leprosy

Summary

Summary: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.

Top Publications

  1. ncbi The biology of nerve injury in leprosy
    David M Scollard
    National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr Baton Rouge, LA 70803, USA
    Lepr Rev 79:242-53. 2008
  2. pmc The continuing challenges of leprosy
    D M Scollard
    Laboratory Research Branch, National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr, Baton Rouge, LA 70803, USA
    Clin Microbiol Rev 19:338-81. 2006
  3. pmc MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy
    Philip T Liu
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California, USA
    Nat Med 18:267-73. 2012
  4. ncbi Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection
    Toshihiro Masaki
    MRC Center for Regenerative Medicine, University of Edinburgh, Little France Campus, Edinburgh, EH16 4UU Scotland, UK
    Cell 152:51-67. 2013
  5. ncbi Curing the stigma of leprosy
    Joy Rafferty
    Lepr Rev 76:119-26. 2005
  6. ncbi Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy
    Furen Zhang
    Shandong Provincial Institute of Dermatology and Venereology, Provincial Academy of Medical Science, Jinan, China
    Nat Genet 43:1247-51. 2011
  7. ncbi Leprosy now: epidemiology, progress, challenges, and research gaps
    Laura C Rodrigues
    Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Infect Dis 11:464-70. 2011
  8. ncbi Comparative genomic and phylogeographic analysis of Mycobacterium leprae
    Marc Monot
    Institut Pasteur, Paris, France
    Nat Genet 41:1282-9. 2009
  9. pmc New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy
    Annemieke Geluk
    Department of Infectious Diseases, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands
    J Immunol 188:4782-91. 2012
  10. ncbi Measuring leprosy-related stigma - a pilot study to validate a toolkit of instruments
    Carin Rensen
    Royal Tropical Institute, Department of Development Policy and Practice, Leprosy Unit, Amsterdam, The Netherlands
    Disabil Rehabil 33:711-9. 2011

Detail Information

Publications358 found, 100 shown here

  1. ncbi The biology of nerve injury in leprosy
    David M Scollard
    National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr Baton Rouge, LA 70803, USA
    Lepr Rev 79:242-53. 2008
    The steps in the pathogenesis of nerve injury in leprosy are depicted in Figure 1. Localisation of M. leprae to nerve, Schwann cell infection & responses, as yet unknown mechanisms of injury, axonal atrophy, and finally demyelination...
  2. pmc The continuing challenges of leprosy
    D M Scollard
    Laboratory Research Branch, National Hansen s Disease Programs, LSU SVM, Skip Bertman Dr, Baton Rouge, LA 70803, USA
    Clin Microbiol Rev 19:338-81. 2006
    b>Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans...
  3. pmc MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy
    Philip T Liu
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California, USA
    Nat Med 18:267-73. 2012
    b>Leprosy provides a model to investigate mechanisms of immune regulation in humans, given that the disease forms a spectrum of clinical presentations that correlate with host immune responses...
  4. ncbi Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection
    Toshihiro Masaki
    MRC Center for Regenerative Medicine, University of Edinburgh, Little France Campus, Edinburgh, EH16 4UU Scotland, UK
    Cell 152:51-67. 2013
    ..Here, we show that the leprosy bacterium hijacks this property to reprogram adult Schwann cells, its preferred host niche, to a stage of ..
  5. ncbi Curing the stigma of leprosy
    Joy Rafferty
    Lepr Rev 76:119-26. 2005
    The stigma of leprosy is a real phenomenon in many people's lives that affects their physical, psychological, social and economical well-being. There are many causes for this damaging image of leprosy...
  6. ncbi Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy
    Furen Zhang
    Shandong Provincial Institute of Dermatology and Venereology, Provincial Academy of Medical Science, Jinan, China
    Nat Genet 43:1247-51. 2011
    We performed a genome-wide association study with 706 individuals with leprosy and 5,581 control individuals and replicated the top 24 SNPs in three independent replication samples, including a total of 3,301 individuals with leprosy and ..
  7. ncbi Leprosy now: epidemiology, progress, challenges, and research gaps
    Laura C Rodrigues
    Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Infect Dis 11:464-70. 2011
    b>Leprosy continues to be a challenge to health worldwide, with about 250,000 new cases being detected every year. Despite widespread implementation of effective multidrug therapy, leprosy has not been eliminated...
  8. ncbi Comparative genomic and phylogeographic analysis of Mycobacterium leprae
    Marc Monot
    Institut Pasteur, Paris, France
    Nat Genet 41:1282-9. 2009
    ..31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M...
  9. pmc New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy
    Annemieke Geluk
    Department of Infectious Diseases, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands
    J Immunol 188:4782-91. 2012
    b>Leprosy is not eradicable with currently available diagnostics or interventions, as evidenced by its stable incidence. Early diagnosis of Mycobacterium leprae infection should therefore be emphasized in leprosy research...
  10. ncbi Measuring leprosy-related stigma - a pilot study to validate a toolkit of instruments
    Carin Rensen
    Royal Tropical Institute, Department of Development Policy and Practice, Leprosy Unit, Amsterdam, The Netherlands
    Disabil Rehabil 33:711-9. 2011
    Stigma negatively affects the quality of life of leprosy-affected people. Instruments are needed to assess levels of stigma and to monitor and evaluate stigma reduction interventions...
  11. ncbi Association of variants in BAT1-LTA-TNF-BTNL2 genes within 6p21.3 region show graded risk to leprosy in unrelated cohorts of Indian population
    Shafat Ali
    National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Hum Genet 131:703-16. 2012
    ..Nine SNPs located in BAT1, LTA, TNF genes and BTNL2-DRA interval showed strong association with leprosy susceptibility in two independent sets of North Indian population which was replicated in a geographically ..
  12. pmc Lateral flow assay for simultaneous detection of cellular- and humoral immune responses
    Paul L A M Corstjens
    Department of Molecular Cell Biology Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
    Clin Biochem 44:1241-6. 2011
    ..The development of a cytokine detection assay suitable for detection of multiple biomarkers for improved diagnosis of mycobacterial diseases...
  13. ncbi Disruption of HLA-DR raft, deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a towards T cell hyporesponsiveness in leprosy
    Sudhir Kumar
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Mol Immunol 48:1178-90. 2011
    b>Leprosy, a chronic human disease, results from infection of Mycobacterium leprae. Defective CMI and T cell hyporesponsiveness are the major hallmark of M. leprae pathogenesis...
  14. ncbi Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy
    John S Spencer
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Mem Inst Oswaldo Cruz 107:79-89. 2012
    Although leprosy is curable with drug treatment, the identification of biomarkers of infection, disease progression and treatment efficacy would greatly help to reduce the overall prevalence of the disease...
