melioidosis

Summary

Summary: A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.

Top Publications

  1. ncbi Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei
    W Joost Wiersinga
    Academic Medical Centre, Centre for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    Nat Rev Microbiol 4:272-82. 2006
  2. ncbi Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis
    Edouard E Galyov
    Department of Infection, Immunity and Inflammation, MSB, University of Leicester, Leicester LE1 9HN, United Kingdom
    Annu Rev Microbiol 64:495-517. 2010
  3. pmc The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study
    Bart J Currie
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Casuarina, Northern Territory, Australia
    PLoS Negl Trop Dis 4:e900. 2010
  4. pmc Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleterious
    Ivonne Ceballos-Olvera
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 7:e1002452. 2011
  5. pmc The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei
    Mary N Burtnick
    Department of Microbiology and Immunology, University of South Alabama, Mobile, Alabama 36688, USA
    Infect Immun 79:1512-25. 2011
  6. pmc Melioidosis: epidemiology, pathophysiology, and management
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Clin Microbiol Rev 18:383-416. 2005
  7. ncbi The global distribution of Burkholderia pseudomallei and melioidosis: an update
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Trans R Soc Trop Med Hyg 102:S1-4. 2008
  8. ncbi Melioidosis
    N J White
    Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand
    Lancet 361:1715-22. 2003
  9. pmc Increasing incidence of human melioidosis in Northeast Thailand
    Direk Limmathurotsakul
    Department of Tropical Hygiene and Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 82:1113-7. 2010
  10. pmc Toll-like receptor 4 region genetic variants are associated with susceptibility to melioidosis
    T E West
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Genes Immun 13:38-46. 2012

Detail Information

Publications275 found, 100 shown here

  1. ncbi Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei
    W Joost Wiersinga
    Academic Medical Centre, Centre for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    Nat Rev Microbiol 4:272-82. 2006
    Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia...
  2. ncbi Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis
    Edouard E Galyov
    Department of Infection, Immunity and Inflammation, MSB, University of Leicester, Leicester LE1 9HN, United Kingdom
    Annu Rev Microbiol 64:495-517. 2010
    ..knowledge on the specific virulence factors employed by these pathogens and their roles in the pathogenesis of melioidosis and glanders...
  3. pmc The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study
    Bart J Currie
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Casuarina, Northern Territory, Australia
    PLoS Negl Trop Dis 4:e900. 2010
    Over 20 years, from October 1989, the Darwin prospective melioidosis study has documented 540 cases from tropical Australia, providing new insights into epidemiology and the clinical spectrum.
  4. pmc Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleterious
    Ivonne Ceballos-Olvera
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 7:e1002452. 2011
    Burkholderia pseudomallei is a Gram-negative bacterium that infects macrophages and other cell types and causes melioidosis. The interaction of B...
  5. pmc The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei
    Mary N Burtnick
    Department of Microbiology and Immunology, University of South Alabama, Mobile, Alabama 36688, USA
    Infect Immun 79:1512-25. 2011
    ..recombinant Hcp proteins from each T6SS and tested them as vaccine candidates in the BALB/c mouse model of melioidosis. Recombinant Hcp2 protected 80% of mice against a lethal challenge with K96243, while recombinant Hcp1, Hcp3, ..
  6. pmc Melioidosis: epidemiology, pathophysiology, and management
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Clin Microbiol Rev 18:383-416. 2005
    b>Melioidosis, caused by the gram-negative saprophyte Burkholderia pseudomallei, is a disease of public health importance in southeast Asia and northern Australia that is associated with high case-fatality rates in animals and humans...
  7. ncbi The global distribution of Burkholderia pseudomallei and melioidosis: an update
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Trans R Soc Trop Med Hyg 102:S1-4. 2008
    While Southeast Asia and northern Australia are well recognized as the major endemic regions for melioidosis, recent reports have expanded the endemic zone...
  8. ncbi Melioidosis
    N J White
    Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand
    Lancet 361:1715-22. 2003
    b>Melioidosis, which is infection with the gram-negative bacterium Burkholderia pseudomallei, is an important cause of sepsis in east Asia and northern Australia...
  9. pmc Increasing incidence of human melioidosis in Northeast Thailand
    Direk Limmathurotsakul
    Department of Tropical Hygiene and Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 82:1113-7. 2010
    b>Melioidosis is a serious community-acquired infectious disease caused by the Gram-negative environmental bacterium Burkholderia pseudomallei...
  10. pmc Toll-like receptor 4 region genetic variants are associated with susceptibility to melioidosis
    T E West
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Genes Immun 13:38-46. 2012
    b>Melioidosis is a tropical infection caused by the Gram-negative soil saprophyte Burkholderia pseudomallei. Despite broad exposure of northeastern Thais, disease develops in only a small proportion of individuals...
  11. pmc Genome wide transcriptome profiling of a murine acute melioidosis model reveals new insights into how Burkholderia pseudomallei overcomes host innate immunity
    Chui Yoke Chin
    School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi Selangor D E Malaysia
    BMC Genomics 11:672. 2010
    ..pseudomallei) interacts with its host to elicit melioidosis symptoms...
  12. ncbi Melioidosis: a clinical overview
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Br Med Bull 99:125-39. 2011
    b>Melioidosis, an infection caused by the environmental Gram-negative bacillus Burkholderia pseudomallei, has emerged as an important cause of morbidity and mortality in Southeast Asia and northern Australia.
  13. pmc Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade
    Christopher T French
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:12095-100. 2011
    ..Our data suggest that the primary means for intercellular spread involves cell fusion, as opposed to pseudopod engulfment and bacterial escape from double-membrane vacuoles...
