mycobacterium infections

Summary

Summary: Infections with bacteria of the genus MYCOBACTERIUM.

Top Publications

  1. pmc Mycobacterium lentiflavum infection in immunocompetent patient
    Chiara Molteni
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    Emerg Infect Dis 11:119-22. 2005
  2. pmc Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletii
    Adrian M Zelazny
    Microbiology Service, Department of Laboratory Medicine, NIAD, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Microbiol 47:1985-95. 2009
  3. ncbi An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
    David E Griffith
    Am J Respir Crit Care Med 175:367-416. 2007
  4. doi Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiology
    P Maureen Cassidy
    Department of Human Services, Oregon Public Health Division, Portland, USA
    Clin Infect Dis 49:e124-9. 2009
  5. pmc Molecular characterization of Mycobacterium massiliense and Mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic procedures
    Cristina Viana-Niero
    Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Departamento de Microbiologia, Imunologia e Parasitologia, Rua Botucatu, 862, São Paulo 04023 062, Brazil
    J Clin Microbiol 46:850-5. 2008
  6. ncbi PCR restriction fragment length polymorphism analysis (PRA)-algorithm targeting 644 bp Heat Shock Protein 65 (hsp65) gene for differentiation of Mycobacterium spp
    Hong Kim
    Department of Microbiology and Liver Research Institute, College of Medicine, Seoul National University, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    J Microbiol Methods 62:199-209. 2005
  7. doi Innate response of human endothelial cells infected with mycobacteria
    Blanca Estela García-Pérez
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Prolongacion de Carpio y Plan de Ayala S N, Z P 11340, Mexico, D F, Mexico
    Immunobiology 216:925-35. 2011
  8. pmc Multicenter cross-sectional study of nontuberculous mycobacterial infections among cystic fibrosis patients, Israel
    Isaac Levy
    Sheba Medical Center, Tel Hashomer, Israel
    Emerg Infect Dis 14:378-84. 2008
  9. pmc Amoebal coculture of "Mycobacterium massiliense" sp. nov. from the sputum of a patient with hemoptoic pneumonia
    Toidi Adekambi
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, Université de la Méditteranée, Marseille, France
    J Clin Microbiol 42:5493-501. 2004
  10. pmc Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003
    Theodore K Marras
    Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Canada
    Thorax 62:661-6. 2007

Research Grants

Detail Information

Publications228 found, 100 shown here

  1. pmc Mycobacterium lentiflavum infection in immunocompetent patient
    Chiara Molteni
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    Emerg Infect Dis 11:119-22. 2005
    ..We describe a case of chronic pulmonary infection in an immunocompetent patient. Our observation confirms clinical, diagnostic, and treatment difficulties in the management of M. lentiflavum infection...
  2. pmc Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletii
    Adrian M Zelazny
    Microbiology Service, Department of Laboratory Medicine, NIAD, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Microbiol 47:1985-95. 2009
    ..abscessus and closely related species. Molecular typing complements sequence-based identification and provides information on prevalent clones with possible relevant clinical aspects...
  3. ncbi An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
    David E Griffith
    Am J Respir Crit Care Med 175:367-416. 2007
  4. doi Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiology
    P Maureen Cassidy
    Department of Human Services, Oregon Public Health Division, Portland, USA
    Clin Infect Dis 49:e124-9. 2009
    ..We sought to estimate NTM disease prevalence in Oregon, and describe disease by site, species, and patient demographic characteristics...
  5. pmc Molecular characterization of Mycobacterium massiliense and Mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic procedures
    Cristina Viana-Niero
    Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Departamento de Microbiologia, Imunologia e Parasitologia, Rua Botucatu, 862, São Paulo 04023 062, Brazil
    J Clin Microbiol 46:850-5. 2008
    ..abscessus...
  6. ncbi PCR restriction fragment length polymorphism analysis (PRA)-algorithm targeting 644 bp Heat Shock Protein 65 (hsp65) gene for differentiation of Mycobacterium spp
    Hong Kim
    Department of Microbiology and Liver Research Institute, College of Medicine, Seoul National University, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    J Microbiol Methods 62:199-209. 2005
    ..Our results suggest that this novel PRA offers a simple, rapid, and accurate method for the identification of mycobacteria culture isolates at the species level...
  7. doi Innate response of human endothelial cells infected with mycobacteria
    Blanca Estela García-Pérez
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Prolongacion de Carpio y Plan de Ayala S N, Z P 11340, Mexico, D F, Mexico
    Immunobiology 216:925-35. 2011
    ..As a whole, our results describe some aspects of the innate response of HUVEC infected by mycobacteria with different virulence and suggest that a strong cytoskeleton mobilization triggers a high NO production in these cells...
  8. pmc Multicenter cross-sectional study of nontuberculous mycobacterial infections among cystic fibrosis patients, Israel
    Isaac Levy
    Sheba Medical Center, Tel Hashomer, Israel
    Emerg Infect Dis 14:378-84. 2008
    ..17-1.85, respectively). The incidence of NTM pulmonary infections is increasing among cystic fibrosis patients, reflecting the increase in longevity of such patients as well as environmental exposure to various species of mycobacteria...
  9. pmc Amoebal coculture of "Mycobacterium massiliense" sp. nov. from the sputum of a patient with hemoptoic pneumonia
    Toidi Adekambi
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, Université de la Méditteranée, Marseille, France
    J Clin Microbiol 42:5493-501. 2004
    ..The type strain has been deposited in the Collection Institut Pasteur as CIP 108297(T) and in Culture Collection of the University of Goteborg, Goteborg, Sweden, as CCUG 48898(T)...
