maduromycosis

Summary

Summary: A disease caused by various fungi (Madurella mycetomi) or actinomycetes (Nocardia brasiliensis). It usually affects the foot, hand, and legs with tissues becoming necrosed and swollen after infection.

Top Publications

  1. pmc Infection with Scedosporium apiospermum and S. prolificans, Australia
    Louise Cooley
    Alfred Hospital, Prahran, Victoria, Australia
    Emerg Infect Dis 13:1170-7. 2007
  2. ncbi Disseminated phaeohyphomycosis: review of an emerging mycosis
    Sanjay G Revankar
    Dallas Veterans Administration Medical Center and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75216, USA
    Clin Infect Dis 34:467-76. 2002
  3. ncbi Scedosporium infection in a tertiary care cancer center: a review of 25 cases from 1989-2006
    Gregory A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Heath, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 43:1580-4. 2006
  4. ncbi Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist
    Josep Guarro
    Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Spain
    Med Mycol 44:295-327. 2006
  5. ncbi Scedosporium species infections and treatments
    W J Steinbach
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    J Chemother 15:16-27. 2003
  6. pmc Scedosporium apiospermum soft tissue infection successfully treated with voriconazole: potential pitfalls in the transition from intravenous to oral therapy
    Joanna M Schaenman
    Department of Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Rm S 100, Stanford, CA 94305, USA
    J Clin Microbiol 43:973-7. 2005
  7. ncbi Disseminated Pseudallescheria boydii (Scedosporium apiospermum) infection in a renal transplant patient
    E L Campagnaro
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Transpl Infect Dis 4:207-11. 2002
  8. ncbi Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome
    Shahid Husain
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Clin Infect Dis 40:89-99. 2005
  9. pmc Genotyping study of Scedosporium apiospermum isolates from patients with cystic fibrosis
    Alain Defontaine
    Laboratoire de Biotechnologie, Unité de Biocatalyse, FRE CNRS 2230, Nantes, France
    J Clin Microbiol 40:2108-14. 2002
  10. pmc Molecular phylogeny of the Pseudallescheria boydii species complex: proposal of two new species
    Felix Gilgado
    Unitat de Microbiologia Facultat de Medicina i Ciencias de la Salut, Universitat Rovira i Virgili C Sant Llorenç 21, 43201 Reus, Tarragona, Spain
    J Clin Microbiol 43:4930-42. 2005

Research Grants

  1. QUALITY OF LIFE AND RELATIONSHIPS AFTER BMT
    John Wingard; Fiscal Year: 2001
  2. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008

Detail Information

Publications136 found, 100 shown here

  1. pmc Infection with Scedosporium apiospermum and S. prolificans, Australia
    Louise Cooley
    Alfred Hospital, Prahran, Victoria, Australia
    Emerg Infect Dis 13:1170-7. 2007
    ..Scedosporium spp. showed distinct clinical and epidemiologic features...
  2. ncbi Disseminated phaeohyphomycosis: review of an emerging mycosis
    Sanjay G Revankar
    Dallas Veterans Administration Medical Center and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75216, USA
    Clin Infect Dis 34:467-76. 2002
    ..The development of newer antifungal agents and combination therapy may hold promise in improving the management of these devastating infections in the future...
  3. ncbi Scedosporium infection in a tertiary care cancer center: a review of 25 cases from 1989-2006
    Gregory A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Heath, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 43:1580-4. 2006
    ..Cases of S. prolificans infection occurred only after 2000. Dissemination occurred in 16 patients (64%). The 12-week mortality rates were 70% and 100% for S. apiospermum and S. prolificans infection, respectively...
  4. ncbi Scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist
    Josep Guarro
    Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Spain
    Med Mycol 44:295-327. 2006
    ..The natural environmental habitat of the fungus is unknown; nutrient-rich, brackish waters like river estuaria have been suggested. The fungus is strongly promoted by agricultural and particularly by industrial pollution...
  5. ncbi Scedosporium species infections and treatments
    W J Steinbach
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    J Chemother 15:16-27. 2003
    ..Finally, we detail the available in vitro, animal model, and clinical data on the treatment of Scedosporium species infections with special emphasis on the role of newer antifungal therapies for these recalcitrant infections...
  6. pmc Scedosporium apiospermum soft tissue infection successfully treated with voriconazole: potential pitfalls in the transition from intravenous to oral therapy
    Joanna M Schaenman
    Department of Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Rm S 100, Stanford, CA 94305, USA
    J Clin Microbiol 43:973-7. 2005
    ..The potential usefulness of plasma voriconazole levels for guiding optimal therapy should be investigated...
  7. ncbi Disseminated Pseudallescheria boydii (Scedosporium apiospermum) infection in a renal transplant patient
    E L Campagnaro
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Transpl Infect Dis 4:207-11. 2002
    ..Despite treatment with multiple antifungal medications, the patient died of cardiac dysrhythmia. Current diagnostic and therapeutic alternatives for P. boydii are reviewed...
  8. ncbi Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome
    Shahid Husain
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Clin Infect Dis 40:89-99. 2005
    ..Unique characteristics, impact of therapy with antifungal agents, and outcome of infections with Scedosporium species were assessed in transplant recipients...
