lupus

Summary

Summary: A form of cutaneous tuberculosis. It is seen predominantly in women and typically involves the nasal, buccal, and conjunctival mucosa.

Top Publications

  1. pmc Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    Emily C Baechler
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:2610-5. 2003
  2. pmc Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells
    Manar Kalaaji
    Department of Biochemistry, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    Am J Pathol 168:1779-92. 2006
  3. ncbi Drug-induced lupus
    Robert L Rubin
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Toxicology 209:135-47. 2005
  4. ncbi Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting
    Sonali Narain
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, Program in Epidemiology and Public Health, and Department of Biostatistics, University of Florida, Gainesville, USA
    Arch Intern Med 164:2435-41. 2004
  5. pmc A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta
    Amir Sharabi
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 103:8810-5. 2006
  6. ncbi Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition
    Benjamin A Garcia
    Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA
    J Proteome Res 4:2032-42. 2005
  7. ncbi Drug-induced lupus associated with synthetic conjugated estrogens
    Dana G Carroll
    Department of Pharmacy Practice, Harrison School of Pharmacy, Auburn University, Tuscaloosa, AL, USA
    Ann Pharmacother 41:702-6. 2007
  8. ncbi The regulation and activation of lupus-associated B cells
    Michele L Fields
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Immunol Rev 204:165-83. 2005
  9. ncbi Toll-like receptor 9 signaling protects against murine lupus
    Xiaobo Wu
    Washington University School of Medicine, St Louis, Missouri, USA
    Arthritis Rheum 54:336-42. 2006
  10. ncbi Lupus vulgaris: report of two cases
    Anna Wozniacka
    Department of Dermatology, Medical University of Lodz, Poland
    Int J Dermatol 44:299-301. 2005

Research Grants

  1. Treatment of SLE with N-acetylcysteine
    Andras Perl; Fiscal Year: 2010
  2. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
  3. Clinical Component
    BRIAN KOTZIN; Fiscal Year: 2003
  4. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
  5. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2004
  6. ANTIBODIES WITH PROTHROMBINASE ACTIVITY IN LUPUS
    Perumal Thiagarajan; Fiscal Year: 2003
  7. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2009
  8. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2009
  9. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
  10. Genetic and Immunological Impact of the HRES-1/Rab4 Locus in SLE
    Andras Perl; Fiscal Year: 2010

Detail Information

Publications172 found, 100 shown here

  1. pmc Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    Emily C Baechler
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:2610-5. 2003
    Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that affects multiple organ systems...
  2. pmc Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells
    Manar Kalaaji
    Department of Biochemistry, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    Am J Pathol 168:1779-92. 2006
    Antibodies to dsDNA represent a classification criterion for systemic lupus erythematosus. Subpopulations of these antibodies are involved in lupus nephritis...
  3. ncbi Drug-induced lupus
    Robert L Rubin
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Toxicology 209:135-47. 2005
    ..Drug-induced lupus has been reported as a side-effect of long-term therapy with over 40 medications...
  4. ncbi Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting
    Sonali Narain
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, Program in Epidemiology and Public Health, and Department of Biostatistics, University of Florida, Gainesville, USA
    Arch Intern Med 164:2435-41. 2004
    ..Since misdiagnosis of systemic autoimmune diseases can have serious consequences, we evaluated community physicians' accuracy in diagnosing autoimmune diseases and the consequences of misdiagnosis...
  5. pmc A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta
    Amir Sharabi
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 103:8810-5. 2006
    Systemic lupus erythematosus is an autoimmune disease characterized by autoantibodies and systemic clinical manifestations...
  6. ncbi Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition
    Benjamin A Garcia
    Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA
    J Proteome Res 4:2032-42. 2005
    The baseline level of gene expression varies between healthy controls and systemic lupus erythematosus (SLE) patients, and among SLE patients themselves...
  7. ncbi Drug-induced lupus associated with synthetic conjugated estrogens
    Dana G Carroll
    Department of Pharmacy Practice, Harrison School of Pharmacy, Auburn University, Tuscaloosa, AL, USA
    Ann Pharmacother 41:702-6. 2007
    To report a case of drug-induced lupus (DIL) in a patient taking Cenestin, a combination product of synthetic conjugated estrogens.
  8. ncbi The regulation and activation of lupus-associated B cells
    Michele L Fields
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Immunol Rev 204:165-83. 2005
    ..Additional studies are aimed at investigating the mechanisms of this suppression as well as probing the impact of distinct forms of T-cell-dependent and -independent activation on anti-dsDNA B cells...
  9. ncbi Toll-like receptor 9 signaling protects against murine lupus
    Xiaobo Wu
    Washington University School of Medicine, St Louis, Missouri, USA
    Arthritis Rheum 54:336-42. 2006
    ..9 (TLR-9), has been strongly implicated in the pathogenesis of autoantibody-mediated diseases such as systemic lupus erythematosus...
  10. ncbi Lupus vulgaris: report of two cases
    Anna Wozniacka
    Department of Dermatology, Medical University of Lodz, Poland
    Int J Dermatol 44:299-301. 2005
    ..b>Lupus vulgaris has been and remains the most common form of cutaneous tuberculosis...
  11. ncbi How Finsen's light cured lupus vulgaris
    Kirsten Iversen Møller
    Department of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen University, Copenhagen, Denmark
    Photodermatol Photoimmunol Photomed 21:118-24. 2005
    In 1903, Niels Ryberg Finsen was awarded the Nobel Prize for his invention of light therapy for skin tuberculosis (lupus vulgaris)...
