Genomes and Genes
Summary: Infections with bacteria of the genus MYCOBACTERIUM.
Publications228 found, 100 shown here
- Mycobacterium lentiflavum infection in immunocompetent patientChiara Molteni
Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
Emerg Infect Dis 11:119-22. 2005..We describe a case of chronic pulmonary infection in an immunocompetent patient. Our observation confirms clinical, diagnostic, and treatment difficulties in the management of M. lentiflavum infection...
- Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletiiAdrian M Zelazny
Microbiology Service, Department of Laboratory Medicine, NIAD, National Institutes of Health, Bethesda, MD 20892, USA
J Clin Microbiol 47:1985-95. 2009..abscessus and closely related species. Molecular typing complements sequence-based identification and provides information on prevalent clones with possible relevant clinical aspects...
- An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseasesDavid E Griffith
Am J Respir Crit Care Med 175:367-416. 2007
- Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiologyP Maureen Cassidy
Department of Human Services, Oregon Public Health Division, Portland, USA
Clin Infect Dis 49:e124-9. 2009..We sought to estimate NTM disease prevalence in Oregon, and describe disease by site, species, and patient demographic characteristics...
- Molecular characterization of Mycobacterium massiliense and Mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic proceduresCristina Viana-Niero
Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Departamento de Microbiologia, Imunologia e Parasitologia, Rua Botucatu, 862, São Paulo 04023 062, Brazil
J Clin Microbiol 46:850-5. 2008..abscessus...
- PCR restriction fragment length polymorphism analysis (PRA)-algorithm targeting 644 bp Heat Shock Protein 65 (hsp65) gene for differentiation of Mycobacterium sppHong Kim
Department of Microbiology and Liver Research Institute, College of Medicine, Seoul National University, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
J Microbiol Methods 62:199-209. 2005..Our results suggest that this novel PRA offers a simple, rapid, and accurate method for the identification of mycobacteria culture isolates at the species level...
- Innate response of human endothelial cells infected with mycobacteriaBlanca Estela García-Pérez
Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Prolongacion de Carpio y Plan de Ayala S N, Z P 11340, Mexico, D F, Mexico
Immunobiology 216:925-35. 2011..As a whole, our results describe some aspects of the innate response of HUVEC infected by mycobacteria with different virulence and suggest that a strong cytoskeleton mobilization triggers a high NO production in these cells...
- Multicenter cross-sectional study of nontuberculous mycobacterial infections among cystic fibrosis patients, IsraelIsaac Levy
Sheba Medical Center, Tel Hashomer, Israel
Emerg Infect Dis 14:378-84. 2008..17-1.85, respectively). The incidence of NTM pulmonary infections is increasing among cystic fibrosis patients, reflecting the increase in longevity of such patients as well as environmental exposure to various species of mycobacteria...
- Amoebal coculture of "Mycobacterium massiliense" sp. nov. from the sputum of a patient with hemoptoic pneumoniaToidi Adekambi
Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, Université de la Méditteranée, Marseille, France
J Clin Microbiol 42:5493-501. 2004..The type strain has been deposited in the Collection Institut Pasteur as CIP 108297(T) and in Culture Collection of the University of Goteborg, Goteborg, Sweden, as CCUG 48898(T)...
- Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003Theodore K Marras
Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Canada
Thorax 62:661-6. 2007..A study was undertaken of the "isolation prevalence" of pulmonary NTM in Ontario, Canada between 1997 and 2003 and the frequency of pulmonary NTM "disease"...
- Relationship between mycobacteria and amoebae: ecological and epidemiological concernsV Thomas
STERIS Laboratory, CEA DSV IMETI SEPIA, 18 route du Panorama, 92260 Fontenay aux Roses, France
Lett Appl Microbiol 45:349-57. 2007..This review will consider the progress made in understanding the relationships between mycobacteria and amoebae, and their consequences in terms of ecology and epidemiology...
- Insights into early mycobacterial pathogenesis from the zebrafishRobin Lesley
Department of Microbiology, Box 357242, 1959 NE Pacific Street, University of Washington, Seattle, WA 98195, United States
Curr Opin Microbiol 11:277-83. 2008..As these studies uncover new facets of the bacteria-host interactions in tuberculosis they raise even more questions for future investigation...
- Recovery rate of NTM from AFB smear-positive sputum specimens at a medical centre in South KoreaK Jeon
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Int J Tuberc Lung Dis 9:1046-51. 2005..To investigate the recovery rate of non-tuberculous mycobacteria (NTM) from acid-fast bacilli (AFB) smear-positive sputum specimens at a tertiary care medical centre in South Korea with a high pulmonary tuberculosis (PTB) burden...
- Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout miceH Yamada
Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo
Lab Invest 80:759-67. 2000..Our data clearly indicate that IL-1 is important for the generation of early-phase protective immunity against mycobacterial infection...
- Infections due to rapidly growing mycobacteriaMary A De Groote
University of Colorado, Boulder, Colorado, USA
Clin Infect Dis 42:1756-63. 2006..Here, we focus on the members of the rapidly growing mycobacteria because of their emerging importance in both sporadic infections and outbreak settings...
- Burden of unidentifiable mycobacteria in a reference laboratoryE Tortoli
Regional Mycobacteria Reference Center, Microbiology and Virology Laboratory, Careggi Hospital, University of Florence, Florence, Italy
J Clin Microbiol 39:4058-65. 2001..Our report also shows the usefulness of the integration of novel technology to routine diagnosis, especially in cases involving slow-growing microorganisms such as mycobacteria...
- Inaccuracy of single-target sequencing for discriminating species of the Mycobacterium abscessus groupEdouard Macheras
Hopital Ambroise Pare, Boulogne Billancourt, France
J Clin Microbiol 47:2596-600. 2009..Sequence analysis of five housekeeping genes also showed composite patterns in 8 of these 15 isolates...
- Mycobacterium abscessus Glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage TNF-alpha by preventing interaction with TLR2Elizabeth R Rhoades
Cornell Nanoscale Science and Technology Facility, Cornell University, Ithaca, NY 14853, USA
J Immunol 183:1997-2007. 2009..abscessus cell wall masks underlying cell wall lipids involved in stimulating the innate immune response, thereby facilitating colonization. Conversely spontaneous "unmasking" of cell wall lipids may promote airway inflammation...