  15. ncbi The impact of leprosy on health-related quality of life
    Anselmo Alves Lustosa
    Universidade Federal do Piaui, Teresina, Brazil
    Rev Soc Bras Med Trop 44:621-6. 2011
    b>Leprosy is a potentially disabling infectious disease that evolves into emotional issues due to the prejudice that persists about the illness...
  16. ncbi Susceptibility to leprosy is associated with PARK2 and PACRG
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
    Nature 427:636-40. 2004
    b>Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year...
  17. ncbi Viable M. leprae as a research reagent
    R W Truman
    Laboratory Research Branch, Hansen s Disease Programs at LSU SVM, P O Box 25072, Baton Rouge, Louisiana 70894, USA
    Int J Lepr Other Mycobact Dis 69:1-12. 2001
    ..After their harvest from host tissues, leprosy bacilli lost viability quickly...
  18. pmc Leprosy and the adaptation of human toll-like receptor 1
    Sunny H Wong
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 6:e1000979. 2010
    b>Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world...
  19. pmc Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Infect Dis 197:253-61. 2008
    b>Leprosy is characterized by a spectrum of clinical manifestations that depend on the type of immune response against the pathogen...
  20. ncbi TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study
    Cynthia C Cardoso
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
    J Infect Dis 204:1256-63. 2011
    b>Leprosy is an infectious disease caused by Mycobacterium leprae. Tumor necrosis factor (TNF) plays a key role in the host response...
  21. ncbi Insights from animal models on the immunogenetics of leprosy: a review
    Linda B Adams
    Department of Health and Human Services, Health Resources and Services Administration, Bureau of Primary Health Care, National Hansen s Disease Programs, Baton Rouge, LA, USA
    Mem Inst Oswaldo Cruz 107:197-208. 2012
    ..Animal models can contribute to a better understanding of the role of immunogenetics in leprosy through comparative studies helping to confirm the significance of various identified traits and in deciphering ..
  22. ncbi Risk factors for developing leprosy--a population-based cohort study in Indonesia
    Mirjam I Bakker
    KIT Koninklijk Instituut voor de Tropen Royal Tropical Institute, KIT Biomedical Research, Amsterdam, The Netherlands
    Lepr Rev 77:48-61. 2006
    We identified risk factors associated with increased yearly incidence rates of leprosy in five island populations. Age, sex, household size and Mycobacterium leprae-specific antibodies as well as contact factors were studied...
  23. ncbi Postgenomic Mycobacterium leprae antigens for cellular and serological diagnosis of M. leprae exposure, infection and leprosy disease
    Annemieke Geluk
    Department of Infectious Diseases, Leiden University Medical Center, The Netherlands
    Lepr Rev 82:402-21. 2011
    Due to changes in leprosy control programs and the special expertise required for diagnosis, the need for simple rapid diagnostic tests that could be applied in non-expert settings may now be greater than ever before...
  24. ncbi Physical distance, genetic relationship, age, and leprosy classification are independent risk factors for leprosy in contacts of patients with leprosy
    F Johannes Moet
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    J Infect Dis 193:346-53. 2006
    Close contacts of patients with leprosy have a higher risk of developing leprosy. Several risk factors have been identified, including genetic relationship and physical distance...
  25. ncbi Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy
    Alexandre Alcais
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Institut National de la Sante et de la Recherche Medicale, U550, 75015 Paris, France
    Nat Genet 39:517-22. 2007
    Host genetics has an important role in leprosy, and variants in the shared promoter region of PARK2 and PACRG were the first major susceptibility factors identified by positional cloning...
  26. pmc Prospective study of serological conversion as a risk factor for development of leprosy among household contacts
    J T Douglas
    Department of Microbiology, University of Hawaii, Honolulu, HI 96822, USA
    Clin Diagn Lab Immunol 11:897-900. 2004
    Although the prevalence of leprosy has declined over the years, there is no evidence that incidence rates are falling...
  27. ncbi Influence of TNF and IL10 gene polymorphisms in the immunopathogenesis of leprosy in the south of Brazil
    Danilo Santana Alessio Franceschi
    Laboratorio de Imunogenetica, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Av Colombo, 5790, Maringa, PR, CEP 87020 900, Brazil
    Int J Infect Dis 13:493-8. 2009
    To determine whether cytokine polymorphisms are associated with leprosy and/or their subtypes in a Brazilian population.
  28. ncbi Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility
    A C Pereira
    Instituto Lauro de Souza Lima, Bauru, Sao Paulo, Brazil
    Genes Immun 10:174-80. 2009
    b>Leprosy is a complex infectious disease influenced by genetic and environmental factors...
  29. ncbi Genetic variations and interactions in anti-inflammatory cytokine pathway genes in the outcome of leprosy: a study conducted on a MassARRAY platform
    Shweta Aggarwal
    National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, Delhi, India
    J Infect Dis 204:1264-73. 2011
    Mycobacterium leprae is the etiologic pathogen that causes leprosy. The outcome of disease is dependent on the host genetic background.
  30. pmc Use of protein antigens for early serological diagnosis of leprosy
    Malcolm S Duthie
    Infectious Disease Research Institute, 1124 Columbia St, Suite 400, Seattle, WA 98104, USA
    Clin Vaccine Immunol 14:1400-8. 2007
    b>Leprosy is a chronic and debilitating human disease caused by infection with the Mycobacterium leprae bacillus...
  31. pmc Evaluation of qPCR-based assays for leprosy diagnosis directly in clinical specimens
    Alejandra Nóbrega Martínez
    Laboratório de Hanseníase, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS Negl Trop Dis 5:e1354. 2011
    ..To date, no study has evaluated the specificity and sensitivity of different qPCR assays for leprosy diagnosis using a range of clinical samples that could bias molecular results such as difficult-to-diagnose cases...
  32. pmc NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy
    Mirjam Schenk
    Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA
    Nat Med 18:555-63. 2012
    ..In the human mycobacterial infection leprosy, we found that activation of monocytes via nucleotide-binding oligomerization domain-containing protein 2 (NOD2) ..
  33. ncbi The role of Mycobacterium leprae phenolic glycolipid I (PGL-I) in serodiagnosis and in the pathogenesis of leprosy
    John S Spencer
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Lepr Rev 82:344-57. 2011
    ..and also from characterisation of the lipids of skin biopsies from highly bacillary positive lepromatous leprosy patients...
  34. ncbi Measuring leprosy stigma--a preliminary review of the leprosy literature
    Wim H van Brakel
    TLM Research Resource Center, 5 Amrita Shergill Marg, New Delhi 110003, India
    Int J Lepr Other Mycobact Dis 71:190-7. 2003
    A literature review was conducted to review work done to date on measuring stigma related to leprosy. References were obtained through a PubMed (Medline) search and through examining relevant bibliographies...