  12. ncbi Adult lupus-prone MRL/MpJ2+ mice express a primary antibody repertoire that differs in CDR-H3 length distribution and hydrophobicity from that expressed in the C3H parental strain
    Michael Zemlin
    Clinic for Neonatology and Neuropediatrics, Philipps Universitat Marburg, Deutschhausstr 12, 35037 Marburg, Germany
    Mol Immunol 42:789-98. 2005
    ..evidence that when compared to C3H, a MRL/MpJ(2+) parental strain, CDR-H3 intervals from pre-B cells of adult lupus-prone MRL/MpJ(2+) mice are longer on average and are enriched for charged amino acids...
  13. ncbi Lupus arthropathy: a case series of patients with rhupus
    Andres Fernandez
    Department of Internal Medicine, Rheumatology Unit, Universidad Nacional de Colombia, Bogota, Colombia
    Clin Rheumatol 25:164-7. 2006
    Among the clinical manifestations of systemic lupus erythematosus (SLE) is an arthropathy, which is usually nonerosive. In many cases the joint involvement is mild...
  14. ncbi Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice
    Yoshiki Kuroda
    Division of Rheumatology and Clinical Immunology, Department of Medicine, ARB R2 156, 1600 SW Archer Road, Box 100221, Gainesville, FL 32610 0221, USA
    Toxicology 218:186-96. 2006
    ..adjuvant (IFA), or the adjuvant oil squalene, but not high molecular weight medicinal mineral oils, induces lupus-related autoantibodies to nRNP/Sm and -Su in non-autoimmune strains of mice...
  15. ncbi A case of lupus vulgaris with unusual location
    Mustafa Senol
    Inonu University Medical School, Department of Dermatology, Malatya, Turkey
    J Dermatol 30:566-9. 2003
    ..Here, we present a case of long-standing and atypically-located lupus vulgaris in an old man. The patient was successfully treated with triple antituberculous therapy.
  16. ncbi Lupus vulgaris: unusual presentations over the face
    S Khandpur
    Department of Dermatology and S T D, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India
    J Eur Acad Dermatol Venereol 17:706-10. 2003
    b>Lupus vulgaris (LV) is the most common morphological variant of cutaneous tuberculosis...
  17. ncbi Delayed diagnosis in a case of lupus vulgaris with unusual localization
    Can Ceylan
    Ege University Medical Faculty, Department of Dermatology, Bornova, Izmir, Turkey
    J Dermatol 31:56-9. 2004
    b>Lupus vulgaris is the most common form of cutaneous tuberculosis, and the usual sites of involvement are the head and neck...
  18. ncbi Long-term followup of children with neonatal lupus and their unaffected siblings
    Victor Martin
    Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 46:2377-83. 2002
    To determine in a longitudinal cohort study whether children with varied manifestations of neonatal lupus or their unaffected siblings later develop autoantibodies and/or rheumatic diseases.
  19. ncbi Effects of energy restriction and fish oil supplementation on renal guanidino levels and antioxidant defences in aged lupus-prone B/W mice
    You Jung Kim
    Department of Cosmetology, Pusan Women s College, Pusanjin gu, Pusan, Korea
    Br J Nutr 93:835-44. 2005
    ..ER) and dietary fish oil (FO) are known to reduce the severity of glomerulonephritis and increase the lifespan of lupus-prone (NZB x NZW) F1 (B/W) mice...
  20. ncbi Recurrent congenital heart block in neonatal lupus
    Maria C Escobar
    Pediatric Cardiology Unit, Hospital Vall d Hebron, Barcelona, Spain
    Clin Rheumatol 26:1161-3. 2007
    Congenital heart block (CHB) is the main complication of neonatal lupus (NL) and is strongly associated with the presence of anti-SSA/Ro and anti-SSB/La antibodies...
  21. pmc Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus
    Defu Zeng
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 112:1211-22. 2003
    ..levels of IgE, increased levels of IgG2a and IgG2a anti-double-stranded DNA (anti-dsDNA) Ab's, and exacerbated lupus. Conversely, treatment of NZB/W mice with blocking anti-CD1d mAb augmented Th2-type responses, increased serum ..
  22. pmc Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus
    Marta E Alarcon-Riquelme
    Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden
    Arthritis Res Ther 6:169-73. 2004
    Recent studies investigating the genetic susceptibility of systemic lupus erythematosus, rheumatoid arthritis and psoriasis have revealed a potential role for the RUNX proteins in the development of autoimmune disease...
  23. ncbi [Squamous cell carcinoma in lupus vulgaris]
    Jens Kimmritz
    Klinik für Dermatologie und Phlebologie, Vivantes Klinikum Prenzlauer Berg, Berlin
    J Dtsch Dermatol Ges 2:116-9. 2004
    b>Lupus vulgaris and carcinoma in lupo have become rare events that take place in the developed countries only under special circumstances. A 53-year-old woman developed such a carcinoma...
  24. ncbi Decreased T cell ERK pathway signaling may contribute to the development of lupus through effects on DNA methylation and gene expression
    Kurt Oelke
    Department of Medicine, University of Michigan, and the Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan
    Int Rev Immunol 23:315-31. 2004
    T cells from patients with active lupus have multiple biochemical abnormalities. One of these is DNA hypomethylation, which in model systems alters gene expression and induces lupus-like autoimmunity...
  25. ncbi A case of lupus vulgaris successfully treated with antituberculous therapy despite negative PCR and culture
    Gulsen Akoglu
    Department of Dermatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Dermatology 211:290-2. 2005
    ..Although the tuberculosis culture and PCR did not confirm tuberculosis, a diagnosis of lupus vulgaris was made considering the clinical and histopathological findings...
