  52. pmc Novel genetic tools for diaminopimelic acid selection in virulence studies of Yersinia pestis
    David M Bland
    Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America
    PLoS ONE 6:e17352. 2011
    ..The dapAX mutation rendered Y. pestis avirulent in mouse models of bubonic and septicemic plague which could be complemented when dapAX was inserted in single or multi-copy, restoring development of disease that ..
  53. ncbi Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice
    Christian E Demeure
    Yersinia Research Unit, Institut Pasteur, Paris, France
    J Infect Dis 205:134-43. 2012
    ..mice are usually highly susceptible to Yersinia pestis, we recently identified a mouse strain (SEG) that exhibited an exceptional capacity to resist bubonic plague and used it to identify immune mechanisms associated with resistance.
  54. pmc Role of the Yersinia pestis Ail protein in preventing a protective polymorphonuclear leukocyte response during bubonic plague
    B Joseph Hinnebusch
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 79:4984-9. 2011
    The ability of Yersinia pestis to forestall the mammalian innate immune response is a fundamental aspect of plague pathogenesis. In this study, we examined the effect of Ail, a 17-kDa outer membrane protein that protects Y...
  55. pmc IL-17 contributes to cell-mediated defense against pulmonary Yersinia pestis infection
    Jr Shiuan Lin
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 186:1675-84. 2011
    Pneumonic plague is one of the world's most deadly infectious diseases. The causative bacterium, Yersinia pestis, has the potential to be exploited as a biological weapon, and no vaccine is available...
  56. pmc Genotyping, Orientalis-like Yersinia pestis, and plague pandemics
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 10:1585-92. 2004
    Three pandemics have been attributed to plague in the last 1,500 years. Yersinia pestis caused the third, and its DNA was found in human remains from the second. The Antiqua biovar of Y...
  57. ncbi Genome sequence of Yersinia pestis, the causative agent of plague
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 413:523-7. 2001
    ..Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black ..
  58. pmc A live attenuated strain of Yersinia pestis KIM as a vaccine against plague
    Wei Sun
    Center for Infectious Disease and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Vaccine 29:2986-98. 2011
    Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y...
  59. ncbi Plague in Mongolia
    Bolormaa Galdan
    National Center for Infectious Diseases with Natural Foci, Songinokhairkhan District, Ulaanbaatar, Mongolia
    Vector Borne Zoonotic Dis 10:69-75. 2010
    ..7 million people. The geography of Mongolia is varied and has a continental climate. Plague, caused by the bacterium Yersinia pestis, is enzootic in wild rodent populations over large rural areas of ..
  60. pmc Amino acid residues 196-225 of LcrV represent a plague protective epitope
    Lauriane E Quenee
    Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Vaccine 28:1870-6. 2010
    ..protein that resides at the tip of the type III secretion needles of Yersinia pestis, is the single most important plague protective antigen. Earlier work reported monoclonal antibody MAb 7...
  61. pmc The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background
    Eric H Weening
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    Infect Immun 79:644-52. 2011
    Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y...
  62. pmc MLVA distribution characteristics of Yersinia pestis in China and the correlation analysis
    Xiaoai Zhang
    National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, PR China
    BMC Microbiol 9:205. 2009
    Yersinia pestis, the aetiological agent of plague, has been well defined genotypically on local and worldwide scales...
  63. ncbi The abundance threshold for plague as a critical percolation phenomenon
    S Davis
    Theoretical Epidemiology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 7, 3584 CL Utrecht, The Netherlands
    Nature 454:634-7. 2008
    ..Archived records of plague (infection with Yersinia pestis) in populations of great gerbils (Rhombomys opimus) in Kazakhstan have been used ..
  64. pmc Transcriptomic and innate immune responses to Yersinia pestis in the lymph node during bubonic plague
    Jason E Comer
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 78:5086-98. 2010
    ..inflammatory response is a prominent feature of infection with Yersinia pestis, the agent of bubonic and pneumonic plague. Using a rat model of bubonic plague, we examined lymph node histopathology, transcriptome, and extracellular ..
  65. ncbi Design and testing for a nontagged F1-V fusion protein as vaccine antigen against bubonic and pneumonic plague
    Bradford S Powell
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 1201, USA
    Biotechnol Prog 21:1490-510. 2005
    ..pestis challenge strains, modeling prophylaxis against pneumonic and bubonic plague. These findings confirm that the fusion protein architecture provides superior protection over the former licensed ..
