central nervous system bacterial infections

Summary

Summary: Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.

Top Publications

  1. ncbi Central nervous system infections
    Zoran Rumboldt
    Department of Radiology, Medical University of South Carolina, 169 Ashley Avenue, Charleston, SC 29425, USA
    Semin Roentgenol 42:62-91. 2007
  2. ncbi A child with neurobrucellosis
    A C Hesseling
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Western Cape Province, South Africa
    Ann Trop Paediatr 23:145-8. 2003
  3. ncbi Intracranial infection associated with preseptal and orbital cellulitis in the pediatric patient
    Dorothy J Reynolds
    Department of Ophthalmology, North Shore Long Island Jewish Health System, Great Neck, NY, USA
    J AAPOS 7:413-7. 2003
  4. ncbi Cranial bacterial infection
    Philip Anslow
    Department of Neuroradiology, Racliffe Infirmary, Oxford, OX2 6HE, UK
    Eur Radiol 14:E145-54. 2004
  5. ncbi Primary Whipple's disease of the brain: characterization of the clinical syndrome and molecular diagnosis
    P K Panegyres
    Neurodegenerative Disorders Research, Suite 33, 146 Mounts Bay Road, Perth WA 6000, Australia
    QJM 99:609-23. 2006
  6. ncbi [Transverse myelitis associated with cat-scratch disease]
    Antoni Turon Estrada
    Med Clin (Barc) 120:437. 2003
  7. ncbi Nocardiosis with brain abscess due to an unusual species, Nocardia transvalensis
    Rebecca F Yorke
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Pathol Lab Med 127:224-6. 2003
  8. pmc Trends in encephalitis-associated deaths in the United States
    N Khetsuriani
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Atlanta, GA 30333, USA
    Epidemiol Infect 135:583-91. 2007
  9. ncbi Serial imaging changes of cerebral Whipple's disease: from onset to the end
    Changliang Yu
    Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
    J Neuroimaging 17:81-3. 2007
  10. ncbi [Neurolisteriosis in adults: report of six clinical cases]
    Ronald Salamano
    Instituto de Neurologia, Facultad de Medicina, Montevideo, Uruguay
    Arq Neuropsiquiatr 63:1063-9. 2005

Detail Information

Publications113 found, 100 shown here

  1. ncbi Central nervous system infections
    Zoran Rumboldt
    Department of Radiology, Medical University of South Carolina, 169 Ashley Avenue, Charleston, SC 29425, USA
    Semin Roentgenol 42:62-91. 2007
  2. ncbi A child with neurobrucellosis
    A C Hesseling
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Western Cape Province, South Africa
    Ann Trop Paediatr 23:145-8. 2003
    ..Nerve conduction studies confirmed a proximal radiculopathy. Awareness of the condition and performance of the appropriate tests will differentiate neurobrucellosis from other chronic central nervous system infections...
  3. ncbi Intracranial infection associated with preseptal and orbital cellulitis in the pediatric patient
    Dorothy J Reynolds
    Department of Ophthalmology, North Shore Long Island Jewish Health System, Great Neck, NY, USA
    J AAPOS 7:413-7. 2003
    ..To identify risk factors in children admitted with preseptal or orbital cellulitis with associated intracranial infection...
  4. ncbi Cranial bacterial infection
    Philip Anslow
    Department of Neuroradiology, Racliffe Infirmary, Oxford, OX2 6HE, UK
    Eur Radiol 14:E145-54. 2004
    ..A series of cases is presented to illustrate the role of imaging in infective disease and to draw attention to diagnostic and management points of which radiologists should be aware...
  5. ncbi Primary Whipple's disease of the brain: characterization of the clinical syndrome and molecular diagnosis
    P K Panegyres
    Neurodegenerative Disorders Research, Suite 33, 146 Mounts Bay Road, Perth WA 6000, Australia
    QJM 99:609-23. 2006
    ..Whipple's disease (WD) of the brain without evidence of systemic involvement is a rare illness that is difficult to recognize and potentially life-threatening...
  6. ncbi [Transverse myelitis associated with cat-scratch disease]
    Antoni Turon Estrada
    Med Clin (Barc) 120:437. 2003
  7. ncbi Nocardiosis with brain abscess due to an unusual species, Nocardia transvalensis
    Rebecca F Yorke
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Pathol Lab Med 127:224-6. 2003
    ..Familiarity with the epidemiology, pathologic findings, and clinical significance of this and other unusual Nocardia species may increase early identification and antibiotic susceptibility testing in cases of nocardial infection...
  8. pmc Trends in encephalitis-associated deaths in the United States
    N Khetsuriani
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Atlanta, GA 30333, USA
    Epidemiol Infect 135:583-91. 2007
    ..HIV infection was largely responsible for the lack of overall decline in the considerable mortality associated with encephalitis in the United States during 1979-1998...
