Genomes and Genes
Summary: A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.
Publications275 found, 100 shown here
- Melioidosis: insights into the pathogenicity of Burkholderia pseudomalleiW Joost Wiersinga
Academic Medical Centre, Centre for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
Nat Rev Microbiol 4:272-82. 2006Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia...
- Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesisEdouard E Galyov
Department of Infection, Immunity and Inflammation, MSB, University of Leicester, Leicester LE1 9HN, United Kingdom
Annu Rev Microbiol 64:495-517. 2010..knowledge on the specific virulence factors employed by these pathogens and their roles in the pathogenesis of melioidosis and glanders...
- The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective studyBart J Currie
Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Casuarina, Northern Territory, Australia
PLoS Negl Trop Dis 4:e900. 2010Over 20 years, from October 1989, the Darwin prospective melioidosis study has documented 540 cases from tropical Australia, providing new insights into epidemiology and the clinical spectrum.
- Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleteriousIvonne Ceballos-Olvera
Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
PLoS Pathog 7:e1002452. 2011Burkholderia pseudomallei is a Gram-negative bacterium that infects macrophages and other cell types and causes melioidosis. The interaction of B...
- The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomalleiMary N Burtnick
Department of Microbiology and Immunology, University of South Alabama, Mobile, Alabama 36688, USA
Infect Immun 79:1512-25. 2011..recombinant Hcp proteins from each T6SS and tested them as vaccine candidates in the BALB/c mouse model of melioidosis. Recombinant Hcp2 protected 80% of mice against a lethal challenge with K96243, while recombinant Hcp1, Hcp3, ..
- Melioidosis: epidemiology, pathophysiology, and managementAllen C Cheng
Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Clin Microbiol Rev 18:383-416. 2005b>Melioidosis, caused by the gram-negative saprophyte Burkholderia pseudomallei, is a disease of public health importance in southeast Asia and northern Australia that is associated with high case-fatality rates in animals and humans...
- The global distribution of Burkholderia pseudomallei and melioidosis: an updateBart J Currie
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Trans R Soc Trop Med Hyg 102:S1-4. 2008While Southeast Asia and northern Australia are well recognized as the major endemic regions for melioidosis, recent reports have expanded the endemic zone...
- MelioidosisN J White
Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand
Lancet 361:1715-22. 2003b>Melioidosis, which is infection with the gram-negative bacterium Burkholderia pseudomallei, is an important cause of sepsis in east Asia and northern Australia...
- Increasing incidence of human melioidosis in Northeast ThailandDirek Limmathurotsakul
Department of Tropical Hygiene and Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 82:1113-7. 2010b>Melioidosis is a serious community-acquired infectious disease caused by the Gram-negative environmental bacterium Burkholderia pseudomallei...
- Toll-like receptor 4 region genetic variants are associated with susceptibility to melioidosisT E West
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
Genes Immun 13:38-46. 2012b>Melioidosis is a tropical infection caused by the Gram-negative soil saprophyte Burkholderia pseudomallei. Despite broad exposure of northeastern Thais, disease develops in only a small proportion of individuals...
- Genome wide transcriptome profiling of a murine acute melioidosis model reveals new insights into how Burkholderia pseudomallei overcomes host innate immunityChui Yoke Chin
School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi Selangor D E Malaysia
BMC Genomics 11:672. 2010..pseudomallei) interacts with its host to elicit melioidosis symptoms...
- Melioidosis: a clinical overviewDirek Limmathurotsakul
Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Br Med Bull 99:125-39. 2011b>Melioidosis, an infection caused by the environmental Gram-negative bacillus Burkholderia pseudomallei, has emerged as an important cause of morbidity and mortality in Southeast Asia and northern Australia.
- Dissection of the Burkholderia intracellular life cycle using a photothermal nanobladeChristopher T French
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 108:12095-100. 2011..Our data suggest that the primary means for intercellular spread involves cell fusion, as opposed to pseudopod engulfment and bacterial escape from double-membrane vacuoles...
- A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infectionWildaliz Nieves
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
Vaccine 29:8381-9. 2011..pseudomallei that can be exploited for other intracellular respiratory pathogens, including other Burkholderia and bacteria capable of establishing persistent infection...
- Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class modelsDirek Limmathurotsakul
Department of Tropical Hygiene, Mahidol University, Bangkok, Thailand
PLoS ONE 5:e12485. 2010....
- Rapid presumptive identification of Burkholderia pseudomallei with real-time PCR assays using fluorescent hybridization probesHerbert Tomaso
Federal Armed Forces Institute of Microbiology, Neuherbergstrasse 11, Munich 80937, Germany
Mol Cell Probes 19:9-20. 2005Burkholderia pseudomallei (the etiologic agent of melioidosis) can cause pyogenic or granulomatous lesions in almost any organ. Septicemia has a case fatality rate of >40%...
- Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosisRungnapa Pankla
Department of Clinical Immunology, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, 123 Mittraparp Road, Khon Kaen, 40002, Thailand
Genome Biol 10:R127. 2009b>Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, a Gram-negative bacillus classified by the National Institute of Allergy and Infectious Diseases (NIAID) as a category B priority agent...
- Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomalleiMatthew T G Holden
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
Proc Natl Acad Sci U S A 101:14240-5. 2004Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world and accounts for 20% of community-..
- Glyburide is anti-inflammatory and associated with reduced mortality in melioidosisGavin C K W Koh
Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Clin Infect Dis 52:717-25. 2011....
- Persistent gastric colonization with Burkholderia pseudomallei and dissemination from the gastrointestinal tract following mucosal inoculation of miceAndrew Goodyear
Department of Microbiology, Immunology, and Pathology, Rocky Mountain Regional Center for Excellence for Biodefense and Emerging Infectious Diseases Research, Colorado State University, Fort Collins, Colorado, United States of America
PLoS ONE 7:e37324. 2012b>Melioidosis is a disease of humans caused by opportunistic infection with the soil and water bacterium Burkholderia pseudomallei. Melioidosis can manifest as an acute, overwhelming infection or as a chronic, recurrent infection...
- Progress toward development of vaccines against melioidosis: A reviewMitali Sarkar-Tyson
Defence Science and Technology Laboratory, Salisbury, United Kingdom
Clin Ther 32:1437-45. 2010b>Melioidosis is a serious and often fatal disease that is prevalent in subtropical and tropical climates, primarily in at-risk groups (eg, those with diabetes, alcoholism, or other cause of immunosuppression)...
- Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomalleiNarisara Chantratita
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Proc Natl Acad Sci U S A 108:17165-70. 2011..a unique mechanism of β-lactam resistance in the biothreat organism Burkholderia pseudomallei (the cause of melioidosis), associated with treatment failure during prolonged ceftazidime therapy of natural infection...
- Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosisMichelle Nelson
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
J Med Microbiol 53:1177-82. 2004Burkholderia pseudomallei is the causative agent of melioidosis, which is a major cause of morbidity and mortality in endemic regions. Currently there is no human vaccine against melioidosis...
- An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogenMark P Stevens
Division of Environmental Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, UK
Mol Microbiol 46:649-59. 2002Burkholderia pseudomallei is the causative agent of melioidosis, a serious infectious disease of humans and animals that is endemic in subtropical areas. B...
- Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection modelJonathan Warawa
Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alta, Canada T2N 4N1
FEMS Microbiol Lett 242:101-8. 2005Burkholderia pseudomallei, the etiological agent of melioidosis, is an animal pathogen capable of inducing a highly fatal septicemia. B...
- Immunization with the recombinant Burkholderia pseudomallei outer membrane protein Omp85 induces protective immunity in miceYu Ching Su
School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia
Vaccine 28:5005-11. 2010Burkholderia pseudomallei is resistant to a wide range of antibiotics, leading to relapse and recrudescence of melioidosis after cessation of antibiotic therapy...
- Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosisErin P Price
Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America
PLoS Pathog 6:e1000725. 2010..Previous studies of Burkholderia pseudomallei, the etiologic agent of melioidosis, have shown that this opportunistic pathogen mutates rapidly both in vitro and in vivo at tandemly repeated ..
- Caspase-1 mediates resistance in murine melioidosisKatrin Breitbach
Friedrich Loeffler Institute of Medical Microbiology, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
Infect Immun 77:1589-95. 2009The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical areas...
- A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomalleiAnna Easton
London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom
J Infect Dis 195:99-107. 2007Inhalation is an important route of infection with Burkholderia pseudomallei, the causative agent of melioidosis. In resistant C57BL/6 mice, activated neutrophils are rapidly recruited to the lungs after intranasal B...
- Biodefense-driven murine model of pneumonic melioidosisJ A Jeddeloh
Bacteriology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
Infect Immun 71:584-7. 2003A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates...
- Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)W Joost Wiersinga
Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
PLoS Med 4:e248. 2007..b>Melioidosis is a severe infection caused by the gram-negative bacterium, Burkholderia pseudomallei, that is endemic in ..
- Indirect hemagglutination assay in patients with melioidosis in northern AustraliaAllen C Cheng
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Am J Trop Med Hyg 74:330-4. 2006b>Melioidosis is caused by the saprophytic organism Burkholderia pseudomallei. The use of the indirect hemagglutination assay (IHA) has found widespread use in areas endemic for this disease...
- Low-dose exposure of C57BL/6 mice to burkholderia pseudomallei mimics chronic human melioidosisLaura Conejero
Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Am J Pathol 179:270-80. 2011Burkholderia pseudomallei is the etiological agent of human melioidosis, a disease with a broad spectrum of clinical manifestations ranging from fatal septicemia to chronic localized infection or asymptomatic latent infection...
- Model of differential susceptibility to mucosal Burkholderia pseudomallei infectionBoping Liu
Department of Biochemistry Department of Microbiology, National University of Singapore, Singapore 119260
Infect Immun 70:504-11. 2002Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with protean clinical manifestations...
- Protection from pneumonic infection with burkholderia species by inhalational immunotherapyAndrew Goodyear
Department of Microbiology, Immunology and Pathology, Colorado State University, Ft Collins, CO 80523, USA
Infect Immun 77:1579-88. 2009Burkholderia mallei and B. pseudomallei are important human pathogens and cause the diseases glanders and melioidosis, respectively...
