enterobacteriaceae infections

Summary

Summary: Infections with bacteria of the family ENTEROBACTERIACEAE.

Top Publications

  1. ncbi Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    Yan Zheng
    Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Med 14:282-9. 2008
  2. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
  3. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
  4. ncbi The CTX-M beta-lactamase pandemic
    Rafael Canton
    Servicio de Microbiologia, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Curr Opin Microbiol 9:466-75. 2006
  5. pmc Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa
    Kirk S B Bergstrom
    Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada
    PLoS Pathog 6:e1000902. 2010
  6. pmc CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
    Gregory F Sonnenberg
    Department of Microbiology and Institute for Immunology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 34:122-34. 2011
  7. pmc Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
    Chi Hye Park
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 50:3953-5. 2006
  8. ncbi Citrobacter rodentium of mice and man
    Rosanna Mundy
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London SW7 2AZ, UK
    Cell Microbiol 7:1697-706. 2005
  9. ncbi IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium
    Naruhisa Ota
    Department of Immunology, Genentech, South San Francisco, California, USA
    Nat Immunol 12:941-8. 2011
  10. ncbi Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis
    V S Conlin
    Division of Gastroenterology, Child and Family Research Institute, BC Children s Hospital, Vancouver, BC, Canada
    Am J Physiol Gastrointest Liver Physiol 297:G735-50. 2009

Detail Information

Publications268 found, 100 shown here

  1. ncbi Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    Yan Zheng
    Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Med 14:282-9. 2008
    ..rodentium infection. Together, our data identify a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens...
  2. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
    ..Thus, more rapid diagnostic testing of ESBL-producing bacteria and the possible modification of guidelines for community-onset bacteraemia associated with UTIs are required...
  3. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
    ..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
  4. ncbi The CTX-M beta-lactamase pandemic
    Rafael Canton
    Servicio de Microbiologia, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Curr Opin Microbiol 9:466-75. 2006
    ..All these events might have contributed to the current pandemic CTX-M beta-lactamase scenario...
  5. pmc Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa
    Kirk S B Bergstrom
    Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada
    PLoS Pathog 6:e1000902. 2010
    ..Such actions limit tissue damage and translocation of pathogenic and commensal bacteria across the epithelium...
  6. pmc CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
    Gregory F Sonnenberg
    Department of Microbiology and Institute for Immunology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 34:122-34. 2011
    ..Collectively these data demonstrate that adult CD4(+) LTi cells are a critical source of IL-22 and identify a previously unrecognized function for CD4(+) LTi cells in promoting innate immunity in the intestine...
  7. pmc Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
    Chi Hye Park
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 50:3953-5. 2006
    ..aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes...
  8. ncbi Citrobacter rodentium of mice and man
    Rosanna Mundy
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London SW7 2AZ, UK
    Cell Microbiol 7:1697-706. 2005
    ..Here we review the literature of C. rodentium from its emergence in the mid-1960s to the most contemporary reports of colonization, pathogenesis, transmission and immunity...
  9. ncbi IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium
    Naruhisa Ota
    Department of Immunology, Genentech, South San Francisco, California, USA
    Nat Immunol 12:941-8. 2011
    ..rodentium in mice lacking lymphotoxin signals, which suggests that IL-22 connects the lymphotoxin pathway to mucosal epithelial defense mechanisms...
  10. ncbi Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis
    V S Conlin
    Division of Gastroenterology, Child and Family Research Institute, BC Children s Hospital, Vancouver, BC, Canada
    Am J Physiol Gastrointest Liver Physiol 297:G735-50. 2009
    ..In conclusion, our results indicate that VIP protects the colonic epithelial barrier by minimizing bacterial-induced redistribution of tight junction proteins in part through actions on MLCK and MLC phosphorylation...
  11. ncbi Infections with extended-spectrum beta-lactamase-producing enterobacteriaceae: changing epidemiology and drug treatment choices
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada
    Drugs 70:313-33. 2010
    ....
  12. ncbi The efficacy of infection control interventions in reducing the incidence of extended-spectrum β-lactamase-producing Enterobacteriaceae in the nonoutbreak setting: A systematic review
    Shannon Goddard
    Department of Medicine, University of Toronto, Canada
    Am J Infect Control 39:599-601. 2011
    ..Although 4 uncontrolled, retrospective studies were included in the review, no well designed prospective studies capable of informing infection control practice were identified, underscoring the urgent need for research in this area...
  13. pmc AmpC beta-lactamases
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Clin Microbiol Rev 22:161-82, Table of Contents. 2009
    ....
  14. ncbi Real-time TaqMan PCR for rapid detection and typing of genes encoding CTX-M extended-spectrum beta-lactamases
    Christopher I Birkett
    Health Protection Agency, Clinical Microbiology and Public Health Laboratory, Addenbrooke s Hospital, Cambridge, UK
    J Med Microbiol 56:52-5. 2007
    ..The new TaqMan assay detected and typed bla(CTX-M) genes in 21 of 28 ESBL-producing isolates...
  15. pmc How to detect NDM-1 producers
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    J Clin Microbiol 49:718-21. 2011
    ..Colonies growing on these screening media can be verified as NDM-1 producers with molecular methods as described herein...
