bacteremia

Summary

Summary: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.

Top Publications

  1. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
  2. ncbi Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
  3. pmc Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
    J Anthony G Scott
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya org
    Lancet 378:1316-23. 2011
  4. ncbi Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group
    C von Eiff
    Institute of Medical Microbiology, University of Munster, Germany
    N Engl J Med 344:11-6. 2001
  5. pmc Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis
    Elizabeth A Reddy
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lancet Infect Dis 10:417-32. 2010
  6. ncbi Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections
    N Deborah Friedman
    Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
    Ann Intern Med 137:791-7. 2002
  7. ncbi Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
    Sara E Cosgrove
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 36:53-9. 2003
  8. ncbi Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
    Ulrich Seybold
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Clin Infect Dis 42:647-56. 2006
  9. ncbi Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome
    Rachel N Bronzan
    Blantyre Malaria Project, Blantyre, Malawi
    J Infect Dis 195:895-904. 2007
  10. pmc Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe
    Marlieke E A de Kraker
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS Med 8:e1001104. 2011

Detail Information

Publications307 found, 100 shown here

  1. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  2. ncbi Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
    ..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia.
  3. pmc Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
    J Anthony G Scott
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya org
    Lancet 378:1316-23. 2011
    ..Many investigators have suggested that malaria infection predisposes individuals to bacteraemia. We tested this hypothesis with mendelian randomisation studies of children with the malaria-protective phenotype of sickle-cell trait (HbAS)...
  4. ncbi Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group
    C von Eiff
    Institute of Medical Microbiology, University of Munster, Germany
    N Engl J Med 344:11-6. 2001
    ..We examined S. aureus isolates from blood and from nasal specimens to determine whether the organisms in the bloodstream originated from the patient's own flora...
  5. pmc Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis
    Elizabeth A Reddy
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lancet Infect Dis 10:417-32. 2010
    ..Improved clinical microbiology services and reassessment of empirical treatment guidelines that account for the epidemiology of bloodstream infections might contribute to better outcomes...
  6. ncbi Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections
    N Deborah Friedman
    Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
    Ann Intern Med 137:791-7. 2002
    ..Bloodstream infections occurring in persons residing in the community, regardless of whether those persons have been receiving health care in an outpatient facility, have traditionally been categorized as community-acquired infections...
  7. ncbi Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
    Sara E Cosgrove
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 36:53-9. 2003
    ..was performed to summarize the impact of methicillin-resistance on mortality in Staphylococcus aureus bacteremia. A search of the MEDLINE database for studies published during the period of 1 January 1980 through 31 December ..
  8. ncbi Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
    Ulrich Seybold
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Clin Infect Dis 42:647-56. 2006
    ..Whether community-associated methicillin-resistant Staphylococcus aureus (MRSA) genotypes (e.g., USA300) are a major cause of bloodstream infections (BSIs) and health care-associated infections has been poorly defined...
  9. ncbi Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome
    Rachel N Bronzan
    Blantyre Malaria Project, Blantyre, Malawi
    J Infect Dis 195:895-904. 2007
    Previous prospective studies of bacteremia in African children with severe malaria have mainly included children with cerebral malaria, and no study has examined the impact of human immunodeficiency virus (HIV) infection...
  10. pmc Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe
    Marlieke E A de Kraker
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS Med 8:e1001104. 2011
    ....
  11. ncbi Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?
    Kyle J Popovich
    Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 46:787-94. 2008
    ..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
  12. pmc Clinical outcomes of type III Pseudomonas aeruginosa bacteremia
    Ali A El-Solh
    Veterans Affairs Western New York Healthcare System, Western New York Respiratory Research Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Buffalo, NY, USA
    Crit Care Med 40:1157-63. 2012
    Pseudomonas aeruginosa bacteremia is a serious and life-threatening infection associated with high mortality. Among the multitude of virulence determinants possessed by P...
  13. ncbi Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia
    Warren E Rose
    School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA
    J Infect Dis 206:1604-11. 2012
    Staphylococcus aureus bacteremia (SaB) carries considerable morbidity and mortality...
  14. ncbi Community-acquired bacteremia among children admitted to a rural hospital in Mozambique
    Betuel Sigauque
    Centro de Investigação em Saúde da Manhiça, Maputo, Mozambique
    Pediatr Infect Dis J 28:108-13. 2009
    Although community-acquired bacteremia is an important cause of childhood mortality in Africa, recognition of disease burden and potential impact of bacterial vaccines is limited.
  15. ncbi Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein
    Vance G Fowler
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 190:1140-9. 2004
    The causes of persistent bacteremia (PB) due to methicillin-resistant Staphylococcus aureus (MRSA) are poorly understood...
  16. ncbi Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica Serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Clin Infect Dis 46:963-9. 2008
    Nontyphoidal salmonellae (NTS) have become the most common cause of bacteremia in tropical Africa, particularly among susceptible children and HIV-infected adults.
  17. pmc Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis
    Christian Østergaard
    Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev, Denmark
    BMC Infect Dis 10:1. 2010
    b>Bacteremia and systemic complications both play important roles in brain pathophysiological alterations and the outcome of pneumococcal meningitis...
  18. ncbi Prospective study of prognostic factors in community-acquired bacteremic pneumococcal disease in 5 countries
    M Kalin
    Department of Medicine, Section of Infectious Diseases, Karolinska Hospital, 171 76 Stockholm, Sweden
    J Infect Dis 182:840-7. 2000
    To define the influence of prognostic factors in patients with community-acquired pneumococcal bacteremia, a 2-year prospective study was performed in 5 centers in Canada, the United States, the United Kingdom, Spain, and Sweden...
  19. ncbi Temporal changes in the incidence and 30-day mortality associated with bacteremia in hospitalized patients from 1992 through 2006: a population-based cohort study
    Mette Søgaard
    Department of Clinical Microbiology, Aarhus University Hospital, Aalborg, Denmark
    Clin Infect Dis 52:61-9. 2011
    Little is known about temporal trends in the incidence and mortality associated with bacteremia in the general population.
  20. pmc Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia
    Anne L M Vlek
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e32589. 2012
    ..culture broths can reduce the turnaround time to identification and may lead to earlier appropriate treatment of bacteremia. During February and April 2010, direct MALDI-TOF MS was routinely performed on all positive blood cultures...
  21. pmc Novel structurally designed vaccine for S. aureus α-hemolysin: protection against bacteremia and pneumonia
    Rajan P Adhikari
    Integrated Biotherapeutics Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 7:e38567. 2012
    ..This vaccine candidate, denoted AT-62aa, was tested in pneumonia and bacteremia infection models using S. aureus strain Newman and the pandemic strain USA300 (LAC)...
