rodent diseases

Summary

Summary: Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).

Top Publications

  1. ncbi Catarina virus, an arenaviral species principally associated with Neotoma micropus (southern plains woodrat) in Texas
    Maria N B Cajimat
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Am J Trop Med Hyg 77:732-6. 2007
  2. ncbi Prevalence of Leptospira spp. in urban rodents from a groceries trade center of Medellin, Colombia
    Piedad Agudelo-Florez
    Instituto Colombiano de Medicina Tropical Universidad CES, Colombia
    Am J Trop Med Hyg 81:906-10. 2009
  3. ncbi Rodents as shared indicators for zoonotic parasites of carnivores in urban environments
    L A Reperant
    Institute of Parasitology, University of Zurich, Winterthurerstrasse 266a, CH 8057 Zurich, Switzerland
    Parasitology 136:329-37. 2009
  4. pmc Hantavirus in African wood mouse, Guinea
    Boris Klempa
    Institute of Virology, Charite Medical School, Campus Charite Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Emerg Infect Dis 12:838-40. 2006
  5. ncbi Ultrastructure and phylogenetic analysis of 'Candidatus Neoehrlichia mikurensis' in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks
    Makoto Kawahara
    Nagoya City Public Health Research Institute, Hagiyama cho, Mizuho ku, Nagoya, 467 8615, Japan
    Int J Syst Evol Microbiol 54:1837-43. 2004
  6. ncbi Prevalence of Calodium hepaticum (Syn. Capillaria hepatica) in house mice (Mus musculus) in the Azores archipelago
    A R Resendes
    Department of Biology, University of the Azores, Apartado 1422, 9501 855 Ponta Delgada, Portugal
    Vet Parasitol 160:340-3. 2009
  7. ncbi Testosterone depresses innate and acquired resistance to ticks in natural rodent hosts: a force for aggregated distributions of parasites
    V L Hughes
    Department of Zoology, University of Oxford, UK
    J Parasitol 87:49-54. 2001
  8. ncbi Factors affecting the component community structure of haemoparasites in bank voles (Clethrionomys glareolus) from the Mazury Lake District region of Poland
    A Bajer
    Department of Parasitology, Institute of Zoology, University of Warszawa, Poland
    Parasitology 122:43-54. 2001
  9. ncbi Sympatric Ixodes trianguliceps and Ixodes ricinus ticks feeding on field voles (Microtus agrestis): potential for increased risk of Anaplasma phagocytophilum in the United Kingdom?
    K J Bown
    Department of Veterinary Pathology, University of Liverpool, Liverpool, UK
    Vector Borne Zoonotic Dis 6:404-10. 2006
  10. ncbi Incidence from coincidence: patterns of tick infestations on rodents facilitate transmission of tick-borne encephalitis virus
    S E Randolph
    Department of Zoology, University of Oxford, UK
    Parasitology 118:177-86. 1999

Research Grants

Detail Information

Publications275 found, 100 shown here

  1. ncbi Catarina virus, an arenaviral species principally associated with Neotoma micropus (southern plains woodrat) in Texas
    Maria N B Cajimat
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Am J Trop Med Hyg 77:732-6. 2007
    ....
  2. ncbi Prevalence of Leptospira spp. in urban rodents from a groceries trade center of Medellin, Colombia
    Piedad Agudelo-Florez
    Instituto Colombiano de Medicina Tropical Universidad CES, Colombia
    Am J Trop Med Hyg 81:906-10. 2009
    ..interrogans by sequencing. These data show the role of this natural carrier and shedder of pathogenic leptospires in the epidemiology of urban leptospirosis in Colombia...
  3. ncbi Rodents as shared indicators for zoonotic parasites of carnivores in urban environments
    L A Reperant
    Institute of Parasitology, University of Zurich, Winterthurerstrasse 266a, CH 8057 Zurich, Switzerland
    Parasitology 136:329-37. 2009
    ..These results highlight the potential value of rodents as shared indicators for these pathogens...
  4. pmc Hantavirus in African wood mouse, Guinea
    Boris Klempa
    Institute of Virology, Charite Medical School, Campus Charite Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Emerg Infect Dis 12:838-40. 2006
    ..Sequence and phylogenetic analyses of the genetic material demonstrate a novel hantavirus species, which we propose to name "Sangassou virus."..
  5. ncbi Ultrastructure and phylogenetic analysis of 'Candidatus Neoehrlichia mikurensis' in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks
    Makoto Kawahara
    Nagoya City Public Health Research Institute, Hagiyama cho, Mizuho ku, Nagoya, 467 8615, Japan
    Int J Syst Evol Microbiol 54:1837-43. 2004
    ..It is proposed that this new cluster of bacteria should be designated 'Candidatus Neoehrlichia mikurensis'...
  6. ncbi Prevalence of Calodium hepaticum (Syn. Capillaria hepatica) in house mice (Mus musculus) in the Azores archipelago
    A R Resendes
    Department of Biology, University of the Azores, Apartado 1422, 9501 855 Ponta Delgada, Portugal
    Vet Parasitol 160:340-3. 2009
    ..The high rate of infection found in the present study suggests that house mice are an important reservoir for this parasite in the Azores and could have a role in human transmission...
  7. ncbi Testosterone depresses innate and acquired resistance to ticks in natural rodent hosts: a force for aggregated distributions of parasites
    V L Hughes
    Department of Zoology, University of Oxford, UK
    J Parasitol 87:49-54. 2001
    ..The lowest innate and acquired resistance to tick feeding occurs in that fraction of the host population, i.e., sexually active males, most actively involved in the transmission of both Babesia microti and Borrelia burgdorferi s.l...
  8. ncbi Factors affecting the component community structure of haemoparasites in bank voles (Clethrionomys glareolus) from the Mazury Lake District region of Poland
    A Bajer
    Department of Parasitology, Institute of Zoology, University of Warszawa, Poland
    Parasitology 122:43-54. 2001
    ....
  9. ncbi Sympatric Ixodes trianguliceps and Ixodes ricinus ticks feeding on field voles (Microtus agrestis): potential for increased risk of Anaplasma phagocytophilum in the United Kingdom?