- Prevalence and associated risk factors of mycobacterial infections in slaughter pigs from Mubende district in UgandaAdrian Muwonge
Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P O Box 8146 Dep, 0033, Oslo, Norway
Trop Anim Health Prod 42:905-13. 2010..This then warrants further molecular investigation to identify the specific Mycobacterium species and their public health importance in this area...
- Outbreak of Mycobacterium abscessus wound infections among "lipotourists" from the United States who underwent abdominoplasty in the Dominican RepublicE Yoko Furuya
Department of Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, New York, USA
Clin Infect Dis 46:1181-8. 2008..Some US residents travel abroad to undergo cosmetic surgery for fat removal, a practice referred to as "lipotourism." Mycobacterium abscessus can cause postsurgical wound infection...
- Adult-onset immunodeficiency in Thailand and TaiwanSarah K Browne
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
N Engl J Med 367:725-34. 2012..Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence are unknown...
- Diagnosis and treatment of lung infection with nontuberculous mycobacteriaSandra M Arend
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
Curr Opin Pulm Med 15:201-8. 2009..This review summarizes recent literature regarding epidemiological, clinical, diagnostic and therapeutic aspects of NTM lung infections...
- Clinical relevance of non-tuberculous mycobacteria isolated in the Nijmegen-Arnhem region, The NetherlandsJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Thorax 64:502-6. 2009..The frequency of clinical isolation of non-tuberculous mycobacteria (NTM) in the Netherlands is increasing, but its clinical relevance is often uncertain...
- Isolation and identification of nontuberculous mycobacteria from water and soil in central IndiaR Narang
Department of Microbiology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Distt Wardha MS, India
Indian J Med Microbiol 27:247-50. 2009..Mycobacterium avium was the only species isolated from both clinical and environmental samples of the same patient; but the isolates did not match using PCR for IS 1311 and IS 1245 spacer sequences...
- Survival of environmental mycobacteria in Acanthamoeba polyphagaToidi Adekambi
Unite des Rickettsies, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Appl Environ Microbiol 72:5974-81. 2006..Further studies are required to examine the effects of various germicidal agents on the survival of WBM in an aquatic environment...
- Necessity of quality-controlled 16S rRNA gene sequence databases: identifying nontuberculous Mycobacterium speciesC Y Turenne
National Reference Centre for Mycobacteriology, National Microbiology Laboratory, Population and Public Health Branch, Canada
J Clin Microbiol 39:3637-48. 2001....
- Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutationS Dupuis
Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM UMR550, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
Science 293:300-3. 2001..It impairs the nuclear accumulation of GAF but not of ISGF3 in heterozygous cells stimulated by IFNs. Thus, the antimycobacterial, but not the antiviral, effects of human IFNs are principally mediated by GAF...
- Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung diseaseEdward D Chan
Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 43:387-93. 2010..However, much remains to be discovered on why seemingly healthy individuals, particularly slender postmenopausal women with thoracic cage anomalies, appear to be at increased risk...
- Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health diseaseKevin L Winthrop
Oregon Health and Science University, Portland, OR 97239, USA
Am J Respir Crit Care Med 182:977-82. 2010..Respiratory specimens with nontuberculous mycobacteria (NTM) are increasingly common; however, pulmonary disease prevalence is unknown...
- Species identification of neglected nontuberculous mycobacteria in a developing countryHasan Shojaei
Isfahan University of Medical Sciences, Isfahan, Iran
Jpn J Infect Dis 64:265-71. 2011..With regard to the complexity of identification, it is recommended that laboratory diagnosis of NTM diseases be centralized by strengthening or setting up quality national and regional infrastructure...
- Efficient differentiation of Mycobacterium abscessus complex isolates to the species level by a novel PCR-based variable-number tandem-repeat assayGo Eun Choi
Department of Laboratory Medicine, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam do 626 770, South Korea
J Clin Microbiol 49:1107-9. 2011..The assay accuracy was confirmed by a multiple-target sequence analysis. The duplex PCR assay is a one-step, reliable, and accurate assay for discriminating M. abscessus species...
- THP-1 cell apoptosis in response to Mycobacterial infectionCarrie J Riendeau
Department of Pathology and Laboratory Medicine Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Infect Immun 71:254-9. 2003..Interference with TNF death signaling may be a virulence mechanism that allows M. tuberculosis to circumvent innate defenses leading to apoptosis of infected host cells...
- Rapid Identification of Mycobacterium tuberculosis and nontuberculous mycobacteria by multiplex, real-time PCRE T Richardson
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
J Clin Microbiol 47:1497-502. 2009..We conclude that this multiplex, real-time PCR assay is a useful diagnostic tool for the rapid and accurate identification of MTC and clinically relevant nontuberculous mycobacteria...
- Direct identification of mycobacteria from MB/BacT alert 3D bottles: comparative evaluation of two commercial probe assaysC Scarparo
Regional Mycobacteria Reference Centre, Laboratory of Clinical Microbiology and Virology, San Bortolo Hospital, Vicenza, Italy
J Clin Microbiol 39:3222-7. 2001....
- Mycobacterial and other serious infections in patients receiving anti-tumor necrosis factor and other newly approved biologic therapies: case finding through the Emerging Infections NetworkKevin L Winthrop
Oregon Health and Sciences University, Portland 97239, USA
Clin Infect Dis 46:1738-40. 2008..Nontuberculous mycobacterial infections, histoplasmosis, and invasive Staphylococcus aureus infection were all reported more frequently than was tuberculosis disease in this context...
- The new mycobacteria: an updateEnrico Tortoli
Regional Reference Centre for Mycobacteria, Careggi Hospital, Florence, Italy
FEMS Immunol Med Microbiol 48:159-78. 2006..The aim of this present update is to provide epidemiological and clinical information along with major phenotypic and genotypic characteristics of the species described in the last 3 years...
- Genetic dissection of immunity to mycobacteria: the human modelJean Laurent Casanova
Laboratory of Human Genetics of Infectious Diseases, Université René Descartes INSERM U550, Necker Medical School, 156 rue de Vaugirard, 75015 Paris, France
Annu Rev Immunol 20:581-620. 2002..The human model has potential uses beyond the study of mycobacterial infections and may well become a model of choice for the investigation of immunity to infectious agents...
