leprosy

Summary

Summary: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.

Top Publications

  1. ncbi The biology of nerve injury in leprosy
    David M Scollard
    National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr Baton Rouge, LA 70803, USA
    Lepr Rev 79:242-53. 2008
  2. pmc The continuing challenges of leprosy
    D M Scollard
    Laboratory Research Branch, National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr, Baton Rouge, LA 70803, USA
    Clin Microbiol Rev 19:338-81. 2006
  3. ncbi Comparative genomic and phylogeographic analysis of Mycobacterium leprae
    Marc Monot
    Institut Pasteur, Paris, France
    Nat Genet 41:1282-9. 2009
  4. ncbi Leprosy now: epidemiology, progress, challenges, and research gaps
    Laura C Rodrigues
    Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Infect Dis 11:464-70. 2011
  5. pmc MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy
    Philip T Liu
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California, USA
    Nat Med 18:267-73. 2012
  6. doi Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy
    Furen Zhang
    Shandong Provincial Institute of Dermatology and Venereology, Provincial Academy of Medical Science, Jinan, China
    Nat Genet 43:1247-51. 2011
  7. ncbi Susceptibility to leprosy is associated with PARK2 and PACRG
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
    Nature 427:636-40. 2004
  8. pmc Probable zoonotic leprosy in the southern United States
    Richard W Truman
    Bureau of Primary Health Care, Health Resources and Services Administration, Department of Health and Human Services, National Hansen s Disease Program, Louisiana State University, Baton Rouge, USA
    N Engl J Med 364:1626-33. 2011
  9. doi IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians
    C C Cardoso
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, FIOCRUZ, Av Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040 360, Brazil
    Hum Genet 128:481-90. 2010
  10. pmc Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Infect Dis 197:253-61. 2008

Detail Information

Publications325 found, 100 shown here

  1. ncbi The biology of nerve injury in leprosy
    David M Scollard
    National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr Baton Rouge, LA 70803, USA
    Lepr Rev 79:242-53. 2008
    The steps in the pathogenesis of nerve injury in leprosy are depicted in Figure 1. Localisation of M. leprae to nerve, Schwann cell infection & responses, as yet unknown mechanisms of injury, axonal atrophy, and finally demyelination...
  2. pmc The continuing challenges of leprosy
    D M Scollard
    Laboratory Research Branch, National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr, Baton Rouge, LA 70803, USA
    Clin Microbiol Rev 19:338-81. 2006
    b>Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans...
  3. ncbi Comparative genomic and phylogeographic analysis of Mycobacterium leprae
    Marc Monot
    Institut Pasteur, Paris, France
    Nat Genet 41:1282-9. 2009
    ..31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M...
  4. ncbi Leprosy now: epidemiology, progress, challenges, and research gaps
    Laura C Rodrigues
    Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Infect Dis 11:464-70. 2011
    b>Leprosy continues to be a challenge to health worldwide, with about 250,000 new cases being detected every year. Despite widespread implementation of effective multidrug therapy, leprosy has not been eliminated...
  5. pmc MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy
    Philip T Liu
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California, USA
    Nat Med 18:267-73. 2012
    b>Leprosy provides a model to investigate mechanisms of immune regulation in humans, given that the disease forms a spectrum of clinical presentations that correlate with host immune responses...
  6. doi Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy
    Furen Zhang
    Shandong Provincial Institute of Dermatology and Venereology, Provincial Academy of Medical Science, Jinan, China
    Nat Genet 43:1247-51. 2011
    We performed a genome-wide association study with 706 individuals with leprosy and 5,581 control individuals and replicated the top 24 SNPs in three independent replication samples, including a total of 3,301 individuals with leprosy and ..
  7. ncbi Susceptibility to leprosy is associated with PARK2 and PACRG
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
    Nature 427:636-40. 2004
    b>Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year...
  8. pmc Probable zoonotic leprosy in the southern United States
    Richard W Truman
    Bureau of Primary Health Care, Health Resources and Services Administration, Department of Health and Human Services, National Hansen s Disease Program, Louisiana State University, Baton Rouge, USA
    N Engl J Med 364:1626-33. 2011
    In the southern region of the United States, such as in Louisiana and Texas, there are autochthonous cases of leprosy among native-born Americans with no history of foreign exposure...
  9. doi IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians
    C C Cardoso
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, FIOCRUZ, Av Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040 360, Brazil
    Hum Genet 128:481-90. 2010
    b>Leprosy is a chronic infectious disease caused by Mycobacterium leprae, a low virulence mycobacterium, and the outcome of disease is dependent on the host genetics for either susceptibility per se or severity...
  10. pmc Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Infect Dis 197:253-61. 2008
    b>Leprosy is characterized by a spectrum of clinical manifestations that depend on the type of immune response against the pathogen...
  11. ncbi Measuring leprosy stigma--a preliminary review of the leprosy literature
    Wim H van Brakel
    TLM Research Resource Center, 5 Amrita Shergill Marg, New Delhi 110003, India
    Int J Lepr Other Mycobact Dis 71:190-7. 2003
    A literature review was conducted to review work done to date on measuring stigma related to leprosy. References were obtained through a PubMed (Medline) search and through examining relevant bibliographies...
  12. ncbi Gender and leprosy: case studies in Indonesia, Nigeria, Nepal and Brazil
    Corlien M Varkevisser
    Royal Tropical Institute, Amsterdam, The Netherlands
    Lepr Rev 80:65-76. 2009
    There appear to be regional differences in gender ratios of leprosy patients being diagnosed and treated. In Asian countries, more men than women are registered whilst in Africa female patients outnumber males...
  13. doi Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
    Katherine A Mattos
    Laboratórios de Microbiologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    J Leukoc Biol 87:371-84. 2010
    ..However, the origin and nature of these lipids, as well as their function and contribution to leprosy disease, remain unclear...
  14. ncbi Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy
    Iara de Messias-Reason
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Germany
    J Infect Dis 199:801-4. 2009
    Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule...
  15. pmc Divergence of macrophage phagocytic and antimicrobial programs in leprosy
    Dennis Montoya
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Host Microbe 6:343-53. 2009
    ..The differential regulation of macrophage functional programs was confirmed by analysis of leprosy lesions: the macrophage phagocytosis pathway was prominent in the clinically progressive, multibacillary form of ..