  35. ncbi Gender and leprosy: case studies in Indonesia, Nigeria, Nepal and Brazil
    Corlien M Varkevisser
    Royal Tropical Institute, Amsterdam, The Netherlands
    Lepr Rev 80:65-76. 2009
    There appear to be regional differences in gender ratios of leprosy patients being diagnosed and treated. In Asian countries, more men than women are registered whilst in Africa female patients outnumber males...
  36. ncbi IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians
    C C Cardoso
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, FIOCRUZ, Av Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040 360, Brazil
    Hum Genet 128:481-90. 2010
    b>Leprosy is a chronic infectious disease caused by Mycobacterium leprae, a low virulence mycobacterium, and the outcome of disease is dependent on the host genetics for either susceptibility per se or severity...
  37. ncbi Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
    Katherine A Mattos
    Laboratórios de Microbiologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    J Leukoc Biol 87:371-84. 2010
    ..However, the origin and nature of these lipids, as well as their function and contribution to leprosy disease, remain unclear...
  38. pmc Leprosy and the human genome
    Elizabeth A Misch
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Microbiol Mol Biol Rev 74:589-620. 2010
    Despite the availability of effective treatment for several decades, leprosy remains an important medical problem in many regions of the world...
  39. ncbi TLR6-driven lipid droplets in Mycobacterium leprae-infected Schwann cells: immunoinflammatory platforms associated with bacterial persistence
    Katherine A Mattos
    Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ 21045 900, Brazil
    J Immunol 187:2548-58. 2011
    The mechanisms responsible for nerve injury in leprosy need further elucidation...
  40. pmc Probable zoonotic leprosy in the southern United States
    Richard W Truman
    Bureau of Primary Health Care, Health Resources and Services Administration, Department of Health and Human Services, National Hansen s Disease Program, Louisiana State University, Baton Rouge, USA
    N Engl J Med 364:1626-33. 2011
    In the southern region of the United States, such as in Louisiana and Texas, there are autochthonous cases of leprosy among native-born Americans with no history of foreign exposure...
  41. pmc The innate immune response in leprosy
    Robert L Modlin
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA
    Curr Opin Immunol 22:48-54. 2010
    Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease...
  42. ncbi Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy
    Iara de Messias-Reason
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Germany
    J Infect Dis 199:801-4. 2009
    Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule...
  43. pmc Divergence of macrophage phagocytic and antimicrobial programs in leprosy
    Dennis Montoya
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Host Microbe 6:343-53. 2009
    ..The differential regulation of macrophage functional programs was confirmed by analysis of leprosy lesions: the macrophage phagocytosis pathway was prominent in the clinically progressive, multibacillary form of ..
  44. ncbi Challenges in immunodiagnostic tests for leprosy
    Annemieke Geluk
    Leiden University Medical Center LUMC, Department of Infectious Diseases, Leiden, The Netherlands
    Expert Opin Med Diagn 7:265-74. 2013
    Despite the effectiveness of multidrug therapy, leprosy still represents a significant global health problem: transmission of Mycobacterium leprae (M...
  45. ncbi The dynamics of stigma in leprosy
    M L Heijnders
    Research Fellow, Trimbos Institute
    Int J Lepr Other Mycobact Dis 72:437-47. 2004
    b>Leprosy in Nepal is a stigmatizing disease. This paper explores the different coping strategies employed by people affected by leprosy to manage stigma. It is based on a qualitative study conducted in the eastern part of Nepal...
  46. ncbi [Immunopathology of leprosy: the complexity of the mechanisms of host immune response to Mycobacterium leprae]
    Isabela Maria Bernardes Goulart
    Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Uberlandia, Uberlandia, MG
    Rev Soc Bras Med Trop 35:365-75. 2002
    b>Leprosy, whose etiologic agent Mycobacterium leprae, is an illness of ample clinical and immunopathological spectrum...
  47. ncbi BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control
    Corinne S C Merle
    Department of Epidemiology and Population Health, Tropical Epidemiological Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Expert Rev Vaccines 9:209-22. 2010
    ..Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies...
  48. ncbi Epidemiologic study of 107 cases of families with leprosy in Duque de Caxias, Rio de Janeiro, Brazil
    Sandra Maria Barbosa Duraes
    Universidade Federal Fluminense, Rio de Janeiro, RJ, Brasil
    An Bras Dermatol 85:339-45. 2010
    ultibacillary patients are the major source of infection in leprosy. Nevertheless, the risk is higher in household contacts between multibacillary patients than paucibacillary patients and in the general population...
  49. ncbi ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli
    Nikos Tapinos
    The Rockefeller University, Bronk Building, Room 501, Box 172, 1230 York Avenue, New York, New York 10021, USA
    Nat Med 12:961-6. 2006
    Demyelination is a common pathologic feature in many neurodegenerative diseases including infection with leprosy-causing Mycobacterium leprae...
  50. pmc Simple and fast lateral flow test for classification of leprosy patients and identification of contacts with high risk of developing leprosy
    S Buhrer-Sekula
    KIT Royal Tropical Institute Biomedical Research, 1105 AZ Amsterdam, The Netherlands
    J Clin Microbiol 41:1991-5. 2003
    The interruption of leprosy transmission is one of the main challenges for leprosy control programs since no consistent evidence exists that transmission has been reduced after the introduction of multidrug therapy...
  51. ncbi Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy
    Laarni G Villahermosa
    Leonard Wood Memorial Center for Leprosy Research, Cebu, The Philippines
    Am J Trop Med Hyg 70:197-200. 2004
    ..doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy. Patients with MB leprosy received ROM (n = 10) or World Health Organization multi-drug therapy (MDT) (n = 11)...
  52. ncbi Oral mucosa as a source of Mycobacterium leprae infection and transmission, and implications of bacterial DNA detection and the immunological status
    T S Martinez
    National Reference Center for Sanitary Dermatology and Leprosy, Hospital das Clinicas, Uberlandia, Brazil
    Clin Microbiol Infect 17:1653-8. 2011
    b>Leprosy is an important health problem in Brazil despite extensive use of multidrug therapy...
  53. pmc Risk and protective factors for leprosy development determined by epidemiological surveillance of household contacts
    Isabela M B Goulart
    Leprosy National Reference Center, Clinics Hospital, School of Medicine, Federal University of Uberlandia, Uberlandia, Brazil
    Clin Vaccine Immunol 15:101-5. 2008
    Household contacts of leprosy patients are the group with the highest risk of developing the disease, and although many risk or prevention factors have been identified, they have not been employed in leprosy-monitoring programs...
  54. ncbi Circulating CD4+ CD25 high FoxP3+ T cells vary in different clinical forms of leprosy
    Enas A S Attia
    Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Int J Dermatol 49:1152-8. 2010
    CD4(+) CD25(high) FoxP3(+) regulatory T cells (T-regs) were reported to increase in chronic infections. We aimed at studying their frequency in leprosy to investigate their role during Mycobacterium leprae infection.