  16. ncbi A multinational survey of risk factors for infection with extended-spectrum beta-lactamase-producing enterobacteriaceae in nonhospitalized patients
    Ronen Ben-Ami
    Infectious Diseases Unit and the 2Division of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel
    Clin Infect Dis 49:682-90. 2009
    ..Circulation of CTX-M-type ESBLs in the community is of particular concern, because it may confound standard infection-control measures...
  17. ncbi Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 60:913-20. 2007
    ..We performed a systematic review and meta-analysis to examine the impact of extended-spectrum beta-lactamase (ESBL) production on mortality and delay in effective therapy in Enterobacteriaceae bacteraemia...
  18. ncbi Extended-spectrum beta-lactamase-producing organisms
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    J Hosp Infect 73:345-54. 2009
    ..Tigecycline and polymyxins have substantial antimicrobial activity against ESBL-producing Enterobacteriaceae, and, along with fosfomycin, merit further evaluation...
  19. ncbi Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Infect Dis 201:81-91. 2010
    ..Therefore, the aims of this study were to characterize Citrobacter rodentium infection in neonatal mice and determine the role played by specific probiotics in ameliorating disease severity...
  20. pmc High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals
    Junying Ma
    College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues, South China Agricultural University, Guangzhou
    Antimicrob Agents Chemother 53:519-24. 2009
    ..PMQR determinants are highly prevalent in ceftiofur-resistant Enterobacteriaceae strains isolated from animals in China. This is the first report of the occurrence of PMQR determinants among isolates from companion animals...
  21. ncbi Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe
    R Canton
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Clin Microbiol Infect 14:144-53. 2008
    ....
  22. ncbi Attaching and effacing pathogen-induced tight junction disruption in vivo
    Julian A Guttman
    The University of British Columbia, Michael Smith Laboratories, 301 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
    Cell Microbiol 8:634-45. 2006
    ..These results suggest that the diarrhoea induced by A/E pathogens occurs as part of functional tight junction disruption...
  23. ncbi Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression
    S Ghosh
    Department of Biology, University of British Columbia Okanagan, Kelowna, Canada
    Am J Physiol Gastrointest Liver Physiol 301:G39-49. 2011
    ..This study reveals that the microbiota is sufficient to overcome inherent genetic susceptibility patterns in C3H/HeOuJ mice that cause mortality during C. rodentium infection...
  24. ncbi TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium
    Sarah L Lebeis
    Microbiology and Molecular Genetics Graduate Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 165 Michael Street, Atlanta, GA 30322, USA
    J Immunol 179:566-77. 2007
    ..Taken together, these experiments provide evidence for a protective role of innate immune signaling in infections caused by attaching and effacing pathogens...
  25. pmc Carbapenemases: the versatile beta-lactamases
    Anne Marie Queenan
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Clin Microbiol Rev 20:440-58, table of contents. 2007
    ..This review updates the characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria...
  26. pmc Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species
    Eva Kucerova
    School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom
    PLoS ONE 5:e9556. 2010
    ..The most severe diseases are caused in neonates and include fatal necrotizing enterocolitis and meningitis. The genetic basis of the diversity within the genus is unknown, and few virulence traits have been identified...
  27. pmc Escherichia albertii in wild and domestic birds
    J Lindsay Oaks
    Washington Animal Disease Diagnostic Laboratory, Washington State University, PO Box 647034, Pullman, WA 99164 7034, USA
    Emerg Infect Dis 16:638-46. 2010
    ..Genetic analysis of eae and cdtB sequences, multilocus sequence typing, and pulsed-field gel electrophoresis patterns showed that the E. albertii strains from birds are heterogeneous but similar to isolates that cause disease in humans...
  28. ncbi Characterization and molecular epidemiology of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in a Tunisian University Hospital
    Safia Dahmen
    Infections with multiresistant bacteria to antibiotics UR 29 04, Department of Microbiology, University Hospital of Sahloul, Sousse, Tunisia
    Microb Drug Resist 16:163-70. 2010
    ..This study confirms the high rate of ESBLs in Tunisia and further demonstrates the worldwide spread of genes coding for CTX-M-15 enzymes in clinical isolates...
  29. ncbi The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    J Immunol 183:6579-87. 2009
    ..Our results provide further evidence for functional heterogeneity in intestinal NKp46(+) cells that contrast with splenic NK cells...
  30. pmc EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics
    Sivan Dahan
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 73:679-86. 2005
    ....
  31. ncbi Control of Enterobacteriaceae producing extended-spectrum beta-lactamase in intensive care units: rectal screening may not be needed in non-epidemic situations
    Michelle Thouverez
    Service d Hygiène Hospitalière et d Épidémiologie Moléculaire, CHU Jean Minjoz, Besancon Cedex, France
    Infect Control Hosp Epidemiol 25:838-41. 2004
    ..To evaluate the usefulness of screening cultures in the control of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in intensive care units (ICUs)...
  32. pmc Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions
    Eytan Wine
    Pediatric Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 177:1320-32. 2010
    ..rodentium infection, indicating that OPN impacts disease pathogenesis through bacterial attachment and altered host immune responses...