  14. pmc A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection
    Wildaliz Nieves
    Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
    Vaccine 29:8381-9. 2011
    ..pseudomallei that can be exploited for other intracellular respiratory pathogens, including other Burkholderia and bacteria capable of establishing persistent infection...
  15. pmc Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class models
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Mahidol University, Bangkok, Thailand
    PLoS ONE 5:e12485. 2010
    ....
  16. ncbi Rapid presumptive identification of Burkholderia pseudomallei with real-time PCR assays using fluorescent hybridization probes
    Herbert Tomaso
    Federal Armed Forces Institute of Microbiology, Neuherbergstrasse 11, Munich 80937, Germany
    Mol Cell Probes 19:9-20. 2005
    Burkholderia pseudomallei (the etiologic agent of melioidosis) can cause pyogenic or granulomatous lesions in almost any organ. Septicemia has a case fatality rate of >40%...
  17. pmc Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
    Rungnapa Pankla
    Department of Clinical Immunology, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, 123 Mittraparp Road, Khon Kaen, 40002, Thailand
    Genome Biol 10:R127. 2009
    b>Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, a Gram-negative bacillus classified by the National Institute of Allergy and Infectious Diseases (NIAID) as a category B priority agent...
  18. pmc Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
    Matthew T G Holden
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 101:14240-5. 2004
    Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world and accounts for 20% of community-..
  19. pmc Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis
    Gavin C K W Koh
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Clin Infect Dis 52:717-25. 2011
    ....
  20. pmc Persistent gastric colonization with Burkholderia pseudomallei and dissemination from the gastrointestinal tract following mucosal inoculation of mice
    Andrew Goodyear
    Department of Microbiology, Immunology, and Pathology, Rocky Mountain Regional Center for Excellence for Biodefense and Emerging Infectious Diseases Research, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 7:e37324. 2012
    b>Melioidosis is a disease of humans caused by opportunistic infection with the soil and water bacterium Burkholderia pseudomallei. Melioidosis can manifest as an acute, overwhelming infection or as a chronic, recurrent infection...
  21. ncbi Progress toward development of vaccines against melioidosis: A review
    Mitali Sarkar-Tyson
    Defence Science and Technology Laboratory, Salisbury, United Kingdom
    Clin Ther 32:1437-45. 2010
    b>Melioidosis is a serious and often fatal disease that is prevalent in subtropical and tropical climates, primarily in at-risk groups (eg, those with diabetes, alcoholism, or other cause of immunosuppression)...
  22. pmc Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei
    Narisara Chantratita
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Proc Natl Acad Sci U S A 108:17165-70. 2011
    ..a unique mechanism of β-lactam resistance in the biothreat organism Burkholderia pseudomallei (the cause of melioidosis), associated with treatment failure during prolonged ceftazidime therapy of natural infection...
  23. ncbi Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis
    Michelle Nelson
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 53:1177-82. 2004
    Burkholderia pseudomallei is the causative agent of melioidosis, which is a major cause of morbidity and mortality in endemic regions. Currently there is no human vaccine against melioidosis...
  24. ncbi An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen
    Mark P Stevens
    Division of Environmental Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, UK
    Mol Microbiol 46:649-59. 2002
    Burkholderia pseudomallei is the causative agent of melioidosis, a serious infectious disease of humans and animals that is endemic in subtropical areas. B...
  25. ncbi Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model
    Jonathan Warawa
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alta, Canada T2N 4N1
    FEMS Microbiol Lett 242:101-8. 2005
    Burkholderia pseudomallei, the etiological agent of melioidosis, is an animal pathogen capable of inducing a highly fatal septicemia. B...
  26. ncbi Immunization with the recombinant Burkholderia pseudomallei outer membrane protein Omp85 induces protective immunity in mice
    Yu Ching Su
    School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia
    Vaccine 28:5005-11. 2010
    Burkholderia pseudomallei is resistant to a wide range of antibiotics, leading to relapse and recrudescence of melioidosis after cessation of antibiotic therapy...
  27. pmc Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis
    Erin P Price
    Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America
    PLoS Pathog 6:e1000725. 2010
    ..Previous studies of Burkholderia pseudomallei, the etiologic agent of melioidosis, have shown that this opportunistic pathogen mutates rapidly both in vitro and in vivo at tandemly repeated ..
  28. pmc Caspase-1 mediates resistance in murine melioidosis
    Katrin Breitbach
    Friedrich Loeffler Institute of Medical Microbiology, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Infect Immun 77:1589-95. 2009
    The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical areas...
  29. ncbi A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei
    Anna Easton
    London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom
    J Infect Dis 195:99-107. 2007
    Inhalation is an important route of infection with Burkholderia pseudomallei, the causative agent of melioidosis. In resistant C57BL/6 mice, activated neutrophils are rapidly recruited to the lungs after intranasal B...
  30. pmc Biodefense-driven murine model of pneumonic melioidosis
    J A Jeddeloh
    Bacteriology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Infect Immun 71:584-7. 2003
    A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates...
  31. pmc Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    PLoS Med 4:e248. 2007
    ..b>Melioidosis is a severe infection caused by the gram-negative bacterium, Burkholderia pseudomallei, that is endemic in ..
  32. ncbi Indirect hemagglutination assay in patients with melioidosis in northern Australia
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 74:330-4. 2006
    b>Melioidosis is caused by the saprophytic organism Burkholderia pseudomallei. The use of the indirect hemagglutination assay (IHA) has found widespread use in areas endemic for this disease...