    K J Bown
    Department of Veterinary Pathology, University of Liverpool, Liverpool, UK
    Vector Borne Zoonotic Dis 6:404-10. 2006
    ..trianguliceps, which may alone maintain endemic cycles, and exophilic I. ricinus ticks, which could act as a bridge vector and transmit infections to humans and domesticated animals...
  10. ncbi Incidence from coincidence: patterns of tick infestations on rodents facilitate transmission of tick-borne encephalitis virus
    S E Randolph
    Department of Zoology, University of Oxford, UK
    Parasitology 118:177-86. 1999
    ..This identifies the particular climatic factors that permit such patterns of tick seasonal dynamics as the primary predictors for the focal distribution of TBE...
  11. ncbi Epidemiological and postmortem findings in 262 red squirrels (Sciurus vulgaris) in Scotland, 2005 to 2009
    J P LaRose
    Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Vet Rec 167:297-302. 2010
    ..SQPV infection was associated with the presence of external parasites, but was not associated with the sex of the animals...
  12. ncbi Differences in the ecology of Bartonella infections of Apodemus flavicollis and Myodes glareolus in a boreal forest
    A Paziewska
    National Centre for Biosystematics, Natural History Museum, University of Oslo, PO Box 1172, Blindern, Oslo, Norway
    Parasitology 139:881-93. 2012
    ..This heterogeneity in the patterns of Bartonella infections in wild rodents emphasizes the need to consider variation between both, host species and Bartonella genotypes in ecological and epidemiological studies...
  13. pmc Serologic and molecular studies of Leptospira and leptospirosis among rats in the Philippines
    Sharon Y A M Villanueva
    Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Trop Med Hyg 82:889-98. 2010
    ..Results showed that these four Leptospira serovars and serogroups are circulating among rats, and that these animals may be one of the possible transmission sources of leptospirosis in the Philippines...
  14. pmc Factors affecting patterns of tick parasitism on forest rodents in tick-borne encephalitis risk areas, Germany
    Christian Kiffner
    Department of Forest Zoology and Forest Conservation incl Wildlife Biology and Game Management, Büsgen Institute, Georg August University Gottingen, Büsgenweg 3, 37077, Gottingen, Germany
    Parasitol Res 108:323-35. 2011
    ..mainly fed on M. glareolus and were seldom found on A. flavicollis. Whereas Ixodes spp. is the dominant tick genus in woodlands of our study area, the distribution and epidemiological role of Dermacentor spp. should be monitored closely...
  15. ncbi Tula virus infections in the Eurasian water vole in Central Europe
    Mathias Schlegel
    Friedrich Loeffler Institut, Institute for Novel and Emerging Infectious Diseases, Greifswald Insel Riems, Germany
    Vector Borne Zoonotic Dis 12:503-13. 2012
    ..amphibius. Future longitudinal studies of sympatric Microtus and Arvicola populations and experimental infection studies have to prove the potential of A. amphibius as an additional TULV reservoir host...
  16. ncbi Microclimate and the zoonotic cycle of tick-borne encephalitis virus in Switzerland
    C Burri
    Institute of Biology, Laboratory of Eco Epidemiology of Parasites, University of Neuchatel, Emile Argand 11, 2000 Neuch and tel, Switzerland
    J Med Entomol 48:615-27. 2011
    ..The proportion of hosts with cofeeding ticks seemed to be one of the factors that distinguished a TBEV focus from a non-TBEV focus. The enzootic cycle of TBEV might be disrupted when dry and hot springs occur during consecutive years...
  17. ncbi PCR-based diagnosis for detection of Leishmania in skin and blood of rodents from an endemic area of cutaneous and visceral leishmaniasis in Brazil
    Fernanda S Oliveira
    Laboratório de Sistemática Bioquímica, Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brasil
    Vet Parasitol 129:219-27. 2005
    ..L.) chagasi in a naturally infected T. apereoides. The utility of filter paper as a substrate for PCR analyses and the efficacy of the procedure associated to the hybridization is emphasized...
  18. ncbi Isolation of Toxoplasma gondii from animals in Durango, Mexico
    J P Dubey
    Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Beltsville Agricultural Research Center, United States Department of Agriculture, Beltsville, Maryland 20705 2350, USA
    J Parasitol 95:319-22. 2009
    ..One genotype (the 4 chicken isolates) belongs to the clonal Type III lineage, three genotypes were reported in previous reports, and 1 genotype is unique...
  19. ncbi Effect of deer density on tick infestation of rodents and the hazard of tick-borne encephalitis. II: population and infection models
    L Bolzoni
    Department of Biodiversity and Molecular Ecology, Research and Innovation Centre Fondazione Edmund Mach, San Michele all Adige, Trento, Italy
    Int J Parasitol 42:373-81. 2012
    ..As a consequence, using simply the number of ticks per rodent as a predictor of TBE transmission potential could be misleading if competent hosts share habitats with incompetent hosts...
  20. ncbi Associations between leptospiral infection and seropositivity in rodents and environmental characteristics in Argentina
    N B Vanasco
    Instituto Nacional de Enfermedades, Respiratorias E Coni, Administracion Nacional de Laboratorios e Institutos de Salud, Blas Parera 8260, 3000 Santa Fe, Argentina
    Prev Vet Med 60:227-35. 2003
    ..Adults and subadults had higher seroprevalences than juvenile rodents. Oligoryzomys flavescens had higher seroprevalence than Akodon azarae, Mus musculus, Rattus rattus and Rattus norvegicus...
  21. ncbi Demographic factors associated with prevalence of antibody to Sin Nombre virus in deer mice in the western United States
    Charles H Calisher
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Foothills Campus, Colorado State University, Fort Collins, Colorado 80523, USA
    J Wildl Dis 43:1-11. 2007
    ..Many of these patterns, which will be useful in the development of predictive models of disease risk to humans, were only detected through the application of data collected over a long (10-yr) period and with abundant replication...
  22. pmc New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum
    Feng Liu
    Chinese National Human Genome Center, Shanghai, China
    PLoS Pathog 2:e29. 2006
    ....
  23. pmc Persistent infection or successive reinfection of deer mice with Bartonella vinsonii subsp. arupensis
    Ying Bai
    Bacterial Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80521, USA
    Appl Environ Microbiol 77:1728-31. 2011
    ..Genetic analysis demonstrated that deer mouse-borne bartonella isolates at this site belong to the same species, B. vinsonii subsp. arupensis, demonstrating a specific relationship between B. vinsonii subsp. arupensis and deer mice...
