Genomes and Genes
Summary: Infections with bacteria of the genus MYCOBACTERIUM.
Publications186 found, 100 shown here
- Mycobacterium lentiflavum infection in immunocompetent patientChiara Molteni
Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
Emerg Infect Dis 11:119-22. 2005..We describe a case of chronic pulmonary infection in an immunocompetent patient. Our observation confirms clinical, diagnostic, and treatment difficulties in the management of M. lentiflavum infection...
- Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletiiAdrian M Zelazny
Microbiology Service, Department of Laboratory Medicine, NIAD, National Institutes of Health, Bethesda, MD 20892, USA
J Clin Microbiol 47:1985-95. 2009..abscessus and closely related species. Molecular typing complements sequence-based identification and provides information on prevalent clones with possible relevant clinical aspects...
- Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout miceH Yamada
Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo
Lab Invest 80:759-67. 2000..Our data clearly indicate that IL-1 is important for the generation of early-phase protective immunity against mycobacterial infection...
- Rapid Identification of Mycobacterium tuberculosis and nontuberculous mycobacteria by multiplex, real-time PCRE T Richardson
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
J Clin Microbiol 47:1497-502. 2009..We conclude that this multiplex, real-time PCR assay is a useful diagnostic tool for the rapid and accurate identification of MTC and clinically relevant nontuberculous mycobacteria...
- THP-1 cell apoptosis in response to Mycobacterial infectionCarrie J Riendeau
Department of Pathology and Laboratory Medicine. Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Infect Immun 71:254-9. 2003..Interference with TNF death signaling may be a virulence mechanism that allows M. tuberculosis to circumvent innate defenses leading to apoptosis of infected host cells...
- Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiologyP Maureen Cassidy
Department of Human Services, Oregon Public Health Division, Portland, USA
Clin Infect Dis 49:e124-9. 2009..We sought to estimate NTM disease prevalence in Oregon, and describe disease by site, species, and patient demographic characteristics...
- Differentiation of mycobacterial species by PCR-restriction analysis of DNA (342 base pairs) of the RNA polymerase gene (rpoB)B J Kim
Department of Microbiology, Cheju National University College of Medicine, Cheju 690-7561
J Clin Microbiol 39:2102-9. 2001..These results suggest that PRA of rpoB DNA is a simple and feasible method not only for the differentiation of culture isolates but also for the rapid detection and identification of pathogenic mycobacteria in primary clinical specimens...
- A role for dendritic cells in the dissemination of mycobacterial infectionIan R Humphreys
Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Microbes Infect 8:1339-46. 2006..The results are consistent with a model in which mycobacterial dissemination from the lung is initiated by the migration of infected dendritic cells to the draining lymph nodes...
- Amoebal coculture of "Mycobacterium massiliense" sp. nov. from the sputum of a patient with hemoptoic pneumoniaToidi Adekambi
Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, Université de la Méditteranée, Marseille, France
J Clin Microbiol 42:5493-501. 2004..The type strain has been deposited in the Collection Institut Pasteur as CIP 108297(T) and in Culture Collection of the University of Goteborg, Goteborg, Sweden, as CCUG 48898(T)...
- Mycobacterial granulomas: keys to a long-lasting host-pathogen relationshipDominic O Co
Program in Cellular and Molecular Biology, University of Wisconsin-Madison, 53706, USA
Clin Immunol 113:130-6. 2004....
- Cervical lymphadenitis caused by Mycobacterium lentiflavumFroilán Cabria
Department of Medical Microbiology, Fundacion Jimenez Diaz, Madrid, Spain
Pediatr Infect Dis J 21:574-5. 2002..The patient was a 19-month-old boy with involvement of a cervical lymph node. Surgical removal of the lymphadenopathy was both diagnostic and curative...
- Changing epidemiology of pulmonary nontuberculous mycobacteria infectionsRachel M Thomson
Queensland Tuberculosis Control Centre, Brisbane, Queensland, Australia
Emerg Infect Dis 16:1576-83. 2010..Mycobacterium intracellulare is the main pathogen associated with the increase in isolates speciated in Queensland...
- Mycobacterial species diversity at a general hospital on the island of Crete: first detection of Mycobacterium lentiflavum in GreeceIoannis K Neonakis
Mycobacteriology Laboratory, Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, 712 01 Heraklion, Crete, Greece
Scand J Infect Dis 39:875-9. 2007..All strains exhibited multidrug resistance. The patients were adults with immunosuppression or predisposing conditions for NTM infection. Diagnosis of true infection was either not pursued or the patients died shortly after isolation...
- Detection of mixed infections with Mycobacterium lentiflavum and Mycobacterium avium by molecular genotyping methodsPhilip Suffys
Department of Mycobacterioses, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
J Med Microbiol 55:127-31. 2006..At the time of detection, both cases were also infected with M. avium, suggesting an underestimation of infection with M. lentiflavum and co-infection with different Mycobacterium species...
- Isolation and automated ribotyping of Mycobacterium lentiflavum from drinking water distribution system and clinical specimensIrina Tsitko
Department of Applied Chemistry and Microbiology, National Public Health Institute, Turku, Finland
FEMS Microbiol Lett 256:236-43. 2006..The drinking water distribution system may, thus, be a source of nontuberculous mycobacteria resistant to multiple drugs...