  33. pmc Female Drosophila melanogaster suffer reduced defense against infection due to seminal fluid components
    Sarah M Short
    Field of Genetics and Development, Cornell University Ithaca, NY 14853, USA
    J Insect Physiol 58:1192-201. 2012
    ....
  34. ncbi Rate of transmission of extended-spectrum beta-lactamase-producing enterobacteriaceae without contact isolation
    Sarah Tschudin-Sutter
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland
    Clin Infect Dis 55:1505-11. 2012
    ..Therefore, we aimed to estimate the rate of spread (R(0)) of ESBL-producing Enterobacteriaceae in a tertiary care center with 5 intensive care units...
  35. pmc Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-κB and p38 mitogen-activated protein kinase activation
    Ho Pan Sham
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia, Canada V6H 3V4
    Infect Immun 79:3552-62. 2011
    ..rodentium in a cecal loop model induced significantly greater chemokine responses than infection with wild-type bacteria. These studies thus advance our understanding of how A/E pathogens subvert host inflammatory responses...
  36. pmc CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium
    C Manta
    Department of Internal Medicine I, University of Ulm, Ulm, Germany
    Mucosal Immunol 6:177-88. 2013
    ..The depletion of CX(3)CR1(+) cells by diphtheria toxin injection in CX(3)CR1-GFP × CD11c.DOG animals confirmed the role of CX(3)CR1(+) phagocytes in establishing IL-22 production, supporting the clearance of a C. rodentium infection...
  37. pmc Molecular epidemiology of the integron-located VEB-1 extended-spectrum beta-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand
    D Girlich
    , , , , , France
    J Clin Microbiol 39:175-82. 2001
    ..Plasmid- and integron-mediated resistance to rifampin was also found in enterobacterial isolates...
  38. pmc The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
    Lucille C Rankin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Nat Immunol 14:389-95. 2013
    ..Our results pinpoint the regulation of Notch signaling by T-bet as a distinct molecular pathway that guides the development of NKp46+ ILCs...
  39. ncbi Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: subunit vaccine vs DNA vaccine
    Yun Sun
    Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, PR China Graduate University of the Chinese Academy of Sciences, Beijing 100049, PR China
    Vaccine 29:2051-7. 2011
    ..Taken together, these results indicate that both rEta2 and pCEta2 induce specific and nonspecific immunities, however, pCEta2 induces both B cell and T cell responses, whereas rEta2 induces mainly humoral response...
  40. pmc Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda
    Joost J van Soest
    Institute of Biology, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    BMC Immunol 12:58. 2011
    ..In this study we used transcriptome profiling and quantitative RT-PCR to analyze the immune response induced by E. tarda immersion and injection...
  41. ncbi Is surveillance for multidrug-resistant enterobacteriaceae an effective infection control strategy in the absence of an outbreak?
    Michael A Gardam
    Infection Prevention and Control Unit, Toronto General Hospital, Toronto, Ontario, Canada M5G 2C4
    J Infect Dis 186:1754-60. 2002
    ..The annual cost of a surveillance program was calculated at Canadian $1,130,184.44. Thus, the routine and costly use of MDRE surveillance and isolation precautions are not warranted in the absence of a clonal outbreak in this population...
  42. ncbi Distribution of cotrimoxazole resistance genes associated with class 1 integrons in clinical isolates of Enterobacteriaceae in a university hospital in Tunisia
    Safia Dahmen
    Infections with multiresistant bacteria to antibiotics UR 29 04, Department of Microbiology, University Hospital of Sahloul, Sousse, Tunisia
    Microb Drug Resist 16:43-7. 2010
    ..The types, combinations, and frequency of the gene cassettes in integrons provide useful data for the surveillance of antimicrobial resistance in our hospital and for the prescription practice of cotrimoxazole...
  43. ncbi Clinical epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae
    Nimish Patel
    Pharmacy Practice Department, Albany College of Pharmacy and Health Sciences, Albany, NY 12208 3492, USA
    J Antimicrob Chemother 66:1600-8. 2011
    ..This study characterizes factors associated with CIRE among two different source populations...
  44. ncbi Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics
    Kathene C Johnson-Henry
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 191:2106-17. 2005
    ..We sought to determine whether pretreatment of mice with a mixture of Lactobacillus rhamnosus and L. acidophilus probiotics would attenuate C. rodentium-induced colonic disease in mice...
  45. ncbi Identification and screening of carbapenemase-producing Enterobacteriaceae
    P Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Clin Microbiol Infect 18:432-8. 2012
    ..Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media...
  46. pmc Proportion of extended-spectrum ß-lactamase-producing Enterobacteriaceae in community setting in Ngaoundere, Cameroon
    Carine Magoué Lonchel
    Laboratory of Medical Microbiology, University of Liege, CHU Sart Tilman B23, B 4000 Liege, Belgium
    BMC Infect Dis 12:53. 2012
    ..The current study aimed to determine the proportion of ESBLs in Enterobacteriaceae isolated in the community and to analyse some risk factors associated with ESBL carriage...
