enterobacteriaceae infections

Summary

Summary: Infections with bacteria of the family ENTEROBACTERIACEAE.

Top Publications

  1. doi Citrobacter infections in a general hospital: characteristics and outcomes
    G Samonis
    Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Greece
    Eur J Clin Microbiol Infect Dis 28:61-8. 2009
  2. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
  3. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
  4. ncbi The CTX-M beta-lactamase pandemic
    Rafael Canton
    Servicio de Microbiologia, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Curr Opin Microbiol 9:466-75. 2006
  5. doi Infections with extended-spectrum beta-lactamase-producing enterobacteriaceae: changing epidemiology and drug treatment choices
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada
    Drugs 70:313-33. 2010
  6. pmc AmpC beta-lactamases
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Clin Microbiol Rev 22:161-82, Table of Contents. 2009
  7. pmc Carbapenemases: the versatile beta-lactamases
    Anne Marie Queenan
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Clin Microbiol Rev 20:440-58, table of contents. 2007
  8. ncbi Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 60:913-20. 2007
  9. doi Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Infect Dis 201:81-91. 2010
  10. ncbi Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe
    R Canton
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Clin Microbiol Infect 14:144-53. 2008

Detail Information

Publications236 found, 100 shown here

  1. doi Citrobacter infections in a general hospital: characteristics and outcomes
    G Samonis
    Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Greece
    Eur J Clin Microbiol Infect Dis 28:61-8. 2009
    ..02). The isolation of Citrobacter species, although rather infrequent, was clinically relevant in the great majority of cases. Further attention should be paid to these pathogens...
  2. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
    ..Thus, more rapid diagnostic testing of ESBL-producing bacteria and the possible modification of guidelines for community-onset bacteraemia associated with UTIs are required...
  3. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
    ..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
  4. ncbi The CTX-M beta-lactamase pandemic
    Rafael Canton
    Servicio de Microbiologia, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Curr Opin Microbiol 9:466-75. 2006
    ..All these events might have contributed to the current pandemic CTX-M beta-lactamase scenario...
  5. doi Infections with extended-spectrum beta-lactamase-producing enterobacteriaceae: changing epidemiology and drug treatment choices
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada
    Drugs 70:313-33. 2010
    ....
  6. pmc AmpC beta-lactamases
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Clin Microbiol Rev 22:161-82, Table of Contents. 2009
    ....
  7. pmc Carbapenemases: the versatile beta-lactamases
    Anne Marie Queenan
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Clin Microbiol Rev 20:440-58, table of contents. 2007
    ..This review updates the characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria...
  8. ncbi Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 60:913-20. 2007
    ..We performed a systematic review and meta-analysis to examine the impact of extended-spectrum beta-lactamase (ESBL) production on mortality and delay in effective therapy in Enterobacteriaceae bacteraemia...
  9. doi Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Infect Dis 201:81-91. 2010
    ..Therefore, the aims of this study were to characterize Citrobacter rodentium infection in neonatal mice and determine the role played by specific probiotics in ameliorating disease severity...
  10. ncbi Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe
    R Canton
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Clin Microbiol Infect 14:144-53. 2008
    ....
  11. doi Extended-spectrum beta-lactamase-producing organisms
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    J Hosp Infect 73:345-54. 2009
    ..Tigecycline and polymyxins have substantial antimicrobial activity against ESBL-producing Enterobacteriaceae, and, along with fosfomycin, merit further evaluation...
  12. pmc Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
    Chi Hye Park
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 50:3953-5. 2006
    ..aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes...
  13. pmc Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species
    Eva Kucerova
    School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom
    PLoS ONE 5:e9556. 2010
    ..The most severe diseases are caused in neonates and include fatal necrotizing enterocolitis and meningitis. The genetic basis of the diversity within the genus is unknown, and few virulence traits have been identified...
  14. pmc How to detect NDM-1 producers
    Patrice Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    J Clin Microbiol 49:718-21. 2011
    ..Colonies growing on these screening media can be verified as NDM-1 producers with molecular methods as described herein...
  15. doi Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis
    V S Conlin
    Division of Gastroenterology, Child and Family Research Institute, BC Children s Hospital, Vancouver, BC, Canada
    Am J Physiol Gastrointest Liver Physiol 297:G735-50. 2009
    ..In conclusion, our results indicate that VIP protects the colonic epithelial barrier by minimizing bacterial-induced redistribution of tight junction proteins in part through actions on MLCK and MLC phosphorylation...
  16. ncbi Is surveillance for multidrug-resistant enterobacteriaceae an effective infection control strategy in the absence of an outbreak?
    Michael A Gardam
    Infection Prevention and Control Unit, Toronto General Hospital, Toronto, Ontario, Canada M5G 2C4
    J Infect Dis 186:1754-60. 2002
    ..The annual cost of a surveillance program was calculated at Canadian $1,130,184.44. Thus, the routine and costly use of MDRE surveillance and isolation precautions are not warranted in the absence of a clonal outbreak in this population...
  17. doi Surveillance of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in a Swiss Tertiary Care Hospital
    C Fankhauser
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Swiss Med Wkly 139:747-51. 2009
    ....
  18. doi Distribution of cotrimoxazole resistance genes associated with class 1 integrons in clinical isolates of Enterobacteriaceae in a university hospital in Tunisia
    Safia Dahmen
    Infections with multiresistant bacteria to antibiotics UR 29 04, Department of Microbiology, University Hospital of Sahloul, Sousse, Tunisia
    Microb Drug Resist 16:43-7. 2010
    ..The types, combinations, and frequency of the gene cassettes in integrons provide useful data for the surveillance of antimicrobial resistance in our hospital and for the prescription practice of cotrimoxazole...
  19. doi Clinical epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae
    Nimish Patel
    Pharmacy Practice Department, Albany College of Pharmacy and Health Sciences, Albany, NY 12208 3492, USA
    J Antimicrob Chemother 66:1600-8. 2011
    ..This study characterizes factors associated with CIRE among two different source populations...
  20. ncbi Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics
    Kathene C Johnson-Henry
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 191:2106-17. 2005
    ..We sought to determine whether pretreatment of mice with a mixture of Lactobacillus rhamnosus and L. acidophilus probiotics would attenuate C. rodentium-induced colonic disease in mice...
