lepromatous leprosy

Summary

Summary: A chronic communicable infection which is a principal or polar form of LEPROSY. This disorder is caused by MYCOBACTERIUM LEPRAE and produces diffuse granulomatous skin lesions in the form of nodules, macules, or papules. The peripheral nerves are involved symmetrically and neural sequelae occur in the advanced stage.

Top Publications

  1. ncbi Active surveillance of leprosy contacts in country with low prevalence rate
    Masanori Kai
    Int J Lepr Other Mycobact Dis 72:50-3. 2004
  2. ncbi Lepromatous leprosy of histoid type
    S R Annigeri
    Department of Microbiology, Jawaharlal Nehru Medical College, Belgaum, Karnataka, India
    Indian J Med Microbiol 25:70-1. 2007
  3. doi The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico
    Anabell Alvarado-Navarro
    Centro de Investigacion en Inmunologia y Dermatologia, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
    Immunol Lett 118:148-51. 2008
  4. ncbi Comparative evaluation of immunotherapeutic efficacy of BCG and mw vaccines in patients of borderline lepromatous and lepromatous leprosy
    Tarun Narang
    Department of Dermatology, Venereology and Leprology and Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Lepr Other Mycobact Dis 73:105-14. 2005
  5. doi Induction of lepromin reactivity in cured lepromatous leprosy patients: impaired chemokine response dissociates protective immunity from delayed type hypersensitivity
    Dipendra K Mitra
    Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Microbes Infect 11:1122-30. 2009
  6. ncbi An in vitro model for the lepromatous leprosy granuloma: fate of Mycobacterium leprae from target macrophages after interaction with normal and activated effector macrophages
    Deanna A Hagge
    National Hansen s Disease Programs, Laboratory Research Branch, Louisiana State University School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    J Immunol 172:7771-9. 2004
  7. doi A new Mycobacterium species causing diffuse lepromatous leprosy
    Xiang Y Han
    Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 130:856-64. 2008
  8. ncbi A second case of multidrug-resistant Mycobacterium leprae isolated from a Japanese patient with relapsed lepromatous leprosy
    Masanori Matsuoka
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1, Aobacho, Higashimurayama, Tokyo, 189 0002, Japan
    Int J Lepr Other Mycobact Dis 71:240-3. 2003
  9. ncbi Near-nerve potential in lepromatous leprosy
    Wilson Marques
    Department of Neurology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Campus da USP, Ribeirao Preto, Sao Paulo 14049 900, Brazil
    Muscle Nerve 28:460-3. 2003
  10. ncbi Lepromatous leprosy: a review and case report
    Eduardo Chimenos Kustner
    Facultad de Odontologia, Universidad de Barcelona
    Med Oral Patol Oral Cir Bucal 11:E474-9. 2006

Detail Information

Publications189 found, 100 shown here

  1. ncbi Active surveillance of leprosy contacts in country with low prevalence rate
    Masanori Kai
    Int J Lepr Other Mycobact Dis 72:50-3. 2004
    ..leprae infection. Out of 34 leprosy patients undergoing treatment, 4 lepromatous leprosy patients were antibody positive, and 6.8 to 23...
  2. ncbi Lepromatous leprosy of histoid type
    S R Annigeri
    Department of Microbiology, Jawaharlal Nehru Medical College, Belgaum, Karnataka, India
    Indian J Med Microbiol 25:70-1. 2007
    Histoid leprosy is a variant of lepromatous leprosy, which develops as a result of resistance to dapsone monotherapy...
  3. doi The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico
    Anabell Alvarado-Navarro
    Centro de Investigacion en Inmunologia y Dermatologia, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
    Immunol Lett 118:148-51. 2008
    ..In this case-control study, we evaluated 44 patients with lepromatous leprosy (LL) and 51 healthy subjects (HS)...
  4. ncbi Comparative evaluation of immunotherapeutic efficacy of BCG and mw vaccines in patients of borderline lepromatous and lepromatous leprosy
    Tarun Narang
    Department of Dermatology, Venereology and Leprology and Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Lepr Other Mycobact Dis 73:105-14. 2005
    ..D.T. Aims and objectives. To evaluate the role of BCG and Mw vaccines in the immunotherapy of leprosy...
  5. doi Induction of lepromin reactivity in cured lepromatous leprosy patients: impaired chemokine response dissociates protective immunity from delayed type hypersensitivity
    Dipendra K Mitra
    Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Microbes Infect 11:1122-30. 2009
    ..investigate the immunological mechanisms relevant for their dissociation in a group of non-relapsing cured lepromatous leprosy (CLL) patients...
  6. ncbi An in vitro model for the lepromatous leprosy granuloma: fate of Mycobacterium leprae from target macrophages after interaction with normal and activated effector macrophages
    Deanna A Hagge
    National Hansen s Disease Programs, Laboratory Research Branch, Louisiana State University School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    J Immunol 172:7771-9. 2004
    The lepromatous leprosy granuloma is a dynamic entity requiring a steady influx of macrophages (Mphi) for its maintenance...
  7. doi A new Mycobacterium species causing diffuse lepromatous leprosy
    Xiang Y Han
    Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 130:856-64. 2008
    ..We discovered a new Mycobacterium species from 2 patients who died of diffuse lepromatous leprosy (DLL)...