  16. ncbi Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea
    Eun Young You
    Department of Emergency, Boramae Hospital, Seoul National University, 395 Shindaebang 2 dong, Dongjak Gu, Seoul 156 707, South Korea
    J Infect 50:6-11. 2005
    ..Identification of the presence and drug resistance of Mycobacterium leprae is key to the diagnosis and treatment of leprosy in non-endemic country like Korea...
  17. pmc Integrated pathways for neutrophil recruitment and inflammation in leprosy
    Delphine J Lee
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Infect Dis 201:558-69. 2010
    ..disease by means of bioinformatic pathways analysis of the gene expression profiles in the skin lesions of leprosy. In erythema nodosum leprosum (ENL), which occurs in patients with lepromatous leprosy and is characterized by ..
  18. ncbi The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10
    Ana Carolina F Motta
    Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 21:158-64. 2010
    The aim of this study was to determine whether the presence of leprosy reactional episodes could be associated with chronic oral infection...
  19. ncbi Risk factors for developing leprosy--a population-based cohort study in Indonesia
    Mirjam I Bakker
    KIT Koninklijk Instituut voor de Tropen Royal Tropical Institute, KIT Biomedical Research, Amsterdam, The Netherlands
    Lepr Rev 77:48-61. 2006
    We identified risk factors associated with increased yearly incidence rates of leprosy in five island populations. Age, sex, household size and Mycobacterium leprae-specific antibodies as well as contact factors were studied...
  20. ncbi Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility
    A C Pereira
    Instituto Lauro de Souza Lima, Bauru, Sao Paulo, Brazil
    Genes Immun 10:174-80. 2009
    b>Leprosy is a complex infectious disease influenced by genetic and environmental factors...
  21. pmc Prospective study of serological conversion as a risk factor for development of leprosy among household contacts
    J T Douglas
    Department of Microbiology, University of Hawaii, Honolulu, HI 96822, USA
    Clin Diagn Lab Immunol 11:897-900. 2004
    Although the prevalence of leprosy has declined over the years, there is no evidence that incidence rates are falling...
  22. doi TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study
    Cynthia C Cardoso
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
    J Infect Dis 204:1256-63. 2011
    b>Leprosy is an infectious disease caused by Mycobacterium leprae. Tumor necrosis factor (TNF) plays a key role in the host response...
  23. doi Association of variants in BAT1-LTA-TNF-BTNL2 genes within 6p21.3 region show graded risk to leprosy in unrelated cohorts of Indian population
    Shafat Ali
    National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Hum Genet 131:703-16. 2012
    ..Nine SNPs located in BAT1, LTA, TNF genes and BTNL2-DRA interval showed strong association with leprosy susceptibility in two independent sets of North Indian population which was replicated in a geographically ..
  24. ncbi Corticosteroids for treating nerve damage in leprosy. A Cochrane review
    Natasja H J Van Veen
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Lepr Rev 79:361-71. 2008
    Corticosteroids are commonly used for treating nerve damage in leprosy. We assessed the effectiveness of corticosteroids for treating nerve damage due to leprosy.
  25. pmc A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment
    Stephen L Walker
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1041. 2011
    b>Leprosy Type 1 reactions are a major cause of nerve damage and the preventable disability that results. Type 1 reactions are treated with oral corticosteroids and there are few data to support the optimal dose and duration of treatment...
  26. ncbi The impact of leprosy on health-related quality of life
    Anselmo Alves Lustosa
    Universidade Federal do Piaui, Teresina, Brazil
    Rev Soc Bras Med Trop 44:621-6. 2011
    b>Leprosy is a potentially disabling infectious disease that evolves into emotional issues due to the prejudice that persists about the illness...
  27. pmc From genome-based in silico predictions to ex vivo verification of leprosy diagnosis
    Annemieke Geluk
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Vaccine Immunol 16:352-9. 2009
    The detection of hundreds of thousands of new cases of leprosy every year suggests that transmission of Mycobacterium leprae infection still continues. Unfortunately, tools for identification of asymptomatic disease and/or early-stage M...
  28. ncbi Leprosy type 1 (reversal) reactions and their management
    Stephen L Walker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Lepr Rev 79:372-86. 2008
    The type of leprosy that affects an individual depends on the immune response mounted against the organism. This leads to a spectrum of disease which may be complicated by immunological phenomena called reactions...
  29. pmc Leprosy: too complex a disease for a simple elimination paradigm
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 83:230-5. 2005
    Can leprosy be eliminated? This paper considers the question against the background of the WHO programme to eliminate leprosy. In 1991 the World Health Assembly set a target of eliminating leprosy as a public health problem by 2000...
  30. pmc The innate immune response in leprosy
    Robert L Modlin
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA
    Curr Opin Immunol 22:48-54. 2010
    Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease...
  31. pmc Leprosy and the human genome
    Elizabeth A Misch
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Microbiol Mol Biol Rev 74:589-620. 2010
    Despite the availability of effective treatment for several decades, leprosy remains an important medical problem in many regions of the world...
  32. pmc Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection
    Annemieke Geluk
    Department of Infectious Diseases Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Clin Vaccine Immunol 15:522-33. 2008
    The stable incidence of new leprosy cases suggests that transmission of infection is continuing despite the worldwide implementation of multidrug therapy programs...
  33. doi Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions
    Ron P Schuring
    Royal Tropical Institute KIT Biomedical Research, Department of Dermatology, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 199:1816-9. 2009
    ..a polymorphism of a key innate immunity receptor, Toll-like receptor 1 (TLR1) N248S, and susceptibility to leprosy and its clinical presentation...
  34. pmc Leprosy and the adaptation of human toll-like receptor 1
    Sunny H Wong
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 6:e1000979. 2010
    b>Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world...
  35. pmc Multidrug resistant Mycobacterium leprae from patients with leprosy
    S Maeda
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan
    Antimicrob Agents Chemother 45:3635-9. 2001
    Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14...
  36. pmc Ocular leprosy in institutionalized Nigerian patients
    J A Ebeigbe
    Department of Optometry, University of Benin, P M B 1154, Benin, Edo State 300001, Nigeria
    Ghana Med J 45:50-3. 2011
    This study was aimed at presenting the profile of ocular lesions observed in the in-mates on multidrug treatment, of a leprosy rehabilitation centre in Nigeria.