  9. ncbi Serial imaging changes of cerebral Whipple's disease: from onset to the end
    Changliang Yu
    Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
    J Neuroimaging 17:81-3. 2007
    ..A case with multiple cerebral Whipple disease is reported. The neuroradiological evolution from multiple macrophagic encephalitis to diffuse cerebral infarct in this case is described...
  10. ncbi [Neurolisteriosis in adults: report of six clinical cases]
    Ronald Salamano
    Instituto de Neurologia, Facultad de Medicina, Montevideo, Uruguay
    Arq Neuropsiquiatr 63:1063-9. 2005
    ..It presents most commonly as an acute meningitis, although it can present itself as cerebritis, brain stem encephalitis (rhomboencephalitis), and exceptionally as myelitis...
  11. ncbi Strategies for the management of bacterial brain abscess
    Cheng Hsien Lu
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan
    J Clin Neurosci 13:979-85. 2006
    ....
  12. ncbi Spinal epidural abscess successfully treated with percutaneous, computed tomography-guided, needle aspiration and parenteral antibiotic therapy: case report and review of the literature
    Rong Kuo Lyu
    Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Neurosurgery 51:509-12; discussion 512. 2002
    ..We describe a case of a posterior spinal epidural abscess that was successfully treated with percutaneous, computed tomography-guided, needle aspiration and parenteral antibiotic therapy...
  13. ncbi Clinical and laboratory findings in neurobrucellosis: review of 31 cases
    Mahboubeh Haji-Abdolbagi
    Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran
    Arch Iran Med 11:21-5. 2008
    ....
  14. doi Risk factors for infections related to external ventricular drainage
    D Hoefnagel
    Erasmus Medical Centre, Department of Neurosurgery, Rotterdam, The Netherlands
    Acta Neurochir (Wien) 150:209-14; discussion 214. 2008
    ..The major complication of this procedure is an EVD-related infection, i.e., meningitis or ventriculitis. The purpose of the present retrospective single centre study is to assess the possible causes of these infections...
  15. ncbi Spectra of central nervous system melioidosis
    Kalai Arasu Muthusamy
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, United Kingdom
    J Clin Neurosci 14:1213-5. 2007
    ..All these patients underwent surgical drainage leading to bacteriological diagnosis as well as appropriate long-term antibiotic therapy. All had good recovery at 6 months after completion of treatment...
  16. ncbi Management of neurobrucellosis: an assessment of 11 cases
    Hanefi Cem Gul
    Department of Infectious Diseases and Clinical Microbiology, Gulhane Military Hospital, Ankara, Turkey
    Intern Med 47:995-1001. 2008
    ..The central nervous system involvement of Brucellosis causes a hard to treat infection with multiple sequelae. The aim of this paper is to discuss the course of neurobrucellosis in response to therapy...
  17. ncbi A quadriplegic child with multiple brain abscesses: case report of neurobrucellosis
    Zarrin Keihani-Douste
    Department of Pediatrics, Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran
    Med Sci Monit 12:CS119-122. 2006
    ..This report presents a child with spinal cord lesion with concomitant multiple brain abscesses caused by brucellosis...
  18. ncbi [Corpus callosum pathological lesions in computed tomography and magnetic resonance imaging]
    M Bekiesinska-Figatowska
    Zakładu Diagnostyki Obrazowej Centralnego Szpitala Kolejowego i Centrum Medycznego Kształcenia Podyplomowego w Warszawie
    Neurol Neurochir Pol 35:829-40. 2001
    ..CT and MR images from the authors' own experience illustrate the material...
  19. ncbi External ventricular drain infection: the effect of a strict protocol on infection rates and a review of the literature
    D Dasic
    Department of Neurological Surgery, Radcliffe Infirmary, Oxford, UK
    Br J Neurosurg 20:296-300. 2006
    ..This study demonstrates that adherence to an evidence-based protocol for their insertion and management is associated with a significant reduction in the infection rate...
  20. ncbi Variable presentation of neurological melioidosis in Northeast Thailand
    Direk Limmathurotsakul
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 77:118-20. 2007
    ..The appropriate duration and choice of parenteral and oral antimicrobial therapy for neurologic melioidosis are also discussed...
  21. ncbi [Whipple disease and central nervous system]
    Pedro Abreu
    Servico de Neurologia, Hospital de S Joao, Porto
    Acta Med Port 18:199-208. 2005
    ..We alert for the early diagnosis of WD in patients with exclusively neurological clinical pictures, sometimes with atypical or non-definitive diagnosis, because it is a potential treatable disease...
  22. ncbi [Case report: subdural hemorrhage in neurobrucellosis]
    Günay Tuncer Ertem
    S B Ankara Eğitim ve Araştirma Hastanesi, Infeksiyon Hastaliklari ve Klinik Mikrobiyoloji Klinigi, Ankara
    Mikrobiyol Bul 38:253-6. 2004
    ..The case deserved presentation and discussion since it presented with subdural hemorrhage which is a rare complication of neurobrucellosis...