  8. ncbi A second case of multidrug-resistant Mycobacterium leprae isolated from a Japanese patient with relapsed lepromatous leprosy
    Masanori Matsuoka
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1, Aobacho, Higashimurayama, Tokyo, 189 0002, Japan
    Int J Lepr Other Mycobact Dis 71:240-3. 2003
    ..The drug resistant profile of the isolated strain was confirmed by the mouse footpad method and the identification of mutations in genes previously shown to be associated with resistance to each drug was made...
  9. ncbi Near-nerve potential in lepromatous leprosy
    Wilson Marques
    Department of Neurology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Campus da USP, Ribeirao Preto, Sao Paulo 14049 900, Brazil
    Muscle Nerve 28:460-3. 2003
    ....
  10. ncbi Lepromatous leprosy: a review and case report
    Eduardo Chimenos Kustner
    Facultad de Odontologia, Universidad de Barcelona
    Med Oral Patol Oral Cir Bucal 11:E474-9. 2006
    ..The disease presents polar clinical forms (the multibacillary lepromatous leprosy and the paucibacillary tuberculoid leprosy), as well as other intermediate forms with hybrid ..
  11. ncbi American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the T-helper 1 cell response
    Pierre Delobel
    Department of Infectious and Tropical Diseases, Purpan University Hospital, Toulouse, France
    Clin Infect Dis 37:628-33. 2003
    ..We report an exceptional triple association of American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis in a man with no recognized immunodeficiency...
  12. ncbi Lepromatous leprosy masquerading as acute sarcoidosis: a case report and literature review
    Mrinal M Patnaik
    Department of Internal Medicine, University of Minnesota, USA
    Minn Med 91:30-3. 2008
    ..This article describes the diagnostic challenges presented by a Minnesota patient eventually found to have lepromatous leprosy. That challenge was compounded by the fact that the clinical scenario closely mimicked connective tissue/..
  13. ncbi The effect of antigen presenting cells on the cytokine profiles of stable and reactional lepromatous leprosy patients
    I Nath
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi
    Immunol Lett 75:69-76. 2000
    ..reverse transcriptase based PCR (RT-PCR) to measure cytokine expression in peripheral blood cells from lepromatous leprosy patients with stable disease and those suffering from erythema nodosum leprosum (ENL/Type II) reactions...
  14. doi SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy
    Ernesto Prado-Montes de Oca
    Guadalajara University, Guadalajara, Jalisco, Mexico
    Infect Genet Evol 9:617-25. 2009
    ..Analysis was done on borderline leprosy, lepromatous leprosy (L-lep) and indeterminate leprosy subgroups compared with healthy controls...
  15. ncbi Histopathological study of apparently normal oral mucosa in lepromatous leprosy
    Sangeeta Palaskar
    Department of Oral and Maxillo Facial Pathology, M M College of Dental Sciences and Research, Mullana, Ambala
    Indian J Dent Res 16:12-4. 2005
    In lepromatous leprosy, it may be postulated that apparently normal areas of skin are the probable sites of future extension of the pathological process and the events taking place in these site might represent the earlier stages of such ..
  16. ncbi Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea
    Seong Beom Lee
    Institute of Hansen s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, 137 701, Seoul, Korea
    Immunogenetics 55:177-81. 2003
    ..However, the association between mutations of the IL12RB1, IL12RB2, and IFNGR1 encoding genes and lepromatous leprosy has not been studied...
  17. doi Necrotic erythema nodosum leprosum as the first manifestation of borderline lepromatous leprosy
    Athanasia Tourlaki
    Arch Dermatol 144:818-20. 2008
  18. ncbi Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients
    T J Kang
    Institute of Hansen s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, 137 701, Seoul, South Korea
    FEMS Immunol Med Microbiol 31:53-8. 2001
    ..Ten subjects among the lepromatous leprosy (LL) patients had a band variant detected by single-stranded conformational polymorphism...
  19. ncbi [Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample]
    Jesús Salvador Velarde Félix
    Centro de Medicina Genómica, Hospital General de Culiacán Dr Bernardo J Gastélum, Culiacan, Sinaloa, Mexico
    Salud Publica Mex 51:59-61. 2009
    To establish the association of the vitamin D receptor gene TaqI polymorphism with lepromatous leprosy (LL) in individuals from Sinaloa, Mexico.
  20. ncbi Leprosy
    Stephen L Walker
    Clinical Research Unit, Department of Infectious and Tropical Diseases, School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Clin Dermatol 25:165-72. 2007
    ..It is important that dermatologists are aware of the neurologic as well as the skin manifestations of the condition so that nerve involvement can be identified and treated rapidly...
  21. ncbi Concomitant infection with pulmonary tuberculosis and lepromatous leprosy
    M A Srilakshmi
    J Assoc Physicians India 51:528-9. 2003
  22. ncbi Localized lepromatous leprosy presenting as a painful nodule in a muscle
    D M Thappa
    Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
    Indian J Lepr 74:237-42. 2002
    b>Lepromatous leprosy is a generalized disease usually presenting with numerous macules, papules, nodules or plaques involving wide areas of the skin...
  23. ncbi A fatal case of erythema necroticans
    S V Davis
    Department of Skin and STD, Kasturba Medical College, Manipal 576 119, Karnataka
    Indian J Lepr 74:145-9. 2002
    ..of leprosy patients are the same as in the general population, with the exception of renal damage in lepromatous leprosy. There is possible increased mortality from side-effects of antileprosy drugs, steroids, or other drugs ..
  24. ncbi Borderline lepromatous leprosy presenting as a single cutaneous plaque
    Katherine S Armour
    Department of Dermatology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Australas J Dermatol 46:181-3. 2005
    ..He was clearly in a reversal reaction (type 1), which slowly resolved with treatment of prednisone...