  26. pmc Low-dose exposure to inorganic mercury accelerates disease and mortality in acquired murine lupus
    Charles S Via
    Research Service, Department of Veteran Affairs Medical Center, Baltimore, Maryland, USA
    Environ Health Perspect 111:1273-7. 2003
    ..can alter the course of subsequent acquired autoimmune disease, we used a murine model of acquired autoimmunity, lupus-like chronic graft-versus-host disease (GVHD), in which autoimmunity is induced using normal, nonautoimmune prone ..
  27. ncbi Rapidly developing giant sized lupus vulgaris on the chest associated with bilateral scrofuloderma on the neck
    Cihangir Aliagaoglu
    Department of Dermatology, Numune State Hospital, Turkey
    J Dermatol 33:481-5. 2006
    b>Lupus vulgaris and scrofuloderma are the opposite poles of cutaneous tuberculosis. Lupus vulgaris of a giant size and scrofuloderma in the vicinity of this lesion were both present in a 70-year-old female patient...
  28. pmc Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus
    Lucrezia Colonna
    Laboratory of Dendritic Cell Biology, Division of Rheumatology, Joseph Stokes Jr, Research Institute, Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Arthritis Res Ther 8:R49. 2006
    We analyzed the activation and function of dendritic cells (DCs) in the spleens of diseased, lupus-prone NZM2410 and NZB-W/F1 mice and age-matched BALB/c and C57BL/6 control mice...
  29. pmc Effect of bisphenol A on murine immune function: modulation of interferon-gamma, IgG2a, and disease symptoms in NZB X NZW F1 mice
    Catherine Sawai
    Department of Biology, Carleton College, Northfield, Minnesota 55057, USA
    Environ Health Perspect 111:1883-7. 2003
    ..5 micro g BPA/kg body weight/day to both normal C57BL/6 and lupus-prone NZB X NZW F(1) (NZB/NZW) 5-week-old mice for 1 week...
  30. ncbi [Squamous epithelial carcinoma as a complication of lupus vulgaris]
    R Betti
    Clinica Dermatologica IV, Universita degli Studi di Milano, Ospedale San Paolo, Milano
    Hautarzt 53:118-20. 2002
    b>Lupus vulgaris represents a type of cutaneous tuberculosis that, if not correctly treated, presents a progressive chronic development whose long-term complications include cutaneous neoplasms...
  31. pmc Antibody induction of lupus-like neuropsychiatric manifestations
    David A Lawrence
    Wadsworth Center, Albany, NY 12201 0509, United States
    J Neuroimmunol 182:185-94. 2007
    Although systemic lupus erythematosus (SLE) is usually evaluated with regard to autoimmune reactivity toward the kidney, there are multiple psychiatric abnormalities associated with this autoimmune disease...
  32. ncbi T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens
    Syamal K Datta
    Department of Medicine, Feinberg School of Medicine, Northwestern University, 240 East Huron St, Chicago, IL 60611, USA
    J Mol Med (Berl) 83:267-78. 2005
    Special populations of T helper cells drive B cells to produce IgG class switched, pathogenic autoantibodies in lupus. The major source of antigenic determinants (epitopes) that trigger interactions between lupus T and B cells is ..
  33. ncbi Neonatal lupus syndromes
    J P Buyon
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA
    Lupus 13:705-12. 2004
    The neonatal lupus syndromes (NLS), while quite rare, carry significant mortality and morbidity in cases of cardiac manifestations...
  34. pmc A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen
    Dahai Xue
    Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 100:7503-8. 2003
    ..against a conserved RNA-binding protein, the Ro 60-kDa autoantigen, occur in 24-60% of all patients with systemic lupus erythematosus...
  35. pmc Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
    Petar S Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Arthritis Res Ther 8:203. 2006
    This review focuses on the role of Toll-like receptors (TLRs) in lupus and on possibilities to treat lupus using TLR modulating inhibitory oligodeoxynucleotides (INH-ODNs)...
  36. ncbi Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis
    Jessy J Alexander
    Section of Nephrology, Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 175:8312-9. 2005
    The role of complement activation in the brains of MRL/lpr lupus mice was determined using the potent C3 convertase inhibitor, CR1-related y (Crry), administered both as an overexpressing Crry transgene and as Crry-Ig...
  37. ncbi Neonatal lupus syndromes
    Jill P Buyon
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Rheumatol 15:535-41. 2003
    The neonatal lupus syndromes, although quite rare, provide an excellent opportunity to examine disease from bench to bedside. During the past year numerous publications have reported basic and clinical research...
  38. ncbi Association between nuclear antigens and endogenous retrovirus in the generation of autoantibody responses in murine lupus
    Rebecca M Tucker
    University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, Colorado
    Arthritis Rheum 50:3626-36. 2004
    NZB x NZW)F(1) (NZB/NZW) mice and other strains of mice with experimental lupus frequently produce autoantibodies to both chromatin constituents and murine leukemia virus envelope gp70...
  39. ncbi Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice
    J D Mountz
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, AL 35294, USA
    Scand J Immunol 61:128-38. 2005
    ..The features of lupus and arthritis developed by the BXD2 mice segregate in F2 mice generated by crossing BXD2 mice with the parental B6 ..
  40. ncbi Lupus vulgaris--report of a case with facial involvement
    S Thomas
    Department of Oral Medicine and Radiology, College of Dental Surgery, Manipal 57604, Karnataka, India
    Br Dent J 198:135-7. 2005
    ..In this report we discuss a case of lupus vulgaris with emphasis on the diagnostic approach to be followed by dental practitioners who come across a similar ..