  47. pmc IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens
    Sara M Dann
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 180:6816-26. 2008
    ..Thus, IL-6 is an important regulator of host defense against C. rodentium by protecting the mucosa against ulcerations which can act as a microbial niche for the bacteria...
  48. ncbi Massive increase, spread, and exchange of extended spectrum β-lactamase-encoding genes among intestinal Enterobacteriaceae in hospitalized children with severe acute malnutrition in Niger
    Paul Louis Woerther
    French National Reference Center for Bacterial Resistance in Commensal Flora, Laboratory of Bacteriology, Bichat Claude Bernard Hospital, Assistance Publique Hopitaux de Paris
    Clin Infect Dis 53:677-85. 2011
    ..Although their dissemination appears linked to Escherichia coli intestinal carriage, precise paths of this dynamic are largely unknown...
  49. pmc CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen
    Martina E Spehlmann
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 183:3332-43. 2009
    ..Thus, CXCR2-dependent processes, particularly mucosal neutrophil influx, not only contribute to host defense against C. rodentium, but provide protection against infection-associated diarrhea...
  50. pmc Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge
    Alexei V Tumanov
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 10:44-53. 2011
    ..Taken together, our data show that LTβR signaling in gut lymphoid follicles regulates IL-22 production by ILCs in response to mucosal pathogen challenge...
  51. pmc Involvement of T helper type 17 and regulatory T cell activity in Citrobacter rodentium invasion and inflammatory damage
    E L Symonds
    Alimentary Pharmabiotic Centre, NUI Cork, Ireland
    Clin Exp Immunol 157:148-54. 2009
    ..These changes may play a role in the pathology and clearance of C. rodentium...
  52. ncbi A sensitive and specific phenotypic assay for detection of metallo-β-lactamases and KPC in Klebsiella pneumoniae with the use of meropenem disks supplemented with aminophenylboronic acid, dipicolinic acid and cloxacillin
    C G Giske
    Clinical Microbiology, MTC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Clin Microbiol Infect 17:552-6. 2011
    ..The commercial combination tablets from Rosco performed similarly to the in-house test, with the exception of one false-positive MBL result and one false-positive KPC result among the OXA-48 producers...
  53. ncbi Construction and evaluation of DNA vaccines encoding Edwardsiella tarda antigens
    Xu dong Jiao
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Vaccine 27:5195-202. 2009
    ..Furthermore, the induction magnitudes of most of these genes were significantly higher in pCE6-vaccinated fish than in pEta6-vaccinated fish...
  54. ncbi Utility of the Citrobacter rodentium infection model in laboratory mice
    Diana Borenshtein
    Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Curr Opin Gastroenterol 24:32-7. 2008
    ..Given the difficulty of infecting laboratory mice with these diarrhea-causing pathogens, a growing number of studies have found the murine bacterial pathogen Citrobacter rodentium to provide a robust, relevant in-vivo model system...
  55. ncbi From bench to bedside: stealth of enteroinvasive pathogens
    Renee M Tsolis
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, 95616 California, USA
    Nat Rev Microbiol 6:883-92. 2008
    ..Host responses contribute to the clinical presentation of disease and improved understanding of these responses in the laboratory is beginning to bridge the gap between bench and bedside...
  56. ncbi Prospective evaluation of colonization with extended-spectrum beta-lactamase (ESBL)-producing enterobacteriaceae among patients at hospital admission and of subsequent colonization with ESBL-producing enterobacteriaceae among patients during hospitalizati
    Reuven Friedmann
    Department of Geriatrics, Shaare Zedek Medical Center, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Infect Control Hosp Epidemiol 30:534-42. 2009
    ..To determine the rates of and risk factors for carriage and acquisition of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae during hospitalization...
  57. pmc Neonatal enteral feeding tubes as loci for colonisation by members of the Enterobacteriaceae
    Edward Hurrell
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
    BMC Infect Dis 9:146. 2009
    ..Enterobacter sakazakii) and other Enterobacteriaceae, and whether their presence was influenced by the feeding regime...
  58. ncbi Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens
    Mitsutoshi Iimura
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0623, USA
    J Immunol 174:4901-7. 2005
    ..Moreover, Cnlp+/+ mice were protected from oral infections with C. rodentium inocula that infected the majority of Cnlp-/- mice. These results establish cathelicidin as an important component of innate antimicrobial defense in the colon...
  59. ncbi Occurrence and characterization of carbapenemase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program (2000-2004)
    Lalitagauri M Deshpande
    JMI Laboratories, North Liberty, Iowa, USA
    Microb Drug Resist 12:223-30. 2006
    ....
  60. pmc Spread of OXA-48-encoding plasmid in Turkey and beyond
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 54:1369-73. 2010
    ..That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide...
  61. pmc Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection
    Yugang Wang
    The University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Immunity 32:403-13. 2010
    ..These results support a model wherein LT from RORgammat(+) cells orchestrates the innate immune response against mucosal microbial infection...
  62. pmc Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies
    Christian Maaser
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 72:3315-24. 2004
    ..These results indicate that host defense against C. rodentium depends on B cells and IgG antibodies but does not require production or transepithelial transport of IgA or secreted IgM...