  33. pmc Low-dose exposure of C57BL/6 mice to burkholderia pseudomallei mimics chronic human melioidosis
    Laura Conejero
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Pathol 179:270-80. 2011
    Burkholderia pseudomallei is the etiological agent of human melioidosis, a disease with a broad spectrum of clinical manifestations ranging from fatal septicemia to chronic localized infection or asymptomatic latent infection...
  34. pmc Model of differential susceptibility to mucosal Burkholderia pseudomallei infection
    Boping Liu
    Department of Biochemistry Department of Microbiology, National University of Singapore, Singapore 119260
    Infect Immun 70:504-11. 2002
    Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with protean clinical manifestations...
  35. pmc Protection from pneumonic infection with burkholderia species by inhalational immunotherapy
    Andrew Goodyear
    Department of Microbiology, Immunology and Pathology, Colorado State University, Ft Collins, CO 80523, USA
    Infect Immun 77:1579-88. 2009
    Burkholderia mallei and B. pseudomallei are important human pathogens and cause the diseases glanders and melioidosis, respectively...
  36. ncbi Prospective clinical evaluation of the accuracy of 16S rRNA real-time PCR assay for the diagnosis of melioidosis
    Narisara Chantratita
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 77:814-7. 2007
    ..of a Burkholderia pseudomallei 16s rRNA real-time PCR assay was evaluated against culture for the diagnosis of melioidosis in Thailand. A total of 846 samples were obtained from 383 patients with suspected melioidosis...
  37. pmc Impaired early cytokine responses at the site of infection in a murine model of type 2 diabetes and melioidosis comorbidity
    Kelly A Hodgson
    Infectious Diseases and Immunopathogenesis Research Group, School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland, Australia
    Infect Immun 81:470-7. 2013
    Bacterial infections are a common and serious complication of type 2 diabetes (T2D). The prevalence of melioidosis, an emerging tropical infection caused by the Gram-negative bacterium Burkholderia pseudomallei, is increased in people ..
  38. ncbi Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosis
    Suzzanne J Owen
    Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
    J Infect Dis 199:1761-70. 2009
    Burkholderia pseudomallei, the causative agent of melioidosis, is generally considered to be acquired via inhalation of dust or water droplets from the environment...
  39. pmc Incidence, risk factors and clinical epidemiology of melioidosis: a complex socio-ecological emerging infectious disease in the Alor Setar region of Kedah, Malaysia
    Muhammad R A Hassan
    Imperial College London, London, UK
    BMC Infect Dis 10:302. 2010
    b>Melioidosis, a severe and fatal infectious disease caused by Burkholderia pseudomallei, is believed to an emerging global threat...
  40. ncbi Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis)
    L M Kager
    Center for Experimental and Molecular Medicine, Center for Infection and Immunity Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 9:2020-8. 2011
    b>Melioidosis is a frequent cause of sepsis in Southeast Asia caused by the Gram-negative bacterium Burkholderia pseudomallei...
  41. ncbi Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB/c and C57Bl/6 mice
    Gek Yen Gladys Tan
    Medical Countermeasures Laboratory, DSO National Laboratories, Singapore 117510
    J Med Microbiol 57:508-15. 2008
    b>Melioidosis is caused by the Gram-negative bacterium Burkholderia pseudomallei, whose portals of entry into the body include subcutaneous, ingestion and inhalation routes...
  42. ncbi Antibiotic susceptibility of Burkholderia pseudomallei from tropical northern Australia and implications for therapy of melioidosis
    A W Jenney
    Infectious Diseases Unit, Royal Darwin Hospital, Darwin, NT 0810, Australia
    Int J Antimicrob Agents 17:109-13. 2001
    From a prospective melioidosis study commencing in 1989 at Royal Darwin Hospital, 170 initial isolates of Burkholderia pseudomallei were available for susceptibility testing...
  43. pmc Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes
    Sharon J Peacock
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 6:e1488. 2012
    Burkholderia pseudomallei is a Category B select agent and the cause of melioidosis. Research funding for vaccine development has largely considered protection within the biothreat context, but the resulting vaccines could be applicable ..
  44. pmc Prevalence of melioidosis in the Er-Ren River Basin, Taiwan: implications for transmission
    Hsun Pi Su
    Centers for Disease Control, Department of Health Taiwan Institute of Veterinary Microbiology, National Chung Hsing University, Taichung, Taiwan
    J Clin Microbiol 45:2599-603. 2007
    An increase in melioidosis cases compared to other areas in Taiwan was observed in the Er-Ren River Basin, southwestern Taiwan, from November 2001 to August 2006...
  45. pmc A Burkholderia pseudomallei deltapurM mutant is avirulent in immunocompetent and immunodeficient animals: candidate strain for exclusion from select-agent lists
    Katie L Propst
    Department of Microbiology, Immunology and Pathology, Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Colorado State University, Fort Collins, Colorado 80523 2025, USA
    Infect Immun 78:3136-43. 2010
    Burkholderia pseudomallei causes the disease melioidosis in humans and is classified as a category B select agent...
  46. pmc In Vitro and In Vivo studies of monoclonal antibodies with prominent bactericidal activity against Burkholderia pseudomallei and Burkholderia mallei
    Shimin Zhang
    Department of Environmental and Infectious Disease Sciences, American Registry of Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Clin Vaccine Immunol 18:825-34. 2011
    ..The result is compatible with that of our in vitro study. The MAbs with the highest protective efficacy are those reactive to either the capsular PS or LPS of the Burkholderia bacteria...