  25. ncbi Single lesion borderline lepromatous leprosy
    Bikash Ranjan Kar
    Department of Dermatology, Schieffelin Leprosy Research and Training Center, Karigiri, Vellore, South India
    Int J Lepr Other Mycobact Dis 72:45-7. 2004
    ..with a single lesion on the face which, on histopathological examination, was found to be borderline lepromatous leprosy. The importance of doing skin smears as a routine in all patients to differentiate Multibacillary from ..
  26. ncbi [Histopathologic findings for the research of acid-fast bacilli in erythema nodosum]
    M C Pires
    Hospital do Servidor Publico Estadual de Sao Paulo, Brasil
    Rev Saude Publica 30:536-41. 1996
    ..This search must be performed when during the routine histopathological exam of sections stained by hematoxilin-eosin the ENL histopathological characteristics delineated herein are observed...
  27. ncbi Localized lepromatous leprosy in household contact of multibacillary disease
    Tarun Narang
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Cutan Med Surg 12:139-41. 2008
    b>Lepromatous leprosy (LL) is a generalized disease, usually with numerous papules, nodules, or plaques containing abundant Mycobacterium leprae and affecting wide areas of the skin.
  28. ncbi Hypopyon in leprosy uveitis
    S Rathinam
    Department of Uvea, Aravind Eye Hospital, Madurai, India
    J Postgrad Med 53:46-7. 2007
  29. ncbi A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy
    Tranquilino T Fajardo
    Leonard Wood Memorial Center for Leprosy Research, Cebu City, The Philippines
    Am J Trop Med Hyg 74:457-61. 2006
    In 1982-1984 we conducted a six-month clinical trial in 50 previously untreated lepromatous leprosy patients randomly assigned to directly observed monotherapy with one of two thioamides, ethionamide or prothionamide, each given six ..
  30. doi Recovery of IFN-gamma levels in PBMCs from lepromatous leprosy patients through the synergistic actions of the cytokines IL-12 and IL-18
    Rocio Ivette Lopez Roa
    Centro de Investigacion en Inmunologia y Dermatologia, Instituto Dermatológico de Jalisco, Departamento de Fisiologia, CUCS, Universidad de Guadalajara, Mexico
    Int Immunopharmacol 8:1715-20. 2008
    ..A low level of IFN-gamma production in PBMC cultures from lepromatous leprosy patients (LL) has been previously reported by several groups...
  31. ncbi A 28-kDa protein from Mycobacterium leprae is a target of the human antibody response in lepromatous leprosy
    B J Cherayil
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142
    J Immunol 141:4370-5. 1988
    The gene for a 28-kDa Mycobacterium leprae protein Ag, a major target of antibodies from patients with lepromatous leprosy, was cloned from a lambda-gt11-M. leprae DNA expression library and sequenced...
  32. ncbi A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy
    Tae Jin Kang
    Institute of Hansen s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, The Republic of Korea
    Cytokine 20:56-62. 2002
    ..We previously reported the detection of TLR2 Arg677Trp mutation in lepromatous leprosy. Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative ..
  33. ncbi Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Immunol 170:3451-4. 2003
    ..and the significance of TLR2Arg(677)Trp, a recently discovered human polymorphism that is associated with lepromatous leprosy. In mice, TNF-alpha production in response to M...
  34. ncbi Associations between human leukocyte antigens and leprosy in the Turkish population
    M Kocak
    Kirikkale University, Medical Faculty, Department of Dermatology, Turkey
    Clin Exp Dermatol 27:235-9. 2002
    ..HLA-A null antigen was found to have weak expression in patients with leprosy. In conclusion, factors other than HLA-class I and class II antigens may have a more critical role in the pathophysiology of leprosy infection in man...
  35. ncbi Paranasal sinus computed tomography findings in patients treated for lepromatous leprosy
    A Kiris
    Department of Radiology, Faculty of Medicine, Firat University, Elazig, Turkey
    J Laryngol Otol 121:15-8. 2007
    Nasal and paranasal sinus involvement is common in lepromatous leprosy and is of considerable epidemiological significance...
  36. ncbi [Erythema nodosum leprosum case series report: clinical profile, immunological basis and treatment implemented in health services]
    Jackeline Gomes Guerra
    Departamento de Medicina Tropical e Dermatologia, Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Goiania, GO
    Rev Soc Bras Med Trop 37:384-90. 2004
    ..The results point out to the association between ENL and neuritis and the rare adoption of thalidomide as a solely medication in the health services...
  37. ncbi Epidemiological characteristics of leprosy reactions: 15 years experience from north India
    Bhushan Kumar
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Lepr Other Mycobact Dis 72:125-33. 2004
    ..3% had recurrent episodes which continued for up to 8 years after the start of treatment. Lepromatous leprosy, female gender, and high Bacterial Index (>/=3) were recognized as risk factors for developing ENL...
  38. ncbi An evaluation of clinical and histopathological status in paucibacillary leprosy patients after completion of fixed duration therapy
    D Mathew
    Department of Dermatology, Venereology and Leprosy, Father Muller Medical College, Kankanady, Mangalore 575 002, Karnataka
    Indian J Lepr 76:11-8. 2004
    ..In this study, resolution of granuloma and clinical activity after completion of MDT were assessed...
  39. ncbi Does thalidomide have a role in leprosy?