  63. ncbi Therapeutic options for infections with Enterobacteriaceae producing carbapenem-hydrolyzing enzymes
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Future Microbiol 6:653-66. 2011
    ..Combination antimicrobial therapy with agents exhibiting synergy might also be of benefit, until novel effective agents could become clinically available...
  64. ncbi Edwardsiellosis in fish: a brief review
    B R Mohanty
    Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar 751 002, India
    J Biosci 32:1331-44. 2007
    ..This article briefly discusses some of the recent research on edwardsiellosis, describing the pathogen's interaction with the host and environment, its pathogenesis and pathology as well as diagnostic, preventive and control measures...
  65. pmc Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen
    Kirk S B Bergstrom
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia, Canada
    Infect Immun 76:796-811. 2008
    ....
  66. ncbi Characterization of sulphonamide resistance genes and class 1 integron gene cassettes in Enterobacteriaceae, Central African Republic (CAR)
    Thierry Frank
    Institut Pasteur de Bangui, Bangui, Central African Republic
    J Antimicrob Chemother 59:742-5. 2007
    ....
  67. pmc Isolation of imipenem-resistant Enterobacter species: emergence of KPC-2 carbapenemase, molecular characterization, epidemiology, and outcomes
    Dror Marchaim
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 52:1413-8. 2008
    ..IRE infections are associated with increased mortality. Enhanced measures to control the hospital spread of IRE are warranted...
  68. ncbi Dissemination of a bla(VIM-2)-carrying integron among Enterobacteriaceae species in Mexico: report from the SENTRY Antimicrobial Surveillance Program
    Rayo Morfin-Otero
    Instituto de Pathologia Infecciosa y Experimental, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico
    Microb Drug Resist 15:33-5. 2009
    ..The interspecies dissemination of this bla(VIM-2)-harboring element emphasizes the potential for spread of genetic structures carrying metallo-beta-lactamases that could limit therapeutic options in this geographic region...
  69. pmc Molecular dissection of an outbreak of carbapenem-resistant enterobacteriaceae reveals Intergenus KPC carbapenemase transmission through a promiscuous plasmid
    Amy J Mathers
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    MBio 2:e00204-11. 2011
    ..Whether infection control measures that focus on preventing transmission of drug-resistant clones are effective in controlling dissemination of these elements is unknown...
  70. ncbi Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo
    J H Sellin
    Department of Internal Medicine, The University of Texas Medical School-Houston, 77030, USA
    Cancer Res 61:2899-906. 2001
    ..These findings predict that an oncogenic signaling mechanism related to non-E-cadherin-bound beta-catenin is active in hyperproliferating native colonocytes and is similar to that recorded during the early stages of colon carcinogenesis...
  71. ncbi Probiotics are effective for the prevention and treatment of Citrobacter rodentium-induced colitis in mice
    David M Rodrigues
    Research Institute, Hospital for Sick Children, University of Toronto, Canada
    J Infect Dis 206:99-109. 2012
    ..Probiotics prevent disease induced by Citrobacter rodentium, a murine-specific enteric pathogen. Whether probiotics can be used to interrupt the infectious process following initiation of infection was determined...
  72. ncbi Fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in Korean community and hospital settings
    Y J Ko
    Department of Laboratory Medicine, Konkuk University School of Medicine, Konkuk University Hospital, 4 12, Hwayang dong, Seoul, 143 729, Korea
    Infection 41:9-13. 2013
    ..The aim of the present study was to investigate the prevalence of fecal carriage of ESBL-E in healthy individuals and hospitalized high-risk patients in Korea and to compare the characteristics of ESBL-E in these two groups...
  73. ncbi TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation
    Lisa A Mielke
    Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    J Immunol 191:4383-91. 2013
    ..Collectively, our findings demonstrate an essential requirement for TCF-1 in ILC2 differentiation and reveal a link among Tcf7, Notch, and Tbx21 in NKp46(+) ILC3 development. ..
  74. pmc Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38
    Parthasarathy Chandrakesan
    Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 285:33485-98. 2010
    ..The MEK/ERK/p38 pathway therefore seems to modulate sustained activation of NF-κB in colonic crypts in response to C. rodentium infection...
  75. pmc Countrywide spread of community- and hospital-acquired extended-spectrum beta-lactamase (CTX-M-15)-producing Enterobacteriaceae in Lebanon
    Carole Moubareck
    Laboratoire de Microbiologie, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris 5 Rene Descartes, Paris, France
    J Clin Microbiol 43:3309-13. 2005
    ..In addition to the fact that the present study highlights the emergence and the countrywide dissemination of CTX-M-15-producing E. coli in Lebanon, it represents the first report of an SHV-5a-producing C. freundii...
  76. ncbi Preinoculation with the probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colitis
    Chien Chang Chen
    Chang Gung Children s Hospital and Chang Gung University, Taoyuan, Taiwan
    Pediatr Res 58:1185-91. 2005
    ..This study may have ramifications for prevention of infectious diarrhea in human infants and children, particularly in developing countries...