  10. pmc Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003
    Theodore K Marras
    Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Canada
    Thorax 62:661-6. 2007
    ..A study was undertaken of the "isolation prevalence" of pulmonary NTM in Ontario, Canada between 1997 and 2003 and the frequency of pulmonary NTM "disease"...
  11. ncbi Relationship between mycobacteria and amoebae: ecological and epidemiological concerns
    V Thomas
    STERIS Laboratory, CEA DSV IMETI SEPIA, 18 route du Panorama, 92260 Fontenay aux Roses, France
    Lett Appl Microbiol 45:349-57. 2007
    ..This review will consider the progress made in understanding the relationships between mycobacteria and amoebae, and their consequences in terms of ecology and epidemiology...
  12. pmc Insights into early mycobacterial pathogenesis from the zebrafish
    Robin Lesley
    Department of Microbiology, Box 357242, 1959 NE Pacific Street, University of Washington, Seattle, WA 98195, United States
    Curr Opin Microbiol 11:277-83. 2008
    ..As these studies uncover new facets of the bacteria-host interactions in tuberculosis they raise even more questions for future investigation...
  13. ncbi Recovery rate of NTM from AFB smear-positive sputum specimens at a medical centre in South Korea
    K Jeon
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Int J Tuberc Lung Dis 9:1046-51. 2005
    ..To investigate the recovery rate of non-tuberculous mycobacteria (NTM) from acid-fast bacilli (AFB) smear-positive sputum specimens at a tertiary care medical centre in South Korea with a high pulmonary tuberculosis (PTB) burden...
  14. ncbi Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice
    H Yamada
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo
    Lab Invest 80:759-67. 2000
    ..Our data clearly indicate that IL-1 is important for the generation of early-phase protective immunity against mycobacterial infection...
  15. ncbi Infections due to rapidly growing mycobacteria
    Mary A De Groote
    University of Colorado, Boulder, Colorado, USA
    Clin Infect Dis 42:1756-63. 2006
    ..Here, we focus on the members of the rapidly growing mycobacteria because of their emerging importance in both sporadic infections and outbreak settings...
  16. pmc Burden of unidentifiable mycobacteria in a reference laboratory
    E Tortoli
    Regional Mycobacteria Reference Center, Microbiology and Virology Laboratory, Careggi Hospital, University of Florence, Florence, Italy
    J Clin Microbiol 39:4058-65. 2001
    ..Our report also shows the usefulness of the integration of novel technology to routine diagnosis, especially in cases involving slow-growing microorganisms such as mycobacteria...
  17. pmc Inaccuracy of single-target sequencing for discriminating species of the Mycobacterium abscessus group
    Edouard Macheras
    Hopital Ambroise Pare, Boulogne Billancourt, France
    J Clin Microbiol 47:2596-600. 2009
    ..Sequence analysis of five housekeeping genes also showed composite patterns in 8 of these 15 isolates...
  18. doi Mycobacterium abscessus Glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage TNF-alpha by preventing interaction with TLR2
    Elizabeth R Rhoades
    Cornell Nanoscale Science and Technology Facility, Cornell University, Ithaca, NY 14853, USA
    J Immunol 183:1997-2007. 2009
    ..abscessus cell wall masks underlying cell wall lipids involved in stimulating the innate immune response, thereby facilitating colonization. Conversely spontaneous "unmasking" of cell wall lipids may promote airway inflammation...
  19. doi Prevalence and associated risk factors of mycobacterial infections in slaughter pigs from Mubende district in Uganda
    Adrian Muwonge
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P O Box 8146 Dep, 0033, Oslo, Norway
    Trop Anim Health Prod 42:905-13. 2010
    ..This then warrants further molecular investigation to identify the specific Mycobacterium species and their public health importance in this area...
  20. doi Outbreak of Mycobacterium abscessus wound infections among "lipotourists" from the United States who underwent abdominoplasty in the Dominican Republic
    E Yoko Furuya
    Department of Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, New York, USA
    Clin Infect Dis 46:1181-8. 2008
    ..Some US residents travel abroad to undergo cosmetic surgery for fat removal, a practice referred to as "lipotourism." Mycobacterium abscessus can cause postsurgical wound infection...
  21. doi Adult-onset immunodeficiency in Thailand and Taiwan
    Sarah K Browne
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 367:725-34. 2012
    ..Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence are unknown...
  22. doi Diagnosis and treatment of lung infection with nontuberculous mycobacteria
    Sandra M Arend
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Pulm Med 15:201-8. 2009
    ..This review summarizes recent literature regarding epidemiological, clinical, diagnostic and therapeutic aspects of NTM lung infections...
  23. doi Clinical relevance of non-tuberculous mycobacteria isolated in the Nijmegen-Arnhem region, The Netherlands
    J van Ingen
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Thorax 64:502-6. 2009
    ..The frequency of clinical isolation of non-tuberculous mycobacteria (NTM) in the Netherlands is increasing, but its clinical relevance is often uncertain...
  24. doi Isolation and identification of nontuberculous mycobacteria from water and soil in central India
    R Narang
    Department of Microbiology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Distt Wardha MS, India
    Indian J Med Microbiol 27:247-50. 2009
    ..Mycobacterium avium was the only species isolated from both clinical and environmental samples of the same patient; but the isolates did not match using PCR for IS 1311 and IS 1245 spacer sequences...
  25. pmc Survival of environmental mycobacteria in Acanthamoeba polyphaga
    Toidi Adekambi
    Unite des Rickettsies, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Appl Environ Microbiol 72:5974-81. 2006
    ..Further studies are required to examine the effects of various germicidal agents on the survival of WBM in an aquatic environment...