  66. pmc Outer membrane protein X (Ail) contributes to Yersinia pestis virulence in pneumonic plague and its activity is dependent on the lipopolysaccharide core length
    Anna M Kolodziejek
    Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844 3052, USA
    Infect Immun 78:5233-43. 2010
    Yersinia pestis, the causative agent of plague, is one of the most virulent microorganisms known. The outer membrane protein X (OmpX) in Y...
  67. pmc Syndromic surveillance and bioterrorism-related epidemics
    James W Buehler
    Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Emerg Infect Dis 9:1197-204. 2003
  68. pmc Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium
    Mark Eppinger
    Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Bacteriol 192:1685-99. 2010
    To gain insights into the origin and genome evolution of the plague bacterium Yersinia pestis, we have sequenced the deep-rooted strain Angola, a virulent Pestoides isolate...
  69. ncbi Plague
    E D Williamson
    Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wilts SP4 0JQ, UK
    Vaccine 27:D56-60. 2009
    Killed whole cell vaccines for plague were first produced as long ago as the late 1890s and modified versions of these are still used, with evidence that they are efficacious against bubonic plague...
  70. pmc The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague
    Avital Tidhar
    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
    PLoS ONE 4:e7023. 2009
    Yersinia pestis is the causative agent of plague. Previously we have isolated an attenuated Y. pestis transposon insertion mutant in which the pcm gene was disrupted...
  71. pmc Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA
    Mol Microbiol 79:533-51. 2011
    ..We report that a mutant incapable of c-di-GMP synthesis is unaffected in virulence in plague mouse models...
  72. ncbi A 12-case outbreak of pharyngeal plague following the consumption of camel meat, in north-eastern Jordan
    A Arbaji
    Ministry of Health, P O Box 86, Amman, and Department of Biological Sciences, Jordan University of Science and Technology, Irbid, Jordan
    Ann Trop Med Parasitol 99:789-93. 2005
    Between late January and early February 1997, an outbreak of plague, associated with cervical lymphadenopathy and fever, occurred in the Jordanian village of Azraq ad-Druze, which lies about 50 km west of the border with Saudi Arabia...
  73. ncbi Neutrophils are important in early control of lung infection by Yersinia pestis
    Thomas R Laws
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, UK
    Microbes Infect 12:331-5. 2010
    In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils from naïve BALB/c mice were found to reduce numbers of culturable Yersinia pestis strain GB in suspension...
  74. pmc Yersinia pestis caf1 variants and the limits of plague vaccine protection
    Lauriane E Quenee
    Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
    Infect Immun 76:2025-36. 2008
    Yersinia pestis, the highly virulent agent of plague, is a biological weapon...
  75. pmc Yersinia pestis biofilm in the flea vector and its role in the transmission of plague
    B J Hinnebusch
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIH, NIAID, Hamilton, MT 59840, USA
    Curr Top Microbiol Immunol 322:229-48. 2008
    ..by fleabite is a relatively recent evolutionary adaptation of Yersinia pestis, the bacterial agent of bubonic plague. To produce a transmissible infection, Y. pestis grows as an attached biofilm in the foregut of the flea vector...
  76. pmc Yersinia pestis Orientalis in remains of ancient plague patients
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:332-3. 2007
    Yersinia pestis DNA was recently detected in human remains from 2 ancient plague pandemics in France and Germany. We have now sequenced Y pestis glpD gene in such remains, showing a 93-bp deletion specific for biotype Orientalis...
  77. pmc Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague
    Ayelet Zauberman
    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
    PLoS ONE 4:e5938. 2009
    ..Previous observations have indicated that Yersinia pestis, the causative agent of plague disease, exhibits restricted capacity to induce cell death in macrophages due to ineffective translocation of the ..
  78. pmc Defective innate cell response and lymph node infiltration specify Yersinia pestis infection
    Françoise Guinet
    Unité des Yersinia, Institut Pasteur, Paris, France
    PLoS ONE 3:e1688. 2008
    Since its recent emergence from the enteropathogen Yersinia pseudotuberculosis, Y. pestis, the plague agent, has acquired an intradermal (id) route of entry and an extreme virulence...
  79. pmc Pneumonic plague pathogenesis and immunity in Brown Norway rats
    Deborah M Anderson
    Department of Veterinary Pathobiology, University of Missouri, 302 Connaway Hall, 1600 E Rollins St, Columbia, MO 65211, USA
    Am J Pathol 174:910-21. 2009
    The Brown Norway rat was recently described as a bubonic plague model that closely mimics human disease...
  80. ncbi Herpesvirus latency confers symbiotic protection from bacterial infection
    Erik S Barton
    Departments of Pathology and Immunology, Washington University Medical School, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 447:326-9. 2007
    ..Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host...