- Differentiation of mycobacterial species by PCR-restriction analysis of DNA (342 base pairs) of the RNA polymerase gene (rpoB)B J Kim
Department of Microbiology, Cheju National University College of Medicine, Cheju 690-7561
J Clin Microbiol 39:2102-9. 2001..These results suggest that PRA of rpoB DNA is a simple and feasible method not only for the differentiation of culture isolates but also for the rapid detection and identification of pathogenic mycobacteria in primary clinical specimens...
- A role for dendritic cells in the dissemination of mycobacterial infectionIan R Humphreys
Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Microbes Infect 8:1339-46. 2006..The results are consistent with a model in which mycobacterial dissemination from the lung is initiated by the migration of infected dendritic cells to the draining lymph nodes...
- Immune gene networks of mycobacterial vaccine-elicited cellular responses and immunityDan Huang
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois at Chicago, IL, 60612, USA
J Infect Dis 195:55-69. 2007..These findings provide molecular evidence suggesting that the BCG-induced gene networks may represent global transcriptomes and proteomes underlying the development of T cell responses and, ultimately, immunity to mycobacteria...
- Factors associated with pastoral community knowledge and occurrence of mycobacterial infections in human-animal interface areas of Nakasongola and Mubende districts, UgandaClovice Kankya
Department of Veterinary Public Health, Faculty of Veterinary Medicine Makerere University, P, O, Box 7062, Kampala, Uganda
BMC Public Health 10:471. 2010....
- Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiencyStephanie Dupuis
Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM UMR550, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
Nat Genet 33:388-91. 2003..Viral multiplication was not inhibited by recombinant IFN-alpha/beta in cell lines from the two individuals. Inherited impairment of the STAT1-dependent response to human IFN-alpha/beta thus results in susceptibility to viral disease...
- Detection of mixed infections with Mycobacterium lentiflavum and Mycobacterium avium by molecular genotyping methodsPhilip Suffys
Department of Mycobacterioses, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
J Med Microbiol 55:127-31. 2006..At the time of detection, both cases were also infected with M. avium, suggesting an underestimation of infection with M. lentiflavum and co-infection with different Mycobacterium species...
- Acute respiratory failure involving an R variant of Mycobacterium abscessusEmilie Catherinot
Laboratoire de Microbiologie, AP HP, Hôpital Raymond Poincaré et Hôpital Ambroise Paré, and Université de Versailles Saint Quentin en Yvelines, EA3647, Garches, France
J Clin Microbiol 47:271-4. 2009..This report emphasizes the role of R forms in severe M. abscessus infections...
- BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular methodSo Hee Kim
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
Vaccine 26:4379-81. 2008..The isolates were identified as BCG Tokyo strains by the deletion of the region of difference 1 (RD1) and characterization of RD8 and RD14 using the multiplex polymerase chain reaction...
- Mycobacterium riyadhense sp. nov., a non-tuberculous species identified as Mycobacterium tuberculosis complex by a commercial line-probe assayJakko van Ingen
National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Int J Syst Evol Microbiol 59:1049-53. 2009..We propose the name Mycobacterium riyadhense sp. nov. to accommodate this strain. The type strain is NLA000201958(T) (=CIP 109808(T) =DSM 45176(T))...
- Mycobacterial granulomas: keys to a long-lasting host-pathogen relationshipDominic O Co
Program in Cellular and Molecular Biology, University of Wisconsin Madison, 53706, USA
Clin Immunol 113:130-6. 2004....
- Anti-interferon-γ autoantibody and opportunistic infections: case series and review of the literatureT Kampitak
Division of Allergy and Clinical Immunology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Infection 39:65-71. 2011..Two patients also developed Sweet's syndrome during the course of infections. In addition, we also review all previous reports of patients with anti-IFN-γ antibodies who were susceptible to NTM and Salmonella infections...
- Mycobacterium wolinskyi sp. nov. and Mycobacterium goodii sp. nov., two new rapidly growing species related to Mycobacterium smegmatis and associated with human wound infections: a cooperative study from the International Working Group on Mycobacterial TaB A Brown
Department of Microbiology, University of Texas Health Center at Tyler 75708 3154, USA
Int J Syst Bacteriol 49:1493-511. 1999..nov. for group 2 isolates (type strain ATCC 700504T = MO69T), Mycobacterium wolinskyi sp. nov. for group 3 isolates (type strain ATCC 700010T = MO739T) and Mycobacterium smegmatis sensu stricto for group 1 isolates...
- A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretionLian Yong Gao
Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
Mol Microbiol 53:1677-93. 2004..marinum homologue of Rv3881c, not previously implicated in virulence, led to a much more attenuated phenotype in macrophages and in vivo, suggesting that this gene plays additional roles in M. marinum survival in the host...
- Mycobacterium abscessus and other nontuberculous mycobacteria: evolving respiratory pathogens in cystic fibrosis: a case report and reviewDon Hayes
Department of Medicine and Pediatrics, University of Wisconsin Medical School, Clinical Sciences Center, Madison, WI 53792, USA
South Med J 98:657-61. 2005..As more is discovered about NTM, the pathogenicity and virulence of these organisms should be considered in the setting of CF and treated...
- rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. novToidi Adekambi
Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, 27, Boulevard Jean Moulin, Université de la Méditerranée and Assistance Publique Hôpitaux de Marseille Timone, Fédération de Microbiologie Clinique, Marseille, France
Int J Syst Evol Microbiol 56:133-43. 2006....
- Human immunodeficiencies that predispose to intracellular bacterial infectionsRainer Doffinger
Department of Clinical Biochemistry and Immunology, Cambridge, United Kingdom
Curr Opin Rheumatol 17:440-6. 2005..This review addresses the effects of inherited and acquired immunodeficiencies on the susceptibility to the development of intracellular bacterial infections...
- An oxidative environment promotes growth of Mycobacterium abscessusRebecca E Oberley-Deegan
Department of Medicine, National Jewish Health, Denver, CO 80206, USA
Free Radic Biol Med 49:1666-73. 2010..abscessus growth is inhibited. These results lead us to postulate that antioxidants may aid in the treatment of M. abscessus infections...