  22. pmc Differing burden and epidemiology of non-Typhi Salmonella bacteremia in rural and urban Kenya, 2006-2009
    Collins Tabu
    Field Epidemiology and Laboratory Training Program, Nairobi, Kenya
    PLoS ONE 7:e31237. 2012
    The epidemiology of non-Typhi Salmonella (NTS) bacteremia in Africa will likely evolve as potential co-factors, such as HIV, malaria, and urbanization, also change.
  23. pmc Risk factors and prognosis of nosocomial bloodstream infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli
    Jesús Rodríguez-Baño
    Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, and Departamento de Medicina, Universidad de Seville, Avda Dr Fedriani, 3, Seville 41009, Spain
    J Clin Microbiol 48:1726-31. 2010
    ..The previous use of oxyimino-beta-lactams was the only modifiable risk factor found. Resistance to drugs other than penicillins and cephalosporins was associated with increased mortality...
  24. ncbi Influence of genospecies of Acinetobacter baumannii complex on clinical outcomes of patients with acinetobacter bacteremia
    Yu Chung Chuang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 52:352-60. 2011
    ..baumannii (genospecies 2) from other genospecies. Genospecies typing offers a potential tool to determine whether there are major differences in pathogenicity among the genospecies...
  25. ncbi Community-onset bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli: risk factors and prognosis
    Jesús Rodríguez-Baño
    Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Seville, Spain
    Clin Infect Dis 50:40-8. 2010
    ..We investigated the prevalence and risk factors for COBSI due to ESBLEC, and described their clinical features and the impact of COBSI caused by ESBLEC on 14-day mortality...
  26. pmc Intensity of rainfall and severity of melioidosis, Australia
    Bart J Currie
    Menzies School of Health Research and Flinders University, Darwin, Northern Territory, Australia
    Emerg Infect Dis 9:1538-42. 2003
    ..70 [confidence interval [CI] 1.09 to 2.65]), bacteremia (OR 1.93 [CI 1.24 to 3.02]), septic shock (OR 1.94 [CI 1.14 to 3.29]), and death (OR 2.50 [CI 1.36 to 4.57])...
  27. ncbi Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000-2006
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Infect Dis 198:336-43. 2008
    ..We sought to describe the epidemiological profile of S. aureus bacteremia and to assess whether the incidence and severity of and the antimicrobial resistance rates associated with this ..
  28. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
    ..However, the relationship between the clinical presentation and bacterial factors remains unclear. The aim of this study was to investigate the clinical features of patients and the serotype and ribotype of K pneumoniae liver abscess...
  29. pmc Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis
    Nele Wellinghausen
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Ulm, Albert Einstein Allee 23, D 89081 Ulm, Germany
    J Clin Microbiol 47:2759-65. 2009
    ..sepsis, or neutropenic fever, a new commercial PCR test (SepsiTest; Molzym) was evaluated for rapid diagnosis of bacteremia. The test comprises a universal PCR from the 16S rRNA gene, with subsequent identification of bacteria from ..
  30. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target...
  31. ncbi An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia
    Karri A Bauer
    Department of Pharmacy, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Clin Infect Dis 51:1074-80. 2010
    Rapid organism detection of Staphylococcus aureus bacteremia and communication to clinicians expedites antibiotic optimization. We evaluated clinical and economic outcomes of a rapid polymerase chain reaction methicillin‐resistant S...
  32. ncbi Pediatric and neonatal Staphylococcus aureus bacteremia: epidemiology, risk factors, and outcome
    Robert E Burke
    Department of Internal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 30:636-44. 2009
    ..To evaluate the impact of methicillin-resistant Staphylococcus aureus on the prevalence of S. aureus bloodstream infection among children...
  33. pmc Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study
    Longxiang Su
    Department of Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan Province 572013, China
    BMC Infect Dis 12:157. 2012
    ..expressed on myeloid cells 1 (sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) serum levels for differentiating sepsis from SIRS, identifying new fever caused by bacteremia, and assessing prognosis when new fever occurred.
  34. ncbi Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia
    Angela M Huang
    Departments of Pharmacy Services
    Clin Infect Dis 57:1237-45. 2013
    ..The objective of this study was to assess the impact of this combined approach on clinical and antimicrobial therapy-related outcomes in patients with bloodstream infections...
  35. pmc Bacteremia in Kenyan children presenting with malaria
    T Were
    University of New Mexico Kenya Medical Research Institute, Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kisumu, Kenya
    J Clin Microbiol 49:671-6. 2011
    Since the etiologies and clinical outcomes of bacteremia in children with Plasmodium falciparum infections, particularly in areas of holoendemic malaria transmission, are largely unexplored, blood cultures and comprehensive clinical, ..
  36. ncbi Periodontal bacteremia and various vascular diseases
    T Iwai
    Tsukuba Vascular Center and Buerger Disease Research Institute, Tatsuzawa, Moriya city, Japan
    J Periodontal Res 44:689-94. 2009
    ..Serum titer levels of each bacterium are now available and have shown a significant relationship between severity and individual differences...
  37. pmc Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections
    Victor L Yu
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Emerg Infect Dis 13:986-93. 2007
    We studied 455 consecutive episodes of Klebsiella pneumoniae bacteremia occurring in 7 countries...
  38. pmc LysGH15, a novel bacteriophage lysin, protects a murine bacteremia model efficiently against lethal methicillin-resistant Staphylococcus aureus infection
    Jingmin Gu
    College of Animal Science and Veterinary Medicine, Jilin University, Xi an Road 5333, Changchun 130062, People s Republic of China
    J Clin Microbiol 49:111-7. 2011
    ..01). Bacteremia in unprotected mice reached colony counts of about 10(7) CFU/ml within 3...
  39. pmc Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation
    Ying Taur
    Infectious Disease Service, Department of Medicine, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Clin Infect Dis 55:905-14. 2012
    b>Bacteremia is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It is unclear whether changes in the intestinal microbiota during allo-HSCT contribute to the development of bacteremia...
  40. pmc Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns
    Wen Chien Ko
    National Cheng Kung University Medical College, Taiwan
    Emerg Infect Dis 8:160-6. 2002
    We initiated a worldwide collaborative study, including 455 episodes of bacteremia, to elucidate the clinical patterns of Klebsiella pneumoniae. Historically, community-acquired pneumonia has been consistently associated with K...
  41. ncbi Bacteremia due to periodontal probing: a clinical and microbiological investigation
    C G Daly
    Discipline of Periodontics, University of Sydney, Australia
    J Periodontol 72:210-4. 2001
    Infective endocarditis can occur in susceptible individuals due to bacteremia of oral origin. The aim of this study was to investigate the occurrence of bacteremia caused by full mouth periodontal probing.
  42. ncbi Nontyphoidal salmonellosis
    E L Hohmann
    Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 32:263-9. 2001
    Nontyphoidal Salmonella are important foodborne pathogens that cause gastroenteritis, bacteremia, and subsequent focal infection...