  81. pmc Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV
    Kristin L Debord
    Department of Microbiology, University of Chicago, 920 E 58th Street, Chicago, Illinois 60637, USA
    Infect Immun 74:4910-4. 2006
    ..Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.
  82. pmc The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague
    Jacqueline D Fetherston
    Department of Microbiology, Immunology, and Molecular Genetics, MS415 Medical Center, University of Kentucky, Lexington, KY 40536 0298, USA
    Infect Immun 78:2045-52. 2010
    ..lactoferrin and examined the importance of the Ybt system for virulence in mouse models of bubonic and pneumonic plague. Y...
  83. pmc Multiple antimicrobial resistance in plague: an emerging public health risk
    Timothy J Welch
    National Center for Cool and Cold Water Aquaculture, Agricultural Research Service, United States Department of Agriculture USDA, Kearneysville, West Virginia, United States of America
    PLoS ONE 2:e309. 2007
    ..a self-transmissible plasmid (pIP1202) that conferred resistance to many of the antimicrobials recommended for plague treatment and prophylaxis. Comparative analysis of the DNA sequence of Y...
  84. pmc The Yersinia pestis caf1M1A1 fimbrial capsule operon promotes transmission by flea bite in a mouse model of bubonic plague
    Florent Sebbane
    Institut National de la Sante et de la Recherche Medicale, U801, Institut Pasteur de Lille, Lille, France
    Infect Immun 77:1222-9. 2009
    b>Plague is a zoonosis transmitted by fleas and caused by the gram-negative bacterium Yersinia pestis. During infection, the plasmidic caf1M1A1 operon that encodes the Y...
  85. pmc Genotyping and phylogenetic analysis of Yersinia pestis by MLVA: insights into the worldwide expansion of Central Asia plague foci
    Yanjun Li
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 4:e6000. 2009
    ....
  86. ncbi Transcriptome analysis of Yersinia pestis in human plasma: an approach for discovering bacterial genes involved in septicaemic plague
    Sylvie Chauvaux
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Microbiology 153:3112-24. 2007
    Yersinia pestis is the aetiologic agent of plague. Without appropriate treatment, the pathogen rapidly causes septicaemia, the terminal and fatal phase of the disease...
  87. pmc yadBC of Yersinia pestis, a new virulence determinant for bubonic plague
    Stanislav Forman
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Infect Immun 76:578-87. 2008
    ..pestis adherence, invasion, and virulence. We found that loss of yadBC caused a modest loss of invasiveness for epithelioid cells and a large decrease in virulence for bubonic plague but not for pneumonic plague in mice.
  88. ncbi Characterization of the rat pneumonic plague model: infection kinetics following aerosolization of Yersinia pestis CO92
    Stacy L Agar
    Departments of Microbiology and Immunology, UTMB, 301 University Boulevard, MRB 3 142H, Galveston, TX 77555 1070, USA
    Microbes Infect 11:205-14. 2009
    Yersinia pestis, the causative agent of human bubonic and pneumonic plague, is spread during natural infection by the fleas of rodents...
  89. ncbi Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague
    Xinghong Yang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 178:1059-67. 2007
    ..Salmonella-(F1+V)Ags elicited elevated Ab titers similar to their monotypic derivatives. For bubonic plague, mice dosed with Salmonella-(F1+V)Ags and Salmonella-F1-Ag showed similar efficacy (>83% survival) against ..
  90. pmc LcrV plague vaccine with altered immunomodulatory properties
    Katie A Overheim
    Department of Microbiology, University of Chicago, CLSC607B, 920 East 58th Street, Chicago, IL 60637, USA
    Infect Immun 73:5152-9. 2005
    Yersinia pestis, the causative agent of plague, secretes LcrV (low-calcium-response V or V antigen) during infection...
  91. ncbi A horizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillus
    Anne Derbise
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 63:1145-57. 2007
    Yersinia pestis, the plague bacillus, has an exceptional pathogenicity but the factors responsible for its extreme virulence are still unknown...
  92. pmc Improvement of disease prediction and modeling through the use of meteorological ensembles: human plague in Uganda
    Sean M Moore
    National Center for Atmospheric Research, Boulder, Colorado, United States of America
    PLoS ONE 7:e44431. 2012
    ..Our model system focuses on plague (Yersinia pestis infection) in the West Nile region of Uganda...