  47. ncbi The epidemiology of melioidosis in Australia and Papua New Guinea
    B J Currie
    Division of Medicine, Royal Darwin Hospital Clinical School and Tropical Medicine and International Health Unit, Menzies School of Health Research, Casuarina, NT, Australia
    Acta Trop 74:121-7. 2000
    b>Melioidosis was first described in Australia in an outbreak in sheep in 1949 in north Queensland (22 degrees S). Human melioidosis was first described from Townsville (19 degrees S) in 1950...
  48. pmc The Burkholderia pseudomallei Δasd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice
    Michael H Norris
    Department of Microbiology, University of Hawaii at Manoa, Manoa, HI, 96822, USA
    Infect Immun 79:4010-8. 2011
    ..to be avirulent in BALB/c mice, and mice vaccinated with the mutant were protected against acute inhalation melioidosis. Thus, the B...
  49. ncbi Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis
    Sarah A Ngugi
    Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Vaccine 28:7551-5. 2010
    ..pseudomallei can provide protection against a lethal challenge of B. pseudomallei in a mouse model of melioidosis. Sugar analysis on LPS from B...
  50. ncbi Melioidosis in Malaysia
    S D Puthucheary
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Med J Malaysia 64:266-74. 2009
    b>Melioidosis is an important cause of sepsis in the tropics, is caused by an environmental saprophyte--B. pseudomallei. It affects mainly adults with underlying predisposing condition such as diabetes...
  51. ncbi Melioidosis in northern Australia, 2001-02
    Allen C Cheng
    Menzies School of Health Research, Darwin, Northern Territory
    Commun Dis Intell Q Rep 27:272-7. 2003
    b>Melioidosis, caused by the gram negative bacterium Burkholderia pseudomallei, is endemic in northern Australia...
  52. pmc Versatile dual-technology system for markerless allele replacement in Burkholderia pseudomallei
    Carolina M Lopez
    Department of Microbiology, Immunology and Pathology, Colorado State University, IDRC at Foothills Campus, Campus Delivery 2025, Fort Collins, CO 80523 2025, USA
    Appl Environ Microbiol 75:6496-503. 2009
    Burkholderia pseudomallei is the etiologic agent of melioidosis, a rare but serious tropical disease. In the United States, genetic research with this select agent bacterium is strictly regulated...
  53. pmc Cutaneous melioidosis in a man who was taken as a prisoner of war by the Japanese during World War II
    Viseth Ngauy
    Wiford Hall Medical Center, Lackland Air Force Base, San Antonio, USA
    J Clin Microbiol 43:970-2. 2005
    b>Melioidosis, an infection caused by the gram-negative bacillus Burkholderia pseudomallei, is endemic to Southeast Asia and Northern Australia...
  54. pmc Flagella are virulence determinants of Burkholderia pseudomallei
    K L Chua
    Department of Biochemistry, National University of Singapore, Faculty of Medicine, 10 Kent Ridge Crescent, Singapore 119260
    Infect Immun 71:1622-9. 2003
    ..intracellular pathogen, is a flagellated and motile gram-negative bacterium and is the causative agent of melioidosis in humans...
  55. pmc Intensity of rainfall and severity of melioidosis, Australia
    Bart J Currie
    Menzies School of Health Research and Flinders University, Darwin, Northern Territory, Australia
    Emerg Infect Dis 9:1538-42. 2003
    In a 12-year prospective study of 318 culture-confirmed cases of melioidosis from the Top End of the Northern Territory of Australia, rainfall data for individual patient locations were correlated with patient risk factors, clinical ..
  56. ncbi Management of melioidosis
    Vanaporn Wuthiekanun
    Mahidol University, Faculty of Tropical Medicine, Bangkok, Thailand
    Expert Rev Anti Infect Ther 4:445-55. 2006
    b>Melioidosis is a serious human infection caused by the environmental Gram-negative bacterium Burkholderia pseudomallei. Outcome following melioidosis remains poor despite 20 years of clinical research...
  57. pmc Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomallei
    Narisara Chantratita
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Bacteriol 189:807-17. 2007
    b>Melioidosis is a notoriously protracted illness and is difficult to cure...
  58. pmc Present and future therapeutic strategies for melioidosis and glanders
    D Mark Estes
    Department of Microbiology and Immunology, Department of Pathology and The Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Expert Rev Anti Infect Ther 8:325-38. 2010
    Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. Both Gram-negative pathogens are endemic in many parts of the world...
  59. ncbi Burkholderia pseudomallei: animal models of infection
    Richard W Titball
    School of Biosciences, Geoffrey Pope Building, University of Exeter, Exeter EX4 4QD, UK
    Trans R Soc Trop Med Hyg 102:S111-6. 2008
    ..It is not clear which of the small animal models of melioidosis most accurately reflect disease in humans...
  60. pmc A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis
    T Atkins
    Defence Science and Technology Laboratory, Salisbury, Wiltshire SP4 OJQ, United Kingdom
    Infect Immun 70:5290-4. 2002
    ..Mice inoculated intraperitoneally with the auxotrophic mutant, 35 days prior to challenge, were protected against a challenge dose of 6,000 median lethal doses of wild-type B. pseudomallei...
  61. ncbi Passive protection against Burkholderia pseudomallei infection in mice by monoclonal antibodies against capsular polysaccharide, lipopolysaccharide or proteins
    S M Jones
    Microbiology, Dstl, CBS Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 51:1055-62. 2002
    Burkholderia pseudomallei, the aetiological agent of melioidosis, is endemic in south-east Asia and northern Australia, where it is an important cause of human disease...