  43. ncbi Clinical impact of fluoroquinolone prophylaxis in neutropenic patients with hematological malignancies
    Yong Chong
    Department of Blood and Marrow Transplantation, Hara Sanshin Hospital, 1 8, Taihaku cho Hakata ku, Fukuoka, 812 0033, Japan
    Int J Infect Dis 15:e277-81. 2011
    ..This study assessed the effect of discontinuing quinolone prophylaxis on the etiology and the resistance pattern of blood culture isolates and on the prognosis among febrile neutropenic patients receiving chemotherapy...
  44. ncbi Emergence of extended-spectrum β-lactamase-producing escherichia coli as a cause of community-onset bacteremia in South Korea: risk factors and clinical outcomes
    Sun Hee Park
    Division of Infectious Disease, Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea
    Microb Drug Resist 17:537-44. 2011
    To define the risk factors and clinical outcomes of community-onset bacteremia caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBLEC), we analyzed 50 consecutive cases of community-onset bacteremia caused by ..
  45. ncbi Age- and sex-associated trends in bloodstream infection: a population-based study in Olmsted County, Minnesota
    Daniel Z Uslan
    Divisions of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Arch Intern Med 167:834-9. 2007
    ..Despite increasing concerns about antimicrobial resistance and emerging pathogens among blood culture isolates, contemporary population-based data on the age- and sex-specific incidence of bloodstream infections (BSIs) are limited...
  46. ncbi Bacteraemia complicating severe malaria in children
    J Berkley
    Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Trans R Soc Trop Med Hyg 93:283-6. 1999
    ..We recommend that young children with severe malaria be treated with broad-spectrum antibiotics in addition to antimalarial drugs...
  47. pmc Microbiology of odontogenic bacteremia: beyond endocarditis
    N B Parahitiyawa
    Faculty of Dentistry, Oral Bio Sciences, The University of Hong Kong, Hong Kong SAR
    Clin Microbiol Rev 22:46-64, Table of Contents. 2009
    ..The nature of the infective agents and end organ infections (other than endocarditis) is also described, with an emphasis on the challenge of establishing the link between odontogenic infections and related systemic, focal infections...
  48. ncbi Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia
    Ki Tae Kwon
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Seoul 135 710, Korea
    J Antimicrob Chemother 59:525-30. 2007
    ..To investigate the impact of imipenem resistance on the mortality rate among patients with Acinetobacter bacteraemia...
  49. ncbi Non-typhoidal salmonella bacteraemia among HIV-infected Malawian adults: high mortality and frequent recrudescence
    Melita A Gordon
    Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi
    AIDS 16:1633-41. 2002
    ..We aimed to describe the presentation and outcome of NTS bacteraemia, the pattern of recurrence, and to determine whether recurrence results from re-infection or recrudescence...
  50. ncbi Pseudomonas aeruginosa bacteremia: risk factors for mortality and influence of delayed receipt of effective antimicrobial therapy on clinical outcome
    Cheol In Kang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Clin Infect Dis 37:745-51. 2003
    ..Data on 136 patients with P. aeruginosa bacteremia were retrospectively analyzed to evaluate risk factors for mortality...
  51. ncbi Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States
    Hilmar Wisplinghoff
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany
    Clin Infect Dis 36:1103-10. 2003
    ..The source of BSI was not determined for 57% of patients. The crude mortality rate was 36% for neutropenic patients and 31% for nonneutropenic patients...
  52. pmc Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study
    Bjørn Blomberg
    Department of Medicine, Haukeland University Hospital, Bergen, Norway
    BMC Infect Dis 7:43. 2007
    ..Bloodstream infection is a common cause of hospitalization, morbidity and death in children. The impact of antimicrobial resistance and HIV infection on outcome is not firmly established...
  53. pmc The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Invest 118:1553-62. 2008
    Nontyphoidal strains of Salmonella (NTS) are a common cause of bacteremia among African children. Cell-mediated immune responses control intracellular infection, but they do not protect against extracellular growth of NTS in the blood...
  54. ncbi Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 60:913-20. 2007
    ..We performed a systematic review and meta-analysis to examine the impact of extended-spectrum beta-lactamase (ESBL) production on mortality and delay in effective therapy in Enterobacteriaceae bacteraemia...
  55. ncbi Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation
    Lone Forner
    Department of Periodontology, University of Copenhagen, Copenhagen, Denmark
    J Clin Periodontol 33:401-7. 2006
    SCIENTIFIC RATIONALE FOR STUDY: Bacteremia occurs with various frequency after oral procedures. Periodontal disease may affect the incidence, magnitude, duration and bacterial spectrum of bacteremia...
  56. pmc Invasive salmonellosis among children admitted to a rural Tanzanian hospital and a comparison with previous studies
    George Mtove
    National Institute for Medical Research Amani Centre, Tanga, Tanzania
    PLoS ONE 5:e9244. 2010
    ..We compared our main findings with those from previous studies among children in sub-Saharan Africa...
  57. ncbi Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    J Antimicrob Chemother 65:2658-65. 2010
    ....
  58. pmc Epidemiology and outcome of Klebsiella species bloodstream infection: a population-based study
    Majdi N Al-Hasan
    Department of Medicine, University of Kentucky Chandler Medical Center, 800 Rose St, Room MN 672, Lexington, KY 40536, USA
    Mayo Clin Proc 85:139-44. 2010
    ..To determine incidence rate, seasonal variation, and short- and long-term outcomes of Klebsiella species bloodstream infection (BSI) in a population-based setting...
  59. ncbi Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia
    Nam Su Ku
    Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
    Shock 38:123-7. 2012
    ..However, to our knowledge, little is known about RDW as a predictor of mortality in patients with Gram-negative bacteremia, a major nosocomial cause of intra-abdominal infections, urinary tract infections, and primary bacteremia...
  60. pmc Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
    Cornelis P C de Jager
    Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, Tolbrugstraat 11, 5200 ME s Hertogenbosch, The Netherlands
    Crit Care 14:R192. 2010
    Absolute lymphocytopenia has been reported as a predictor of bacteremia in medical emergencies...
  61. ncbi A systematic review of the methods used to assess the association between appropriate antibiotic therapy and mortality in bacteremic patients
    Jessina C McGregor
    Oregon State University College of Pharmacy, Portland, OR 97239, USA
    Clin Infect Dis 45:329-37. 2007
    ..In brief, future studies should define "inappropriate" therapy on the basis of in vitro susceptibility data, should separately evaluate empiric and definitive therapy, and should control for the baseline severity of illness...
  62. ncbi Diagnostic accuracy of soluble urokinase plasminogen activator receptor (suPAR) for prediction of bacteremia in patients with systemic inflammatory response syndrome
    Martin Hoenigl
    Section of Infectious Diseases, Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 20, 8036 Graz, Austria
    Clin Biochem 46:225-9. 2013
    ..In this study, the diagnostic accuracy of suPAR, C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) to predict bacteremia in patients with systemic inflammatory response syndrome (SIRS) was compared.