  93. ncbi Vaccination with F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against plague upon oral challenge with Yersinia pestis
    Tonie E Rocke
    US Geological Survey, National Wildlife Health Center, 6006 Schroeder Road, Madison, WI 53711, USA
    J Wildl Dis 44:1-7. 2008
    ..ferrets (Mustela nigripes) with F1-V fusion protein by subcutaneous (SC) injection protects the animals against plague upon injection of the bacterium Yersinia pestis...
  94. ncbi Mutations, mutation rates, and evolution at the hypervariable VNTR loci of Yersinia pestis
    Amy J Vogler
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    Mutat Res 616:145-58. 2007
    ..closely related isolates of recently emerged clonal pathogens, including Yersinia pestis the etiologic agent of plague, because of their great diversity...
  95. pmc Yersinia pestis subverts the dermal neutrophil response in a mouse model of bubonic plague
    Jeffrey G Shannon
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutesof Health, Hamilton, Montana, USA
    MBio 4:e00170-13. 2013
    ..There, the pathogen replicates to large numbers, causing the pathognomonic bubo of bubonic plague. In this study, several cytometric and microscopic techniques were used to characterize the early host response to ..
  96. ncbi Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar
    C Tollenaere
    IRD, UMR CBGP INRA IRD Cirad Montpellier SupAgro, Campus International de Baillarguet, CS 30016, 34988 Montferrier sur Lez Cedex, France
    Ecohealth 7:242-7. 2010
    In Madagascar, the black rat, Rattus rattus, is the main reservoir of plague (Yersinia pestis infection), a disease still responsible for hundreds of cases each year in this country...
  97. pmc Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines
    Lauriane E Quenee
    Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Vaccine 29:6572-83. 2011
    Yersinia pestis causes plague, a disease with high mortality in humans that can be transmitted by fleabite or aerosol. A US Food and Drug Administration (FDA)-licensed plague vaccine is currently not available...
  98. pmc A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague
    Jian Sha
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA
    Microb Pathog 55:39-50. 2013
    ..Yersinia pestis is a Gram-negative bacterium capable of causing bubonic, septicemic, and pneumonic plague. In this study, we compared the conventional counting of bacterial colony forming units (cfu) in the various ..
  99. ncbi An outbreak of plague including cases with probable pneumonic infection, Ecuador, 1998
    J M Gabastou
    PAHO WHO, Quito, Ecuador
    Trans R Soc Trop Med Hyg 94:387-91. 2000
    ..pestis, the aetiological agent of plague, in 3 contacts from the first community and 1 from the second...
  100. pmc The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague
    Jacqueline D Fetherston
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA
    Infect Immun 80:3880-91. 2012
    ..An feoB mutation alone had no effect on the virulence of Y. pestis in either bubonic or pneumonic plague models...
  101. pmc Hfq-dependent, co-ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis
    Lauren E Bellows
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA
    Mol Microbiol 86:661-74. 2012
    Yersinia pestis, the cause of the disease plague, forms biofilms to enhance flea-to-mammal transmission...

Research Grants76

  1. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..neoglycosides) to address this need and also to provide new products for the therapy of Select Agents, such as Plague, Anthrax and pathogens such as Burkholderia mallei and pseudomallei...
  2. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    Yersinia pestis is a Gram-negative bacillus, which is the etiological agent of plague. Human infection by this pathogen may occur by subcutaneous (e.g...
  3. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA viruses that ..
  4. Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Jeffrey E Saffitz; Fiscal Year: 2010
    ..RELEVANCE: This project is designed to advance our understanding of sudden cardiac death, a major public health plague. We will study a rare heart disease that carries the greatest known risk of sudden death and use a novel model ..
  5. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Depression, fatigue, cognitive dysfunction and other behavioral alterations plague patients with a variety of medical disorders and are associated with reduced treatment adherence and poor health ..
  6. Plague biofilm formation--regulation and function
    ROBERT DONALD PERRY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague which has caused widespread loss of human life during recurrent pandemics...
  7. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis is the infectious agent of bubonic plague, however it can also cause pneumonic and septicemic plague...
  8. HTS assay development targeting Yersinia pestis topoisomerase I
    Yuk Ching Tse-Dinh; Fiscal Year: 2011
    ..Yersinia pestis is the causative agent for plague, and multi-drug resistant Y. pestis has the potential to be used as a weapon in future terrorist attacks...
  9. Isolation of new phage enzymes to kill B. anthracis
    Vincent A Fischetti; Fiscal Year: 2013
    ..similar occurrences in other Category A biological agents with extended soil phases, like Yersinia pestis (the plague agent) and Francisella tularensis (the tularemia agent)...
