Genomes and Genes
Summary: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.
Publications325 found, 100 shown here
- The biology of nerve injury in leprosyDavid M Scollard
National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr Baton Rouge, LA 70803, USA
Lepr Rev 79:242-53. 2008The steps in the pathogenesis of nerve injury in leprosy are depicted in Figure 1. Localisation of M. leprae to nerve, Schwann cell infection & responses, as yet unknown mechanisms of injury, axonal atrophy, and finally demyelination...
- The continuing challenges of leprosyD M Scollard
Laboratory Research Branch, National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr, Baton Rouge, LA 70803, USA
Clin Microbiol Rev 19:338-81. 2006b>Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans...
- Comparative genomic and phylogeographic analysis of Mycobacterium lepraeMarc Monot
Institut Pasteur, Paris, France
Nat Genet 41:1282-9. 2009..31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M...
- Leprosy now: epidemiology, progress, challenges, and research gapsLaura C Rodrigues
Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
Lancet Infect Dis 11:464-70. 2011b>Leprosy continues to be a challenge to health worldwide, with about 250,000 new cases being detected every year. Despite widespread implementation of effective multidrug therapy, leprosy has not been eliminated...
- MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosyPhilip T Liu
Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California, USA
Nat Med 18:267-73. 2012b>Leprosy provides a model to investigate mechanisms of immune regulation in humans, given that the disease forms a spectrum of clinical presentations that correlate with host immune responses...
- Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosyFuren Zhang
Shandong Provincial Institute of Dermatology and Venereology, Provincial Academy of Medical Science, Jinan, China
Nat Genet 43:1247-51. 2011We performed a genome-wide association study with 706 individuals with leprosy and 5,581 control individuals and replicated the top 24 SNPs in three independent replication samples, including a total of 3,301 individuals with leprosy and ..
- Susceptibility to leprosy is associated with PARK2 and PACRGMarcelo T Mira
McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
Nature 427:636-40. 2004b>Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year...
- Probable zoonotic leprosy in the southern United StatesRichard W Truman
Bureau of Primary Health Care, Health Resources and Services Administration, Department of Health and Human Services, National Hansen s Disease Program, Louisiana State University, Baton Rouge, USA
N Engl J Med 364:1626-33. 2011In the southern region of the United States, such as in Louisiana and Texas, there are autochthonous cases of leprosy among native-born Americans with no history of foreign exposure...
- IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among BraziliansC C Cardoso
Laboratório de Hanseníase, Instituto Oswaldo Cruz, FIOCRUZ, Av Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040 360, Brazil
Hum Genet 128:481-90. 2010b>Leprosy is a chronic infectious disease caused by Mycobacterium leprae, a low virulence mycobacterium, and the outcome of disease is dependent on the host genetics for either susceptibility per se or severity...
- Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosyPierre Yves Bochud
Institute for Systems Biology, Seattle, WA 98103 8904, USA
J Infect Dis 197:253-61. 2008b>Leprosy is characterized by a spectrum of clinical manifestations that depend on the type of immune response against the pathogen...
- Measuring leprosy stigma--a preliminary review of the leprosy literatureWim H van Brakel
TLM Research Resource Center, 5 Amrita Shergill Marg, New Delhi 110003, India
Int J Lepr Other Mycobact Dis 71:190-7. 2003A literature review was conducted to review work done to date on measuring stigma related to leprosy. References were obtained through a PubMed (Medline) search and through examining relevant bibliographies...
- Gender and leprosy: case studies in Indonesia, Nigeria, Nepal and BrazilCorlien M Varkevisser
Royal Tropical Institute, Amsterdam, The Netherlands
Lepr Rev 80:65-76. 2009There appear to be regional differences in gender ratios of leprosy patients being diagnosed and treated. In Asian countries, more men than women are registered whilst in Africa female patients outnumber males...
- Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesisKatherine A Mattos
Laboratórios de Microbiologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
J Leukoc Biol 87:371-84. 2010..However, the origin and nature of these lipids, as well as their function and contribution to leprosy disease, remain unclear...
- Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosyIara de Messias-Reason
Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Germany
J Infect Dis 199:801-4. 2009Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule...
- Divergence of macrophage phagocytic and antimicrobial programs in leprosyDennis Montoya
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Host Microbe 6:343-53. 2009..The differential regulation of macrophage functional programs was confirmed by analysis of leprosy lesions: the macrophage phagocytosis pathway was prominent in the clinically progressive, multibacillary form of ..
- Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in KoreaEun Young You
Department of Emergency, Boramae Hospital, Seoul National University, 395 Shindaebang 2 dong, Dongjak Gu, Seoul 156 707, South Korea
J Infect 50:6-11. 2005..Identification of the presence and drug resistance of Mycobacterium leprae is key to the diagnosis and treatment of leprosy in non-endemic country like Korea...
- Integrated pathways for neutrophil recruitment and inflammation in leprosyDelphine J Lee
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
J Infect Dis 201:558-69. 2010..disease by means of bioinformatic pathways analysis of the gene expression profiles in the skin lesions of leprosy. In erythema nodosum leprosum (ENL), which occurs in patients with lepromatous leprosy and is characterized by ..
- The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10Ana Carolina F Motta
Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
Braz Dent J 21:158-64. 2010The aim of this study was to determine whether the presence of leprosy reactional episodes could be associated with chronic oral infection...
- Risk factors for developing leprosy--a population-based cohort study in IndonesiaMirjam I Bakker
KIT Koninklijk Instituut voor de Tropen Royal Tropical Institute, KIT Biomedical Research, Amsterdam, The Netherlands
Lepr Rev 77:48-61. 2006We identified risk factors associated with increased yearly incidence rates of leprosy in five island populations. Age, sex, household size and Mycobacterium leprae-specific antibodies as well as contact factors were studied...
- Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibilityA C Pereira
Instituto Lauro de Souza Lima, Bauru, Sao Paulo, Brazil
Genes Immun 10:174-80. 2009b>Leprosy is a complex infectious disease influenced by genetic and environmental factors...
- Prospective study of serological conversion as a risk factor for development of leprosy among household contactsJ T Douglas
Department of Microbiology, University of Hawaii, Honolulu, HI 96822, USA
Clin Diagn Lab Immunol 11:897-900. 2004Although the prevalence of leprosy has declined over the years, there is no evidence that incidence rates are falling...
- TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional studyCynthia C Cardoso
Laboratório de Hanseníase, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
J Infect Dis 204:1256-63. 2011b>Leprosy is an infectious disease caused by Mycobacterium leprae. Tumor necrosis factor (TNF) plays a key role in the host response...
- Association of variants in BAT1-LTA-TNF-BTNL2 genes within 6p21.3 region show graded risk to leprosy in unrelated cohorts of Indian populationShafat Ali
National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
Hum Genet 131:703-16. 2012..Nine SNPs located in BAT1, LTA, TNF genes and BTNL2-DRA interval showed strong association with leprosy susceptibility in two independent sets of North Indian population which was replicated in a geographically ..
- Corticosteroids for treating nerve damage in leprosy. A Cochrane reviewNatasja H J Van Veen
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Lepr Rev 79:361-71. 2008Corticosteroids are commonly used for treating nerve damage in leprosy. We assessed the effectiveness of corticosteroids for treating nerve damage due to leprosy.
- A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairmentStephen L Walker
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Negl Trop Dis 5:e1041. 2011b>Leprosy Type 1 reactions are a major cause of nerve damage and the preventable disability that results. Type 1 reactions are treated with oral corticosteroids and there are few data to support the optimal dose and duration of treatment...
- The impact of leprosy on health-related quality of lifeAnselmo Alves Lustosa
Universidade Federal do Piaui, Teresina, Brazil
Rev Soc Bras Med Trop 44:621-6. 2011b>Leprosy is a potentially disabling infectious disease that evolves into emotional issues due to the prejudice that persists about the illness...
- From genome-based in silico predictions to ex vivo verification of leprosy diagnosisAnnemieke Geluk
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
Clin Vaccine Immunol 16:352-9. 2009The detection of hundreds of thousands of new cases of leprosy every year suggests that transmission of Mycobacterium leprae infection still continues. Unfortunately, tools for identification of asymptomatic disease and/or early-stage M...
- Leprosy type 1 (reversal) reactions and their managementStephen L Walker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
Lepr Rev 79:372-86. 2008The type of leprosy that affects an individual depends on the immune response mounted against the organism. This leads to a spectrum of disease which may be complicated by immunological phenomena called reactions...
- Leprosy: too complex a disease for a simple elimination paradigmDiana N J Lockwood
London School of Hygiene and Tropical Medicine, London, England
Bull World Health Organ 83:230-5. 2005Can leprosy be eliminated? This paper considers the question against the background of the WHO programme to eliminate leprosy. In 1991 the World Health Assembly set a target of eliminating leprosy as a public health problem by 2000...