  77. ncbi Urinary tract infection trends in Latin American hospitals: report from the SENTRY antimicrobial surveillance program (1997-2000)
    Ana C Gales
    Division of Infectious Diseases, Universidade Federal de, Sao Paulo, SP, Brazil
    Diagn Microbiol Infect Dis 44:289-99. 2002
    ..Carbapenem-resistant P. aeruginosa, ciprofloxacin-resistant E. coli, ESBL-producing K. pneumoniae constitute serious problem in this geographic region...
  78. pmc GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen
    Yoshihiro Hirata
    Department of Medicine, University of California, San Diego, La Jolla, 92093 0623, USA
    Cell Host Microbe 7:151-63. 2010
    ..Thus, GM-CSF produced in the intestinal mucosa acts to enhance host protection against an enteric bacterial pathogen through regulating recruitment and survival of DCs...
  79. ncbi Surveillance of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in a Swiss Tertiary Care Hospital
    C Fankhauser
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Swiss Med Wkly 139:747-51. 2009
    ....
  80. ncbi Determining incidence of extended spectrum beta-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001-2002
    S K Bouchillon
    Laboratories International for Microbiology Studies, 2122 Palmer Road, Schaumburg, IL 60173 3817, USA
    Int J Antimicrob Agents 24:119-24. 2004
    ..4% (294/908) and 8.7% (83/949), respectively. PEARLS provides baseline data against which prospective changes in resistant determinants and outcomes can be measured in this ongoing study...
  81. ncbi Ertapenem-resistant Enterobacteriaceae: risk factors for acquisition and outcomes
    E P Hyle
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114 2696, USA
    Infect Control Hosp Epidemiol 31:1242-9. 2010
    ..We sought to determine risk factors for acquisition of ertapenem-resistant, meropenem-susceptible, or intermediate Enterobacteriaceae and to assess associated patient outcomes...
  82. pmc Prevalence of fecal carriage of acquired expanded-spectrum cephalosporin resistance in Enterobacteriaceae strains from cattle in France
    Jean Yves Madec
    J Clin Microbiol 46:1566-7. 2008
  83. ncbi Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay
    Spyros Pournaras
    Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece
    Int J Antimicrob Agents 37:244-7. 2011
    ..Additional in vivo tests are warranted to assess better the killing kinetics of tigecycline combinations against KPC-producers...
  84. ncbi Unnoticed spread of integron-carrying Enterobacteriaceae in intensive care units
    S Nijssen
    Division of Acute Medicine and Infectious Diseases, University Medical Center Utrecht, The Netherlands
    Clin Infect Dis 41:1-9. 2005
    ..The prevalence of integrons and the incidence of cross-transmission and horizontal gene transfer in Enterobacteriaceae with reduced susceptibility to cephalosporins (ERSC) were determined for 2 intensive care units (ICUs)...
  85. ncbi Control of a prolonged outbreak of extended-spectrum beta-lactamase-producing enterobacteriaceae in a university hospital
    J C Lucet
    Unité d hygiène et de lutte contre l infection nosocomiale, Group Hospitalier Bichat Claude Bernard, Paris, France jean christophe
    Clin Infect Dis 29:1411-8. 1999
    ..The outbreak was effectively controlled without restricting antimicrobial use...
  86. ncbi Prevalence of and risk factors associated with faecal carriage of CTX-M β-lactamase-producing Enterobacteriaceae in rural Thai communities
    Ulzii Orshikh Luvsansharav
    Department of Bioinformatics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Antimicrob Chemother 67:1769-74. 2012
    ..To determine the prevalence of CTX-M β-lactamase-producing Enterobacteriaceae and to study the risk factors associated with faecal carriage in asymptomatic rural Thai people...
  87. ncbi Extended-spectrum beta-lactamases and the permeability barrier
    L Martinez-Martinez
    Service of Microbiology, University Hospital Marques de Valdecilla, Santander, Spain
    Clin Microbiol Infect 14:82-9. 2008
    ..Porin loss also decreases the susceptibility to other non-beta-lactam compounds, such as fluoroquinolones, of ESBL-producing organisms...
  88. pmc Genetic loci of major antigenic protein genes of Edwardsiella tarda
    Noel Verjan
    Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4 5 7 Konan, Minato, Tokyo 108 8477, Japan
    Appl Environ Microbiol 71:5654-8. 2005
    ..These genes and their products are useful for developing DNA or recombinant subunit vaccines to control edwardsiellosis...
  89. ncbi Characterization of Edwardsiella tarda strains isolated from turbot, Psetta maxima (L.)
    N Castro
    Departamento de Microbiologia y Parasitologia, Facultad de Biología e Instituto de Acuicultura, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    J Fish Dis 29:541-7. 2006
    ..tarda strains from turbot were compiled in a unique group using the primers P3 and P6, two clonal lineages could be detected when oligonucleotides P4 and P5 were employed...
  90. ncbi Disparity in infection control practices for multidrug-resistant Enterobacteriaceae
    Christopher Lowe
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Am J Infect Control 40:836-9. 2012
    ..In this context, we expect that infection control practices for these organisms vary widely between hospitals...
  91. ncbi Analysis of the vaccine potential of a natural avirulent Edwardsiella tarda isolate
    Shuang Cheng
    Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, PR China
    Vaccine 28:2716-21. 2010
    ..These results indicated that ATCC 15947 possesses good immunoprotective potential, which may be exploited in the development of E. tarda vaccines...