  24. pmc Sangassou virus, the first hantavirus isolate from Africa, displays genetic and functional properties distinct from those of other murinae-associated hantaviruses
    Boris Klempa
    Institute of Virology, Helmut Ruska Haus, Charite Medical School, Berlin, Germany
    J Virol 86:3819-27. 2012
    ..These properties are unique within Murinae-associated hantaviruses and make the virus useful in comparative studies focusing on hantavirus pathogenesis...
  25. ncbi Colonisation and shedding of Lawsonia intracellularis in experimentally inoculated rodents and in wild rodents on pig farms
    A M Collins
    Department of Industry and Investment NSW, Elizabeth Macarthur Agricultural Institute, PMB 4008, Narellan, New South Wales 2567, Australia
    Vet Microbiol 150:384-8. 2011
    ..This study demonstrates that rodents may be an important reservoir of L. intracellularis on piggeries, and hence rodent control is important in disease eradication programs on pig farms...
  26. ncbi Factors affecting the component community structure of haemoparasites in common voles ( Microtus arvalis) from the Mazury Lake District region of Poland
    A Pawelczyk
    Department of Parasitology, Institute of Zoology, University of Warszawa, Miecznikowa 1 Street, 02 096 Warszawa, Poland
    Parasitol Res 92:270-84. 2004
    ....
  27. ncbi Predictive thresholds for plague in Kazakhstan
    Stephen Davis
    Danish Pest Infestation Laboratory, Skovbrynet 14, DK 2800 Kongens Lyngby, Denmark
    Science 304:736-8. 2004
    ..We parameterized predictive models that should reduce the costs of plague surveillance in central Asia and thereby encourage its continuance...
  28. ncbi Cluster of Capillaria hepatica infections in non-commensal rodents from the canton of Geneva, Switzerland
    Leslie A Reperant
    Institute of Parasitology, University of Zurich, Winterthurerstrasse 266a, 8057 Zurich, Switzerland
    Parasitol Res 96:340-2. 2005
    ..2%; CP 19%), and in the water vole Arvicola terrestris scherman (n=466; OP 0.2%; CP 4%). The estimated numbers of C. hepatica eggs isolated from infected livers ranged from 1,914 to 938,000 per animal...
  29. ncbi Retrospective detection by negative contrast electron microscopy of faecal viral particles in free-living wild red squirrels (Sciurus vulgaris) with suspected enteropathy in Great Britain
    D J Everest
    Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB
    Vet Rec 167:1007-10. 2010
    ..Two (2.9 per cent) of the samples were negative for adenovirus but were found to contain rotavirus particles, a novel finding in this species...
  30. ncbi Sin Nombre hantavirus decreases survival of male deer mice
    Angela D Luis
    Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA, USA
    Oecologia 169:431-9. 2012
    ....
  31. pmc Anaplasma phagocytophilum from Rodents and Sheep, China
    Lin Zhan
    Beijing Institute of Microbiology and Epidemiology, Beijing, People s Republic of China
    Emerg Infect Dis 16:764-8. 2010
    ..The multiple sequences of the 3 isolates were identical to each other but different from all known strains from other countries. The public health and veterinary relevance of the isolates deserves further investigation...
  32. pmc Multiple co-infections of rodents with hantaviruses, Leptospira, and Babesia in Croatia
    Ante Tadin
    University Hospital for Infectious Diseases Dr Fran Mihaljevic, Research Department, Zagreb, Croatia
    Vector Borne Zoonotic Dis 12:388-92. 2012
    ..Since hantaviruses, Leptospira, and Babesia have similar geographical distributions, it is to be expected that in other parts of the world multiple co-infections, representing a serious threat to public health, can be found...
  33. ncbi Effects of deer density on tick infestation of rodents and the hazard of tick-borne encephalitis. I: empirical assessment
    F Cagnacci
    Department of Biodiversity and Molecular Ecology, Research and Innovation Centre, Fondazione Edmund Mach, Via E Mach 1, I 38010 San Michele all Adige, Trento, Italy
    Int J Parasitol 42:365-72. 2012
    ....
  34. pmc Bartonella species in small mammals and their ectoparasites in Taiwan
    Yi Lun Tsai
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Am J Trop Med Hyg 83:917-23. 2010
    ..tribocorum, B. phoceensis, and B. rattimassiliensis were detected in lice obtained from small mammals. A broader range of Bartonella species was identified in the ectoparasites than in the small mammals...
  35. ncbi Jungles: a new solution to the host/parasite phylogeny reconciliation problem
    M A Charleston
    Division of Environmental and Evolutionary Biology, University of Glasgow, UK
    Math Biosci 149:191-223. 1998
    ..A simple example is given, and the pocket gopher/chewing louse system investigated by Hafner and Nadler [Hafner and Nadler, Nature 332 (1988) 258] is re-examined...
  36. pmc Parasitic loads in tissues of mice infected with Trypanosoma cruzi and treated with AmBisome
    Sabrina Cencig
    Laboratoire de Parasitologie, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Negl Trop Dis 5:e1216. 2011
    ..AmBisome (liposomal amphotericin B), already shown efficient after administration for some days in human and experimental infection with Leishmania, has been scarcely studied in T. cruzi infection...
  37. pmc Genotype diversity and distribution of Orientia tsutsugamushi causing scrub typhus in Thailand
    Toon Ruang-areerate
    Research Division, Armed Forces Research Institute of Medical Science, Bangkok 10400, Thailand
    J Clin Microbiol 49:2584-9. 2011
    ..Thus, these new genotypes should be considered for future scrub typhus assay and vaccine development...
  38. pmc Diversity among Tacaribe serocomplex viruses (family Arenaviridae) naturally associated with the Mexican woodrat (Neotoma mexicana)
    Maria N B Cajimat
    Microbiology and Immunology Graduate Program, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    Virus Res 133:211-7. 2008
    ..Conceptually, the viruses from Colorado, New Mexico, and Utah and strain AV 9310135 could be grouped together in a species complex in the family Arenaviridae, genus Arenavirus...
  39. ncbi Transmission of Black Creek Canal virus between cotton rats
    K L Hutchinson
    Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Med Virol 60:70-6. 2000
    ..J. Med. Virol. 60:70-76, 2000. Published 2000 Wiley-Liss, Inc...