  21. pmc Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda
    Joost J van Soest
    Institute of Biology, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    BMC Immunol 12:58. 2011
    ..In this study we used transcriptome profiling and quantitative RT-PCR to analyze the immune response induced by E. tarda immersion and injection...
  22. pmc Proportion of extended-spectrum ß-lactamase-producing Enterobacteriaceae in community setting in Ngaoundere, Cameroon
    Carine Magoué Lonchel
    Laboratory of Medical Microbiology, University of Liege, CHU Sart Tilman B23, B 4000 Liege, Belgium
    BMC Infect Dis 12:53. 2012
    ..The current study aimed to determine the proportion of ESBLs in Enterobacteriaceae isolated in the community and to analyse some risk factors associated with ESBL carriage...
  23. ncbi Identification and screening of carbapenemase-producing Enterobacteriaceae
    P Nordmann
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Clin Microbiol Infect 18:432-8. 2012
    ..Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media...
  24. doi The efficacy of infection control interventions in reducing the incidence of extended-spectrum β-lactamase-producing Enterobacteriaceae in the nonoutbreak setting: A systematic review
    Shannon Goddard
    Department of Medicine, University of Toronto, Canada
    Am J Infect Control 39:599-601. 2011
    ..Although 4 uncontrolled, retrospective studies were included in the review, no well designed prospective studies capable of informing infection control practice were identified, underscoring the urgent need for research in this area...
  25. doi Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression
    S Ghosh
    Department of Biology, University of British Columbia Okanagan, Kelowna, Canada
    Am J Physiol Gastrointest Liver Physiol 301:G39-49. 2011
    ..This study reveals that the microbiota is sufficient to overcome inherent genetic susceptibility patterns in C3H/HeOuJ mice that cause mortality during C. rodentium infection...
  26. doi Prospective evaluation of colonization with extended-spectrum beta-lactamase (ESBL)-producing enterobacteriaceae among patients at hospital admission and of subsequent colonization with ESBL-producing enterobacteriaceae among patients during hospitalizati
    Reuven Friedmann
    Department of Geriatrics, Shaare Zedek Medical Center, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Infect Control Hosp Epidemiol 30:534-42. 2009
    ..To determine the rates of and risk factors for carriage and acquisition of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae during hospitalization...
  27. doi From bench to bedside: stealth of enteroinvasive pathogens
    Renee M Tsolis
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, 95616 California, USA
    Nat Rev Microbiol 6:883-92. 2008
    ..Host responses contribute to the clinical presentation of disease and improved understanding of these responses in the laboratory is beginning to bridge the gap between bench and bedside...
  28. pmc Spread of OXA-48-encoding plasmid in Turkey and beyond
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 54:1369-73. 2010
    ..That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide...
  29. pmc Neonatal enteral feeding tubes as loci for colonisation by members of the Enterobacteriaceae
    Edward Hurrell
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
    BMC Infect Dis 9:146. 2009
    ..Enterobacter sakazakii) and other Enterobacteriaceae, and whether their presence was influenced by the feeding regime...
  30. ncbi Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens
    Mitsutoshi Iimura
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0623, USA
    J Immunol 174:4901-7. 2005
    ..Moreover, Cnlp+/+ mice were protected from oral infections with C. rodentium inocula that infected the majority of Cnlp-/- mice. These results establish cathelicidin as an important component of innate antimicrobial defense in the colon...
  31. ncbi Characterization of sulphonamide resistance genes and class 1 integron gene cassettes in Enterobacteriaceae, Central African Republic (CAR)
    Thierry Frank
    Institut Pasteur de Bangui, Bangui, Central African Republic
    J Antimicrob Chemother 59:742-5. 2007
    ....
  32. pmc Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen
    Kirk S B Bergstrom
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia, Canada
    Infect Immun 76:796-811. 2008
    ....
  33. ncbi Edwardsiellosis in fish: a brief review
    B R Mohanty
    Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar 751 002, India
    J Biosci 32:1331-44. 2007
    ..This article briefly discusses some of the recent research on edwardsiellosis, describing the pathogen's interaction with the host and environment, its pathogenesis and pathology as well as diagnostic, preventive and control measures...
  34. pmc Isolation of imipenem-resistant Enterobacter species: emergence of KPC-2 carbapenemase, molecular characterization, epidemiology, and outcomes
    Dror Marchaim
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 52:1413-8. 2008
    ..IRE infections are associated with increased mortality. Enhanced measures to control the hospital spread of IRE are warranted...
  35. pmc High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals
    Junying Ma
    College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues, South China Agricultural University, Guangzhou
    Antimicrob Agents Chemother 53:519-24. 2009
    ..PMQR determinants are highly prevalent in ceftiofur-resistant Enterobacteriaceae strains isolated from animals in China. This is the first report of the occurrence of PMQR determinants among isolates from companion animals...
  36. ncbi Prevalence of and risk factors associated with faecal carriage of CTX-M β-lactamase-producing Enterobacteriaceae in rural Thai communities
    Ulzii Orshikh Luvsansharav
    Department of Bioinformatics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Antimicrob Chemother 67:1769-74. 2012
    ..To determine the prevalence of CTX-M β-lactamase-producing Enterobacteriaceae and to study the risk factors associated with faecal carriage in asymptomatic rural Thai people...
  37. ncbi Unnoticed spread of integron-carrying Enterobacteriaceae in intensive care units
    S Nijssen
    Division of Acute Medicine and Infectious Diseases, University Medical Center Utrecht, The Netherlands
    Clin Infect Dis 41:1-9. 2005
    ..The prevalence of integrons and the incidence of cross-transmission and horizontal gene transfer in Enterobacteriaceae with reduced susceptibility to cephalosporins (ERSC) were determined for 2 intensive care units (ICUs)...
  38. pmc Prevalence of fecal carriage of acquired expanded-spectrum cephalosporin resistance in Enterobacteriaceae strains from cattle in France
    Jean Yves Madec
    J Clin Microbiol 46:1566-7. 2008
  39. ncbi Determining incidence of extended spectrum beta-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001-2002
    S K Bouchillon
    Laboratories International for Microbiology Studies, 2122 Palmer Road, Schaumburg, IL 60173 3817, USA
    Int J Antimicrob Agents 24:119-24. 2004
    ..4% (294/908) and 8.7% (83/949), respectively. PEARLS provides baseline data against which prospective changes in resistant determinants and outcomes can be measured in this ongoing study...