    C L Crawford
    Lancet 363:1911. 2004
  40. ncbi A rare variant of erythema nodosum leprosum: a case report
    Shriya Dave
    Department of Dermatology and STD, JIPMER, Pondicherry, India
    Dermatol Online J 9:11. 2003
    We report a patient with lepromatous leprosy who developed a rare variant of type-2 lepra reaction, characterized by pustular lesions, on switching from WHO multi drug therapy (MDT) to ofloxacin-aided MDT.
  41. ncbi Relapses in multibacillary patients treated with multi-drug therapy until smear negativity: findings after twenty years
    Gift Norman
    Department of Community Health, Schieffelin Leprosy Research and Training Center, Karigiri, Vellore, India
    Int J Lepr Other Mycobact Dis 72:1-7. 2004
    ..07 per 100 person years follow-up. Drug susceptibility tests done on one of the relapsed patients revealed drug sensitive organisms to all multi-drug therapy drugs...
  42. pmc High expression of myeloid-related proteins 8 and 14 characterizes an inflammatorily active but ineffective response of macrophages during leprosy
    Cord H Sunderkötter
    Institute of Experimental Dermatology, University of Munster, Munster, Germany
    Immunology 111:472-80. 2004
    ....
  43. ncbi Pattern of bacillary clearance in multibacillary leprosy patients with multidrug therapy
    A Kumar
    Department of Epidemiology and Biostatistics, Central JALMA Institute for Leprosy, Taj Ganj, Agra, U P, India 282001
    Acta Leprol 12:123-8. 2003
    ..Patients who had several episodes of ENL, took significantly longer time (63.7 months versus 53.5 months, p<0.0001) to become smear negative than those without ENL...
  44. ncbi [Pentoxifylline in the treatment of erythema nodosum leprosum: results of an open study]
    G Y de Carsalade
    Dispensaire de Mamoudzou, DASS de Mayotte, BP 104, 97600, Mamoudzou, Mayotte, France
    Acta Leprol 12:117-22. 2003
    ..Our results confirm the action of PTX if it is slowly tapered down (4 months seem sufficient) and not abruptly to avoid relapses. As it is safe use, PTX could constitute the first line of ENL attack treatment...
  45. ncbi Antibodies to diverse lipids in the serum of patients with clinically cured leprosy and tuberculosis
    O Rojas-Espinosa
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Mexico DF
    Acta Leprol 12:112-6. 2003
    ..leprae, M. tuberculosis and M. habana, in the serum of patients with clinically cured lepromatous leprosy (sixteen) or tuberculosis (sixteen), 8 to 12 months after arresting the corresponding multi-drug therapy (..
  46. ncbi [Histoid leprosy with erythema nodosum leprosum]
    Z Alioua
    Service de Dermatologie, hôpital militaire d instruction Mohammed V, Rabat, Maroc
    Acta Leprol 12:107-11. 2003
    Histoid leprosy is a particular variant of lepromatous leprosy presenting as cutaneous or subcutaneous nodular and/or plaque-like lesions arising form apparently normal skin...
  47. ncbi [Current guidelines for leprosy treatment]
    B Flageul
    Service de Dermatologie, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Bull Soc Pathol Exot 96:357-61. 2003
    ..Because of the high risk of neurological permanent damage, reversal reaction needs to be diagnosed and treated as soon as possible. Here in, the current antibacillary and antireactionnal treatments are being reviewed...
  48. ncbi Differential interferon- gamma production characterizes the cytokine responses to Leishmania and Mycobacterium leprae antigens in concomitant mucocutaneous leishmaniasis and lepromatous leprosy
    Denise S Matos
    Departamento de Imunologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
    Clin Infect Dis 40:e5-12. 2005
    ..Diffuse cutaneous leishmaniasis and lepromatous leprosy represent the anergic end of the spectrum, whereas mucocutaneous leishmaniasis and tuberculoid leprosy are ..
  49. ncbi A study of leprosy reactions in a tertiary hospital in Delhi
    Neelu Sharma
    Department of Dermatology and Sexually Transmitted Diseases, Lady Hardinge Medical College and S S K and K S C Hospitals, New Delhi, India
    J Dermatol 31:898-903. 2004
    ..The prevalence of deformities in patients with reaction was 25%, and was more common in females. Deformities were observed in 23.25% of the T1R patients and 28% of the T2R patients...
  50. ncbi A mutation at codon 516 in the rpoB gene of Mycobacterium leprae confers resistance to rifampin
    Liangfen Zhang
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Int J Lepr Other Mycobact Dis 72:468-72. 2004
    ..The isolate was obtained from a relapsed lepromatous leprosy patient...
  51. ncbi Clinical and histologic variations among thirty patients with Lucio's phenomenon and pure and primitive diffuse lepromatosis (Latapi's lepromatosis)
    Thomas H Rea
    Division of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Int J Lepr Other Mycobact Dis 73:169-88. 2005
    ..Criteria for the diagnosis of Latapi's lepromatosis, in the absence of Lucio's phenomenon, are also considered...
  52. ncbi Erythema nodosum leprosum and HIV infection: A therapeutic experience
    Nand Lal Sharma
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, India
    Int J Lepr Other Mycobact Dis 73:189-93. 2005
    ..Early institution of antiretroviral therapy appears to provide an edge in improving the therapeutic outcome for him. It also suggests a direct and more complex interplay of HIV and Mycobacterium leprae infection...