  26. pmc Necessity of quality-controlled 16S rRNA gene sequence databases: identifying nontuberculous Mycobacterium species
    C Y Turenne
    National Reference Centre for Mycobacteriology, National Microbiology Laboratory, Population and Public Health Branch, Canada
    J Clin Microbiol 39:3637-48. 2001
    ....
  27. ncbi Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation
    S Dupuis
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM UMR550, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
    Science 293:300-3. 2001
    ..It impairs the nuclear accumulation of GAF but not of ISGF3 in heterozygous cells stimulated by IFNs. Thus, the antimycobacterial, but not the antiviral, effects of human IFNs are principally mediated by GAF...
  28. doi Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease
    Edward D Chan
    Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 43:387-93. 2010
    ..However, much remains to be discovered on why seemingly healthy individuals, particularly slender postmenopausal women with thoracic cage anomalies, appear to be at increased risk...
  29. doi Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease
    Kevin L Winthrop
    Oregon Health and Science University, Portland, OR 97239, USA
    Am J Respir Crit Care Med 182:977-82. 2010
    ..Respiratory specimens with nontuberculous mycobacteria (NTM) are increasingly common; however, pulmonary disease prevalence is unknown...
  30. ncbi Species identification of neglected nontuberculous mycobacteria in a developing country
    Hasan Shojaei
    Isfahan University of Medical Sciences, Isfahan, Iran
    Jpn J Infect Dis 64:265-71. 2011
    ..With regard to the complexity of identification, it is recommended that laboratory diagnosis of NTM diseases be centralized by strengthening or setting up quality national and regional infrastructure...
  31. pmc Efficient differentiation of Mycobacterium abscessus complex isolates to the species level by a novel PCR-based variable-number tandem-repeat assay
    Go Eun Choi
    Department of Laboratory Medicine, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam do 626 770, South Korea
    J Clin Microbiol 49:1107-9. 2011
    ..The assay accuracy was confirmed by a multiple-target sequence analysis. The duplex PCR assay is a one-step, reliable, and accurate assay for discriminating M. abscessus species...
  32. pmc THP-1 cell apoptosis in response to Mycobacterial infection
    Carrie J Riendeau
    Department of Pathology and Laboratory Medicine Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Infect Immun 71:254-9. 2003
    ..Interference with TNF death signaling may be a virulence mechanism that allows M. tuberculosis to circumvent innate defenses leading to apoptosis of infected host cells...
  33. pmc Rapid Identification of Mycobacterium tuberculosis and nontuberculous mycobacteria by multiplex, real-time PCR
    E T Richardson
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Microbiol 47:1497-502. 2009
    ..We conclude that this multiplex, real-time PCR assay is a useful diagnostic tool for the rapid and accurate identification of MTC and clinically relevant nontuberculous mycobacteria...
  34. pmc Direct identification of mycobacteria from MB/BacT alert 3D bottles: comparative evaluation of two commercial probe assays
    C Scarparo
    Regional Mycobacteria Reference Centre, Laboratory of Clinical Microbiology and Virology, San Bortolo Hospital, Vicenza, Italy
    J Clin Microbiol 39:3222-7. 2001
    ....
  35. doi Mycobacterial and other serious infections in patients receiving anti-tumor necrosis factor and other newly approved biologic therapies: case finding through the Emerging Infections Network
    Kevin L Winthrop
    Oregon Health and Sciences University, Portland 97239, USA
    Clin Infect Dis 46:1738-40. 2008
    ..Nontuberculous mycobacterial infections, histoplasmosis, and invasive Staphylococcus aureus infection were all reported more frequently than was tuberculosis disease in this context...
  36. ncbi The new mycobacteria: an update
    Enrico Tortoli
    Regional Reference Centre for Mycobacteria, Careggi Hospital, Florence, Italy
    FEMS Immunol Med Microbiol 48:159-78. 2006
    ..The aim of this present update is to provide epidemiological and clinical information along with major phenotypic and genotypic characteristics of the species described in the last 3 years...
  37. ncbi Genetic dissection of immunity to mycobacteria: the human model
    Jean Laurent Casanova
    Laboratory of Human Genetics of Infectious Diseases, Université René Descartes INSERM U550, Necker Medical School, 156 rue de Vaugirard, 75015 Paris, France
    Annu Rev Immunol 20:581-620. 2002
    ..The human model has potential uses beyond the study of mycobacterial infections and may well become a model of choice for the investigation of immunity to infectious agents...
  38. pmc Differentiation of mycobacterial species by PCR-restriction analysis of DNA (342 base pairs) of the RNA polymerase gene (rpoB)
    B J Kim
    Department of Microbiology, Cheju National University College of Medicine, Cheju 690-7561
    J Clin Microbiol 39:2102-9. 2001
    ..These results suggest that PRA of rpoB DNA is a simple and feasible method not only for the differentiation of culture isolates but also for the rapid detection and identification of pathogenic mycobacteria in primary clinical specimens...
  39. ncbi A role for dendritic cells in the dissemination of mycobacterial infection
    Ian R Humphreys
    Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Microbes Infect 8:1339-46. 2006
    ..The results are consistent with a model in which mycobacterial dissemination from the lung is initiated by the migration of infected dendritic cells to the draining lymph nodes...
  40. pmc Immune gene networks of mycobacterial vaccine-elicited cellular responses and immunity
    Dan Huang
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois at Chicago, IL, 60612, USA
    J Infect Dis 195:55-69. 2007
    ..These findings provide molecular evidence suggesting that the BCG-induced gene networks may represent global transcriptomes and proteomes underlying the development of T cell responses and, ultimately, immunity to mycobacteria...