  40. pmc Leishmania species: detection and identification by nested PCR assay from skin samples of rodent reservoirs
    Amir Ahmad Akhavan
    Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Exp Parasitol 126:552-6. 2010
    ..major and L. turanica, 1.1% by L. major and L. gerbilli, and 2.1% by the three species. We concluded that this method is simple and reliable for detecting and identifying Leishmania species circulating in rodent populations...
  41. ncbi Histological study of Trichosomoides nasalis (Nematoda: Trichinelloidea) in the nasal cavities of the murid Arvicanthis niloticus, with associated pathology
    M Diagne
    Departement de Biologie Animale, Faculte des Sciences, Universite Cheikh Anta Diop, Dakar, Senegal
    Parasite 11:351-8. 2004
    ..which live in this part of the mucosa. In rodents, the lesions resulted in rhinosinusitis characterised by a lymphocytic infiltration leading to nasal obstruction...
  42. ncbi Abundance of wild rodents, ticks and environmental risk of Lyme borreliosis: a longitudinal study in an area of Mazury Lakes district of Poland
    Edward Sinski
    Department of Parasitology, Institute of Zoology, University of Warsaw, Miecznikowa 1, 02 096 Warsaw, Poland
    Ann Agric Environ Med 13:295-300. 2006
    ..It follows, therefore, that any factor which reduces the relative density of A. flavicollis in comparison to other hosts in the wild rodent community, will reduce also the risk of human exposure to Lyme borreliosis spirochetes...
  43. ncbi Molecular survey of Babesia microti in wild rodents in central Croatia
    Relja Beck
    Department for Bacteriology and Parasitology, Croatian Veterinary Institute, Zagreb, Croatia
    Vector Borne Zoonotic Dis 11:81-3. 2011
    ..The results of this study indicate the presence of zoonotic B. microti in A. flavicollis and M. glareolus in Croatia and a potential risk for human health...
  44. ncbi Male hosts are responsible for the transmission of a trophically transmitted parasite, Pterygodermatites peromysci, to the intermediate host in the absence of sex-biased infection
    Lien T Luong
    Center for Infectious Disease Dynamics, Department of Biology, 208 Mueller Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    Int J Parasitol 39:1263-8. 2009
    ..We also investigated whether variation in nematode length between male and female hosts could account for this male-biased infectivity, but found no evidence to support that hypothesis...
  45. ncbi A longitudinal study of Junin virus activity in the rodent reservoir of Argentine hemorrhagic fever
    J N Mills
    Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland
    Am J Trop Med Hyg 47:749-63. 1992
    ..These distinct, but previously undocumented, habitat preferences suggest that the disease in humans may be related to exposures to the primary reservoir species, C. musculinus, in border habitats rather than in crop fields...
  46. ncbi Natural tick-borne encephalitis virus infection among wild small mammals in the southeastern part of western Siberia, Russia
    Valentina N Bakhvalova
    Institute of Systematics and Ecology of Animals, The Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
    Vector Borne Zoonotic Dis 6:32-41. 2006
    ..Taken together, the data suggest that small mammals may maintain TBEV as a persistent infection throughout the year...
  47. ncbi Migration behaviour and pathogenesis of five ascarid nematode species in the Mongolian gerbil Meriones unguiculatus
    S Cho
    Department of Veterinary Parasitology, Azabu University, Fuchinobe 1 17 71, Sagamihara 229 8501, Japan
    J Helminthol 81:43-7. 2007
    ..Fatal neurological disturbances were observed in B. procyonis-infected gerbils, whereas irreversible non-fatal neurological symptoms were observed in the case of B. transfuga...
  48. ncbi Utilisation of rodent species by larvae and nymphs of hard ticks (Ixodidae) in two habitats in NE Poland
    Anna Paziewska
    University of Warsaw, Warsaw, Poland
    Exp Appl Acarol 50:79-91. 2010
    ..The impact of habitat change (in this case successional change following field abandonment) on tick densities is emphasised, and the role of Apodemus as an epidemiological bridge, linking woodland and field habitats, is highlighted...
  49. ncbi Pathogenesis of experimental vesicular stomatitis virus (New Jersey serotype) infection in the deer mouse (Peromyscus maniculatus)
    T E Cornish
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, USA
    Vet Pathol 38:396-406. 2001
    ..The documentation of viremia in these animals suggests that they may have a role in the epidemiology of vector-borne vesicular stomatitis...
  50. pmc Role of Cannomys badius as a natural animal host of Penicillium marneffei in India
    Harish Gugnani
    Department of Medical Mycology, University of Delhi, India
    J Clin Microbiol 42:5070-5. 2004
    ..This demonstrates the utility of an MLMT-based approach to elucidating the epidemiology of P. marneffei...
  51. ncbi Calodium hepaticum (syn. Capillaria hepatica) in captive rodents in a zoological garden
    S P Redrobe
    Bristol Zoo Gardens, Guthrie Road, Clifton, Bristol BS8 3HA, UK
    J Comp Pathol 133:73-6. 2005
    ..As C. hepaticum is potentially zoonotic, members of staff in zoos should be careful to avoid soil-to-mouth contact, particularly in prairie dog enclosures...
  52. ncbi Study on the movement of Rattus rattus and evaluation of the plague dispersion in Madagascar
    Soanandrasana Rahelinirina
    Institut Pasteur de Madagascar, WHO Collaborating Centre for Plague, Antananarivo, Madagascar
    Vector Borne Zoonotic Dis 10:77-84. 2010
    ..The three study habitats were the risk areas for plague transmission, but the risk appeared highest in the houses and sisals. Rats' movements according to the season were likely directed by the availability of food...
  53. pmc Recombination within and between species of the alpha proteobacterium Bartonella infecting rodents
    Anna Paziewska
    Department of Parasitology, Institute of Zoology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02 096, Warsaw, Poland
    Microb Ecol 61:134-45. 2011
    ..Bartonella clades infecting Microtus were most frequently involved in recombination and were most frequently tip clades within the cladogram. The role of Microtus in influencing the frequency of Bartonella recombination remains unknown...