  53. ncbi Persister studies in leprosy patients after multi-drug treatment
    U D Gupta
    Central JALMA Institute for Leprosy and Other Mycobacterial Diseases ICMR, Tajganj, Agra 282001, India
    Int J Lepr Other Mycobact Dis 73:100-4. 2005
    ..D.T. group at the same time period, respectively, but not in M.D.T. + Minocycline + Ofloxacin group after one year. The overall percentage of persisters was 5.55% by MFP and 7.14% by ATP assay up to 3 years of treatment...
  54. ncbi Erythema nodosum leprosum necroticans in a child--an unusual manifestation
    Deepika Pandhi
    Department of Dermatology and STD, University College of Medical Sciences and Guru, Teg Bahadur Hospital, New Delhi 110095, India
    Int J Lepr Other Mycobact Dis 73:122-6. 2005
    ..The lesions resolved completely following multi-bacilliary multi-drug therapy for 12 months, non-steroidal anti-inflammatory drugs and corticosteroids...
  55. ncbi Double-blind trial of the efficacy of pentoxifylline vs thalidomide for the treatment of type II reaction in leprosy
    A M Sales
    Laboratório de Hanseníase, Fundacao Oswaldo Cruz, Avenida Brazil 4365, 21045 900 Rio de Janeiro, RJ, Brazil
    Braz J Med Biol Res 40:243-8. 2007
    ..Nevertheless, continuous treatment with pentoxifylline was effective in relieving the clinical signs of ENL, especially limb edema and systemic symptoms, in 62.5% of the patients...
  56. ncbi Clinicopathologic challenge
    Tamihiro Kawakami
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    Int J Dermatol 46:348-9. 2007
  57. ncbi Wade's histoid leprosy: three clinical presentations
    Susana B Pereyra
    Departments of Dermatology and Pathology, Hospital Cordoba, Cordoba, Argentina
    Int J Dermatol 46:944-6. 2007
    ..histologic, immunologic, and bacteriologic features of three adult male patients with this rare variant of lepromatous leprosy as the initial presentation of the disease, observed in the Dermatology Department of Hospital Córdoba, Có..
  58. ncbi [Polyarthritis and papular eruption revealing leprosy]
    M Meyer
    Service de Dermatologie, centre hospitalier d Argenteuil, 69, rue du Lieutenant Colonel Prudhon, 95100 Argenteuil, France
    Rev Med Interne 29:242-5. 2008
    ..We report the case of a 28 year-old woman from Mali, who was diagnosed with lepromatous borderline leprosy with reversal reaction occurring in the postpartum as she presented with polyarthritis and skin lesions...
  59. ncbi Azathioprine in controlling type 2 reactions in leprosy: a case report
    S P K Athreya
    The Leprosy Mission Hospital, Nand Nagari, Delhi, India
    Lepr Rev 78:290-2. 2007
  60. ncbi A drug-resistant leprosy case detected by DNA sequence analysis from a relapsed Mexican leprosy patient
    Rocio Ivette Lopez-Roa
    Centro de Investigacion en Inmunologia y Dermatologia, Dpto de Fisiología CUCS, Universidad de Guadalajara Instituto Dermatologico de Jalisco, Guadalajara, Jalisco, Mexico
    Rev Latinoam Microbiol 48:256-9. 2006
    A skin biopsy sample was obtained from a relapsed lepromatous leprosy patient from the central area of Mexico. Genes associated with resistance to anti-leprosy drugs were analyzed by DNA sequence assay...
  61. ncbi Treatment of leprosy: science or politics?
    Bernard Naafs
    Leiden University Medical Centre, Leiden, The Netherlands
    Trop Med Int Health 11:268-78. 2006
    ..To review the history of the treatment of leprosy and leprosy reactions after World War II...
  62. ncbi Primary involvement of penile skin in lepromatous leprosy
    A K Mukhopadhyay
    Pranab, Ismile near Dharmaraj Mandir, Asansol 713 303, West Bengal, India
    Indian J Lepr 77:317-21. 2005
    Skin lesions in lepromatous leprosy (LL) are usually multiple and widespread. Though the lesion may occur anywhere on the skin, male genitalia is rarely involved...
  63. ncbi Presence of Mycobacterium leprae in epidermal cells of lepromatous skin and its significance
    Jasmita Satapathy
    Department of Pathology, Schieffelin Leprosy Research and Training Centre, Karigiri, Vellore, India
    Indian J Dermatol Venereol Leprol 71:267-9. 2005
    A 49-year-old man with lepromatous leprosy treated with dapsone monotherapy for 12 years (1967 to 1979) reported in the hospital in 2003, with relapsed disease. A slit skin smear showed a bacteriological index of 4+...
  64. ncbi Deep vein thrombosis: a rare complication of thalidomide therapy in recurrent erythema nodosum leprosum
    Nand L Sharma
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla 171001 India
    Int J Lepr Other Mycobact Dis 72:483-5. 2004
    ..A case of deep-vein thrombosis is reported in a female patient with multibacillary leprosy who received pulses of dexamethasone and cyclophosphamide for recurrent ENL that had not responded to prednisone and thalidomide...
  65. ncbi The relapse rate in MB leprosy patients treated with 2-years of WHO-MDT is not low
    Robert H Gelber
    Int J Lepr Other Mycobact Dis 72:493-500. 2004
    ..Also, this group of patients might well benefit from an alternative antimicrobial regimen from the outset, as well as upon relapse...