- [Nontuberculous mycobacterial infection in patients with cystic fibrosis: a multicenter prevalence study]Rosa M Girón
Unidad de fibrosis quistica, Hospital de la Princesa, Madrid, Espana
Arch Bronconeumol 44:679-84. 2008..To determine the prevalence of nontuberculous mycobacterial infection in patients with cystic fibrosis...
- Anti-CD20 (rituximab) therapy for anti-IFN-γ autoantibody-associated nontuberculous mycobacterial infectionSarah K Browne
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 119:3933-9. 2012....
- Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variantsAnne Laure Roux
EA 3647 Physiopathologie et diagnostic des infections microbiennes, Universite Versailles St Quentin, and Laboratoire de Microbiologie, Hopital Raymond Poincare, AP HP, Garches, France
Cell Microbiol 13:692-704. 2011..In conclusion, R morphotype in M. abscessus is associated with increased synthesis/exposure at the cell surface of lipoproteins, these changes profoundly modifying the innate immune response through TLR-2-dependent mechanisms...
- Pulmonary infections associated with non-tuberculous mycobacteria in immunocompetent patientsClaudio Piersimoni
Department of Clinical Microbiology, United Hospitals, Ancona, Italy
Lancet Infect Dis 8:323-34. 2008..We discuss the epidemiological features, clinical syndromes, and developments in the investigation, prevention, and treatment of pulmonary non-tuberculous mycobacterial infections...
- Identification of Mycobacterium spp. of veterinary importance using rpoB gene sequencingJames Higgins
Mycobacteria and Brucella Section, National Veterinary Services Laboratories, USDA APHIS, 1920 Dayton Ave, Ames, IA 50010, USA
BMC Vet Res 7:77. 2011..Given that MAC are important pathogens in livestock, companion animals, and zoo/exotic animals, we were interested in evaluating the use of rpoB sequencing for identification of Mycobacterium isolates of veterinary origin...
- Mycobacterial species diversity at a general hospital on the island of Crete: first detection of Mycobacterium lentiflavum in GreeceIoannis K Neonakis
Mycobacteriology Laboratory, Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, 712 01 Heraklion, Crete, Greece
Scand J Infect Dis 39:875-9. 2007..All strains exhibited multidrug resistance. The patients were adults with immunosuppression or predisposing conditions for NTM infection. Diagnosis of true infection was either not pursued or the patients died shortly after isolation...
- Cervical lymphadenitis caused by Mycobacterium lentiflavumFroilán Cabria
Department of Medical Microbiology, Fundacion Jimenez Diaz, Madrid, Spain
Pediatr Infect Dis J 21:574-5. 2002..The patient was a 19-month-old boy with involvement of a cervical lymph node. Surgical removal of the lymphadenopathy was both diagnostic and curative...
- Isolation and automated ribotyping of Mycobacterium lentiflavum from drinking water distribution system and clinical specimensIrina Tsitko
Department of Applied Chemistry and Microbiology, National Public Health Institute, Turku, Finland
FEMS Microbiol Lett 256:236-43. 2006..The drinking water distribution system may, thus, be a source of nontuberculous mycobacteria resistant to multiple drugs...
- Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasiaDonald C Vinh
Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 115:1519-29. 2010..This novel clinical syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern...
- Enterobacterial repetitive intergenic consensus PCR is a useful tool for typing Mycobacterium chelonae and Mycobacterium abscessus isolatesJorge Luiz Mello Sampaio
Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862 3 andar 04023 062, Sao Paulo, Brazil
Diagn Microbiol Infect Dis 55:107-18. 2006..chelonae-abscessus group...
- Cutaneous infection by Mycobacterium lentiflavum in a patient with HIVMiguel Montejo
Dermatology 213:173-4. 2006
- Disseminated Mycobacterium lentiflavum infection in a human immunodeficiency virus-infected patientS N Niobe
, , , 33076 Bordeaux Cedex, France
J Clin Microbiol 39:2030-2. 2001..Furthermore, we describe here the analysis of the 16S-23S rRNA internal transcribed spacer sequence of M. lentiflavum...
- Changing epidemiology of pulmonary nontuberculous mycobacteria infectionsRachel M Thomson
Queensland Tuberculosis Control Centre, Brisbane, Queensland, Australia
Emerg Infect Dis 16:1576-83. 2010..Mycobacterium intracellulare is the main pathogen associated with the increase in isolates speciated in Queensland...
- Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinantHannah E Volkman
Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA
PLoS Biol 2:e367. 2004..This Mycobacterium-induced macrophage aggregation in turn is tightly linked to intercellular bacterial dissemination and increased bacterial numbers. Thus, mycobacteria co-opt host granulomas for their virulence...
- [Mycobacterium lentiflavum infection: case history and review of the medical literature]Maria Jose Uria
Enferm Infecc Microbiol Clin 21:274-5. 2003
- Characterization of mycobacterial isolates phylogenetically related to, but different from Mycobacterium simiaeE Tortoli
Laboratory of Microbiology and Virology, Careggi Hospital, Firenze, Italy
J Clin Microbiol 35:697-702. 1997..Sophisticated techniques, like genetic sequencing or HPLC, by now seem indispensable for differentiating unusual and new mycobacteria from well-established ones...
- Mycobacterium lentiflavum, an emerging pathogen?Enrico Tortoli
Microbiology and Virology Laboratory, Regional Reference Center for Mycobacteria, Careggi Hospital, 50134 Florence, Italy
J Infect 52:e185-7. 2006....
- The secret lives of the pathogenic mycobacteriaChristine L Cosma
Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
Annu Rev Microbiol 57:641-76. 2003..In addition, we highlight current controversies and unanswered questions in these areas...
- Immune restoration disease after antiretroviral therapyMartyn A French
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
AIDS 18:1615-27. 2004..Investigation of strategies to prevent IRD is a priority, particularly in developing countries, and requires the development of risk assessment methods and diagnostic criteria...
- Mycobacteria causing human cervical lymphadenitis in pastoral communities in the Karamoja region of UgandaJ Oloya
Department of Veterinary Public Health and Preventive Medicine, Makerere University, Kampala, Uganda
Epidemiol Infect 136:636-43. 2008..Isolation of environmental mycobacteria also confirms their increasing role in human disease and the occupational risk of infection in the transhumant ecosystem in the absence of safe drinking water and environmental contamination...