  23. ncbi Presence of Chlamydophila psittaci DNA in the central nervous system of a patient with status epilepticus
    Gernot Walder
    Institute of Hygiene and Social Medicine, University of Innsbruck, Austria
    Scand J Infect Dis 35:71-3. 2003
    ..Direct invasion of the central nervous system by Chlamydophila psittaci was confirmed by the demonstration of specific DNA in the patient's cerebrospinal fluid. The patient recovered slowly under administration of doxycycline...
  24. ncbi Intracranial infection due to non-typhoidal Salmonella: report of four cases
    R Bellamy
    J Infect 44:207-8. 2002
  25. ncbi Cure of multiresistant Acinetobacter baumannii central nervous system infections with intraventricular or intrathecal colistin: case series and literature review
    John Ng
    Department of Microbiology and Infectious Diseases, South Western Area Pathology Service, Liverpool, Sydney, New South Wales, Australia
    J Antimicrob Chemother 58:1078-81. 2006
    ..Colistin remains one of the few remaining treatment options for MRAB but has poor CNS penetration. We describe our experience with intraventricular or intrathecal colistin for this infection...
  26. pmc Successful treatment of multidrug-resistant Acinetobacter baumannii central nervous system infections with colistin
    Aspasia Katragkou
    J Clin Microbiol 43:4916-7. 2005
  27. ncbi Nocardiosis: a review
    Marcelo E Corti
    Unit 10, Infectious Diseases, FJ Muñiz Hospital, Buenos Aires, Argentina
    Int J Infect Dis 7:243-50. 2003
    ..The treatment of nocardiosis also requires expertise. This report reviews the epidemiology, physiopathology, clinical manifestations, diagnosis and treatment of this aerobic bacterial disease...
  28. ncbi [Meningitis due to Streptococcus bovis biotype II. Clinical case and review of the literature]
    José Manuel Barragán-Casas
    Enferm Infecc Microbiol Clin 20:537-8. 2002
  29. doi Central nervous system infections and epilepsy
    Gagandeep Singh
    Department of Neurology, Dayanand Medical College, Ludhiana, India
    Epilepsia 49:1. 2008
  30. ncbi Problem pathogens: extra-intestinal complications of Salmonella enterica serotype Typhi infection
    David B Huang
    Center for Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA
    Lancet Infect Dis 5:341-8. 2005
    ..We describe the epidemiology, clinical manifestations, pathogenesis, and treatment of extra-intestinal S typhi infections...
  31. ncbi Central nervous system Lyme disease
    John J Halperin
    Department of Neurology, North Shore University Hospital, Manhasset, NY 11030, USA
    Curr Neurol Neurosci Rep 5:446-52. 2005
    ..Several well-performed studies have clearly shown that prolonged antimicrobial treatment of "post-Lyme disease" is ineffective. Diagnosis and treatment of Lyme disease continue to improve...
  32. ncbi Obsessive-compulsive disorder following brain injury: a review
    Bernardus R Coetzer
    North Wales Brain Injury Service, Conwy and Denbighshire NHS Trust, Colwyn Bay Hospital, United Kingdom
    Int J Psychiatry Med 34:363-77. 2004
    ..However, the first onset of obsessions and compulsions following a brain injury has been described, but cognitive impairments can potentially color the presentation...
  33. ncbi Neuroimage: disseminated nocardiosis
    P K Sethi
    Clin Neurol Neurosurg 110:98-100. 2008
  34. ncbi Molecular mechanisms of axonal damage in inflammatory central nervous system diseases
    Harald Neumann
    Neuroimmunology Unit, European Neuroscience Institute Göttingen, Gottingen, Germany
    Curr Opin Neurol 16:267-73. 2003
    ..Axonal injury has attracted considerable interest during the past few years because the degree of axonal damage appears to determine long-term clinical outcome...
  35. ncbi Glycoconjugates: roles in neural diseases caused by exogenous pathogens
    Cara Lynne Schengrund
    The Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, 17033, USA
    CNS Neurol Disord Drug Targets 5:381-9. 2006
    ....
  36. ncbi Expression of neurotrophic factors in cerebrospinal fluid and plasma of children with viral and bacterial meningoencephalitis
    A Chiaretti
    Paediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy
    Acta Paediatr 93:1178-84. 2004
    ....
  37. ncbi Glucocorticoids in central nervous system bacterial infection
    P K Coyle
    Department of Neurology, State University of New York at Stony Brook, 11794, USA
    Arch Neurol 56:796-801. 1999
    To evaluate evidence-based data on adjunctive glucocorticoid therapy in central nervous system bacterial infections.
  38. doi Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neuropathol Exp Neurol 67:1041-54. 2008
    ..Together, these results suggest that cathelicidins produced by glia and other cells play an important part in the innate immune response against pathogens in central nervous system bacterial infections.