  40. doi Ertapenem-resistant Enterobacteriaceae: risk factors for acquisition and outcomes
    E P Hyle
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114 2696, USA
    Infect Control Hosp Epidemiol 31:1242-9. 2010
    ..We sought to determine risk factors for acquisition of ertapenem-resistant, meropenem-susceptible, or intermediate Enterobacteriaceae and to assess associated patient outcomes...
  41. doi Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay
    Spyros Pournaras
    Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece
    Int J Antimicrob Agents 37:244-7. 2011
    ..Additional in vivo tests are warranted to assess better the killing kinetics of tigecycline combinations against KPC-producers...
  42. ncbi Control of a prolonged outbreak of extended-spectrum beta-lactamase-producing enterobacteriaceae in a university hospital
    J C Lucet
    Unité d hygiène et de lutte contre l infection nosocomiale, Group Hospitalier Bichat Claude Bernard, Paris, France jean christophe
    Clin Infect Dis 29:1411-8. 1999
    ..The outbreak was effectively controlled without restricting antimicrobial use...
  43. pmc Escherichia albertii in wild and domestic birds
    J Lindsay Oaks
    Washington Animal Disease Diagnostic Laboratory, Washington State University, PO Box 647034, Pullman, WA 99164 7034, USA
    Emerg Infect Dis 16:638-46. 2010
    ..Genetic analysis of eae and cdtB sequences, multilocus sequence typing, and pulsed-field gel electrophoresis patterns showed that the E. albertii strains from birds are heterogeneous but similar to isolates that cause disease in humans...
  44. ncbi Extended-spectrum beta-lactamases and the permeability barrier
    L Martinez-Martinez
    Service of Microbiology, University Hospital Marques de Valdecilla, Santander, Spain
    Clin Microbiol Infect 14:82-9. 2008
    ..Porin loss also decreases the susceptibility to other non-beta-lactam compounds, such as fluoroquinolones, of ESBL-producing organisms...
  45. ncbi Characterization of Edwardsiella tarda strains isolated from turbot, Psetta maxima (L.)
    N Castro
    Departamento de Microbiologia y Parasitologia, Facultad de Biología e Instituto de Acuicultura, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    J Fish Dis 29:541-7. 2006
    ..tarda strains from turbot were compiled in a unique group using the primers P3 and P6, two clonal lineages could be detected when oligonucleotides P4 and P5 were employed...
  46. ncbi Control of Enterobacteriaceae producing extended-spectrum beta-lactamase in intensive care units: rectal screening may not be needed in non-epidemic situations
    Michelle Thouverez
    Service d Hygiène Hospitalière et d Épidémiologie Moléculaire, CHU Jean Minjoz, Besancon Cedex, France
    Infect Control Hosp Epidemiol 25:838-41. 2004
    ..To evaluate the usefulness of screening cultures in the control of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in intensive care units (ICUs)...
  47. pmc Genetic loci of major antigenic protein genes of Edwardsiella tarda
    Noel Verjan
    Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4 5 7 Konan, Minato, Tokyo 108 8477, Japan
    Appl Environ Microbiol 71:5654-8. 2005
    ..These genes and their products are useful for developing DNA or recombinant subunit vaccines to control edwardsiellosis...
  48. ncbi Citrobacter rodentium of mice and man
    Rosanna Mundy
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London SW7 2AZ, UK
    Cell Microbiol 7:1697-706. 2005
    ..Here we review the literature of C. rodentium from its emergence in the mid-1960s to the most contemporary reports of colonization, pathogenesis, transmission and immunity...
  49. ncbi Characterization and molecular epidemiology of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in a Tunisian University Hospital
    Safia Dahmen
    Infections with multiresistant bacteria to antibiotics UR 29 04, Department of Microbiology, University Hospital of Sahloul, Sousse, Tunisia
    Microb Drug Resist 16:163-70. 2010
    ..This study confirms the high rate of ESBLs in Tunisia and further demonstrates the worldwide spread of genes coding for CTX-M-15 enzymes in clinical isolates...
  50. pmc First descriptions of blaKPC in Raoultella spp. (R. planticola and R. ornithinolytica): report from the SENTRY Antimicrobial Surveillance Program
    Mariana Castanheira
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 47:4129-30. 2009
    ..All patients had received previous antimicrobial treatment, including carbapenems. These strains harbored bla(KPC-2) and bla(KPC-3). Carbapenemase genes were embedded in isoforms of Tn4401 and were plasmidic and chromosomal in location...
  51. ncbi New Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised
    Payal Deshpande
    Dept of Research, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India
    J Assoc Physicians India 58:147-9. 2010
    ..Many of them were recently hospitalized in India and Pakistan and had new type of metallo beta lactamase designated as New Delhi Metallo-1 (NDM-1)...
  52. ncbi Construction and evaluation of DNA vaccines encoding Edwardsiella tarda antigens
    Xu dong Jiao
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Vaccine 27:5195-202. 2009
    ..Furthermore, the induction magnitudes of most of these genes were significantly higher in pCE6-vaccinated fish than in pEta6-vaccinated fish...
  53. ncbi Molecular diagnosis of Raoultella planticola infection of a surgical site
    R Wolcott
    Southwest Regional Wound Care Center, Lubbock, Texas, USA
    J Wound Care 19:329-32. 2010
    ..This pathogen was diagnosed with rapid clinical molecular pathogen diagnostic methods, which allowed an appropriate therapy to be implemented, thereby improving prognosis...
  54. ncbi Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia
    S A Luperchio
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56-787B, Cambridge, Massachusetts 02139, USA
    Microbes Infect 3:333-40. 2001
    ..C. rodentium serves as an important model pathogen for investigating the mechanisms controlling attaching and effacing pathology, epithelial hyperproliferation, and tumor promotion in the distal colon of the mouse...
  55. doi Disparity in infection control practices for multidrug-resistant Enterobacteriaceae
    Christopher Lowe
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Am J Infect Control 40:836-9. 2012
    ..In this context, we expect that infection control practices for these organisms vary widely between hospitals...