  54. ncbi Molecular diversity and phylogeny of Hantaan virus in Guizhou, China: evidence for Guizhou as a radiation center of the present Hantaan virus
    Yang Zou
    Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping Liuzi 5, 102206 Beijing, PR China
    J Gen Virol 89:1987-97. 2008
    ..Our results reveal that the highest genetic diversity of HTNV is in a limited geographical region of Guizhou, and suggest that Guizhou might be a radiation centre of the present form of HTNV...
  55. pmc Cowpox virus infection in natural field vole Microtus agrestis populations: significant negative impacts on survival
    Sarah Burthe
    Department of Veterinary Pathology, University of Liverpool, Liverpool, UK
    J Anim Ecol 77:110-9. 2008
    ..6. This negative correlation between cowpox virus infection and field vole survival, with its potentially significant effect on population growth rate, is the first for an endemic pathogen in a cyclic population of wild rodents...
  56. ncbi Experimental inoculation of porcine circoviruses type 1 (PCV1) and type 2 (PCV2) in rabbits and mice
    Josefina Quintana
    Centre de Recerca en Sanitat Animal, Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Vet Res 33:229-37. 2002
    ..However, intraperitoneally inoculated mice might have harboured PCV2 in circulation without evidence of viral replication...
  57. ncbi Capillaria hepatica infection in wild brown rats (Rattus norvegicus) from the urban area of Milan, Italy
    R Ceruti
    Istituto di Anatomia Patologica Veterinaria e Patologia Aviare, , Milan, Italy
    J Vet Med B Infect Dis Vet Public Health 48:235-40. 2001
    ..Our results suggest that the potential transmission of C. hepatica to children in the study area should be considered an important health issue...
  58. ncbi Seoul virus in patients and rodents from Beijing, China
    Shu Qing Zuo
    Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
    Am J Trop Med Hyg 78:833-7. 2008
    ..7% for one of the cases of HFRS--the human- and Rattus norvegicus-originated SEOV sequences--had only two silent substitutions, suggesting genetic analysis is an essential tool for "case-investigation."..
  59. ncbi Emergence and persistence of hantaviruses
    S L Klein
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr Top Microbiol Immunol 315:217-52. 2007
    ..In addition, we summarize all these complexities and provide suggestions for future research directions...
  60. ncbi Transmission efficiency of two flea species (Oropsylla tuberculata cynomuris and Oropsylla hirsuta) involved in plague epizootics among prairie dogs
    Aryn P Wilder
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    Ecohealth 5:205-12. 2008
    ..tuberculata cynomuris abundance, and in September-October when O. hirsuta is common. Our findings may be useful in determining the timing of insecticidal dusting to slow plague transmission in black-tailed prairie dogs...
  61. pmc Babesia spp. and Anaplasma phagocytophilum in questing ticks, ticks parasitizing rodents and the parasitized rodents--analyzing the host-pathogen-vector interface in a metropolitan area
    Cornelia Silaghi
    Comparative Tropical Medicine and Parasitology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Parasit Vectors 5:191. 2012
    ..and Anaplasma phagocytophilum in restored areas in both questing and host-attached Ixodes ricinus and Dermacentor reticulatus and their small mammalian hosts...
  62. ncbi Murine endogenous retroviruses
    C Stocking
    Heinrich Pette Institute, Hamburg, Germany
    Cell Mol Life Sci 65:3383-98. 2008
    ..We review mechanisms by which an adaptive coexistence has evolved. (Part of a multi-author review)...
  63. ncbi Rickettsia spp. in wild small mammals in Lower Bavaria, South-Eastern Germany
    Susanne Schex
    Bundeswehr Institute of Microbiology, Munich, Germany
    Vector Borne Zoonotic Dis 11:493-502. 2011
    ..However, with the course of infection and its transmission in wild animals still unknown, further investigations are needed to better understand the natural cycle of SFG rickettsiae...
  64. ncbi Variables that modulate the spatial distribution of Trypanosoma cruzi and Trypanosoma evansi in the Brazilian Pantanal
    H M Herrera
    Laboratório de Biologia de Tripanosomatídeos, Departamento de Protozoologia, FIOCRUZ RJ, Av Brasil 4365, CEP 21045 900, Rio de Janeiro, RJ, Brazil
    Acta Trop 102:55-62. 2007
    ..Together with the observation that small mammals diversity in FA is similar to RN area suggest that ranching activity may also not necessarily conduct to biodiversity loss or risk of Chagas disease...
  65. ncbi Host specificity of Trypanosoma (Herpetosoma) species: evidence that bank voles (Clethrionomys glareolus) carry only one T. (H.) evotomys 18S rRNA genotype but wood mice (Apodemus sylvaticus) carry at least two polyphyletic parasites
    H A Noyes
    Animal Genetics Laboratory, School of Biological Sciences, Donnan Laboratories, University of Liverpool, UK
    Parasitology 124:185-90. 2002
    ..microti of voles. Fifty-six fleas collected from the rodents were also screened for trypanosomes; 9 were infected with T. evotomys and 1 with T. grosi. One of the fleas infected with T. evotomys was collected from a wood mouse...
  66. pmc Transmission study of Andes hantavirus infection in wild sigmodontine rodents
    P Padula
    Servicio Biología Molecular, Departamento de Virologia, Instituto Nacional de Engermedades Infecciosas, Buenos Aires, Argentina
    J Virol 78:11972-9. 2004
    ..Our study suggests that AND hantavirus may be principally transmitted via saliva or saliva aerosols rather than via feces and urine...
  67. ncbi Endo-parasite fauna of rodents caught in five wet markets in Kuala Lumpur and its potential zoonotic implications
    S Paramasvaran
    Epidemiology and Biostatistics Unit, Institute for Medical Research, Jalan Pahang, Kuala Lumpur
    Trop Biomed 26:67-72. 2009
    ..The following parasites are of potential medical importance: C. hepatica, G. neoplasticum, R. tani, S. muris, H. diminuta, H. nana, Raillietina sp. and T. taeniaeformis...
  68. ncbi Echinococcus multilocularis on Svalbard: introduction of an intermediate host has enabled the local life-cycle
    H Henttonen
    Vantaa Research Centre, Finnish Forest Research Institute
    Parasitology 123:547-52. 2001
    ..The high prevalence and the simplicity of the vole-arctic fox-E. multilocularis system at Svalbard makes it an eminent model system for further epidemiological studies...