- Increasing reports of non-tuberculous mycobacteria in England, Wales and Northern Ireland, 1995-2006Jonathan E Moore
Health Protection Agency Centre for Infections, Respiratory Diseases Department Tuberculosis Section, 61 Colindale Avenue, London NW9 5EQ, UK
BMC Public Health 10:612. 2010..We investigated recent trends in, and the epidemiology of, non-tuberculous mycobacterial infections in England, Wales and Northern Ireland, 1995-2006...
- Nontuberculous mycobacterial immune reconstitution syndrome in HIV-infected patients: spectrum of disease and long-term follow-upPeter Phillips
Division of Infectious Diseases, St Paul s Hospital, Vancouver, British Columbia, Canada
Clin Infect Dis 41:1483-97. 2005..The long-term outcome and spectrum of disease of nontuberculous mycobacterial immune reconstitution syndrome have not been described...
- Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1Dong Min Shin
Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
Cell Microbiol 10:1608-21. 2008..Collectively, these data demonstrate that Mab actively internalizes into and robustly activates innate immune responses in macrophages through a physical and functional interaction between TLR2 and dectin-1...
- Spectrum of CNS disease caused by rapidly growing mycobacteriaNaasha J Talati
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA
Lancet Infect Dis 8:390-8. 2008..Treatment requires a long course of two or more antibiotics that have the ability to penetrate the blood-brain barrier, and possibly of steroids as immunomodulatory agents, such as those used in tuberculous meningitis...
- TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infectionDaniel R Roach
Centenary Institute of Cancer Medicine and Cell Biology, Newton, Sydney, New South Wales, Australia
J Immunol 168:4620-7. 2002..Therefore, TNF orchestrates early induction of chemokines and initial leukocyte recruitment, but has an additional role in the aggregation of leukocytes into functional granulomas capable of controlling virulent mycobacterial infection...
- Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted miceI Sugawara
Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo 204 0022, Japan
Infect Immun 67:2585-9. 1999..Therefore, IL-18 is important for the generation of protective immunity to mycobacteria, and its main function is the induction of IFN-gamma expression...
- Human infections due to Mycobacterium lentiflavumEnrico Tortoli
Regional Reference Center for Mycobacteria, Microbiology and Virology Laboratory, Careggi Hospital, Italy
J Clin Microbiol 40:728-9. 2002..In the first, the mycobacterium was responsible for chronic pulmonary disease in an elderly woman; in the second, it gave rise to cervical lymphadenitis in a child; and in the third, it caused a liver abscess in a young AIDS patient...
- Identification of an emerging pathogen, Mycobacterium massiliense, by rpoB sequencing of clinical isolates collected in the United StatesKeith E Simmon
Associated Regional and University Pathologists ARUP Instititue for Clincal and Experimental Pathology, Salt Lake City, UT 84108, USA
J Clin Microbiol 45:1978-80. 2007..chelonae/M. abscessus and identified M. massiliense from isolates from two patients with invasive disease representing the first reported cases in the United States...
- Environmental sources of rapid growing nontuberculous mycobacteria causing disease in humansJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Clin Microbiol Infect 15:888-93. 2009..Furthermore, studies should focus on the actual sites of the active replication of RGM; their presence may not indicate their natural habitat...
- Mycobacterium sherrisii: a new opportunistic agent in HIV infection?Pierre Loulergue
AIDS 21:893-4. 2007
- Interferon-gamma release assays improve the diagnosis of tuberculosis and nontuberculous mycobacterial disease in children in a country with a low incidence of tuberculosisA K Detjen
Department of Pediatric Pneumology and Immunology, Charite University Medical Center, Berlin, Germany
Clin Infect Dis 45:322-8. 2007..We assessed the diagnostic accuracy of IGRAs for TB in children in an area with a low incidence of TB...
- Characterization of an unusual Mycobacterium: a possible missing link between Mycobacterium marinum and Mycobacterium ulceransK Chemlal
Department of Microbiology, Mycobacteriology Unit, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
J Clin Microbiol 40:2370-80. 2002..Jenkin, P. D. Johnson, and J. K. Davies, J. Bacteriol. 182:6322-6330, 2000) that M. ulcerans represents a relatively recent phylogenetic derivative of M. marinum resulting from the systematic acquisition of foreign DNA fragments...
- Emergence of Mycobacterium simiae in respiratory specimensZmira Samra
Departmnent of Clinical Microbiology, Rabin Medical Centre, Beilinson Campus, Sackler Faculty of Medicine, Israel
Scand J Infect Dis 37:838-41. 2005..9% to 7.5%; and Mycobacterium haemophilum 1.2% to 0%). These findings disclose major temporal changes in the distribution of mycobacterial species in respiratory specimens with an impressive emergence and takeover of M. simiae...
- Mycobacterium haemophilum and lymphadenitis in childrenLesla E S Bruijnesteijn van Coppenraet
Leiden University Medical Center, Leiden, The Netherlands
Emerg Infect Dis 11:62-8. 2005..haemophilum was the second most commonly recognized pathogen. Real-time PCR results were superior to culture because only 9 (56%) of the 16 diagnosed M. haemophilum infections were positive by culture...
- Controlled comparison of BACTEC 13A, MYCO/F LYTIC, BacT/ALERT MB, and ISOLATOR 10 systems for detection of mycobacteremiaJohn A Crump
Clinical Microbiology Laboratory, Duke University Medical Center and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
J Clin Microbiol 41:1987-90. 2003....
- Identification of Mycobacterium spp. by using a commercial 16S ribosomal DNA sequencing kit and additional sequencing librariesJ L Cloud
Associated Regional and University Pathologists ARUP, Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
J Clin Microbiol 40:400-6. 2002....
- Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected miceR Reljic
Department for Oral Medicine and Pathology, Guy s Campus of King s College, London, UK
Tuberculosis (Edinb) 85:81-8. 2005..In this paper we investigated if their early infection in the lungs represents a plausible alternative to cross-priming with mycobacterial antigens acquired from infected macrophages...