  56. ncbi Protection of tilapia (Oreochromis mosambicus) from edwardsiellosis by vaccination with Edwardsiella tarda ghosts
    Se Ryun Kwon
    Department of Aquatic Life Medicine, Pukyong National University, Pusan 608 737, Republic of Korea
    Fish Shellfish Immunol 20:621-6. 2006
    ..As this promising type of a non-living whole cell envelope preparation seems to be favorable over conventional vaccines, we suggest E. tarda ghosts as a new vaccine candidate...
  57. pmc Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo
    Valerie F Crepin
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK
    Mol Microbiol 75:308-23. 2010
    ..Importantly, wild-type C. rodentium out-competed the tir tyrosine mutants during mixed infections. These results uncouple the Tir:Nck and Tir:IRTKS pathways from A/E lesion formation in vivo but assign them an important in vivo role...
  58. doi Analysis of the vaccine potential of a natural avirulent Edwardsiella tarda isolate
    Shuang Cheng
    Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, PR China
    Vaccine 28:2716-21. 2010
    ..These results indicated that ATCC 15947 possesses good immunoprotective potential, which may be exploited in the development of E. tarda vaccines...
  59. pmc EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics
    Sivan Dahan
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 73:679-86. 2005
    ....
  60. doi Dissemination of the CTX-M-25 family beta-lactamases among Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae and identification of the novel enzyme CTX-M-41 in Proteus mirabilis in Israel
    Shiri Navon-Venezia
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Antimicrob Chemother 62:289-95. 2008
    ..We aimed to describe the occurrence and to understand the dissemination of this extended-spectrum beta-lactamase family among Enterobacteriaceae strains in our hospital...
  61. doi Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance in carbapenem-resistant Enterobacter cloacae in China
    Qiong Wu
    Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People s Republic of China
    Diagn Microbiol Infect Dis 66:326-8. 2010
    ..bla(KPC-2) was located on a large nonconjugative plasmid, whereas armA was located on another conjugative plasmid. Although carbapenem-resistant Enterobacteriaceae remains rare, the emergence of this group of organism merits monitoring...
  62. pmc Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells
    Chien Chang Chen
    Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, 333, Taiwan
    Pediatr Res 65:169-75. 2009
    ..Up-regulated expression of a surface marker on DCs indicated that inoculation with probiotics will stimulate the function of DCs, thereby further increasing immune response triggered by DC...
  63. doi Spread of plasmids containing the bla(VIM-1) and bla(CTX-M) genes and the qnr determinant in Enterobacter cloacae, Klebsiella pneumoniae and Klebsiella oxytoca isolates
    Elisenda Miro
    Servei de Microbiologia, Hospital de Sant Pau, Barcelona, Spain
    J Antimicrob Chemother 65:661-5. 2010
    ....
  64. ncbi A case of severe pancreatitis complicated by Raoultella planticola infection
    M S Alves
    Departamento de Analises Clinicas, Universidade Federal de Juiz de Fora, Campus Universitario, Bairro Martelos, Juiz de Fora, MG 36036 330, Brazil
    J Med Microbiol 56:696-8. 2007
    ..R. planticola is difficult to identify in the clinical laboratory, and the clinical significance of this isolation remains uncharacterized. This is the first report of pancreatitis with a primary infection by R. planticola...
  65. pmc Citrobacter spp. simultaneously harboring blaCTX-M, blaTEM, blaSHV, blaampC, and insertion sequences IS26 and orf513: an evolutionary phenomenon of recent concern for antibiotic resistance
    M Shahid
    Section of Antimicrobial Agents and Drug Resistance Research and Microbial Biotechnology, Department of Medical Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
    J Clin Microbiol 48:1833-8. 2010
    ..It perhaps also suggests a "turnover" of these mobile elements in the population over time...
  66. ncbi Prevalence and clonality of extended-spectrum beta-lactamases in Asia
    P M Hawkey
    Division of Immunity and Infection, University of Birmingham, Birmingham and Health Protection Agency, West Midlands Public Health Laboratory, Birmingham Heart of England NHS Trust, Bordesley Green East, Birmingham, UK
    Clin Microbiol Infect 14:159-65. 2008
    ..The high prevalence of ESBL genes in Asia means that the empirical treatment of serious infections with beta-lactam antibiotics, except carbapenems, is seriously compromised...
  67. ncbi Emergence of a 'hyperinfectious' bacterial state after passage of Citrobacter rodentium through the host gastrointestinal tract
    Siouxsie Wiles
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
    Cell Microbiol 7:1163-72. 2005
    ..In addition, the 'hyperinfectious' phenotype was found to be transient with one overnight passage in rich medium sufficient to return C. rodentium to 'culture' infectivity...
  68. ncbi Extended-spectrum beta-lactamases in Taiwan: epidemiology, detection, treatment and infection control
    Wen Liang Yu
    Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan County, Taiwan
    J Microbiol Immunol Infect 39:264-77. 2006
    ....
  69. ncbi Development of an effective Edwardsiella tarda vaccine for cultured turbot (Scophthalmus maximus)
    N Castro
    Departamento de Microbiologia y Parasitologia, Facultad de Biología CIBUS and Instituto de Acuicultura, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Fish Shellfish Immunol 25:208-12. 2008
    ..On the basis of the results obtained we recommend the i.p. administration of a non-mineral oil adjuvanted vaccine via i.p., which confers RPS values over 90% at least 6 months post-vaccination...
  70. pmc Community-onset disease caused by Citrobacter freundii producing a novel CTX-M beta-lactamase, CTX-M-30, in Canada
    Baha Abdalhamid
    Center for Research in Antiinfectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Antimicrob Agents Chemother 48:4435-7. 2004
    ..Sequencing of PCR products by use of CTX-M-specific primers revealed a new combination of four amino acid substitutions. This new gene was designated bla(CTX-M-30) and was encoded on a 3-kb plasmid. The pI of CTX-M-30 was 8.0...
  71. ncbi Desmosomes are unaltered during infections by attaching and effacing pathogens
    Julian A Guttman
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Anat Rec (Hoboken) 290:199-205. 2007
    ..Our data suggest that, unlike tight junctions, the desmosome protein levels and localization, as well as desmosome morphology, are unaltered during A/E pathogenesis...