- The innate immune response in leprosyRobert L Modlin
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA
Curr Opin Immunol 22:48-54. 2010Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease...
- Leprosy and the human genomeElizabeth A Misch
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
Microbiol Mol Biol Rev 74:589-620. 2010Despite the availability of effective treatment for several decades, leprosy remains an important medical problem in many regions of the world...
- Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infectionAnnemieke Geluk
Department of Infectious Diseases Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Clin Vaccine Immunol 15:522-33. 2008The stable incidence of new leprosy cases suggests that transmission of infection is continuing despite the worldwide implementation of multidrug therapy programs...
- Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactionsRon P Schuring
Royal Tropical Institute KIT Biomedical Research, Department of Dermatology, Academic Medical Center, Amsterdam, The Netherlands
J Infect Dis 199:1816-9. 2009..a polymorphism of a key innate immunity receptor, Toll-like receptor 1 (TLR1) N248S, and susceptibility to leprosy and its clinical presentation...
- Leprosy and the adaptation of human toll-like receptor 1Sunny H Wong
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Pathog 6:e1000979. 2010b>Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world...
- Multidrug resistant Mycobacterium leprae from patients with leprosyS Maeda
Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan
Antimicrob Agents Chemother 45:3635-9. 2001Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14...
- Ocular leprosy in institutionalized Nigerian patientsJ A Ebeigbe
Department of Optometry, University of Benin, P M B 1154, Benin, Edo State 300001, Nigeria
Ghana Med J 45:50-3. 2011This study was aimed at presenting the profile of ocular lesions observed in the in-mates on multidrug treatment, of a leprosy rehabilitation centre in Nigeria.
- Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosyJohn S Spencer
Department of Microbiology, Immunology and Pathology, Colorado State University, Campus Delivery 1682, Fort Collins, CO 80523 1682, USA
Clin Vaccine Immunol 18:260-7. 2011..serodiagnostic test based on the Mycobacterium leprae-specific phenolic glycolipid I(PGL-I), for individuals with leprosy is nearly universally positive in leprosy patients with high bacillary loads but cannot be used as a stand-alone ..
- Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosyP Y Bochud
Institute for Systems Biology, Seattle, WA, USA
Eur J Clin Microbiol Infect Dis 28:1055-65. 2009..polymorphisms in Toll-like receptors (TLRs) influence the pathogenesis of mycobacterial infections, including leprosy, a disease whose manifestations depend on host immune responses...
- Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assaysAnnemieke Geluk
Department of Infectious Diseases, LUMC, P O Box 9600, 2300 RC Leiden, Netherlands
Clin Vaccine Immunol 17:993-1004. 2010Although worldwide leprosy prevalence has been reduced considerably following multidrug therapy, new case detection rates remain relatively stable, suggesting that transmission of infection still continues...
- Leprosy and tuberculosis: an insight-reviewTahziba Hussain
HIV AIDS Unit, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Indian Council of Medical Research, Tajganj, Agra, India
Crit Rev Microbiol 33:15-66. 2007..leprae and M. tuberculosis, their genome, Lepromin and Tuberculin testing, Global scenario, Indian scenario, colonies of M. leprae and M. tuberculosis, drugs for treatment of tuberculosis and leprosy (MDT blister pack), and so on.
- Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosyLaarni G Villahermosa
Leonard Wood Memorial Center for Leprosy Research, Cebu, The Philippines
Am J Trop Med Hyg 70:197-200. 2004..doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy. Patients with MB leprosy received ROM (n = 10) or World Health Organization multi-drug therapy (MDT) (n = 11)...
- The dynamics of stigma in leprosyM L Heijnders
Research Fellow, Trimbos Institute
Int J Lepr Other Mycobact Dis 72:437-47. 2004b>Leprosy in Nepal is a stigmatizing disease. This paper explores the different coping strategies employed by people affected by leprosy to manage stigma. It is based on a qualitative study conducted in the eastern part of Nepal...
- Tuberculosis and leprosy in perspectiveAnne C Stone
School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, USA
Am J Phys Anthropol 140:66-94. 2009Two of humankind's most socially and psychologically devastating diseases, tuberculosis and leprosy, have been the subject of intensive paleopathological research due to their antiquity, a presumed association with human settlement and ..