  41. pmc Factors associated with pastoral community knowledge and occurrence of mycobacterial infections in human-animal interface areas of Nakasongola and Mubende districts, Uganda
    Clovice Kankya
    Department of Veterinary Public Health, Faculty of Veterinary Medicine Makerere University, P, O, Box 7062, Kampala, Uganda
    BMC Public Health 10:471. 2010
    ....
  42. ncbi Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency
    Stephanie Dupuis
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM UMR550, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
    Nat Genet 33:388-91. 2003
    ..Viral multiplication was not inhibited by recombinant IFN-alpha/beta in cell lines from the two individuals. Inherited impairment of the STAT1-dependent response to human IFN-alpha/beta thus results in susceptibility to viral disease...
  43. ncbi Detection of mixed infections with Mycobacterium lentiflavum and Mycobacterium avium by molecular genotyping methods
    Philip Suffys
    Department of Mycobacterioses, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    J Med Microbiol 55:127-31. 2006
    ..At the time of detection, both cases were also infected with M. avium, suggesting an underestimation of infection with M. lentiflavum and co-infection with different Mycobacterium species...
  44. pmc Acute respiratory failure involving an R variant of Mycobacterium abscessus
    Emilie Catherinot
    Laboratoire de Microbiologie, AP HP, Hôpital Raymond Poincaré et Hôpital Ambroise Paré, and Université de Versailles Saint Quentin en Yvelines, EA3647, Garches, France
    J Clin Microbiol 47:271-4. 2009
    ..This report emphasizes the role of R forms in severe M. abscessus infections...
  45. doi BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular method
    So Hee Kim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
    Vaccine 26:4379-81. 2008
    ..The isolates were identified as BCG Tokyo strains by the deletion of the region of difference 1 (RD1) and characterization of RD8 and RD14 using the multiplex polymerase chain reaction...
  46. doi Mycobacterium riyadhense sp. nov., a non-tuberculous species identified as Mycobacterium tuberculosis complex by a commercial line-probe assay
    Jakko van Ingen
    National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Int J Syst Evol Microbiol 59:1049-53. 2009
    ..We propose the name Mycobacterium riyadhense sp. nov. to accommodate this strain. The type strain is NLA000201958(T) (=CIP 109808(T) =DSM 45176(T))...
  47. ncbi Mycobacterial granulomas: keys to a long-lasting host-pathogen relationship
    Dominic O Co
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, 53706, USA
    Clin Immunol 113:130-6. 2004
    ....
  48. doi Anti-interferon-γ autoantibody and opportunistic infections: case series and review of the literature
    T Kampitak
    Division of Allergy and Clinical Immunology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Infection 39:65-71. 2011
    ..Two patients also developed Sweet's syndrome during the course of infections. In addition, we also review all previous reports of patients with anti-IFN-γ antibodies who were susceptible to NTM and Salmonella infections...
  49. ncbi Mycobacterium wolinskyi sp. nov. and Mycobacterium goodii sp. nov., two new rapidly growing species related to Mycobacterium smegmatis and associated with human wound infections: a cooperative study from the International Working Group on Mycobacterial Ta
    B A Brown
    Department of Microbiology, University of Texas Health Center at Tyler 75708 3154, USA
    Int J Syst Bacteriol 49:1493-511. 1999
    ..nov. for group 2 isolates (type strain ATCC 700504T = MO69T), Mycobacterium wolinskyi sp. nov. for group 3 isolates (type strain ATCC 700010T = MO739T) and Mycobacterium smegmatis sensu stricto for group 1 isolates...
  50. ncbi A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion
    Lian Yong Gao
    Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA
    Mol Microbiol 53:1677-93. 2004
    ..marinum homologue of Rv3881c, not previously implicated in virulence, led to a much more attenuated phenotype in macrophages and in vivo, suggesting that this gene plays additional roles in M. marinum survival in the host...
  51. ncbi Mycobacterium abscessus and other nontuberculous mycobacteria: evolving respiratory pathogens in cystic fibrosis: a case report and review
    Don Hayes
    Department of Medicine and Pediatrics, University of Wisconsin Medical School, Clinical Sciences Center, Madison, WI 53792, USA
    South Med J 98:657-61. 2005
    ..As more is discovered about NTM, the pathogenicity and virulence of these organisms should be considered in the setting of CF and treated...
  52. ncbi rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. nov
    Toidi Adekambi
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, 27, Boulevard Jean Moulin, Université de la Méditerranée and Assistance Publique Hôpitaux de Marseille Timone, Fédération de Microbiologie Clinique, Marseille, France
    Int J Syst Evol Microbiol 56:133-43. 2006
    ....
  53. ncbi Human immunodeficiencies that predispose to intracellular bacterial infections
    Rainer Doffinger
    Department of Clinical Biochemistry and Immunology, Cambridge, United Kingdom
    Curr Opin Rheumatol 17:440-6. 2005
    ..This review addresses the effects of inherited and acquired immunodeficiencies on the susceptibility to the development of intracellular bacterial infections...
  54. pmc An oxidative environment promotes growth of Mycobacterium abscessus
    Rebecca E Oberley-Deegan
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Free Radic Biol Med 49:1666-73. 2010
    ..abscessus growth is inhibited. These results lead us to postulate that antioxidants may aid in the treatment of M. abscessus infections...
  55. ncbi [Nontuberculous mycobacterial infection in patients with cystic fibrosis: a multicenter prevalence study]
    Rosa M Girón
    Unidad de fibrosis quistica, Hospital de la Princesa, Madrid, Espana
    Arch Bronconeumol 44:679-84. 2008
    ..To determine the prevalence of nontuberculous mycobacterial infection in patients with cystic fibrosis...
  56. pmc Anti-CD20 (rituximab) therapy for anti-IFN-γ autoantibody-associated nontuberculous mycobacterial infection
    Sarah K Browne
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 119:3933-9. 2012
    ....