  10. Regulation of Pore Formation by Type III Secretion System
    Gloria I Viboud; Fiscal Year: 2010
    ..pestis, the etiological agent of bubonic and pneumonic plague. In Yersinia, the TTSS is composed of a needle-like structure, three translocator proteins involved in the ..
  11. Identification of New Antigens for a Plague Vaccine
    Ashok K Chopra; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Historically, plague is one of the most devastating epidemic diseases known to mankind (second only to smallpox), resulting overall in more than 200 million deaths related to three recorded plague ..
  12. NOVEL THERAPEUTICS FOR PRION DISEASES
    Stanley B Prusiner; Fiscal Year: 2013
    ..Because of problems that plague prion-infected cultured cell assays, we propose to develop additional assays for HTS that include adaptation of an ..
  13. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..S. flexneri along with numerous other important pathogens such as Yersinia pestis (plague), Salmonella (gastroenteritis), and Pseudomonas aeruginosa (lung infection) utilize the type III secretion system (..
  14. Cell-mediated protection against pneumonic plague
    Jr Shiuan Lin; Fiscal Year: 2013
    ..one of the world's most virulent human pathogens - is the gram-negative bacterium that causes pneumonic plague. Virulent, antibiotic-resistant, Yp strains exist and Cold War scientists devised means to effectively aerosolize ..
  15. Disease Mechanisms in ARVC
    Jeffrey E Saffitz; Fiscal Year: 2013
    ..RELEVANCE: This project is designed to advance our understanding of sudden cardiac death, a major public health plague, by defining fundamental mechanisms responsible for arrhythmogenic right ventricular cardiomyopathy (ARVC)...
  16. Evaluation of Ail as a protective immunogen for plague
    Eric S Krukonis; Fiscal Year: 2012
    ..Due to the major role of Ail in plague pathogenesis, we propose to use a recently purified Ail protein to determine the ability of Ail immunization to ..
  17. High Throughput Crystallization / Imaging System
    Lawrence J Delucas; Fiscal Year: 2013
    ..developing inhibitors for protein targets associated with diseases such as cancer, cystic fibrosis, anthrax, plague, tularemia, viral influenza and tuberculosis...
  18. Immunotherapeutic Potential of Modified Lipooligosaccharides and Lipid A's
    Robert K Ernst; Fiscal Year: 2013
    ..such as influenza, tuberculosis, and malaria, as well as potential release of bioweaponized agents which cause plague, tularemia, and meilloidosis require vaccines that generate humoral and T-cell responses...
  19. Multivalent Plague, Anthrax Vaccines Using Bacteriophage T4 Display
    Venigalla B Rao; Fiscal Year: 2013
    ..The major goal of this proposal is to test this hypothesis and develop trivalent plague and multivalent plague-anthrax vaccines that can confer protection against Bacillus anthracis and Yersinia pestis, ..
  20. Role of the Plasminogen Activator Protease during Pneumonic Plague
    Wyndham W Lathem; Fiscal Year: 2013
    ..The Gram-negative bacterium Yersinia pestis causes the disease plague, which can manifest in three distinct forms: bubonic, septicemic, and pneumonic. If untreated, Y...
  21. 2012 International Conference on Anaerobic Parasites (ICAP)
    PATRICIA JEAN JOHNSON; Fiscal Year: 2012
    ..Nevertheless many parasitic diseases still plague developing countries and research directed at understanding these evolutionarily diverse, unicellular eukaryotes ..
  22. Discovery and Preclinical Development of Drugs for Anthrax, Plague and Tularemia
    Christie G Brouillette; Fiscal Year: 2010
    ..Infections of anthrax, plague, and tularemia are currently treated with existing antibiotics such as ciprofloxacin and doxycycline...
  23. Non-clinical Development of Bactericidal Proteins Targeting Plague
    DAVID WILLIAM MARTIN; Fiscal Year: 2010
    In our Phase 1 project we have developed R-type pyocins, targetable bactericidal proteins, that kill the plague bacterium, Yersinia pestis, in vitro and are not sensitive to the mechanisms that bacteria use to resist antibiotics...
  24. Molecular Basis of CD1d1 and Natural T Cell Function
    Sebastian Joyce; Fiscal Year: 2013
    ..impact how we concoct iNKT cell-based therapies and vaccines and design vaccination strategies to pathogens that plague human kind...
  25. Clinical Development of Combination Plague/Smallpox Vaccine
    CHARALAMBOS PARTIDOS; Fiscal Year: 2011
    ..b>Plague and smallpox could be devastating bioweapons if intentionally released. A release of 50 kg of Y...
