bacteremia

Summary

Summary: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.

Top Publications

  1. pmc Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia
    Peter B Lockhart
    Department of Oral Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
    J Am Dent Assoc 140:1238-44. 2009
  2. ncbi Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group
    C von Eiff
    Institute of Medical Microbiology, University of Munster, Germany
    N Engl J Med 344:11-6. 2001
  3. pmc Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis
    Elizabeth A Reddy
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lancet Infect Dis 10:417-32. 2010
  4. ncbi Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections
    N Deborah Friedman
    Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
    Ann Intern Med 137:791-7. 2002
  5. pmc Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
    J Anthony G Scott
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya org
    Lancet 378:1316-23. 2011
  6. ncbi Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
    Ulrich Seybold
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Clin Infect Dis 42:647-56. 2006
  7. ncbi Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
    Sara E Cosgrove
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 36:53-9. 2003
  8. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
  9. ncbi Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome
    Rachel N Bronzan
    Blantyre Malaria Project, Blantyre, Malawi
    J Infect Dis 195:895-904. 2007
  10. doi Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?
    Kyle J Popovich
    Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 46:787-94. 2008

Research Grants

  1. LISTERIA AND SHIGELLA USE ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 2010
  2. Pacific-Southwest Ctr for Biodefense & Emerg Infect Dis*
    Alan Barbour; Fiscal Year: 2007
  3. LISTERIA USES HOST CELL ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 1993
  4. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2003
  5. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
  6. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
  7. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2007
  8. In Vivo Virulence Gene Expression in Acute Otitis Media
    Ha Sheng Li Korotky; Fiscal Year: 2007
  9. LISTERIA AND SHIGELLA USE HOST CELL ACTIN
    Frederick Southwick; Fiscal Year: 2006
  10. CONJUGAL TRANSFER OF BACTEROIDES ANTIBIOTIC RESISTANCES
    Abigail Salyers; Fiscal Year: 1999

Detail Information

Publications272 found, 100 shown here

  1. pmc Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia
    Peter B Lockhart
    Department of Oral Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
    J Am Dent Assoc 140:1238-44. 2009
    ..The authors conducted a study to determine if poor oral hygiene or dental disease are risk factors for developing bacteremia after toothbrushing or single-tooth extraction.
  2. ncbi Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group
    C von Eiff
    Institute of Medical Microbiology, University of Munster, Germany
    N Engl J Med 344:11-6. 2001
    ..We examined S. aureus isolates from blood and from nasal specimens to determine whether the organisms in the bloodstream originated from the patient's own flora...
  3. pmc Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis
    Elizabeth A Reddy
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lancet Infect Dis 10:417-32. 2010
    ..Improved clinical microbiology services and reassessment of empirical treatment guidelines that account for the epidemiology of bloodstream infections might contribute to better outcomes...
  4. ncbi Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections
    N Deborah Friedman
    Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
    Ann Intern Med 137:791-7. 2002
    ..Bloodstream infections occurring in persons residing in the community, regardless of whether those persons have been receiving health care in an outpatient facility, have traditionally been categorized as community-acquired infections...
  5. pmc Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
    J Anthony G Scott
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya org
    Lancet 378:1316-23. 2011
    ..Many investigators have suggested that malaria infection predisposes individuals to bacteraemia. We tested this hypothesis with mendelian randomisation studies of children with the malaria-protective phenotype of sickle-cell trait (HbAS)...
  6. ncbi Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
    Ulrich Seybold
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Clin Infect Dis 42:647-56. 2006
    ..Whether community-associated methicillin-resistant Staphylococcus aureus (MRSA) genotypes (e.g., USA300) are a major cause of bloodstream infections (BSIs) and health care-associated infections has been poorly defined...
  7. ncbi Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
    Sara E Cosgrove
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 36:53-9. 2003
    ..was performed to summarize the impact of methicillin-resistance on mortality in Staphylococcus aureus bacteremia. A search of the MEDLINE database for studies published during the period of 1 January 1980 through 31 December ..
  8. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  9. ncbi Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome
    Rachel N Bronzan
    Blantyre Malaria Project, Blantyre, Malawi
    J Infect Dis 195:895-904. 2007
    Previous prospective studies of bacteremia in African children with severe malaria have mainly included children with cerebral malaria, and no study has examined the impact of human immunodeficiency virus (HIV) infection...
  10. doi Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?
    Kyle J Popovich
    Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 46:787-94. 2008
    ..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
  11. doi Community-onset bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli: risk factors and prognosis
    Jesús Rodríguez-Baño
    Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Seville, Spain
    Clin Infect Dis 50:40-8. 2010
    ..We investigated the prevalence and risk factors for COBSI due to ESBLEC, and described their clinical features and the impact of COBSI caused by ESBLEC on 14-day mortality...
  12. pmc Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
    Cornelis P C de Jager
    Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, Tolbrugstraat 11, 5200 ME s Hertogenbosch, The Netherlands
    Crit Care 14:R192. 2010
    Absolute lymphocytopenia has been reported as a predictor of bacteremia in medical emergencies...
  13. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
    ..However, the relationship between the clinical presentation and bacterial factors remains unclear. The aim of this study was to investigate the clinical features of patients and the serotype and ribotype of K pneumoniae liver abscess...