  72. doi Predominance of CTX-M-type extended-spectrum beta-lactamase genes among enterobacterial isolates from outpatients in Brazil
    Luciene A R Minarini
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Diagn Microbiol Infect Dis 65:202-6. 2009
    ..Eleven isolates (4.2%) harbored a bla(CTX-M-2) gene, 3 isolates bla(CTX-M-9), 2 isolates bla(CTX-M-8), and 6 isolates bla(SHV-5). Two novel bla(CTX-M-2) variants, namely, bla(CTX-M-74) and bla(CTX-M-75), were identified...
  73. ncbi Endophthalmitis caused by Citrobacter species
    Kuan Jen Chen
    Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine Kwei Shan, Taoyuan, Taiwan
    Ocul Immunol Inflamm 16:147-53. 2008
    ..To investigate clinical settings, treatments, antibiotic sensitivities, and visual outcomes associated with endophthalmitis caused by Citrobacter species...
  74. ncbi Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae
    Claudia Lupp
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Cell Host Microbe 2:204. 2007
    ..These findings underscore the importance of intestinal microbial ecosystems in infectious colitis and noninfectious intestinal inflammatory conditions,such as inflammatory bowel disease...
  75. ncbi A nosocomial outbreak due to novel CTX-M-2-producing strains of Citrobacter koseri in a hematological ward
    Tsuyoshi Muta
    Department of Hematology, Hamanomachi Hospital, Fukuoka 810 8539, Japan
    Jpn J Infect Dis 59:69-71. 2006
  76. doi Trends of methicillin-resistant Staphylococcus aureus (MRSA) and Enterobacteriaceae-producing extended-spectrum beta-lactamase (ESBLE) in eastern France: a three-year multi-centre incidence study
    X Bertrand
    Service d Hygiène Hospitalière, Centre Hospitalier Universitaire Besançon, Besancon, France
    Eur J Clin Microbiol Infect Dis 27:1113-7. 2008
    ..However, the diffusion of ESBLE-producing E. coli is a matter of concern and should be carefully monitored...
  77. ncbi Clinical and molecular epidemiology of multidrug-resistant Citrobacter spp. infections in a French university hospital
    J P Lavigne
    Institut National de la Sante et de la Recherche Medicale, ESPRI 26, UFR de Medecine, Avenue Kennedy, 30908, Nîmes Cedex 02, France
    Eur J Clin Microbiol Infect Dis 26:439-41. 2007
  78. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae in Bulgarian hospitals
    Rumyana Markovska
    Microbiology, Medical University, Sofia, Bulgaria
    Microb Drug Resist 14:119-28. 2008
    ..Our data contribute to clarify the dynamics in the prevalence of ESBLs in Bulgaria and demonstrate the importance of molecular procedures for their analysis...
  79. ncbi Dissemination of CTX-M type beta-lactamases in Enterobacteriaceae isolates in the People's Republic of China
    C J Munday
    Division of Immunobiology and Infection, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK
    Int J Antimicrob Agents 23:175-80. 2004
    ..After comparison with other previously published studies in the English language, we conclude that the most prevalent bla(CTX-M) so far reported in Asia are bla(CTX-M-14) and bla(CTX-M-3)...
  80. pmc Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice
    Bruce A Vallance
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Infect Immun 70:6424-35. 2002
    ..rodentium infection. However, the selective expression of iNOS by uninfected but not infected cells suggests that this pathogen has developed mechanisms to locally limit its exposure to host-derived NO...
  81. pmc Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum beta-lactamase gene blaCTX-M-3
    M Gołebiewski
    Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Antimicrob Agents Chemother 51:3789-95. 2007
    ..This suggests that plasmids of environmental bacterial strains could be the source of those plasmids now observed in bacteria pathogenic for humans...
  82. pmc Community-wide response of the gut microbiota to enteropathogenic Citrobacter rodentium infection revealed by deep sequencing
    Christian Hoffmann
    University of Pennsylvania School of Medicine, Department of Microbiology, Philadelphia, PA 19104, USA
    Infect Immun 77:4668-78. 2009
    ..Thus, deep sequencing provides previously inaccessible information on how Citrobacter infection and clearance reshapes the gut microbial community in space and time...
  83. pmc Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes
    Adam Baldwin
    Biological Sciences Department, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    BMC Microbiol 9:223. 2009
    ..sakazakii and 16 strains of C. malonaticus, including the index strains used to define the biotypes. The strains were from clinical and non-clinical sources between 1951 and 2008 in USA, Canada, Europe, New Zealand and the Far East...
  84. pmc Mucin dynamics in intestinal bacterial infection
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
    PLoS ONE 3:e3952. 2008
    ..coli. Mucin glycoproteins are the main component of the first barrier that bacteria encounter in the intestinal tract...
  85. ncbi A conserved 37 kDa outer membrane protein of Edwardsiella tarda is an effective vaccine candidate
    Kenji Kawai
    Department of Aquaculture, Fish Disease Laboratory, Faculty of Agriculture, Research Institute of Molecular Genetics, Kochi University, Nankoku, Kochi 783 8502, Japan
    Vaccine 22:3411-8. 2004
    ..tarda. A specific antibody was also detected by using ELISA. This study suggests that the 37 kDa OMP is an effective potent vaccine candidate against different serotypes of E. tarda...
  86. doi First detection of plasmid-mediated, quinolone resistance determinants qnrA, qnrB, qnrS and aac(6')-Ib-cr in extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in Budapest, Hungary
    Dora Szabo
    J Antimicrob Chemother 62:630-2. 2008
  87. ncbi Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum beta-lactamase producing, Enterobacteriaceae infections: a systematic review
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Lancet Infect Dis 10:43-50. 2010
    ..8%) of the 80 patients evaluated. Initial clinical data support the use of fosfomycin for the treatment of urinary tract infections caused by these pathogens, although further research is needed...