- Noncarious cervical lesions among a non-toothbrushing population with Hansen's disease (leprosy): initial findingsBabacar Faye
School of Odontology and Medicine, University of Dakar, Dakar, Senegal
Quintessence Int 37:613-9. 2006The purpose of this preliminary investigation was to examine the presence of noncarious cervical lesions (NCCLs) among a convenience sample of non-toothbrushing subjects with Hansen's disease (leprosy).
- Usage of signaling in neurodegeneration and regeneration of peripheral nerves by leprosy bacteriaAnura Rambukkana
The Rockefeller University, 1230, York Avenue, New York, NY, USA
Prog Neurobiol 91:102-7. 2010..Recent studies have provided evidence that the bacterium that causes human leprosy, Mycobacterium leprae that has a unique capacity to invade Schwann cells of the adult PNS, utilizes the ..
- Analysis on value of household contact survey in case detection of leprosy at a low endemic situation in ChinaJianping Shen
Department of Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, PR China, 210042
Indian J Dermatol Venereol Leprol 75:152-6. 2009b>Leprosy is at a low endemic situation in China, the value of house contact survey in case detection of leprosy becoming a dispute.
- IFN-γ +875 microsatellite polymorphism as a potential protection marker for leprosy patients from Amazonas state, BrazilG A V Silva
Programa de Pós graduação em Imunologia Básica e Aplicada PPGIBA, Universidade Federal do Amazonas UFAM, Brazil
Cytokine 60:493-7. 2012..b>Leprosy patients are characterized by different immune responses in different clinical forms...
- Treatment of leprosy in IndiaV P Gautam
Netherlands Leprosy Relief India, B 38, Panchsheel Enclave, New Delhi, India
J Postgrad Med 55:220-4. 2009Introduction of multi-drug therapy (MDT) into the National Leprosy Eradication Program (NLEP) of India has brought a decline in both the burden of the disease and the detection of new cases in the country...
- Genetic and immunological evidence implicates interleukin 6 as a susceptibility gene for leprosy type 2 reactionAna Lucia M Sousa
Tropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Brazil
J Infect Dis 205:1417-24. 2012In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and permanent disabilities...
- A study of household contacts of children with leprosyN P Madarasingha
Dermatology Unit, National Hospital of Sri Lanka
Ceylon Med J 56:112-4. 2011The new case detection rate of leprosy and new cases among children remain high in Sri Lanka indicating ongoing transmission. Identification of the positive contacts and the source of infection would break this chain of transmission...
- Advances and hurdles on the way toward a leprosy vaccineMalcolm S Duthie
Infectious Disease Research Institute, Seattle, WA USA
Hum Vaccin 7:1172-83. 2011Prevalence rates for leprosy have declined sharply over the past 20 y, with this decline generally attributed to the WHO multi-drug therapy (MDT) campaign to provide free-of-charge treatment to all diagnosed leprosy patients...
- Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosyA H Zea
Immunotherapy Program, Stanley S Scott Cancer Center, Louisiana State University Medical Center, New Orleans 70112, USA
Infect Immun 66:499-504. 1998Advanced stages of mycobacterial diseases such as leprosy and tuberculosis are characterized by a loss of T-cell function. The basis of this T-cell dysfunction is not well understood...
- Leprosy: steps along the journey of eradicationBrian H Bennett
University of Medicine and Dentistry of New Jersey School of Public Health, Piscataway, NJ, USA
Public Health Rep 123:198-205. 2008
- Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosyRosane B Oliveira
Division of Dermatology, Department of Microbiology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
Infect Immun 71:1427-33. 2003Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity...
- Serology: recent developments, strengths, limitations and prospects: a state of the art overviewLinda Oskam
Lepr Rev 74:196-205. 2003Specific antibodies can be used as a surrogate marker for bacterial load in leprosy. Tests to detect antibodies can be used for (i) the classification of patients for treatment purposes [most multibacillary (MB) patients are seropositive,..
- Massive gene decay in the leprosy bacillusS T Cole
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
Nature 409:1007-11. 2001b>Leprosy, a chronic human neurological disease, results from infection with the obligate intracellular pathogen Mycobacterium leprae, a close relative of the tubercle bacillus...
- Short report: do intestinal nematodes increase the risk for multibacillary leprosy?L M Diniz
Núcleo de Doenças Infecciosas and Pathology Department, Centro Biomedico, Universidade Federal do Espirito Santo, Vitoria, Brazil
Am J Trop Med Hyg 65:852-4. 2001..frequency of intestinal helminthic infections in patients with the lepromatous form, a multibacillary form of leprosy (odds ratio, 2.99; 95% confidence interval, 1.82-4.95; P = 0...
- Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using Touch-Down (TD) PCRSe Kon Kim
Institute of Hansen s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, South Korea
FEMS Immunol Med Microbiol 36:27-32. 2003..Sequences of the folP, rpoA, B, and gyrA, B genes were analyzed for isolates of M. leprae from leprosy patients in Korea. We amplified designated region of several genes in M...
- Learning from leprosy: insight into the human innate immune responseDennis Montoya
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
Adv Immunol 105:1-24. 2010Investigation into the innate immune response in leprosy has provided insight into host defense and immunopathology in human infectious disease...
- Interactions between HIV infection and leprosy: a paradoxAndrew P Ustianowski
The Hospital for Tropical Diseases, London, UK
Lancet Infect Dis 6:350-60. 2006Early in the HIV epidemic it was feared that the disease would undermine leprosy control, as has occurred with tuberculosis...
- Molecular epidemiology of Mycobacterium leprae as determined by structure-neighbor clusteringBarry G Hall
Bellingham Research Institute, 218 Chuckanut Point Rd, Bellingham, WA 98229, USA
J Clin Microbiol 48:1997-2008. 2010..It has proven challenging to investigate the molecular epidemiology of Mycobacterium leprae, the causative agent of leprosy, due to difficulties with culturing of the organism and a lack of genetic heterogeneity between strains...
- Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactionsDavey P Legendre
Pharmacy Division, Health ManagementAssociates, Woodstock, Georgia, USA
Pharmacotherapy 32:27-37. 2012Hansen's disease, also known as leprosy, remains an important public health problem throughout the world, including North America...
- BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy controlCorinne S C Merle
Department of Epidemiology and Population Health, Tropical Epidemiological Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Expert Rev Vaccines 9:209-22. 2010..Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies...
- Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium leprae co-infection: HIV-1 subtypes and clinical, immunologic, and histopathologic profiles in a Brazilian cohortGisner A S Pereira
Tropical Pathology and Public Health Institute, Federal University of Goias, Rua Delenda Rezende de Melo, s n Setor Universitario, 74 605 050 Goiânia Goiás, Brazil
Am J Trop Med Hyg 71:679-84. 2004..8% males, 72.2% with paucibacillary leprosy, and 95.4% with acquired immunodeficiency syndrome)...
- [Leprosy in Brazil]Marcelo Grossi Araújo
Servico de Dermatologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Rev Soc Bras Med Trop 36:373-82. 2003b>Leprosy or Hansen's disease is a chronic infectious disease caused by the Mycobacterium leprae. The skin and nervous manifestations of the disease present a singular clinical picture that is easily recognized...
- Commentary: leprosy and povertyDiana N J Lockwood
London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK
Int J Epidemiol 33:269-70. 2004
- Evaluation of leprosy patients with 1 to 5 skin lesions with relevance to their grouping into paucibacillary or multibacillary diseaseP Narasimha Rao
Department of Dermatology, Gandhi Medical College, Secunderabad, India
Indian J Dermatol Venereol Leprol 72:207-10. 2006..With the decreasing prevalence of leprosy in India and modifications in leprosy program, the relevance of this grouping needs further study.
- Socioeconomic, environmental, and behavioural risk factors for leprosy in North-east Brazil: results of a case-control studyLigia R S Kerr-Pontes
Departamento de Saude Comunitaria, Faculdade de Medicina, Universidade Federal do Ceara, R Prof Costa Mendes, 1608 5o Andar, CEP 60431 140 Fortaleza, CE, Brazil
Int J Epidemiol 35:994-1000. 2006Brazil reports almost 80% of all leprosy cases in the Americas. This study aimed to identify socioeconomic, environmental, and behavioural factors associated with risk of leprosy occurrence in the endemic North-eastern region.
- Population-based molecular epidemiology of leprosy in Cebu, PhilippinesRama Murthy Sakamuri
Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, USA
J Clin Microbiol 47:2844-54. 2009To address the persisting problem of leprosy in Cebu, Philippines, we compiled a database of more than 200 patients who attend an established referral skin clinic...
- A region of chromosome 20 is linked to leprosy susceptibility in a South Indian populationKerrie Tosh
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
J Infect Dis 186:1190-3. 2002A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis...
- Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcomeCynthia Chester Cardoso
Laboratório de Hanseníase, Instituto Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
Future Microbiol 6:533-49. 2011The past few years have been very productive concerning the identification of genes associated with leprosy. Candidate gene strategies using both case-control and family-based designs, as well as large-scale approaches such as linkage ..
- Polymorphism in the rpoT gene in Mycobacterium leprae isolates obtained from Latin American countries and its possible correlation with the spread of leprosyMasanori Matsuoka
Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1, Aobacho, Higashimurayama shi, 189 0002 Tokyo, Japan
FEMS Microbiol Lett 243:311-5. 2005..These obvious different distributions might reflect the spread of leprosy by the different strains of M...
- The prevalence of previously undiagnosed leprosy in the general population of northwest bangladeshFake J Moet
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
PLoS Negl Trop Dis 2:e198. 2008The prevalence of previously undiagnosed leprosy (PPUL) in the general population was determined to estimate the background level of leprosy in the population and to compare this with registered prevalence and the known PPUL in different ..
- Mycobacterium leprae and leprosy: a compendiumS Sasaki
Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
Microbiol Immunol 45:729-36. 2001b>Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which was discovered by G.H.A. Hansen in 1873. M. leprae is an exceptional bacterium because of its long generation time and no growth in artificial media...
- Effects of prednisolone treatment on cytokine expression in patients with leprosy type 1 reactionsAnna K Andersson
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E HTM, United Kingdom
Infect Immun 73:3725-33. 2005b>Leprosy type 1 reactions (T1R) are due to increased cell-mediated immunity and result in localized tissue damage...
- Molecular determination of Mycobacterium leprae viability by use of real-time PCRAlejandra N Martinez
Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
J Clin Microbiol 47:2124-30. 2009Mycobacterium leprae, the etiological agent of leprosy, is noncultivable on axenic media. Therefore, the viability of M. leprae for clinical or experimental applications is often unknown. To provide new tools for M...
- Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genesM A Shaw
Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY
Genes Immun 2:196-204. 2001Previous analyses indicate major gene control of susceptibility to leprosy per se and the HLA class II region has been implicated in determining susceptibility and control of clinical phenotype...
- Use of protein antigens for early serological diagnosis of leprosyMalcolm S Duthie
Infectious Disease Research Institute, 1124 Columbia St, Suite 400, Seattle, WA 98104, USA
Clin Vaccine Immunol 14:1400-8. 2007b>Leprosy is a chronic and debilitating human disease caused by infection with the Mycobacterium leprae bacillus...
- Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjectsKarina I Carvalho
Federal University of Sao Paulo, Sao Paulo, Brazil
Immunology 124:206-14. 2008b>Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease...
- Report on the first meeting of the IDEAL (Initiative for Diagnostic and Epidemiological Assays for Leprosy) consortium held at Armauer Hansen Research Institute, ALERT, Addis Ababa, Ethiopia on 24-27 October 2004Abraham Aseffa
Lepr Rev 76:147-59. 2005
- Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosyLuiz Ricardo Goulart
Molecular Genetics Laboratory, Institute of Genetics and Biochemistry, Federal University of Uberlandia, MG, Brazil
FEMS Immunol Med Microbiol 48:91-8. 2006..infections may be the result of incorrect population stratification. The risk of leprosy occurrence conditioned by VDR polymorphism was investigated by stratifying the population of a highly endemic ..
- Genotypic analysis of Mycobacterium leprae isolates from Japan and other Asian countries reveals a global transmission pattern of leprosyMasanori Matsuoka
Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
FEMS Microbiol Lett 261:150-4. 2006..Type 4, TTC, with three copies of 6 bp, was detected only from Japanese Brazilians. The results indicate that infection occurred in Brazil and the disease developed later in Japan...
- Antigen discovery: a postgenomic approach to leprosy diagnosisRomulo Araoz
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
Infect Immun 74:175-82. 2006b>Leprosy is an infectious, neurodegenerative disease of humans caused by Mycobacterium leprae...
- Supporting 'the individual' with leprosy: the need for a 'post-elimination strategy'John D H Porter
Lepr Rev 75:2-6. 2004
- The clinical and immunological features of leprosyS L Walker
Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
Br Med Bull 77:103-21. 2006b>Leprosy is a granulomatous disease affecting the skin and nerves caused by Mycobacterium leprae. It continues to be a significant public health problem...