  26. Novel antiobiotic development for biodefense
    Michael E Johnson; Fiscal Year: 2010
    Bacillus anthracis, Francisella tularensis and Yersinia pestis, the causative agents for anthrax, tularemia and plague, respectively, are all classed as Category A agents due to their potential use in bioterrorism and biowarfare...
  27. NMR studies of heterocyclization and epimerization in yersiniabactin synthesis
    DOMINIQUE PASCAL FRUEH; Fiscal Year: 2013
    ..Ybt), a virulence factor found in pathogens such as Yersinia pestis, the causative agent of the bubonic plague, Y. enterocolitica, a food pathogen, and uropathogenic E. coli, responsible for urinary tract infections...
  28. The Psp response of Yersinia enterocolitica
    Andrew J Darwin; Fiscal Year: 2013
    ..Y. pestis causes the infamous disease Plague, which has regained prominence in public awareness due to its potential use as an agent of bioterrorism...
  29. Modulation of Inflammasome Activation by Yersinia
    Igor E Brodsky; Fiscal Year: 2013
    ..we use Yersinia pseudotuberculosis, which expresses many of the same virulence factors as its close relative and plague pathogen Yersinia pestis, as a model to understand the host- pathogen interface and discover shared features of ..
  30. NON-INVASIVE SALIVARY ASSESSMENT OF PREDIABETES AND DIABETES
    Srinivasa R Nagalla; Fiscal Year: 2010
    ..hospital visits that are an issue for disadvantaged populations, contributing to the health disparities that plague diabetes testing, care, and prevention...
  31. CTRIP Ex-vivo perfusion and ventilation of lungs to assess transplant suitability
    Thomas M Egan; Fiscal Year: 2010
    ..This project addresses two major problems that plague LTX as a therapy for patients with end-stage lung disease - far too few suitable lungs for transplant, and graft ..
  32. Evaluating the Progression of Pneumonic Plague
    Roger Pechous; Fiscal Year: 2012
    Pneumonic plague results from the inhalation of the bacterium Yersinia pestis. Due to its lethality, rapid disease progression, and ability to be disseminated via aerosolization, Y. pestis is categorized by the U.S...
  33. Rotator cuff repair using hyaluronan enriched fascia extracellular matrix
    KATHLEEN ANNE DERWIN; Fiscal Year: 2013
    ..dramatically reduce the incidence of debilitating pain, reduced shoulder function and weakness that chronically plague many elderly individuals, instead allowing them to maintain a healthy, active lifestyle in later years...
  34. Immunotherapeutics and vaccines against anthrax, plague and tularemia
    Zheng W Chen; Fiscal Year: 2010
    ..Both cellular and humoral immune responses may play a role in immunity to anthrax, plague and tularemia...
  35. The role of LPS-TLR4 signaling in live vaccine-induced protective responses
    Egil Lien; Fiscal Year: 2013
    ..The gram-negative bacterium Yersinia pestis is the causative agent of plague. Currently there is no available licensed plague vaccine, and exploratory vaccines have variable ability to ..
  36. Genetic and molecular basis of host resistance to Yersinia pestis.
    RICHARD IAN TAPPING; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of bubonic, septicemic and pneumonic plague and represents a serious bioterrorism threat. Most studies on Y...
  37. Eosinophils support nematode infection
    Judith A Appleton; Fiscal Year: 2012
    ..can be applied to the design of vaccines and therapies for diseases caused by parasitic worms that continue to plague people worldwide...
  38. Confocal Photacoustic Microscopy: Technology Development
    Lihong Wang; Fiscal Year: 2011
    ..Furthermore, PAM is free of speckle artifacts, which plague OCT and ultrasonography...
  39. ROLE OF YAPS IN Y. PESTIS PATHOGENESIS
    Virginia L Miller; Fiscal Year: 2010
    Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality. However, Y...
  40. Parasite Immunity Orchestrated by Th2 Cells
    Richard M Locksley; Fiscal Year: 2013
    ..RELEVANCE (See instructions): Parasitic helminth infections plague billions of persons worldwide and our understanding ofthe host immune response is only rudimentary...
  41. Small, noncoding RNAs and the evolution of Yersinia pestis virulence
    Wyndham W Lathem; Fiscal Year: 2013
    ..Yersinia pestis, responsible for the devastating disease plague, and Yersinia pseudotuberculosis, the causative agent of the mild, self-limiting disease Yersiniosis, are ..