  41. ncbi Dissociation of the genetic loci leading to b1a and NKT cell expansions from autoantibody production and renal disease in B6 mice with an introgressed New Zealand Black chromosome 4 interval
    Christina Loh
    Arthritis Centre of Excellence, Toronto Western Research Institute, Toronto, Ontario, Canada
    J Immunol 178:1608-17. 2007
    Previous mapping studies have linked New Zealand Black (NZB) chromosome 4 to several lupus traits, including autoantibody production, splenomegaly, and glomerulonephritis...
  42. ncbi Lupus vulgaris developing at the site of misdiagnosed scrofuloderma
    A Motta
    Department of Dermatology, University G D Annunzio, Via dei Vestini, 66100 Chieti, Italy
    J Eur Acad Dermatol Venereol 17:313-5. 2003
    ..We describe a case of lupus vulgaris in a 33-year-old woman who had a 5-year history of a slowly growing plaque on her neck...
  43. ncbi Autoantibodies to the epidermal growth factor receptor in systemic sclerosis, lupus, and autoimmune mice
    Stephanie Planque
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Internal Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    FASEB J 17:136-43. 2003
    ..exEGFR-binding autoantibodies was increased in scleroderma (systemic sclerosis) patients and to a lesser extent in lupus patients...
  44. ncbi Complement-fixing properties of antinuclear antibodies distinguish drug-induced lupus from systemic lupus erythematosus
    R L Rubin
    Department of Molecular Genetics and Microbiology, University of New Mexico Medical School, Albuquerque, New Mexico 87131, USA
    Lupus 13:249-56. 2004
    ..properties of antinuclear antibodies (CANA) in three well-defined and clinically-related patient groups: systemic lupus erythematosus (SLE), drug-induced lupus (DIL) and drug-induced autoimmunity (DIA)...
  45. ncbi Tuberculosis in a child presenting as asymptomatic oropharyngeal and laryngeal lesions
    S Magina
    Department of Dermatology, Faculty of Medicine, Hospital S Joao, Porto, Portugal
    Pediatr Dermatol 20:429-31. 2003
    ..The Mantoux test was strongly positive with a vesicular response. A diagnosis of mucocutaneous lupus vulgaris and scrofuloderma secondary to cervical tuberculous lymphadenitis was made...
  46. pmc T-bet regulates IgG class switching and pathogenic autoantibody production
    Stanford L Peng
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Proc Natl Acad Sci U S A 99:5545-50. 2002
    ..This function contributes critically to the pathogenesis of murine lupus, where the absence of T-bet strikingly reduces B cell-dependent manifestations, including autoantibody production, ..
  47. ncbi Induction of pathogenic anti-dsDNA antibodies is controlled on the level of B cells in a non-lupus prone mouse strain
    Dirk Langnickel
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Berlin, Germany
    J Clin Immunol 26:86-95. 2006
    The SmD1(83-119) peptide is a main target of autoantibodies and T cells in human and murine lupus, but its role in autoimmunity induction remains elusive...
  48. ncbi An increased frequency of autoantibody-inducing CD4+ T cells in pre-diseased lupus-prone mice
    Brian W Busser
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Immunol 16:1001-7. 2004
    Pathogenic autoantibody production in murine models of lupus is dependent on autoreactive CD4+ helper T cells...
  49. pmc Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice
    Eric S Sobel
    Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Environ Health Perspect 113:323-8. 2005
    Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects women more frequently than men...
  50. ncbi A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: role of thymic dendritic cells
    Marissa A Michaels
    Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 175:5857-65. 2005
    ..In the lupus-prone (SWR x NZB)F1 (SNF1) thymus, introduction of the lupus TCR transgene caused no deletion, but marked down-..
  51. ncbi Comprehensive findings on clinical, bacteriological, histopathological and therapeutic aspects of cutaneous tuberculosis
    K C Umapathy
    Department of Clinic, Tuberculosis Research Centre, Chetpet, Chennai, India
    Trop Med Int Health 11:1521-8. 2006
    ..To define the bacteriological and histological correlates of the three predominant clinical forms of cutaneous tuberculosis and to evaluate the efficacy of a 9-month daily regimen containing rifampicin and isoniazid...
  52. ncbi The effect of TNFalpha blockade on the antinuclear antibody profile in patients with chronic arthritis: biological and clinical implications
    L De Rycke
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Lupus 14:931-7. 2005
    ..by anti-TNFalpha therapy is associated with a relatively low incidence of immune-related complications such as lupus-like syndromes and demyelinating disease...
  53. ncbi Congenital heart block in neonatal lupus: the pediatric cardiologist's perspective
    Deborah M Friedman
    Department of Pediatrics, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
    Indian J Pediatr 69:517-22. 2002
    ..Abnormalities in the skin, liver and blood of neonates are also associated with anti-Ro/La antibodies, and are usually self-limiting; these manifestations and CHB are collectively referred to as neonatal lupus syndromes (NLS).
  54. ncbi Neonatal lupus
    David T Robles
    Department of Medicine, Division of Dermatology, University of Washington Medical Center, Seattle, WA 98105, USA
    Dermatol Online J 12:25. 2006
    ..The mother had been diagnosed with lupus erythematosus 2 years earlier but her disease was quiescent...
  55. ncbi Lupus vulgaris--a case diagnosed more than 20 years after onset
    Adel Sammain
    Department of Dermatology, University of Freiburg, Freiburg, Germany
    J Dtsch Dermatol Ges 4:958-60. 2006
    ..After several months of antituberculous treatment with isoniazid, rifampicin, ethambutol and pyrazinamide, the lesion resolved...
  56. ncbi Any increased risk of autoimmune disease?
    R Cimaz
    Department of Pediatrics, Istituti Clinici di Perfezionamento, Milano, Italy
    Lupus 13:736-9. 2004
    Autoimmune diseases such as systemic lupus erythematosus (SLE) are known to have a strong genetic component, therefore the risk of autoimmune disease might be increased in family members of patients with SLE...