  55. pmc Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy
    P Y Bochud
    Institute for Systems Biology, Seattle, WA, USA
    Eur J Clin Microbiol Infect Dis 28:1055-65. 2009
    ..polymorphisms in Toll-like receptors (TLRs) influence the pathogenesis of mycobacterial infections, including leprosy, a disease whose manifestations depend on host immune responses...
  56. ncbi Toll-like receptor 1 N248S single-nucleotide polymorphism is associated with leprosy risk and regulates immune activation during mycobacterial infection
    Carolinne de Sales Marques
    Laboratório de Hanseníase, Instituto Oswaldo Cruz, Av Brasil 4365, Manguinhos Rio de Janeiro, RJ, Brazil
    J Infect Dis 208:120-9. 2013
    Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported...
  57. ncbi The epidemiological behaviour of leprosy in Brazil
    Maria Lucia Fernandes Penna
    Consultant to the Brazilian National Hansen s Disease Control Program, Secretariat of Health Surveillance, Federal Ministry of Health, Rio de Janeiro, Brazil
    Lepr Rev 80:332-44. 2009
    The elimination strategy reduced known leprosy prevalence but the detection rate remains high in many countries, including Brazil. The high Brazilian detection rate imposes a limit to the reduction of known prevalence in the short term...
  58. ncbi Social participation of people affected by leprosy after discontinuation of multidrug therapy
    Susilene Maria Tonelli Nardi
    Instituto Lauro de Souza Lima, PO Box 62, Bauru SP, 17010 Brazil
    Lepr Rev 82:55-64. 2011
    To evaluate social participation of individuals completing treatment for leprosy and to describe the relationship with physical sequelae and sociodemographic characteristics.
  59. pmc TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
    Stephan R Krutzik
    Division of Dermatology, University of California at Los Angeles, 611 Charles Young Drive East, 536 Boyer Hall, Los Angeles, CA 90095, USA
    Nat Med 11:653-60. 2005
    b>Leprosy enables investigation of mechanisms by which the innate immune system contributes to host defense against infection, because in one form, the disease progresses, and in the other, the infection is limited...
  60. pmc Impact of PGL-I seropositivity on the protective effect of BCG vaccination among leprosy contacts: a cohort study
    Nadia C Duppre
    Leprosy Unit, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil
    PLoS Negl Trop Dis 6:e1711. 2012
    Contacts of leprosy patients are at increased risk of developing leprosy and need to be targeted for early diagnosis...
  61. ncbi Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population
    Audrey V Grant
    Laboratoire de Génétique des Maladies Infectieuses, Institut National de la Sante et de la Recherche Medicale, University Paris Descartes, Sorbonne Paris Cité, Necker Medical School, Paris, France
    J Infect Dis 206:1763-7. 2012
    A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease ..
  62. ncbi Social inequality, urban growth and leprosy in Manaus: a spatial approach
    Elsia Nascimento Belo Imbiriba
    Instituto Leônidas and Maria Deane, Manaus, AM, Brasil
    Rev Saude Publica 43:656-65. 2009
    To analyze the epidemiology of leprosy according to spatial distribution and living conditions of the population.
  63. ncbi Quantitative real-time PCR analysis of Mycobacterium leprae DNA and mRNA in human biopsy material from leprosy and reactional cases
    Nirmala Lini
    Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India
    J Med Microbiol 58:753-9. 2009
    Mycobacterium leprae, the causative agent of leprosy, is uncultivable in defined media. Development of new diagnostic tools which do not depend on growth of bacteria is needed for the early detection of M...
  64. pmc Selection of antigens and development of prototype tests for point-of-care leprosy diagnosis
    Malcolm S Duthie
    Infectious Disease Research Institute, 1124 Columbia St, Suite 400, Seattle, WA 98104, USA
    Clin Vaccine Immunol 15:1590-7. 2008
    b>Leprosy can be a devastating chronic infection that causes nerve function impairment and associated disfigurement...
  65. ncbi Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea
    Eun Young You
    Department of Emergency, Boramae Hospital, Seoul National University, 395 Shindaebang 2 dong, Dongjak Gu, Seoul 156 707, South Korea
    J Infect 50:6-11. 2005
    ..Identification of the presence and drug resistance of Mycobacterium leprae is key to the diagnosis and treatment of leprosy in non-endemic country like Korea...
  66. pmc Integrated pathways for neutrophil recruitment and inflammation in leprosy
    Delphine J Lee
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Infect Dis 201:558-69. 2010
    ..disease by means of bioinformatic pathways analysis of the gene expression profiles in the skin lesions of leprosy. In erythema nodosum leprosum (ENL), which occurs in patients with lepromatous leprosy and is characterized by ..
  67. pmc A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment
    Stephen L Walker
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1041. 2011
    b>Leprosy Type 1 reactions are a major cause of nerve damage and the preventable disability that results. Type 1 reactions are treated with oral corticosteroids and there are few data to support the optimal dose and duration of treatment...
  68. ncbi Corticosteroids for treating nerve damage in leprosy. A Cochrane review
    Natasja H J Van Veen
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Lepr Rev 79:361-71. 2008
    Corticosteroids are commonly used for treating nerve damage in leprosy. We assessed the effectiveness of corticosteroids for treating nerve damage due to leprosy.
  69. ncbi The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10
    Ana Carolina F Motta
    Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 21:158-64. 2010
    The aim of this study was to determine whether the presence of leprosy reactional episodes could be associated with chronic oral infection...
  70. pmc From genome-based in silico predictions to ex vivo verification of leprosy diagnosis
    Annemieke Geluk
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Clin Vaccine Immunol 16:352-9. 2009
    The detection of hundreds of thousands of new cases of leprosy every year suggests that transmission of Mycobacterium leprae infection still continues. Unfortunately, tools for identification of asymptomatic disease and/or early-stage M...
  71. ncbi Leprosy type 1 (reversal) reactions and their management
    Stephen L Walker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Lepr Rev 79:372-86. 2008
    The type of leprosy that affects an individual depends on the immune response mounted against the organism. This leads to a spectrum of disease which may be complicated by immunological phenomena called reactions...
  72. pmc Leprosy: too complex a disease for a simple elimination paradigm
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 83:230-5. 2005
    Can leprosy be eliminated? This paper considers the question against the background of the WHO programme to eliminate leprosy. In 1991 the World Health Assembly set a target of eliminating leprosy as a public health problem by 2000...
  73. pmc Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy
    John S Spencer
    Department of Microbiology, Immunology and Pathology, Colorado State University, Campus Delivery 1682, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 18:260-7. 2011
    ..serodiagnostic test based on the Mycobacterium leprae-specific phenolic glycolipid I(PGL-I), for individuals with leprosy is nearly universally positive in leprosy patients with high bacillary loads but cannot be used as a stand-alone ..