  14. pmc Risk factors and prognosis of nosocomial bloodstream infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli
    Jesús Rodríguez-Baño
    Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, and Departamento de Medicina, Universidad de Seville, Avda Dr Fedriani, 3, Seville 41009, Spain
    J Clin Microbiol 48:1726-31. 2010
    ..The previous use of oxyimino-beta-lactams was the only modifiable risk factor found. Resistance to drugs other than penicillins and cephalosporins was associated with increased mortality...
  15. doi Influence of genospecies of Acinetobacter baumannii complex on clinical outcomes of patients with acinetobacter bacteremia
    Yu Chung Chuang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 52:352-60. 2011
    ..baumannii (genospecies 2) from other genospecies. Genospecies typing offers a potential tool to determine whether there are major differences in pathogenicity among the genospecies...
  16. pmc Invasive salmonellosis among children admitted to a rural Tanzanian hospital and a comparison with previous studies
    George Mtove
    National Institute for Medical Research Amani Centre, Tanga, Tanzania
    PLoS ONE 5:e9244. 2010
    ..We compared our main findings with those from previous studies among children in sub-Saharan Africa...
  17. pmc Intensity of rainfall and severity of melioidosis, Australia
    Bart J Currie
    Menzies School of Health Research and Flinders University, Darwin, Northern Territory, Australia
    Emerg Infect Dis 9:1538-42. 2003
    ..70 [confidence interval [CI] 1.09 to 2.65]), bacteremia (OR 1.93 [CI 1.24 to 3.02]), septic shock (OR 1.94 [CI 1.14 to 3.29]), and death (OR 2.50 [CI 1.36 to 4.57])...
  18. pmc Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis
    Nele Wellinghausen
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Ulm, Albert Einstein Allee 23, D 89081 Ulm, Germany
    J Clin Microbiol 47:2759-65. 2009
    ..sepsis, or neutropenic fever, a new commercial PCR test (SepsiTest; Molzym) was evaluated for rapid diagnosis of bacteremia. The test comprises a universal PCR from the 16S rRNA gene, with subsequent identification of bacteria from ..
  19. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target...
  20. doi Emergence of extended-spectrum β-lactamase-producing escherichia coli as a cause of community-onset bacteremia in South Korea: risk factors and clinical outcomes
    Sun Hee Park
    Division of Infectious Disease, Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea
    Microb Drug Resist 17:537-44. 2011
    To define the risk factors and clinical outcomes of community-onset bacteremia caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBLEC), we analyzed 50 consecutive cases of community-onset bacteremia caused by ..
  21. pmc Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe
    Marlieke E A de Kraker
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS Med 8:e1001104. 2011
    ....
  22. ncbi Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia
    Ki Tae Kwon
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Seoul 135 710, Korea
    J Antimicrob Chemother 59:525-30. 2007
    ..To investigate the impact of imipenem resistance on the mortality rate among patients with Acinetobacter bacteraemia...
  23. pmc Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis
    Christian Østergaard
    Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev, Denmark
    BMC Infect Dis 10:1. 2010
    b>Bacteremia and systemic complications both play important roles in brain pathophysiological alterations and the outcome of pneumococcal meningitis...
  24. ncbi Non-typhoidal salmonella bacteraemia among HIV-infected Malawian adults: high mortality and frequent recrudescence
    Melita A Gordon
    Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi
    AIDS 16:1633-41. 2002
    ..We aimed to describe the presentation and outcome of NTS bacteraemia, the pattern of recurrence, and to determine whether recurrence results from re-infection or recrudescence...
  25. doi Salmonella infections in immunocompromised adults
    Melita A Gordon
    Division of Gastroenterology, Henry Wellcome Laboratories, Nuffield Building, Crown Street, Liverpool University L69 3GE, UK
    J Infect 56:413-22. 2008
    ..This review will describe the presentation and pathogenesis of NTS in different categories of immunocompromised adults, contrasted to typhoid fever...
  26. pmc Bacteremia in Kenyan children presenting with malaria
    T Were
    University of New Mexico Kenya Medical Research Institute, Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kisumu, Kenya
    J Clin Microbiol 49:671-6. 2011
    Since the etiologies and clinical outcomes of bacteremia in children with Plasmodium falciparum infections, particularly in areas of holoendemic malaria transmission, are largely unexplored, blood cultures and comprehensive clinical, ..
  27. pmc Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns
    Wen Chien Ko
    National Cheng Kung University Medical College, Taiwan
    Emerg Infect Dis 8:160-6. 2002
    We initiated a worldwide collaborative study, including 455 episodes of bacteremia, to elucidate the clinical patterns of Klebsiella pneumoniae. Historically, community-acquired pneumonia has been consistently associated with K...
  28. pmc Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study
    Bjørn Blomberg
    Department of Medicine, Haukeland University Hospital, Bergen, Norway
    BMC Infect Dis 7:43. 2007
    ..Bloodstream infection is a common cause of hospitalization, morbidity and death in children. The impact of antimicrobial resistance and HIV infection on outcome is not firmly established...
  29. ncbi Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States
    Hilmar Wisplinghoff
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany
    Clin Infect Dis 36:1103-10. 2003
    ..The source of BSI was not determined for 57% of patients. The crude mortality rate was 36% for neutropenic patients and 31% for nonneutropenic patients...
  30. ncbi Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 60:913-20. 2007
    ..We performed a systematic review and meta-analysis to examine the impact of extended-spectrum beta-lactamase (ESBL) production on mortality and delay in effective therapy in Enterobacteriaceae bacteraemia...