  37. pmc Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy
    John S Spencer
    Department of Microbiology, Immunology and Pathology, Colorado State University, Campus Delivery 1682, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 18:260-7. 2011
    ..serodiagnostic test based on the Mycobacterium leprae-specific phenolic glycolipid I(PGL-I), for individuals with leprosy is nearly universally positive in leprosy patients with high bacillary loads but cannot be used as a stand-alone ..
  38. pmc Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy
    P Y Bochud
    Institute for Systems Biology, Seattle, WA, USA
    Eur J Clin Microbiol Infect Dis 28:1055-65. 2009
    ..polymorphisms in Toll-like receptors (TLRs) influence the pathogenesis of mycobacterial infections, including leprosy, a disease whose manifestations depend on host immune responses...
  39. pmc Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays
    Annemieke Geluk
    Department of Infectious Diseases, LUMC, P O Box 9600, 2300 RC Leiden, Netherlands
    Clin Vaccine Immunol 17:993-1004. 2010
    Although worldwide leprosy prevalence has been reduced considerably following multidrug therapy, new case detection rates remain relatively stable, suggesting that transmission of infection still continues...
  40. ncbi Leprosy and tuberculosis: an insight-review
    Tahziba Hussain
    HIV AIDS Unit, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Indian Council of Medical Research, Tajganj, Agra, India
    Crit Rev Microbiol 33:15-66. 2007
    ..leprae and M. tuberculosis, their genome, Lepromin and Tuberculin testing, Global scenario, Indian scenario, colonies of M. leprae and M. tuberculosis, drugs for treatment of tuberculosis and leprosy (MDT blister pack), and so on.
  41. ncbi Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy
    Laarni G Villahermosa
    Leonard Wood Memorial Center for Leprosy Research, Cebu, The Philippines
    Am J Trop Med Hyg 70:197-200. 2004
    ..doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy. Patients with MB leprosy received ROM (n = 10) or World Health Organization multi-drug therapy (MDT) (n = 11)...
  42. ncbi The dynamics of stigma in leprosy
    M L Heijnders
    Research Fellow, Trimbos Institute
    Int J Lepr Other Mycobact Dis 72:437-47. 2004
    b>Leprosy in Nepal is a stigmatizing disease. This paper explores the different coping strategies employed by people affected by leprosy to manage stigma. It is based on a qualitative study conducted in the eastern part of Nepal...
  43. doi Tuberculosis and leprosy in perspective
    Anne C Stone
    School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, USA
    Am J Phys Anthropol 140:66-94. 2009
    Two of humankind's most socially and psychologically devastating diseases, tuberculosis and leprosy, have been the subject of intensive paleopathological research due to their antiquity, a presumed association with human settlement and ..
  44. ncbi Noncarious cervical lesions among a non-toothbrushing population with Hansen's disease (leprosy): initial findings
    Babacar Faye
    School of Odontology and Medicine, University of Dakar, Dakar, Senegal
    Quintessence Int 37:613-9. 2006
    The purpose of this preliminary investigation was to examine the presence of noncarious cervical lesions (NCCLs) among a convenience sample of non-toothbrushing subjects with Hansen's disease (leprosy).
  45. doi Usage of signaling in neurodegeneration and regeneration of peripheral nerves by leprosy bacteria
    Anura Rambukkana
    The Rockefeller University, 1230, York Avenue, New York, NY, USA
    Prog Neurobiol 91:102-7. 2010
    ..Recent studies have provided evidence that the bacterium that causes human leprosy, Mycobacterium leprae that has a unique capacity to invade Schwann cells of the adult PNS, utilizes the ..
  46. ncbi Analysis on value of household contact survey in case detection of leprosy at a low endemic situation in China
    Jianping Shen
    Department of Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, PR China, 210042
    Indian J Dermatol Venereol Leprol 75:152-6. 2009
    b>Leprosy is at a low endemic situation in China, the value of house contact survey in case detection of leprosy becoming a dispute.
  47. doi IFN-γ +875 microsatellite polymorphism as a potential protection marker for leprosy patients from Amazonas state, Brazil
    G A V Silva
    Programa de Pós graduação em Imunologia Básica e Aplicada PPGIBA, Universidade Federal do Amazonas UFAM, Brazil
    Cytokine 60:493-7. 2012
    ..b>Leprosy patients are characterized by different immune responses in different clinical forms...
  48. ncbi Treatment of leprosy in India
    V P Gautam
    Netherlands Leprosy Relief India, B 38, Panchsheel Enclave, New Delhi, India
    J Postgrad Med 55:220-4. 2009
    Introduction of multi-drug therapy (MDT) into the National Leprosy Eradication Program (NLEP) of India has brought a decline in both the burden of the disease and the detection of new cases in the country...
  49. ncbi Genetic and immunological evidence implicates interleukin 6 as a susceptibility gene for leprosy type 2 reaction
    Ana Lucia M Sousa
    Tropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Brazil
    J Infect Dis 205:1417-24. 2012
    In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and permanent disabilities...
  50. ncbi A study of household contacts of children with leprosy
    N P Madarasingha
    Dermatology Unit, National Hospital of Sri Lanka
    Ceylon Med J 56:112-4. 2011
    The new case detection rate of leprosy and new cases among children remain high in Sri Lanka indicating ongoing transmission. Identification of the positive contacts and the source of infection would break this chain of transmission...
  51. pmc Advances and hurdles on the way toward a leprosy vaccine
    Malcolm S Duthie
    Infectious Disease Research Institute, Seattle, WA USA
    Hum Vaccin 7:1172-83. 2011
    Prevalence rates for leprosy have declined sharply over the past 20 y, with this decline generally attributed to the WHO multi-drug therapy (MDT) campaign to provide free-of-charge treatment to all diagnosed leprosy patients...
  52. pmc Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy
    A H Zea
    Immunotherapy Program, Stanley S Scott Cancer Center, Louisiana State University Medical Center, New Orleans 70112, USA
    Infect Immun 66:499-504. 1998
    Advanced stages of mycobacterial diseases such as leprosy and tuberculosis are characterized by a loss of T-cell function. The basis of this T-cell dysfunction is not well understood...
  53. pmc Leprosy: steps along the journey of eradication
    Brian H Bennett
    University of Medicine and Dentistry of New Jersey School of Public Health, Piscataway, NJ, USA
    Public Health Rep 123:198-205. 2008
  54. pmc Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy
    Rosane B Oliveira
    Division of Dermatology, Department of Microbiology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Infect Immun 71:1427-33. 2003
    Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity...