  9. pmc Genotyping study of Scedosporium apiospermum isolates from patients with cystic fibrosis
    Alain Defontaine
    Laboratoire de Biotechnologie, Unité de Biocatalyse, FRE CNRS 2230, Nantes, France
    J Clin Microbiol 40:2108-14. 2002
    ..Thus, our study demonstrates the persistence of the fungus despite antifungal treatments and therefore reinforces the need for the development of new antifungals that are more efficient against this species...
  10. pmc Molecular phylogeny of the Pseudallescheria boydii species complex: proposal of two new species
    Felix Gilgado
    Unitat de Microbiologia Facultat de Medicina i Ciencias de la Salut, Universitat Rovira i Virgili C Sant Llorenç 21, 43201 Reus, Tarragona, Spain
    J Clin Microbiol 43:4930-42. 2005
    ..minutispora are environmental. Further studies are needed to demonstrate whether all the species included in the P. boydii complex have different clinical spectra and antifungal susceptibility...
  11. ncbi Emerging moulds: Fusarium, Scedosporium and Zygomycetes in transplant recipients
    Marcio Nucci
    Department of Internal Medicine, University Hospital, Rio de Janeiro Federal University, Rio de Janeiro, Brazil
    Curr Opin Infect Dis 16:607-12. 2003
    ..This paper will review recent data regarding the epidemiology, clinical manifestations, treatment and the outcome of infections caused by Fusarium spp., Scedosporium spp. and the Zygomycetes in transplant recipients...
  12. ncbi Successful control of disseminated Scedosporium prolificans infection with a combination of voriconazole and terbinafine
    B P Howden
    Department of Infectious Diseases, The Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
    Eur J Clin Microbiol Infect Dis 22:111-3. 2003
    ..Antifungal synergy testing and combination therapy should be considered in cases of disseminated infection with Scedosporium prolificans...
  13. ncbi Comparison of the virulence of Scedosporium prolificans strains from different origins in a murine model
    M Ortoneda
    Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain
    J Med Microbiol 51:924-8. 2002
    ..No significant differences were found between the strains from different geographic areas or different forms of disease...
  14. ncbi Lung scedosporiosis: a differential diagnosis of aspergillosis
    Madjed Al Refaï
    Department of Thoracic and Cardio vascular Surgery, CHRU de Caen, Cote de Nacre, Caen, France
    Eur J Cardiothorac Surg 21:938-9. 2002
    ..However, it must be detected because of its frequent resistance to medical treatment. Two cases of pulmonary scedosporiosis that were surgically treated are reported herein...
  15. ncbi Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation
    M Reza Vagefi
    Department of Ophthalmology, University of California, San Francisco, California 94143 0730, USA
    Am J Ophthalmol 139:370-3. 2005
    ..To report a case of bilateral endogenous fungal endophthalmitis resulting from disseminated Scedosporium prolificans...
  16. ncbi Scedosporium apiospermum soft-tissue infection: a case report and review of kidney transplant literature
    C Farina
    Microbiology Institute, A O Ospedale San Carlos Borromeo, Milano, Italy
    Transplant Proc 38:1333-5. 2006
    ..We have reported here a case of a dramatic soft tissue infection by S. apiospermum in a kidney-transplanted man. Surgical drainage together with voriconazole systemic therapy was successful...
  17. ncbi Scedosporium prolificans: an uncommon cause of septic arthritis
    Philip A Dalton
    Department of Orthopaedic Surgery, The Ipswich General Hospital, Ipswich, Australia
    ANZ J Surg 76:661-3. 2006
    ..This fungus is resistant to most commonly prescribed antifungal agents. We report the successful treatment of Scedosporium prolificans septic arthritis with a combination of surgery and new antifungal agents...
  18. ncbi Two cases of subcutaneous Scedosporium apiospermum infection treated with voriconazole
    F Bosma
    Department of Medical Microbiology, University Medical Center Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Clin Microbiol Infect 9:750-3. 2003
    ..apiospermum, and random amplified polymorphic DNA (RAPD) fingerprinting showed that the patients' strains were genotypically unrelated, we considered a common nosocomial source of S. apiospermum to be unlikely...
  19. ncbi Scedosporium apiospermum mycetoma with bone involvement successfully treated with voriconazole
    L Porte
    Department of Infectious and Tropical Diseases, Purpan University Hospital, 31059 Toulouse Cedex, France
    Trans R Soc Trop Med Hyg 100:891-4. 2006
    ..As of July 2005, the patient remains clinically well. Voriconazole appears to be a promising drug for the treatment of S. apiospermum mycetomas...
  20. ncbi A novel murine model of cerebral scedosporiosis: lack of efficacy of amphotericin B
    Javier Capilla
    Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, 43201 Reus, Spain
    J Antimicrob Chemother 54:1092-5. 2004
    ....
  21. ncbi Disseminated Scedosporium prolificans infection and survival of a child with acute lymphoblastic leukemia
    Morag Whyte
    Department of Pediatric Oncology, Banksia Unit, Royal Children s Hospital, Herston, Brisbane, Queensland, Australia 4029
    Pediatr Infect Dis J 24:375-7. 2005
    ..prolificans sepsis after induction chemotherapy for acute lymphoblastic leukemia. She is well 18 months after the diagnosis of fungal sepsis and continues to receive chemotherapy for leukemia, which remains in remission...