  31. pmc The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Invest 118:1553-62. 2008
    Nontyphoidal strains of Salmonella (NTS) are a common cause of bacteremia among African children. Cell-mediated immune responses control intracellular infection, but they do not protect against extracellular growth of NTS in the blood...
  32. ncbi Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation
    Lone Forner
    Department of Periodontology, University of Copenhagen, Copenhagen, Denmark
    J Clin Periodontol 33:401-7. 2006
    SCIENTIFIC RATIONALE FOR STUDY: Bacteremia occurs with various frequency after oral procedures. Periodontal disease may affect the incidence, magnitude, duration and bacterial spectrum of bacteremia...
  33. doi Bacillus cereus bacteremia outbreak due to contaminated hospital linens
    T Sasahara
    Department of Infection and Immunity, School of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    Eur J Clin Microbiol Infect Dis 30:219-26. 2011
    We describe an outbreak of Bacillus cereus bacteremia that occurred at Jichi Medical University Hospital in 2006. This study aimed to identify the source of this outbreak and to implement appropriate control measures...
  34. doi Clinical impact of fluoroquinolone prophylaxis in neutropenic patients with hematological malignancies
    Yong Chong
    Department of Blood and Marrow Transplantation, Hara Sanshin Hospital, 1 8, Taihaku cho Hakata ku, Fukuoka, 812 0033, Japan
    Int J Infect Dis 15:e277-81. 2011
    ..This study assessed the effect of discontinuing quinolone prophylaxis on the etiology and the resistance pattern of blood culture isolates and on the prognosis among febrile neutropenic patients receiving chemotherapy...
  35. ncbi Bacteraemia complicating severe malaria in children
    J Berkley
    Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Trans R Soc Trop Med Hyg 93:283-6. 1999
    ..We recommend that young children with severe malaria be treated with broad-spectrum antibiotics in addition to antimalarial drugs...
  36. ncbi Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:2588-95. 2006
    ..To gain a better understanding of the epidemiology, microbiology, and outcomes of early-onset, culture-positive, community-acquired, healthcare-associated, and hospital-acquired bloodstream infections...
  37. doi Comparison of CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae isolates from patients with bacteremia
    Juyoun Shin
    Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Jangan ku, Suwon 440 746, South Korea
    J Infect 63:39-47. 2011
    ..coli and K. pneumoniae isolates that had been more prevalent before the recent increase of CTX-M-15 in Korea...
  38. ncbi Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection
    Ren Wen Tsay
    Division of Infectious Diseases and Tropical Medicine, Tri Service General Hospital, No 325, Section 2, Cheng Kung Road, Neihu, 114 Taipei, Taiwan
    Arch Intern Med 162:1021-7. 2002
    ..Although several epidemiological surveys of Klebsiella clinical isolates have been performed, few studies have correlated the clinical isolate with disease...
  39. pmc A decline in the incidence of invasive non-typhoidal Salmonella infection in The Gambia temporally associated with a decline in malaria infection
    Grant Mackenzie
    Medical Research Council United Kingdom The Gambia, Fajara, The Gambia
    PLoS ONE 5:e10568. 2010
    ..Malaria is a risk factor for invasive non-typhoidal Salmonella (NTS) infection in children. In the last 10 years, indices of malaria infection in The Gambia have fallen substantially...
  40. doi Periodontal bacteremia and various vascular diseases
    T Iwai
    Tsukuba Vascular Center and Buerger Disease Research Institute, Tatsuzawa, Moriya city, Japan
    J Periodontal Res 44:689-94. 2009
    ..Serum titer levels of each bacterium are now available and have shown a significant relationship between severity and individual differences...
  41. doi Salvage treatment for persistent methicillin-resistant Staphylococcus aureus bacteremia: efficacy of linezolid with or without carbapenem
    Hee Chang Jang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Clin Infect Dis 49:395-401. 2009
    Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high mortality rates, but no treatment strategy has yet been established...
  42. ncbi An outbreak in an intensive care unit of a strain of methicillin-resistant Staphylococcus aureus sequence type 239 associated with an increased rate of vascular access device-related bacteremia
    Jonathan D Edgeworth
    Department of Infection, Guy s and St Thomas National Health Service Foundation Trust, St Thomas Hospitals, London, SE1 7EH, UK
    Clin Infect Dis 44:493-501. 2007
    ..Patients in intensive care units are at high risk of developing methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. We report an epidemiological and bacterial genomic analysis of a 2-year outbreak in an intensive care unit of a ..
  43. doi Bartonella spp. bacteremia in high-risk immunocompetent patients
    Ricardo G Maggi
    Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Diagn Microbiol Infect Dis 71:430-7. 2011
    ..0%), were screened for antibodies by indirect immunofluorescence assays and for bacteremia using the BAPGM (Bartonella alpha Proteobacteria growth medium) platform...
  44. pmc LysGH15, a novel bacteriophage lysin, protects a murine bacteremia model efficiently against lethal methicillin-resistant Staphylococcus aureus infection
    Jingmin Gu
    College of Animal Science and Veterinary Medicine, Jilin University, Xi an Road 5333, Changchun 130062, People s Republic of China
    J Clin Microbiol 49:111-7. 2011
    ..01). Bacteremia in unprotected mice reached colony counts of about 10(7) CFU/ml within 3...