- Prospective clinical evaluation of the accuracy of 16S rRNA real-time PCR assay for the diagnosis of melioidosisNarisara Chantratita
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 77:814-7. 2007..of a Burkholderia pseudomallei 16s rRNA real-time PCR assay was evaluated against culture for the diagnosis of melioidosis in Thailand. A total of 846 samples were obtained from 383 patients with suspected melioidosis...
- Impaired early cytokine responses at the site of infection in a murine model of type 2 diabetes and melioidosis comorbidityKelly A Hodgson
Infectious Diseases and Immunopathogenesis Research Group, School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland, Australia
Infect Immun 81:470-7. 2013Bacterial infections are a common and serious complication of type 2 diabetes (T2D). The prevalence of melioidosis, an emerging tropical infection caused by the Gram-negative bacterium Burkholderia pseudomallei, is increased in people ..
- Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosisSuzzanne J Owen
Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
J Infect Dis 199:1761-70. 2009Burkholderia pseudomallei, the causative agent of melioidosis, is generally considered to be acquired via inhalation of dust or water droplets from the environment...
- Incidence, risk factors and clinical epidemiology of melioidosis: a complex socio-ecological emerging infectious disease in the Alor Setar region of Kedah, MalaysiaMuhammad R A Hassan
Imperial College London, London, UK
BMC Infect Dis 10:302. 2010b>Melioidosis, a severe and fatal infectious disease caused by Burkholderia pseudomallei, is believed to an emerging global threat...
- Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis)L M Kager
Center for Experimental and Molecular Medicine, Center for Infection and Immunity Amsterdam, Amsterdam, The Netherlands
J Thromb Haemost 9:2020-8. 2011b>Melioidosis is a frequent cause of sepsis in Southeast Asia caused by the Gram-negative bacterium Burkholderia pseudomallei...
- Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB/c and C57Bl/6 miceGek Yen Gladys Tan
Medical Countermeasures Laboratory, DSO National Laboratories, Singapore 117510
J Med Microbiol 57:508-15. 2008b>Melioidosis is caused by the Gram-negative bacterium Burkholderia pseudomallei, whose portals of entry into the body include subcutaneous, ingestion and inhalation routes...
- Antibiotic susceptibility of Burkholderia pseudomallei from tropical northern Australia and implications for therapy of melioidosisA W Jenney
Infectious Diseases Unit, Royal Darwin Hospital, Darwin, NT 0810, Australia
Int J Antimicrob Agents 17:109-13. 2001From a prospective melioidosis study commencing in 1989 at Royal Darwin Hospital, 170 initial isolates of Burkholderia pseudomallei were available for susceptibility testing...
- Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposesSharon J Peacock
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
PLoS Negl Trop Dis 6:e1488. 2012Burkholderia pseudomallei is a Category B select agent and the cause of melioidosis. Research funding for vaccine development has largely considered protection within the biothreat context, but the resulting vaccines could be applicable ..
- Prevalence of melioidosis in the Er-Ren River Basin, Taiwan: implications for transmissionHsun Pi Su
Centers for Disease Control, Department of Health Taiwan Institute of Veterinary Microbiology, National Chung Hsing University, Taichung, Taiwan
J Clin Microbiol 45:2599-603. 2007An increase in melioidosis cases compared to other areas in Taiwan was observed in the Er-Ren River Basin, southwestern Taiwan, from November 2001 to August 2006...
- A Burkholderia pseudomallei deltapurM mutant is avirulent in immunocompetent and immunodeficient animals: candidate strain for exclusion from select-agent listsKatie L Propst
Department of Microbiology, Immunology and Pathology, Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Colorado State University, Fort Collins, Colorado 80523 2025, USA
Infect Immun 78:3136-43. 2010Burkholderia pseudomallei causes the disease melioidosis in humans and is classified as a category B select agent...
- In Vitro and In Vivo studies of monoclonal antibodies with prominent bactericidal activity against Burkholderia pseudomallei and Burkholderia malleiShimin Zhang
Department of Environmental and Infectious Disease Sciences, American Registry of Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
Clin Vaccine Immunol 18:825-34. 2011..The result is compatible with that of our in vitro study. The MAbs with the highest protective efficacy are those reactive to either the capsular PS or LPS of the Burkholderia bacteria...
- The epidemiology of melioidosis in Australia and Papua New GuineaB J Currie
Division of Medicine, Royal Darwin Hospital Clinical School and Tropical Medicine and International Health Unit, Menzies School of Health Research, Casuarina, NT, Australia
Acta Trop 74:121-7. 2000b>Melioidosis was first described in Australia in an outbreak in sheep in 1949 in north Queensland (22 degrees S). Human melioidosis was first described from Townsville (19 degrees S) in 1950...
- The Burkholderia pseudomallei Δasd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in miceMichael H Norris
Department of Microbiology, University of Hawaii at Manoa, Manoa, HI, 96822, USA
Infect Immun 79:4010-8. 2011..to be avirulent in BALB/c mice, and mice vaccinated with the mutant were protected against acute inhalation melioidosis. Thus, the B...
- Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosisSarah A Ngugi
Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Vaccine 28:7551-5. 2010..pseudomallei can provide protection against a lethal challenge of B. pseudomallei in a mouse model of melioidosis. Sugar analysis on LPS from B...