  69. pmc Both nonstructural proteins NS1 and NS2 of pneumonia virus of mice are inhibitors of the interferon type I and type III responses in vivo
    Britta Heinze
    Institute of Virology and Immunobiology, Julius Maximilian University, Versbacher Strasse 7, D 97078 Wurzburg, Germany
    J Virol 85:4071-84. 2011
    ..The fact that virulence of rPVM lacking NS2 was not recovered completely when both interferon receptors were deleted suggests that NS2 may have further functions outside the IFN system...
  70. ncbi Association between the DQA MHC class II gene and Puumala virus infection in Myodes glareolus, the bank vole
    Julie Deter
    Centre de Biologie et de Gestion et des Populations, Département INRA EFPA 1062, Campus International de Baillarguet, CS 30016, 34988 Montferrier sur Lez, France
    Infect Genet Evol 8:450-8. 2008
    ..Other datasets are now required to confirm these results and to test whether the associations vary in space and/or time...
  71. ncbi Sex differences in immune responses and viral shedding following Seoul virus infection in Norway rats
    S L Klein
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 65:57-63. 2001
    ..e., IgG2a, IFNgamma, and IL-2) than females; in contrast, Th2 immune responses (i.e., IgG1, IL-4, and IL-10) were similar between the sexes. These data suggest that immune responses to Seoul virus differ between the sexes...
  72. ncbi Zoonotic reservoir of Babesia microti in Poland
    Grzegorz Karbowiak
    W Stefański Institute of Parasitology of Polish Academy of Sciences, 00 818 Warsaw, Poland
    Pol J Microbiol 53:61-5. 2004
    ..microti in Szczecin and Tri-City, the rate was 6.2-13.3%. The variation in B. microti prevalence in rodents and ticks is very changeable and determined by season, the interaction with other hemoparasites, host's age and local conditions...
  73. ncbi Flea diversity and infestation prevalence on rodents in a plague-endemic region of Uganda
    Gerald Amatre
    Uganda Virus Research Institute, Entebbe, Uganda
    Am J Trop Med Hyg 81:718-24. 2009
    ..Future studies are needed to determine whether flea abundance or species composition changes during epizootics when humans are most at risk of exposure...
  74. pmc Analysis of wild-derived mice for Fv-1 and Fv-2 murine leukemia virus restriction loci: a novel wild mouse Fv-1 allele responsible for lack of host range restriction
    C A Kozak
    J Virol 55:281-5. 1985
    ..Only M. spretus was resistant to virus-induced splenomegaly and did not restrict replication of Friend virus helper murine leukemia virus. Genetic studies confirmed that this mouse carries the resistance allele at Fv-2...
  75. pmc Sympatric occurrence of 3 arenaviruses, Tanzania
    Joelle Gouy de Bellocq
    Evolutionary Ecology Group, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Emerg Infect Dis 16:692-5. 2010
    ..We found that 2 rodent species other than Mastomys natalensis mice carry arenaviruses. Analysis of 340 nt of the viral RNA polymerase gene showed sympatric occurrence of 3 distinct arenaviruses...
  76. pmc Contact heterogeneity in deer mice: implications for Sin Nombre virus transmission
    Christine A Clay
    Department of Biology, Westminster College, 1840 South 1300 East, Salt Lake City, UT 84105, USA
    Proc Biol Sci 276:1305-12. 2009
    ..Larger-bodied individuals appear to be the functional group with the greatest SNV transmission potential. Contrary to our predictions, transmission potential was not influenced by breeding condition or sex...
  77. ncbi Antibody to sin nombre virus in rodents associated with peridomestic habitats in west central Montana
    A J Kuenzi
    Department of Biology, Montana Tech of the University of Montana, Butte 59701, USA
    Am J Trop Med Hyg 64:137-46. 2001
    ..Peridomestic settings presented higher concentrations of virus and may present a higher risk of human infection than do sylvan settings...
  78. ncbi Seroprevalence of Toxoplasma gondii antibodies in the rodent capybara (Hidrochoeris hidrochoeris) from Brazil
    W A Cañón-Franco
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Avenida Prof Orlando Marques de Paiva, 87, Cidade Universitaria, Sao Paulo, São Paulo CEP 05508 000, Brazil
    J Parasitol 89:850. 2003
    ..Using IFAT, antibodies (>1:16) were found in 104 (69.8%) and with the MAT, antibodies (>1:25) were found in 63 (42.3%) capybaras. This is the first report of prevalence of T. gondii antibodies in this host...
  79. ncbi Leptospira exposure in the human environment in France: A survey in feral rodents and in fresh water
    F Aviat
    Unité de Bactériologie Médicale et Moléculaire des Leptospires, Ecole Nationale Veterinaire de Nantes, BP 40706, 44307 Nantes Cedex 3, France
    Comp Immunol Microbiol Infect Dis 32:463-76. 2009
    ..Moreover 5/38 water samples associated with human cases were hap1PCR positive and 1/113 in controlled waters...
  80. ncbi A survey of Neospora caninum and Toxoplasma gondii infection in urban rodents from Brazil
    Vanessa Muradian
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    J Parasitol 98:128-34. 2012
    ..In conclusion, the surveys of N. caninum and T. gondii infection in Rattus rattus , Rattus norvegicus , and Mus musculus captured in urban areas of São Paulo reveal a striking low frequency of occurrence of these infections...
  81. ncbi Two new species of Eimeria Schneider 1875 (Apicomplexa: Eimeriidae) from the broad-toothed field mouse, Apodemus mystacinus Danford and Alston 1877 (Rodentia: Muridae) from Jordan
    Lada Hůrková
    Department of Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 61242 Brno, Czech Republic
    Parasitol Res 97:33-40. 2005
    ..The third species, developing in jejunum, has oocysts morphologically indistinguishable from Eimeria uptoni. The identity of E. uptoni and the taxonomy of Eimeria of Apodemus are discussed...
  82. ncbi Molecular phylogenies suggest the oocyst residuum can be used to distinguish two independent lineages of Eimeria spp in rodents
    X Zhao
    Department of Biology, The University of New Mexico, Albuquerque 87131, USA
    Parasitol Res 87:638-43. 2001
    ....