- Enterobacterial repetitive intergenic consensus PCR is a useful tool for typing Mycobacterium chelonae and Mycobacterium abscessus isolatesJorge Luiz Mello Sampaio
Departamento de Microbiologia, Imunologia e Parasitologia, , Rua Botucatu, 862-3 andar-04023-062, , Brazil
Diagn Microbiol Infect Dis 55:107-18. 2006..chelonae-abscessus group...
- [Mycobacterium lentiflavum infection: case history and review of the medical literature]Maria Jose Uria
Enferm Infecc Microbiol Clin 21:274-5. 2003
- Mycobacterium lentiflavum, an emerging pathogen?Enrico Tortoli
Microbiology and Virology Laboratory, Regional Reference Center for Mycobacteria, Careggi Hospital, 50134 Florence, Italy
J Infect 52:e185-7. 2006....
- An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseasesDavid E Griffith
Am J Respir Crit Care Med 175:367-416. 2007
- Cutaneous infection by Mycobacterium lentiflavum in a patient with HIVMiguel Montejo
Dermatology 213:173-4. 2006
- Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinantHannah E Volkman
Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA
PLoS Biol 2:e367. 2004..This Mycobacterium-induced macrophage aggregation in turn is tightly linked to intercellular bacterial dissemination and increased bacterial numbers. Thus, mycobacteria co-opt host granulomas for their virulence...
- Mycobacterial and other serious infections in patients receiving anti-tumor necrosis factor and other newly approved biologic therapies: case finding through the Emerging Infections NetworkKevin L Winthrop
Oregon Health and Sciences University, Portland 97239, USA
Clin Infect Dis 46:1738-40. 2008..Nontuberculous mycobacterial infections, histoplasmosis, and invasive Staphylococcus aureus infection were all reported more frequently than was tuberculosis disease in this context...
- Disseminated Mycobacterium lentiflavum infection in a human immunodeficiency virus-infected patientS N Niobe
, , , 33076 Bordeaux Cedex, France
J Clin Microbiol 39:2030-2. 2001..Furthermore, we describe here the analysis of the 16S-23S rRNA internal transcribed spacer sequence of M. lentiflavum...
- Characterization of mycobacterial isolates phylogenetically related to, but different from Mycobacterium simiaeE Tortoli
Laboratory of Microbiology and Virology, Careggi Hospital, Firenze, Italy
J Clin Microbiol 35:697-702. 1997..Sophisticated techniques, like genetic sequencing or HPLC, by now seem indispensable for differentiating unusual and new mycobacteria from well-established ones...
- Human infections due to Mycobacterium lentiflavumEnrico Tortoli
Regional Reference Center for Mycobacteria, Microbiology and Virology Laboratory, Careggi Hospital, Italy
J Clin Microbiol 40:728-9. 2002..In the first, the mycobacterium was responsible for chronic pulmonary disease in an elderly woman; in the second, it gave rise to cervical lymphadenitis in a child; and in the third, it caused a liver abscess in a young AIDS patient...
- Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health diseaseKevin L Winthrop
Oregon Health and Science University, Portland, OR 97239, USA
Am J Respir Crit Care Med 182:977-82. 2010..Respiratory specimens with nontuberculous mycobacteria (NTM) are increasingly common; however, pulmonary disease prevalence is unknown...
- BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular methodSo Hee Kim
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
Vaccine 26:4379-81. 2008..The isolates were identified as BCG Tokyo strains by the deletion of the region of difference 1 (RD1) and characterization of RD8 and RD14 using the multiplex polymerase chain reaction...
- Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasiaDonald C Vinh
Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 115:1519-29. 2010..This novel clinical syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern...
- Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003Theodore K Marras
Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Canada
Thorax 62:661-6. 2007..A study was undertaken of the "isolation prevalence" of pulmonary NTM in Ontario, Canada between 1997 and 2003 and the frequency of pulmonary NTM "disease"...
- Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutationS Dupuis
Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM UMR550, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
Science 293:300-3. 2001..It impairs the nuclear accumulation of GAF but not of ISGF3 in heterozygous cells stimulated by IFNs. Thus, the antimycobacterial, but not the antiviral, effects of human IFNs are principally mediated by GAF...
- Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted miceI Sugawara
Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo 204 0022, Japan
Infect Immun 67:2585-9. 1999..Therefore, IL-18 is important for the generation of protective immunity to mycobacteria, and its main function is the induction of IFN-gamma expression...
- Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiencyStephanie Dupuis
Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM UMR550, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
Nat Genet 33:388-91. 2003..Viral multiplication was not inhibited by recombinant IFN-alpha/beta in cell lines from the two individuals. Inherited impairment of the STAT1-dependent response to human IFN-alpha/beta thus results in susceptibility to viral disease...
- TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infectionDaniel R Roach
Centenary Institute of Cancer Medicine and Cell Biology, Newton, Sydney, New South Wales, Australia
J Immunol 168:4620-7. 2002..Therefore, TNF orchestrates early induction of chemokines and initial leukocyte recruitment, but has an additional role in the aggregation of leukocytes into functional granulomas capable of controlling virulent mycobacterial infection...
- Piscine mycobacteriosis: a literature review covering the agent and the disease it causes in fish and humansA Decostere
Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 99:159-66. 2004..Especially fish handlers and aquarium hobbyists are infected and the disease is mostly confined to the superficial, cooler body tissues, most often the extremities. Dissemination is apparently rare but has been reported...
- Controlled comparison of BACTEC 13A, MYCO/F LYTIC, BacT/ALERT MB, and ISOLATOR 10 systems for detection of mycobacteremiaJohn A Crump
Clinical Microbiology Laboratory, Duke University Medical Center and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
J Clin Microbiol 41:1987-90. 2003....
- Mycobacteriosis in patients with fever of unknown originChuen Chin
Section of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC
J Microbiol Immunol Infect 36:248-53. 2003..In conclusion, mycobacteriosis remains the leading cause of FUO in southern Taiwan and it is important to screen for this treatable disease in all cases of FUO...
- Mycobacterium simae outbreak associated with a hospital water supplyNicholas G Conger
Department of Infectious Disease, Wilford Hall Medical Center, Lackland AFB, Texas, USA
Infect Control Hosp Epidemiol 25:1050-5. 2004..simiae has been recovered from hospital tap water and its first presentation in municipal water. This study raises issues about the need and feasibility of eliminating or avoiding exposure to M. simiae from tap water...
- Cutaneous Mycobacterium haemophilum infections in immunocompromised patients in a dermatology clinic in SingaporeH H Tan
National Skin Centre, 1 Mandalay Road, Singapore 308205
Ann Acad Med Singapore 33:532-6. 2004..Mycobacterium haemophilum, a nontuberculous mycobacterium (NTM) that was first described in 1978, is a pathogen that can cause an array of symptoms in immunocompromised patients, predominantly cutaneous...
- Immune gene networks of mycobacterial vaccine-elicited cellular responses and immunityDan Huang
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois at Chicago, IL, 60612, USA
J Infect Dis 195:55-69. 2007..These findings provide molecular evidence suggesting that the BCG-induced gene networks may represent global transcriptomes and proteomes underlying the development of T cell responses and, ultimately, immunity to mycobacteria...
- Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected miceR Reljic
Department for Oral Medicine and Pathology, Guy's Campus of King's College, London, UK
Tuberculosis (Edinb) 85:81-8. 2005..This finding is pertinent for the regulation of pulmonary and systemic immune responses and possibly for the dissemination of mycobacterial infection by DCs...
- Emergence of Mycobacterium simiae in respiratory specimensZmira Samra
Departmnent of Clinical Microbiology, Rabin Medical Centre, Beilinson Campus, Sackler Faculty of Medicine, Israel
Scand J Infect Dis 37:838-41. 2005..9% to 7.5%; and Mycobacterium haemophilum 1.2% to 0%). These findings disclose major temporal changes in the distribution of mycobacterial species in respiratory specimens with an impressive emergence and takeover of M. simiae...
- Fatal pulmonary infection with Mycobacterium celatum in an apparently immunocompetent patientI Bux-Gewehr
I Medizinische Klinik, DRK Krankenhaus Neuwied, Germany
J Clin Microbiol 36:587-8. 1998..We present here, to our knowledge, the first report of a fatal pulmonary infection caused by M. celatum in a 73-year-old immunocompetent female patient. The mycobacterium was identified by a 16S rRNA sequence analysis...
- Recovery rate of NTM from AFB smear-positive sputum specimens at a medical centre in South KoreaK Jeon
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Int J Tuberc Lung Dis 9:1046-51. 2005..abscessus. CONCLUSION: These results suggest that a substantial proportion of patients at a tertiary care medical centre in South Korea with AFB smear-positive sputum specimens may have NTM lung disease rather than PTB...
- Novel diagnostic algorithm for identification of mycobacteria using genus-specific amplification of the 16S-23S rRNA gene spacer and restriction endonucleasesA Roth
Institut für Mikrobiologie und Immunologie, Lungenklinik Heckeshorn, 14109 Berlin, Germany
J Clin Microbiol 38:1094-104. 2000....
- Comparison of the COBAS AMPLICOR MTB and BDProbeTec ET assays for detection of Mycobacterium tuberculosis in respiratory specimensW H F Goessens
Erasmus MC, University Medical Center Rotterdam, Dept of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
J Clin Microbiol 43:2563-6. 2005....
- Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretroviralsStephen D Lawn
Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Lancet Infect Dis 5:361-73. 2005..We also discuss the problem of IRD associated with mycobacterial diseases in developing countries where tuberculosis prevalence is high and access to HAART is currently expanding...
- Application of the Sherlock Mycobacteria Identification System using high-performance liquid chromatography in a clinical laboratoryJ A Kellogg
Clinical Microbiology Laboratory, York Hospital, York, PA 17405, USA
J Clin Microbiol 39:964-70. 2001..The SMIS, combined with knowledge of RPHRs, RRTs, and phenotypic characteristics, offers a rapid, reasonably accurate, cost-effective alternative to more traditional methods of mycobacterial species identification...