  62. pmc Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosis
    Anna Easton
    Centre for Clinical Microbiology, Royal Free Campus University College London, United Kingdom
    J Infect Dis 204:636-44. 2011
    The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a major cause of lethal sepsis and morbidity in endemic areas of Southeast Asia and a potential bioterrorism threat...
  63. pmc Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization
    Wildaliz Nieves
    Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
    PLoS ONE 5:e14361. 2010
    Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine against infection with this biological threat agent...
  64. pmc Variations in ceftazidime and amoxicillin-clavulanate susceptibilities within a clonal infection of Burkholderia pseudomallei
    I Ching Sam
    Department of Medical Microbiology, Faculty of Medicine, Tropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, Malaysia
    J Clin Microbiol 47:1556-8. 2009
    ..Susceptibility testing of multiple colony variants from different sites should be performed for patients with culture-confirmed melioidosis.
  65. pmc Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia
    Mirjam Kaestli
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Negl Trop Dis 3:e364. 2009
    The soil-dwelling saprophyte bacterium Burkholderia pseudomallei is the cause of melioidosis, a severe disease of humans and animals in southeast Asia and northern Australia. Despite the detection of B...
  66. ncbi Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders
    Mitali Sarkar-Tyson
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK
    Vaccine 27:4447-51. 2009
    Burkholderia pseudomallei and Burkholderia mallei are gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases...
  67. pmc Distribution of melioidosis cases and viable Burkholderia pseudomallei in soil: evidence for emerging melioidosis in Taiwan
    Yao Shen Chen
    Division of Infectious Diseases, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    J Clin Microbiol 48:1432-4. 2010
    ..in soil in Taiwan found that its incidence is comparable to that in other regions of the world where melioidosis is endemic...
  68. ncbi Emerging and re-emerging bacterial diseases in India
    T D Chugh
    Dr B L Kapur Memorial Hospital, 5, Pusa Road, New Delhi 110 005, India
    J Biosci 33:549-55. 2008
    ..This review of bacterial emerging and re-emerging diseases should be of critical importance to microbiologists,clinicians,public health personnel and policy makers in India...
  69. ncbi Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei
    Ricky L Ulrich
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    J Med Microbiol 53:1053-64. 2004
    Burkholderia pseudomallei is the causative agent of human and animal melioidosis. The role of quorum sensing (QS) in the in vivo pathogenicity of B...
  70. ncbi Attempted passive prophylaxis with a monoclonal anti-Burkholderia pseudomallei exopolysaccharide antibody in a murine model of melioidosis
    Chantal Bottex
    Centre de Recherches du Service de Santé des Armées Emile Pardé, Unite de Microbiologie, La Tronche, France
    Immunopharmacol Immunotoxicol 27:565-83. 2005
    b>Melioidosis is a severe gram-negative infection caused by the facultative intracellular bacterium Burkholderia pseudomallei, which is responsible for a broad spectrum of symptoms in both humans and animals...
  71. ncbi Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis
    A J Simpson
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Infect Dis 181:621-5. 2000
    ..IL-6, and IL-10) were performed on admission plasma samples from 172 adult Thai patients with severe melioidosis. Mortality was 31.4%...
  72. pmc Towards a rapid molecular diagnostic for melioidosis: Comparison of DNA extraction methods from clinical specimens
    Leisha J Richardson
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Microbiol Methods 88:179-81. 2012
    ..from clinical samples for Burkholderia pseudomallei Type III secretion system real-time PCR in suspected melioidosis patients confirmed that urine and sputum are useful diagnostic samples...
  73. ncbi Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
    F N Lauw
    Laboratory of Experimental Internal Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 180:1878-85. 1999
    ..the plasma concentrations of IFN-gamma, IL-18, IL-12, and IL-15 were measured in 83 patients with suspected melioidosis. The diagnosis was confirmed in 62 patients, 31 of whom had blood cultures positive for Burkholderia ..
  74. pmc Activation of Toll-like receptors by Burkholderia pseudomallei
    T Eoin West
    Department of Medicine, University of Washington, Seattle, Washington, USA
    BMC Immunol 9:46. 2008
    b>Melioidosis, a lethal tropical infection that is endemic in southeast Asia and northern Australia, is caused by the saprophytic Gram-negative bacterium Burkholderia pseudomallei...
  75. ncbi Antimicrobial and antibiofilm activity of LL-37 and its truncated variants against Burkholderia pseudomallei
    Sakawrat Kanthawong
    Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Antimicrob Agents 39:39-44. 2012
    The Gram-negative bacterium Burkholderia pseudomallei is the aetiological agent of melioidosis, which is an endemic disease in tropical areas of Southeast Asia and Northern Australia...
  76. ncbi Altered macrophage function is associated with severe Burkholderia pseudomallei infection in a murine model of type 2 diabetes
    Kelly A Hodgson
    Microbiology and Immunology, School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Microbes Infect 13:1177-84. 2011
    ..pseudomallei. Functional differences between macrophages of diabetic and non-diabetic mice toward B. pseudomallei may contribute to rapid dissemination and more severe disease progression in hosts with co-morbid type 2 diabetes...
  77. pmc The role of NOD2 in murine and human melioidosis
    Nicolle D Myers
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195
    J Immunol 192:300-7. 2014
    ..Burkholderia pseudomallei, a facultative intracellular bacterium, causes the tropical infection melioidosis. We hypothesized that NOD2 may participate in host defense in melioidosis...