  88. pmc Genotypic and phenotypic analysis of Enterobacter sakazakii strains from an outbreak resulting in fatalities in a neonatal intensive care unit in France
    J Caubilla-Barron
    School of Biomedical and Natural Sciences, Nottingham Trent University, Nottingham, UK
    J Clin Microbiol 45:3979-85. 2007
    ..It is possible that E. sakazakii strains differ in their pathogenicities, as shown by the range of symptoms associated with each pulsotype...
  89. doi Molecular characterisation of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. isolates at a tertiary-care centre in Lebanon
    S S Kanj
    Division of Infectious Diseases, American University of Beirut Medical Center, Beirut, Lebanon
    Clin Microbiol Infect 14:501-4. 2008
    ..The genes encoding CTX-M-15 and AAC(6')-Ib-cr were carried on a 90-kb plasmid of the pC15-1a or pCTX-15 type, which transferred both ESBL production and quinolone resistance from donors to transconjugants...
  90. pmc IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens
    Sara M Dann
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 180:6816-26. 2008
    ..Thus, IL-6 is an important regulator of host defense against C. rodentium by protecting the mucosa against ulcerations which can act as a microbial niche for the bacteria...
  91. ncbi Enterobacter sakazakii is a rare cause of neonatal septicemia or meningitis in VLBW infants
    Barbara J Stoll
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pediatr 144:821-3. 2004
    ..Only one case of ES sepsis was identified among 10660 neonates. These data suggest that outside of the epidemic situation, ES is very rare in very low birth weight infants...
  92. pmc Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies
    Christian Maaser
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 72:3315-24. 2004
    ..These results indicate that host defense against C. rodentium depends on B cells and IgG antibodies but does not require production or transepithelial transport of IgA or secreted IgM...
  93. pmc Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection
    Rosanna Mundy
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College, London SW7 2AZ, United Kingdom
    Infect Immun 72:2288-302. 2004
    ..In contrast, strains producing EspI and Map had significant colonization defects and resulted in dramatically reduced levels of hyperplasia, and they exhibited very different growth dynamics in mice than the wild-type strain exhibited...
  94. pmc Dissecting virulence: systematic and functional analyses of a pathogenicity island
    Wanyin Deng
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 101:3597-602. 2004
    ..Our findings provide significant insights into bacterial virulence mechanisms and disease...
  95. ncbi Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes
    Charleric Bornet
    Enveloppe Bacterienne, Perméabilité et Antibiotiques, EA2197, IFR48, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 05, Marseille Cedex, France
    Biochem Biophys Res Commun 301:985-90. 2003
    ..The overexpression of marA, involved in the genetic control of membrane permeability via porin and efflux pump expression, indicated the activation of the resistance genetic cascade in imipenem resistant variants...
  96. pmc TEM derivative-producing Enterobacter aerogenes strains: dissemination of a prevalent clone
    P Dumarche
    Faculte de Medecine, Laboratoire de Bacteriologie, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 46:1128-31. 2002
    ..A clonal strain was found for TEM-24- but also for TEM-3- and TEM-1- or 2-producing isolates. This study shows that there is a clonal strain dependent on acquisition of the TEM-type enzyme (TEM-24 and other TEM types)...
  97. pmc National epidemiologic surveys of Enterobacter aerogenes in Belgian hospitals from 1996 to 1998
    Y De Gheldre
    Service de Microbiologie, Laboratoire de Bacteriologie, Universite Libre de Bruxelles Hopital Erasme, 808 Route de Lennik, 1070 Brussels, Belgium
    J Clin Microbiol 39:889-96. 2001
    ..TEM-24 beta-lactamase was frequently harbored by one of these epidemic strains, which appeared to be genotypically related to a TEM-24-producing epidemic strain from France, suggesting international dissemination...
  98. ncbi Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era
    J N Martin
    Center for AIDS Prevention Studies and Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    J Infect Dis 180:1809-18. 1999
    ..A rapid increase in the use of prophylactic TMP-SMX in HIV disease was also observed during this time in San Francisco and is likely responsible for the increase in TMP-SMX resistance...
  99. pmc Countrywide spread of community- and hospital-acquired extended-spectrum beta-lactamase (CTX-M-15)-producing Enterobacteriaceae in Lebanon
    Carole Moubareck
    Laboratoire de Microbiologie, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris 5 Rene Descartes, Paris, France
    J Clin Microbiol 43:3309-13. 2005
    ..In addition to the fact that the present study highlights the emergence and the countrywide dissemination of CTX-M-15-producing E. coli in Lebanon, it represents the first report of an SHV-5a-producing C. freundii...
  100. ncbi Enterobacter sakazakii: a coliform of increased concern to infant health
    Joshua B Gurtler
    Center for Food Safety and Department of Food Science and Technology, University of Georgia, 1109 Experiment Street, Griffin, GA 30223 1797, USA
    Int J Food Microbiol 104:1-34. 2005
    ..Tolerance of the pathogen to environmental stresses, its behavior in powdered and rehydrated infant formulae and hazard analysis and risk management are discussed. Research needs are presented...
  101. pmc Nematode symbiont for Photorhabdus asymbiotica
    John G Gerrard
    Gold Coast Hospital, Southport, Queensland, Australia
    Emerg Infect Dis 12:1562-4. 2006
    ..Although the source of infection was previously unknown, we report that the bacterium is found in a symbiotic association with an insect-pathogenic soil nematode of the genus Heterorhabditis...

Research Grants84

  1. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    DANIELLE M contact ZERR; Fiscal Year: 2010
    ..3. To define the demographic, clinical, and bacterial factors associated with PBLR in Enterobacteriaceae infections in pediatric patients. Methods. A consortium of 4 pediatric hospitals is involved in this project...
  2. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle Zerr; Fiscal Year: 2009
    ..3. To define the demographic, clinical, and bacterial factors associated with PBLR in Enterobacteriaceae infections in pediatric patients. Methods. A consortium of 4 pediatric hospitals is involved in this project...
  3. BARRIER FUNCTIONS OF THE GI TRACT IN HEALTH AND DISEASE
    W Walker; Fiscal Year: 1990
    ..Three core facilities, including a flow cytometry and molecular biology core, will be used to support these projects...
  4. EHEC interactions with the normal intestinal flora
    Vanessa Sperandio; Fiscal Year: 2004
    ..In Specific Aim 2, we propose to monitor EHEC virulence gene expression in a mixed population in the presence of the intestinal flora. ..