  39. ncbi An unusual case of neurobrucellosis presenting as demyelination disorder
    Omer Bektas
    Division of Pediatric Neurology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 55:210-3. 2013
    ..Additionally, this case is the first in terms of involvement of the corpus callosum in neurobrucellosis. In this article, we present an unusual case of neurobrucellosis. ..
  40. doi Expanding the spectrum of MERS type 2 lesions, a particular form of encephalitis
    Anneleen Notebaert
    Department of Pediatric Neurology, Ghent University Hospital, Ghent, Belgium
    Pediatr Neurol 48:135-8. 2013
    ..In the article, previously reported patients with MERS type 2 lesions are reviewed...
  41. doi [MR imaging in the diagnosis of primary and secondary cerebral infections]
    K Krope
    Radiologie, Universitat Tubingen
    Rofo 185:539-45. 2013
    ..Both specific MR sequences and imaging characteristics of major cerebral infections are addressed in this overview. Furthermore, limitations and pitfalls of the method are discussed...
  42. ncbi Evaluation of children with neurobrucellosis
    S Akbayram
    Department of Pediatrics, Yuzuncu Yil University, Van, Turkey
    Bratisl Lek Listy 113:424-30. 2012
    ..Central nervous system involvement is a serious complication of brucellosis with a ratio of 4-11% of all patients. Aim: to describe our experience in diagnosis, treatment, and outcome of 25 pediatric patients with neurobrucellosis...
  43. doi Co-infection of HIV and tropical infectious agents that affect the nervous system
    L Chimelli
    Division of Pathology, National Institute of Cancer, Rua Cordeiro da Graça 156, Santo Cristo, Rio de Janeiro, RJ, CEP 20220 400, Brazil
    Rev Neurol (Paris) 168:270-82. 2012
    ..This article reviews some of the key diagnostic aspects of tropical infections associated with HIV infection...
  44. doi Neurobrucellosis: clinical and diagnostic features
    Tumer Guven
    Infectious Diseases and Clinical Microbiology Clinic, Ataturk Training and Research Hospital, Ankara, Turkey
    Clin Infect Dis 56:1407-12. 2013
    ..We describe the neurological involvement in brucellosis and revisited diagnostic criteria for neurobrucellosis...
  45. pmc Neurologic complications of HIV-1 infection and its treatment in the era of antiretroviral therapy
    Sarah M Kranick
    National Institutes of Health, Building 10, 6 5700, Bethesda, MD 20892, USA
    Continuum (Minneap Minn) 18:1319-37. 2012
    ..Additionally, as successful virologic control has extended the life span of patients with HIV infection, neurologists are called upon to manage long-term complications, such as neurocognitive disorders and peripheral neuropathy...
  46. ncbi Staphylococcus aureus brainstem abscess in a Brazilian Amazon man. Case report
    de Nazareth Hermes
    Department of Neurosurgery, Hospital Ophir Loyola, Belem, Para, Brazil
    J Neurosurg Sci 55:383-5. 2011
    ..This case reinforces the importance of an early suspicion of BSA in patients with unexplained fever and neurologic deficits, especially sixth and seventh cranial nerve lesions, to minimize permanent damage...
  47. pmc Lymphocyte apoptosis in children with central nervous system tuberculosis: a case control study
    Paola Di Carlo
    Department of Sciences for Health Promotion, University of Palermo, via del Vespro 133, Palermo I 90127, Italy
    BMC Pediatr 11:108. 2011
    ....
  48. pmc Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis
    Solène Grayo
    Laboratoire de Listeria, Centre National de Référence des Listeria, World Health Organization Collaborating Centre for Foodborne Listeriosis, Institut Pasteur, Paris, France
    Antimicrob Agents Chemother 52:3210-5. 2008
    ..Our results indicate that moxifloxacin combines useful pharmacokinetic properties and rapid bactericidal activity and that it may be a valuable alternative for the treatment of CNS listeriosis...
  49. doi Spectrum of CNS disease caused by rapidly growing mycobacteria
    Naasha J Talati
    Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA
    Lancet Infect Dis 8:390-8. 2008
    ..Treatment requires a long course of two or more antibiotics that have the ability to penetrate the blood-brain barrier, and possibly of steroids as immunomodulatory agents, such as those used in tuberculous meningitis...
  50. doi Linezolid in postneurosurgical infections
    B Maure
    Infection 36:82-3. 2008
  51. doi Bilingual aphasia due to spontaneous acute subdural haematoma from a ruptured intracranial infectious aneurysm
    Girish V Vajramani
    Department of Neurosurgery, Wessex Neurological Centre, Southampton General Hospital, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Clin Neurol Neurosurg 110:823-7. 2008
    ..The neurology of language in a bilingual is analysed and possible mechanisms discussed...