  66. ncbi Lepromatous iridocyclitis
    Mehmet Citirik
    SSK Ankara Eye Hospital, Ankara, Turkey
    Ocul Immunol Inflamm 13:95-9. 2005
    ..Skin nodule biopsy, however, demonstrated multiple fragmented organisms within histiocytes, consistent with leprosy. The iridocyclitis resolved after treatment with dapsone, corticosteroids, and rifampin and her vision returned to 20/20...
  67. ncbi Concerns regarding in vitro and in vivo uses of thalidomide
    Azeb Tadesse
    Lepr Rev 76:94-6. 2005
  68. ncbi A randomized, double-blind, double-dummy, controlled dose comparison of thalidomide for treatment of erythema nodosum leprosum
    Laarni G Villahermosa
    Leonard Wood Memorial Center for Leprosy Research American Leprosy Foundation Cebu City, The Philippines
    Am J Trop Med Hyg 72:518-26. 2005
    ..Slower tapering from a higher initial thalidomide dose may improve clinical ENL responses, but high recurrence rates after discontinuation indicates further assessment is needed to identify better tapering regimens...
  69. ncbi Leprosy acquired by inoculation from a knee injury
    J W Brandsma
    Consultant Rehabilitation, International Nepal Fellowship, Green Pastures Hospital and Rehabilitation Centre, PO Box 5, Pokhara, Nepal
    Lepr Rev 76:175-9. 2005
    ..In the presentation and discussion, some relevant factors will be reviewed and discussed that may play a role in the transmission, susceptibility and clinical development of the disease...
  70. ncbi Reaction cases treated at the Regional Leprosy Training and Research Institute, Aska, Orissa: a retrospective analysis
    V Santaram
    Regional Leprosy Training and Research Institute, Aska 761110, Ganjam, Orissa
    Indian J Lepr 76:310-20. 2004
    ..Both types taken together, in half of the cases the first episode of reaction developed within 6 months of starting treatment. Multiple episodes were more common with ENL...
  71. ncbi No role for thalidomide in the treatment of leprosy
    Colin L Crawford
    J Infect Dis 193:1743-4; author reply 1744-5. 2006
  72. ncbi A recessive major gene controls the mitsuda reaction in a region endemic for leprosy
    Brigitte Ranque
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Universite de Paris Rene Descartes INSERM U 550, Faculte de Medecine Necker, Paris, France, European Union
    J Infect Dis 192:1475-82. 2005
    ..leprae. Like leprosy, the Mitsuda reaction is thought to be genetically controlled, but its mode of inheritance is unknown, although the role of the NRAMP1 gene has previously been reported...
  73. ncbi Effective treatment of erythema nodosum leprosum with thalidomide is associated with immune stimulation
    Patrick A J Haslett
    Rockefeller University, New York, New York, USA
    J Infect Dis 192:2045-53. 2005
    ..Hence, the therapeutic effect of thalidomide in ENL appears to be associated with transient immune stimulation, which suggests that the drug may promote an active immunoregulatory response...
  74. ncbi The functional state of the complement system in leprosy
    Gabriela I Gomes
    Laboratorio de Biologia do Reconhecer, Centro de Biociencias e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Rio de Janeiro, Brazil
    Am J Trop Med Hyg 78:605-10. 2008
    ..An association is likely between circulating immune complexes and MBL high serum levels for initiation of CS activation in patients with LL form of leprosy...
  75. ncbi A case study in Hansen's disease acquired after heart transplant
    Beatrice K Launius
    Department of Surgery, Heart Transplant Clinic, Louisiana State University Health Science Center, Shreveport, LA, USA
    Crit Care Nurs Q 27:87-91. 2004
    ..There are multiple forms of the disease ranging from the relatively benign to the progressive, malignant lepromatous leprosy. There is effective antimicrobial treatment available that is capable of curing the disease...
  76. ncbi Elevated platelet counts and thrombocytosis in erythema nodosum leprosum
    Thomas H Rea
    Division of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Int J Lepr Other Mycobact Dis 70:167-73. 2002
    ....
  77. ncbi Thalidomide in the treatment of leprosy
    Steve K Teo
    Celgene Corporation, 7 Powder Horn Drive, Warren, NJ 07059, USA
    Microbes Infect 4:1193-202. 2002
    ..Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s...
  78. ncbi The schizophrenic career of a "monster drug"
    C L Crawford
    Pediatrics 111:712. 2003
  79. ncbi Pulsed corticosteroid therapy in patients with chronic recurrent ENL: a pilot study
    Anita Girdhar
    Central JALMA Institute for Leprosy, Tajganj, Agra 282 001
    Indian J Lepr 74:233-6. 2002
    ....
  80. ncbi A comparative and combinatorial study on two serological assays for detection of Mycobacterium leprae infection
    O Parkash
    Central JALMA Institute for Leprosy, Taj Ganj, Agra-282001, Inde
    Acta Leprol 12:63-9. 2001
    ..leprae infection. As usual, both the tests were more sensitive to detect lepromatous leprosy patients than tuberculoid type of leprosy patients...
  81. ncbi [Immuno-allergic accidents with rifamipcin]
    B Flageul
    Service de Dermatologie du Pr Dubertret, , avenue Claude-Vellefaux, 75475 Paris, France
    Acta Leprol 12:71-8. 2001
    ..Anti-RMP antibodies were detected only in the first case. The pathogenic mechanisms and the clinico-biologic features are discussed...
  82. ncbi Viability and drug susceptibility testing of M. leprae using mouse footpad in 37 relapse cases of leprosy
    V P Shetty
    Foundation for Medical Research, 84 A, R G Thadani Marg, Worli, Mumbai 400 018
    Int J Lepr Other Mycobact Dis 71:210-7. 2003
    ..Also, in one case skin and nerve showed that discordance viz: M. leprae derived from skin were resistant to RFP, while those derived from nerve tested sensitive to all three drugs, indicating tissue related difference...