  74. pmc Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection
    Annemieke Geluk
    Department of Infectious Diseases Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Clin Vaccine Immunol 15:522-33. 2008
    The stable incidence of new leprosy cases suggests that transmission of infection is continuing despite the worldwide implementation of multidrug therapy programs...
  75. ncbi Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions
    Ron P Schuring
    Royal Tropical Institute KIT Biomedical Research, Department of Dermatology, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 199:1816-9. 2009
    ..a polymorphism of a key innate immunity receptor, Toll-like receptor 1 (TLR1) N248S, and susceptibility to leprosy and its clinical presentation...
  76. pmc Multidrug resistant Mycobacterium leprae from patients with leprosy
    S Maeda
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan
    Antimicrob Agents Chemother 45:3635-9. 2001
    Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14...
  77. pmc Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays
    Annemieke Geluk
    Department of Infectious Diseases, LUMC, P O Box 9600, 2300 RC Leiden, Netherlands
    Clin Vaccine Immunol 17:993-1004. 2010
    Although worldwide leprosy prevalence has been reduced considerably following multidrug therapy, new case detection rates remain relatively stable, suggesting that transmission of infection still continues...
  78. ncbi Leprosy and tuberculosis: an insight-review
    Tahziba Hussain
    HIV AIDS Unit, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Indian Council of Medical Research, Tajganj, Agra, India
    Crit Rev Microbiol 33:15-66. 2007
    ..leprae and M. tuberculosis, their genome, Lepromin and Tuberculin testing, Global scenario, Indian scenario, colonies of M. leprae and M. tuberculosis, drugs for treatment of tuberculosis and leprosy (MDT blister pack), and so on.
  79. pmc Ocular leprosy in institutionalized Nigerian patients
    J A Ebeigbe
    Department of Optometry, University of Benin, P M B 1154, Benin, Edo State 300001, Nigeria
    Ghana Med J 45:50-3. 2011
    This study was aimed at presenting the profile of ocular lesions observed in the in-mates on multidrug treatment, of a leprosy rehabilitation centre in Nigeria.
  80. pmc Leprosy: steps along the journey of eradication
    Brian H Bennett
    University of Medicine and Dentistry of New Jersey School of Public Health, Piscataway, NJ, USA
    Public Health Rep 123:198-205. 2008
  81. ncbi Analysis on value of household contact survey in case detection of leprosy at a low endemic situation in China
    Jianping Shen
    Department of Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, PR China, 210042
    Indian J Dermatol Venereol Leprol 75:152-6. 2009
    b>Leprosy is at a low endemic situation in China, the value of house contact survey in case detection of leprosy becoming a dispute.
  82. ncbi Short report: do intestinal nematodes increase the risk for multibacillary leprosy?
    L M Diniz
    Núcleo de Doenças Infecciosas and Pathology Department, Centro Biomedico, Universidade Federal do Espirito Santo, Vitoria, Brazil
    Am J Trop Med Hyg 65:852-4. 2001
    ..frequency of intestinal helminthic infections in patients with the lepromatous form, a multibacillary form of leprosy (odds ratio, 2.99; 95% confidence interval, 1.82-4.95; P = 0...
  83. pmc Molecular epidemiology of Mycobacterium leprae as determined by structure-neighbor clustering
    Barry G Hall
    Bellingham Research Institute, 218 Chuckanut Point Rd, Bellingham, WA 98229, USA
    J Clin Microbiol 48:1997-2008. 2010
    ..It has proven challenging to investigate the molecular epidemiology of Mycobacterium leprae, the causative agent of leprosy, due to difficulties with culturing of the organism and a lack of genetic heterogeneity between strains...
  84. pmc Advances and hurdles on the way toward a leprosy vaccine
    Malcolm S Duthie
    Infectious Disease Research Institute, Seattle, WA USA
    Hum Vaccin 7:1172-83. 2011
    Prevalence rates for leprosy have declined sharply over the past 20 y, with this decline generally attributed to the WHO multi-drug therapy (MDT) campaign to provide free-of-charge treatment to all diagnosed leprosy patients...
  85. ncbi A study of household contacts of children with leprosy
    N P Madarasingha
    Dermatology Unit, National Hospital of Sri Lanka
    Ceylon Med J 56:112-4. 2011
    The new case detection rate of leprosy and new cases among children remain high in Sri Lanka indicating ongoing transmission. Identification of the positive contacts and the source of infection would break this chain of transmission...
  86. ncbi Learning from leprosy: insight into the human innate immune response
    Dennis Montoya
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
    Adv Immunol 105:1-24. 2010
    Investigation into the innate immune response in leprosy has provided insight into host defense and immunopathology in human infectious disease...
  87. ncbi Massive gene decay in the leprosy bacillus
    S T Cole
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Nature 409:1007-11. 2001
    b>Leprosy, a chronic human neurological disease, results from infection with the obligate intracellular pathogen Mycobacterium leprae, a close relative of the tubercle bacillus...
  88. ncbi Tuberculosis and leprosy in perspective
    Anne C Stone
    School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, USA
    Am J Phys Anthropol 140:66-94. 2009
    Two of humankind's most socially and psychologically devastating diseases, tuberculosis and leprosy, have been the subject of intensive paleopathological research due to their antiquity, a presumed association with human settlement and ..
  89. ncbi Treatment of leprosy in India
    V P Gautam
    Netherlands Leprosy Relief India, B 38, Panchsheel Enclave, New Delhi, India
    J Postgrad Med 55:220-4. 2009
    Introduction of multi-drug therapy (MDT) into the National Leprosy Eradication Program (NLEP) of India has brought a decline in both the burden of the disease and the detection of new cases in the country...
  90. ncbi Usage of signaling in neurodegeneration and regeneration of peripheral nerves by leprosy bacteria
    Anura Rambukkana
    The Rockefeller University, 1230, York Avenue, New York, NY, USA
    Prog Neurobiol 91:102-7. 2010
    ..Recent studies have provided evidence that the bacterium that causes human leprosy, Mycobacterium leprae that has a unique capacity to invade Schwann cells of the adult PNS, utilizes the ..
  91. ncbi Interactions between HIV infection and leprosy: a paradox
    Andrew P Ustianowski
    The Hospital for Tropical Diseases, London, UK
    Lancet Infect Dis 6:350-60. 2006
    Early in the HIV epidemic it was feared that the disease would undermine leprosy control, as has occurred with tuberculosis...
  92. pmc Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy
    Rosane B Oliveira
    Division of Dermatology, Department of Microbiology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Infect Immun 71:1427-33. 2003
    Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity...