  57. ncbi The role of porcine factor VIII in the management of unexpected bleeding episodes
    L M Aledort
    Department of Hemophilia, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1006, New York, NY, USA
    Haemophilia 8:17-9; discussion 28-32. 2002
    ..Case studies will be presented that offer important differential diagnoses. The prevalence and indications for the use of this biological replacement therapy will be discussed...
  58. ncbi Environment versus genetics in autoimmunity: a geneticist's perspective
    C Mohan
    Department of Internal Medicine Rheumatology, University of Texas Southwestern Medical School, Dallas, TX 75390 8884, USA
    Lupus 15:791-3. 2006
    ..Though lupus is used as an example in this essay, the proposed model is envisaged to operate in other autoimmune diseases as ..
  59. ncbi Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma
    A Richard Kitching
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Nephrol 15:1764-74. 2004
    IL-12 and IFN-gamma play key roles in murine lupus and planted antigen models of glomerulonephritis. However, their roles in renal organ-specific autoimmunity are unknown...
  60. pmc SH2D1A regulates T-dependent humoral autoimmunity
    Jonathan D Hron
    Washington University School of Medicine, Campus Box 8045, CSRB 6617, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:261-6. 2004
    ..Deficiency in SH2D1A protects mice from an experimental model of lupus, including the development of hypergammaglobulinemia, autoantibodies including anti-double stranded DNA, and renal ..
  61. ncbi The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis
    S Kodama
    Harvard Medical School and Massachusetts General Hospital East, Boston, 02192, USA
    Cell Mol Life Sci 62:1850-62. 2005
    ..Treatment with TNF-alpha, by destroying autoreactive T cells, appears to be a highly targeted strategy to interrupt the pathogenesis of type 1 diabetes, lupus and certain forms of autoimmunity.
  62. pmc Diagnostic associations in a large and consecutively identified population positive for anti-SSA and/or anti-SSB: the range of associated diseases differs according to the detailed serotype
    I Peene
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Ann Rheum Dis 61:1090-4. 2002
    ..To determine the diagnostic distribution in a consecutive anti-SSA and/or anti-SSB positive population...
  63. pmc A comparison between the Farr radioimmunoassay and a new automated fluorescence immunoassay for the detection of antibodies against double stranded DNA in serum
    R H W M Derksen
    Department of Rheumatology and Clinical Immunology, University Medical Centre, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 61:1099-102. 2002
    To compare test characteristics of the Farr radioimmunoassay and an automated fluorescence immunoassay (ELIA dsDNA test) for the diagnosis of systemic lupus erythematosus (SLE).
  64. ncbi Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
    Lixin Rui
    ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Nat Immunol 4:594-600. 2003
    CpG sequences in self-DNA are an important potential trigger for autoantibody secretion in systemic lupus and other systemic autoimmune disorders...
  65. ncbi Central role of defective apoptosis in autoimmunity
    W M Kuhtreiber
    Immunobiology Laboratory, Massachusetts General Hospital, and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Mol Endocrinol 31:373-99. 2003
    ..In murine models of autoimmune lupus, mutations in cell death receptor Fas (CD95) and its ligand, FasL (CD95 L), have been identified...
  66. ncbi [The red face]
    Ch Schuster
    Dermatologische Klinik, Universitatsspital Zurich
    Praxis (Bern 1994) 93:1727-32. 2004
    ..We would like to concentrate on the practical aspects of facial erythema as a presenting symptom, rather than discussing every disease in detail...
  67. ncbi Cutaneous Mycobacterium fortuitum infection mimicking lupus vulgaris
    Y C Lin
    Department of Dermatology, National Taiwan University Hospital, 7, Chung Shan South Road, Taipei, Taiwan
    Br J Dermatol 147:170-3. 2002
    We report a woman with a lupus vulgaris-like skin eruption caused by Mycobacterium fortuitum...
  68. ncbi [Lupus miliaris disseminatus faciei: 6 cases]
    R Borhan
    Service de Dermatologie 2, Hopital Saint Louis, Paris
    Ann Dermatol Venereol 132:526-30. 2005
    b>Lupus miliaris disseminatus faciei is recognized by all authors as a unique entity, despite many appellations for this disease. In fact, the real origin and the treatment of this affection are unknown...
  69. ncbi [Pulmonary tuberculosis presenting as tubercular lupus]
    S Fays
    Service de Dermatologie, Hopital Fournier, Nancy
    Rev Mal Respir 19:519-21. 2002
    ..b>Lupus vulgaris is the most common cutaneous manifestation of tuberculosis in industrialised countries, but nevertheless ..
  70. ncbi The ever-expanding association between rheumatologic diseases and tuberculosis
    Carlos Franco-Paredes
    Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA
    Am J Med 119:470-7. 2006
    ..inhibitors; (3) antimycobacterial drug-induced rheumatologic syndromes, including tendinopathy, drug-induced lupus, and others; and (4) reactive immunologic phenomena caused by TB, such as reactive arthritis, erythema nodosum, ..
  71. ncbi "Were-wolf" cutaneous tuberculosis
    Vikram K Mahajan
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, India
    Int J Lepr Other Mycobact Dis 72:473-9. 2004
    b>Lupus vulgaris is a variant of cutaneous tuberculosis. Its more destructive and mutilating clinical forms have become rarer in consonance of a general decline of cutaneous tuberculosis...
  72. ncbi Polymerase chain reaction based detection of Mycobacterium tuberculosis complex in lupus vulgaris: a case report
    O Baylan
    Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy and Medical School, Ankara, Turkey
    Int J Tuberc Lung Dis 8:1147-50. 2004
    b>Lupus vulgaris (LV), the commonest of all forms of cutaneous tuberculosis, can affect the earlobes...