  55. ncbi Serology: recent developments, strengths, limitations and prospects: a state of the art overview
    Linda Oskam
    Lepr Rev 74:196-205. 2003
    Specific antibodies can be used as a surrogate marker for bacterial load in leprosy. Tests to detect antibodies can be used for (i) the classification of patients for treatment purposes [most multibacillary (MB) patients are seropositive,..
  56. ncbi Massive gene decay in the leprosy bacillus
    S T Cole
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Nature 409:1007-11. 2001
    b>Leprosy, a chronic human neurological disease, results from infection with the obligate intracellular pathogen Mycobacterium leprae, a close relative of the tubercle bacillus...
  57. ncbi Short report: do intestinal nematodes increase the risk for multibacillary leprosy?
    L M Diniz
    Núcleo de Doenças Infecciosas and Pathology Department, Centro Biomedico, Universidade Federal do Espirito Santo, Vitoria, Brazil
    Am J Trop Med Hyg 65:852-4. 2001
    ..frequency of intestinal helminthic infections in patients with the lepromatous form, a multibacillary form of leprosy (odds ratio, 2.99; 95% confidence interval, 1.82-4.95; P = 0...
  58. ncbi Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using Touch-Down (TD) PCR
    Se Kon Kim
    Institute of Hansen s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, South Korea
    FEMS Immunol Med Microbiol 36:27-32. 2003
    ..Sequences of the folP, rpoA, B, and gyrA, B genes were analyzed for isolates of M. leprae from leprosy patients in Korea. We amplified designated region of several genes in M...
  59. ncbi Learning from leprosy: insight into the human innate immune response
    Dennis Montoya
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
    Adv Immunol 105:1-24. 2010
    Investigation into the innate immune response in leprosy has provided insight into host defense and immunopathology in human infectious disease...
  60. ncbi Interactions between HIV infection and leprosy: a paradox
    Andrew P Ustianowski
    The Hospital for Tropical Diseases, London, UK
    Lancet Infect Dis 6:350-60. 2006
    Early in the HIV epidemic it was feared that the disease would undermine leprosy control, as has occurred with tuberculosis...
  61. pmc Molecular epidemiology of Mycobacterium leprae as determined by structure-neighbor clustering
    Barry G Hall
    Bellingham Research Institute, 218 Chuckanut Point Rd, Bellingham, WA 98229, USA
    J Clin Microbiol 48:1997-2008. 2010
    ..It has proven challenging to investigate the molecular epidemiology of Mycobacterium leprae, the causative agent of leprosy, due to difficulties with culturing of the organism and a lack of genetic heterogeneity between strains...
  62. doi Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions
    Davey P Legendre
    Pharmacy Division, Health ManagementAssociates, Woodstock, Georgia, USA
    Pharmacotherapy 32:27-37. 2012
    Hansen's disease, also known as leprosy, remains an important public health problem throughout the world, including North America...
  63. doi BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control
    Corinne S C Merle
    Department of Epidemiology and Population Health, Tropical Epidemiological Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Expert Rev Vaccines 9:209-22. 2010
    ..Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies...
  64. ncbi Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium leprae co-infection: HIV-1 subtypes and clinical, immunologic, and histopathologic profiles in a Brazilian cohort
    Gisner A S Pereira
    Tropical Pathology and Public Health Institute, Federal University of Goias, Rua Delenda Rezende de Melo, s n Setor Universitario, 74 605 050 Goiânia Goiás, Brazil
    Am J Trop Med Hyg 71:679-84. 2004
    ..8% males, 72.2% with paucibacillary leprosy, and 95.4% with acquired immunodeficiency syndrome)...
  65. ncbi [Leprosy in Brazil]
    Marcelo Grossi Araújo
    Servico de Dermatologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Rev Soc Bras Med Trop 36:373-82. 2003
    b>Leprosy or Hansen's disease is a chronic infectious disease caused by the Mycobacterium leprae. The skin and nervous manifestations of the disease present a singular clinical picture that is easily recognized...
  66. ncbi Commentary: leprosy and poverty
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK
    Int J Epidemiol 33:269-70. 2004
  67. ncbi Evaluation of leprosy patients with 1 to 5 skin lesions with relevance to their grouping into paucibacillary or multibacillary disease
    P Narasimha Rao
    Department of Dermatology, Gandhi Medical College, Secunderabad, India
    Indian J Dermatol Venereol Leprol 72:207-10. 2006
    ..With the decreasing prevalence of leprosy in India and modifications in leprosy program, the relevance of this grouping needs further study.
  68. ncbi Socioeconomic, environmental, and behavioural risk factors for leprosy in North-east Brazil: results of a case-control study
    Ligia R S Kerr-Pontes
    Departamento de Saude Comunitaria, Faculdade de Medicina, Universidade Federal do Ceara, R Prof Costa Mendes, 1608 5o Andar, CEP 60431 140 Fortaleza, CE, Brazil
    Int J Epidemiol 35:994-1000. 2006
    Brazil reports almost 80% of all leprosy cases in the Americas. This study aimed to identify socioeconomic, environmental, and behavioural factors associated with risk of leprosy occurrence in the endemic North-eastern region.
  69. pmc Population-based molecular epidemiology of leprosy in Cebu, Philippines
    Rama Murthy Sakamuri
    Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, USA
    J Clin Microbiol 47:2844-54. 2009
    To address the persisting problem of leprosy in Cebu, Philippines, we compiled a database of more than 200 patients who attend an established referral skin clinic...
  70. ncbi A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population
    Kerrie Tosh
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    J Infect Dis 186:1190-3. 2002
    A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis...
  71. doi Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome
    Cynthia Chester Cardoso
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
    Future Microbiol 6:533-49. 2011
    The past few years have been very productive concerning the identification of genes associated with leprosy. Candidate gene strategies using both case-control and family-based designs, as well as large-scale approaches such as linkage ..
  72. ncbi Polymorphism in the rpoT gene in Mycobacterium leprae isolates obtained from Latin American countries and its possible correlation with the spread of leprosy
    Masanori Matsuoka
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1, Aobacho, Higashimurayama shi, 189 0002 Tokyo, Japan
    FEMS Microbiol Lett 243:311-5. 2005
    ..These obvious different distributions might reflect the spread of leprosy by the different strains of M...