  63. ncbi Mortality of S. aureus bacteremia and infectious diseases specialist consultation--a study of 521 patients in Germany
    Siegbert Rieg
    Department of Medicine, Center for Infectious Diseases and Travel Medicine, University Medical Center Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    J Infect 59:232-9. 2009
    ..To evaluate the relationship between mortality of bloodstream infection due to Staphylococcus aureus and infectious diseases specialist consultation and other factors potentially associated with outcomes...
  64. ncbi Illness severity in community-onset invasive Staphylococcus aureus infection and the presence of virulence genes
    Michael C Wehrhahn
    Department of Microbiology and Infectious Diseases, Royal Perth Hospital and PathWest Laboratory Medicine, WA
    J Infect Dis 205:1840-8. 2012
    ..It is uncertain whether particular clones causing invasive community-onset methicillin-resistant and methicillin-sensitive Staphylococcus aureus (cMRSA/cMSSA) infection differ in virulence...
  65. pmc Bacteremia is an independent risk factor for mortality in nosocomial pneumonia: a prospective and observational multicenter study
    Monica Magret
    Critical Care Department, Vall d Hebron University Hospital, CibeRes, VHIR, Universitat Autonoma de Barcelona, Vall d Hebron St, Barcelona 08035, Spain
    Crit Care 15:R62. 2011
    ..Studies on bacteremia associated with hospital-acquired pneumonia (HAP) have reported fatality rates of up to 50%...
  66. ncbi A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples
    Lutz Eric Lehmann
    Klinik und Poliklinik für Anästhesie und Operative Intensivmedizin, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Med Microbiol Immunol 197:313-24. 2008
    ..8%. The analytical specificity in 102 healthy blood donors was 100%. Although further evaluation is warranted, our assay holds promise for more rapid pathogen identification in clinical sepsis...
  67. pmc Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome
    Cheol In Kang
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 744, Republic of Korea
    Antimicrob Agents Chemother 49:760-6. 2005
    ..initial antimicrobial therapy on survival, a total of 286 patients with antibiotic-resistant gram-negative bacteremia, 61 patients with Escherichia coli bacteremia, 65 with Klebsiella pneumoniae bacteremia, 74 with Pseudomonas ..
  68. pmc Influence of multidrug resistance and appropriate empirical therapy on the 30-day mortality rate of Pseudomonas aeruginosa bacteremia
    Laura Morata
    Departments of Infectious Diseases, Hospital Clinic of Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 56:4833-7. 2012
    ..influences of appropriate empirical antibiotic therapy and multidrug resistance on mortality in patients with bacteremia due to P. aeruginosa (PAB). Episodes of PAB were prospectively registered from 2000 to 2008...
  69. pmc Incidence and characteristics of bacteremia among children in rural Ghana
    Maja Verena Nielsen
    Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS ONE 7:e44063. 2012
    ..1%; n = 22) and Salmonella ser. Typhi (7.0%; n = 17). Yearly cumulative incidence of bacteremia was 46.6 cases/1,000 (CI 40.9-52.2)...
  70. ncbi Salmonella infections in immunocompromised adults
    Melita A Gordon
    Division of Gastroenterology, Henry Wellcome Laboratories, Nuffield Building, Crown Street, Liverpool University L69 3GE, UK
    J Infect 56:413-22. 2008
    ..This review will describe the presentation and pathogenesis of NTS in different categories of immunocompromised adults, contrasted to typhoid fever...
  71. pmc Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
    Anna Krasnodembskaya
    Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012
    ..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis...
  72. ncbi Severe bloodstream infections: a population-based assessment
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    Crit Care Med 32:992-7. 2004
    ..We sought to define the incidence and microbiology of severe bloodstream infection (bloodstream infection associated with intensive care unit admission within 48 hrs) and assess risk factors for acquisition and death...
  73. ncbi β-Lactam/β-lactam inhibitor combinations for the treatment of bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli: a post hoc analysis of prospective cohorts
    Jesús Rodríguez-Baño
    Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Spain
    Clin Infect Dis 54:167-74. 2012
    ..Alternatives to carbapenems--considered the drugs of choice--are needed because of the emergence of carbapenemase-producing enterobacteria. The efficacy of ß-lactam/ß-lactam inhibitors (BLBLI) in such infections is controversial...
  74. ncbi Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:2588-95. 2006
    ..To gain a better understanding of the epidemiology, microbiology, and outcomes of early-onset, culture-positive, community-acquired, healthcare-associated, and hospital-acquired bloodstream infections...
  75. ncbi Comparison of CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae isolates from patients with bacteremia
    Juyoun Shin
    Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Jangan ku, Suwon 440 746, South Korea
    J Infect 63:39-47. 2011
    ..coli and K. pneumoniae isolates that had been more prevalent before the recent increase of CTX-M-15 in Korea...
  76. ncbi Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection
    Ren Wen Tsay
    Division of Infectious Diseases and Tropical Medicine, Tri Service General Hospital, No 325, Section 2, Cheng Kung Road, Neihu, 114 Taipei, Taiwan
    Arch Intern Med 162:1021-7. 2002
    ..Although several epidemiological surveys of Klebsiella clinical isolates have been performed, few studies have correlated the clinical isolate with disease...
  77. pmc A decline in the incidence of invasive non-typhoidal Salmonella infection in The Gambia temporally associated with a decline in malaria infection
    Grant Mackenzie
    Medical Research Council United Kingdom The Gambia, Fajara, The Gambia
    PLoS ONE 5:e10568. 2010
    ..Malaria is a risk factor for invasive non-typhoidal Salmonella (NTS) infection in children. In the last 10 years, indices of malaria infection in The Gambia have fallen substantially...
  78. ncbi Bacillus cereus bacteremia outbreak due to contaminated hospital linens
    T Sasahara
    Department of Infection and Immunity, School of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, 329 0498, Japan
    Eur J Clin Microbiol Infect Dis 30:219-26. 2011
    We describe an outbreak of Bacillus cereus bacteremia that occurred at Jichi Medical University Hospital in 2006. This study aimed to identify the source of this outbreak and to implement appropriate control measures...
  79. ncbi Salvage treatment for persistent methicillin-resistant Staphylococcus aureus bacteremia: efficacy of linezolid with or without carbapenem
    Hee Chang Jang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Clin Infect Dis 49:395-401. 2009
    Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high mortality rates, but no treatment strategy has yet been established...
  80. ncbi Bartonella spp. bacteremia in high-risk immunocompetent patients
    Ricardo G Maggi
    Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Diagn Microbiol Infect Dis 71:430-7. 2011
    ..0%), were screened for antibodies by indirect immunofluorescence assays and for bacteremia using the BAPGM (Bartonella alpha Proteobacteria growth medium) platform...