  83. ncbi Analyses of gene flow among populations of deer mice (Peromyscus maniculatus) at sites near hantavirus pulmonary syndrome case-patient residences
    J Jeffrey Root
    Department of Microbiology AIDL, Colorado State University, Fort Collins, Colorado 80523, USA
    J Wildl Dis 39:287-98. 2003
    ..Overall, these data indicate that SNV trafficking is more likely at the local level, but some long-distance trafficking may be possible, especially where select habitat variables favor long-distance movements...
  84. ncbi Detection of Dobrava-Belgrade hantavirus using recombinant-nucleocapsid-based enzyme-linked immunosorbent assay and SYBR Green-based real-time reverse transcriptase-polymerase chain reaction
    Viktoria Nemeth
    Virological Research Group, Faculty of Sciences, Institute of Biology, University of Pecs, Ifjúság út 6, 7624 Pecs, Hungary
    Arch Virol 156:1655-60. 2011
    ..We conclude that the prevalence of DOBV is much higher than previously anticipated. The simultaneous use of molecular and serological techniques provides a highly reliable way to detect hantavirus infections...
  85. ncbi First detection of Leishmania major in Rattus norvegicus from Fars Province, Southern Iran
    Mohammad Hossein Motazedian
    Department of Parasitology and Mycology, Shiraz University of Medical Sciences, Shiraz, Iran
    Vector Borne Zoonotic Dis 10:969-75. 2010
    ..norvegicus in Iran or elsewhere, the rodent can be considered as a possible reservoir in transmission of the disease in Fars Province, and it should be brought into consideration when planning for preventive measures...
  86. pmc Delayed density-dependent prevalence of Sin Nombre virus infection in deer mice (Peromyscus maniculatus) in central and western Montana
    Scott Carver
    Department of Biology, Montana Tech of University of Montana, 1300 Park Street, Butte, Montana 59701, USA
    J Wildl Dis 47:56-63. 2011
    ..Our study suggests predicting local, human exposure risk to SNV in spring, based on deer mouse abundance in autumn, is unlikely to be a reliable public health tool, particularly at local scales...
  87. ncbi Seasonal variation in Sin Nombre virus infections in deer mice: preliminary results
    M Denise Dearing
    Department of Biology, University of Utah, Salt Lake City, Utah, USA
    J Wildl Dis 45:430-6. 2009
    ..Based on the results, coupled with those from the literature, we speculate that the majority of new infections may occur predominantly in the spring and that SNV may impair reproductive output of females...
  88. ncbi Changes in sin nombre virus antibody prevalence in deer mice across seasons: the interaction between habitat, sex, and infection in deer mice
    Jessica M C Pearce-Duvet
    Biology Department, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    J Wildl Dis 42:819-24. 2006
    ..6, P = 0.05); and seropositive mice had more scars (t = 2.5, P = 0.02). We speculate nesting behavior could maintain SNV over the winter, whereas summer territoriality could be responsible for transmission...
  89. ncbi Characterization of Leishmania infection in rodents from endemic areas of the Islamic Republic of Iran
    M Mohebali
    School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    East Mediterr Health J 10:591-9. 2004
    ..7% of 504 rodents. Two species were positive on culture; promastigotes isolated from Mer. persicus were characterized as L. donovani zymodeme LON50 and from Mesocricetus auratus as L. infantum LON49...
  90. ncbi Molecular detection of Leishmania infantum in wild rodents (Rattus norvegicus) in Greece
    E Papadogiannakis
    Department of Veterinary Public Health, National School of Public Health, Athens, Greece
    Zoonoses Public Health 57:e23-5. 2010
    ..This is the first documented case of detection of L. infantum in R. norvegicus in Greece. The results of this preliminary study indicate that R. norvegicus is unlikely to be a reservoir for Leishmania parasites in Greece...
  91. ncbi Variation in the helminth community structure in bank voles (Clethrionomys glareolus) from three comparable localities in the Mazury Lake District region of Poland
    J M Behnke
    School of Life and Environmental Sciences, University of Nottingham, University Park, UK
    Parasitology 123:401-14. 2001
    ....
  92. ncbi Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato
    M B Castro
    Vector-Borne Disease Section, Division of Communicable Disease Control, California Department of Health Services, Santa Rosa 95404, USA
    Am J Trop Med Hyg 65:261-7. 2001
    ..phagocytophila. Borrelia burgdorferi, the agent of Lyme disease, was cultured from ear punch biopsies from six of seven E. phagocytophila seropositive and one of four seronegative wood rats...
  93. ncbi Gastrointestinal helminth parasites of the black rat (Rattus rattus) in Abeokuta, southwest Nigeria
    C F Mafiana
    Department of Biological Sciences, University of Agriculture, Abeokuta, Ogun State, Nigeria
    J Helminthol 71:217-20. 1997
    ..3). Moniliformis moniliformis was the most common species encountered (39.2%) and had the highest mean intensity in both sexes (x=7.4+/-0.74). Considering the rat-man proximity, this finding has considerable public health implications...
  94. pmc Population density and seasonality effects on Sin Nombre virus transmission in North American deermice (Peromyscus maniculatus) in outdoor enclosures
    Karoun H Bagamian
    Population Biology, Ecology, and Evolution Program, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e37254. 2012
    ..Seasonality may have a stronger influence on disease transmission dynamics than host population density, and density effects cannot be considered independent of seasonality...
  95. pmc Genetic evidence of Dobrava virus in Apodemus agrarius in Hungary
    J J Scharninghausen
    Texas A and M University, College Station 77843, USA
    Emerg Infect Dis 5:468-70. 1999
    ..The samples we isolated group with DOB samples previously isolated from A. flavicollis. This grouping may indicate host switching...
  96. ncbi Human leptospirosis cases and the prevalence of rats harbouring Leptospira interrogans in urban areas of Tokyo, Japan
    Nobuo Koizumi
    Department of Bacteriology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    J Med Microbiol 58:1227-30. 2009
    ..Antibodies against these serovars and their DNA were detected in the patients. This suggests that rats are important reservoirs of leptospirosis, and that rat-borne leptospires occur in urban areas of Tokyo...
  97. ncbi Isolation of Leptospira interrogans from suburban rats in Tandil, Buenos Aires, Argentina
    E Scialfa
    División Zoonosis Rurales, España 770, 7300 Azul, Provincia de Buenos Aires, Argentina
    Rev Argent Microbiol 42:126-8. 2010
    ..These findings showed a high density of suburban rodents highly infected with pathogenic leptospira, sharing environment in close contact with humans with evidence of leptospiral disease...