- Mycobacterium simae outbreak associated with a hospital water supplyNicholas G Conger
Department of Infectious Disease, Wilford Hall Medical Center, Lackland AFB, Texas, USA
Infect Control Hosp Epidemiol 25:1050-5. 2004..Our institution saw an increase in M. simiae isolates in 2001. An investigation into possible contaminated water sources was undertaken...
- Mycobacteriosis in patients with fever of unknown originChuen Chin
Section of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC
J Microbiol Immunol Infect 36:248-53. 2003..In conclusion, mycobacteriosis remains the leading cause of FUO in southern Taiwan and it is important to screen for this treatable disease in all cases of FUO...
- Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humansM A Saubolle
Department of Pathology, Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA
Clin Microbiol Rev 9:435-47. 1996..The organisms are most susceptible to ciprofloxacin, clarithromycin, rifabutin, and rifampin. Timely diagnosis and therapy require communication between clinician and the laboratory...
- Application of the Sherlock Mycobacteria Identification System using high-performance liquid chromatography in a clinical laboratoryJ A Kellogg
Clinical Microbiology Laboratory, York Hospital, York, PA 17405, USA
J Clin Microbiol 39:964-70. 2001..The SMIS, combined with knowledge of RPHRs, RRTs, and phenotypic characteristics, offers a rapid, reasonably accurate, cost-effective alternative to more traditional methods of mycobacterial species identification...
- Novel diagnostic algorithm for identification of mycobacteria using genus-specific amplification of the 16S-23S rRNA gene spacer and restriction endonucleasesA Roth
Institut für Mikrobiologie und Immunologie, Lungenklinik Heckeshorn, 14109 Berlin, Germany
J Clin Microbiol 38:1094-104. 2000....
- Cutaneous Mycobacterium haemophilum infections in immunocompromised patients in a dermatology clinic in SingaporeH H Tan
National Skin Centre, 1 Mandalay Road, Singapore 308205
Ann Acad Med Singapore 33:532-6. 2004..Mycobacterium haemophilum, a nontuberculous mycobacterium (NTM) that was first described in 1978, is a pathogen that can cause an array of symptoms in immunocompromised patients, predominantly cutaneous...
- Macrophage signalling upon mycobacterial infection: the MAP kinases lead the wayJeffrey S Schorey
University of Notre Dame, Department of Biology and Center of Tropical Disease Research and Training, 130 Galvin Life Science Center, Notre Dame, IN 46556, USA
Cell Microbiol 5:133-42. 2003..Therefore, the ability of pathogenic mycobacteria to limit MAPK activity is likely an important virulence mechanism and may be a potential therapeutic target...
- Two decades of disseminated tuberculosis at a university medical center: the expanding role of mycobacterial blood cultureJohn A Crump
Clinical Microbiology Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Infect Dis 37:1037-43. 2003..Mycobacterial blood culture can play an increasing role in the diagnosis of disseminated tuberculosis when localized disease is not found...
- Non-tuberculous mycobacteria I: one year clinical isolates identification in Tertiary Hospital Aids Reference Center, Rio de Janeiro, Brazil, in pre highly active antiretroviral therapy eraRosa Maria Carvalho Ferreira
Laboratorio de Micobacterias, Hospital Evandro Chagas
Mem Inst Oswaldo Cruz 97:725-9. 2002..Some discrepancies were seen between the identification methods and further investigations must be done to better characterize NTM isolates using other phenotypic and genotypic methods...
- Fatal pulmonary infection with Mycobacterium celatum in an apparently immunocompetent patientI Bux-Gewehr
I Medizinische Klinik, DRK Krankenhaus Neuwied, Germany
J Clin Microbiol 36:587-8. 1998..We present here, to our knowledge, the first report of a fatal pulmonary infection caused by M. celatum in a 73-year-old immunocompetent female patient. The mycobacterium was identified by a 16S rRNA sequence analysis...
- Alveolar macrophage and mycobacteriaRajamouli Pasula; Fiscal Year: 2007..abstract_text> ..
- Cell Biology of Mycobacterium tuberculosis InfectionDavid G Russell; Fiscal Year: 2010..tuberculosis. We propose determining how the bacterium's metabolism is realigned to access these carbon sources. ..
- LUNG SPECIFIC DELIVERY OF OLIGONUCLEOTIDESJeffrey Hughes; Fiscal Year: 1999..are to create nucleic acid specific delivery systems for the successful treatment of lung resident mycobacterium infections. Mycobacterium tuberculosis (TB) infections are one of most common causes of bacterial related death ..
- Molecular analysis of frozen sarcoidosis granulomasWonder Drake; Fiscal Year: 2004..The pathologic, epidemiologic, and immunologic features of sarcoidosis are similar to Mycobacterium infections, particularly tuberculosis...
- Molecular analysis of frozen sarcoidosis granulomasWonder Drake; Fiscal Year: 2005..The pathologic, epidemiologic, and immunologic features of sarcoidosis are similar to Mycobacterium infections, particularly tuberculosis...
- OPTICAL SENSOR FOR MYCOBACTERIUM DETERMINATONBernard Schneider; Fiscal Year: 1999..PROPOSED COMMERCIAL APPLICATIONS: Mycobacterium infections, and tuberculosis in particular, are a major cause of infectious disease-related death on a worldwide ..
- Mentoring in Tuberculosis Patient-Oriented ResearchNeil Schluger; Fiscal Year: 2008..abstract_text> ..
- Mentoring in Tuberculosis Patient-Oriented ResearchNeil Schluger; Fiscal Year: 2007..abstract_text> ..
- Training in Translational Lung ResearchNeil Schluger; Fiscal Year: 2007..abstract_text> ..
- Training in Translational Lung ResearchNeil Schluger; Fiscal Year: 2008..abstract_text> ..
- STRUCTURE OF LAM IN RELATION TO BIOLOGY AND BIOSYNTHESISDelphi Chatterjee; Fiscal Year: 2007..smegmatis and M. tuberculosis all in relation to biology and biosynthesis. ..
- Environmental cues and responses in tuberculosisDavid Russell; Fiscal Year: 2007....
- Role of Macrophage Arginase in Anti-Bacterial ImmunityPeter Murray; Fiscal Year: 2007..The outcomes of the proposed studies will reveal new elements of Arg I function and provide rationale for approaching Arg I as a target in inflammatory diseases. ..