  45. pmc Novel structurally designed vaccine for S. aureus α-hemolysin: protection against bacteremia and pneumonia
    Rajan P Adhikari
    Integrated Biotherapeutics Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 7:e38567. 2012
    ..This vaccine candidate, denoted AT-62aa, was tested in pneumonia and bacteremia infection models using S. aureus strain Newman and the pandemic strain USA300 (LAC)...
  46. pmc Neurodevelopment of extremely preterm infants who had necrotizing enterocolitis with or without late bacteremia
    Camilia R Martin
    Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA
    J Pediatr 157:751-6.e1. 2010
    To evaluate neurodevelopment after necrotizing enterocolitis (NEC) and late bacteremia, alone and together.
  47. doi Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000-2006
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Infect Dis 198:336-43. 2008
    ..We sought to describe the epidemiological profile of S. aureus bacteremia and to assess whether the incidence and severity of and the antimicrobial resistance rates associated with this ..
  48. pmc Molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli isolates causing bacteremia in the Calgary Health Region from 2000 to 2007: emergence of clone ST131 as a cause of community-acquired infections
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, 9, 3535 Research Road NW, Calgary, Alberta, Canada
    Antimicrob Agents Chemother 53:2846-51. 2009
    ..was designed to characterize extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli isolates causing bacteremia over an 8-year period (2000 to 2007) in a large well-defined geographical region...
  49. pmc Relation between lymphopenia and bacteraemia in UK adults with medical emergencies
    D H Wyllie
    Nuffield Departments of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 57:950-5. 2004
    ..To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia...
  50. ncbi Prevalence, duration and aetiology of bacteraemia following dental extractions
    I Tomas
    Department of Special Needs, School of Medicine and Dentistry, Santiago de Compostela University, Santiago de Compostela, and Research Laboratory, Department of Clinical Microbiology, Xeral Cies Hospital, Vigo, Spain
    Oral Dis 13:56-62. 2007
    ..To investigate the prevalence, duration and aetiology of bacteraemia following dental extractions, analysing the factors affecting its development...
  51. pmc Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment
    Mario Tumbarello
    Istituto Malattie Infettive, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Antimicrob Agents Chemother 51:1987-94. 2007
    ..Prompt initiation of effective antimicrobial treatment is essential in patients with ESBL-BSI, and empirical decisions must be based on a sound knowledge of the local distribution of pathogens and their susceptibility patterns...
  52. ncbi Bacteraemia following periodontal procedures
    Denis F Kinane
    University of Louisville School of Dentistry, Louisville, KY 40292, USA
    J Clin Periodontol 32:708-13. 2005
    ..These systemic conditions could be initiated or detrimentally influenced by the repeated entry of bacteria into the bloodstream...
  53. ncbi Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection
    Vance G Fowler
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 196:738-47. 2007
    ..The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear...
  54. ncbi Screening for extended-spectrum beta-lactamase-producing Enterobacteriaceae among high-risk patients and rates of subsequent bacteremia
    P Reddy
    Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 45:846-52. 2007
    ..However, the role of routine inpatient surveillance for ESBL colonization in predicting related infection is unclear...
  55. pmc Bacteremic typhoid fever in children in an urban slum, Bangladesh
    W Abdullah Brooks
    ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1000, Bangladesh
    Emerg Infect Dis 11:326-9. 2005
    ..The relative risk for preschool children compared with older persons was 8.9. Our regression model showed that these children were clinically ill, which suggests a role for preschool immunization...
  56. pmc Bacteraemia in patients admitted to an urban hospital in West Africa
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Infect Dis 7:2. 2007
    ..Few studies on bacteraemia in Africa have been published. We aimed to prospectively identify the causative organisms of bacteraemia in The Gambia and their relation to clinical diagnoses, outcome and antimicrobial susceptibility...
  57. doi Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia
    Abraham Borer
    Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Infect Control Hosp Epidemiol 30:972-6. 2009
    To determine the attributable (direct) mortality and morbidity caused by carbapenem-resistant Klebsiella pneumoniae bacteremia.
  58. pmc Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients
    Stefanie Kramme
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Clin Microbiol 47:586-9. 2009
    ..In conclusion, proinflammatory cytokines and IL-10 were differentially related to human bacteremia. They may thus be induced by different constituents of O. tsutsugamushi...
  59. pmc Robinsoniella peoriensis bacteremia in a patient with pancreatic cancer
    Dingxia Shen
    Department of Microbiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, People s Republic of China
    J Clin Microbiol 48:3448-50. 2010
    ..We describe here a case of R. peoriensis bacteremia in a 42-year-old male with pancreatic cancer...
  60. ncbi Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients
    A L Oliveira
    Hospital Universitario, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Bone Marrow Transplant 39:775-81. 2007
    The incidence of Gram-negative bacteremia has increased in hematopoietic stem cell transplant (HSCT) recipients...
  61. ncbi Two nations: racial disparities in bloodstream infections recorded at Alice Springs Hospital, central Australia, 2001-2005
    Lloyd J Einsiedel
    Department of Medicine, Alice Springs Hospital, Alice Springs, NT, Australia
    Med J Aust 192:567-71. 2010
    ..To compare bloodstream infection (BSI) rates, pathogens and mortality among Indigenous and non-Indigenous adults in central Australia...