  42. Sulfur stress in Salmonella enterica
    Lawrence J Reitzer; Fiscal Year: 2010
    ..since a particular enzyme that degrades cysteine is found in a variety of successful pathogens, such as the agents of cholera, bubonic plague, and tuberculosis, control of intracellular cysteine is important for bacterial virulence.
  43. The Olfactory Neural Circuit as a systems Level Model of Neurodegenerative Diseas
    MARK ALBERS; Fiscal Year: 2009
    DESCRIPTION (Provided by the applicant) Abstract: Neurodegenerative disease will increasingly plague our society as modern medicine augments the number of people reaching their seventh, eighth, and ninth decades...
  44. Development of Enabling Vector/Antigen Expression Technology for an Orally-Delive
    B Kim Lee Sim; Fiscal Year: 2013
    ..extended vaccination schedule (6 doses over 18 months) and has concerns over adverse effects;and 3) the lack of a plague vaccine licensed in the United States...
  45. Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia
    RUTH EILEEN SALO; Fiscal Year: 2012
    ..preferentially on the DA system and produces psychotic symptoms similar to SZ, may be the most damaging drug to plague this psychiatric population in decades...
  46. Improved plague vaccine by targeting dendritic cell subsets
    Yoonkyung Do; Fiscal Year: 2010
    b>Plague caused by the bacterium, Yersinia pestis (Y. pestis) remains an infectious disease of concern to public health due to the absence of a vaccine for humans and the isolation of antibiotic-resistant bacteria. Y...
  47. Attenuated Live and Recombinant Yersinia pestis Vaccines
    Roy Curtiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis, in three pandemics, resulted in some 200 million plague deaths and is still endemic throughout the world resulting in sporadic infections...
  48. A novel ternary virulence system in plague
    Susan C Straley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague in humans...
  49. Developing a Novel Plague Antibiotic by Targeting Protein Secretion
    Floyd E Romesberg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of plague, was the most deadly of all the bacterial pathogens in ancient and medieval times...
  50. Phage-mediated bioluminescent detection of Yersinia pestis
    David A Schofield; Fiscal Year: 2012
    ..Y. pestis is the etiological agent of the plague (Black Death), a transmissible disease that has been responsible for millions of deaths throughout the course of ..
  51. Determination of Skeletal Muscle Mass by Creatine Dilution
    Peggy Mannen Cawthon; Fiscal Year: 2013
    ..to problems with the existing tools for assessment of muscle mass: measurement error and/or feasibility issues plague existing techniques including 24-hour urinary excretion of creatinine;dual energy x- ray absorptiometry (DXA);..
  52. Ex vivo perfusion in a lung box for rehabilitation of donor lungs
    Victor E Laubach; Fiscal Year: 2013
    ..This project addresses two major problems that plague lung transplantation: far too few suitable lungs for transplant and primary graft failure after transplat due to ..
  53. Transplant Tolerance in Non-Human Primates
    STUART JOHNSTON KNECHTLE; Fiscal Year: 2013
    ..as stubborn adversaries as evidenced by the inexorable and stagnant graft and patient annual attrition rates that plague our patients...
  54. Bacteriolytic phage enzymes as novel antibacterials against Yersinia pestis
    Ian Molineux; Fiscal Year: 2009
    ..In particular, some isolates of Yersinia pestis, the causative agent of plague, are known to harbor multiple resistance determinants to commonly used antibiotics...
  55. MicroCal Auto-iTC200; automated high sensitivity isothermal titration calorimetry
    Christie G Brouillette; Fiscal Year: 2010
    ..titles for the four major users are given: NIAID U01 "Discovery and Preclinical Development of Drugs for Anthrax, Plague and Tularemia;" NIDCR R01 "Determination of the SAG Binding Motif on Agl/II of Streptococcous Mutans;" NCI P50 ..
  56. Regulation of host innate and adaptive immunity by bacterial type III effectors
    James B Bliska; Fiscal Year: 2013
    ..A T3SS that is critical for virulence in the bacterial pathogen Yersinia, which causes human diseases ranging from plague to gastroenteritis, is the focus of the project...
  57. Mechanisms of Phosphoryl Transfer
    Alvan C Hengge; Fiscal Year: 2010
    ..The PTP will be YopH, a virulence factor in the Yersinia bacteria responsible for Bubonic Plague, and the most efficient (highest kcat) phosphatase known...
  58. Water Soluble Antimitotics That Circumvent Rumor Resistance
    Susan L Mooberry; Fiscal Year: 2013
    ..and other antimitotics;3) are highly water soluble, thus overcome the lack of water solubility that continue to plague a large number of antimitotics including the newly approved ixabepilone;4) are selective for tumor cells over ..