- The role of IL-12p40 in the response of pulmonary dendritic cells to tuberculosisAndrea Cooper; Fiscal Year: 2006..This increased understanding will allow targeted and novel interventions that will improve our ability to control disease. ..
- Investigation of the role of bacteria in the sarcoidosis trimolecular complexWonder Drake; Fiscal Year: 2006....
- CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIESMichael Kent; Fiscal Year: 2006..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
- Macrophage signaling upon M avium infectionJeffrey Schorey; Fiscal Year: 2006..avium pathogenesis and in macrophage activation. We will use a combination of genetic, immunological and cell biological approaches to address these important questions. ..
- CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIESMichael Kent; Fiscal Year: 2004..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
- Development of a Novel Strategy of Adjuvant DiscoveryDavid Russell; Fiscal Year: 2005..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
- Host defense functions of M. tuberculosis lipoglycanEdward Chan; Fiscal Year: 2005..3. To elucidate the role of the TLRs, MAPK and NFkB signaling pathways, and ManLAM in controlling the growth of M. tuberculosis in mouse and human macrophages and to correlate effects on growth with NO* and TNFa expression. ..
- Zeiss LSM510 Meta Confocal MicroscopeDavid Russell; Fiscal Year: 2007..These data will extend ongoing, NIH-funded programs for identification of new drug targets, vaccines and adjuvants. [unreadable] [unreadable] [unreadable]..
- Investigation of the role of bacteria in the sarcoidosis trimolecular complexWonder Drake; Fiscal Year: 2007....
- Role of mycobacteria in sarcoidosis immunopathogenesisWonder Drake; Fiscal Year: 2009..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..
- T cell memory to TB in the lungAndrea M Cooper; Fiscal Year: 2010..These new cell types may improve the protective effect of vaccines and thereby reduce the incidence of tuberculosis in the world. This will have a significant impact in worldwide public health. ..
- Enviromental cues and responses in tuberculosisDavid G Russell; Fiscal Year: 2010..abstract_text> ..
- Development of a cell-based HTS for compounds with activity against tuberculosisDavid Russell; Fiscal Year: 2009..tuberculosis, which can then be used to develop new drugs or combinations of drugs to more effectively treat this disease. ..
- Secretory Phospholipase A2s in Airway PathophysiologyTEAL HALLSTRAND; Fiscal Year: 2009..Our goal is to determine the function of the sPLA2s in asthma so that novel therapies can be developed and tested in clinical trials that will improve the effectiveness of asthma treatments and alter the natural history of asthma. ..
- Development of a Novel Strategy of Adjuvant DiscoveryDavid Russell; Fiscal Year: 2009..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
- Non-Antibiotic Selectable Markers for Bacillus AnthracisJames Kirby; Fiscal Year: 2008..These new tools will be safer for researchers and the public, accelerate discovery, and find broad use in investigation of a wide range of infectious organisms. ..
- Traffic from chronic mycobacterium induced granulomasMatyas Sandor; Fiscal Year: 2008..These experiments will increase our understanding of other infectious and autoimmune granulomatous diseases and their long- term immunopathologies. ..
- Secretory Phospholipase A2s in Airway PathophysiologyTEAL HALLSTRAND; Fiscal Year: 2008..Our goal is to determine the function of the sPLA2s in asthma so that novel therapies can be developed and tested in clinical trials that will improve the effectiveness of asthma treatments and alter the natural history of asthma. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2008..New knowledge of how T cells regulate granulomas will lead to more efficient therapeutic manipulations of granulomatous diseases. ..
- Investigation of the role of bacteria in the sarcoidosis trimolecular complexWonder Drake; Fiscal Year: 2008..abstract_text> ..
- Macaque Models of AIDS-Related Tuberculosis and T CellZheng Chen; Fiscal Year: 2008..unreadable] [unreadable] III. Determine the utility of vaccination of V?2Vd2 T cells in delay or prevention of tuberculosis in immune competent and SHIV-infected monkeys. [unreadable] [unreadable]..
- Impact of chronic infection in the aged on the response to vaccinationAndrea Cooper; Fiscal Year: 2007..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. [unreadable] [unreadable] [unreadable] [unreadable]..
- Immunotherapeutics and vaccines against anthrax, plague and tularemiaZheng Chen; Fiscal Year: 2007....
- M. avium GPLs in macrophage activation and virulenceJeffrey Schorey; Fiscal Year: 2005..We believe a more careful analysis of these macrophage responses and how mycobacteria may modify them will lead to novel insights into mycobacterial pathogenesis. ..
- Macaque Models of AIDS-Related Tuberculosis and T CellZheng Chen; Fiscal Year: 2004..III. Determine the utility of vaccination of V?2Vd2 T cells in delay or prevention of tuberculosis in immune competent and SHIV-infected monkeys. ..
- CONTROL OF DISEASE IN ZEBRAFISH RESEARCH FACILITIESMichael Kent; Fiscal Year: 2003..In addition, the investigators have developed a Web-based fish health manual, and new information generated in the present study will be incorporated into this manual. ..
- Role of SOCS proteins in host-pathogen responsesPeter Murray; Fiscal Year: 2003..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
- GENES ASSOCIATED WITH M AVIUM PATHOGENESISLuiz Bermudez; Fiscal Year: 2002..The applicants believe that the studies outlined in this proposal will provide excellent tools for the identification of novel genes associated with mechanisms of pathogenesis of M. avium.m. ..
- THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONSDavid Russell; Fiscal Year: 2001..The BAL cells will also be examined in cell migration assays based on the result from the murine granuloma model described in aim # 2...
- MACAQUE MODEL OF AIDS VIRUS-RELATED PULMONARY TUBERCULOSZheng Chen; Fiscal Year: 2001..III. Determine the utility of antiretrovirals for restoring anti-BCG pulmonary T-cell immunity in SIV-infected monkeys. ..
- IMMUNOPATHOGENESIS OF MYCOBACTERIUM AVIUM DISEASEAndrea Cooper; Fiscal Year: 2001..Finally, they will test the hypothesis that appropriate chemotherapy can restore the correct immunologic functions/signals, using both established regimens, as well as new compounds recently identified in their laboratory as active. ..