  73. ncbi Lupus vulgaris over a tattoo mark--inoculation tuberculosis
    A Ghorpade
    Department of Dermatology, Venereology and Leprosy, JLN Hospital and Research Centre, Bhilai Steel Plant, Bhilai, India
    J Eur Acad Dermatol Venereol 17:569-71. 2003
    b>Lupus vulgaris developing after tattooing and remaining exclusively confined to it, in a 40-year-old-lady is reported. The tattooing was done one year earlier by a roadside tattoo artist...
  74. ncbi [Cutaneous lupus--current problem in dermatology]
    Agnieszka Bielicka-Jedrzejczak
    Oddział Skórno Wenerologiczny SPZOZ w Kutnie
    Przegl Lek 61:199-201. 2004
    A case of lupus vulgaris in 83-year-old woman is presented. Skin lesions appeared 20 years earlier and till now were not treated. Cutaneous tuberculosis is a particular form of infection caused by Mycobacterium tuberculosis...
  75. ncbi Disseminated lupus vulgaris
    Paolo Gisondi
    Istituto Dermopatico dell Immacolata, IRCCS, Via Monti di Creta 104, 00167 Rome, Italy
    Eur J Dermatol 13:500-2. 2003
    b>Lupus vulgaris is the most common form of cutaneous tuberculosis, and usually presents as a solitary lesion on the face. We report two patients with multiple lesions on different skin areas...
  76. ncbi Psoriasiform lupus vulgaris with 30 years duration
    Adam Reich
    Department of Dermatology, Venereology and Allergology, University of Medicine, Wroclaw, Poland
    Scand J Infect Dis 38:556-8. 2006
    b>Lupus vulgaris is a progressive form of cutaneous tuberculosis occurring in a person with a moderate to high degree of immunity. It is the most common type of cutaneous tuberculosis...
  77. ncbi Antibodies to sulfatide in cerebrospinal fluid of patients with multiple sclerosis
    Amjad A Ilyas
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Neuroimmunol 139:76-80. 2003
    ..The data demonstrate a humoral response to sulfatide in the CSF of patients with MS...
  78. ncbi Neonatal lupus manifests as isolated neutropenia and mildly abnormal liver functions
    Sivalingam Kanagasegar
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
    J Rheumatol 29:187-91. 2002
    Neonatal lupus is characterized by typical clinical features and the presence of maternal autoantibodies. Mothers can have systemic lupus erythematosus (SLE) or Sjögren's syndrome, but are commonly not affected with any clinical disease...
  79. ncbi Cerebral ultrasound findings in neonatal lupus syndrome
    A A Zuppa
    Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy
    Biol Neonate 86:230-4. 2004
    A prospective study was performed enrolling 11 newborns with neonatal lupus syndrome (NLS) and 22 control newborns to investigate cerebral ultrasound (US) anomalies and their relationship with clinical neurological signs and laboratory ..
  80. ncbi Bone marrow transplantation: a new strategy for intractable diseases
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Drugs Today (Barc) 38:103-11. 2002
    ..allogeneic (not autologous) bone marrow transplantation can be used to treat autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, immune thrombocytic purpura, insulin-dependent diabetes mellitus, chronic ..
  81. doi The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease
    Cynthia M Magro
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Am Acad Dermatol 59:822-33. 2008
    ....
  82. ncbi A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosus
    Elizabeth W Karlson
    Brigham and Women s Hospital, and Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Boston, Massachusetts 02115, USA
    Arthritis Rheum 50:1832-41. 2004
    ..study, we previously identified 2 potentially modifiable risk factors for adverse outcomes in systemic lupus erythematosus (SLE): self-efficacy and social support...
  83. ncbi Systemic lupus erythematosus in three ethnic groups. XII. Risk factors for lupus nephritis after diagnosis
    H M Bastian
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Lupus 11:152-60. 2002
    The purpose of this study was to determine the cumulative incidence of lupus nephritis (LN) and the factors predictive of its occurrence in a multiethnic systemic lupus erythematosus (SLE) cohort...
  84. ncbi Anti-chromatin and anti-C1q antibodies in systemic lupus erythematosus compared to other systemic autoimmune diseases
    A Braun
    Department of Internal Medicine I Nephrology, University Hospital of Heidelberg, Germany
    Scand J Rheumatol 36:291-8. 2007
    To evaluate the prevalence, sensitivity, and specificity of anti-chromatin and anti-C1q antibodies in systemic lupus erythematosus (SLE) and lupus nephritis compared to small vessel vasculitis and other connective tissue diseases...
  85. pmc Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies
    Claudia Azucena Palafox Sánchez
    Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético IIRSME, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco, CP 44340, Mexico
    Arthritis Res Ther 11:R27. 2009
    Systemic lupus erythematosus is characterized by production of autoantibodies to RNA or DNA-protein complexes such as small nuclear ribonucleoproteins (snRNPs). A role of Epstein-Barr virus in the pathogenesis has been suggested...
  86. doi Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosus
    Adriana Danowski
    Rheumatology Department, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore MD 21205, USA
    J Rheumatol 36:1195-9. 2009
    ..syndrome (APS) is characterized by thrombosis (venous and arterial) and pregnancy loss in conjunction with the lupus anticoagulant, IgG or IgM anticardiolipin, or IgG or IgM anti-beta2-glycoprotein I...