- Melioidosis in MalaysiaS D Puthucheary
Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Med J Malaysia 64:266-74. 2009b>Melioidosis is an important cause of sepsis in the tropics, is caused by an environmental saprophyte--B. pseudomallei. It affects mainly adults with underlying predisposing condition such as diabetes...
- Melioidosis in northern Australia, 2001-02Allen C Cheng
Menzies School of Health Research, Darwin, Northern Territory
Commun Dis Intell Q Rep 27:272-7. 2003b>Melioidosis, caused by the gram negative bacterium Burkholderia pseudomallei, is endemic in northern Australia...
- Versatile dual-technology system for markerless allele replacement in Burkholderia pseudomalleiCarolina M Lopez
Department of Microbiology, Immunology and Pathology, Colorado State University, IDRC at Foothills Campus, Campus Delivery 2025, Fort Collins, CO 80523 2025, USA
Appl Environ Microbiol 75:6496-503. 2009Burkholderia pseudomallei is the etiologic agent of melioidosis, a rare but serious tropical disease. In the United States, genetic research with this select agent bacterium is strictly regulated...
- Cutaneous melioidosis in a man who was taken as a prisoner of war by the Japanese during World War IIViseth Ngauy
Wiford Hall Medical Center, Lackland Air Force Base, San Antonio, USA
J Clin Microbiol 43:970-2. 2005b>Melioidosis, an infection caused by the gram-negative bacillus Burkholderia pseudomallei, is endemic to Southeast Asia and Northern Australia...
- Flagella are virulence determinants of Burkholderia pseudomalleiK L Chua
Department of Biochemistry, National University of Singapore, Faculty of Medicine, 10 Kent Ridge Crescent, Singapore 119260
Infect Immun 71:1622-9. 2003..intracellular pathogen, is a flagellated and motile gram-negative bacterium and is the causative agent of melioidosis in humans...
- Intensity of rainfall and severity of melioidosis, AustraliaBart J Currie
Menzies School of Health Research and Flinders University, Darwin, Northern Territory, Australia
Emerg Infect Dis 9:1538-42. 2003In a 12-year prospective study of 318 culture-confirmed cases of melioidosis from the Top End of the Northern Territory of Australia, rainfall data for individual patient locations were correlated with patient risk factors, clinical ..
- Management of melioidosisVanaporn Wuthiekanun
Mahidol University, Faculty of Tropical Medicine, Bangkok, Thailand
Expert Rev Anti Infect Ther 4:445-55. 2006b>Melioidosis is a serious human infection caused by the environmental Gram-negative bacterium Burkholderia pseudomallei. Outcome following melioidosis remains poor despite 20 years of clinical research...
- Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomalleiNarisara Chantratita
Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
J Bacteriol 189:807-17. 2007b>Melioidosis is a notoriously protracted illness and is difficult to cure...
- Present and future therapeutic strategies for melioidosis and glandersD Mark Estes
Department of Microbiology and Immunology, Department of Pathology and The Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
Expert Rev Anti Infect Ther 8:325-38. 2010Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. Both Gram-negative pathogens are endemic in many parts of the world...
- Burkholderia pseudomallei: animal models of infectionRichard W Titball
School of Biosciences, Geoffrey Pope Building, University of Exeter, Exeter EX4 4QD, UK
Trans R Soc Trop Med Hyg 102:S111-6. 2008..It is not clear which of the small animal models of melioidosis most accurately reflect disease in humans...
- A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosisT Atkins
Defence Science and Technology Laboratory, Salisbury, Wiltshire SP4 OJQ, United Kingdom
Infect Immun 70:5290-4. 2002..Mice inoculated intraperitoneally with the auxotrophic mutant, 35 days prior to challenge, were protected against a challenge dose of 6,000 median lethal doses of wild-type B. pseudomallei...
- Passive protection against Burkholderia pseudomallei infection in mice by monoclonal antibodies against capsular polysaccharide, lipopolysaccharide or proteinsS M Jones
Microbiology, Dstl, CBS Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
J Med Microbiol 51:1055-62. 2002Burkholderia pseudomallei, the aetiological agent of melioidosis, is endemic in south-east Asia and northern Australia, where it is an important cause of human disease...
- Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosisAnna Easton
Centre for Clinical Microbiology, Royal Free Campus University College London, United Kingdom
J Infect Dis 204:636-44. 2011The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a major cause of lethal sepsis and morbidity in endemic areas of Southeast Asia and a potential bioterrorism threat...
- Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunizationWildaliz Nieves
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
PLoS ONE 5:e14361. 2010Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine against infection with this biological threat agent...
- Variations in ceftazidime and amoxicillin-clavulanate susceptibilities within a clonal infection of Burkholderia pseudomalleiI Ching Sam
Department of Medical Microbiology, Faculty of Medicine, Tropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, Malaysia
J Clin Microbiol 47:1556-8. 2009..Susceptibility testing of multiple colony variants from different sites should be performed for patients with culture-confirmed melioidosis.
- Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern AustraliaMirjam Kaestli
Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
PLoS Negl Trop Dis 3:e364. 2009The soil-dwelling saprophyte bacterium Burkholderia pseudomallei is the cause of melioidosis, a severe disease of humans and animals in southeast Asia and northern Australia. Despite the detection of B...
- Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glandersMitali Sarkar-Tyson
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK
Vaccine 27:4447-51. 2009Burkholderia pseudomallei and Burkholderia mallei are gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases...
- Distribution of melioidosis cases and viable Burkholderia pseudomallei in soil: evidence for emerging melioidosis in TaiwanYao Shen Chen
Division of Infectious Diseases, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
J Clin Microbiol 48:1432-4. 2010..in soil in Taiwan found that its incidence is comparable to that in other regions of the world where melioidosis is endemic...
- Emerging and re-emerging bacterial diseases in IndiaT D Chugh
Dr B L Kapur Memorial Hospital, 5, Pusa Road, New Delhi 110 005, India
J Biosci 33:549-55. 2008..This review of bacterial emerging and re-emerging diseases should be of critical importance to microbiologists,clinicians,public health personnel and policy makers in India...
- Role of quorum sensing in the pathogenicity of Burkholderia pseudomalleiRicky L Ulrich
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
J Med Microbiol 53:1053-64. 2004Burkholderia pseudomallei is the causative agent of human and animal melioidosis. The role of quorum sensing (QS) in the in vivo pathogenicity of B...
- Attempted passive prophylaxis with a monoclonal anti-Burkholderia pseudomallei exopolysaccharide antibody in a murine model of melioidosisChantal Bottex
Centre de Recherches du Service de Santé des Armées Emile Pardé, Unite de Microbiologie, La Tronche, France
Immunopharmacol Immunotoxicol 27:565-83. 2005b>Melioidosis is a severe gram-negative infection caused by the facultative intracellular bacterium Burkholderia pseudomallei, which is responsible for a broad spectrum of symptoms in both humans and animals...
- Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosisA J Simpson
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
J Infect Dis 181:621-5. 2000..IL-6, and IL-10) were performed on admission plasma samples from 172 adult Thai patients with severe melioidosis. Mortality was 31.4%...
- Towards a rapid molecular diagnostic for melioidosis: Comparison of DNA extraction methods from clinical specimensLeisha J Richardson
Menzies School of Health Research, Charles Darwin University, Darwin, Australia
J Microbiol Methods 88:179-81. 2012..from clinical samples for Burkholderia pseudomallei Type III secretion system real-time PCR in suspected melioidosis patients confirmed that urine and sputum are useful diagnostic samples...
- Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosisF N Lauw
Laboratory of Experimental Internal Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Infect Dis 180:1878-85. 1999..the plasma concentrations of IFN-gamma, IL-18, IL-12, and IL-15 were measured in 83 patients with suspected melioidosis. The diagnosis was confirmed in 62 patients, 31 of whom had blood cultures positive for Burkholderia ..
- Activation of Toll-like receptors by Burkholderia pseudomalleiT Eoin West
Department of Medicine, University of Washington, Seattle, Washington, USA
BMC Immunol 9:46. 2008b>Melioidosis, a lethal tropical infection that is endemic in southeast Asia and northern Australia, is caused by the saprophytic Gram-negative bacterium Burkholderia pseudomallei...
- Antimicrobial and antibiofilm activity of LL-37 and its truncated variants against Burkholderia pseudomalleiSakawrat Kanthawong
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Int J Antimicrob Agents 39:39-44. 2012The Gram-negative bacterium Burkholderia pseudomallei is the aetiological agent of melioidosis, which is an endemic disease in tropical areas of Southeast Asia and Northern Australia...
- Altered macrophage function is associated with severe Burkholderia pseudomallei infection in a murine model of type 2 diabetesKelly A Hodgson
Microbiology and Immunology, School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland 4811, Australia
Microbes Infect 13:1177-84. 2011..pseudomallei. Functional differences between macrophages of diabetic and non-diabetic mice toward B. pseudomallei may contribute to rapid dissemination and more severe disease progression in hosts with co-morbid type 2 diabetes...
- The role of NOD2 in murine and human melioidosisNicolle D Myers
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195
J Immunol 192:300-7. 2014..Burkholderia pseudomallei, a facultative intracellular bacterium, causes the tropical infection melioidosis. We hypothesized that NOD2 may participate in host defense in melioidosis...
- Neutrophils are the predominant cell-type to associate with Burkholderia pseudomallei in a BALB/c mouse model of respiratory melioidosisThomas R Laws
Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
Microb Pathog 51:471-5. 2011A variety of studies have implicated neutrophils and the rapid induction of cytokine in the host response in melioidosis. Here a BALB/c mouse model of infection with aerosolised Burkholderia pseudomallei K96243 has been used to ..
- Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesisJ Cuccui
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, United Kingdom
Infect Immun 75:1186-95. 2007Burkholderia pseudomallei, the causative agent of melioidosis, is an important human pathogen in Southeast Asia and northern Australia for which a vaccine is unavailable...
- A role of Burkholderia pseudomallei flagella as a virulent factorTippamas Chuaygud
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Trans R Soc Trop Med Hyg 102:S140-4. 2008Burkholderia pseudomallei is an agent of melioidosis and is closely related to avirulent B. thailandensis. Burkholderia thailandensis has a 15-bp deletion within the variable region of the flagellin gene fliC compared with B...