  22. ncbi [Disseminated infections due to Scedosporium apiospermum in a patient with anaplastic large cell lymphoma. A case study]
    Maria Dan
    Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Medicina, Disciplina de Microbiologie Medicala, Spitalul Clinic de Urgenţe Sf Spiridon, Iasi
    Rev Med Chir Soc Med Nat Iasi 109:638-41. 2005
    ..Based on significant improvement of liver lesions with voriconazole therapy, we proposed the diagnostic "probable" disseminated infections due to S.apiospermum...
  23. ncbi Treatment of a chronic Scedosporium apiospermum vertebral osteomyelitis. Case report
    John W German
    Division of Neurosurgery, and College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA
    Neurosurg Focus 17:E9. 2004
    ..Application of these principles has led to an adequate 2-year outcome...
  24. ncbi Scedosporium apiospermum brain abscess treated with surgery and voriconazole. Case report
    Aabir Chakraborty
    Department of Neurosurgery, Kings College Hospital, Denmark Hill, London, United Kingdom
    J Neurosurg 103:83-7. 2005
    ..The authors review the use of voriconazole for central nervous system infections and review the literature on S. apiospermum associated with near drowning...
  25. ncbi Interaction of granulocyte colony-stimulating factor and high doses of liposomal amphotericin B in the treatment of systemic murine scedosporiosis
    Montserrat Ortoneda
    Unitat de Microbiologia, Facultat de Medicina i Cències de la Salut, Universitat Rovira i Virgili, Reus, Spain
    Diagn Microbiol Infect Dis 50:247-51. 2004
    ..5 mg/kg/day) and granulocyte colony-stimulating factor (G-CSF) (300 microg/kg/day) were ineffective. The combination of LAMB (40 mg/kg/day) and G-CSF (150 or 300 microg/kg/day) did not improve the results obtained with LAMB alone...
  26. ncbi Pseudoporphyria as a result of voriconazole use: a case report
    Christopher K Dolan
    United States Naval Reserve, Patuxent River Naval Medical Clinic, Patuxent River, MD, USA
    Int J Dermatol 43:768-71. 2004
    ..We present the case of a patient who developed pseudoporphyria after receiving treatment with voriconazole...
  27. pmc Antifungal activities of posaconazole and granulocyte-macrophage colony-stimulating factor ex vivo and in mice with disseminated infection due to Scedosporium prolificans
    M Simitsopoulou
    3rd Department of Pediatrics, Hippokration Hospital, 49 Konstantinoupoleos St, GR 546 42 Thessaloniki, Greece
    Antimicrob Agents Chemother 48:3801-5. 2004
    ..08 compared with the results for the controls). While the combination of POS and GM-CSF showed enhanced activity ex vivo, it did not increase the activities of the two agents against this highly refractory filamentous fungus in mice...
  28. ncbi Interferon-gamma and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children
    Mark J Abzug
    University of Colorado School of Medicine and The Children s Hospital Pediatric Infectious Diseases, Department of Pediatrics, Denver, CO 80218, USA
    Pediatr Infect Dis J 23:769-73. 2004
    ..Adjunctive therapy with interferon-gamma, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections...
  29. ncbi [Pseudoallescheria boydii (Scedosporium apiospermum), cause of mycotic granulomatous osteomyelitis--case diagnosis]
    Jelena Sopta
    Srp Arh Celok Lek 133:366-9. 2005
    ..The diagnostic procedure was repeated and mycetoma was confirmed once again. Surgery was again the therapy of choice, because Pseudoallescheria boydii is resistant to treatment with antimycotic drugs...
  30. ncbi Pseudoallescheria boydii pneumonia and empyema: a rare complication of heart transplantation cured with voriconazole
    Mark G Perlroth
    Division of Cardiovascular Disease, Department of of Medicine, Stanford University, Stanford, California 94305, USA
    J Heart Lung Transplant 23:647-9. 2004
    ..Pseudoallescheria boydii pneumonia is a rare occurrence, usually resistant to amphotericin B and other anti-fungal agents. We report a complete response to voriconazole in an immunosuppressed host...
  31. ncbi Pseudallescheria boydii releases metallopeptidases capable of cleaving several proteinaceous compounds
    Bianca A Silva
    Departamento de Microbiologia Geral, Instituto de Microbiologia Prof Paulo de Góes IMPPG, Centro de Ciencias da Saude CCS, Bloco I, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, RJ, Brazil
    Res Microbiol 157:425-32. 2006
    ..boydii capable of degrading several proteinaceous compounds that could help the fungus to escape from natural human barriers and defenses...
  32. ncbi New options for the treatment of invasive fungal infections
    Zachary A Rubin
    Department of Medicine, Emory University Division of Infectious Diseases, Atlanta, GA, USA
    Semin Oncol 31:91-8. 2004
    ..We review the clinical data, side effects, drug interactions, and unique spectrum of activity of these newer antifungal agents against both Candida and clinically relevant mold species...
  33. ncbi Lethal brain abscess due to the fungus Scedosporium apiospermum (teleomorph Pseudallescheria boydii) after a near-drowning incident: case report and review of the literature
    W Buzina
    Medical Mycology, Institute of Hygiene, Medical University Graz, Universitaetsplatz, Graz, Austria
    Med Mycol 44:473-7. 2006
    ..The patient died 153 days after the accident despite antifungal therapy. We discuss the role of antifungals and review the literature for comparable cases...