  93. pmc Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy
    A H Zea
    Immunotherapy Program, Stanley S Scott Cancer Center, Louisiana State University Medical Center, New Orleans 70112, USA
    Infect Immun 66:499-504. 1998
    Advanced stages of mycobacterial diseases such as leprosy and tuberculosis are characterized by a loss of T-cell function. The basis of this T-cell dysfunction is not well understood...
  94. ncbi Noncarious cervical lesions among a non-toothbrushing population with Hansen's disease (leprosy): initial findings
    Babacar Faye
    School of Odontology and Medicine, University of Dakar, Dakar, Senegal
    Quintessence Int 37:613-9. 2006
    The purpose of this preliminary investigation was to examine the presence of noncarious cervical lesions (NCCLs) among a convenience sample of non-toothbrushing subjects with Hansen's disease (leprosy).
  95. ncbi Serology: recent developments, strengths, limitations and prospects: a state of the art overview
    Linda Oskam
    Lepr Rev 74:196-205. 2003
    Specific antibodies can be used as a surrogate marker for bacterial load in leprosy. Tests to detect antibodies can be used for (i) the classification of patients for treatment purposes [most multibacillary (MB) patients are seropositive,..
  96. ncbi Genetic and immunological evidence implicates interleukin 6 as a susceptibility gene for leprosy type 2 reaction
    Ana Lucia M Sousa
    Tropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Brazil
    J Infect Dis 205:1417-24. 2012
    In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and permanent disabilities...
  97. ncbi IFN-γ +875 microsatellite polymorphism as a potential protection marker for leprosy patients from Amazonas state, Brazil
    G A V Silva
    Programa de Pós graduação em Imunologia Básica e Aplicada PPGIBA, Universidade Federal do Amazonas UFAM, Brazil
    Cytokine 60:493-7. 2012
    ..b>Leprosy patients are characterized by different immune responses in different clinical forms...
  98. ncbi Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using Touch-Down (TD) PCR
    Se Kon Kim
    Institute of Hansen s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, South Korea
    FEMS Immunol Med Microbiol 36:27-32. 2003
    ..Sequences of the folP, rpoA, B, and gyrA, B genes were analyzed for isolates of M. leprae from leprosy patients in Korea. We amplified designated region of several genes in M...
  99. ncbi Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions
    Davey P Legendre
    Pharmacy Division, Health ManagementAssociates, Woodstock, Georgia, USA
    Pharmacotherapy 32:27-37. 2012
    Hansen's disease, also known as leprosy, remains an important public health problem throughout the world, including North America...
  100. ncbi [Leprosy in Brazil]
    Marcelo Grossi Araújo
    Servico de Dermatologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Rev Soc Bras Med Trop 36:373-82. 2003
    b>Leprosy or Hansen's disease is a chronic infectious disease caused by the Mycobacterium leprae. The skin and nervous manifestations of the disease present a singular clinical picture that is easily recognized...
  101. ncbi Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium leprae co-infection: HIV-1 subtypes and clinical, immunologic, and histopathologic profiles in a Brazilian cohort
    Gisner A S Pereira
    Tropical Pathology and Public Health Institute, Federal University of Goias, Rua Delenda Rezende de Melo, s n Setor Universitario, 74 605 050 Goiânia Goiás, Brazil
    Am J Trop Med Hyg 71:679-84. 2004
    ..8% males, 72.2% with paucibacillary leprosy, and 95.4% with acquired immunodeficiency syndrome)...

Research Grants62

  1. Assess structure and microbial interactions of clay mineral antibacterial agent
    Lynda Williams; Fiscal Year: 2007
    ..In some West African communities, it has replaced tuberculosis and leprosy as the most prevalent mycobacterial disease...
  2. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowl disease, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
  3. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..against other intracellular organisms with complex life cycles, such as mycobacterial diseases (Tuberculosis, Leprosy, and Buruli ulcer) in which antibiotic resistance is an urgent global threat and vaccines may provide the best ..
  4. Coenzyme F420-dependent enzymes in mycobacteria
    Biswarup Mukhopadhyay; Fiscal Year: 2013
    ..This phylum includes Mycobacterium tuberculosis and Mycobacterium leprae, which cause tuberculosis (TB) and leprosy, respectively, and Streptomyces, Nocardia, and Actinomyces that produce numerous antibiotics, anticancer agents, ..
  5. Biogenesis of lipoarabinomannan in mycobacteria
    Mary Jackson; Fiscal Year: 2013
    ..roles in mycobacterial physiology and are important immunomodulatory molecules in the course of tuberculosis and leprosy as well as key ligands promoting the entry of mycobacteria into phagocytic and non-phagocytic cells...
  6. Characterization of the NOD2 NBD domain and role in chronic inflammation
    Jae W Dugan; Fiscal Year: 2013
    ..in NOD2 are linked to Crohn's disease, sarcoidosis, asthma, atopy, peritonitis, graft- versus-host disease, leprosy and Blau syndrome (chronic granulomatous inflammation of the skin, eyes, and joints)...
  7. Integration and Excision by Serine Intergrases
    Graham F Hatfull; Fiscal Year: 2013
    ..and include Mycobacterium tuberculosis and Mycobacterium leprae, the causative agents of human tuberculosis and leprosy respectively...
  8. Molecular Epidemiology of Leprosy
    Varalakshmi D Vissa; Fiscal Year: 2010
    670,000 new cases of leprosy were detected during the year 2002...
  9. Modulating Eicosanoids to Treat Tuberculosis: Personalized, Host-directed Therapy
    David M Tobin; Fiscal Year: 2011
    ..We found that common LTA4H polymorphisms in human populations control susceptibility to TB and leprosy. People with LTA4H genotypes that result in intermediate levels of inflammation are protected from TB...
  10. Tuberculosis Research Institute at MUHAS
    C Fordham von Reyn; Fiscal Year: 2013
    ..MUHAS leadership, the Tanzanian National Tuberculosis and Leprosy Program (NTLP) and former Fogarty trainees have all contributed to planning the new institute...
  11. Mechanisms of Neuronal Competition During Development
    Christopher D Deppmann; Fiscal Year: 2013
    ..has been shown to be involved in endosome stability in the context of pathogen-host interaction (tuberculosis and leprosy)...
  12. NIDDK IBD Genetics Consortium Genetic Research Center
    Richard H Duerr; Fiscal Year: 2013
    ..pathway genes;GWAS hits that also implicate IL-23 signaling in ankylosing spondylitis, Behcet's disease, leprosy, and psoriasis;and a strong IL-23/Th17 immune pathway research environment at the University of Pittsburgh ..
  13. Modulation of Human Immunity by Mycobacterium leprae
    CLAUDIA M A MANCA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Leprosy, caused by the intracellular pathogen Mycobacterium leprae, results in irreversible nerve damage and atrophy of peripheral tissues...