- Immunogenic Burkholderia pseudomallei outer membrane proteins as potential candidate vaccine targetsYuka Hara
Malaysia Genome Institute, UKM MTDC Smart Technology Centre, Bangi, Selangor, Malaysia
PLoS ONE 4:e6496. 2009Burkholderia pseudomallei is the causative agent of melioidosis, a disease of significant morbidity and mortality in both human and animals in endemic areas...
- Impaired TLR5 functionality is associated with survival in melioidosisT Eoin West
International Respiratory and Severe Illness Center, University of Washington, Seattle, WA 98104, USA
J Immunol 190:3373-9. 2013b>Melioidosis is infection caused by the flagellated saprophyte Burkholderia pseudomallei. TLR5 is a pathogen recognition receptor activated by bacterial flagellin...
- Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteriaKai Soo Tan
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
J Clin Invest 122:2289-300. 2012Individuals with type 2 diabetes are at increased risk of acquiring melioidosis, a disease caused by Burkholderia pseudomallei infection...
- Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glandersKay B Barnes
Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Int J Antimicrob Agents 41:552-7. 2013Burkholderia pseudomallei is the causative agent of the disease melioidosis, which is prevalent in tropical countries and is intractable to a number of antibiotics...
- Development of antibodies to Burkholderia pseudomallei during childhood in melioidosis-endemic northeast ThailandVanaporn Wuthiekanun
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 74:1074-5. 2006..There was a sharp rise in detectable antibodies from birth to 4 years followed by reactivity in approximately 60-70% of children thereafter...
- Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to miceT Eoin West
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
Am J Trop Med Hyg 83:1066-9. 2010b>Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei...
- Polysaccharide specific monoclonal antibodies provide passive protection against intranasal challenge with Burkholderia pseudomalleiDavid P AuCoin
Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, Nevada, United States of America
PLoS ONE 7:e35386. 2012Burkholderia pseudomallei is a Gram-negative bacillus that is the causative agent of melioidosis. The bacterium is inherently resistant to many antibiotics and mortality rates remain high in endemic areas...
- Clinical features and epidemiology of melioidosis pneumonia: results from a 21-year study and review of the literatureElla M Meumann
Infectious Diseases Department and Northern Territory Clinical School, Royal Darwin Hospital, Darwin, Australia
Clin Infect Dis 54:362-9. 2012b>Melioidosis is an important cause of community-acquired sepsis in Southeast Asia and northern Australia, and pneumonia is the most common presentation...
- Melioidosis and Aboriginal seasons in northern AustraliaAllen C Cheng
Department of Medicine, University of Melbourne, c o Victorian Infectious Diseases Service, 9th Floor, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia
Trans R Soc Trop Med Hyg 102:S26-9. 2008b>Melioidosis, an infection due to the environmental bacterium Burkholderia pseudomallei, is endemic to Southeast Asia and northern Australia, with cases strongly correlated with the monsoonal wet season...
- Evolution of Burkholderia pseudomallei in recurrent melioidosisHillary S Hayden
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 7:e36507. 2012Burkholderia pseudomallei, the etiologic agent of human melioidosis, is capable of causing severe acute infection with overwhelming septicemia leading to death...
- Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from AustraliaDerek S Sarovich
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
PLoS ONE 7:e30789. 2012Burkholderia pseudomallei is a gram-negative bacterium that causes the serious human disease, melioidosis. There is no vaccine against melioidosis and it can be fatal if not treated with a specific antibiotic regimen, which typically ..
- Development of an acute model of inhalational melioidosis in the common marmoset (Callithrix jacchus)Michelle Nelson
Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire, UK
Int J Exp Pathol 92:428-35. 2011Studies of inhalational melioidosis were undertaken in the common marmoset (Callithrix jacchus)...
- Analysis of peptide mimotopes of Burkholderia pseudomallei exopolysaccharideJoseph B Legutki
Department of Microbiology, The Ohio State University, 484 W 12th Ave Rm 376, Columbus, OH 43210, United States
Vaccine 25:7796-805. 2007..pseudomallei capsular exopolysaccharide. In a murine model of acute melioidosis, immunization with the mimotope of the 4VA5 binding site extended the mean time to death to 8...
- Survival of Burkholderia pseudomallei in distilled water for 16 yearsApinya Pumpuang
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Trans R Soc Trop Med Hyg 105:598-600. 2011..Pulsed-field gel electrophoresis analysis of AvrII DNA restriction fragments revealed six different but related banding patterns, which may represent genomic rearrangement...
- Effect of colony morphology variation of Burkholderia pseudomallei on intracellular survival and resistance to antimicrobial environments in human macrophages in vitroSarunporn Tandhavanant
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
BMC Microbiol 10:303. 2010Primary diagnostic cultures from patients with melioidosis demonstrate variation in colony morphology of the causative organism, Burkholderia pseudomallei...
- Growing Burkholderia pseudomallei in biofilm stimulating conditions significantly induces antimicrobial resistanceChakrit Sawasdidoln
Melioidosis Research Center, Khonkaen University, Khonkaen, Thailand
PLoS ONE 5:e9196. 2010Burkholderia pseudomallei, a gram-negative bacterium that causes melioidosis, was reported to produce biofilm...
- Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei InfectionsJerod A Skyberg
Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
PLoS Pathog 8:e1002587. 2012..tularensis and B. pseudomallei infections, suggesting this innate immune agonist has broad-spectrum activity against virulent intracellular pathogens...
- Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agentsChris Druar
Cangene Corporation, Mississauga, ON, Canada
FEMS Immunol Med Microbiol 52:78-87. 2008Burkholderia pseudomallei is a biothreat agent and an important natural pathogen, causing melioidosis in humans and animals. A type III secretion system (TTSS-3) has been shown to be critical for virulence...
- The genetic and molecular basis of O-antigenic diversity in Burkholderia pseudomallei lipopolysaccharideApichai Tuanyok
Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, USA
PLoS Negl Trop Dis 6:e1453. 2012..of the most important virulence and antigenic components of Burkholderia pseudomallei, the causative agent of melioidosis. LPS diversity in B...
- Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast ThailandVanaporn Wuthiekanun
Mahidol Oxford Tropical Medicine Research Unit, Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 55:5388-91. 2011..conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0...
- Melioidosis: advances in diagnosis and treatmentAllen C Cheng
Department of Epidemiology and Preventive Medicine, Monash University, Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
Curr Opin Infect Dis 23:554-9. 2010b>Melioidosis is an infectious disease caused by the soil-associated Gram-negative bacterium Burkholderia pseudomallei...
- Iron Uptake and Virulence of Burkholderia pseudomalleiJORGE CROSA; Fiscal Year: 2005b>Melioidosis and glanders are life threatening infectious diseases with similar patho-physiology caused respectively by the select agents Burkholderia pseudomallei and B. mallei, with dramatic repercussions in the field of bio-defense...
- Integrated Microfluidic Platform for Point-of-Care SerodiagnosticsXiaowu Liang; Fiscal Year: 2013..and a portable analyzer that can be driven by a mobile computing device for rapid serological evaluation of Melioidosis. By synergistically incorporating novel ALCAT-based approaches into these arrays we will have the versatility ..
- Target discovery and immunoassay for diagnosis of invasive aspergillosisThomas R Kozel; Fiscal Year: 2013..Proof of concept for the InMAD approach to target discovery is already in hand for tularemia, melioidosis and relapsing fever where candidate proteins and polysaccharides that are shed into serum during infection have ..
- Contact Dependent Growth Inhibition in Burkholderia pseudomalleiPeggy A Cotter; Fiscal Year: 2012..is a Gram-negative environmental saprotroph endemic to southeast Asia and northern Australia that causes melioidosis, a serious and often lethal human disease...
- Non-invasive Optical Imaging of Select Agent Bacteria in Non-human PrimatesFrederick D Quinn; Fiscal Year: 2010..pseudomallei (Bp) and Burkholderia mallei (Bm), the causative agents of human melioidosis and glanders...
- Pulmonary Pathogen-Recognition Pathways in MelioidosisTIMOTHY EOIN WEST; Fiscal Year: 2013..The second objective is to define pulmonary pathogen-recognition pathways in melioidosis, a lethal tropical infection caused by Burkholderia pseudomallei, a potential aerosol bioweapon. Dr...
- Regulation of host inflammatory responses and outcome in melioidosis by TLR5TIMOTHY EOIN WEST; Fiscal Year: 2013DESCRIPTION (provided by applicant): Melioidosis is an often lethal emerging infectious disease caused by the Gram-negative soil saprophyte and putative bioweapon, Burkholderia pseudomallei...
- World Melioidosis Congress 2010Herbert P Schweizer; Fiscal Year: 2010DESCRIPTION (provided by applicant): Melioidosis is a disease prevalent to tropical and subtropical regions of the world, with Northern Australia and SE Asia being highly endemic...
- Development and Formulation of Broad Spectrum Antimicrobials for BiodefenseRichard A Slayden; Fiscal Year: 2010..pseudomallei and the melioidosis animal model of infection and Y. pestis...
- Burkholderia: International Collaborative Development of Novel DiagnosticsPAUL STEPHEN KEIM; Fiscal Year: 2011..The etiological agent of melioidosis is rarely seen in US clinics but causes substantial morbidity and mortality in many areas of the world, ..
- Antigen Detection Assay for the Diagnosis of MelioidosisRaymond Houghton; Fiscal Year: 2013..provided by applicant): Burkholderia pseudomallei is a Gram-negative bacterium that is the causative agent of melioidosis. The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding...
- Novel Molecular Recognition Reagents for Detection of Pathogenic BurkholderiaKATHERINE ANNE BROWN; Fiscal Year: 2010..Burkholderia mallei (the causative agent of glanders) and Burkholderia pseudomallei (the causative agent of melioidosis)...
- DNA Fragment Capture System to Create Burkholderia pseudomallei isogenic StrainsBRIAN HOWARD KVITKO; Fiscal Year: 2012DESCRIPTION (provided by applicant): Burkholderia pseudomallei is the causative agent of melioidosis and a category B select agent for bioterrorism. Strains of B. pseudomallei display high levels of genomic diversity...