  34. ncbi [Case of Scedosporium apiospermum cutaneous soft tissue infection treated with voriconazole]
    Mitsuru Konishi
    Center for Infectious Diseases, Department of General Medicine, Nara Medical University
    Kansenshogaku Zasshi 82:82-5. 2008
    ..Because VRCZ-induced liver dysfunction was reported significantly associated with plasma level, we treated this case safely by administering VRCZ while measuring the plasma concentration...
  35. ncbi Scedosporium apiospermum (Pseudoallescheria boydii) infection in lung transplant recipients
    Hina Sahi
    Department of Pulmonary, Allergy, and Critical Care Medicine, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 26:350-6. 2007
    ..Infection is associated with a high rate of dissemination and poor outcome overall...
  36. ncbi Cutaneous Scedosporium apiospermum infection in an immunocompromised patient and a review of the literature
    Takeshi Uenotsuchi
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Acta Derm Venereol 85:156-9. 2005
    ..We also review the cases of S. apiospermum infection with cutaneous manifestations reported between 1998 and 2003...
  37. ncbi Activity of voriconazole against corneal isolates of Scedosporium apiospermum
    Kekul B Shah
    Sid W Richardson Ocular Microbiology Laboratory, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    Cornea 22:33-6. 2003
    ..To determine the in vitro antifungal activity of voriconazole, a new triazole, compared with other polyene and imidazole antifungal agents against corneal isolates of Scedosporium apiospermum...
  38. ncbi Intravitreal voriconazole for the treatment of endogenous endophthalmitis caused by Scedosporium apiospermum
    Fred K Chen
    Clin Experiment Ophthalmol 35:382-5. 2007
    ..Despite its efficacy in suppressing disseminated S. apiospermum infection, voriconazole may be ineffective in the treatment of endogenous S. apiospermum endophthalmitis especially if treatment is delayed...
  39. ncbi Multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient
    S Guignard
    Universite Rene Descartes, Hôpital Cochin APHP, Service de Rhumatologie B, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    J Cyst Fibros 7:89-91. 2008
    ..S. apiospermum osteoarticular infections are rare, and are difficult to diagnose and cure because of their resistance to anti-fungal drugs...
  40. ncbi Endobronchitis by Scedosporium apiospermum in a child with cystic fibrosis
    Oscar Vázquez-Tsuji
    Laboratorio de Biología Molecular y Microscopía Electrónica, Facultad Mexicana de Medicina, Universidad La Salle, Mexico
    Rev Iberoam Micol 23:245-8. 2006
    ..The patient was treated with amphotericin B and itraconazole...
  41. ncbi Breakthrough Scedosporium apiospermum (Pseudallescheria boydii) brain abscess during therapy for invasive pulmonary aspergillosis following high-risk allogeneic hematopoietic stem cell transplantation. Scedosporiasis and recent advances in antifungal ther
    A Safdar
    Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Transpl Infect Dis 4:212-7. 2002
    ....
  42. ncbi Breakthrough Scedosporium prolificans infection while receiving voriconazole prophylaxis in an allogeneic stem cell transplant recipient
    S Y C Tong
    Victorian Infectious Diseases Service, Department of Microbiology, Royal Melbourne Hospital, Melbourne, Australia
    Transpl Infect Dis 9:241-3. 2007
    ..S. prolificans is a life-threatening mold that should be considered in patients with breakthrough invasive fungal infections while on voriconazole prophylaxis...
  43. ncbi Multiple Scedosporium apiospermum brain abscesses after near-drowning successfully treated with surgery and long-term voriconazole: a case report
    M Leechawengwongs
    Mycoses 50:512-6. 2007
    ..Voriconazole appears to be the antifungal agent of choice in the treatment of CNS scedosporiosis caused by S. apiospermum...
  44. pmc Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits
    Javier Capilla
    Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain
    Antimicrob Agents Chemother 47:1948-51. 2003
    ..0001 versus control group), and only this dosage was able to reduce tissue burden significantly in the five organs studied, i.e., spleen, kidneys, liver, lungs, and brain...
  45. ncbi Intraspecific diversity of species of the Pseudallescheria boydii complex
    J S Zeng
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba, Japan
    Med Mycol 45:547-58. 2007
    ..Though we need more evidence to locate the 3 clades of the P. boydii complex at species or population level, the sequence of the D1/D2 region is sufficiently variable for identification of taxa belonging to the P. boydii complex...
  46. ncbi [Cutaneous and osteoarticular Scedosporium apiospermum infection]
    Ségolène Fays
    Service de Dermatologie, hôpital Beauregard, 21, rue des Frères, 57126 Thionville Cedex
    Ann Med Interne (Paris) 153:537-9. 2002
    ..This emergent fungal infection, which has non specific clinical manifestations, must be considered in immunocompromised patients...
  47. ncbi Atypical presentation of Madurella mycetomatis mycetoma in a renal transplant patient
    J F Meis
    Department of Medical Microbiology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Transpl Infect Dis 2:96-8. 2000
    ..There were no black grains in the pus and no overlying sinuses. This was an atypical presentation of maduromycosis in a renal transplant patient.