  83. ncbi Long-term culture of multibacillary leprosy macrophages isolated from skin lesions: a new model to study Mycobacterium leprae-human cell interaction
    D F Moura
    Leprosy Laboratory, Department of Mycobacteriosis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos 21040 360, Rio de Janeiro, Brazil
    Br J Dermatol 157:273-83. 2007
    ..The functional properties and activation pathways of macrophages isolated from patients with MB leprosy remain only partially understood...
  84. ncbi [Leprosy - An overview from a pediatric perspective]
    K Magdorf
    , , Berlin, Germany
    Klin Padiatr 213:266-70. 2001
    ..This was achieved by a better understanding of bacteriological and immunological mechanisms over the past decades, resulting in a decline of Leprosy's incidence...
  85. ncbi Histopathological study of apparently normal skin of patients with leprosy
    Mohammad A El-Darouti
    Dermatology Department, Faculty of Medicine, Cairo University, Egypt
    Int J Dermatol 45:292-6. 2006
    ..Several clinical and laboratory observations point to the possible microscopical affection of normal-looking skin in leprosy...
  86. ncbi Unexplained delayed nerve impairment in leprosy after treatment
    N R Rosenberg
    Department of Neurology, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Lepr Rev 74:357-65. 2003
    ..The aetiology for the neuropathy in the other group remains unclear and further investigations are needed to understand the pathogenesis before treatment recommendations can be given...
  87. doi Erythrocyte glutathione peroxidase, glutathione reductase activities and blood glutathione content in leprosy
    C V Balasubrahmanya Prasad
    Department of Biochemistry, Jawaharlal Nehru Medical College, Nehru Nagar, Belgaum 590 010, India
    J Infect 56:469-73. 2008
    ..The objective of the present study was to assess blood glutathione content and erythrocyte antioxidant enzyme activities of glutathione peroxidase and glutathione reductase in leprosy...
  88. ncbi Mycobacterium leprae and Mycobacterium lepraemurium infections in domestic and wild animals
    O Rojas-Espinosa
    Department of Immunology, National School of Biological Sciences, National Polytechnic Institute Carpio y Plan de Ayala, Colonia Santo Tomas, 11340 Mexico, DF, Mexico
    Rev Sci Tech 20:219-51. 2001
    ..host resistance, leprosy may present as a benign disease (tuberculoid leprosy) or as a malignant disease (lepromatous leprosy), with a spectrum of intermediate stages appearing between the two...
  89. ncbi Water soluble complexes of C14 and C16 fatty acids and alcohols in media for cultivation of leprosy-derived psychrophilic mycobacteria
    L Kato
    Catherine Booth Hospital, Montreal, Canada
    Int J Lepr Other Mycobact Dis 62:75-88. 1994
    ..provoke Mitsuda-type late skin reactions in tuberculoid, borderline and borderline-tuberculoid but not in lepromatous leprosy volunteers...
  90. ncbi Prognostic evaluation of cell mediated immunity in leprosy and correlation with clinicopathological status of leprosy patients
    M Aziz
    Department of Pathology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, U P
    Indian J Pathol Microbiol 39:5-12. 1996
    ..01):borderline lepromatous leprosy (BL), (p < 0.001) and lepromatous subpolar and polar types (LL); (p < 0...
  91. ncbi Mycobacterium leprae in neurons of the medulla oblongata and spinal cord in leprosy
    Thida Aung
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Neuropathol Exp Neurol 66:284-94. 2007
    ..Involvement of the CNS was explored in autopsy cases of clinically cured lepromatous leprosy (n = 67) and in non-leprosy cases (n = 15)...
  92. ncbi Immunotherapy of lepromin-negative borderline leprosy patients with low-dose Convit vaccine as an adjunct to multidrug therapy; a six-year follow-up study in Calcutta
    S Chaudhury
    School of Tropical Medicine, Calcutta, India
    Int J Lepr Other Mycobact Dis 65:56-62. 1997
    ..leprosy patients with low-dose Convit vaccine, is an extension of our earlier study on the treatment of lepromatous leprosy patients with low-dose Convit vaccine as an adjunct to multidrug therapy (MDT)...
  93. ncbi Light and ultrastructural study of sciatic nerve lesions induced using intraneural injection of viable Mycobacterium leprae in normal and immunosuppressed Swiss white mice
    Vanaja Prabhakar Shetty
    Foundation for Medical Research, 84 A R G Thadani Marg, Worli, Bombay 400 018, India
    Int J Lepr Other Mycobact Dis 70:25-33. 2002
    ..leprosy (BT), Whereas in TR mice, the macrophages showed foamy cytoplasmic changes depicting borderline lepromatous leprosy (BL)...
  94. ncbi Epidemiology of leprosy and response to treatment in Hong Kong
    C K Ho
    Cheung Sha Wan Dermatology Clinic, 3 F West Kowloon Health Centre, 303 Cheung Sha Wan Road, Kowloon, Hong Kong
    Hong Kong Med J 12:174-9. 2006
    ..To review the reported trend of leprosy in Hong Kong...
  95. ncbi Growth and development of children of mothers with leprosy and healthy controls
    M Elizabeth Duncan
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    Ethiop Med J 45:9-23. 2007
    ..In the pre-sulphone and early sulphone years children of leprous parents had been followed in a few prospective studies to observe the development of leprosy. No studies were made of the growth and development of these children...