  92. ncbi Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance in carbapenem-resistant Enterobacter cloacae in China
    Qiong Wu
    Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People s Republic of China
    Diagn Microbiol Infect Dis 66:326-8. 2010
    ..bla(KPC-2) was located on a large nonconjugative plasmid, whereas armA was located on another conjugative plasmid. Although carbapenem-resistant Enterobacteriaceae remains rare, the emergence of this group of organism merits monitoring...
  93. pmc Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo
    Valerie F Crepin
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK
    Mol Microbiol 75:308-23. 2010
    ..Importantly, wild-type C. rodentium out-competed the tir tyrosine mutants during mixed infections. These results uncouple the Tir:Nck and Tir:IRTKS pathways from A/E lesion formation in vivo but assign them an important in vivo role...
  94. ncbi Dissemination of the CTX-M-25 family beta-lactamases among Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae and identification of the novel enzyme CTX-M-41 in Proteus mirabilis in Israel
    Shiri Navon-Venezia
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Antimicrob Chemother 62:289-95. 2008
    ..We aimed to describe the occurrence and to understand the dissemination of this extended-spectrum beta-lactamase family among Enterobacteriaceae strains in our hospital...
  95. pmc First descriptions of blaKPC in Raoultella spp. (R. planticola and R. ornithinolytica): report from the SENTRY Antimicrobial Surveillance Program
    Mariana Castanheira
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 47:4129-30. 2009
    ..All patients had received previous antimicrobial treatment, including carbapenems. These strains harbored bla(KPC-2) and bla(KPC-3). Carbapenemase genes were embedded in isoforms of Tn4401 and were plasmidic and chromosomal in location...
  96. ncbi New Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised
    Payal Deshpande
    Dept of Research, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India
    J Assoc Physicians India 58:147-9. 2010
    ..Many of them were recently hospitalized in India and Pakistan and had new type of metallo beta lactamase designated as New Delhi Metallo-1 (NDM-1)...
  97. ncbi Protection of tilapia (Oreochromis mosambicus) from edwardsiellosis by vaccination with Edwardsiella tarda ghosts
    Se Ryun Kwon
    Department of Aquatic Life Medicine, Pukyong National University, Pusan 608 737, Republic of Korea
    Fish Shellfish Immunol 20:621-6. 2006
    ..As this promising type of a non-living whole cell envelope preparation seems to be favorable over conventional vaccines, we suggest E. tarda ghosts as a new vaccine candidate...
  98. ncbi Molecular diagnosis of Raoultella planticola infection of a surgical site
    R Wolcott
    Southwest Regional Wound Care Center, Lubbock, Texas, USA
    J Wound Care 19:329-32. 2010
    ..This pathogen was diagnosed with rapid clinical molecular pathogen diagnostic methods, which allowed an appropriate therapy to be implemented, thereby improving prognosis...
  99. ncbi Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia
    S A Luperchio
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56-787B, Cambridge, Massachusetts 02139, USA
    Microbes Infect 3:333-40. 2001
    ..C. rodentium serves as an important model pathogen for investigating the mechanisms controlling attaching and effacing pathology, epithelial hyperproliferation, and tumor promotion in the distal colon of the mouse...
  100. ncbi A case of severe pancreatitis complicated by Raoultella planticola infection
    M S Alves
    Departamento de Analises Clinicas, Universidade Federal de Juiz de Fora, Campus Universitario, Bairro Martelos, Juiz de Fora, MG 36036 330, Brazil
    J Med Microbiol 56:696-8. 2007
    ..R. planticola is difficult to identify in the clinical laboratory, and the clinical significance of this isolation remains uncharacterized. This is the first report of pancreatitis with a primary infection by R. planticola...
  101. ncbi Spread of plasmids containing the bla(VIM-1) and bla(CTX-M) genes and the qnr determinant in Enterobacter cloacae, Klebsiella pneumoniae and Klebsiella oxytoca isolates
    Elisenda Miro
    Servei de Microbiologia, Hospital de Sant Pau, Barcelona, Spain
    J Antimicrob Chemother 65:661-5. 2010
    ....

Research Grants34

  1. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle M Zerr; Fiscal Year: 2013
    ..3. To define the demographic, clinical, and bacterial factors associated with PBLR in Enterobacteriaceae infections in pediatric patients. Methods. A consortium of 4 pediatric hospitals is involved in this project...
  2. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle Zerr; Fiscal Year: 2009
    ..3. To define the demographic, clinical, and bacterial factors associated with PBLR in Enterobacteriaceae infections in pediatric patients. Methods. A consortium of 4 pediatric hospitals is involved in this project...
  3. Genetic Analysis of Zebrafish Biliary Mutants
    Randolph Matthews; Fiscal Year: 2008
    ..These studies in zebrafish may provide clues as to biliary development in mammals and to genetic contributions to cholestatic diseases in humans [unreadable] [unreadable]..