  48. ncbi [Actinomycetoma and Nocardia sp. Report of five cases treated with imipenem or imipenem plus amikacin]
    Adán Fuentes
    Departamento de Dermatologia, Hospital General Dr Manuel Gea González SSA, Mexico DF
    Gac Med Mex 142:247-52. 2006
    ..Imipenem has shown to be effective both in vitro and in vivo against some actinomycetes. Amikacin with Imipenem has a synergistic effect...
  49. pmc Nocardia mexicana sp. nov., a new pathogen isolated from human mycetomas
    Veronica Rodriguez-Nava
    UMR CNRS 5557, Center for Microbial Ecology, Observatoire Français des Nocardioses, Laboratoire de Mycologie Fondamentale et Appliquée aux Biotechnologies Industrielles, Faculte de Pharmacie, Universite Claude Bernard Lyon I, Lyon, France
    J Clin Microbiol 42:4530-5. 2004
    ..The data obtained indicated that the three clinical strains should be recognized as a new species for which the name Nocardia mexicana sp. nov. is proposed...
  50. ncbi Adenocarcinoma of the lung presenting as a mycetoma with an air crescent sign
    Lan Fu Wang
    Chest Department, Taipei Veterans General Hospital, 201 Section 2, Shih Pai Rd, Taipei 112, Taiwan, Republic of China
    Chest 131:1239-42. 2007
    ..Thus, even though the chest radiograph and chest CT scan showed a typical air-crescent sign (ie, mass inside a cavity) favoring a mycetoma, the physician should still keep in mind that lung cancer may also unusually present in this way...
  51. ncbi A successfully treated case of mycetoma due to Nocardia veterana
    M Kashima
    Department of Dermatology, St Marianna University, Kawasaki, Kanagawa 216 8511, Japan
    Br J Dermatol 152:1349-52. 2005
    ..This is the first case report of mycetoma due to N. veterana in a clinical setting...
  52. ncbi Disseminated Scedosporium apiospermum infection in renal transplant recipient: long-term successful treatment with voriconazole: a case report
    P G Rogasi
    Malattie Infettive, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Transplant Proc 39:2033-5. 2007
    ..The infection was successfully treated with voriconazole, but due to the severe iatrogenic immune suppression, a strong reduction in immunosuppressant drugs was needed...
  53. ncbi Periocular abscess caused by Pseudallescheria boydii after a posterior subtenon injection of triamcinolone acetonide
    In Kyung Oh
    Department of Ophthalmology, Anam Hospital, Korea University College of Medicine, 26 1 Anam dong 5 ga, Sungbuk Gu, Seoul, 136 705, South Korea
    Graefes Arch Clin Exp Ophthalmol 245:164-6. 2007
    ..Here, we report a case of periocular abscess following posterior subtenon injection of triamcinolone...
  54. ncbi Cure of orthopaedic infection with Scedosporium prolificans, using voriconazole plus terbinafine, without the need for radical surgery
    I B Gosbell
    Department of Microbiology and Infectious Diseases, South Western Area Pathology Service, Liverpool
    Mycoses 46:233-6. 2003
    ..prolificans, in which the combinations of itraconazole/terbinafine and voriconazole/terbinafine showed synergy in vitro, and success was achieved without radical surgery, using voriconazole and terbinafine...
  55. ncbi A case of mycetoma successfully treated with itraconazole and co-trimoxazole
    Kamer Gunduz
    Department of Dermatology, Celal Bayar University, No 25 5 Manisa, Turkey
    Mycoses 49:436-8. 2006
    ..i.d.) was added to treatment. Complete remission was established by MRI examination after 10 months with this combination therapy...
  56. ncbi An immunocompetent patient with primary Scedosporium apiospermum vertebral osteomyelitis
    Nicholas B Levine
    Department of Neurosurgery, Neuroscience Institute, University of Cincinnati College of Medicine, Ohio 45267 0515, USA
    J Spinal Disord Tech 15:425-30. 2002
    ..boydii spinal infections in two previously reported immunocompromised patients, although the optimal antifungal regimen for this infection has not been established...
  57. ncbi In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Antimicrob Chemother 59:553-5. 2007
    ..Eumycetoma caused by Madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required...
  58. ncbi Mycetoma : a review
    Vanessa Lichon
    University of Illinois, Chicago, Illinois, USA
    Am J Clin Dermatol 7:315-21. 2006
    ..Without proper treatment, mycetoma can lead to deformity, amputation, and death...
  59. ncbi Gauze-assisted technique in endoscopic removal of fungus balls of the maxillary sinus
    Ting Kuang Chao
    Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan
    Am J Rhinol 20:417-20. 2006
    ..The aim of this study was to establish and evaluate a newly developed gauze-assisted technique in complete removal of fungus balls of the maxillary sinus with usual instruments of endoscopic sinus surgery...
  60. ncbi Translationally controlled tumor protein from Madurella mycetomatis, a marker for tumorous mycetoma progression
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Immunol 177:1997-2005. 2006
    ..After 6-15 years of disease duration the Ab levels were the highest. TCTP is the first well-characterized immunogenic Ag, simultaneously the first monomolecular vaccine candidate, identified for the fungus M. mycetomatis...
  61. ncbi [Case of pulmonary pseudallescheriasis responding successfully to treatment with voriconazole]
    Yoshikazu Awaya
    Department of Medicine, Miyoshi Central Hospital
    Nihon Kokyuki Gakkai Zasshi 45:788-92. 2007
    ..We performed a left upper lobectomy, because residual the shadows were recognized on chest CT. Here we report a rare case of pulmonary pseudallescheriasis successfully treated with voriconazole and left upper lobectomy...