  73. pmc The prevalence of previously undiagnosed leprosy in the general population of northwest bangladesh
    Fake J Moet
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 2:e198. 2008
    The prevalence of previously undiagnosed leprosy (PPUL) in the general population was determined to estimate the background level of leprosy in the population and to compare this with registered prevalence and the known PPUL in different ..
  74. ncbi Mycobacterium leprae and leprosy: a compendium
    S Sasaki
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Microbiol Immunol 45:729-36. 2001
    b>Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which was discovered by G.H.A. Hansen in 1873. M. leprae is an exceptional bacterium because of its long generation time and no growth in artificial media...
  75. pmc Effects of prednisolone treatment on cytokine expression in patients with leprosy type 1 reactions
    Anna K Andersson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E HTM, United Kingdom
    Infect Immun 73:3725-33. 2005
    b>Leprosy type 1 reactions (T1R) are due to increased cell-mediated immunity and result in localized tissue damage...
  76. pmc Molecular determination of Mycobacterium leprae viability by use of real-time PCR
    Alejandra N Martinez
    Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
    J Clin Microbiol 47:2124-30. 2009
    Mycobacterium leprae, the etiological agent of leprosy, is noncultivable on axenic media. Therefore, the viability of M. leprae for clinical or experimental applications is often unknown. To provide new tools for M...
  77. ncbi Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes
    M A Shaw
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY
    Genes Immun 2:196-204. 2001
    Previous analyses indicate major gene control of susceptibility to leprosy per se and the HLA class II region has been implicated in determining susceptibility and control of clinical phenotype...
  78. pmc Use of protein antigens for early serological diagnosis of leprosy
    Malcolm S Duthie
    Infectious Disease Research Institute, 1124 Columbia St, Suite 400, Seattle, WA 98104, USA
    Clin Vaccine Immunol 14:1400-8. 2007
    b>Leprosy is a chronic and debilitating human disease caused by infection with the Mycobacterium leprae bacillus...
  79. pmc Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects
    Karina I Carvalho
    Federal University of Sao Paulo, Sao Paulo, Brazil
    Immunology 124:206-14. 2008
    b>Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease...
  80. ncbi Report on the first meeting of the IDEAL (Initiative for Diagnostic and Epidemiological Assays for Leprosy) consortium held at Armauer Hansen Research Institute, ALERT, Addis Ababa, Ethiopia on 24-27 October 2004
    Abraham Aseffa
    Lepr Rev 76:147-59. 2005
  81. ncbi Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy
    Luiz Ricardo Goulart
    Molecular Genetics Laboratory, Institute of Genetics and Biochemistry, Federal University of Uberlandia, MG, Brazil
    FEMS Immunol Med Microbiol 48:91-8. 2006
    ..infections may be the result of incorrect population stratification. The risk of leprosy occurrence conditioned by VDR polymorphism was investigated by stratifying the population of a highly endemic ..
  82. ncbi Genotypic analysis of Mycobacterium leprae isolates from Japan and other Asian countries reveals a global transmission pattern of leprosy
    Masanori Matsuoka
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 261:150-4. 2006
    ..Type 4, TTC, with three copies of 6 bp, was detected only from Japanese Brazilians. The results indicate that infection occurred in Brazil and the disease developed later in Japan...
  83. pmc Antigen discovery: a postgenomic approach to leprosy diagnosis
    Romulo Araoz
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Infect Immun 74:175-82. 2006
    b>Leprosy is an infectious, neurodegenerative disease of humans caused by Mycobacterium leprae...
  84. ncbi Supporting 'the individual' with leprosy: the need for a 'post-elimination strategy'
    John D H Porter
    Lepr Rev 75:2-6. 2004
  85. ncbi The clinical and immunological features of leprosy
    S L Walker
    Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Br Med Bull 77:103-21. 2006
    b>Leprosy is a granulomatous disease affecting the skin and nerves caused by Mycobacterium leprae. It continues to be a significant public health problem...
  86. ncbi Leprosy masquerading as lupus
    James R Alberti
    J Am Acad Dermatol 52:702-3. 2005
  87. ncbi Leprosy and AIDS: two cases of increasing inflammatory reactions at the start of highly active antiretroviral therapy
    P Pignataro
    Leprosy Laboratory, Department of Tropical Medicine, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenida Brasil 4365, Manguinhos, CEP 21045 900 Rio de Janeiro, Brazil
    Eur J Clin Microbiol Infect Dis 23:408-11. 2004
    Reported here are the cases of two HIV-positive patients with skin lesions suggestive of leprosy, based on clinical and pathological analysis, which worsened during the few weeks following initiation of highly active antiretroviral ..
  88. ncbi Knowledge of and attitudes to leprosy among patients and community members: a comparative study in Uttar Pradesh, India
    Pramila Barkataki
    The Leprosy Mission Hospital, Faizabad, Motinagar Post, Faizabad District, Uttar Pradesh 224 201, India
    Lepr Rev 77:62-8. 2006
    The roles of literacy and gender in enhancing help seeking behaviour in leprosy need further research in order to maximize the effectiveness of health education programmes...
  89. ncbi Prevalence of mental distress in the outpatient clinic of a specialized leprosy hospital. Addis Ababa, Ethiopia, 2002
    Ruth Leekassa
    All Africa Leprosy TB and Rehabilitation Training Center ALERT, Addis Ababa, Ethiopia
    Lepr Rev 75:367-75. 2004
    b>Leprosy is a chronic disease that leads to physical disability as a result of nerve damage. Stigma and associated psychosocial problems are common and may increase the risk of mental disorders...
  90. ncbi [Psychiatric disorders and disability among leprosy patients; a review]
    Vesile Senturk
    Uzm, Ankara U Tip Fak, Ankara
    Turk Psikiyatri Derg 15:236-43. 2004
    As a gross estimate, leprosy currently affects 11-16 million patients worldwide There are currently 3600 registered patients in Turkey. The social stigma connected to leprosy makes this disease completely different from others...
  91. ncbi Fine needle aspiration cytology (FNAC) of nerves in leprosy
    M Vijaikumar
    Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
    Lepr Rev 72:171-8. 2001
    b>Leprosy is primarily a disease of the peripheral nerves and a technique that is simpler than nerve biopsy is required to evaluate nerve involvement, especially in pure neuritic (PN) leprosy...