  81. pmc Neurodevelopment of extremely preterm infants who had necrotizing enterocolitis with or without late bacteremia
    Camilia R Martin
    Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA
    J Pediatr 157:751-6.e1. 2010
    To evaluate neurodevelopment after necrotizing enterocolitis (NEC) and late bacteremia, alone and together.
  82. ncbi An outbreak in an intensive care unit of a strain of methicillin-resistant Staphylococcus aureus sequence type 239 associated with an increased rate of vascular access device-related bacteremia
    Jonathan D Edgeworth
    Department of Infection, Guy s and St Thomas National Health Service Foundation Trust, St Thomas Hospitals, London, SE1 7EH, UK
    Clin Infect Dis 44:493-501. 2007
    ..Patients in intensive care units are at high risk of developing methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. We report an epidemiological and bacterial genomic analysis of a 2-year outbreak in an intensive care unit of a ..
  83. pmc Molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli isolates causing bacteremia in the Calgary Health Region from 2000 to 2007: emergence of clone ST131 as a cause of community-acquired infections
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, 9, 3535 Research Road NW, Calgary, Alberta, Canada
    Antimicrob Agents Chemother 53:2846-51. 2009
    ..was designed to characterize extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli isolates causing bacteremia over an 8-year period (2000 to 2007) in a large well-defined geographical region...
  84. pmc Relation between lymphopenia and bacteraemia in UK adults with medical emergencies
    D H Wyllie
    Nuffield Departments of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 57:950-5. 2004
    ..To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia...
  85. ncbi Prevalence, duration and aetiology of bacteraemia following dental extractions
    I Tomas
    Department of Special Needs, School of Medicine and Dentistry, Santiago de Compostela University, Santiago de Compostela, and Research Laboratory, Department of Clinical Microbiology, Xeral Cies Hospital, Vigo, Spain
    Oral Dis 13:56-62. 2007
    ..To investigate the prevalence, duration and aetiology of bacteraemia following dental extractions, analysing the factors affecting its development...
  86. pmc Bacteremic typhoid fever in children in an urban slum, Bangladesh
    W Abdullah Brooks
    ICDDR, B Centre for Health and Population Research, Mohakhali, Dhaka 1000, Bangladesh
    Emerg Infect Dis 11:326-9. 2005
    ..The relative risk for preschool children compared with older persons was 8.9. Our regression model showed that these children were clinically ill, which suggests a role for preschool immunization...
  87. ncbi Bacteraemia following periodontal procedures
    Denis F Kinane
    University of Louisville School of Dentistry, Louisville, KY 40292, USA
    J Clin Periodontol 32:708-13. 2005
    ..These systemic conditions could be initiated or detrimentally influenced by the repeated entry of bacteria into the bloodstream...
  88. pmc Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment
    Mario Tumbarello
    Istituto Malattie Infettive, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Antimicrob Agents Chemother 51:1987-94. 2007
    ..Prompt initiation of effective antimicrobial treatment is essential in patients with ESBL-BSI, and empirical decisions must be based on a sound knowledge of the local distribution of pathogens and their susceptibility patterns...
  89. ncbi Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection
    Vance G Fowler
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 196:738-47. 2007
    ..The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear...
  90. ncbi Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia
    Abraham Borer
    Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Infect Control Hosp Epidemiol 30:972-6. 2009
    To determine the attributable (direct) mortality and morbidity caused by carbapenem-resistant Klebsiella pneumoniae bacteremia.
  91. pmc Bacteraemia in patients admitted to an urban hospital in West Africa
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Infect Dis 7:2. 2007
    ..Few studies on bacteraemia in Africa have been published. We aimed to prospectively identify the causative organisms of bacteraemia in The Gambia and their relation to clinical diagnoses, outcome and antimicrobial susceptibility...
  92. ncbi Screening for extended-spectrum beta-lactamase-producing Enterobacteriaceae among high-risk patients and rates of subsequent bacteremia
    P Reddy
    Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 45:846-52. 2007
    ..However, the role of routine inpatient surveillance for ESBL colonization in predicting related infection is unclear...
  93. pmc Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients
    Stefanie Kramme
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Clin Microbiol 47:586-9. 2009
    ..In conclusion, proinflammatory cytokines and IL-10 were differentially related to human bacteremia. They may thus be induced by different constituents of O. tsutsugamushi...
  94. ncbi Two nations: racial disparities in bloodstream infections recorded at Alice Springs Hospital, central Australia, 2001-2005
    Lloyd J Einsiedel
    Department of Medicine, Alice Springs Hospital, Alice Springs, NT, Australia
    Med J Aust 192:567-71. 2010
    ..To compare bloodstream infection (BSI) rates, pathogens and mortality among Indigenous and non-Indigenous adults in central Australia...
  95. ncbi Carbapenem-resistant Klebsiella pneumoniae bacteremia: factors correlated with clinical and microbiologic outcomes
    May Nguyen
    Department of Pharmacy, NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    Diagn Microbiol Infect Dis 67:180-4. 2010
    ..retrospective cohort study describing general outcomes and specific factors associated with positive outcomes in bacteremia due to carbapenem-resistant Klebsiella pneumoniae (CRKP)...
  96. ncbi Significant reductions in methicillin-resistant Staphylococcus aureus bacteraemia and clinical isolates associated with a multisite, hand hygiene culture-change program and subsequent successful statewide roll-out
    M Lindsay Grayson
    Infectious Diseases and Clinical Epidemiology Department, Austin Health, Melbourne, Victoria, Australia
    Med J Aust 188:633-40. 2008
    ..To assess the efficacy of a multimodal, centrally coordinated, multisite hand hygiene culture-change program (HHCCP) for reducing rates of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia and disease in Victorian hospitals...
  97. ncbi Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients
    A L Oliveira
    Hospital Universitario, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Bone Marrow Transplant 39:775-81. 2007
    The incidence of Gram-negative bacteremia has increased in hematopoietic stem cell transplant (HSCT) recipients...
  98. pmc Robinsoniella peoriensis bacteremia in a patient with pancreatic cancer
    Dingxia Shen
    Department of Microbiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, People s Republic of China
    J Clin Microbiol 48:3448-50. 2010
    ..We describe here a case of R. peoriensis bacteremia in a 42-year-old male with pancreatic cancer...
  99. ncbi Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan
    Wen Liang Yu
    Department of Intensive Care Medicine, Chi Mei Medical Center, Yungkang City, Tainan, Taiwan
    Clin Infect Dis 42:1351-8. 2006
    ..However, the association of rmpA with K. pneumoniae clinical syndromes is unreported. We aimed to investigate the clinical correlation between rmpA and primary Klebsiella abscess, focusing on sites other than the liver...