  62. ncbi Fungus balls of the paranasal sinuses: a review
    Pierre Grosjean
    Service d ORL et de Chirurgie Cervico faciale, Lausanne, Switzerland
    Eur Arch Otorhinolaryngol 264:461-70. 2007
    ..In this paper, we review the clinical, radiological, and pathological presentation of the fungus ball of the paranasal sinuses as well as the surgical management with emphasis on the transnasal endoscopic approach...
  63. ncbi [Maxillary sinus infection with emphysema of the head as a "red herring" in steroid associated colon perforation]
    P Frei
    Medizinische Klinik, Spital Zollikerberg, Zollikerberg
    Ther Umsch 63:763-6. 2006
    ..In this report we present a case of chronic steroid use, where asymptomatic sigma perforation led to a generalized emphysema, which was initially attributed to a maxillary sinus infection due to Aspergillus and anaerobic bacteria...
  64. ncbi A rare European case of Madura Foot due to actinomycetes
    Luigi de Palma
    Cattedra di Ortopedia e Traumatologia, Universita Politecnica delle Marche, Ancona, Ospedali Riuniti Umberto, Italy
    Joint Bone Spine 73:321-4. 2006
    ..The patient has been able to resume ambulation with normal footwear. Given the absence of liver and kidney functional alterations, the patient is scheduled to continue pharmacological treatment with trimethoprim-sulfamethoxazole...
  65. ncbi Cerebral scedosporiosis: an emerging fungal infection in severe neutropenic patients: CT features and CT pathologic correlation
    Enrique Marco de Lucas
    Department of Radiology, Hospital Universitario Marques de Valdecilla, Av Valdecilla s n, 39008, Santander, Cantabria, Spain
    Eur Radiol 16:496-502. 2006
    ..Thus, Scedosporium can be included as a rare but possible cause of invasive fungal disseminated central nervous system infections in severely neutropenic patients...
  66. ncbi Reclassification of Amycolatopsis orientalis DSM 43387 as Amycolatopsis benzoatilytica sp. nov
    Swati Majumdar
    Molecular Biology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007, India
    Int J Syst Evol Microbiol 56:199-204. 2006
    ..nov. is proposed for strain DSM 43387 that was previously classified as Amycolatopsis orientalis. The type strain is AK 16/65T (= DSM 43387T = ATCC 55165T = IMRU 1389T)...
  67. pmc Caspofungin and liposomal amphotericin B therapy of experimental murine scedosporiosis
    Rosie Bocanegra
    The University of Texas Health Science Center at San Antonio, Department of Medicine Division of Infectious Diseases MC 7881, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 49:5139-41. 2005
    ..Amphotericin B and caspofungin were each effective, but combined therapy did not appear to offer advantages over liposomal amphotericin B alone...
  68. ncbi Central nervous system pseudallescheriasis after near-drowning
    Kessarin Panichpisal
    Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA
    Clin Neurol Neurosurg 108:348-52. 2006
    ..Clinical characteristics of central nervous system (CNS) pseudallescheriasis after near-drowning have not been systematically analyzed...
  69. ncbi Lymphocyte subsets, macrophages and Langerhans cells in actinomycetoma and eumycetoma tissue reaction
    Claudia Cenci Guimarães
    Department of Pathology, University of Sao Paulo Medical School, Av Dr Arnaldo, 455 sala 1118, 01246 903 Sao Paulo, SP, Brazil
    Acta Trop 87:377-84. 2003
    ..The morphological alterations and marked reduction of LC in mycetoma lesions might reflect a depressed cellular immune response, partially explaining the chronic course and unresponsiveness to treatment of this group of diseases...
  70. ncbi Case report: Nocardia asteroides mycetoma
    Christopher A Lum
    Department of Pathology, LAC USC Medical Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Ann Clin Lab Sci 33:329-33. 2003
    ....
  71. ncbi Phylogeny and typification of Madurella mycetomatis, with a comparison of other agents of eumycetoma
    G S de Hoog
    Centraalbureau voor Schimmeccultures, Utrecht, The Netherlands
    Mycoses 47:121-30. 2004
    ..Judging from ITS data, M. mycetomatis and N. rosatii are species complexes. The ex-type strain of N. rosatii, from a human mycetome, has an ITS sequence that deviates from that of environmental strains of the species...
  72. ncbi Mycetoma: a thorn in the flesh
    A H Fahal
    Faculty of Medicine, Mycetoma Research Centre, University of Khartoum, PO Box 102, Khartoum, Sudan
    Trans R Soc Trop Med Hyg 98:3-11. 2004
    ..Actinomycetoma is amenable to treatment by antibiotics, preferably by combined drug therapy for long periods. Eumycetoma is usually treated by aggressive surgical excision combined with medical treatment...
  73. ncbi [Mycetomas in central Tunisia]
    M Denguezli
    Service de Dermatologie, CHU Farhat Hached, 4002 Sousse, Tunisie
    Ann Dermatol Venereol 130:515-8. 2003
    ..Mycetomas are inflammatory pseudo-tumors containing fungal or actinomycosic-type grains. They are frequent in tropical and subtropical countries and unknown in Tunisia...