  52. doi Massive ascites as unique sign of shunt infection by Propionibacterium acnes
    Nicola Montano
    Institute of Neurosurgery, Catholic University, Rome
    Br J Neurosurg 24:221-3. 2010
    ..We report on a case of P. acnes shunt infection presenting with massive ascites as the unique sign of CSF infection. Shunt removal, antibiotic therapy and drenaige of ascites were performed with a rapid clinical recovery...
  53. doi Cerebellar abscesses in children: excision or aspiration?
    Paritosh Pandey
    Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India
    J Neurosurg Pediatr 1:31-4. 2008
    ..There is still no consensus on the standard approach to these lesions, and controversy persists over whether these lesions should be treated with primary excision or aspiration...
  54. doi Cerebrospinal fluid shunt infections in children over a 13-year period: anaerobic cultures and comparison of clinical signs of infection with Propionibacterium acnes and with other bacteria
    Kai Arnell
    Department of Pediatric Surgery, Uppsala University Hospital, Uppsala, Sweden
    J Neurosurg Pediatr 1:366-72. 2008
    ....
  55. doi New diagnostic tools for central nervous system infection
    Wendy C Ziai
    Curr Opin Neurol 21:338-41. 2008
  56. doi Bartonella-associated meningoradiculoneuritis and dermatitis or panniculitis in 3 dogs
    J R Cross
    Department of Small Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    J Vet Intern Med 22:674-8. 2008
  57. doi Pathogenesis of septic encephalopathy
    Peter Pytel
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Curr Opin Neurol 22:283-7. 2009
    ..Here, we review recent advances in our understanding of septic encephalopathy, from molecular mechanisms to behavioral alterations, from diagnostic tools to potential therapeutic agents...
  58. doi Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease?
    Kie Honjo
    L C Campbell Cognitive Neurology Research Unit, Heart and Stroke Foundation Centre for Stroke Recovery, Section of Neurology, Department of Medicine, Sunnybrook Health Science Centre and University of Toronto, Toronto, Ontario, Canada
    Alzheimers Dement 5:348-60. 2009
    ..If this hypothesis holds true, early intervention against infection may delay or even prevent the future development of AD...
  59. doi Impact of intracranial pressure monitor prophylaxis on central nervous system infections and bacterial multi-drug resistance
    Nathaniel F Stoikes
    Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Surg Infect (Larchmt) 9:503-8. 2008
    ..We tested the hypothesis that prophylactic antibiotics do not reduce the incidence of central nervous system (CNS) infections but instead are associated with the acquisition of multi-drug resistant (MDR) bacterial infections...
  60. doi Overview of neurobrucellosis: a pooled analysis of 187 cases
    Hanefi Cem Gul
    Department of Infectious Diseases and Clinical Microbiology, Gulhane Medical Academy, Ankara, Turkey
    Int J Infect Dis 13:e339-43. 2009
    ..5% with suitable antibiotics. Neurobrucellosis may mimic various pathologies. For this reason, a thorough evaluation of the patient with probable disease is crucial for an accurate diagnosis and proper management of the disease...
  61. doi Antibiotics-impregnated ventricular catheter versus systemic antibiotics for prevention of nosocomial CSF and non-CSF infections: a prospective randomised clinical trial
    George K C Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    J Neurol Neurosurg Psychiatry 81:1064-7. 2010
    ..This study aims to compare antibiotic impregnated catheters with conventional catheters coupled with systemic antibiotics...
  62. doi Central nervous system infection with Staphylococcus intermedius secondary to retrobulbar abscessation in a dog
    James A C Oliver
    Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hertfordshire SG5 3HR, UK
    Vet Ophthalmol 12:333-7. 2009
    ....
  63. doi Concomitant presentation of a glioblastoma multiforme with superimposed abscess
    David H Jho
    Neurosurgery Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    World Neurosurg 75:126-31; discussion 50-3. 2011
    ..In the present report we evaluate the diagnosis and treatment of a glioblastoma multiforme with an intratumoral abscess...
  64. doi Emerging therapeutic options in fulminant invasive rhinocerebral mucormycosis
    Kathrin Scheckenbach
    Department of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
    Auris Nasus Larynx 37:322-8. 2010
    ..Due to the lack of typical clinical signs, diagnosis relies on histopathology. Therapy consists of the management of predisposing factors, radical surgical intervention and systemic antifungal therapy...
  65. doi [Bacterial infections of the central nervous system]
    M Klein
    Neurologische Klinik und Poliklinik, Klinikum Grosshadern, Universitat Munchen, Marchioninistrasse 15, Munich
    Nervenarzt 81:150-61. 2010
    ..Here, the relevant diagnostic and therapeutic aspects of three common bacterial infections of the central nervous system (neuroborreliosis, bacterial meningitis, and brain abscess) are discussed...