- Inter-Bacterial Competition Systems in Burkholderia pseudomalleiErin C Garcia; Fiscal Year: 2013DESCRIPTION (provided by applicant): Burkholderia pseudomallei, the causative agent of melioidosis and a potential bioterrorism threat, is intrinsically resistant to most commonly-prescribed antibiotics, demonstrating a clear ..
- Mechanisms of Ferritin-iron Acquisition and Burkholderia pseudomallei Infection.Herbert P Schweizer; Fiscal Year: 2013..The bacterium causes melioidosis, a disease comprising difficult-to-treat infections ranging from acute sepsis to long-lasting chronic ..
- Antibodies to Burkholderia type III secretion systemDon Stewart; Fiscal Year: 2005..These organisms cause life-threatening infections (Glanders' disease and Melioidosis, respectively), where antibiotic treatment is sometimes insufficient...
- Type IV Pilins as Vaccines against Bioterrorism ThreatsMichael Donnenberg; Fiscal Year: 2004..Burkholderia mallei and B. psuedomallei, the causative agents of glanders and melioidosis, respectively, represent significant biowarfare/bioterrorism threats...
- Burkholderia sp: Identification of major clonal lineagesJohn LiPuma; Fiscal Year: 2004..B. mallei and B. pseudomallei, the causative agents of glanders and melioidosis, respectively, have gained attention recently as agents of bioterrorism. Species within the B...
- Development of rapid detection tests for B pseudomalleiRaymond Houghton; Fiscal Year: 2006The Gram negative bacterium Burkholderia pseudomallei causes human melioidosis, a rapidly progressing and frequently fatal disease if not treated early...
- Task A49: Diabetic Mouse Models of MelioidosisTERI SAIA; Fiscal Year: 2013..This contract provides for the development and standardization of small animal models for infectious diseases, and may include efficacy testing of candidate therapeutic products. ..
- Regulation and function of Pseudomonas drug efflux pumpsHerbert Schweizer; Fiscal Year: 2006..Aim 3: Probe other, perhaps global regulators of efflux operon expression, specifically MexS and PA4878. ..
- PSEUDOMONAS AUTOINDUCER BIOSYNTHESIS AND DRUG DISCOVERYHerbert Schweizer; Fiscal Year: 2001..These studies should provide a better understanding of the quorum sensing pathways and lead to the identification of novel anti microbial targets and antimicrobials effective against gram-negative pathogens. ..
- Non-antiobiotic resistance markers for bacteriaHerbert Schweizer; Fiscal Year: 2006..pseudomallei, F. tularensis and Y. pestis, as well as other bacterial pathogens for which one faces similar restrictions regarding use of antibiotic selection markers for genetic manipulation. [unreadable] [unreadable] [unreadable]..
- Genetic Tools for Pathogenic BacteriaHerbert Schweizer; Fiscal Year: 2005....
- Intracellular Peptide Delivery ReagentPhilip Felgner; Fiscal Year: 2002..The understanding gained from this analysis will be applied to the design of peptides and reagent compositions to demonstrate functional intracellular peptide delivery. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- Generation of antigen specific regulatory T cellsChenthamarakshan Vasu; Fiscal Year: 2005..In aim-l, we will test the efficacy of BiAb in inducing regulatory T cells in vivo and in vitro. In aim-2, we will test the ability of these regulatory T cells in down modulating EAT and CIA. ..
- DNA METHYLATION-BASED BIOMARKERS OF UTI OUTCOMEJEFFREY JEDDELOH; Fiscal Year: 2005..By implementing the aims of this Phase I proposal, a new class of treatment altering microbial biomarker products will be enabled for marketing to the emerging molecular diagnostic markets ..
- Vaccinia Proteome Affinity Reagents From Phage DisplayPhilip Felgner; Fiscal Year: 2005..Successful "proof of concept" demonstrations in any of these assays will form the basis for a Phase II application leading, to arrays of analytical proteomics reagents against the other Class A, B & C bioterrorism agents. ..
- IgA inducing peptideD Estes; Fiscal Year: 2005..In addition, the proposed studies will begin to examine determine the potential relationship between IGIP and clinical abnormality in IgA production. ..
- Scanning B. pseudomallei proteome for vaccine antigensPhilip Felgner; Fiscal Year: 2008..pseudomallei in humans and experimental animals and will identify the most effective candidate antigens for development of a DNA or subunit vaccine against human melioidosis and glanders.
- Scanning the F. tularensis Proteome for Vaccine AntigensPhilip Felgner; Fiscal Year: 2006..tularensis infection, the responsive antigens identified by the Vaccine Antigen Scan will be candidates for use in a DNA or subunit vaccine. ..
- Adjuvants for Agile Vaccine DevelopmentPhilip Felgner; Fiscal Year: 2006..abstract_text> ..
- Scanning the P. falciparum proteome for vaccine antigensPhilip Felgner; Fiscal Year: 2006..abstract_text> ..
- Extracellular Proteins in Virulence of B. (pseudo)malleiMark Schell; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Microsphere based Tolerogenic antigen presentation systemChenthamarakshan Vasu; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..