  78. ncbi Neutrophils are the predominant cell-type to associate with Burkholderia pseudomallei in a BALB/c mouse model of respiratory melioidosis
    Thomas R Laws
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
    Microb Pathog 51:471-5. 2011
    A variety of studies have implicated neutrophils and the rapid induction of cytokine in the host response in melioidosis. Here a BALB/c mouse model of infection with aerosolised Burkholderia pseudomallei K96243 has been used to ..
  79. pmc Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis
    J Cuccui
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 75:1186-95. 2007
    Burkholderia pseudomallei, the causative agent of melioidosis, is an important human pathogen in Southeast Asia and northern Australia for which a vaccine is unavailable...
  80. ncbi A role of Burkholderia pseudomallei flagella as a virulent factor
    Tippamas Chuaygud
    Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 102:S140-4. 2008
    Burkholderia pseudomallei is an agent of melioidosis and is closely related to avirulent B. thailandensis. Burkholderia thailandensis has a 15-bp deletion within the variable region of the flagellin gene fliC compared with B...
  81. pmc Immunogenic Burkholderia pseudomallei outer membrane proteins as potential candidate vaccine targets
    Yuka Hara
    Malaysia Genome Institute, UKM MTDC Smart Technology Centre, Bangi, Selangor, Malaysia
    PLoS ONE 4:e6496. 2009
    Burkholderia pseudomallei is the causative agent of melioidosis, a disease of significant morbidity and mortality in both human and animals in endemic areas...
  82. pmc Impaired TLR5 functionality is associated with survival in melioidosis
    T Eoin West
    International Respiratory and Severe Illness Center, University of Washington, Seattle, WA 98104, USA
    J Immunol 190:3373-9. 2013
    b>Melioidosis is infection caused by the flagellated saprophyte Burkholderia pseudomallei. TLR5 is a pathogen recognition receptor activated by bacterial flagellin...
  83. pmc Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria
    Kai Soo Tan
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Clin Invest 122:2289-300. 2012
    Individuals with type 2 diabetes are at increased risk of acquiring melioidosis, a disease caused by Burkholderia pseudomallei infection...
  84. ncbi Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders
    Kay B Barnes
    Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Int J Antimicrob Agents 41:552-7. 2013
    Burkholderia pseudomallei is the causative agent of the disease melioidosis, which is prevalent in tropical countries and is intractable to a number of antibiotics...
  85. ncbi Development of antibodies to Burkholderia pseudomallei during childhood in melioidosis-endemic northeast Thailand
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 74:1074-5. 2006
    ..There was a sharp rise in detectable antibodies from birth to 4 years followed by reactivity in approximately 60-70% of children thereafter...
  86. pmc Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice
    T Eoin West
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Am J Trop Med Hyg 83:1066-9. 2010
    b>Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei...
  87. pmc Polysaccharide specific monoclonal antibodies provide passive protection against intranasal challenge with Burkholderia pseudomallei
    David P AuCoin
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, Nevada, United States of America
    PLoS ONE 7:e35386. 2012
    Burkholderia pseudomallei is a Gram-negative bacillus that is the causative agent of melioidosis. The bacterium is inherently resistant to many antibiotics and mortality rates remain high in endemic areas...
  88. pmc Clinical features and epidemiology of melioidosis pneumonia: results from a 21-year study and review of the literature
    Ella M Meumann
    Infectious Diseases Department and Northern Territory Clinical School, Royal Darwin Hospital, Darwin, Australia
    Clin Infect Dis 54:362-9. 2012
    b>Melioidosis is an important cause of community-acquired sepsis in Southeast Asia and northern Australia, and pneumonia is the most common presentation...
  89. ncbi Melioidosis and Aboriginal seasons in northern Australia
    Allen C Cheng
    Department of Medicine, University of Melbourne, c o Victorian Infectious Diseases Service, 9th Floor, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia
    Trans R Soc Trop Med Hyg 102:S26-9. 2008
    b>Melioidosis, an infection due to the environmental bacterium Burkholderia pseudomallei, is endemic to Southeast Asia and northern Australia, with cases strongly correlated with the monsoonal wet season...
  90. pmc Evolution of Burkholderia pseudomallei in recurrent melioidosis
    Hillary S Hayden
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e36507. 2012
    Burkholderia pseudomallei, the etiologic agent of human melioidosis, is capable of causing severe acute infection with overwhelming septicemia leading to death...
  91. pmc Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia
    Derek S Sarovich
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 7:e30789. 2012
    Burkholderia pseudomallei is a gram-negative bacterium that causes the serious human disease, melioidosis. There is no vaccine against melioidosis and it can be fatal if not treated with a specific antibiotic regimen, which typically ..
  92. pmc Development of an acute model of inhalational melioidosis in the common marmoset (Callithrix jacchus)
    Michelle Nelson
    Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire, UK
    Int J Exp Pathol 92:428-35. 2011
    Studies of inhalational melioidosis were undertaken in the common marmoset (Callithrix jacchus)...
  93. ncbi Analysis of peptide mimotopes of Burkholderia pseudomallei exopolysaccharide
    Joseph B Legutki
    Department of Microbiology, The Ohio State University, 484 W 12th Ave Rm 376, Columbus, OH 43210, United States
    Vaccine 25:7796-805. 2007
    ..pseudomallei capsular exopolysaccharide. In a murine model of acute melioidosis, immunization with the mimotope of the 4VA5 binding site extended the mean time to death to 8...
  94. pmc Survival of Burkholderia pseudomallei in distilled water for 16 years
    Apinya Pumpuang
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 105:598-600. 2011
    ..Pulsed-field gel electrophoresis analysis of AvrII DNA restriction fragments revealed six different but related banding patterns, which may represent genomic rearrangement...