- Mycobacterium haemophilum and lymphadenitis in childrenLesla E S Bruijnesteijn van Coppenraet
Leiden University Medical Center, Leiden, The Netherlands
Emerg Infect Dis 11:62-8. 2005..haemophilum was the second most commonly recognized pathogen. Real-time PCR results were superior to culture because only 9 (56%) of the 16 diagnosed M. haemophilum infections were positive by culture...
- Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humansM A Saubolle
Department of Pathology, Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA
Clin Microbiol Rev 9:435-47. 1996..The organisms are most susceptible to ciprofloxacin, clarithromycin, rifabutin, and rifampin. Timely diagnosis and therapy require communication between clinician and the laboratory...
- Multicenter evaluation of mycobacteria identification by PCR restriction enzyme analysis in laboratories from Latin America and the CaribbeanSylvia Cardoso Leao
Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862 3 degrees andar, São Paulo 04023 062, Brazil
J Microbiol Methods 61:193-9. 2005..In others, improvement in critical points is still necessary...
- Interferon-gamma release assays improve the diagnosis of tuberculosis and nontuberculous mycobacterial disease in children in a country with a low incidence of tuberculosisA K Detjen
Department of Pediatric Pneumology and Immunology, Charite University Medical Center, Berlin, Germany
Clin Infect Dis 45:322-8. 2007..We assessed the diagnostic accuracy of IGRAs for TB in children in an area with a low incidence of TB...
- Environmental sources of rapid growing nontuberculous mycobacteria causing disease in humansJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Clin Microbiol Infect 15:888-93. 2009..Furthermore, studies should focus on the actual sites of the active replication of RGM; their presence may not indicate their natural habitat...
- Identification of Mycobacterium spp. by using a commercial 16S ribosomal DNA sequencing kit and additional sequencing librariesJ L Cloud
Associated Regional and University Pathologists ARUP, Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
J Clin Microbiol 40:400-6. 2002....
- Non-tuberculous mycobacteria I: one year clinical isolates identification in Tertiary Hospital Aids Reference Center, Rio de Janeiro, Brazil, in pre highly active antiretroviral therapy eraRosa Maria Carvalho Ferreira
, Hospital Evandro Chagas
Mem Inst Oswaldo Cruz 97:725-9. 2002..Some discrepancies were seen between the identification methods and further investigations must be done to better characterize NTM isolates using other phenotypic and genotypic methods...
- Novel allelic variants of Mycobacteria isolated in Brazil as determined by PCR-restriction enzyme analysis of hsp65A da Silva Rocha
Biochemistry and Molecular Biology Departmentand, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
J Clin Microbiol 40:4191-6. 2002..Patterns available on the Internet can be introduced into this database, which will make possible the comparison of genotypes from isolates from different parts of the world...
- Characterization of an unusual Mycobacterium: a possible missing link between Mycobacterium marinum and Mycobacterium ulceransK Chemlal
Department of Microbiology, Mycobacteriology Unit, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
J Clin Microbiol 40:2370-80. 2002..Jenkin, P. D. Johnson, and J. K. Davies, J. Bacteriol. 182:6322-6330, 2000) that M. ulcerans represents a relatively recent phylogenetic derivative of M. marinum resulting from the systematic acquisition of foreign DNA fragments...
- Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1Dong Min Shin
Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
Cell Microbiol 10:1608-21. 2008..Collectively, these data demonstrate that Mab actively internalizes into and robustly activates innate immune responses in macrophages through a physical and functional interaction between TLR2 and dectin-1...
- Skin indurations in response to tuberculin testing in patients with nontuberculous mycobacterial lymphadenitisY Haimi-Cohen
Pediatric Day Care Unit, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
Clin Infect Dis 33:1786-8. 2001..In regions with a low incidence of tuberculosis, lymphadenitis thought to be due to nontuberculous mycobacteria should be managed as such, regardless of Mantoux results, thereby avoiding antituberculosis treatment...
- Mycobacterium sherrisii: a new opportunistic agent in HIV infection?Pierre Loulergue
AIDS 21:893-4. 2007
- Identification of an emerging pathogen, Mycobacterium massiliense, by rpoB sequencing of clinical isolates collected in the United StatesKeith E Simmon
Associated Regional and University Pathologists ARUP Instititue for Clincal and Experimental Pathology, Salt Lake City, UT 84108, USA
J Clin Microbiol 45:1978-80. 2007..chelonae/M. abscessus and identified M. massiliense from isolates from two patients with invasive disease representing the first reported cases in the United States...
- Two decades of disseminated tuberculosis at a university medical center: the expanding role of mycobacterial blood cultureJohn A Crump
Clinical Microbiology Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Infect Dis 37:1037-43. 2003..Mycobacterial blood culture can play an increasing role in the diagnosis of disseminated tuberculosis when localized disease is not found...