  5. Quorum sensing regulation of EHEC virulence genes
    Vanessa Sperandio; Fiscal Year: 2007
    ..abstract_text> ..
  6. Quorum sensing regulation of EHEC virulence genes
    Vanessa Sperandio; Fiscal Year: 2009
    ....
  7. Screen for Quorum Sensing Molecular Inhibitors (RMI)
    Vanessa Sperandio; Fiscal Year: 2005
    ....
  8. Stellenbosch University Clinical Trial Unit, Cape Town, South Africa
    Mark Cotton; Fiscal Year: 2008
    ..James Mclntyre, Perinatal HIV Research Unit ACTG, Witwatersrand University. Though this co-mentoring partnership, the AIDs CRS is expected to be able to enroll subjects within six months of funding. ADMINISTRATIVE COMPONENT: ..
  9. MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATION
    Lars Eckmann; Fiscal Year: 2008
    ..abstract_text> ..
  10. Optimizing Dosing of Colistin for Infections Resistant to all Other Antibiotics
    Fernanda Silveira; Fiscal Year: 2007
    ....
  11. Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilis
    CYNTHIA SEARS; Fiscal Year: 2008
    ....
  12. Genetic Analysis of Zebrafish Biliary Mutants
    Randolph Matthews; Fiscal Year: 2007
    ..These studies in zebrafish may provide clues as to biliary development in mammals and to genetic contributions to cholestatic diseases in humans [unreadable] [unreadable]..
  13. Gut to Brain Pathways for Infection-Induced Anxiety
    Mark Lyte; Fiscal Year: 2005
    ..abstract_text> ..
  14. Molecular Epidemiology, Virulence, and Genomic Characterization of Ureaplasmas
    Ken Waites; Fiscal Year: 2007
    ....
  15. Stellenbosch University Clinical Trial Unit, Cape Town, South Africa
    Mark Cotton; Fiscal Year: 2007
    ..James Mclntyre, Perinatal HIV Research Unit ACTG, Witwatersrand University. Though this co-mentoring partnership, the AIDs CRS is expected to be able to enroll subjects within six months of funding. ADMINISTRATIVE COMPONENT: ..
  16. Immune Responses to Biodefense Vaccines Early in Life
    MARCELA PASETTI; Fiscal Year: 2006
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effective vaccines to prevent diseases early in life. [unreadable] [unreadable] [unreadable]..
  17. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2007
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
  18. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2006
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
  19. Analysis of zebrafish biliary mutants
    Randolph Matthews; Fiscal Year: 2008
    ..Many of these genes are likely to be involved in mammalian biliary development; abnormalities in these genes may be associated with specific neonatal biliary diseases. ..
  20. EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODE
    David Nix; Fiscal Year: 2008
    ..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
  21. Impact of Social Stress on TLR4-Induced Microbicidal Activity of CD11b+ Cells
    Michael Bailey; Fiscal Year: 2008
    ..Defining the stress-induced cellular changes that enhance immune functioning could stimulate new therapeutic approaches to treating infectious diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
  22. Reducing Antimicrobial Use Associated with Ventilator Associated Pneumonia and Ca
    SARA ELIZABETH COSGROVE; Fiscal Year: 2010
    ..We hypothesize that this approach will enhance appropriate use of antimicrobials for both VAP and CAUTI and improve patient outcomes by reducing the known sequelae of antimicrobial overuse. ..
  23. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard Guerrant; Fiscal Year: 2009
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
  24. Crimson - i2b2 integration for high-throughput, scalable sample collection
    Lynn Bry; Fiscal Year: 2010
    ....
  25. Molecular Detection of Blood Stream Infections in Women with Gynecologic Cancer
    Jeanne Ann Jordan; Fiscal Year: 2010
    ..abstract_text> ..
  26. Genetic Network Linking Immunity to Energetic Stress, Metabolism and Reproduction
    BRIAN LAZZARO; Fiscal Year: 2009
    ..REVISED PUBLIC HEALTH RELEVANCE STATEMENT SECTION Program Director/Principal Investigator (Last, First, Middle): Swain, Susan L. 1R01 AI076534-01A1 NO text ..
  27. Crimson - i2b2 integration for high-throughput, scalable sample collection
    Lynn Bry; Fiscal Year: 2009
    ....
  28. Reducing Antimicrobial Use Associated with Ventilator Associated Pneumonia and Ca
    Sara Cosgrove; Fiscal Year: 2009
    ..We hypothesize that this approach will enhance appropriate use of antimicrobials for both VAP and CAUTI and improve patient outcomes by reducing the known sequelae of antimicrobial overuse. ..
  29. EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODE
    David Nix; Fiscal Year: 2009
    ..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
  30. APOE and the Effects of Malnutrition on Cognitive and Intestinal Development
    Richard Guerrant; Fiscal Year: 2009
    ..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
  31. Mutant NOD2 in Intestinal Inflammation and Host Defense
    Lars Eckmann; Fiscal Year: 2009
    ..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
  32. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2009
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
  33. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2009
    ..Our studies may indicate that a common stool bacterium is oncogenic and contributes to colon cancer risk. If so, these data will lead to new public health approaches to the prevention of colon cancer. ..
  34. Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilis
    CYNTHIA SEARS; Fiscal Year: 2009
    ....
  35. Fungal infections and tolerogenic immunosuppression
    Fernanda Silveira; Fiscal Year: 2008
    ..Therefore, another major aim of the study is to serially collect serum and urine on consecutive transplant recipients with a view to having a "bank" on which to test new diagnostic methodologies. ..
  36. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2008
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  37. Molecular Detection of Blood Stream Infections in Women with Gynecologic Cancer
    Jeanne Ann Jordan; Fiscal Year: 2011
    ..abstract_text> ..
  38. Role of T cells in self-limited mucosal infections
    Lynn Bry; Fiscal Year: 2006
    ..This training provides a necessary step in the candidate's goal to become an independent researcher investigating questions in mucosal immunology and host-microbial cross-talk in intestinal environments. ..
  39. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2005
    ....
  40. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 1999
    ..This three-pronged approach will advance our understanding of the molecular pathogenesis of ETBF infections and will serve to delineate in much greater detail the cellular mechanism of action of BFT. ..