  96. ncbi Serodiagnosis of Hansen's disease/leprosy by enzyme-linked immunosorbent assay using cord factor (trehalose 6,6'-dimycolate) as an antigen
    L Wang
    Department of Bacteriology, Osaka City University Medical School, Japan
    Nihon Hansenbyo Gakkai Zasshi 68:165-74. 1999
    ..Among the total, 34 patients were classified clinically into three types of the disease, lepromatous leprosy (LL), borderline lepromatous (BL) and borderline tuberculoid (BT)...
  97. ncbi Simultaneous erythema nodosum and erythema multiforme after local lidocaine injection
    Alma Angélica Rodríguez-Carreón
    Dermatology, General Hospital Dr Manuel Gea Gonzalez, Mexico City, Mexico
    Ann Pharmacother 42:127-30. 2008
    ..To report a case of simultaneous erythema nodosum and erythema multiforme after local lidocaine injection...
  98. ncbi Analysis of newly detected leprosy cases and misdiagnosis in Wuhan (1990-2004)
    Daozhong Liu
    Wuhan Institute of Dermatology and Venereology, Hubei Province, China 430030
    Lepr Rev 80:410-5. 2009
    ..To analyse the leprosy epidemiological trends and the diagnostic delay in newly detected cases between 1990 and 2004 in Wuhan...
  99. doi Modified fine-needle aspiration technique for diagnosis of granulomatous skin lesions with special reference to leprosy and cutaneous tuberculosis
    Ghazala Mehdi
    Department of Pathology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
    Diagn Cytopathol 38:391-6. 2010
    ..The smears showed good cellularity. A broad division into tuberculoid and lepromatous leprosy could be made fairly accurately on cytology...
  100. doi Detection of RNA expression from pseudogenes and non-coding genomic regions of Mycobacterium leprae
    Kazuaki Nakamura
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Aoba cho, Higashimurayama, Tokyo, Japan
    Microb Pathog 47:183-7. 2009
    ..leprae from skin smear specimens obtained from patients with lepromatous leprosy by RT-PCR...
  101. pmc Ancient skeletal evidence for leprosy in India (2000 B.C.)
    Gwen Robbins
    Department of Anthropology, Appalachian State University, Boone, North Carolina, United States of America
    PLoS ONE 4:e5669. 2009
    ..leprae evolved either in East Africa or South Asia during the Late Pleistocene before spreading to Europe and the rest of the World. The earliest widely accepted evidence for leprosy is in Asian texts dated to 600 B.C...

Research Grants81

  1. Leukocyte Immunoglobulin-like Receptors in Cutaneous Host Defense
    DELPHINE LEE; Fiscal Year: 2007
    ..The insights gained from the study of LILRs, found at increased levels in lepromatous leprosy, will help broaden our understanding of immunoregulation of the innate and adaptive immune systems and may ..
  2. CD1-RESTRICTED T-CELL RESPONSES IN SKIN
    Robert Modlin; Fiscal Year: 2004
    ..by human CD1 molecules will be elucidated by deriving CD1-restricted T cells from both tuberculoid and lepromatous leprosy lesions...
  3. CD1-RESTRICTED T CELLS AGAINST THE TULAREMIA PATHOGEN
    PETER SIELING; Fiscal Year: 2005
    ..From these studies we hope to expand the diversity of lipid antigens known to activate CDl-restricted T cells with the future goal to design lipid-based vaccines against tularemia infection. ..
  4. Development & Manufacture of an MDR Tuberculosis Vaccine
    Steven Reed; Fiscal Year: 2005
    ..This will enable us to immediately proceed to human clinical trials after the end of the funding period. ..
  5. LEISHMANIA ANTIGENS DEFINED BY HUMAN IMMUNE RESPONSES
    Steven Reed; Fiscal Year: 2000
    ..The results obtained from these experiments will have direct impact on the protocols of vaccine development for humans and potentially for the diagnosis of leishmaniasis. ..
  6. Human T Cell Antigens of Mycobacterium tuberculosis
    Steven Reed; Fiscal Year: 2009
    ..Finally, we will test antigens/vaccine formulations in rodent models of infection and disease. By the end of the funding period, we will have defined a second vaccine candidate for entry into clinical trials. ..
  7. LEISHMANIA ANTIGENS DEFINED BY HUMAN IMMUNE RESPONSES
    Steven Reed; Fiscal Year: 2007
    ..donovani complex, and using new adjuvants, DNA immunization, or combinations (i.e. prime boost protocols) to develop an effective vaccine for humans and dogs. ..
  8. CD1 RESTRICTED T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS
    PETER SIELING; Fiscal Year: 2003
    ..Finally, we anticipate that our findings will be useful in establishing new mains of treating autoimmune disease. ..
  9. HUMAN T CELLS ANTIGENS OF MYCOBACTERIUM TUBERCULOSIS
    Steven Reed; Fiscal Year: 2003
    ..In addition, we will emphasize the use of human T cell expression cloning to identify other vaccine candidate antigens. These will be characterized in the in vitro and animal models as above. ..
  10. PHARMACOLOGIC T CELL COSTIMULATION IN HIV DISEASE
    Patrick Haslett; Fiscal Year: 2005
    ..If the results support the study hypothesis, a new approach to immune-based therapy for HIV disease will be suggested, as well as a rationale for clinical applications of an oral immune adjuvant drug. ..