  74. ncbi Primary renal candidiasis: fungal mycetomas in the kidney
    Burzin S Morris
    Department of Radiology, Seth GS Medical College, KEM Hospital, Mumbai, India
    Australas Radiol 46:57-9. 2002
    ..Fortuitously, spontaneous passage of fungal particulate matter in urine was later reported...
  75. pmc Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays
    Gloria M Gonzalez
    Division of Infectious Diseases 7881, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Antimicrob Agents Chemother 47:1436-8. 2003
    ..Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues...
  76. ncbi External beam radiotherapy: a treatment option for massive haemoptysis caused by mycetoma
    Conrad Falkson
    Department of Radiation Oncology, Johannesburg Hospital, University of Witwatersrand, South Africa
    Clin Oncol (R Coll Radiol) 14:233-5. 2002
    ..Radiation therapy is an effective modality of treatment for life-threatening haemoptysis due to a mycetoma with no significant acute or late side effects...
  77. ncbi MRI of mycetoma of the foot: two cases demonstrating the dot-in-circle sign
    I Sarris
    Medical School, University of Oxford, Oxford, UK
    Skeletal Radiol 32:179-83. 2003
    ..This "dot-in-circle sign" on MRI reflects the unique pathological features of mycetoma and is likely to be a highly specific sign for this lesion...
  78. pmc Madurella mycetomatis strains from mycetoma lesions in Sudanese patients are clonal
    Abdalla Ahmed
    Mycetoma Research Group, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
    J Clin Microbiol 41:4537-41. 2003
    ..mycetomatis strains from Sudan. The data tentatively imply that different manifestations of mycetoma are due to differences in host susceptibility rather than differential virulence of the causative agent...
  79. pmc Eumycetoma caused by Cladophialophora bantiana in a dog
    J Guillot
    Service de Parasitologie Mycologie, UMR BIPAR, Ecole Nationale Veterinaire d Alfort, Maisons Alfort, France
    J Clin Microbiol 42:4901-3. 2004
    ..This is, to the best of our knowledge, the first case in which C. bantiana is identified as the causative agent of eumycetoma...
  80. ncbi Mycetoma of the hand
    R E Martinez
    Department of Plastic Surgery, Tulane University School of Medicine, New Orleans, LA 70124
    J Hand Surg Am 14:909-12. 1989
    Mycetoma or maduromycosis is a rare chronic granulomatous disease caused by a fungus infection...
  81. ncbi [Immunoglobulins in patients with Nocardia brasiliensis actinomycetoma]
    L J Mendez-Tovar
    Unidad de Investigación Médica en Dermatología y Micología, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS
    Rev Argent Microbiol 36:174-8. 2004
    ..As it occurs in other infections, in the actinomycetoma pathogenesis probably participate the increase or deficiency of a determined immunoglobulin class, as well as the relationship between different subclasses...
  82. pmc Infection of the CNS by Scedosporium apiospermum after near drowning. Report of a fatal case and analysis of its confounding factors
    P A Kowacs
    Division of Neurology, Internal Medicine Department, Hospital de Clinicas da Universidade Federal do Parana, 80060 900 Curitiba, Brazil
    J Clin Pathol 57:205-7. 2004
    ..Physicians should be aware of this condition, and provide prompt stereotactic biopsy. Confirmed cases should perhaps be treated with voriconazole, probably the most effective, currently available treatment for this agent...
  83. ncbi Madurella mycetomatis as an agent of brain abscess: case report and review of literature
    Fatima Mir
    Departmnet of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan
    Mycopathologia 176:429-34. 2013
    ..We found contiguous head and neck infections to be the principal cause of cerebral maduromycosis caused by M. mycetomatis. Early recognition of Madurella spp...
  84. ncbi Rapid formation of Aspergillus mycetoma in a patient receiving corticosteroid treatment. Serial radiographic observation over two months
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Shimotsuke
    Intern Med 46:733-7. 2007
    ..The rapid development of pulmonary aspergillosis associated with the formation of an Aspergillus mycetoma should be attributed to the loss of normal immune mechanisms due to immunosuppressive treatment...
  85. ncbi Mycetoma of the sole
    Ashok Menon Pulikot
    Department of Pediatrics, Sassoon General Hospitals, Poona, India
    Ann Trop Paediatr 22:187-90. 2002
    ..We report a case of mycetoma of the sole of the foot in a 10-year-old caused by Nocardia brasiliensis. It was treated successfully with a combination of trimethoprim-sulfamethoxazole, dapsone and rifampicin...
  86. ncbi Anterior chamber exudative mass due to Scedosporium apiospermum in an immunocompetent individual
    Sandeep Shankar
    Medical and Vision Research Foundations, Sankara Nethralaya, College Road, Chennai, India
    Indian J Ophthalmol 55:226-7. 2007
    ..We report here a case of an anterior chamber exudative mass due to S. apiospermum in an immunocompetent individual which was managed successfully with anterior chamber wash and intravitreal injection of voriconazole...
  87. ncbi Eumycetoma presenting as a cerebellopontine angle mass lesion
    Narayanam Anantha Sai Kiran
    Department of Neurosurgery, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Clin Neurol Neurosurg 109:516-9. 2007
    ..The prognosis of this bizarre pathology is dismal despite all treatment modalities as compared to the usual tumors of the cerebellopontine angle that generally have a favorable outcome...