- Macrophage signalling upon mycobacterial infection: the MAP kinases lead the wayJeffrey S Schorey
University of Notre Dame, Department of Biology and Center of Tropical Disease Research and Training, 130 Galvin Life Science Center, Notre Dame, IN 46556, USA
Cell Microbiol 5:133-42. 2003..Therefore, the ability of pathogenic mycobacteria to limit MAPK activity is likely an important virulence mechanism and may be a potential therapeutic target...
- Molecular systematics support the revival of Mycobacterium salmoniphilum (ex Ross 1960) sp. nov., nom. rev., a species closely related to Mycobacterium chelonaeChristopher M Whipps
Center for Fish Disease Research, Department of Microbiology, 220 Nash Hall, Oregon State University, Corvallis, OR 97331 3404, USA
Int J Syst Evol Microbiol 57:2525-31. 2007..salmoniphilum' as Mycobacterium salmoniphilum (ex Ross 1960) sp. nov., nom. rev., with the type strain SCT (=ATCC 13578T =DSM 43276T)...
- Identification of mycobacteria by matrix-assisted laser desorption ionization-time-of-flight mass spectrometryMichelle Pignone
Bacteriology Program, American Type Culture Collection, 10801 University Blvd, Manassas, Virginia 20110, USA
J Clin Microbiol 44:1963-70. 2006..The data suggest that whole-cell MALDI-TOF MS has potential as a rapid and reproducible method for the identification and characterization of Mycobacterium species...
- Rapid identification of mycobacteria by Raman spectroscopyP C A M Buijtels
University Medical Centre Utrecht, Department of Medical Microbiology, HP G04 614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
J Clin Microbiol 46:961-5. 2008..Raman spectroscopy provides a novel answer to the need for rapid species identification of cultured mycobacteria in a clinical diagnostic setting...
- Comparison of three methods for rapid identification of mycobacterial clinical isolates to the species levelXueqiong Wu
Tuberculosis Research Laboratory, Tuberculosis Center, The 309th Hospital of PLA, Beijing 100091, China
J Clin Microbiol 45:1898-903. 2007..Therefore, the RDBH assay can be considered a rapid, simple, and reliable method for routine identification of frequently occurring and clinically relevant mycobacteria...
- Molecular characterization of Mycobacterium massiliense and Mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic proceduresCristina Viana-Niero
Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Departamento de Microbiologia, Imunologia e Parasitologia, Rua Botucatu, 862, São Paulo 04023 062, Brazil
J Clin Microbiol 46:850-5. 2008..abscessus...
- Mycobacterium sherrisii isolation from a patient with pulmonary diseaseEnrico Tortoli
Regional Reference Center for Mycobacteria, Careggi Hospital, 50134 Florence, Italy
Diagn Microbiol Infect Dis 57:221-3. 2007..One of our strains was responsible for pulmonary disease in a middle-aged non-HIV patient; thus, confirming the potential pathogenicity of this species previously reported only in an HIV-positive patient...
- [Characterization of two new pigmented mycobacteria isolates]Cengiz Cavusoglu
Ege Universitesi Tip Fakultesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Izmir
Mikrobiyol Bul 40:185-94. 2006..These data, in addition to their position in the phylogenetic tree, strongly support the status of novel species at least for Mycobacterium sp. G1368...
- Application of the hsp65 PRA method for the rapid identification of mycobacteria isolated from clinical samples in BelgiumAnandi Martin
Mycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat, 155, Antwerp, B 2000 Belgium
J Microbiol Methods 71:39-43. 2007..PRA was found useful in the identification of mycobacteria and simple to implement as a quick method in the laboratory...
- Development and evaluation of a multiplex PCR for rapid detection and differentiation of Mycobacterium tuberculosis complex members from non-tuberculous mycobacteriaEiman Mokaddas
Department of Microbiology, Kuwait University, Safat, Kuwait
Jpn J Infect Dis 60:140-4. 2007..The mPCR developed in this study allowed rapid detection and differentiation of primary cultures as MTC or NTM, thus helping in timely institution of specific therapy...
- Comparative evaluation of the in vitro antimycobacterial activities of six aminoglycoside antibiotics using an agar dilution methodT Udou
Department of Clinical Microbiology, University of Occupational and Environmental Health, Kitakyushu, Japan
J Chemother 18:610-6. 2006....
- Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysisD Gupta
Dept of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
Eur Respir J 30:508-16. 2007..To avoid methodological diversity, larger multicentre trials with a central laboratory for sample testing should be designed...
- Evaluation of the GenoType MTBC assay for differentiating 120 clinical Mycobacterium tuberculosis complex isolatesI K Neonakis
Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Mycobacteriology Laboratory, University Hospital of Heraklion, Heraklion, Crete, 71201, Greece
Eur J Clin Microbiol Infect Dis 26:151-2. 2007
- Infections caused by Mycobacterium avium subspecies avium, hominissuis, and paratuberculosis in free-ranging red deer (Cervus elaphus hippelaphus) in Austria, 2001-2004Walter Glawischnig
Institute of Veterinary Medicine, Austrian Agency for Health and Food Safety, A 6020 Innsbruck, Austria
J Wildl Dis 42:724-31. 2006..In contrast, IS901-negative isolates (M. a. hominissuis) displayed distinct profiles in both molecular systems...