  62. ncbi Significant reductions in methicillin-resistant Staphylococcus aureus bacteraemia and clinical isolates associated with a multisite, hand hygiene culture-change program and subsequent successful statewide roll-out
    M Lindsay Grayson
    Infectious Diseases and Clinical Epidemiology Department, Austin Health, Melbourne, Victoria, Australia
    Med J Aust 188:633-40. 2008
    ..To assess the efficacy of a multimodal, centrally coordinated, multisite hand hygiene culture-change program (HHCCP) for reducing rates of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia and disease in Victorian hospitals...
  63. doi Carbapenem-resistant Klebsiella pneumoniae bacteremia: factors correlated with clinical and microbiologic outcomes
    May Nguyen
    Department of Pharmacy, NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    Diagn Microbiol Infect Dis 67:180-4. 2010
    ..retrospective cohort study describing general outcomes and specific factors associated with positive outcomes in bacteremia due to carbapenem-resistant Klebsiella pneumoniae (CRKP)...
  64. pmc Comparison of genotypes and enterotoxin genes between Staphylococcus aureus isolates from blood and nasal colonizers in a Korean hospital
    Kyong Ran Peck
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 24:585-91. 2009
    ..In particular, the seb and sec genes were detected exclusively in the MRSA isolates of ST5 or spa-CC002, thereby suggesting the co-adaptation of virulence genes with the genetic background and their contribution to biological fitness...
  65. ncbi Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan
    Wen Liang Yu
    Department of Intensive Care Medicine, Chi Mei Medical Center, Yungkang City, Tainan, Taiwan
    Clin Infect Dis 42:1351-8. 2006
    ..However, the association of rmpA with K. pneumoniae clinical syndromes is unreported. We aimed to investigate the clinical correlation between rmpA and primary Klebsiella abscess, focusing on sites other than the liver...
  66. doi Management of Staphylococcus aureus bacteremia and endocarditis: progresses and challenges
    Winfried V Kern
    Center for Infectious Diseases and Travel Medicine, and IFB Center for Chronic Immunodeficiency, University Hospital, and Department of Medicine, Albert Ludwigs University, Freiburg, Germany
    Curr Opin Infect Dis 23:346-58. 2010
    ..aureus is among the leading causes of community-acquired as well as healthcare-associated and hospital-acquired bacteremia and endocarditis...
  67. doi Epidemiology of bacteremia episodes in a single center: increase in Gram-negative isolates, antibiotics resistance, and patient age
    D Marchaim
    Infectious Diseases Unit, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Eur J Clin Microbiol Infect Dis 27:1045-51. 2008
    Increased resistance among isolates causing bacteremia constitutes a major challenge to medical practitioners and institutions. Variability between institutes is substantial, and requires the individual analysis of local trends...
  68. ncbi Inflammatory response and clinical course of adult patients with nosocomial bloodstream infections caused by Candida spp
    H Wisplinghoff
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Clin Microbiol Infect 12:170-7. 2006
    ..Clinical course and mortality in patients with Candida BSI were predicted by systemic inflammatory response and APACHE II score, but not by the infecting species...
  69. pmc Heterogeneous vancomycin-intermediate susceptibility phenotype in bloodstream methicillin-resistant Staphylococcus aureus isolates from an international cohort of patients with infective endocarditis: prevalence, genotype, and clinical significance
    In Gyu Bae
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Infect Dis 200:1355-66. 2009
    ..Using a multinational collection of isolates from methicillin-resistant S. aureus (MRSA) infective endocarditis (IE), we characterized patients with IE with and without hVISA, and we genotyped the infecting strains...
  70. doi Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis
    Christian Theilacker
    Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Germany
    Mol Microbiol 71:1055-69. 2009
    ..In summary, BgsA is a glycosyltransferase synthetizing DGlcDAG, a glycolipid and lipoteichoic acid precursor involved in biofilm accumulation, adherence to host cells, and virulence in vivo...
  71. ncbi Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia
    Daniel K Benjamin
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Perinatol 24:175-80. 2004
    ..To describe survival following nosocomial bloodstream infections and quantify excess mortality associated with positive blood culture...
  72. pmc Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia
    Benjamin P Howden
    Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia
    BMC Microbiol 8:39. 2008
    ..Based on the transcriptome results multiple genes were sequenced and innate immune system stimulation was assessed in the VSSA and hVISA/VISA pairs...
  73. pmc Changing molecular epidemiology of methicillin-resistant Staphylococcus aureus bloodstream isolates from a teaching hospital in Northern Taiwan
    Yhu Chering Huang
    Division of Pediatrics Infectious Diseases, Chang Gung Children s Hospital, Taoyuan, Taiwan
    J Clin Microbiol 44:2268-70. 2006
    ..The changing epidemiology is due to the introduction of a new epidemic clone (sequence type 5) and a local community clone (sequence type 59) of MRSA into the hospital...
  74. doi The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94110, USA
    J Infect Dis 197:1523-30. 2008
    ..SCCmec and ACME in a USA300 clinical isolate to determine the role played by these elements in a rabbit model of bacteremia. We found that deletion of type IV SCCmec did not affect competitive fitness, whereas deletion of ACME ..