  14. Molecular Analysis of the Host Immune Response in Leprosy
    Robert L Modlin; Fiscal Year: 2013
    ..b>Leprosy provides an extraordinary model to investigate these immunoregulatory processes...
  15. Integration of host lipid metabolism and innate immunity in microbial infection
    Daniel Cruz; Fiscal Year: 2012
    ..Preliminary data demonstrate that infected macrophages in leprosy lesions and in vitro accumulate host- derived oxidized phospholipids that inhibit innate immunity...
  16. Mathematical and Statistical Modeling of Mycobacterial Disease Control
    REBECCA LEE SMITH; Fiscal Year: 2013
    ..the efficacy of mycobacterial disease control programs, focusing on tuberculosis in humans and cattle and on leprosy in humans...
  17. Application of Novel Antigens and Integrated Microfluidics for Leprosy Diagnosis
    Robert L Modlin; Fiscal Year: 2013
    ..leprae and therefore sources of continuing new case detection, enabling rational chemoprophylaxis of leprosy leading not only to decrease in infectious burden but in reductions in nerve damage and disabilities...
  18. Mechanisms of Innate and Acquired Host Defense and Tissue Injury in Skin
    Delphine J Lee; Fiscal Year: 2013
    ..b>Leprosy provides a model for studying the interaction between the systemic and local immune responses in skin, because ..
  19. Divergence of Phagocytic and Antimicrobial Programs in Leprosy
    Robert L Modlin; Fiscal Year: 2013
    ..antimicrobial responses in leprosy. The differential regulation of these pathways optimizes antimicrobial efficiency required for host defense ..
  20. Immunobiology of Leprosy
    Robert L Modlin; Fiscal Year: 2013
    The skin disease leprosy, caused by the Intracellular pathogen Mycobacterium leprae (mLEP), provides an extraordinary model to study cutaneous immune responses for at least three reasons: i) the disease is still a global health and ..
  21. CD1-RESTRICTED T CELL RESPONSES IN SKIN
    Robert L Modlin; Fiscal Year: 2013
    ..Through study of the skin lesions of leprosy, we discovered a unique function of LC: the ability to present microbial antigens by a langerin-dependent, CD1a-..
  22. Family-Based HIV VCT in Patients at Risk for TB
    EDWIN DUNCAN CHARLEBOIS; Fiscal Year: 2010
    ..2,000 TB evaluation patients offered same-day results HIV counseling and testing at the Uganda National TB and , Leprosy Programme outpatient TB clinic at Old Mulago Hospital in Kampala, Uganda...
  23. UGANDA HIV/TB COHRE TRAiNING PROGRAM
    Peter N Mugyenyi; Fiscal Year: 2013
    ..between Joint Clinical Research Centre, Makerere, Gulu and Mbarara Universities of Uganda, Uganda National TB and Leprosy Program, Uganda Ministry of Health, Case Western Reserve University USA and University of Georgia USA...
  24. Leprosy/Armadillo Support and Maintenance
    Patrick Brennan; Fiscal Year: 2009
    ..research reagents to investigators worldwide to assist in the development of skin test antigens used to detect leprosy. The contract also provides researchers with quality controlled Mycobacterium leprae reagents, which include ..
  25. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2005
    ..currently used by the Mycobacteria Research Laboratories at Colorado State University to support tuberculosis and leprosy research throughout the world to provide a rapid and economic means to obtain information required to develop new ..
  26. ANTI-INFLAMMATORY ACTIVITY OF DAPSONE
    PAULA BOZEMAN; Fiscal Year: 1993
    ..The antimicrobial properties of dapsone have been utilized in the treatment of leprosy and Pneumocystis carinii pneumonia...
  27. Systemic AA Amyloidosis Inhibitors
    ALAN SNOW; Fiscal Year: 2004
    ..with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowel diseases, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
  28. INTERNATIONAL VACCINE PROGRAM
    Jean Pape; Fiscal Year: 1993
    ..Since 1980 this unit has conducted studies of infantile diarrhea, typhoid fever, sexually transmitted diseases, leprosy, tuberculosis, and particularly HIV infection and AIDS...
  29. GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANES
    James Kramer; Fiscal Year: 2002
    ..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
  30. GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANES
    James Kramer; Fiscal Year: 2004
    ..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
  31. NATIONAL CHIMPANZEE BREEDING AND RESEARCH PROGRAM
    Michale Keeling; Fiscal Year: 1999
    ..investigations of positive reinforcement training, behavioral enrichment, reversible contraception, clinical leprosy and obesity will continue...
  32. IMMUNOLOGY & VACCINES FOR LEPROSY & LEISHMANIASIS
    Barry Bloom; Fiscal Year: 1993
    b>Leprosy and leishmaniasis have many similarities, in that both diseases form a clinical spectrum that correlates with cell mediated immune responsiveness and represent important problems in developing countries...
  33. INDUCTION OF IMMUNITY TO MYCOBACTERIUM LEPRAE
    JOSEPHINE CLARK CURTISS; Fiscal Year: 1990
    Mycobacterium leprae is an obligate intracellular parasite that serves as the etiologic agent of leprosy, a disease that afflicts some 15 million individuals worldwide. M...
  34. EXPERIMENTAL LEPROSY/VACCINE STUDIES IN MANGABEYS
    Bobby Gormus; Fiscal Year: 1991
    ..the course of disease and treatment and 3) to study the nature of the immune defects in mangabey with LL leprosy. There are 12 to 15 million leprosy patients worldwide, many of them in underdeveloped areas where chemotherapy ..
  35. HUMAN HYBRIDOMAS IN THE ANALYSIS OF AUTOIMMUNE DISEASE
    BERNARD STOLLAR; Fiscal Year: 1990
    ..K. McAdam's laboratory will isolate monoclonal antibodies from patients with leprosy with high levels of circulating immunoglobulin and antinuclear antibody. D...
  36. INFECTION MODEL OF LEPROMATOUS LEPROSY
    Frank Collins; Fiscal Year: 1991
    ..systemic infections in susceptible strains of mice (C57BL/6 or BALB/c) which resemble human lepromatous leprosy, providing a convenient experimental model with which to study the immunology of the antileprosy response...
  37. 2006 Gordon Research Conference on Basement Membranes
    JEFFREY MINER; Fiscal Year: 2006
    ..to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells...
  38. Polymorphisms of the innate immune system in leprosy
    JAMES VARY; Fiscal Year: 2009
    Mycobacterium leprae, the causative agent of leprosy, has caused human disease since ancient times, yet remains an important endemic disease in some countries. Infection with M...
  39. The role of aquatic Invertebrates in M. ulcerans Disease
    RICHARD MERRITT; Fiscal Year: 2006
    ..ulcerans infection) is the third most frequent mycobacterial disease in humans, next to tuberculosis and leprosy, often causing serious skin ulcerations, deformities, and disability...