  4. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard L Guerrant; Fiscal Year: 2010
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
  5. beta-Catenin/NF-kappaBeta and Colon Cancer
    Shahid Umar; Fiscal Year: 2004
    ..By studying a mechanistic basis of NF-kappaB and beta-catenin mediated increases in cell census, in the absence and presence of chronic inflammation, we may identify new treatment strategies for reducing cancer risk. ..
  6. MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASE
    Lars Eckmann; Fiscal Year: 2010
    ..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
  7. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  8. HHV-6 and CNS disease following stem cell transplant
    Danielle Zerr; Fiscal Year: 2009
    ..Data from this project will not only inform current diagnosis of and prognosis for HHV-6 CNS dysfunction, but will also be used to design an intervention trial. ..
  9. Pathogen of Enterotoxigenic Bacteriodes Fragilis Infect
    CYNTHIA SEARS; Fiscal Year: 2003
    ..We hypothesize that ETBF is an under-recognized intestinal pathogen accounting for a portion of previously undiagnosed inflammatory intestinal infections in both children and adults. ..
  10. DEFINING PRIMARY HHV-6 AND HHV7 INFECTIONS IN CHILDREN
    Danielle Zerr; Fiscal Year: 2003
    ..These studies will also give me the opportunity to develop the required skills to perform clinical research and to reach my long term goal; to become an independent investigator in an academic institution. ..
  11. EXPERIMENTAL PATHOLOGY SHARED RESOURCE LABORATORY
    Laura Lamps; Fiscal Year: 2003
    ..abstract_text> ..
  12. HOST DEFENSES AGAINST PATHOGENIC E. coli
    Lars Eckmann; Fiscal Year: 2007
    ..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
  13. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    ..Our studies may indicate that a common stool bacterium is oncogenic and contributes to colon cancer risk. If so, these data will lead to new public health approaches to the prevention of colon cancer. ..
  14. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  15. A randomized trial of influenza vaccination of Hutterite children
    Mark Loeb; Fiscal Year: 2006
    ..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
  16. Clinical Research and Mentoring in Infectious Disease
    Kent Sepkowitz; Fiscal Year: 2006
    ..abstract_text> ..
  17. THE ROLE OF MAST CELL STAT6 IN TH2 DIFFERENTIATION
    Melanie Sherman; Fiscal Year: 2004
    ....
  18. Protective role of cross-reactive anti-enteric antibody
    Lynn Bry; Fiscal Year: 2005
    ....
  19. EHEC interactions with the normal intestinal flora
    Vanessa Sperandio; Fiscal Year: 2004
    ..In Specific Aim 2, we propose to monitor EHEC virulence gene expression in a mixed population in the presence of the intestinal flora. ..
  20. Screen for Quorum Sensing Molecular Inhibitors (RMI)
    Vanessa Sperandio; Fiscal Year: 2005
    ....
  21. NEUROENDOCRINE MEDIATION OF E. COLI 0157:H7 INFECTION
    Mark Lyte; Fiscal Year: 2003
    ..The demonstration of direct neuroendocrine-bacterial interaction as a mechanism in the pathogenesis of E. coli O157:H7 infection may yield new treatments for both the prevention and treatment of hemorrhagic colitis. ..
  22. Reducing Antimicrobial Use Associated with Ventilator Associated Pneumonia and Ca
    SARA ELIZABETH COSGROVE; Fiscal Year: 2010
    ..We hypothesize that this approach will enhance appropriate use of antimicrobials for both VAP and CAUTI and improve patient outcomes by reducing the known sequelae of antimicrobial overuse. ..
  23. Crimson - i2b2 integration for high-throughput, scalable sample collection
    Lynn Bry; Fiscal Year: 2010
    ....
  24. DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUES
    JEANNE JORDAN; Fiscal Year: 2003
    ....
  25. Gut to Brain Pathways for Infection-Induced Anxiety
    Mark Lyte; Fiscal Year: 2005
    ..abstract_text> ..
  26. EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODE
    David Nix; Fiscal Year: 2009
    ..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
  27. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2009
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
  28. Impact of Social Stress on TLR4-Induced Microbicidal Activity of CD11b+ Cells
    Michael Bailey; Fiscal Year: 2008
    ..Defining the stress-induced cellular changes that enhance immune functioning could stimulate new therapeutic approaches to treating infectious diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATION
    Lars Eckmann; Fiscal Year: 2008
    ..abstract_text> ..
  30. Role of T cells in self-limited mucosal infections
    Lynn Bry; Fiscal Year: 2006
    ..This training provides a necessary step in the candidate's goal to become an independent researcher investigating questions in mucosal immunology and host-microbial cross-talk in intestinal environments. ..
  31. MOLECULAR MECHANISMS OF EIAV PERSISTENCE
    JERALD OAKS; Fiscal Year: 2001
    ..These studies will provide insight into HIV persistence in HAART patients, and potentially provide a model that can be used to evaluate strategies for actual elimination of lentiviral infections. ..
  32. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  33. DIFERENTIAL ACTIVATION OF THE VITAMIN D RECEPTOR
    Sara Peleg; Fiscal Year: 2003
    ..These studies will facilitate the development of selective vitamin D receptor modulators that may be useful for treatment of various clinical conditions, including osteoporosis, secondary hyperparathyroidism, and cancer. ..