  66. doi Burden of neuroinfectious diseases on the neurology service in a tertiary care center
    K Tan
    Department of Neurology, 509 Pathology, 600 N Wolfe St, Baltimore, MD, USA
    Neurology 71:1160-6. 2008
    ..We aimed to determine the burden of neurologic infections on the neurology service in a tertiary care center and identify challenges in the diagnosis and treatment of these infections...
  67. pmc NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens
    Vinita S Chauhan
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Glia 57:414-23. 2009
    ..As such, we have identified NOD2 as an important component in the generation of damaging CNS inflammation following bacterial infection...
  68. ncbi Secondary intracranial causes for headaches in children
    Rooman Ahad
    Department of Neurology, Division of Pediatric Neurology, Johns Hopkins Hospital, 200 N Wolfe Street, Baltimore, MD 21287, USA
    Curr Pain Headache Rep 12:373-8. 2008
    ..This article discusses these secondary causes of headaches due to primary brain etiologies, focusing on aspects of the history that should lead a neurologist to order neuroimaging or electroencephalographic studies for these children...
  69. doi The association between central nervous system (CNS) infections and epilepsy: epidemiological approaches and microbiological and epileptological perspectives
    Gagandeep Singh
    Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, India gagandeep
    Epilepsia 49:2-7. 2008
    ....
  70. doi Principles of antimicrobial therapy
    JEFFREY M TESSIER
    Virginia Commonwealth University, Richmond, 23298 0049, USA
    Handb Clin Neurol 96:17-29. 2010
    ..g., improved symptoms, lack of new neurological findings) and radiographic changes (e.g., reduction in cavity size)...
  71. ncbi Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region
    Nurgul Ceran
    Department of Infectious Diseases, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
    Braz J Infect Dis 15:52-9. 2011
    ..In inhabitants or visitors of endemic areas, neurobrucellosis should be kept in mind in cases that have unusual neurological manifestations...
  72. ncbi Obsessive-compulsive disorder after streptococcal infection in a frontal lobe-resected patient
    Lucas C Quarantini
    CNS Spectr 13:645-6. 2008
  73. doi [CNS infections in immunocompromised patients]
    K M Hartmann
    Abt für Diagnostische und Interventionelle Neuroradiologie, Radiologische Klinik, Universitatsklinikum des Saarlandes, 66421, Homburg Saar
    Radiologe 48:560-71. 2008
    ..This article gives a review of the most frequent infective agents and image alterations. Modern radiology is not yet able to replace the gold standard of pathogen detection...
  74. ncbi Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects
    Christina Dalman
    Department of Psychiatric Epidemiology, EPI Karolinska Institutet, Norrbacka pl 5, 171 76 Stockholm, Sweden
    Am J Psychiatry 165:59-65. 2008
    ..The present study aims to investigate whether there is an increased risk of schizophrenia and other nonaffective psychoses associated with viral or bacterial CNS infections during childhood and, if so, which specific agents are involved...
  75. ncbi Whipple disease confined to the central nervous system presenting as a solitary frontal tumor. Case report
    Mario Löhr
    Department of Neurosurgery, University of Cologne, Germany
    J Neurosurg 101:336-9. 2004
    ..A review of diagnostic and therapeutic options in suspected cases is presented...
  76. ncbi Isolated intracranial hypertension: a rare presentation of neurobrucellosis
    Handan Isin Ozisik
    Research Hospital, Turgut Ozal Medical Center, Inonu University Medical Faculty, TR 44330 Malatya, Turkey
    Microbes Infect 6:861-3. 2004
    ..This case demonstrated that brucella meningitis may present with very slight symptoms, and inoculation of CSF into BACTEC bottle besides conventional cultures improves the detection of Brucella in endemic areas such as Turkey...
  77. pmc Borrelia valaisiana in cerebrospinal fluid
    Eudoxia Diza
    Emerg Infect Dis 10:1692-3. 2004
  78. ncbi Diagnosis of bacterial cerebellitis: diffusion imaging and proton magnetic resonance spectroscopy
    Ramandeep S Jaggi
    Department of Neurosurgery, King George s Medical University, Lucknow, India
    Pediatr Neurol 32:72-4. 2005
    ..The child made a complete clinical and imaging recovery on conservative management...
  79. ncbi Defining bacterial meningitis and other infections of the central nervous system
    Gary D Overturf
    Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM, USA
    Pediatr Crit Care Med 6:S14-8. 2005
    ..To define central nervous system infections of infants and children that occur as co-morbid or predisposing conditions of sepsis...
  80. ncbi Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system whipple disease
    Jared W Nelson
    University of Iowa College of Medicine, Iowa City, IA 52246, USA
    J Comput Assist Tomogr 29:320-2. 2005
    ..Diffusion-weighted MRI and MRS offer noninvasive methods to help evaluate in vivo physiologic changes of CNS involvement in Whipple disease...