  95. pmc Effect of colony morphology variation of Burkholderia pseudomallei on intracellular survival and resistance to antimicrobial environments in human macrophages in vitro
    Sarunporn Tandhavanant
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Microbiol 10:303. 2010
    Primary diagnostic cultures from patients with melioidosis demonstrate variation in colony morphology of the causative organism, Burkholderia pseudomallei...
  96. pmc Growing Burkholderia pseudomallei in biofilm stimulating conditions significantly induces antimicrobial resistance
    Chakrit Sawasdidoln
    Melioidosis Research Center, Khonkaen University, Khonkaen, Thailand
    PLoS ONE 5:e9196. 2010
    Burkholderia pseudomallei, a gram-negative bacterium that causes melioidosis, was reported to produce biofilm...
  97. pmc Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections
    Jerod A Skyberg
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    PLoS Pathog 8:e1002587. 2012
    ..tularensis and B. pseudomallei infections, suggesting this innate immune agonist has broad-spectrum activity against virulent intracellular pathogens...
  98. ncbi Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agents
    Chris Druar
    Cangene Corporation, Mississauga, ON, Canada
    FEMS Immunol Med Microbiol 52:78-87. 2008
    Burkholderia pseudomallei is a biothreat agent and an important natural pathogen, causing melioidosis in humans and animals. A type III secretion system (TTSS-3) has been shown to be critical for virulence...
  99. pmc The genetic and molecular basis of O-antigenic diversity in Burkholderia pseudomallei lipopolysaccharide
    Apichai Tuanyok
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 6:e1453. 2012
    ..of the most important virulence and antigenic components of Burkholderia pseudomallei, the causative agent of melioidosis. LPS diversity in B...
  100. pmc Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand
    Vanaporn Wuthiekanun
    Mahidol Oxford Tropical Medicine Research Unit, Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 55:5388-91. 2011
    ..conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0...
  101. ncbi Melioidosis: advances in diagnosis and treatment
    Allen C Cheng
    Department of Epidemiology and Preventive Medicine, Monash University, Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    Curr Opin Infect Dis 23:554-9. 2010
    b>Melioidosis is an infectious disease caused by the soil-associated Gram-negative bacterium Burkholderia pseudomallei...

Research Grants35

  1. Iron Uptake and Virulence of Burkholderia pseudomallei
    JORGE CROSA; Fiscal Year: 2005
    b>Melioidosis and glanders are life threatening infectious diseases with similar patho-physiology caused respectively by the select agents Burkholderia pseudomallei and B. mallei, with dramatic repercussions in the field of bio-defense...
  2. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..and a portable analyzer that can be driven by a mobile computing device for rapid serological evaluation of Melioidosis. By synergistically incorporating novel ALCAT-based approaches into these arrays we will have the versatility ..
  3. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    ..Proof of concept for the InMAD approach to target discovery is already in hand for tularemia, melioidosis and relapsing fever where candidate proteins and polysaccharides that are shed into serum during infection have ..
  4. Contact Dependent Growth Inhibition in Burkholderia pseudomallei
    Peggy A Cotter; Fiscal Year: 2012
    ..is a Gram-negative environmental saprotroph endemic to southeast Asia and northern Australia that causes melioidosis, a serious and often lethal human disease...
  5. Non-invasive Optical Imaging of Select Agent Bacteria in Non-human Primates
    Frederick D Quinn; Fiscal Year: 2010
    ..pseudomallei (Bp) and Burkholderia mallei (Bm), the causative agents of human melioidosis and glanders...
  6. Pulmonary Pathogen-Recognition Pathways in Melioidosis
    TIMOTHY EOIN WEST; Fiscal Year: 2013
    ..The second objective is to define pulmonary pathogen-recognition pathways in melioidosis, a lethal tropical infection caused by Burkholderia pseudomallei, a potential aerosol bioweapon. Dr...
  7. Regulation of host inflammatory responses and outcome in melioidosis by TLR5
    TIMOTHY EOIN WEST; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Melioidosis is an often lethal emerging infectious disease caused by the Gram-negative soil saprophyte and putative bioweapon, Burkholderia pseudomallei...
  8. World Melioidosis Congress 2010
    Herbert P Schweizer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Melioidosis is a disease prevalent to tropical and subtropical regions of the world, with Northern Australia and SE Asia being highly endemic...
  9. Development and Formulation of Broad Spectrum Antimicrobials for Biodefense
    Richard A Slayden; Fiscal Year: 2010
    ..pseudomallei and the melioidosis animal model of infection and Y. pestis...
  10. Burkholderia: International Collaborative Development of Novel Diagnostics
    PAUL STEPHEN KEIM; Fiscal Year: 2011
    ..The etiological agent of melioidosis is rarely seen in US clinics but causes substantial morbidity and mortality in many areas of the world, ..
  11. Antigen Detection Assay for the Diagnosis of Melioidosis
    Raymond Houghton; Fiscal Year: 2013
    ..provided by applicant): Burkholderia pseudomallei is a Gram-negative bacterium that is the causative agent of melioidosis. The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding...
  12. Novel Molecular Recognition Reagents for Detection of Pathogenic Burkholderia
    KATHERINE ANNE BROWN; Fiscal Year: 2010
    ..Burkholderia mallei (the causative agent of glanders) and Burkholderia pseudomallei (the causative agent of melioidosis)...