- A simple method to differentiate between Mycobacterium tuberculosis and non-tuberculous mycobacteria directly on clinical specimensMandira Varma Basil
Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
Southeast Asian J Trop Med Public Health 38:111-4. 2007..tuberculosis and its effective differentiation from NTM, which may be adapted for use at Level II laboratories, especially in developing countries...
- Applications of real-time PCR technology to mycobacterial researchDeepti Parashar
National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR, Agra, India
Indian J Med Res 124:385-98. 2006....
- Insights into early mycobacterial pathogenesis from the zebrafishRobin Lesley
Department of Microbiology, Box 357242, 1959 NE Pacific Street, University of Washington, Seattle, WA 98195, United States
Curr Opin Microbiol 11:277-83. 2008..As these studies uncover new facets of the bacteria-host interactions in tuberculosis they raise even more questions for future investigation...
- Multiphasic approach reveals genetic diversity of environmental and patient isolates of Mycobacterium mucogenicum and Mycobacterium phocaicum associated with an outbreak of bacteremias at a Texas hospitalRobert C Cooksey
Mycobacteriology Laboratory Branch, Centers for Disease Control and Prevention, Mail Stop F08, Atlanta, GA 30333, USA
Appl Environ Microbiol 74:2480-7. 2008..S. hospital. The investigation highlights important differences in the available typing methods for mycobacteria and demonstrates the genetic diversity of these organisms even within narrow confines of time and space...
- Spectrum of mycobacterial infections: tuberculosis and Mycobacterium other than tuberculosis in dialysis patientsAnna Basok
Department of Nephrology, Soroka University Hospital and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Isr Med Assoc J 9:448-51. 2007..Patients with end-stage renal disease are at high risk of mycobacterial infection...
- Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune responseT Mustafa
Section for Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen, Norway
Clin Exp Immunol 150:105-13. 2007..Correlation of MPT64 antigen with expression of macrophage deactivating cytokines and reduced apoptosis suggests its role in pathogenesis and bacillary persistence...
- Causes of and clinical sequelae of delays in reporting species identification of mycobacteria other than Mycobacterium tuberculosis and Mycobacterium avium complexSay Tat Ooi
Section of Infectious Diseases, Temple University School of Medicine, Philadelphia, PA 19140, USA
Diagn Microbiol Infect Dis 55:69-73. 2006..We show that the results of positive cultures of these mycobacteria are effectively lost because they are not available in a timely fashion, and even when available, the results are overlooked...
- Interaction of pathogenic mycobacteria with the host immune systemEdith N G Houben
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Curr Opin Microbiol 9:76-85. 2006..In addition, the definition of key molecules that are important for intracellular survival opens the possibility to develop new drugs to combat mycobacterial diseases...
- Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysisLinda M Parsons
Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
J Clin Microbiol 40:2339-45. 2002..bovis and M. tuberculosis, when it is important to distinguish between zoonotic sources (i.e., cattle and unpasteurized dairy products) and human sources of tuberculosis disease...
- Rapid differentiation of "Mycobacterium canettii" from other Mycobacterium tuberculosis complex organisms by PCR-restriction analysis of the hsp65 geneK S Goh
, Institut Pasteur de Guadeloupe, BP 484, , Guadeloupe
J Clin Microbiol 39:3705-8. 2001..tuberculosis H37Rv. Considering that "M. canettii" may also exist as a stable rough morphotype, we suggest that the true number of "M. canettii" isolates may be underestimated in clinical microbiology laboratories...
- PCR-based method to differentiate the subspecies of the Mycobacterium tuberculosis complex on the basis of genomic deletionsRichard C Huard
Division of International Medicine and Infectious Diseases, Department of Medicine, Joan and Sanford I. Weill Medical College, Cornell University, New York, New York 10021, USA
J Clin Microbiol 41:1637-50. 2003..It has proven beneficial in the management of Mycobacterium collections and may be applied for practical clinical and epidemiological use...
- Identification of 54 mycobacterial species by PCR-restriction fragment length polymorphism analysis of the hsp65 geneF Brunello
Dipartimento di Patologia, Sezione di Microbiologia, , Italy
J Clin Microbiol 39:2799-806. 2001....
- Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern MalawiG F Black
Karonga Prevention Study, Chilumba, Malawi
J Infect Dis 184:322-9. 2001..Although not statistically significant, the trend is consistent with the hypothesis that prior exposure to environmental mycobacteria interferes with immune responses to BCG vaccination...
- Evaluation of genotype MTBC assay for differentiation of clinical Mycobacterium tuberculosis complex isolatesElvira Richter
Forschungszentrum Borstel, National Reference Center for Mycobacteria, D 23845 Borstel, Germany
J Clin Microbiol 41:2672-5. 2003..M. bovis subsp. bovis, M. bovis subsp. caprae, M. bovis BCG, M. africanum subtype I, and M. microti were unequivocally identified. M. tuberculosis, M. canetti, and M. africanum subtype II showed a unique hybridization pattern...