  75. pmc Laribacter hongkongensis gen. nov., sp. nov., a novel gram-negative bacterium isolated from a cirrhotic patient with bacteremia and empyema
    K Y Yuen
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 39:4227-32. 2001
    ..nov., sp. nov., is proposed, for which HKU1 is the type strain. Further studies should be performed to ascertain the potential of this bacterium to become an emerging pathogen...
  76. doi Clinical features of heteroresistant vancomycin-intermediate Staphylococcus aureus bacteremia versus those of methicillin-resistant S. aureus bacteremia
    Yasmin Maor
    Infectious Diseases Unit, Tel Aviv University, Sheba Medical Center, Tel Hashomer, Israel
    J Infect Dis 199:619-24. 2009
    ..Our objective was to compare patients who had hVISA bacteremia with patients who had methicillin-resistant S. aureus (MRSA) bacteremia.
  77. ncbi Streptococcus suis in Hong Kong
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diagn Microbiol Infect Dis 57:15-20. 2007
    ..suis strains isolated from pork in this study. These methods may serve as useful tools in studying and enhancing our understanding of these infections in Hong Kong...
  78. doi A sustained hospital outbreak of vancomycin-resistant Enterococcus faecium bacteremia due to emergence of vanB E. faecium sequence type 203
    Paul D R Johnson
    Department of Infectious Diseases and Microbiology, Austin Health, Monash University, Melbourne, Victoria, Australia
    J Infect Dis 202:1278-86. 2010
    A significant increase in the rate of vancomycin-resistant Enterococcus faecium (VREfm) bacteremia at our health service, despite improved infection control, prompted us to investigate the cause.
  79. pmc Proteus mirabilis bloodstream infections: risk factors and treatment outcome related to the expression of extended-spectrum beta-lactamases
    Andrea Endimiani
    Laboratorio di Microbiologia, Ospedale di Circolo e Università dell Insubria, Viale Borri 57, 21100 Varese, Italy
    Antimicrob Agents Chemother 49:2598-605. 2005
    ..mirabilis isolates. Thus, recognition of ESBL-positive strains appears to be critical for the clinical management of patients with systemic P. mirabilis infections...
  80. pmc Association of methicillin-resistant Staphylococcus aureus (MRSA) USA300 genotype with mortality in MRSA bacteremia
    Russell R Kempker
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, 49 Jesse Hill Jr Dr Atlanta, GA 30303, USA
    J Infect 61:372-81. 2010
    To evaluate the association of USA300 genotype with outcomes in persons with MRSA bacteremia and examine the epidemiology of MRSA bacteremia over time.
  81. ncbi Contribution of cell surface protein antigen PAc of Streptococcus mutans to bacteremia
    Kazuhiko Nakano
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    Microbes Infect 8:114-21. 2006
    Streptococcus mutans, a major cariogenic bacterium, is occasionally isolated from the blood of patients with bacteremia and infective endocarditis. Mutant strains of S...
  82. pmc Clinical and molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli causing bacteremia in the Rotterdam Area, Netherlands
    Akke K van der Bij
    1Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, Netherlands
    Antimicrob Agents Chemother 55:3576-8. 2011
    We investigated the clinical and molecular characteristics of bacteremia caused by extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli over a 2-year period (2008 to 2009) in the Rotterdam region (including 1 teaching hospital ..
  83. ncbi The association of Streptococcus bovis bacteremia and gastrointestinal diseases: a retrospective analysis
    Waleed Alazmi
    Division of Gastroenterology, University of Miami Jackson Memorial Medical Center, Miami, Florida 33101, USA
    Dig Dis Sci 51:732-6. 2006
    There is a well-established association between Streptococcus bovis bacteremia (SBB) and colorectal cancer. However, SBB is also frequently associated with chronic liver disease and has been described with other gastrointestinal disorders...
  84. ncbi An intervention to decrease catheter-related bloodstream infections in the ICU
    Peter Pronovost
    School of Medicine, Johns Hopkins University, Baltimore, USA
    N Engl J Med 355:2725-32. 2006
    ..Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal...
  85. doi Streptococcus bovis endocarditis, a silent sign for colonic tumour
    A Gupta
    Department of Surgery, Whittington NHS Trust Hospital, University College London, UK
    Colorectal Dis 12:164-71. 2010
    ..The aim of this article was to review the evidence available in the literature and explore the pathophysiology behind this association...
  86. pmc Serodiversity of opsonic antibodies against Enterococcus faecalis--glycans of the cell wall revisited
    Christian Theilacker
    University Medical Center Freiburg, Freiburg, Germany
    PLoS ONE 6:e17839. 2011
    ..faecalis strains. These cell-wall associated polymers are promising candidates for active and passive vaccination and add to our armamentarium to fight this important nosocomial pathogen...
  87. ncbi Pseudomonas aeruginosa bacteremia: resistance to antibiotics, risk factors, and patient mortality
    Astra Vitkauskiene
    Department of Laboratory Medicine, Kaunas University of Medicine, Eiveniu 2, 50028 Kaunas, Lithuania
    Medicina (Kaunas) 46:490-5. 2010
    The aim of our study was to determine the prevalence of Pseudomonas aeruginosa bacteremia, risk factors, and outcome of patients treated at the Hospital of Kaunas University of Medicine.