  57. doi Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants
    Anne Laure Roux
    EA 3647 Physiopathologie et diagnostic des infections microbiennes, Universite Versailles St Quentin, and Laboratoire de Microbiologie, Hopital Raymond Poincare, AP HP, Garches, France
    Cell Microbiol 13:692-704. 2011
    ..In conclusion, R morphotype in M. abscessus is associated with increased synthesis/exposure at the cell surface of lipoproteins, these changes profoundly modifying the innate immune response through TLR-2-dependent mechanisms...
  58. doi Pulmonary infections associated with non-tuberculous mycobacteria in immunocompetent patients
    Claudio Piersimoni
    Department of Clinical Microbiology, United Hospitals, Ancona, Italy
    Lancet Infect Dis 8:323-34. 2008
    ..We discuss the epidemiological features, clinical syndromes, and developments in the investigation, prevention, and treatment of pulmonary non-tuberculous mycobacterial infections...
  59. pmc Identification of Mycobacterium spp. of veterinary importance using rpoB gene sequencing
    James Higgins
    Mycobacteria and Brucella Section, National Veterinary Services Laboratories, USDA APHIS, 1920 Dayton Ave, Ames, IA 50010, USA
    BMC Vet Res 7:77. 2011
    ..Given that MAC are important pathogens in livestock, companion animals, and zoo/exotic animals, we were interested in evaluating the use of rpoB sequencing for identification of Mycobacterium isolates of veterinary origin...
  60. ncbi Mycobacterial species diversity at a general hospital on the island of Crete: first detection of Mycobacterium lentiflavum in Greece
    Ioannis K Neonakis
    Mycobacteriology Laboratory, Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, 712 01 Heraklion, Crete, Greece
    Scand J Infect Dis 39:875-9. 2007
    ..All strains exhibited multidrug resistance. The patients were adults with immunosuppression or predisposing conditions for NTM infection. Diagnosis of true infection was either not pursued or the patients died shortly after isolation...
  61. ncbi Cervical lymphadenitis caused by Mycobacterium lentiflavum
    Froilán Cabria
    Department of Medical Microbiology, Fundacion Jimenez Diaz, Madrid, Spain
    Pediatr Infect Dis J 21:574-5. 2002
    ..The patient was a 19-month-old boy with involvement of a cervical lymph node. Surgical removal of the lymphadenopathy was both diagnostic and curative...
  62. ncbi Isolation and automated ribotyping of Mycobacterium lentiflavum from drinking water distribution system and clinical specimens
    Irina Tsitko
    Department of Applied Chemistry and Microbiology, National Public Health Institute, Turku, Finland
    FEMS Microbiol Lett 256:236-43. 2006
    ..The drinking water distribution system may, thus, be a source of nontuberculous mycobacteria resistant to multiple drugs...
  63. pmc Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia
    Donald C Vinh
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 115:1519-29. 2010
    ..This novel clinical syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern...
  64. ncbi Enterobacterial repetitive intergenic consensus PCR is a useful tool for typing Mycobacterium chelonae and Mycobacterium abscessus isolates
    Jorge Luiz Mello Sampaio
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862 3 andar 04023 062, Sao Paulo, Brazil
    Diagn Microbiol Infect Dis 55:107-18. 2006
    ..chelonae-abscessus group...
  65. ncbi Cutaneous infection by Mycobacterium lentiflavum in a patient with HIV
    Miguel Montejo
    Dermatology 213:173-4. 2006
  66. pmc Disseminated Mycobacterium lentiflavum infection in a human immunodeficiency virus-infected patient
    S N Niobe
    , , , 33076 Bordeaux Cedex, France
    J Clin Microbiol 39:2030-2. 2001
    ..Furthermore, we describe here the analysis of the 16S-23S rRNA internal transcribed spacer sequence of M. lentiflavum...
  67. pmc Changing epidemiology of pulmonary nontuberculous mycobacteria infections
    Rachel M Thomson
    Queensland Tuberculosis Control Centre, Brisbane, Queensland, Australia
    Emerg Infect Dis 16:1576-83. 2010
    ..Mycobacterium intracellulare is the main pathogen associated with the increase in isolates speciated in Queensland...
  68. pmc Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant
    Hannah E Volkman
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA
    PLoS Biol 2:e367. 2004
    ..This Mycobacterium-induced macrophage aggregation in turn is tightly linked to intercellular bacterial dissemination and increased bacterial numbers. Thus, mycobacteria co-opt host granulomas for their virulence...
  69. ncbi [Mycobacterium lentiflavum infection: case history and review of the medical literature]
    Maria Jose Uria
    Enferm Infecc Microbiol Clin 21:274-5. 2003
  70. pmc Characterization of mycobacterial isolates phylogenetically related to, but different from Mycobacterium simiae
    E Tortoli
    Laboratory of Microbiology and Virology, Careggi Hospital, Firenze, Italy
    J Clin Microbiol 35:697-702. 1997
    ..Sophisticated techniques, like genetic sequencing or HPLC, by now seem indispensable for differentiating unusual and new mycobacteria from well-established ones...
  71. ncbi Mycobacterium lentiflavum, an emerging pathogen?
    Enrico Tortoli
    Microbiology and Virology Laboratory, Regional Reference Center for Mycobacteria, Careggi Hospital, 50134 Florence, Italy
    J Infect 52:e185-7. 2006
    ....
  72. ncbi The secret lives of the pathogenic mycobacteria
    Christine L Cosma
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Microbiol 57:641-76. 2003
    ..In addition, we highlight current controversies and unanswered questions in these areas...