- Comparison of a multiplex-PCR assay with mycolic acids analysis and conventional methods for the identification of mycobacteriaIoshie Ibara Tanaka
, , SP, Brazil
Microbiol Immunol 47:307-12. 2003..The multiplex-PCR method may offer expeditious identification of MTC and M. avium, which may minimize risks for active transmission of these organisms and provide useful treatment information...
- Detection of mycobacterial DNA in Andean mummiesNami Konomi
Department of Pathology, Mount Sinai School of Medicine, New York, New York 10021, USA
J Clin Microbiol 40:4738-40. 2002..This study confirmed the adequate preservation of genetic material in mummified tissues and the existence of mycobacteria, including M. tuberculosis, in historic populations in South America...
- Multicenter evaluation of the fully automated bactec MGIT 960 system and three molecular methods for the isolation and the identification of mycobacteria from clinical specimensF Kontos
Department of Microbiology, Medical School, University Hospital of Larissa, Papakyriazi 22, Larissa, Greece
Diagn Microbiol Infect Dis 46:299-301. 2003..The MGIT recovered 243 from 266 mycobacterial isolates. The PCR-based assay correctly identified all (234) Mycobacterium tuberculosis isolates, while 35 nontuberculous mycobacterial isolates were identified by PRA...
- Rapid differentiation between clinically relevant mycobacteria in microscopy positive clinical specimens and mycobacterial isolates by line probe assayIsik Somuncu Johansen
International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark
Diagn Microbiol Infect Dis 43:297-302. 2002..intracellulare as found by the conventional tests. The assay allows rapid discrimination of the eight most clinically relevant mycobacteria in microscopy positive clinical specimens and isolates within 6 h in the same procedural run...
- Novel algorithm identifies species in a polymycobacterial sample by fluorescence capillary electrophoresis-based single-strand conformation polymorphism analysisTomotada Iwamoto
Department of Bacteriology, Kobe Institute of Health, 4 6 Minatojima Nakamachi, Chuo Ku, Kobe 650 0046, Japan
J Clin Microbiol 40:4705-12. 2002..abscessus and M. kansasii, which are not targeted by Amplicor. FCE-RF-SSCP of sputum obtained from a patient with mixed M. avium and M. intracellulare infection gave SSCP patterns corresponding to these two species...
- Simultaneous identification of Mycobacterium genus and Mycobacterium tuberculosis complex in clinical samples by 5'-exonuclease fluorogenic PCRAlbert Garcia-Quintanilla
Departament de Microbiologia i Parasitologia Sanitaries, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
J Clin Microbiol 40:4646-51. 2002..In conclusion, we believe this test may be useful for the rapid detection of mycobacteria in clinical samples and may be a valuable tool when used together with conventional methods and the clinical data available...
- Rapid-cycle PCR and fluorimetry for detection of mycobacteriaJacqueline Lachnik
Institute of Medical Microbiology, Medical School Hannover, 30625 Hannover, Germany
J Clin Microbiol 40:3364-73. 2002....
- Reliability of hsp65-RFLP analysis for identification of Mycobacterium species in cultured strains and clinical specimensVanda Dolabela de Magalhães
Laboratório de Pesquisa e Desenvolvimento, Instituto de Ensino e Pesquisa, Hospital Israelita Albert Einstein, Av Albert Einstein 627, 05651 901, Sao Paulo SP, Brazil
J Microbiol Methods 49:295-300. 2002....
- Application of a simple multiplex PCR to aid in routine work of the mycobacterium reference laboratoryD Yeboah-Manu
Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
J Clin Microbiol 39:4166-8. 2001..In addition, this approach was incorporated into a multiplex PCR that included primers specific for IS6110 and the 65-kDa antigen gene in order to differentiate members of the M. tuberculosis complex from atypical mycobacteria...
- Evaluation of genotype and LiPA MYCOBACTERIA assays for identification of Finnish mycobacterial isolatesJohanna Mäkinen
National Public Health Institute Turku Graduate School of Biomedical Sciences Department of Medical Microbiology, University of Turku, Turku, Finland
J Clin Microbiol 40:3478-81. 2002..The LiPA assay correctly identified 89.4% of the 66 isolates studied, and the GenoType assay identified 95.1% of 81 isolates. The GenoType assay had a wider selection of species and less stringent temperature requirements...
- [Mycolic acids analysis from various species mycobacterium by high pressure liquid chromatography (HPLC)]Aleksandra Safianowska
Pneumonol Alergol Pol 70:130-8. 2002..tuberculosis complex and M. bovis BCG. The prepared library comprising 28 reference elution profiles of mycolic acids from known mycobacteria species can be applied in diagnostic procedure of tuberculosis and mycobacteriosis...
- Two-dimensional bacterial genome display: a method for the genomic analysis of mycobacteriaEdith M Dullaghan
The Division of Infectious and Immunological Diseases, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
Microbiology 148:3111-7. 2002..That 2DBGD can be used to identify differences resulting from either insertional mutagenesis using a gentamicin-resistance gene or from a frameshift mutation is demonstrated...
- Alveolar macrophage and mycobacteriaRajamouli Pasula; Fiscal Year: 2007..abstract_text> ..