  88. doi In vitro activity of tigecycline and comparators on Acinetobacter spp. isolates collected from patients with bacteremia and MIC change during the Tigecycline Evaluation and Surveillance Trial, 2004 to 2008
    Yun F Wayne Wang
    Grady Memorial Hospital, Atlanta, GA 30303, USA
    Diagn Microbiol Infect Dis 68:73-9. 2010
    ..Tigecycline creep was noted between 2004 and 2007, corresponding closely to changes in MIC(90)...
  89. pmc The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice
    Ping Zhang
    Department of Medicine, Section of Pulmonary Critical Care Medicine, LSU Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Stem Cells 26:1778-86. 2008
    ..To investigate the hematopoietic precursor cell response to bacterial infection, bacteremia was established in Balb/c mice by i.v. injection of Escherichia coli...
  90. pmc Vancomycin MIC plus heteroresistance and outcome of methicillin-resistant Staphylococcus aureus bacteremia: trends over 11 years
    Adina C Musta
    Department of Medicine, Infectious Diseases, St John Hospital and Medical Center, Detroit, MI, USA
    J Clin Microbiol 47:1640-4. 2009
    ..6%; P = 0.03). However, the impact of V-MIC and hVISA status on mortality or persistent (> or = 7 days) bacteremia was not substantiated by multivariate analysis...
  91. pmc TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia
    Tobias Strunk
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    PLoS ONE 5:e10111. 2010
    Staphylococcus epidermidis (SE) is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at the extremes of age, motivating study of host clearance mechanisms...
  92. doi Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic
    Sara E Cosgrove
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin Infect Dis 48:713-21. 2009
    ..This study evaluated the association between this practice and nephrotoxicity...
  93. doi Methicillin-resistant Staphylococcus aureus central line-associated bloodstream infections in US intensive care units, 1997-2007
    Deron C Burton
    Surveillance Branch, Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 301:727-36. 2009
    ..Concerns about rates of methicillin-resistant Staphylococcus aureus (MRSA) health care-associated infections have prompted calls for mandatory screening or reporting in efforts to reduce MRSA infections...
  94. pmc Heterogeneity of the humoral immune response following Staphylococcus aureus bacteremia
    N J Verkaik
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 29:509-18. 2010
    ..Here, we present novel insights into the antibody responses following S. aureus bacteremia. Fifteen bacteremic patients were followed extensively from diagnosis onwards (median 29 days, range 9-74). S...
  95. pmc Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus
    Jonas Lannergård
    Microbiology Programme, Department of Cell and Molecular Biology, Box 596, Biomedical Center, Uppsala University, S 75124 Uppsala, Sweden
    Antimicrob Agents Chemother 53:2059-65. 2009
    ..We analyzed a phylogenetically diverse collection of fusidic acid-resistant bacteremia isolates to determine which resistance classes were prevalent and whether these were associated with particular ..
  96. pmc Impact of multidrug-resistant Pseudomonas aeruginosa bacteremia on patient outcomes
    Vincent H Tam
    University of Houston College of Pharmacy, 1441 Moursund Street, Houston, TX 77030, USA
    Antimicrob Agents Chemother 54:3717-22. 2010
    ..aeruginosa bacteremia on patient outcomes. We performed a retrospective cohort study of adult patients with P...
  97. doi Bloodstream infection due to Acinetobacter spp: epidemiology, risk factors and impact of multi-drug resistance
    D W Wareham
    Division of Infection, Barts and The London NHS Trust, London, UK
    Eur J Clin Microbiol Infect Dis 27:607-12. 2008
    ..A descriptive retrospective observational study was undertaken of all episodes of Acinetobacter bacteremia occurring in a UK tertiary care centre from 1998-2006...
  98. doi [Clinical relevance of time-to-positivity in BACTEC9240 blood culture system]
    Sang Hyuk Park
    Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Lab Med 30:276-83. 2010
    ..Continuous monitoring systems have allowed determination of the time-to-positivity (TTP). We evaluated the clinical relevance of TTP in the BACTEC9240 system (Becton-Dickinson, USA)...
  99. doi Clinical outcomes of carbapenem-resistant Acinetobacter baumannii bloodstream infections: study of a 2-state monoclonal outbreak
    L Silvia Munoz-Price
    University of Miami, Miami, FL, USA
    Infect Control Hosp Epidemiol 31:1057-62. 2010
    ..To characterize the clinical outcomes of patients with bloodstream infection caused by carbapenem-resistant Acinetobacter baumannii during a 2-state monoclonal outbreak...
  100. pmc Antibiotic use in Thailand: quantifying impact on blood culture yield and estimates of pneumococcal bacteremia incidence
    Julia Rhodes
    Thailand Ministry of Public Health United States Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand
    Am J Trop Med Hyg 83:301-6. 2010
    ..01). Pre-culture antibiotic use by serum antimicrobial activity reduced pneumococcal bacteremia incidence by 32% overall and 39% in children < 5 years of age...
  101. ncbi Bacteremia in patients with ventilator-associated pneumonia is associated with increased mortality: A study comparing bacteremic vs. nonbacteremic ventilator-associated pneumonia
    Kemal Agbaht
    Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, Institut Pere Virgili, Tarragona, Spain
    Crit Care Med 35:2064-70. 2007
    ..To assess whether bacteremic ventilator-associated pneumonia (B-VAP) differs in terms of risk factors, organisms, and outcomes from nonbacteremic VAP (NB-VAP)...

Research Grants78

  1. LISTERIA AND SHIGELLA USE ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 2010
    The gram positive bacillus Listeria monocytogenes causes bacteremia and meningitis, while the gram negative bacillus Shigella flexneri causes severe diarrhea and dehydration...