  59. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague, a pandemic clinically divided into bubonic, septicemic, and pneumonic diseases...
  60. Development of TP-217 as a highly efficacious, broad-spectrum antibiotic for the
    ANNE KATHLEEN RADCLIFF; Fiscal Year: 2013
    ..Treatment and post-exposure prophylaxis against pneumonic plague - which is associated with up to 60% mortality - and CABP (such as methicillin-resistant Staphylococcus aureus) ..
  61. Oral Vaccine Platform for Yersinia pestis
    Lloyd F Mayer; Fiscal Year: 2012
    ..Demonstrate vaccine efficacy against mucosal challenge with Y. pestis using the mouse nasal model of pneumonic plague. PUBLIC HEALTH RELEVANCE: Vaccines provide the best defense against infectious diseases and biological warfare ..
  62. Yersiniabactin and plague pathogenesis
    ROBERT DONALD PERRY; Fiscal Year: 2013
    Yersinia pestis causes a zoonotic disease, plague, with well established reservoirs on every inhabited continent except Australia...
  63. Automating MRI Delta T1 Methods for the Routine Assessment of Brain Tumor Burden
    KATHLEEN MARIE SCHMAINDA; Fiscal Year: 2012
    ..challenges may explain the large inter-observer differences (greater than 50%) in assessing tumor burden that plague most clinical trials...
  64. Combinatorial vaccines against anthrax and plague
    John Clements; Fiscal Year: 2006
    ..immunization of civilian and military populations against potential bioterrorism agents, including anthrax and plague, Vaccines combining protective antigens from different microorganisms with potential for use against civilian or ..
  65. Inhaled Aminoglycoside Formulafor Plague and Tularemia
    James Talton; Fiscal Year: 2005
    ..for post-exposure treatment of aerosol exposure of the Category A bioterrorism agents pneumonic Yersina pestis (plague) and Francisella tularensis (tularemia)...
  66. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    Victims of bacterial bioterrorism agents such as anthrax, plague, and tularemia die very often because of septicemia and subsequent multiple organ dysfunction syndrome (MODS)...
  67. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2003
    Yersina pestis, the ethiologic agent of plague or Black Death, has in historical times caused devastating pandemics unrivaled by any other infectious disease...
  68. Phage-mediated bioluminescent detection of Yersinia pestis.
    David Schofield; Fiscal Year: 2009
    ..Y. pestis is the etiological agent of the plague (Black Death), a transmissible disease that has been responsible for millions of deaths throughout the course of ..
  69. Neurophysiological and Neuropharmacological Studies of a Parasitic Nematode
    Ralph Davis; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Parasitic nematodes plague the world as major contributors to disease, and anti-parasitic drugs (anthelmintics) are the primary control measure...
  70. Cambodia: Between the Khmers Rouges and the Red Plague?
    Patrick Heuveline; Fiscal Year: 2003
    ..The existence of this long-term observatory will complement and enhance future substantive research in this population. ..
  71. Mechanism of anti-phagocytosis by Yersinia pestis
    Kristiina Vuori; Fiscal Year: 2005
    Yersinia pestis, the causative agent of plague, is one of the most pathogenic bacteria known to mankind. Due to its high pathogenicity, Yersinia has been recognized as a potential weapon for bioterrorism...
  72. A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Yersinia pestis (Y. pestis), the causative agent of plague, is a Gram-negative bacillus that is classified as a Category A pathogen by the Centers for Disease Control and a logical choice ..
  73. Development, Production and Evaluation of a Multivalent Adenoviral Plague Vaccine
    CHRIS LENTZ; Fiscal Year: 2009
    ..adenoviral vaccine candidate that elicits a potent immune response against Yersinia pestis, the causative agent of plague. The proposed work is a collaborative effort between the University of Texas Medical Branch (UTMB), Norwell, Inc...
  74. RovA regulon of Yersinia pestis
    VIRGINIA MILLER; Fiscal Year: 2003
    Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality...
  75. HOST RANGE DIVERSITY OF BACTERIOPHAGE FOR Y. PESTIS
    David Martin; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Yersinia pestis, the bacterium responsible for plague, is a Category A pathogen, a significant biowarfare agent...
  76. Development of RSK Inhibitors as Novel Therapeutics for Yersinia pestis
    Jeffrey Smith; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of the plague, has been weaponized as an agent of biowarfare. The deliberate release of weaponized Y...