  73. ncbi Immune restoration disease after antiretroviral therapy
    Martyn A French
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital and School of Surgery and Pathology, University of Western Australia, Perth, Australia
    AIDS 18:1615-27. 2004
    ..Investigation of strategies to prevent IRD is a priority, particularly in developing countries, and requires the development of risk assessment methods and diagnostic criteria...
  74. pmc Mycobacteria causing human cervical lymphadenitis in pastoral communities in the Karamoja region of Uganda
    J Oloya
    Department of Veterinary Public Health and Preventive Medicine, Makerere University, Kampala, Uganda
    Epidemiol Infect 136:636-43. 2008
    ..Isolation of environmental mycobacteria also confirms their increasing role in human disease and the occupational risk of infection in the transhumant ecosystem in the absence of safe drinking water and environmental contamination...
  75. pmc Increasing reports of non-tuberculous mycobacteria in England, Wales and Northern Ireland, 1995-2006
    Jonathan E Moore
    Health Protection Agency Centre for Infections, Respiratory Diseases Department Tuberculosis Section, 61 Colindale Avenue, London NW9 5EQ, UK
    BMC Public Health 10:612. 2010
    ..We investigated recent trends in, and the epidemiology of, non-tuberculous mycobacterial infections in England, Wales and Northern Ireland, 1995-2006...
  76. ncbi Nontuberculous mycobacterial immune reconstitution syndrome in HIV-infected patients: spectrum of disease and long-term follow-up
    Peter Phillips
    Division of Infectious Diseases, St Paul s Hospital, Vancouver, British Columbia, Canada
    Clin Infect Dis 41:1483-97. 2005
    ..The long-term outcome and spectrum of disease of nontuberculous mycobacterial immune reconstitution syndrome have not been described...
  77. doi Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1
    Dong Min Shin
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Cell Microbiol 10:1608-21. 2008
    ..Collectively, these data demonstrate that Mab actively internalizes into and robustly activates innate immune responses in macrophages through a physical and functional interaction between TLR2 and dectin-1...
  78. doi Spectrum of CNS disease caused by rapidly growing mycobacteria
    Naasha J Talati
    Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA
    Lancet Infect Dis 8:390-8. 2008
    ..Treatment requires a long course of two or more antibiotics that have the ability to penetrate the blood-brain barrier, and possibly of steroids as immunomodulatory agents, such as those used in tuberculous meningitis...
  79. ncbi TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection
    Daniel R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Sydney, New South Wales, Australia
    J Immunol 168:4620-7. 2002
    ..Therefore, TNF orchestrates early induction of chemokines and initial leukocyte recruitment, but has an additional role in the aggregation of leukocytes into functional granulomas capable of controlling virulent mycobacterial infection...
  80. pmc Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice
    I Sugawara
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo 204 0022, Japan
    Infect Immun 67:2585-9. 1999
    ..Therefore, IL-18 is important for the generation of protective immunity to mycobacteria, and its main function is the induction of IFN-gamma expression...
  81. pmc Human infections due to Mycobacterium lentiflavum
    Enrico Tortoli
    Regional Reference Center for Mycobacteria, Microbiology and Virology Laboratory, Careggi Hospital, Italy
    J Clin Microbiol 40:728-9. 2002
    ..In the first, the mycobacterium was responsible for chronic pulmonary disease in an elderly woman; in the second, it gave rise to cervical lymphadenitis in a child; and in the third, it caused a liver abscess in a young AIDS patient...
  82. pmc Identification of an emerging pathogen, Mycobacterium massiliense, by rpoB sequencing of clinical isolates collected in the United States
    Keith E Simmon
    Associated Regional and University Pathologists ARUP Instititue for Clincal and Experimental Pathology, Salt Lake City, UT 84108, USA
    J Clin Microbiol 45:1978-80. 2007
    ..chelonae/M. abscessus and identified M. massiliense from isolates from two patients with invasive disease representing the first reported cases in the United States...
  83. doi Environmental sources of rapid growing nontuberculous mycobacteria causing disease in humans
    J van Ingen
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Microbiol Infect 15:888-93. 2009
    ..Furthermore, studies should focus on the actual sites of the active replication of RGM; their presence may not indicate their natural habitat...
  84. ncbi Mycobacterium sherrisii: a new opportunistic agent in HIV infection?
    Pierre Loulergue
    AIDS 21:893-4. 2007
  85. ncbi Interferon-gamma release assays improve the diagnosis of tuberculosis and nontuberculous mycobacterial disease in children in a country with a low incidence of tuberculosis
    A K Detjen
    Department of Pediatric Pneumology and Immunology, Charite University Medical Center, Berlin, Germany
    Clin Infect Dis 45:322-8. 2007
    ..We assessed the diagnostic accuracy of IGRAs for TB in children in an area with a low incidence of TB...
  86. pmc Characterization of an unusual Mycobacterium: a possible missing link between Mycobacterium marinum and Mycobacterium ulcerans
    K Chemlal
    Department of Microbiology, Mycobacteriology Unit, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
    J Clin Microbiol 40:2370-80. 2002
    ..Jenkin, P. D. Johnson, and J. K. Davies, J. Bacteriol. 182:6322-6330, 2000) that M. ulcerans represents a relatively recent phylogenetic derivative of M. marinum resulting from the systematic acquisition of foreign DNA fragments...
  87. ncbi Emergence of Mycobacterium simiae in respiratory specimens
    Zmira Samra
    Departmnent of Clinical Microbiology, Rabin Medical Centre, Beilinson Campus, Sackler Faculty of Medicine, Israel
    Scand J Infect Dis 37:838-41. 2005
    ..9% to 7.5%; and Mycobacterium haemophilum 1.2% to 0%). These findings disclose major temporal changes in the distribution of mycobacterial species in respiratory specimens with an impressive emergence and takeover of M. simiae...