  2. Pacific-Southwest Ctr for Biodefense & Emerg Infect Dis*
    Alan Barbour; Fiscal Year: 2007
    ..R.) PROJECT 1 Disseminated anthrax is characterized by both a massive bacteremia and toxemia...
  3. LISTERIA USES HOST CELL ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 1993
    Listeria monocytogenes is an intracellular parasite which causes bacteremia and meningitis in immunocompromised patients. The incidence of listeriosis in AIDS is 100-250 times higher than the normal population...
  4. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2003
    ..Life-threatening complications of bartonellosis can include endocarditis, peliosis hepatis, relapsing bacteremia, encephelopathy and neuroretinitis...
  5. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    ..Life-threatening complications of bartonellosis can include endocarditis, peliosis hepatis, relapsing bacteremia, encephelopathy and neuroretinitis...
  6. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..a diverse spectrum of human and animal diseases, including wound infections, osteomyelitis, endocarditis, and bacteremia leading to secondary abscesses in any of the major organ systems...
  7. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2007
    Staphylococci are the leading cause of hospital-acquired infections, especially nosocomial bacteremia. The two most effective and widely used anti-staphylococcal therapeutic agents are glycopeptides and beta-lactams, both of which target ..
  8. In Vivo Virulence Gene Expression in Acute Otitis Media
    Ha Sheng Li Korotky; Fiscal Year: 2007
    ..otitis media (OM) and responsible for over 1 million infant deaths each year from pneumonia, meningitis, and bacteremia. With the emergence and dissemination of antibiotic resistant pneumococcal strains, coupled to changing patterns ..
  9. LISTERIA AND SHIGELLA USE HOST CELL ACTIN
    Frederick Southwick; Fiscal Year: 2006
    The gram-positive bacillus Listeria monocytogenes predominantly infects immunocompromised patients, causing bacteremia and meningitis while the gram-negative bacillus Shigella flexneri infects normal hosts causing severe diarrhea and ..
  10. CONJUGAL TRANSFER OF BACTEROIDES ANTIBIOTIC RESISTANCES
    Abigail Salyers; Fiscal Year: 1999
    ..genera of bacteria in the human colon and female vaginal tract, is also a common cause of internal abscesses and bacteremia in people with colon cancer or abdominal trauma. Enterotoxin producing strains of B...
  11. INTERACTION OF GROUP A STREP WITH THE PLASMINOGEN SYSTEM
    Michael Boyle; Fiscal Year: 2001
    ..with a variety of diseases including pharyngitis, impetigo, and invasive infections such as cellulitis and bacteremia. Recently, the incidence and severity of streptococcal disease has increased and the exact nature of the ..
  12. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
    ..Chorioamnionitis is a recognized risk factor for bacteremia and septic shock and is associated with a several-fold increase in the risk for cesarean delivery...
  13. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2010
    ..In addition, passive transfer of CP5-EPA antibodies resulted in a 98% reduction in S. aureus bacteremia in mice. These data provide a strong foundation for the proposed studies to determine whether multicomponent S...
  14. PGA antigenemia for early diagnosis of anthrax
    Thomas Kozel; Fiscal Year: 2007
    ..results showed that the initial presence of detectable PGA in blood coincided with the occurrence of detectable bacteremia. Full bacteremia was accompanied by a massive antigenemia with antigen titers as high as 1/5,000,000 48 h after ..
  15. A CDSS to Translate Pressure Ulcer Prediction and Prevention to Home Health Care
    Sandra Bergquist Beringer; Fiscal Year: 2007
    ..in mortality, suffer extreme pain, social isolation and many develop complications such as osteomyelitis or bacteremia that require hospitalization. Overall costs for treatment are $9.1 to $11.6 billion per year...
  16. LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1999
    Circulatory shock and critical organ injury during gram-negative bacteremia (GNB) result from inappropriate regulation of a cytokine network involving tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1alpha, IL-1beta, IL4, and ..
  17. Study of S pneumoniae Virulence Gene Regulation
    Andrew Camilli; Fiscal Year: 2002
    ..goal of our research is to understand the pathogenicity of Streptococcus pneumoniae, the most common cause of bacteremia, bacterial meningitis, otitis media and community-acquired pneumonia in the U.S.A...
  18. Role of phase-variable DNA methylase in virulence of Haemophilus influenzae
    Arnold Smith; Fiscal Year: 2007
    ..of the upper respiratory tract, such as otitis media and bronchitis, and of systemic infections, such as bacteremia and meningitis. Ideally, prevention or treatment of H...
  19. Physiology and Cloning of B. Fragilis Enterotoxin
    CYNTHIA SEARS; Fiscal Year: 2005
    Bacteroides fragillis are the leading causes of anaerobic bacteremia and intraabdominal abscesses. Certain strains of B. fragilis termed enterotoxigenic B...
  20. Biomechanics of Blood Stream Infections
    JOHN YOUNGER; Fiscal Year: 2009
    Intravascular device-related blood stream infection is the leading cause of bacteremia in the United States and is a common and life threatening complication among ill and injured patients...
  21. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    Group B streptococcus is the predominant etiological agent of neonatal bacteremia, sepsis and meningitis, and has been correlated with preterm membrane rupture and premature birth...