  81. ncbi Meropenem
    Dheeraj Shah
    Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110 095, India
    Indian Pediatr 42:443-50. 2005
    ..Due to concern relating to emergence of resistance, it should be used as a reserve drug in difficult-to-treat infections caused by resistant organisms or when conventional treatment fails...
  82. ncbi Clinical experience with linezolid for the treatment of central nervous system infections
    T A Rupprecht
    Department of Neurology, Ludwig Maximilian University, Munich, Germany
    Eur J Neurol 12:536-42. 2005
    ..Linezolid appears to be a safe alternative to vancomycin for therapy-resistant CNS infections because of its good CSF penetration and few side-effects...
  83. ncbi A severe headache
    Beau J Bagley
    LSU Health Sciences Center and Children s Hospital, Department of Pediatrics, New Orleans, Louisiana 70118, USA
    Clin Pediatr (Phila) 43:301-2. 2004
  84. ncbi Bug's life
    John McCrone
    Lancet Neurol 2:710. 2003
  85. ncbi Immune reactions to Listeria monocytogenes in the brain
    D Schluter
    Institut für Med Mikrobiologie und Hygiene, Universitat Heidelberg, Universitatsklinikum Mannheim, Germany
    Immunobiology 201:188-95. 1999
    ..The favorable prognosis of immunized mice correlated with a reduced intracerebral bacterial load, an increased recruitment of protective CD4+ and CD8+ T cells as well as an upregulated mRNA production of protective cytokines...
  86. ncbi Neurobrucellosis--a rare complication of renal transplantation
    B Yousif
    Clinical Medical Services Department, Saudi Aramco-Dhahran Health Center, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia
    Am J Nephrol 21:66-8. 2001
    ..Treatment with doxycycline and rifampin led to a clinical cure as well as to marked improvement in the Brucella titer...
  87. pmc Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis
    A Wellmer
    Departments of Neurology, , , Germany
    Infect Immun 69:6881-6. 2001
    ..Early leukocyte influx into the peritoneum was impaired in TNF-alpha-deficient mice. The lack of TNF-alpha or its receptors renders mice more susceptible to S. pneumoniae infections...
  88. ncbi Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells
    You hong Cui
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Building 560, Frederick, MD 21702, USA
    J Immunol 168:434-42. 2002
    ..Thus, LPS selectively modulates the function of chemoattractant receptors in microglia and may promote host response in inflammatory diseases in the CNS...
  89. ncbi Intracranial Salmonella infections: meningitis, subdural collections and brain abscess. A series of six surgically managed cases with follow-up results
    Ashok K Mahapatra
    Department of Neurosurgery, The National Neurosurgical Centre, Khoula Hospital, Mina Al Fahal, Muscat, Sultanate of Oman
    Pediatr Neurosurg 36:8-13. 2002
    ..This study suggests that a high index of suspicion, early diagnosis and quick evacuation lead to success; this point is highlighted with the help of a review of the literature...
  90. ncbi Cerebellar abscess due to Listeria monocytogenes
    Bassam M Addas
    Department of Surgery, King Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 23:226-8. 2002
    ..The diagnosis of listeria monocytogenes was made in the surgical specimen. Our case illustrates the difficulty of early diagnosis of cerebellar listeria monocytogenes abscesses and the importance of prompt neurosurgical intervention...
  91. ncbi Chlamydia pneumoniae and multiple sclerosis: the latest etiologic candidate
    Khurram Bashir
    Department of Neurology, University of Alabama at Birmingham, 220A Ryals Building, 1665 University Blvd, Birmingham, AL 35294 0022, USA
    Epidemiology 14:133-4. 2003
  92. ncbi Community-acquired Klebsiella pneumoniae central nervous system infections in adults in Singapore
    A G Habib
    Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074, Singapore, Singapore
    Eur J Clin Microbiol Infect Dis 22:486-8. 2003
    ....
  93. ncbi Invasive listeriosis in Denmark 1994-2003: a review of 299 cases with special emphasis on risk factors for mortality
    P Gerner-Smidt
    Danish Reference Centre for Listeriosis, Statens Serum Institut, Copenhagen, Denmark
    Clin Microbiol Infect 11:618-24. 2005
    ..The underlying conditions associated most strongly with mortality in the younger age group were non-haematological malignancies...
  94. ncbi A case of multiple cranial nerve palsy due to sphenoid sinusitis complicated by cerebral aneurysm
    Nobuhiro Suzuki
    Department of Otolaryngology, Tokyo Medical University, Shinjyuku ku, Nishishinjyuku, 6 7 1, Tokyo 160 0023, Japan
    Auris Nasus Larynx 32:415-9. 2005
    ..After endovascular coil placement, his right visual disturbance partially recovered...
  95. ncbi Treatment of neurobrucellosis: what is known and what remains to be answered
    Georgios Pappas
    Institute of Continuing Medical Education of Ioannina, H, Trikoupi 10, Ioannina 45333, Greece
    Expert Rev Anti Infect Ther 5:983-90. 2007
    ..Treatment duration should be individualized in the absence of an adequate cut-off index...