- Leprosy masquerading as lupusJames R Alberti
J Am Acad Dermatol 52:702-3. 2005
- Leprosy and AIDS: two cases of increasing inflammatory reactions at the start of highly active antiretroviral therapyP Pignataro
Leprosy Laboratory, Department of Tropical Medicine, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenida Brasil 4365, Manguinhos, CEP 21045 900 Rio de Janeiro, Brazil
Eur J Clin Microbiol Infect Dis 23:408-11. 2004Reported here are the cases of two HIV-positive patients with skin lesions suggestive of leprosy, based on clinical and pathological analysis, which worsened during the few weeks following initiation of highly active antiretroviral ..
- Knowledge of and attitudes to leprosy among patients and community members: a comparative study in Uttar Pradesh, IndiaPramila Barkataki
The Leprosy Mission Hospital, Faizabad, Motinagar Post, Faizabad District, Uttar Pradesh 224 201, India
Lepr Rev 77:62-8. 2006The roles of literacy and gender in enhancing help seeking behaviour in leprosy need further research in order to maximize the effectiveness of health education programmes...
- Prevalence of mental distress in the outpatient clinic of a specialized leprosy hospital. Addis Ababa, Ethiopia, 2002Ruth Leekassa
All Africa Leprosy TB and Rehabilitation Training Center ALERT, Addis Ababa, Ethiopia
Lepr Rev 75:367-75. 2004b>Leprosy is a chronic disease that leads to physical disability as a result of nerve damage. Stigma and associated psychosocial problems are common and may increase the risk of mental disorders...
- [Psychiatric disorders and disability among leprosy patients; a review]Vesile Senturk
Uzm, Ankara U Tip Fak, Ankara
Turk Psikiyatri Derg 15:236-43. 2004As a gross estimate, leprosy currently affects 11-16 million patients worldwide There are currently 3600 registered patients in Turkey. The social stigma connected to leprosy makes this disease completely different from others...
- Fine needle aspiration cytology (FNAC) of nerves in leprosyM Vijaikumar
Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
Lepr Rev 72:171-8. 2001b>Leprosy is primarily a disease of the peripheral nerves and a technique that is simpler than nerve biopsy is required to evaluate nerve involvement, especially in pure neuritic (PN) leprosy...
- Perceived social restriction in leprosy-affected inhabitants of a former leprosy colony in northeast BrazilHannah Lesshafft
Institute of Microbiology and Hygiene, Charite University Medicine, Campus Benjamin Franklin, Hindenburgdamm 27, 12203 Berlin, Germany
Lepr Rev 81:69-78. 2010In Brazil, isolation of individuals affected with leprosy was compulsory by law from 1920 to 1962, but in reality, confinement of patients to leprosaria continued until the 1980s...
- Development and validation of a severity scale for leprosy type 1 reactionsStephen L Walker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Negl Trop Dis 2:e351. 2008To develop a valid and reliable quantitative measure of leprosy Type 1 reactions.
- Assessment of physical impairments in leprosy patients: a comparison between the world health organization (who) disability grade and the Eye-Hand-Foot scoreMarcos Túlio Raposo
Departamento de Saúde, Universidade Estadual do Sudoeste da Bahia, Jequie, BA, Brasil
Rev Inst Med Trop Sao Paulo 53:77-81. 2011This cross-sectional study assessed the grade of physical impairments in 61 individuals with leprosy receiving multidrug therapy (MDT) under the Brazilian Unified Health System (SUS), and residing in Campina Grande, Paraíba State, ..
- Differential TNFalpha mRNA regulation detected in the epidermis of leprosy patientsRosane M B Teles
Leprosy Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Av Brasil 4365, Manguinhos, CEP 21 045 900, Rio de Janeiro, Brazil
Arch Dermatol Res 294:355-62. 2002..adhesion molecule-1) genes was evaluated by RT-PCR in the epidermis isolated from biopsies from 25 reactional leprosy patients...
- A continuation: study and characterisation of Mycobacterium leprae short tandem repeat genotypes and transmission of leprosy in Cebu, PhilippinesRama Murthy Sakamuri
Colorado State University, Fort Collins, CO, USA
Lepr Rev 80:272-9. 2009To study the stability and allelic diversity of tandem repeat loci in M. leprae in leprosy patients of Cebu, Philippines, and the suitability of multilocus variable number of tandem repeat (VNTR) analysis (MLVA) typing for detecting ..