  92. ncbi Perceived social restriction in leprosy-affected inhabitants of a former leprosy colony in northeast Brazil
    Hannah Lesshafft
    Institute of Microbiology and Hygiene, Charite University Medicine, Campus Benjamin Franklin, Hindenburgdamm 27, 12203 Berlin, Germany
    Lepr Rev 81:69-78. 2010
    In Brazil, isolation of individuals affected with leprosy was compulsory by law from 1920 to 1962, but in reality, confinement of patients to leprosaria continued until the 1980s...
  93. pmc Development and validation of a severity scale for leprosy type 1 reactions
    Stephen L Walker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 2:e351. 2008
    To develop a valid and reliable quantitative measure of leprosy Type 1 reactions.
  94. ncbi Assessment of physical impairments in leprosy patients: a comparison between the world health organization (who) disability grade and the Eye-Hand-Foot score
    Marcos Túlio Raposo
    Departamento de Saúde, Universidade Estadual do Sudoeste da Bahia, Jequie, BA, Brasil
    Rev Inst Med Trop Sao Paulo 53:77-81. 2011
    This cross-sectional study assessed the grade of physical impairments in 61 individuals with leprosy receiving multidrug therapy (MDT) under the Brazilian Unified Health System (SUS), and residing in Campina Grande, Paraíba State, ..
  95. ncbi Differential TNFalpha mRNA regulation detected in the epidermis of leprosy patients
    Rosane M B Teles
    Leprosy Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Av Brasil 4365, Manguinhos, CEP 21 045 900, Rio de Janeiro, Brazil
    Arch Dermatol Res 294:355-62. 2002
    ..adhesion molecule-1) genes was evaluated by RT-PCR in the epidermis isolated from biopsies from 25 reactional leprosy patients...
  96. ncbi A continuation: study and characterisation of Mycobacterium leprae short tandem repeat genotypes and transmission of leprosy in Cebu, Philippines
    Rama Murthy Sakamuri
    Colorado State University, Fort Collins, CO, USA
    Lepr Rev 80:272-9. 2009
    To study the stability and allelic diversity of tandem repeat loci in M. leprae in leprosy patients of Cebu, Philippines, and the suitability of multilocus variable number of tandem repeat (VNTR) analysis (MLVA) typing for detecting ..
  97. doi Recent advances in leprosy and Buruli ulcer (Mycobacterium ulcerans infection)
    Douglas S Walsh
    Department of Immunology and Medicine, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Curr Opin Infect Dis 23:445-55. 2010
    After tuberculosis, leprosy (Mycobacterium leprae) and Buruli ulcer (M. ulcerans infection) are the second and third most common mycobacterial infections in humankind, respectively. Recent advances in both diseases are summarized.
  98. pmc Integration of leprosy elimination into primary health care in orissa, India
    M Ruby Siddiqui
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 4:e8351. 2009
    b>Leprosy was eliminated as a public health problem (<1 case per 10,000) in India by December 2005. With this target in sight the need for a separate vertical programme was diminished...
  99. ncbi Socio-cultural aspects of leprosy among the Masalit and Hawsa tribes in the Sudan
    L A el Hassan
    School of Medicine, Ahfad University for Women, Omdurman, Sudan
    Lepr Rev 73:20-8. 2002
    Social and cultural factors influencing knowledge, attitudes and practices (KAP) towards leprosy in two communities in eastern Sudan were studied to determine their effects on treatment seeking and compliance...
  100. ncbi Drug resistance in leprosy
    Masanori Matsuoka
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Jpn J Infect Dis 63:1-7. 2010
    b>Leprosy is caused by Mycobacterium leprae. Currently, leprosy control is mainly based on WHO-recommended multi-drug treatment; thus, emergence of drug resistance is a major concern. M...
  101. ncbi Serum tumor necrosis factor and interleukin 1 in leprosy and during lepra reactions
    S K Parida
    National Institute of Immunology, New Delhi, India
    Clin Immunol Immunopathol 63:23-7. 1992
    ..However, its role in leprosy is yet unclear...

Research Grants78

  1. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2003
    ..ability to invade the peripheral nervous system and to cause nerve damage, which accounts for the disabilities in leprosy patients. This property makes M...
  2. Assess structure and microbial interactions of clay mineral antibacterial agent
    Lynda Williams; Fiscal Year: 2007
    ..In some West African communities, it has replaced tuberculosis and leprosy as the most prevalent mycobacterial disease...
  3. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..against other intracellular organisms with complex life cycles, such as mycobacterial diseases (Tuberculosis, Leprosy, and Buruli ulcer) in which antibiotic resistance is an urgent global threat and vaccines may provide the best ..
  4. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..against other intracellular organisms with complex life cycles, such as mycobacterial diseases (Tuberculosis, Leprosy, and Buruli ulcer) in which antibiotic resistance is an urgent global threat and vaccines may provide the best ..
  5. Systemic AA Amyloidosis Inhibitors
    ALAN SNOW; Fiscal Year: 2009
    ..with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowl disease, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
  6. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowl disease, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
  7. Firing up new treatments against Mycobacterium ulcerans disease (Buruli ulcer)
    Jacques H Grosset; Fiscal Year: 2010
    ..The disease now has higher prevalence than leprosy and/or tuberculosis in some regions of West African countries (notably, Ghana and Benin)...
  8. Firing up new treatments against Mycobacterium ulcerans disease (Buruli ulcer)
    Jacques Grosset; Fiscal Year: 2009
    ..The disease now has higher prevalence than leprosy and/or tuberculosis in some regions of West African countries (notably, Ghana and Benin)...
  9. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2010
    ..roles in mycobacterial physiology and are important immunomodulatory molecules in the course of tuberculosis and leprosy as well as key ligands promoting the entry of mycobacteria into phagocytic and non-phagocytic cells...
  10. STUDIES OF ANTILEPROSY DRUGS IN ANIMALS AND MAN
    John Peters; Fiscal Year: 1980
    Chemotherapy remains the mainstay for treating the millions of leprosy patients throughout the world...
  11. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 2000
    ..in the impoverished Northeast of Brazil include: leishmaniasis, schistosomiasis, filariasis, Chagas' disease, leprosy, malaria, diarrhea due to enteric infections and helminthiasis...