  96. ncbi Isolated CNS Whipple disease with a variant of oculofacial-skeletal myorhythmia (OFSM)
    D Ciampi de Andrade
    Department of Neurology, University of Sao Paulo, Brazil
    Neurology 69:E12. 2007
  97. pmc Minocycline modulates neuroinflammation independently of its antimicrobial activity in staphylococcus aureus-induced brain abscess
    Tammy Kielian
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 846, Little Rock, AR 72205, USA
    Am J Pathol 171:1199-214. 2007
    ..disease models; however, its potential to influence the host immune response during central nervous system bacterial infections, such as brain abscess, has not yet been investigated...
  98. ncbi Extended subcutaneous tunnelling technique for external ventricular drainage
    G K K Leung
    Division of Neurosurgery, Department of Surgery, Li Ka Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR, China
    Br J Neurosurg 21:359-64. 2007
    ..However, this is essentially an audit within a single centre, and the findings should be interpreted with caution and with the understanding that individual institutions may have their unique patterns and risks of EVD infection...
  99. ncbi [GEIPC-SEIMC and GTEI-SEMICYUC recommendations for antibiotic treatment of gram positive coccal infections in the critical patient]
    P M Olaechea Astigarraga
    Servicio de Medicina Intensiva, Hospital de Galdakao, Bo de Labeaga s n, 48960 Galdakao, Vizcaya, Spain
    Med Intensiva 31:294-317. 2007
    ....
  100. ncbi Subdural empyema caused by an unusual organism following intracranial haematoma
    Pieter C Le Roux
    Department of Paediatric Neurosurgery, Mater Children s Hospital, Brisbane, Queensland, Australia
    Childs Nerv Syst 23:825-7. 2007
    ..Subdural empyema is not commonly diagnosed in the developed world, occurring mostly after meningitis, sinusitis, trauma or surgery...
  101. ncbi External ventricular drain infections are independent of drain duration: an argument against elective revision
    Cheng H Lo
    Department of Neurosurgery, The Alfred Hospital, Melbourne, Victoria, Australia
    J Neurosurg 106:378-83. 2007
    ....

Research Grants31

  1. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..
  2. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  3. HIV-1 protein neurotoxicity and ethanol pre-conditioning
    Michael Collins; Fiscal Year: 2006
    ..abstract_text> ..
  4. Cryptococcus traversal of Brain Endothelial cells
    Kwang Kim; Fiscal Year: 2007
    ..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
  5. Effects of Neuroinflammation on Gap Junction Communication in Glia
    Tammy Kielian; Fiscal Year: 2007
    ..These experiments will provide meaningful insights into how proinflammatory mediators influence the extent of glial GJC in brain abscess. ..
  6. D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
    Eric Storch; Fiscal Year: 2007
    ..Such agents may have utility in improving outcome, reducing premature therapy termination, and targeting patients who have been treatment refractory. ..
  7. Genome-wide screening of E. coli for bacteremia
    Kwang Kim; Fiscal Year: 2007
    ..Further identification and characterization of microbial determinants contributing to E. coli bacteremia should help in development of preventive measures such as vaccines against E. coli bacteremia. ..
  8. E. coli invasion of brain endothelial cells
    Kwang Kim; Fiscal Year: 2007
    ..3.To determine the role of K1 capsule in E. coli trafficking in HBMEC. Further understanding and characterization of E. coli K1-HBMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
  9. Research Training in Pediatric Infectious Diseases
    Kwang Kim; Fiscal Year: 2007
    ..Based on our research program, resources, and track record, we request support for 2 postdoctoral training positions per year with a total of 6 postdoctoral positions (two each of first, second, and third year trainees). ..
  10. Receptors Involved in Microglial Responses to S. aureus
    Tammy Kielian; Fiscal Year: 2007
    ....
  11. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..Determine whether Vspl crosses the BBB in vivo. 2. Investigate whether Vspl enters BMEC. 3. Determine whether Vspl crosses BMEC barriers. 4. Identify the structural features that mediate the interaction of Vspl with BMEC. ..
  12. GP 120 MEDIATED ACTIVATION OF BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2002
    ..e., roles of G proteins and signaling pathways, platelet-activating factor (PAF). The information derived from this proposal should enhance our understanding of the role of HBMEC in HIV encephalopathy. ..
  13. E. COLI BINDING TO BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2003
    ....
  14. E COLI INVASION OF BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2003
    ..Further understanding and characterization of these E. coli K1-BMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
  15. Leukotrienes and blood-brain barrier
    Kwang S Kim; Fiscal Year: 2010
    ..We propose to determine the contribution of the host molecules involving leukotrienes to microbial traversal of the blood-brain barrier. ..