- Recent advances in leprosy and Buruli ulcer (Mycobacterium ulcerans infection)Douglas S Walsh
Department of Immunology and Medicine, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Curr Opin Infect Dis 23:445-55. 2010After tuberculosis, leprosy (Mycobacterium leprae) and Buruli ulcer (M. ulcerans infection) are the second and third most common mycobacterial infections in humankind, respectively. Recent advances in both diseases are summarized.
- Integration of leprosy elimination into primary health care in orissa, IndiaM Ruby Siddiqui
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 4:e8351. 2009b>Leprosy was eliminated as a public health problem (<1 case per 10,000) in India by December 2005. With this target in sight the need for a separate vertical programme was diminished...
- Socio-cultural aspects of leprosy among the Masalit and Hawsa tribes in the SudanL A el Hassan
School of Medicine, Ahfad University for Women, Omdurman, Sudan
Lepr Rev 73:20-8. 2002Social and cultural factors influencing knowledge, attitudes and practices (KAP) towards leprosy in two communities in eastern Sudan were studied to determine their effects on treatment seeking and compliance...
- Drug resistance in leprosyMasanori Matsuoka
Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
Jpn J Infect Dis 63:1-7. 2010b>Leprosy is caused by Mycobacterium leprae. Currently, leprosy control is mainly based on WHO-recommended multi-drug treatment; thus, emergence of drug resistance is a major concern. M...
- Serum tumor necrosis factor and interleukin 1 in leprosy and during lepra reactionsS K Parida
National Institute of Immunology, New Delhi, India
Clin Immunol Immunopathol 63:23-7. 1992..However, its role in leprosy is yet unclear...
- MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGEAnura Rambukkana; Fiscal Year: 2003..ability to invade the peripheral nervous system and to cause nerve damage, which accounts for the disabilities in leprosy patients. This property makes M...
- Assess structure and microbial interactions of clay mineral antibacterial agentLynda Williams; Fiscal Year: 2007..In some West African communities, it has replaced tuberculosis and leprosy as the most prevalent mycobacterial disease...
- Firing up new treatments against Mycobacterium ulcerans disease (Buruli ulcer)Jacques H Grosset; Fiscal Year: 2010..The disease now has higher prevalence than leprosy and/or tuberculosis in some regions of West African countries (notably, Ghana and Benin)...
- Biogenesis of lipoarabinomannan in mycobacteriaMary Jackson; Fiscal Year: 2010..roles in mycobacterial physiology and are important immunomodulatory molecules in the course of tuberculosis and leprosy as well as key ligands promoting the entry of mycobacteria into phagocytic and non-phagocytic cells...
- Integration and Excision by Serine IntergrasesGraham F Hatfull; Fiscal Year: 2010..and include Mycobacterium tuberculosis and Mycobacterium leprae, the causative agents of human tuberculosis and leprosy respectively...
- Molecular Definition of Mycobacterium paratuberculosisJULIA INAMINE; Fiscal Year: 2005..currently used by the Mycobacteria Research Laboratories at Colorado State University to support tuberculosis and leprosy research throughout the world to provide a rapid and economic means to obtain information required to develop new ..
- Systemic AA Amyloidosis InhibitorsALAN SNOW; Fiscal Year: 2004..with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowel diseases, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
- COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORTKenneth Raymond; Fiscal Year: 1993..Diseases in which direct involvement of siderophores has been established include infantile enteritis, leprosy, and tuberculosis...
- GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANESJames Kramer; Fiscal Year: 2002..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
- 2006 Gordon Research Conference on Basement MembranesJEFFREY MINER; Fiscal Year: 2006..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
- GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANESJames Kramer; Fiscal Year: 2004..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
- Molecular typing of Mycobacterium lepraeVaralakshmi Vissa; Fiscal Year: 2005DESCRIPTION (PROVIDED BY APPLICANT): An objective of the 1991 World Health Assembly was the elimination of leprosy as a public health problem by the year 2000...
- The role of aquatic Invertebrates in M. ulcerans DiseaseRICHARD MERRITT; Fiscal Year: 2006..ulcerans infection) is the third most frequent mycobacterial disease in humans, next to tuberculosis and leprosy, often causing serious skin ulcerations, deformities, and disability...
- Molecular Epidemiology of LeprosyVaralakshmi D Vissa; Fiscal Year: 2010670,000 new cases of leprosy were detected during the year 2002...
- Molecular Epidemiology of LeprosyVaralakshmi Vissa; Fiscal Year: 2009670,000 new cases of leprosy were detected during the year 2002...