  12. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 1999
    ..in the impoverished Northeast of Brazil include: leishmaniasis, schistosomiasis, filariasis, Chagas' disease, leprosy, malaria, diarrhea due to enteric infections and helminthiasis...
  13. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 2001
    ..in the impoverished Northeast of Brazil include: leishmaniasis, schistosomiasis, filariasis, Chagas' disease, leprosy, malaria, diarrhea due to enteric infections and helminthiasis...
  14. SERODIAGNOSIS OF SUBCLINICAL LEPROSY (PROPOSAL I)
    Thomas Buchanan; Fiscal Year: 1980
    ..leprae specific protein antigen(s) to be used in an immuno-epidemiological study of leprosy in the countries of Sri Lanka (Proposal II) and Mexico (Proposal I)...
  15. Assess structure and microbial interactions of clay mineral antibacterial agent
    Lynda Williams; Fiscal Year: 2006
    ..In some West African communities, it has replaced tuberculosis and leprosy as the most prevalent mycobacterial disease...
  16. Integration and Excision by Serine Intergrases
    Graham F Hatfull; Fiscal Year: 2010
    ..and include Mycobacterium tuberculosis and Mycobacterium leprae, the causative agents of human tuberculosis and leprosy respectively...
  17. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 1999
    ..ability to invade the peripheral nervous system and to cause nerve damage, which accounts for the disabilities in leprosy patients. This property makes M...
  18. CHARACTERIZATION OF MICROBIAL AGENTS RESPONSIBLE FOR VILIUISK ENCEPHALOMYELITIS
    Vivek Nerurkar; Fiscal Year: 1999
    ..circumstantial evidence that VE is a communicable disease with a pattern of dissemination characteristic of leprosy and other latent and chronic infectious diseases...
  19. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2001
    ..ability to invade the peripheral nervous system and to cause nerve damage, which accounts for the disabilities in leprosy patients. This property makes M...
  20. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2002
    ..ability to invade the peripheral nervous system and to cause nerve damage, which accounts for the disabilities in leprosy patients. This property makes M...
  21. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2000
    ..ability to invade the peripheral nervous system and to cause nerve damage, which accounts for the disabilities in leprosy patients. This property makes M...
  22. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 1993
    ..The main objective of this program is to expand our knowledge of the pathogenesis and treatment of schistosomiasis, leprosy and leishmaniasis...
  23. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 1991
    ..The main objective of this program is to expand our knowledge of the pathogenesis and treatment of schistosomiasis, leprosy and leishmaniasis...
  24. TROPICAL MEDICINE RESEARCH CENTER
    Mediadora Saniel; Fiscal Year: 1991
    ..These include three projects on schistosomiasis and one each on malaria and leprosy. Not only are these major infectious tropical diseases endemic in this region but they are also illnesses which ..
  25. MOLECULAR BIOLOGY OF MYCOBACTERIA & THEIR PHAGES
    Graham Hatfull; Fiscal Year: 1990
    ..b>Leprosy afflicts about 12-15 million people worldwide, mostly but not exclusively, in tropical and subtropical regions ..
  26. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2005
    ..currently used by the Mycobacteria Research Laboratories at Colorado State University to support tuberculosis and leprosy research throughout the world to provide a rapid and economic means to obtain information required to develop new ..
  27. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2002
    ..currently used by the Mycobacteria Research Laboratories at Colorado State University to support tuberculosis and leprosy research throughout the world to provide a rapid and economic means to obtain information required to develop new ..
  28. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2003
    ..currently used by the Mycobacteria Research Laboratories at Colorado State University to support tuberculosis and leprosy research throughout the world to provide a rapid and economic means to obtain information required to develop new ..
  29. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2004
    ..currently used by the Mycobacteria Research Laboratories at Colorado State University to support tuberculosis and leprosy research throughout the world to provide a rapid and economic means to obtain information required to develop new ..
  30. ANTI-INFLAMMATORY ACTIVITY OF DAPSONE
    PAULA BOZEMAN; Fiscal Year: 1990
    ..The antimicrobial properties of dapsone have been utilized in the treatment of leprosy and Pneumocystis carinii pneumonia...
  31. Systemic AA Amyloidosis Inhibitors
    ALAN SNOW; Fiscal Year: 2004
    ..with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowel diseases, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
  32. DEVELOP AND EVALUATE NEW LEPROSY AND TB VACCINES
    Thomas Gillis; Fiscal Year: 2002
    ..leprae (ML) or M. tuberculosis (MT) and evaluate four newly created MT vaccines against leprosy. Specific-objectives are (1) prepare plasmid constructs (DNA vaccines) with genes expressing mycobacterial ..
  33. DEVELOP AND EVALUATE NEW LEPROSY AND TB VACCINES
    Thomas Gillis; Fiscal Year: 2001
    ..leprae (ML) or M. tuberculosis (MT) and evaluate four newly created MT vaccines against leprosy. Specific-objectives are (1) prepare plasmid constructs (DNA vaccines) with genes expressing mycobacterial ..
  34. DEVELOP AND EVALUATE NEW LEPROSY AND TB VACCINES
    Thomas Gillis; Fiscal Year: 2000
    ..leprae (ML) or M. tuberculosis (MT) and evaluate four newly created MT vaccines against leprosy. Specific-objectives are (1) prepare plasmid constructs (DNA vaccines) with genes expressing mycobacterial ..
  35. CELLULAR IMMUNITY AND HUMAN DISEASE
    John Dwyer; Fiscal Year: 1980
    ..being examined in normal humans and in patients with suspected immunoregulatory diseases such as sarcoidosis and leprosy using two techniques...
  36. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1991
    ..Diseases in which direct involvement of siderophores has been established include infantile enteritis, leprosy, and tuberculosis...
  37. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1992
    ..Diseases in which direct involvement of siderophores has been established include infantile enteritis, leprosy, and tuberculosis...
  38. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1993
    ..Diseases in which direct involvement of siderophores has been established include infantile enteritis, leprosy, and tuberculosis...
  39. NIDDK IBD Genetics Consortium Genetic Research Center
    Richard H Duerr; Fiscal Year: 2012
    ..pathway genes;GWAS hits that also implicate IL-23 signaling in ankylosing spondylitis, Behcet's disease, leprosy, and psoriasis;and a strong IL-23/Th17 immune pathway research environment at the University of Pittsburgh ..