  87. ncbi [Comparison of various cyclophosphamide treatment regimens on the course and outcome of lupus nephritis ]
    Radimila Petrović
    Institute of Rheumatology, Belgrade
    Srp Arh Celok Lek 130:19-25. 2002
    ..drugs, particularly cyclophosphamide, are widely accepted as the treatment of choice for severe, proliferative lupus nephritis...
  88. ncbi Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE
    W S Uhm
    The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea
    Lupus 11:227-33. 2002
    Systemic lupus erythematosus (SLE) is an inflammatory multisystem disease of unknown etiology with immunologic aberrations. Many studies have shown that genetic and environmental factors are implicated in the development of SLE...
  89. ncbi Systemic lupus erythematosus in Tunisia: demographic and clinical analysis of 100 patients
    M H Houman
    Department of Internal Medicine, La Rabta University Hospital, Tunis, Tunisia
    Lupus 13:204-11. 2004
    There is a wide variation in the natural history of systemic lupus erythematosus (SLE) among different ethnic and geographical groups...
  90. pmc Cutaneous manifestations of systemic lupus erythematosus in a tertiary referral center
    Alakes Kumar Kole
    Institute of Post Graduate Medical Education and Research, Department of Rheumatology and Clinical Immunology
    Indian J Dermatol 54:132-6. 2009
    BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease with multiorgan involvement. The skin is the second most commonly affected organ...
  91. doi Frequency of neuro-psychiatric dysfunction in anti-SSA/SSB exposed children with and without neonatal lupus
    A D Askanase
    Department of Medicine, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10016, USA
    Lupus 19:300-6. 2010
    Neonatal lupus is a model of passively acquired autoimmunity whereby anti-SSA/Ro-SSB/La antibodies target the fetal heart and neonatal skin in a minority of cases...
  92. ncbi [Lupus nephritis: retrospective analysis of the course of the disease]
    Ljubica Djukanovic
    Department of Nephrology, Clinical Centre of Serbia, Belgrade
    Srp Arh Celok Lek 130:26-31. 2002
    Systemic lupus erythematosus is a multisystemic autoimmune disease characterized by various clinical manifestations, as well as unpredictable course and therapy response...
  93. pmc Necrotizing and crescentic lupus nephritis with antineutrophil cytoplasmic antibody seropositivity
    Samih H Nasr
    Department of Pathology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC14 224, New York, NY 10032, USA
    Clin J Am Soc Nephrol 3:682-90. 2008
    b>Lupus nephritis is a classic immune complex glomerulonephritis. In contrast, antineutrophil cytoplasmic antibodies are associated with necrotizing and crescentic glomerulonephritis, in the absence of significant immune deposits...
  94. ncbi The effect of menopause on disease activity in systemic lupus erythematosus
    Murray B Urowitz
    University of Toronto Lupus Clinic and Toronto Western Hospital, Edith Cavell Wing, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada
    J Rheumatol 33:2192-8. 2006
    To determine the effect of menopause on disease activity and course of systemic lupus erythematosus (SLE).
  95. pmc Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study
    Jessica J Manson
    Centre for Rheumatology Research, University College London, Windeyer Institute, 46 Cleveland Street, London W1T 4JF, UK
    Arthritis Res Ther 11:R154. 2009
    Glomerulonephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Deposition of autoantibodies in the glomeruli plays a key role in the development of lupus nephritis (LN)...
  96. doi Measurement of autoantibodies using multiplex methodology in patients with systemic lupus erythematosus
    John G Hanly
    Division of Rheumatology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol Methods 352:147-52. 2010
    Autoantibodies are central to the diagnosis and assessment of systemic lupus erythematosus (SLE)...
  97. ncbi The risk of thrombosis in patients with lupus anticoagulants is predicted by their specific coagulation profile
    M Galli
    Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy
    Thromb Haemost 81:695-700. 1999
    b>Lupus anticoagulants belong to the family of antiphospholipid antibodies...
  98. pmc Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis
    Christopher Sjöwall
    Rheumatology AIR, Clinical and Experimental Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Arthritis Res Ther 11:R188. 2009
    Serum levels of C-reactive protein (CRP) seldom reflect disease activity in systemic lupus erythematosus (SLE)...
  99. ncbi The lupus band: do the autoantibodies target collagen VII?
    A M Alahlafi
    Department of Dermatology, Oxford Radcliffe Hospital, Oxford OX3 7LJ, UK
    Br J Dermatol 150:504-10. 2004
    ..Although the pattern of immunofluorescence in those diseases is similar to the lupus band, little is known about the origin and pathogenesis of the lupus band...
  100. doi Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection
    X Y Lu
    Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Lupus 19:689-95. 2010
    ..chemokine and adhesion molecule profiles in cerebrospinal fluid from patients with neuropsychiatric systemic lupus erythematosus and systemic lupus erythematosus with central nervous system infection...
  101. ncbi The basement membrane zone in patients with systemic lupus erythematosus: immunofluorescence studies in the skin, kidney and amniochorion
    A M Alahlafi
    Department of Dermatology, Oxford Radcliffe Hospital, Oxford, UK
    Lupus 13:594-600. 2004
    ..studies suggest that the basement membrane zone (BMZ) is the main target of tissue pathology in cutaneous lupus erythematosus (LE). The BMZ is characteristically thickened and is the site of deposition of autoantibodies in LE...

Research Grants90

  1. Treatment of SLE with N-acetylcysteine
    Andras Perl; Fiscal Year: 2010
    ..The pathogenesis of systemic lupus erythematosus (SLE), a potentially fatal autoimmune disease of unknown etiology, is characterized by abnormal T-..
  2. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs more in females than males at a ratio of 9:1...