  41. DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUES
    JEANNE JORDAN; Fiscal Year: 2002
    ....
  42. DIFERENTIAL ACTIVATION OF THE VITAMIN D RECEPTOR
    Sara Peleg; Fiscal Year: 2002
    ..These studies will facilitate the development of selective vitamin D receptor modulators that may be useful for treatment of various clinical conditions, including osteoporosis, secondary hyperparathyroidism, and cancer. ..
  43. Gut to Brain Pathways for Infection-Induced Anxiety
    Mark Lyte; Fiscal Year: 2002
    ..abstract_text> ..
  44. DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUES
    JEANNE JORDAN; Fiscal Year: 2001
    ....
  45. PLASMID MEDIATED QUINOLONE RESISTANCE
    George Jacoby; Fiscal Year: 2001
    ..Understanding how qnr acts may help to curtail the rise in quinolone resistance and may also provide fundamental insights into aspects of DNA replication. ..
  46. MOLECULAR MECHANISMS OF EIAV PERSISTENCE
    JERALD OAKS; Fiscal Year: 2001
    ..These studies will provide insight into HIV persistence in HAART patients, and potentially provide a model that can be used to evaluate strategies for actual elimination of lentiviral infections. ..
  47. Pathogenicity of Enterotoxigenic Bacteriodes Fragilis
    CYNTHIA SEARS; Fiscal Year: 2001
    ..We hypothesize that ETBF is an under-recognized intestinal pathogen accounting for a portion of previously undiagnosed inflammatory intestinal infections in both children and adults. ..
  48. APOPTOSIS IN SHIGELLA INFECTIONS
    Arturo Zychlinsky; Fiscal Year: 2000
    ..abstract_text> ..
  49. PLASMID MEDIATED QUINOLONE RESISTANCE
    George Jacoby; Fiscal Year: 2000
    ..Understanding how qnr acts may help to curtail the rise in quinolone resistance and may also provide fundamental insights into aspects of DNA replication. ..
  50. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 1993
    ..fragilis...
  51. APOPTOSIS IN SHIGELLA INFECTIONS
    Arturo Zychlinsky; Fiscal Year: 2003
    ..abstract_text> ..
  52. NEUROENDOCRINE MEDIATION OF E. COLI 0157:H7 INFECTION
    Mark Lyte; Fiscal Year: 2003
    ..The demonstration of direct neuroendocrine-bacterial interaction as a mechanism in the pathogenesis of E. coli O157:H7 infection may yield new treatments for both the prevention and treatment of hemorrhagic colitis. ..
  53. HOST DEFENSES AGAINST PATHOGENIC E. coli
    Lars Eckmann; Fiscal Year: 2006
    ..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
  54. LONG-TERM IMPACT AND INTERVENTION FOR DIARRHEA IN BRAZIL
    Richard Guerrant; Fiscal Year: 2007
    ....
  55. MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATION
    Lars Eckmann; Fiscal Year: 2005
    ..abstract_text> ..
  56. Physiology and Cloning of B. Fragilis Enterotoxin
    CYNTHIA SEARS; Fiscal Year: 2004
    ..abstract_text> ..
  57. MOLECULAR MECHANISMS OF EIAV PERSISTENCE
    JERALD OAKS; Fiscal Year: 1999
    ..These studies will provide insight into HIV persistence in HAART patients, and potentially provide a model that can be used to evaluate strategies for actual elimination of lentiviral infections. ..
  58. DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUES
    JEANNE JORDAN; Fiscal Year: 2003
    ....
  59. DIFFERENTIAL ACTIVATION OF THE VITAMIN D RECEPTOR
    Sara Peleg; Fiscal Year: 1999
    ..The specific DNA sequences that bind will be extracted from the receptor/DNA complexes, amplified by the polymerase chain reaction, sequenced and tested for transcriptional activity by DNA-transfer methods. ..
  60. PLASMID MEDIATED QUINOLONE RESISTANCE
    George Jacoby; Fiscal Year: 1999
    ..Understanding how qnr acts may help to curtail the rise in quinolone resistance and may also provide fundamental insights into aspects of DNA replication. ..
  61. Molecular Detection of Blood Stream Infections in Women with Gynecologic Cancer
    JEANNE JORDAN; Fiscal Year: 2009
    ....
  62. DIFERENTIAL ACTIVATION OF THE VITAMIN D RECEPTOR
    Sara Peleg; Fiscal Year: 2000
    ..These studies will facilitate the development of selective vitamin D receptor modulators that may be useful for treatment of various clinical conditions, including osteoporosis, secondary hyperparathyroidism, and cancer. ..
  63. MOLECULAR MECHANISMS OF EIAV PERSISTENCE
    JERALD OAKS; Fiscal Year: 2000
    ..These studies will provide insight into HIV persistence in HAART patients, and potentially provide a model that can be used to evaluate strategies for actual elimination of lentiviral infections. ..
  64. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  65. DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUES
    JEANNE JORDAN; Fiscal Year: 2000
    ....
  66. DIFERENTIAL ACTIVATION OF THE VITAMIN D RECEPTOR
    Sara Peleg; Fiscal Year: 2001
    ..These studies will facilitate the development of selective vitamin D receptor modulators that may be useful for treatment of various clinical conditions, including osteoporosis, secondary hyperparathyroidism, and cancer. ..
  67. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2003
    ....
  68. DIFERENTIAL ACTIVATION OF THE VITAMIN D RECEPTOR
    Sara Peleg; Fiscal Year: 2003
    ..These studies will facilitate the development of selective vitamin D receptor modulators that may be useful for treatment of various clinical conditions, including osteoporosis, secondary hyperparathyroidism, and cancer. ..
  69. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2004
    ....
  70. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  71. Impact of Social Stress on TLR4-Induced Microbicidal Activity of CD11b+ Cells
    Michael Bailey; Fiscal Year: 2007
    ..Defining the stress-induced cellular changes that enhance immune functioning could stimulate new therapeutic approaches to treating infectious diseases. [unreadable] [unreadable] [unreadable] [unreadable]..
  72. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2007
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  73. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2009
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  74. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    BRIAN LAZZARO; Fiscal Year: 2006
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..