  100. ncbi Inflammatory response and clinical course of adult patients with nosocomial bloodstream infections caused by Candida spp
    H Wisplinghoff
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Clin Microbiol Infect 12:170-7. 2006
    ..Clinical course and mortality in patients with Candida BSI were predicted by systemic inflammatory response and APACHE II score, but not by the infecting species...
  101. ncbi Management of Staphylococcus aureus bacteremia and endocarditis: progresses and challenges
    Winfried V Kern
    Center for Infectious Diseases and Travel Medicine, and IFB Center for Chronic Immunodeficiency, University Hospital, and Department of Medicine, Albert Ludwigs University, Freiburg, Germany
    Curr Opin Infect Dis 23:346-58. 2010
    ..aureus is among the leading causes of community-acquired as well as healthcare-associated and hospital-acquired bacteremia and endocarditis...

Research Grants74

  1. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..In addition, some strains invade the bloodstream, causing bacteremia and meningitis. The mechanisms that H...
  2. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..NIs) due to abnormal bacterial invasion of neonatal intestinal epithelia and consequently to limit systemic bacteremia and necrotizing enterocolitis (NEC)...
  3. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..In addition, passive transfer of CP5-EPA antibodies resulted in a 98% reduction in S. aureus bacteremia in mice. These data provide a strong foundation for the proposed studies to determine whether multicomponent S...
  4. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..important infections that cause a wide variety of maladies including pneumonia, skin and wound infections, bacteremia and meningitis. In addition, A...
  5. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..gt;90% at 28 days, 100% long term) leading to complications such as cystitis, pyelonephritis, gram-negative bacteremia, prostatitis, epididymitis, urosepsis, septicemia, orchitis, endocarditis, vertebral osteomyelitis, septic ..
  6. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..Acinetobacter, and Stenotrophomonas, which are prevalent in severe nosocomial infections, such as pneumonia, bacteremia and urinary tract infections...
  7. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    ..microbial response during sepsis, 2) elucidate the mechanism responsible for the protective role of HO-1 against bacteremia, and 3) further investigate the regulation of transcription factors critical for inflammatory control of HO-1 ..
  8. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..AR) antagonist, L-97-1, as an adjunctive, anti-sepsis treatment in an animal model of polymicrobial sepsis, bacteremia, and endotoxemia (rat cecal ligation and puncture [CLP]). Administration of L-97-1 as a single intravenous (i.v...
  9. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    ..The lipooligosaccharide (LOS) of NTHi contributes to virulence in models of bacteremia and otitis media yet its function in the lung is not well understood...
  10. Role of surface proteins in sand fly colonization by Bartonella bacilliformis
    Michael F Minnick; Fiscal Year: 2013
    ..hematocrit (Oroya fever), whereas in endemic regions, angiomatous skin lesions (verruga peruana) and chronic bacteremia prevail, creating a human reservoir of Bb...
  11. Identification of vaccine antigens based on expression in blood
    PETER TRIP BEERNINK; Fiscal Year: 2011
    ..In Aim 2, we will identify genes that are up-regulated in bacteria isolated from infant rats with bacteremia. In Aim 3 we will express recombinant proteins encoded by NmB genes that are up- regulated during infection and, ..
  12. Regulation of Bacteroides fragilis multidrug efflux pumps
    Hannah Wexler; Fiscal Year: 2013
    ..VA patients are particularly at risk for anaerobic infections. Mortality in Bacteroides bacteremia is high (25- 50%) and liver disease, common in VA patients, is a risk factor for increased mortality...
  13. Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
    Marcel R m van den Brink; Fiscal Year: 2013
    ..BMT patients shows a) a remarkable loss of microbial diversity in allo-HSCT recipients, which is associated with bacteremia and intestinal domination by Enterococci, Streptococci and Staphylococci, and b) an association between ..
  14. Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs
    Dennis L Stevens; Fiscal Year: 2013
    ..Hearts from experimental animals with GAS bacteremia express high levels of only MMP-13...
  15. The Organ Specific Role of Superoxide Dismutase in Sepsis
    Alix Ashare; Fiscal Year: 2010
    ..Other organs impact the degree of bacteremia as well...
  16. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..to invasive and frequently life-threatening infections such as lymphangitis, septic arthritis, osteomyelitis, bacteremia, pneumonia, abscesses of various organs, meningitis, endocarditis, and sepsis...
  17. Molecular mechanisms of pathogen recognition by the Nod-like receptor NLRC4
    Fayyaz S Sutterwala; Fiscal Year: 2012
    ..a variety of acute infections, such as ventilator-associated pneumonias, burn superinfections, neutropenic bacteremia, and medical device-related infections. In addition, P...
  18. Mechanisms of trauma and hemorrhage-induced impairment of innate immunity
    Xiao Di Tan; Fiscal Year: 2013
    ..mice with Pseudonumo aeruginosa followed by assessing the clinical course including survival rate, bacteremia, tissue injury, and inflammatory and cytokine response...
  19. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    ..The lipooligosaccharide (LOS) of NTHi contributes to virulence in models of bacteremia and otitis media yet its function in the lung is not well understood...
  20. Novel gene-silencing therapeutics for multidrug-resistant gram-negative pathogens
    DAVID ELIHU GREENBERG; Fiscal Year: 2013
    ..PPMOS are bactericidal in culture, and reduce bacteremia and improve survival in animal models of infection...
  21. Coordination of metabolism and virulence during infection
    Tony Romeo; Fiscal Year: 2013
    ..of Salmonella that exhibit a variety of host ranges and disease manifestations, which include gastroenteritis, bacteremia, metastatic infections and paratyphoid and typhoid fevers...
  22. Toll-like receptor signaling in the generation of B1b cell memory
    Kishore R Alugupalli; Fiscal Year: 2012
    ..Using the experimental model of Borrelia hermsii bacteremia, we discovered a novel role for B1b cells, a subset of mature B cells, in long-lasting memory responses in the ..
  23. Global Genomic and Proteomic Profiling of African Children with Typhoid Fever
    Stephen Obaro; Fiscal Year: 2013
    ..We have already established a bacteremia surveillance system in central Nigeria since 2008...
  24. Impact of the Nasal Microbiome on S. aureus Colonization and Infection
    Mary Bessesen; Fiscal Year: 2013
    ..data from DVAMC-Denver indicate that MRSA colonization is associated with an 8-fold increased risk for MRSA bacteremia. Decolonization therapy reduces the risk of infection, supporting the hypothesis that colonization leads to ..
  25. Cytokine-stimulated systemic defenses during pneumococcal pneumonia
    Joseph P Mizgerd; Fiscal Year: 2013
    ..2) Test the hypothesis that the hepatic acute phase response limits both dissemination of infection (bacteremia) and dissemination of injury (ARDS and multi-organ failure) during pneumonia, using mice in which the hepatic ..