  88. pmc Mycobacterium haemophilum and lymphadenitis in children
    Lesla E S Bruijnesteijn van Coppenraet
    Leiden University Medical Center, Leiden, The Netherlands
    Emerg Infect Dis 11:62-8. 2005
    ..haemophilum was the second most commonly recognized pathogen. Real-time PCR results were superior to culture because only 9 (56%) of the 16 diagnosed M. haemophilum infections were positive by culture...
  89. pmc Controlled comparison of BACTEC 13A, MYCO/F LYTIC, BacT/ALERT MB, and ISOLATOR 10 systems for detection of mycobacteremia
    John A Crump
    Clinical Microbiology Laboratory, Duke University Medical Center and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Clin Microbiol 41:1987-90. 2003
    ....
  90. pmc Identification of Mycobacterium spp. by using a commercial 16S ribosomal DNA sequencing kit and additional sequencing libraries
    J L Cloud
    Associated Regional and University Pathologists ARUP, Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    J Clin Microbiol 40:400-6. 2002
    ....
  91. ncbi Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected mice
    R Reljic
    Department for Oral Medicine and Pathology, Guy s Campus of King s College, London, UK
    Tuberculosis (Edinb) 85:81-8. 2005
    ..In this paper we investigated if their early infection in the lungs represents a plausible alternative to cross-priming with mycobacterial antigens acquired from infected macrophages...
  92. ncbi Mycobacterium simae outbreak associated with a hospital water supply
    Nicholas G Conger
    Department of Infectious Disease, Wilford Hall Medical Center, Lackland AFB, Texas, USA
    Infect Control Hosp Epidemiol 25:1050-5. 2004
    ..Our institution saw an increase in M. simiae isolates in 2001. An investigation into possible contaminated water sources was undertaken...
  93. ncbi Mycobacteriosis in patients with fever of unknown origin
    Chuen Chin
    Section of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC
    J Microbiol Immunol Infect 36:248-53. 2003
    ..In conclusion, mycobacteriosis remains the leading cause of FUO in southern Taiwan and it is important to screen for this treatable disease in all cases of FUO...
  94. pmc Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humans
    M A Saubolle
    Department of Pathology, Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA
    Clin Microbiol Rev 9:435-47. 1996
    ..The organisms are most susceptible to ciprofloxacin, clarithromycin, rifabutin, and rifampin. Timely diagnosis and therapy require communication between clinician and the laboratory...
  95. pmc Application of the Sherlock Mycobacteria Identification System using high-performance liquid chromatography in a clinical laboratory
    J A Kellogg
    Clinical Microbiology Laboratory, York Hospital, York, PA 17405, USA
    J Clin Microbiol 39:964-70. 2001
    ..The SMIS, combined with knowledge of RPHRs, RRTs, and phenotypic characteristics, offers a rapid, reasonably accurate, cost-effective alternative to more traditional methods of mycobacterial species identification...
  96. pmc Novel diagnostic algorithm for identification of mycobacteria using genus-specific amplification of the 16S-23S rRNA gene spacer and restriction endonucleases
    A Roth
    Institut für Mikrobiologie und Immunologie, Lungenklinik Heckeshorn, 14109 Berlin, Germany
    J Clin Microbiol 38:1094-104. 2000
    ....
  97. ncbi Cutaneous Mycobacterium haemophilum infections in immunocompromised patients in a dermatology clinic in Singapore
    H H Tan
    National Skin Centre, 1 Mandalay Road, Singapore 308205
    Ann Acad Med Singapore 33:532-6. 2004
    ..Mycobacterium haemophilum, a nontuberculous mycobacterium (NTM) that was first described in 1978, is a pathogen that can cause an array of symptoms in immunocompromised patients, predominantly cutaneous...
  98. ncbi Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way
    Jeffrey S Schorey
    University of Notre Dame, Department of Biology and Center of Tropical Disease Research and Training, 130 Galvin Life Science Center, Notre Dame, IN 46556, USA
    Cell Microbiol 5:133-42. 2003
    ..Therefore, the ability of pathogenic mycobacteria to limit MAPK activity is likely an important virulence mechanism and may be a potential therapeutic target...
  99. ncbi Two decades of disseminated tuberculosis at a university medical center: the expanding role of mycobacterial blood culture
    John A Crump
    Clinical Microbiology Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 37:1037-43. 2003
    ..Mycobacterial blood culture can play an increasing role in the diagnosis of disseminated tuberculosis when localized disease is not found...
  100. ncbi Non-tuberculous mycobacteria I: one year clinical isolates identification in Tertiary Hospital Aids Reference Center, Rio de Janeiro, Brazil, in pre highly active antiretroviral therapy era
    Rosa Maria Carvalho Ferreira
    Laboratorio de Micobacterias, Hospital Evandro Chagas
    Mem Inst Oswaldo Cruz 97:725-9. 2002
    ..Some discrepancies were seen between the identification methods and further investigations must be done to better characterize NTM isolates using other phenotypic and genotypic methods...
  101. pmc Fatal pulmonary infection with Mycobacterium celatum in an apparently immunocompetent patient
    I Bux-Gewehr
    I Medizinische Klinik, DRK Krankenhaus Neuwied, Germany
    J Clin Microbiol 36:587-8. 1998
    ..We present here, to our knowledge, the first report of a fatal pulmonary infection caused by M. celatum in a 73-year-old immunocompetent female patient. The mycobacterium was identified by a 16S rRNA sequence analysis...

Research Grants83

  1. Alveolar macrophage and mycobacteria
    Rajamouli Pasula; Fiscal Year: 2007
    ..abstract_text> ..