  40. NEURAL-IMMUNE INTERACTIONS IN OCULAR INFLAMMATION
    RAGA MALATY; Fiscal Year: 1991
    ..The purpose of the investigation is to study the neural-immune interactions in leprosy and to apply this information to other forms of intraocular inflammation and peripheral neuropathies...
  41. IMMUNOLOGY AND IMMUNOTHERAPY OF LEPROSY
    James Krahenbuhl; Fiscal Year: 1990
    ..the in vitro metabolism, efferent and afferent function of mouse and human mononuclear phagocytes in experimental leprosy. Our studies will explore further the already demonstrated defect in the response to lymphokines of lepromatous ..
  42. PATHOBIOLOGY OF HUMAN LEPROSY
    Gilla Kaplan; Fiscal Year: 2002
    ..investigation aimed at understanding the regulation of cell-mediated immunity (CMI) and how it is subverted in leprosy. The focus of the proposal is on the immunologic mechanisms underlying the long term sequelae and complications ..
  43. Genetics of TB: Cytokine Response and Iron
    Leslie Louie; Fiscal Year: 2002
    ..g., leprosy) implicates a role for cytokine profiles in determining the outcome of human infection with Mycobacterium ..
  44. Molecular typing of Mycobacterium leprae
    Varalakshmi Vissa; Fiscal Year: 2005
    DESCRIPTION (PROVIDED BY APPLICANT): An objective of the 1991 World Health Assembly was the elimination of leprosy as a public health problem by the year 2000...
  45. SEROLOGIC DETERMINATION OF LEPROSY IN CHIMPANZEES
    Bobby Gormus; Fiscal Year: 1992
    ..The antibody profiles will detect chimpanzees that have been exposed to leprosy, a disease only recently shown to exist among the DBP chimps, and will identify individuals that are likely to ..
  46. IMMUNOLOGIC DEFECTS IN LEPROMATOUS LEPROSY
    Nahid Mohagheghpour; Fiscal Year: 1991
    ..of cell- mediated immunological unresponsiveness to Mycobacterium leprae seen in patients with lepromatous leprosy (LL). We have demonstrated that the T cell defectin LL patients is reversible invitro...
  47. Leukocyte Immunoglobulin-like Receptors in Cutaneous Host Defense
    Delphine J Lee; Fiscal Year: 2010
    ..This program will promote the command of cellular immunology, as applied to the dermatologic infectious disease, leprosy. Dr...
  48. GORDON RESEARCH CONFERENCE ON BASEMENT MEMBRANCES
    Louis Reichardt; Fiscal Year: 2000
    ..to the pathogenesis of diabetic microvascular disease, and serve as entry sites for infectious agents, such as leprosy, or metastatic cancer cells...
  49. CELLULAR METABOLISM OF AMYLOID PROTEINS IN AGING
    Barbara Schreiber; Fiscal Year: 1999
    Amyloid A (AA) amyloidosis, a complication of inflammatory diseases such as tuberculosis, leprosy and rheumatoid arthritis, occurs more frequently with increasing length of unchecked disease...
  50. Extramural Research Facilities Construction Bioenvironme
    LANCE PERRYMAN; Fiscal Year: 2005
    ..and office space that will support researchers investigating bacterial organisms responsible for tuberculosis and leprosy. These workers currently have no support space available at the Foothills campus, and providing this space will ..
  51. NRAMPL AND PHAGOCYTE FUNCTION
    Philippe Gros; Fiscal Year: 2000
    ..intracellular infections, and polymorphic variants at human NRAMP1 are associated with susceptibility to TB and leprosy in endemic areas of disease...
  52. Leprosy in Premodern Medicine
    Luke Demaitre; Fiscal Year: 2004
    Completion of a 115,000-word illustrated monograph titled, "'A Cancer of the Whole Body': Leprosy in Pre-Modern Medicine," for publication by Johns Hopkins University Press...
  53. METABOLIC MAINTENANCE & GROWTH OF MYCOBACTERIUM LEPRAE
    Scott Franzblau; Fiscal Year: 1992
    ..viable organisms, to explore optimal biophysical and nutritional parameters for the metabolic maintenance of the leprosy bacillus using the following combination of sensitive metabolic assays: a) quantitation of intracellular ..
  54. PATHOBIOLOGY OF HUMAN LEPROSY
    Gilla Kaplan; Fiscal Year: 1991
    ..is a multidisciplinary program designed to study mechanisms of cell mediated immunity and how it is subverted in leprosy. In particular, we will define the cellular mechanisms necessary to mount a cell mediated response to M...
  55. Many Hosts of Mycobacteria Meeting
    Michelle Larsen; Fiscal Year: 2009
    ..provided by applicant): The 3rd annual Many Hosts of Mycobacteria meeting will be held at a historic former leprosy sanatorium in Carville, Louisiana in November 2009...
  56. MYCOBACTERIUM LEPRAE TAXONOMY AND GENETICS
    JOSEPHINE CLARK CURTISS; Fiscal Year: 1993
    Mycobacterium leprae is an obligate intracellular parasite that serves as the etiologic agent of leprosy, a disease that afflicts some 15 million individuals worldwide. M...
  57. NINTH ANNUAL TROPICAL DISEASES SYMPOSIUM
    George Hill; Fiscal Year: 1992
    ..in tropical diseases covering areas such as African trypanosomiasis, schistosomiasis, malaria, leishmaniasis, leprosy and Chagas' disease. Ample time will be available for discussions...
  58. IMMUNOREGULATORY ROLE OF HUMAN CLASS II MHC MOLECULES
    DAVID ECKELS; Fiscal Year: 1991
    ..g., deficient responses to parasitic organisms in schistosomiasis and leprosy) and autoimmunity...
  59. Typhoon Trio Imager
    Carol Wilusz; Fiscal Year: 2007
    ..Most significantly, it will facilitate many programs investigating infectious diseases including tuberculosis, leprosy, various viruses (LaCrosse, HIV, Dengue, West Nile Virus), and prion disease by increasing both the speed and ..
  60. BIOLOGY OF MYCOBACTERIUM LEPRAE MONOCYTE INTERACTION
    MARCUS HORWITZ; Fiscal Year: 1990
    b>Leprosy is one of the major diseases of the world. It afflicts approximately 12-15 million people worldwide, and because of its chronicity, it has tremendous social and economic consequences in addition to health consequences. In the U.S...
  61. COMPARATIVE CULTURAL STUDY OF PSYCHIATRIC ILLNESS
    Mitchell Weiss; Fiscal Year: 1992
    ..In a cultural study of leprosy and mental health, the research has produced a new instrument that integrates epidemiological and anthropological ..