  26. Multi-specific Antibody Therapy by targeting S. aureus toxins and polysaccharides
    M Javad Aman; Fiscal Year: 2013
    ..In Aim 2 the tri-specific zybodies will be tested in several animal models including bacteremia, pneumonia and skin infection models...
  27. LISTERIA AND SHIGELLA USE ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The gram positive bacillus Listeria monocytogenes causes bacteremia and meningitis, while the gram negative bacillus Shigella flexneri causes severe diarrhea and dehydration...
  28. Synthetic saccharides to study immunological properties of Streptococcus pneumoni
    Alexei V Demchenko; Fiscal Year: 2010
    ..The bacteria Streptococcus pneumoniae (SPn) have become one of the most frequent causes of pneumonia, bacteremia, and meningitis in the elderly, immunocompromised, and especially in young children...
  29. Development of an antimicrobial peptide therapeutic for Pseudomonas infections
    HELOISE ANNE PEREIRA; Fiscal Year: 2011
    ..Our initial indications are for the treatment of bacteremia and nosocomial pneumonia due to P. aeruginosa...
  30. Broad-Spectrum Antimicrobials Targeting the D-Alanine Pathway
    KAREN G ANTHONY; Fiscal Year: 2013
    ..of anthrax, and methicillin-resistant Staphylococcus aureus (MRSA), the causative agent of life threatening bacteremia. This project will be performed by a multidisciplinary team of investigators from academia and industry with ..
  31. Bartonella: dissecting niche-specific adaptation in a human pathogen
    Jane E Koehler; Fiscal Year: 2013
    ..BQ also causes persistent bacteremia and fatal illness in immunocompromised individuals with cancer and HIV/AIDS...
  32. Novel virulence and exoenzyme regulators
    ROBERT M SHANKS; Fiscal Year: 2013
    ..S. marcescens also causes many hospital acquired infections including pneumonia, endocarditis, bacteremia and urinary tract infections that are commonly resistant to current antibiotics and whose outcomes are ..
  33. Ergocalciferol in ESRD Efficacy Safety and Biology
    Ravi Thadhani; Fiscal Year: 2010
    ..weeks, and clinical follow-up and monitoring for infection-associated events (including antibiotic use, rates of bacteremia, and sepsis) will continue for 20 weeks...
  34. Biomechanics of Blood Stream Infections
    John G Younger; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Intravascular device-related blood stream infection is the leading cause of bacteremia in the United States and is a common and life threatening complication among ill and injured patients...
  35. Periodontal Pathogens-induced Atherosclerosis in ApoE-/- and Integrin Beta6-/- mi
    IRINA MARIE VELSKO; Fiscal Year: 2013
    ..infected with Pg+Td+Tf+Fn for 24 weeks, and upon sacrifice will be examined for evidence of periodontal disease, bacteremia and atherosclerosis (Aims 1 and 3)...
  36. Whole Genome Association Analysis of Hematopoietic Cell Transplant (HCT) Outcome
    JOHN ANDREW HANSEN; Fiscal Year: 2013
    ..obstruction (AFO disease/bronchiolitis obliterans syndrome (BOS), acute kidney injury (AKI), Gram negative bacteremia, invasive fungal disease, CMV infection and disease, disease relapse and transplant-related mortality...
  37. Mechanism of Staphylocoagulase-activated Blood Clotting
    Paul E Bock; Fiscal Year: 2013
    ..Endothelial damage on heart valves activates coagulation and concurrent S. aureus bacteremia allows bacteria to bind to the injury site...
  38. The role of PhoP/PhoQ-regulated phospholipid alterations in Salmonella pathogenes
    ZACHARY DALEBROUX; Fiscal Year: 2013
    ..pathogen of worldwide importance causing a variety of diseases including typhoid fever, enterocolitis and bacteremia. Following ingestion of contaminated products, bacteria access the human small intestine...
  39. ET3-EDNRB Signaling in Enterocolitis Associated with Colonic Aganglionosis
    PHILIP KENT FRYKMAN; Fiscal Year: 2013
    ..surgery fails to cure the disorder, and thereafter, children suffer from chronic enterocolitis that can lead to bacteremia, outright sepsis, and even death...
  40. The developing intestinal immune system in Yersinia enterocolitica infection
    REBECCA D ADKINS; Fiscal Year: 2010
    ..The effects of neutralization of ?IFN and/or IL-17 responses on inflammatory cell infiltration, bacteremia, and relative weight loss associated with mortality will be examined...
  41. Elderly Immune Response to Pneumococcal Polysaccharide
    M A JULIA WESTERINK; Fiscal Year: 2010
    ..Despite the use of appropriate antibiotics and intensive care, the case fatality rate of pneumococcal bacteremia has not changed in the past 40 years and remains at 15 to 40%...
  42. Role of Immunogenetic Factors in Invasive Streptococcal Infections
    MALAK Y S KOTB; Fiscal Year: 2012
    ..Because we could recover the same virulent GAS strain (M1T1) from STSS cases as wel as frommild GAS bacteremia cases or even cases with mild pharyngitis, we proposed that host factors may be playing an important role in ..
  43. A Modulator of Innate Immunity for Preventing Hospital-Acquired Infections
    James D Thacker; Fiscal Year: 2010
    ..two downstream effectors - opsonic acute phase proteins and IgM, and it confers protection in an animal model of bacteremia. These observations strongly suggest that PDAG has considerable utility as a novel, immunoregulatory, ..
  44. Virulence Determinants in Staphylococcus Bacteremia
    Steven R Gill; Fiscal Year: 2012
    ..aureus bacteremia. Evaluating the role of these virulence determinants in humans was limited by the absence of a large, well-..
  45. Delayed Onset of Biofilm Formation and CAUTI with Superhydrophobic Catheters
    Sanjiv Lalwani; Fiscal Year: 2011
    ..mild (fever, urethritis and cystitis) to severe (acute pyelonephritis, renal scarring, calculu formation and bacteremia)...
  46. Treatment of bacterial pneumonia after influenza
    Jonathan A McCullers; Fiscal Year: 2010
    ..typically presents at a more advanced stage, has complex features including multi-lobar involvement and bacteremia, and targets the frail and the elderly...
  47. Reduction of Tunneled Dialysis Catheter Dysfunction Via Long Term Nitric Oxide Re
    Prabir Roy-Chaudhury; Fiscal Year: 2013
    ..In 2010, 83,000 patients were admitted to hospitals for TDC related bacteremia or sepsis, and each central line-associated bloodstream nosocomial infection adds ca...
  48. Host-mediated zinc sequestration during Acinetobacter baumannii infection
    Eric P Skaar; Fiscal Year: 2013
    ..of diseases, including respiratory and urinary tract infections, meningitis, endocarditis, wound infections, and bacteremia. In fact, A...