  88. ncbi Successful control of Scedosporium prolificans septic arthritis and probable osteomyelitis without radical surgery in a long-term renal transplant recipient
    J Y Z Li
    Department of Nephrology and Transplantation Services, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Transpl Infect Dis 10:63-5. 2008
    ..We also review the clinical presentation, treatment, and outcome of S. prolificans infection in patients with solid organ transplantation...
  89. ncbi Fungal keratitis caused by Scedosporium apiospermum: report of two cases and review of treatment
    Ziqiang Wu
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA
    Cornea 21:519-23. 2002
    ..We report our experience in treating two cases of Scedosporium apiospermum keratitis and provide a review of basic scientific and clinical data regarding the treatment of this visually devastating disease...
  90. ncbi Case Reports. Infection due to Scedosporium apiospermum in renal transplant recipients: a report of two cases and literature review of central nervous system and cutaneous infections by Pseudallescheria boydii/Sc. apiospermum
    M Montejo
    Mycoses 45:418-27. 2002
    ..apiospermum is given...
  91. ncbi Scedosporium apiospermum post-traumatic cranial infection
    Claudio Farina
    Microbiology Institute, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy
    Brain Inj 16:627-31. 2002
    ..This report is the case of a severe post traumatic infection by S. apiospermum in an immunocompetent young man. Surgical drainage associated with systemic therapy was successful...
  92. ncbi Bacterial pseudomycetoma in dwarf hamster, Phodopus sungorus
    Jaime Martorell
    Department of Animal Medicine and Surgery, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Dermatol 17:449-52. 2006
    ..To the authors' knowledge this is the first reported case of bacterial pseudomycetoma in a dwarf hamster...
  93. ncbi Treatment of Scedosporium apiospermum brain abscesses with posaconazole
    Ingo K Mellinghoff
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA, 90095, USA
    Clin Infect Dis 34:1648-50. 2002
    ..The infection progressed despite neurosurgical drainage and treatment with itraconazole, amphotericin B, and ketoconazole, but the brain abscesses completely resolved after treatment with posaconazole alone...
  94. ncbi Imaging diagnosis--sublumbar pseudomycetoma in a Persian cat
    Skye W Stanley
    Fifth Avenue Veterinary Specialists, 1 West 15th Street, New York, NY 10011, USA
    Vet Radiol Ultrasound 49:176-8. 2008
    ..A pseudomycetoma should be included in the differential diagnosis for an abdominal mass in a Persian cat, especially is accompanied by the sonographic findings noted above...
  95. pmc Infections caused by Scedosporium spp
    Karoll J Cortez
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Microbiol Rev 21:157-97. 2008
    ..By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans...
  96. ncbi Virulence studies of Scedosporium and Fusarium species in Drosophila melanogaster
    Gregory A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Infect Dis 196:1860-4. 2007
    ..Voriconazole mixed in fly food significantly protected flies infected with F. moniliforme or S. apiospermum but not those infected with S. prolificans...
  97. ncbi Scedosporiosis in patients with acute leukemia: a retrospective multicenter report
    Morena Caira
    Istituto di Ematologia, Universita Cattolica del Sacro Cuore, Largo Francesco Vito, I 00168 Rome, Italy
    Haematologica 93:104-10. 2008
    ..New drugs with in vitro activity against Scedosporium spp (voriconazole, posaconazole) should be considered. However, their clinical activity should be more widely demonstrated...
  98. ncbi Terbinafine: broad new spectrum of indications in several subcutaneous and systemic and parasitic diseases
    A Perez
    Novartis Pharma AG, Basel, Switzerland
    Mycoses 42:111-4. 1999
    ..Patients with chromoblastomycosis, and other mycoses (phaeohyphomycosis, maduromycosis, and mucormycosis) have also been successfully treated with terbinafine...
  99. ncbi Intracavitary hematoma simulating mycetoma formation
    Mark T Knower
    Section on Pulmonary and Critical Care, The Wake Forest University School of Medicine, Winston Salem, NC 27157 1054, USA
    J Thorac Imaging 17:84-8. 2002
    ..Familiarity with these radiographic "mimickers" of mycetoma will aid in avoiding misdiagnosis and unnecessary or improper invasive interventions when the appropriate clinical history and course of disease are appreciated...
  100. ncbi Scedosporium apiospermum traumatic endophthalmitis successfully treated with voriconazole
    Andrea Zarkovic
    Department of Ophthalmology, Waikato Hospital, Hamilton, New Zealand
    Int Ophthalmol 27:391-4. 2007
    ..A brief overview of voriconazole use for treatment of ocular infections is presented, and a comparison is made with antifungal agents traditionally used in ophathalmology...
  101. ncbi Mycetoma fungal infection: multiple organisms as colonizers or pathogens?
    Florian H Pilsczek
    Division of Infectious Disease, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Rev Soc Bras Med Trop 40:463-5. 2007
    ..Criteria for the diagnosis of the organisms, differentiation between colonizer and pathogen, and significance of mixed infections are discussed...

Research Grants2

  1. QUALITY OF LIFE AND RELATIONSHIPS AFTER BMT
    John Wingard; Fiscal Year: 2001
    ..This information is essential to subsequent planning and implementation of relevant, well-aimed interventions to minimize psychosocial disruption and enhance growth in future BMT recipients and their loved ones. ..
  2. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..