- Mentoring in Tuberculosis Patient-Oriented ResearchNeil Schluger; Fiscal Year: 2007..abstract_text> ..
- Training in Translational Lung ResearchNeil Schluger; Fiscal Year: 2007..abstract_text> ..
- STRUCTURE OF LAM IN RELATION TO BIOLOGY AND BIOSYNTHESISDelphi Chatterjee; Fiscal Year: 2007..smegmatis and M. tuberculosis all in relation to biology and biosynthesis. ..
- Environmental cues and responses in tuberculosisDavid Russell; Fiscal Year: 2007....
- Host defense functions of M. tuberculosis lipoglycanEdward Chan; Fiscal Year: 2005..3. To elucidate the role of the TLRs, MAPK and NFkB signaling pathways, and ManLAM in controlling the growth of M. tuberculosis in mouse and human macrophages and to correlate effects on growth with NO* and TNFa expression. ..
- Zeiss LSM510 Meta Confocal MicroscopeDavid Russell; Fiscal Year: 2007..These data will extend ongoing, NIH-funded programs for identification of new drug targets, vaccines and adjuvants. ..
- Investigation of the role of bacteria in the sarcoidosis trimolecular complexWonder Drake; Fiscal Year: 2007....
- Role of mycobacteria in sarcoidosis immunopathogenesisWonder Drake; Fiscal Year: 2009..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..
- Cell Biology of Mycobacterium tuberculosis InfectionDavid G Russell; Fiscal Year: 2010..tuberculosis. We propose determining how the bacterium's metabolism is realigned to access these carbon sources. ..
- T cell memory to TB in the lungAndrea M Cooper; Fiscal Year: 2010..These new cell types may improve the protective effect of vaccines and thereby reduce the incidence of tuberculosis in the world. This will have a significant impact in worldwide public health. ..
- Enviromental cues and responses in tuberculosisDavid G Russell; Fiscal Year: 2010..abstract_text> ..
- Development of a Novel Strategy of Adjuvant DiscoveryDavid Russell; Fiscal Year: 2009..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
- Impact of chronic infection in the aged on the response to vaccinationAndrea Cooper; Fiscal Year: 2007..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. ..
- Immunotherapeutics and vaccines against anthrax, plague and tularemiaZheng Chen; Fiscal Year: 2007....
- Role of SOCS proteins in host-pathogen responsesPeter Murray; Fiscal Year: 2003..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
- GENES ASSOCIATED WITH M AVIUM PATHOGENESISLuiz Bermudez; Fiscal Year: 2002..The applicants believe that the studies outlined in this proposal will provide excellent tools for the identification of novel genes associated with mechanisms of pathogenesis of M. avium.m. ..
- IMMUNOPATHOGENESIS OF MYCOBACTERIUM AVIUM DISEASEAndrea Cooper; Fiscal Year: 2001..Finally, they will test the hypothesis that appropriate chemotherapy can restore the correct immunologic functions/signals, using both established regimens, as well as new compounds recently identified in their laboratory as active. ..
- TB LAM AND AG--STRUCTURES CORRELATED WITH BIOLOGYDelphi Chatterjee; Fiscal Year: 2001..tuberculosis. The structural studies will directly aid the immunological studies by providing a wealth of LAM related molecules needed to decipher the structural characteristics necessary for recognition by T-cells and macrophages. ..
- GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPPDavid Russell; Fiscal Year: 2004..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
- Secondary infections during mycobacterial diseaseMatyas Sandor; Fiscal Year: 2004..The goal of this research is to understand the interaction of T cell responses controlling different infections. Hopefully, this will lead to better treatments of mycobacterial disease. ..
- The Link Between Anemia of Inflammation and Host DefenseSeth Rivera; Fiscal Year: 2007..The research has broad relevance to the management of Al during severe infections. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2010..New knowledge of how T cells regulate granulomas will lead to more efficient therapeutic manipulations of granulomatous diseases. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2010..New knowledge of how T cells regulate granulomas will lead to more efficient therapeutic manipulations of granulomatous diseases. ..
- GENETIC DISSECTION OF MYCOBACTERIAL INFECTIONErwin Schurr; Fiscal Year: 2005..tuberculosis through an exposed population. ..
- T CELLS IN GRANULOMATOUS IMMUNE RESPONSESMatyas Sandor; Fiscal Year: 2004..abstract_text> ..
- BD LSR II Blue Laser Flow cytometerMatyas Sandor; Fiscal Year: 2006..A new generation of flow cytometric assays is becoming available and our group of users would like to advance to the next level. ..
- Mycobacterial antigen compartmentalization & immunityMatyas Sandor; Fiscal Year: 2005..abstract_text> ..
- The Basis of Anthrax-Induced Vascular DamageJames Kirby; Fiscal Year: 2006..As part of this exploration, we hope to identify and test new therapeutic strategies. ..
- Role of non-tuberculous mycobacteria in lung diseaseJason Stout; Fiscal Year: 2006..Our findings will also assist clinicians in predicting which patients with NTM isolated from the respiratory tract will have NTM pulmonary disease. ..