  49. Molecular and Cellular Basis of Toxin Mediated Pathogenesis in Staphylococcus aur
    Francis Alonzo; Fiscal Year: 2013
    ..The organism is a leading cause of suppurative skin lesions, bacterial endocarditis, bacteremia, and pneumonia. Treatment of S...
  50. Identification of Salmonella Genes Important for Systemic Colonization
    Helene L Andrews-Polymenis; Fiscal Year: 2012
    ..that cause hundreds of millions of cases of diarrheal disease and hundreds of thousands of deaths due to bacteremia annually worldwide...
  51. Validating targets in p. aeruginosa type III secretion using chemical probes
    Donald T Moir; Fiscal Year: 2013
    ..aeruginosa virulence determinant contributing to the establishment and dissemination of infections (e.g. VAP, bacteremia, urinary tract infections)...
  52. Inflammasome Response to Bacterial Infection
    Edward A Miao; Fiscal Year: 2013
    ..fever or gastroenteritis, and recently have been observed as emerging pathogens causing community acquired bacteremia in sub-Saharan Africa...
  53. A novel Structure Based Vaccine for staphylococcal alpha hemolysin
    Rajan P Adhikari; Fiscal Year: 2013
    ..candidate in four different mouse models of infection: pneumonia, subcutaneous abscess model representing SSTI, bacteremia/sepsis, and surgical wound infection. This proposal is a collaborative effort between IBT and Dr...
  54. Structure and Cell-Wall Targeting of the Staphylolytic Enzyme Lysostaphin
    KEITH GRISCOM INMAN; Fiscal Year: 2010
    ..Surgical intervention can remove specific foci of infection but cannot address bacteremia and sepsis that frequently make these infections fatal...
  55. Targeting a leukocyte disintegrin metalloprotease during bacterial pneumonia
    Bruce K Walcheck; Fiscal Year: 2013
    ..aeruginosa lung infection and bacteremia in mice...
  56. Is Aberrant MO Stimulation Pivotal in Post-Trauma MODS?
    Carol L Miller-Graziano; Fiscal Year: 2012
    ..we will determine if post trauma MO differentiation to aberrant DC subsets typifies patients developing MOF and bacteremia with 1) MO that express a unique cohorts of interactive, inhibitory mediators/receptors including TSP-1, CD47, ..
  57. A gene therapy for bacterial translocation in mice with whole body irradiation
    Fujio Suzuki; Fiscal Year: 2010
    ..after various severities of whole body gamma-irradiation will be measured by decreased bacterial growth in MLN, bacteremia and mortality rates...
  58. Mutational analysis of the vlp/vsp antigenic variation system of the relapsing fe
    TROY MICHAEL BANKHEAD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A key mechanism for immune evasion and recurrent bacteremia by the East African relapsing fever spirochete, Borrelia duttonii, is antigenic variatio of the Vlp and Vsp surface proteins...
  59. Microwave sterilization of hemodialysis catheter systems
    CLARK MCWHORTER EDSON; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Catheter related bacteremia (CRB) comprises the most common reason for hospitalization for patients with end-stage renal disease (ESRD) ..
  60. Evasion of complement-mediated killing by pathogenic rickettsial species
    Juan J Martinez; Fiscal Year: 2013
    ..rOmpB/Sca5 and RC1281/Adr1, which are sufficient to mediate survival in ex-vivo human serum models of rickettsia bacteremia. We have demonstrated that R...
  61. Mechanisms of effect of iron status &interventions on malaria &other infections
    Steven L Spitalnik; Fiscal Year: 2012
    ..This ferrophilic enteric species is a leading cause of bacteremia in African children with or without malaria...
  62. Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria
    Shahriar Mobashery; Fiscal Year: 2013
    ..Enterococci are the leading cause of nosocomial bacteremia, surgical wound infections, and urinary tract infections...
  63. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    ..Life-threatening complications of bartonellosis can include endocarditis, peliosis hepatis, relapsing bacteremia, encephelopathy and neuroretinitis...
  64. PEPTIDE BASED SALMONELLA VACCINE DELIVERY SYSTEM
    Lee Riley; Fiscal Year: 1999
    ..In this project, this peptide sequence will be used to identify an oral vaccine candidate to protect against bacteremia in a murine model of Salmonella enteritidis infection...
  65. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..a diverse spectrum of human and animal diseases, including wound infections, osteomyelitis, endocarditis, and bacteremia leading to secondary abscesses in any of the major organ systems...
  66. STAPHYLOCOCCUS AUREUS: CAPSULAR ANTIGENS AND IMMUNITY
    Jean Lee; Fiscal Year: 1993
    ..aureus infection (bacteremia)...
  67. INTERACTION OF GROUP A STREP WITH THE PLASMINOGEN SYSTEM
    Michael Boyle; Fiscal Year: 2001
    ..with a variety of diseases including pharyngitis, impetigo, and invasive infections such as cellulitis and bacteremia. Recently, the incidence and severity of streptococcal disease has increased and the exact nature of the ..
  68. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
    ..Chorioamnionitis is a recognized risk factor for bacteremia and septic shock and is associated with a several-fold increase in the risk for cesarean delivery...
  69. Multidrug-Resistant Acinetobacter baumannii
    Yohei Doi; Fiscal Year: 2010
    ..organism that causes serious nosocomial infections such as ventilator-associated pneumonia and bacteremia. A...
  70. MECHANISM FOR TNF-INDUCED MYOCARDIAL DYSFUNCTION
    MARC VISNER; Fiscal Year: 1991
    ..following the systemic release of tumor necrosis factor-alpha (TNFalpha) as would occur during an episode of bacteremia or endo-toxemia...
  71. PGA antigenemia for early diagnosis of anthrax
    Thomas Kozel; Fiscal Year: 2009
    ..results showed that the initial presence of detectable PGA in blood coincided with the occurrence of detectable bacteremia. Full bacteremia was accompanied by a massive antigenemia with antigen titers as high as 1/5,000,000 48 h after ..
  72. Study of S pneumoniae Virulence Gene Regulation
    Andrew Camilli; Fiscal Year: 2002
    ..goal of our research is to understand the pathogenicity of Streptococcus pneumoniae, the most common cause of bacteremia, bacterial meningitis, otitis media and community-acquired pneumonia in the U.S.A...
  73. STREPTOCOCCAL HYALURONATE CAPSULE
    Ivo van de Rijn; Fiscal Year: 1999
    ..Within the last decade, an increase in the number of invasive group A streptococcal infections associated with bacteremia deep soft-tissue infection, shock, and multi- organ failure were observed in patients with no prior underlying ..
  74. Characterization of iron transport in GBS
    KATHRYN CLANCY; Fiscal Year: 2004
    Group B streptococcus is the predominant etiological agent of neonatal bacteremia, sepsis and meningitis, and has been correlated with preterm membrane rupture and premature birth...