  2. Cell Biology of Mycobacterium tuberculosis Infection
    David G Russell; Fiscal Year: 2010
    ..tuberculosis. We propose determining how the bacterium's metabolism is realigned to access these carbon sources. ..
  3. Mentoring in Tuberculosis Patient-Oriented Research
    Neil Schluger; Fiscal Year: 2007
    ..abstract_text> ..
  4. Training in Translational Lung Research
    Neil Schluger; Fiscal Year: 2007
    ..abstract_text> ..
  5. STRUCTURE OF LAM IN RELATION TO BIOLOGY AND BIOSYNTHESIS
    Delphi Chatterjee; Fiscal Year: 2007
    ..smegmatis and M. tuberculosis all in relation to biology and biosynthesis. ..
  6. Environmental cues and responses in tuberculosis
    David Russell; Fiscal Year: 2007
    ....
  7. Host defense functions of M. tuberculosis lipoglycan
    Edward Chan; Fiscal Year: 2005
    ..3. To elucidate the role of the TLRs, MAPK and NFkB signaling pathways, and ManLAM in controlling the growth of M. tuberculosis in mouse and human macrophages and to correlate effects on growth with NO* and TNFa expression. ..
  8. Zeiss LSM510 Meta Confocal Microscope
    David Russell; Fiscal Year: 2007
    ..These data will extend ongoing, NIH-funded programs for identification of new drug targets, vaccines and adjuvants. ..
  9. Investigation of the role of bacteria in the sarcoidosis trimolecular complex
    Wonder Drake; Fiscal Year: 2007
    ....
  10. Role of mycobacteria in sarcoidosis immunopathogenesis
    Wonder Drake; Fiscal Year: 2009
    ..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..
  11. T cell memory to TB in the lung
    Andrea M Cooper; Fiscal Year: 2010
    ..These new cell types may improve the protective effect of vaccines and thereby reduce the incidence of tuberculosis in the world. This will have a significant impact in worldwide public health. ..
  12. Enviromental cues and responses in tuberculosis
    David G Russell; Fiscal Year: 2010
    ..abstract_text> ..
  13. Development of a Novel Strategy of Adjuvant Discovery
    David Russell; Fiscal Year: 2009
    ..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
  14. Impact of chronic infection in the aged on the response to vaccination
    Andrea Cooper; Fiscal Year: 2007
    ..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. ..
  15. Immunotherapeutics and vaccines against anthrax, plague and tularemia
    Zheng Chen; Fiscal Year: 2007
    ....
  16. Role of SOCS proteins in host-pathogen responses
    Peter Murray; Fiscal Year: 2003
    ..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
  17. GENES ASSOCIATED WITH M AVIUM PATHOGENESIS
    Luiz Bermudez; Fiscal Year: 2002
    ..The applicants believe that the studies outlined in this proposal will provide excellent tools for the identification of novel genes associated with mechanisms of pathogenesis of M. avium.m. ..
  18. IMMUNOPATHOGENESIS OF MYCOBACTERIUM AVIUM DISEASE
    Andrea Cooper; Fiscal Year: 2001
    ..Finally, they will test the hypothesis that appropriate chemotherapy can restore the correct immunologic functions/signals, using both established regimens, as well as new compounds recently identified in their laboratory as active. ..
  19. TB LAM AND AG--STRUCTURES CORRELATED WITH BIOLOGY
    Delphi Chatterjee; Fiscal Year: 2001
    ..tuberculosis. The structural studies will directly aid the immunological studies by providing a wealth of LAM related molecules needed to decipher the structural characteristics necessary for recognition by T-cells and macrophages. ..
  20. GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPP
    David Russell; Fiscal Year: 2004
    ..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
  21. Secondary infections during mycobacterial disease
    Matyas Sandor; Fiscal Year: 2004
    ..The goal of this research is to understand the interaction of T cell responses controlling different infections. Hopefully, this will lead to better treatments of mycobacterial disease. ..
  22. The Link Between Anemia of Inflammation and Host Defense
    Seth Rivera; Fiscal Year: 2007
    ..The research has broad relevance to the management of Al during severe infections. ..
  23. T CELLS IN GRANULOMATOUS IMMUNE RESPONSES
    Matyas Sandor; Fiscal Year: 2010
    ..New knowledge of how T cells regulate granulomas will lead to more efficient therapeutic manipulations of granulomatous diseases. ..
  24. T CELLS IN GRANULOMATOUS IMMUNE RESPONSES
    Matyas Sandor; Fiscal Year: 2010
    ..New knowledge of how T cells regulate granulomas will lead to more efficient therapeutic manipulations of granulomatous diseases. ..
  25. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2005
    ..tuberculosis through an exposed population. ..
  26. T CELLS IN GRANULOMATOUS IMMUNE RESPONSES
    Matyas Sandor; Fiscal Year: 2004
    ..abstract_text> ..
  27. BD LSR II Blue Laser Flow cytometer
    Matyas Sandor; Fiscal Year: 2006
    ..A new generation of flow cytometric assays is becoming available and our group of users would like to advance to the next level. ..
  28. Mycobacterial antigen compartmentalization & immunity
    Matyas Sandor; Fiscal Year: 2005
    ..abstract_text> ..
  29. The Basis of Anthrax-Induced Vascular Damage
    James Kirby; Fiscal Year: 2006
    ..As part of this exploration, we hope to identify and test new therapeutic strategies. ..
  30. Role of non-tuberculous mycobacteria in lung disease
    Jason Stout; Fiscal Year: 2006
    ..Our findings will also assist clinicians in predicting which patients with NTM isolated from the respiratory tract will have NTM pulmonary disease. ..