  13. DNA Fragment Capture System to Create Burkholderia pseudomallei isogenic Strains
    BRIAN HOWARD KVITKO; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Burkholderia pseudomallei is the causative agent of melioidosis and a category B select agent for bioterrorism. Strains of B. pseudomallei display high levels of genomic diversity...
  14. Inter-Bacterial Competition Systems in Burkholderia pseudomallei
    Erin C Garcia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Burkholderia pseudomallei, the causative agent of melioidosis and a potential bioterrorism threat, is intrinsically resistant to most commonly-prescribed antibiotics, demonstrating a clear ..
  15. Mechanisms of Ferritin-iron Acquisition and Burkholderia pseudomallei Infection.
    Herbert P Schweizer; Fiscal Year: 2013
    ..The bacterium causes melioidosis, a disease comprising difficult-to-treat infections ranging from acute sepsis to long-lasting chronic ..
  16. Antibodies to Burkholderia type III secretion system
    Don Stewart; Fiscal Year: 2005
    ..These organisms cause life-threatening infections (Glanders' disease and Melioidosis, respectively), where antibiotic treatment is sometimes insufficient...
  17. Type IV Pilins as Vaccines against Bioterrorism Threats
    Michael Donnenberg; Fiscal Year: 2004
    ..Burkholderia mallei and B. psuedomallei, the causative agents of glanders and melioidosis, respectively, represent significant biowarfare/bioterrorism threats...
  18. Burkholderia sp: Identification of major clonal lineages
    John LiPuma; Fiscal Year: 2004
    ..B. mallei and B. pseudomallei, the causative agents of glanders and melioidosis, respectively, have gained attention recently as agents of bioterrorism. Species within the B...
  19. Development of rapid detection tests for B pseudomallei
    Raymond Houghton; Fiscal Year: 2006
    The Gram negative bacterium Burkholderia pseudomallei causes human melioidosis, a rapidly progressing and frequently fatal disease if not treated early...
  20. Task A49: Diabetic Mouse Models of Melioidosis
    TERI SAIA; Fiscal Year: 2013
    ..This contract provides for the development and standardization of small animal models for infectious diseases, and may include efficacy testing of candidate therapeutic products. ..
  21. Regulation and function of Pseudomonas drug efflux pumps
    Herbert Schweizer; Fiscal Year: 2006
    ..Aim 3: Probe other, perhaps global regulators of efflux operon expression, specifically MexS and PA4878. ..
  22. PSEUDOMONAS AUTOINDUCER BIOSYNTHESIS AND DRUG DISCOVERY
    Herbert Schweizer; Fiscal Year: 2001
    ..These studies should provide a better understanding of the quorum sensing pathways and lead to the identification of novel anti microbial targets and antimicrobials effective against gram-negative pathogens. ..
  23. Non-antiobiotic resistance markers for bacteria
    Herbert Schweizer; Fiscal Year: 2006
    ..pseudomallei, F. tularensis and Y. pestis, as well as other bacterial pathogens for which one faces similar restrictions regarding use of antibiotic selection markers for genetic manipulation. [unreadable] [unreadable] [unreadable]..
  24. Genetic Tools for Pathogenic Bacteria
    Herbert Schweizer; Fiscal Year: 2005
    ....
  25. Intracellular Peptide Delivery Reagent
    Philip Felgner; Fiscal Year: 2002
    ..The understanding gained from this analysis will be applied to the design of peptides and reagent compositions to demonstrate functional intracellular peptide delivery. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  26. Generation of antigen specific regulatory T cells
    Chenthamarakshan Vasu; Fiscal Year: 2005
    ..In aim-l, we will test the efficacy of BiAb in inducing regulatory T cells in vivo and in vitro. In aim-2, we will test the ability of these regulatory T cells in down modulating EAT and CIA. ..
  27. DNA METHYLATION-BASED BIOMARKERS OF UTI OUTCOME
    JEFFREY JEDDELOH; Fiscal Year: 2005
    ..By implementing the aims of this Phase I proposal, a new class of treatment altering microbial biomarker products will be enabled for marketing to the emerging molecular diagnostic markets ..
  28. Vaccinia Proteome Affinity Reagents From Phage Display
    Philip Felgner; Fiscal Year: 2005
    ..Successful "proof of concept" demonstrations in any of these assays will form the basis for a Phase II application leading, to arrays of analytical proteomics reagents against the other Class A, B & C bioterrorism agents. ..
  29. IgA inducing peptide
    D Estes; Fiscal Year: 2005
    ..In addition, the proposed studies will begin to examine determine the potential relationship between IGIP and clinical abnormality in IgA production. ..
  30. Scanning B. pseudomallei proteome for vaccine antigens
    Philip Felgner; Fiscal Year: 2008
    ..pseudomallei in humans and experimental animals and will identify the most effective candidate antigens for development of a DNA or subunit vaccine against human melioidosis and glanders.
  31. Scanning the F. tularensis Proteome for Vaccine Antigens
    Philip Felgner; Fiscal Year: 2006
    ..tularensis infection, the responsive antigens identified by the Vaccine Antigen Scan will be candidates for use in a DNA or subunit vaccine. ..
  32. Adjuvants for Agile Vaccine Development
    Philip Felgner; Fiscal Year: 2006
    ..abstract_text> ..
  33. Scanning the P. falciparum proteome for vaccine antigens
    Philip Felgner; Fiscal Year: 2006
    ..abstract_text> ..
  34. Extracellular Proteins in Virulence of B. (pseudo)mallei
    Mark Schell; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  35. Microsphere based Tolerogenic antigen presentation system
    Chenthamarakshan Vasu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..