- MODEL OF AIDS VIRUS-RELATED PULMONARY TUBERCULOSISZheng Chen; Fiscal Year: 2000..III. Determine the utility of antiretrovirals for restoring anti-BCG pulmonary T-cell immunity in SIV-infected monkeys. ..
- THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONSDavid Russell; Fiscal Year: 2002..The BAL cells will also be examined in cell migration assays based on the result from the murine granuloma model described in aim # 2...
- GENETIC DISSECTION OF MYCOBACTERIAL INFECTIONErwin Schurr; Fiscal Year: 2002..tuberculosis through an exposed population. ..
- GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPPDavid Russell; Fiscal Year: 2001..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
- TB LAM AND AG--STRUCTURES CORRELATED WITH BIOLOGYDelphi Chatterjee; Fiscal Year: 2001..tuberculosis. The structural studies will directly aid the immunological studies by providing a wealth of LAM related molecules needed to decipher the structural characteristics necessary for recognition by T-cells and macrophages. ..
- Mycobacterial antigen compartmentalization & immunityMatyas Sandor; Fiscal Year: 2002..abstract_text> ..
- GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPPDavid Russell; Fiscal Year: 2004..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2000..abstract_text> ..
- SIV/MYCOBACTERIUM COINFECTIONZheng Chen; Fiscal Year: 2001..II. CD4+ responses in BCG-infected and SIV/BCG coinfected monkeys. III. CD8+ responses in BCG-infected and SIV/BCG infected monkeys. IV. T gd+ cell responses in BCG-infected and SIV/BCG coinfected monkeys. ..
- Genes Associated with M .avium PathogenesisLuiz Bermudez; Fiscal Year: 2004..An initial screen of 3000 mutants resulted in the identification of a number of virulent determinants, such as PPE genes, polyketide synthases, MmpL proteins, ABC transporters, and several genes of unknown function. ..
- Secondary infections during mycobacterial diseaseMatyas Sandor; Fiscal Year: 2004..The goal of this research is to understand the interaction of T cell responses controlling different infections. Hopefully, this will lead to better treatments of mycobacterial disease. ..
- M. avium GPLs in macrophage activation and virulenceJeffrey Schorey; Fiscal Year: 2004..We believe a more careful analysis of these macrophage responses and how mycobacteria may modify them will lead to novel insights into mycobacterial pathogenesis. ..
- Host defense functions of M. tuberculosis lipoglycanEdward Chan; Fiscal Year: 2002..3. To elucidate the role of the TLRs, MAPK and NFkB signaling pathways, and ManLAM in controlling the growth of M. tuberculosis in mouse and human macrophages and to correlate effects on growth with NO* and TNFa expression. ..
- TB LAM AND AG--STRUCTURES CORRELATED WITH BIOLOGYDelphi Chatterjee; Fiscal Year: 1999..tuberculosis. The structural studies will directly aid the immunological studies by providing a wealth of LAM related molecules needed to decipher the structural characteristics necessary for recognition by T-cells and macrophages. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2001..abstract_text> ..
- TB LAM AND AG--STRUCTURES CORRELATED WITH BIOLOGYDelphi Chatterjee; Fiscal Year: 2000..tuberculosis. The structural studies will directly aid the immunological studies by providing a wealth of LAM related molecules needed to decipher the structural characteristics necessary for recognition by T-cells and macrophages. ..
- FLAGELLAR POCKET OF LEISHMANIADavid Russell; Fiscal Year: 2000..abstract_text> ..
- STRUCTURE OF LAM IN RELATION TO BIOLOGY AND BIOSYNTHESISDelphi Chatterjee; Fiscal Year: 2004..smegmatis and M. tuberculosis all in relation to biology and biosynthesis. ..
- The Link Between Anemia of Inflammation and Host DefenseSeth Rivera; Fiscal Year: 2008..The research has broad relevance to the management of Al during severe infections. ..
- The Link Between Anemia of Inflammation and Host DefenseSeth Rivera; Fiscal Year: 2007..The research has broad relevance to the management of Al during severe infections. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2010..New knowledge of how T cells regulate granulomas will lead to more efficient therapeutic manipulations of granulomatous diseases. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2009..New knowledge of how T cells regulate granulomas will lead to more efficient therapeutic manipulations of granulomatous diseases. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2010
- GENETIC DISSECTION OF MYCOBACTERIAL INFECTIONErwin Schurr; Fiscal Year: 2001..tuberculosis through an exposed population. ..
- GENETIC DISSECTION OF MYCOBACTERIAL INFECTIONErwin Schurr; Fiscal Year: 2005..tuberculosis through an exposed population. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2004..abstract_text> ..
- BD LSR II Blue Laser Flow cytometerMatyas Sandor; Fiscal Year: 2006..A new generation of flow cytometric assays is becoming available and our group of users would like to advance to the next level. [unreadable] [unreadable]..
- Mycobacterial antigen compartmentalization & immunityMatyas Sandor; Fiscal Year: 2005..abstract_text> ..
- Mycobacterial antigen compartmentalization & immunityMatyas Sandor; Fiscal Year: 2004..abstract_text> ..
- Alveolar macrophage and mycobacteriaRajamouli Pasula; Fiscal Year: 2006..abstract_text> ..
- The Basis of Anthrax-Induced Vascular DamageJames Kirby; Fiscal Year: 2006..As part of this exploration, we hope to identify and test new therapeutic strategies. [unreadable] [unreadable]..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2003..abstract_text> ..
- Mycobacterial antigen compartmentalization & immunityMatyas Sandor; Fiscal Year: 2003..abstract_text> ..
- GENETIC DISSECTION OF MYCOBACTERIAL INFECTIONErwin Schurr; Fiscal Year: 2003..tuberculosis through an exposed population. ..
- Alveolar macrophage and mycobacteriaRajamouli Pasula; Fiscal Year: 2005..abstract_text> ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2002..abstract_text> ..
- GENETIC DISSECTION OF MYCOBACTERIAL INFECTIONErwin Schurr; Fiscal Year: 2004..tuberculosis through an exposed population. ..
- Role of non-tuberculous mycobacteria in lung diseaseJason Stout; Fiscal Year: 2006..Our findings will also assist clinicians in predicting which patients with NTM isolated from the respiratory tract will have NTM pulmonary disease. ..