  40. INTERNATIONAL VACCINE PROGRAM
    Jean Pape; Fiscal Year: 1992
    ..Since 1980 this unit has conducted studies of infantile diarrhea, typhoid fever, sexually transmitted diseases, leprosy, tuberculosis, and particularly HIV infection and AIDS...
  41. GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANES
    James Kramer; Fiscal Year: 2002
    ..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
  42. NEW CUTANEOUS MODEL OF GRANULOMATOUS INFLAMMATION
    William Epstein; Fiscal Year: 1990
    ..of human cutaneous hypersensitivity granulomas, such as sarcoidosis, metal-induced granulomas and tuberculoid leprosy. These diseases create a disabling and crippling condition in patients, and because of a lack of information ..
  43. GRANULOMA INITIATION FACTORS
    William Epstein; Fiscal Year: 1993
    ..of human cutaneous hypersensitivity granulomas such as sarcoidosis, metal induced granulomas and tuberculoid leprosy. These diseases create disabling, crippling conditions in patients, and because of a lack of more precise ..
  44. 2006 Gordon Research Conference on Basement Membranes
    JEFFREY MINER; Fiscal Year: 2006
    ..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
  45. GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANES
    James Kramer; Fiscal Year: 2004
    ..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
  46. NATIONAL CHIMPANZEE BREEDING AND RESEARCH PROGRAM
    William Satterfield; Fiscal Year: 1999
    ..investigations of positive reinforcement training, behavioral enrichment, reversible contraception, clinical leprosy and obesity will continue...
  47. NATIONAL CHIMPANZEE BREEDING AND RESEARCH PROGRAM
    Michale Keeling; Fiscal Year: 1999
    ..investigations of positive reinforcement training, behavioral enrichment, reversible contraception, clinical leprosy and obesity will continue...
  48. IMMUNOLOGY & VACCINES FOR LEPROSY & LEISHMANIASIS
    Barry Bloom; Fiscal Year: 1993
    b>Leprosy and leishmaniasis have many similarities, in that both diseases form a clinical spectrum that correlates with cell mediated immune responsiveness and represent important problems in developing countries...
  49. IMMUNOLOGY & VACCINES FOR LEPROSY & LEISHMANIASIS
    Barry Bloom; Fiscal Year: 1990
    b>Leprosy and leishmaniasis have many similarities, in that both diseases form a clinical spectrum that correlates with cell mediated immune responsiveness and represent important problems in developing countries...
  50. NEURAL-IMMUNE INTERACTIONS IN OCULAR INFLAMMATION
    RAGA MALATY; Fiscal Year: 1991
    ..The purpose of the investigation is to study the neural-immune interactions in leprosy and to apply this information to other forms of intraocular inflammation and peripheral neuropathies...
  51. Molecular typing of Mycobacterium leprae
    Varalakshmi Vissa; Fiscal Year: 2004
    DESCRIPTION (PROVIDED BY APPLICANT): An objective of the 1991 World Health Assembly was the elimination of leprosy as a public health problem by the year 2000...
  52. Molecular typing of Mycobacterium leprae
    Varalakshmi Vissa; Fiscal Year: 2005
    DESCRIPTION (PROVIDED BY APPLICANT): An objective of the 1991 World Health Assembly was the elimination of leprosy as a public health problem by the year 2000...
  53. The role of aquatic Invertebrates in M. ulcerans Disease
    RICHARD MERRITT; Fiscal Year: 2005
    ..ulcerans infection) is the third most frequent mycobacterial disease in humans, next to tuberculosis and leprosy, often causing serious skin ulcerations, deformities, and disability...
  54. The role of aquatic Invertebrates in M. ulcerans Disease
    RICHARD MERRITT; Fiscal Year: 2006
    ..ulcerans infection) is the third most frequent mycobacterial disease in humans, next to tuberculosis and leprosy, often causing serious skin ulcerations, deformities, and disability...
  55. INDUCTION OF IMMUNITY TO MYCOBACTERIUM LEPRAE
    JOSEPHINE CLARK CURTISS; Fiscal Year: 1990
    Mycobacterium leprae is an obligate intracellular parasite that serves as the etiologic agent of leprosy, a disease that afflicts some 15 million individuals worldwide. M...
  56. CD1-RESTRICTED T CELL RESPONSES IN SKIN
    Robert L Modlin; Fiscal Year: 2011
    ..Through study of the skin lesions of leprosy, we discovered a unique function of LC: the ability to present microbial antigens by a langerin-dependent, CD1a-..
  57. Molecular Epidemiology of Leprosy
    Varalakshmi D Vissa; Fiscal Year: 2010
    670,000 new cases of leprosy were detected during the year 2002...
  58. CELL MEDIATED IMMUNITY
    ZANVIL COHN; Fiscal Year: 1990
    ..Model studies of Leprosy and Leishmaniasis are evaluating the factors responsible for the emigratory, vascular and maturational responses ..
  59. Molecular Epidemiology of Leprosy
    Varalakshmi Vissa; Fiscal Year: 2009
    670,000 new cases of leprosy were detected during the year 2002...
  60. Molecular Epidemiology of Leprosy
    Varalakshmi Vissa; Fiscal Year: 2006
    670,000 new cases of leprosy were detected during the year 2002...
  61. INFECTION MODEL OF LEPROMATOUS LEPROSY
    Frank Collins; Fiscal Year: 1990
    ..systemic infections in susceptible strains of mice (C57BL/6 or BALB/c) which resemble human lepromatous leprosy, providing a convenient experimental model with which to study the immunology of the antileprosy response...
  62. REGIONAL PRIMATE RESEARCH CENTER
    NEAL VANSELOW; Fiscal Year: 1993
    ..isolate protective antigens in filariae, analyze proteins associated with the malaria hypnozoite, evaluate leprosy vaccines, examine the etiology of arthritis in nonhuman primates, evaluate measles vaccination in primates, ..
  63. Molecular Epidemiology of Leprosy
    Varalakshmi Vissa; Fiscal Year: 2005
    670,000 new cases of leprosy were detected during the year 2002...
  64. Molecular Epidemiology of Leprosy
    Varalakshmi Vissa; Fiscal Year: 2007
    670,000 new cases of leprosy were detected during the year 2002...