  3. Clinical Component
    BRIAN KOTZIN; Fiscal Year: 2003
    ..The Denver ACE includes groups doing clinical investigation on type 1 diabetes, systemic lupus erythematosus and lupus nephritis, rheumatoid arthritis, systemic sclerosis, multiple sclerosis, autoimmune ..
  4. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs more in females than males at a ratio of 9:1...
  5. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2004
    DESCRIPTION (Taken from the application): Neonatal lupus is currently considered a model of passively acquired autoimmunity whereby immune abnormalities in the mother (who may have systemic lupus erythematosus, Sjogrens syndrome, or be ..
  6. ANTIBODIES WITH PROTHROMBINASE ACTIVITY IN LUPUS
    Perumal Thiagarajan; Fiscal Year: 2003
    ..Prothrombin binding autoantibodies from lupus patients are clinically associated with thrombosis, but the association is paradoxical, because conventional ..
  7. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2009
    Antibodies to double stranded (ds) DNA are not only highly specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease manifestation...
  8. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2009
    Antibodies to double stranded (ds) DNA are not only highly specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease manifestation...
  9. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
    DESCRIPTION: (Adapted from the Investigator's abstract): Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by immune complex glomerulonephritis and infiltration of activated macrophages into the ..
  10. Genetic and Immunological Impact of the HRES-1/Rab4 Locus in SLE
    Andras Perl; Fiscal Year: 2010
    ABSTRACT Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by circulating antinuclear autoantibodies and the dysfunction of T and B lymphocytes...
  11. Prediction of Lupus Outcome by Gene Expression Patterns
    Robert Winchester; Fiscal Year: 2006
    ..mechanistic studies to define the gene expression profiles of glomeruli isolated from biopsy sections of lupus glomerulonephritis with the overall goals of determining whether the glomerular gene expression phenotype will ..
  12. Pathogenesis on Autoantibodies in Pristane-Induced Lupus
    Westley Reeves; Fiscal Year: 2007
    Patients with lupus develop extremely high levels of autoantibodies to self-antigens ribonucleoproteins and DNA. It is unclear how the B cells producing these autoantibodies escape self-tolerance...
  13. Pathogenesis on Autoantibodies in Pristane-Induced Lupus
    Westley H Reeves; Fiscal Year: 2010
    Patients with lupus develop extremely high levels of autoantibodies to self-antigens ribonucleoproteins and DNA. It is unclear how the B cells producing these autoantibodies escape self-tolerance...
  14. Lysosomal phospholipase A2 in autoimmune disease
    JAMES ALAN SHAYMAN; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus historically has been and still remains a poorly understood autoimmune disorder...
  15. Lysosomal phospholipase A2 in autoimmune disease
    JAMES ALAN SHAYMAN; Fiscal Year: 2010
    Systemic lupus erythematosus historically has been and still remains a poorly understood autoimmune disorder...
  16. CELL MEDIATED RENAL INJURY IN LUPUS
    VICKI KELLEY; Fiscal Year: 2004
    ..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis...
  17. Inhibition of lupus nephritis in IRF-1 deficient mice
    Christopher Reilly; Fiscal Year: 2002
    MRL/Ipr mice spontaneously develop immune complex glomerulonephritis similar to human lupus. Prior to overt disease manifestations, MRL/lpr mice overproduce nitric oxide (NO) secondary to increased gene expression of inducible nitric ..
  18. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2010
    Systemic lupus erythematosus (SLE), a multi-system disorder with significant morbidity and mortality affects predominantly females in their reproductive years...
  19. Sex Chromosome Effects in Lupus
    Rhonda Voskuhl; Fiscal Year: 2007
    Systemic lupus erythematosus (SLE) affects females much more frequently than males with a ratio of 9:1. Many murine models of lupus also demonstrate a greater incidence in females as compared to males...
  20. Somatic hypermutation and class switching in autoimmunity
    Paolo Casali; Fiscal Year: 2011
    ..hypermutation (SHM) and class switch DNA recombination (CSR) in systemic autoimmunity, particularly systemic lupus. Like antibodies to microbial pathogens, most pathogenic autoantibodies are somatically hypermutated and class-..
  21. Somatic hypermutation and class switching in autoimmunity
    Paolo Casali; Fiscal Year: 2010
    ..hypermutation (SHM) and class switch DNA recombination (CSR) in systemic autoimmunity, particularly systemic lupus. Like antibodies to microbial pathogens, most pathogenic autoantibodies are somatically hypermutated and class-..
  22. Efficacy Measures for Pediatric Lupus Studies
    Hermine Brunner; Fiscal Year: 2007
    Childhood-onset Systemic Lupus Erythematosus (cSLE) is a severe autoimmune disease and better medications are urgently needed to decrease its mortality...
  23. Agonists and Antagonists of Neuropsychiatric Lupus
    Keith B Elkon; Fiscal Year: 2010
    Agonists and Antagonists of Neuropsychiatric Lupus Project Summary Neuropsychiatric systemic lupus erythematosus (NPSLE) is a common and potentially lethal form of lupus...
  24. T Cell Tolerance & Autoimmunity to Nuclear Antigen La
    A Darise Farris; Fiscal Year: 2010
    ..nuclear antigens are a major class of autoantigen targeted in systemic autoimmune diseases, including systemic lupus erythematosus (SLE) and Sjvgren's syndrome (SS)...
  25. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2004
    Systemic lupus erythematosus (SLE) is an autoimmune disorder affecting multiple organs with considerable morbidity and mortality...
  26. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    Systemic lupus erythematosus (SLE) is an autoimmune disease. The disease develops at a female-to-male ratio of 10:1...
  27. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2009
    Systemic lupus erythematosus (SLE) is an autoimmune disease. The disease develops at a female-to-male ratio of 10:1...