  98. ncbi Serosurvey of wild rodents for hantaviruses in Panama, 2000-2002
    Jorge Salazar-Bravo
    Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409, USA
    J Wildl Dis 40:103-9. 2004
    ..However, given the total number of animals tested, the role of these rodent species in the epidemiology and epizootiology of hantavirus infections remains unclear...
  99. ncbi Parasitic zoonoses at the rodent-captive primate-human health interface
    Hany M Elsheikha
    School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, United Kingdom
    J Egypt Soc Parasitol 39:447-60. 2009
    ..Finally, priorities for future research are identified, including identifying those parasites for which multi-host interaction is likely to have the greatest impact...
  100. ncbi Detection of Dobrava hantaviruses in Apodemus agrarius mice in the Transdanubian region of Hungary
    Ferenc Jakab
    Institute of Biology, University of Pecs, Pecs, Hungary
    Virus Res 128:149-52. 2007
    ..agrarius mice in Slovenia. Based on our new data from the region we concluded that extended reservoir studies would be necessary in the future...
  101. ncbi Biotic and abiotic effects on endoparasites infecting Dipodomys and Perognathus species
    K H Decker
    The University of New Mexico, Department of Biology, Albuquerque 87131 1091, USA
    J Parasitol 87:300-7. 2001
    ..The parasite prevalences in these rodents on the SNWR vary in independent and complex ways...

Research Grants48

  1. SCREENING MICE FOR AUDITORY & NEUROBEHAVIORAL PHENOTYPES
    JAMES WILLOTT; Fiscal Year: 2002
    ..Johnson. This will be accompanied by development of an easy-to-use software/ hardware package that will integrate all screening techniques in a single, serial protocol for use on individual mice. ..
  2. PATHOGENESIS OF MURINE PARVOVIRUS FIELD STRAINS
    David Besselsen; Fiscal Year: 2007
    ..In addition, these studies will provide information about perturbations in host physiology and gene expression induced by murine parvoviruses, and basic scientific information about parvovirus host interaction. ..
  3. Fixed Equipment for DDB Animal Resource
    MARVIN SWINDLE; Fiscal Year: 2009
    ..The requested equipment will provide protection against the spread of complicating rodent diseases in the facilities.
  4. 5 NUCLEASE ASSAYS FOR RODENT HEALTH MONITORING
    David Besselsen; Fiscal Year: 2002
    ..FFPNA will greatly enhance the diagnostic capabilities for routine health monitoring of laboratory rodents and will provide a viable, cost-effective alternative for RAP testing. ..
  5. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  6. Improvement of Facilities Used for BL2 Animal Research
    JAMES MACY; Fiscal Year: 2005
    ..abstract_text> ..
  7. UW Oshkosh Animal Facility Improvement
    DANA VAUGHAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. Mark I Model 68A Rodent/Cell line Gamma Irradiator
    Sanford Feldman; Fiscal Year: 2004
    ....
  9. COMPARATIVE MEDICAL SCIENTIST POSTDOCTORAL TRAINING
    Trenton Schoeb; Fiscal Year: 2006
    ..abstract_text> ..
  10. Cellular and Molecular Mediators of Hantavirus Infection
    Sabra Klein; Fiscal Year: 2006
    ..abstract_text> ..
  11. Lupus locus, Sle3- innate and adaptive immunity
    Chandra Mohan; Fiscal Year: 2005
    ..In particular, biochemical and genetic studies will be carried out to determine if S/e3 might impact the My D88 or TRIF dependent signaling pathways. ..
  12. RESEARCH TRAINING FOR VETERINARIANS: ANIMAL MODELS
    John Sundberg; Fiscal Year: 2008
    ..The investigators ask to maintain the three slots currently funded. This program is designed to meet the increasing demand for scientists in functional genomics research. ..
  13. Liposomal Opioids Extend Analgesia in Laboratory Animals
    Lisa Krugner Higby; Fiscal Year: 2008
    ..If proven efficacious, these analgesic regimens would lead to a significant change in the post-surgical care of animals used in biomedical research and veterinary medicine. ..
  14. MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEAR
    ROBIN BREY; Fiscal Year: 2006
    ..Much will be learned about the relative importance of genetic factors and autoantibodies on vascular disease risk in SLE that is likely to apply to other populations also at increased risk for cerebral ischemia and vascular dementia. ..
  15. NEUROTROPIC CYTOMEGALOVIRUS DURING IMMUNOSUPPRESSION
    JON REUTER; Fiscal Year: 2006
    ..abstract_text> ..
  16. PATHOLOGY OF THE LABORATORY MOUSE
    John Sundberg; Fiscal Year: 2006
    ..The Workshop will accommodate 16 participants who will have an opportunity to interact with a group of prominent mouse pathologists and geneticists from both TJL, and other leading institutions. ..
  17. Alopecia and Ulcerative Dermatitis in B6 Mice
    John Sundberg; Fiscal Year: 2007
    ..Future work will apply findings to human patients to either modify lifestyle or more appropriately treat CCCA to reduce suffering and disfiguration. [unreadable] [unreadable] [unreadable]..
  18. Origin of the Dermal Fibroblast
    Stephen Clark; Fiscal Year: 2006
    ..abstract_text> ..
  19. Impact of lupus susceptibility loci on B-cell tolerance
    Chandra Mohan; Fiscal Year: 2007
    ..Understanding how these loci/genes function will not only broaden our perspective of this disease, but will also point to potential targets for therapeutic intervention. ..
  20. High fat feeding and intramyocellular lipid abnormality
    ZengKui Guo; Fiscal Year: 2005
    ..Thus, the proposed research will improve the understanding of the mechanism of insulin resistance and imcTG abnormalities in the obese rat that will benefit investigation of human obesity. ..
  21. WORLD REFERENCE CENTER FOR ARBOVIRUSES
    Robert Tesh; Fiscal Year: 2002
    ..abstract_text> ..
  22. CYSTEINE PROTEINASES AS LEISHMANIAL VIRULENCE FACTORS
    LAURENCE BUXBAUM; Fiscal Year: 2002
    ..D. and Ph.D. degrees, with thesis research in the GPI anchor of African trypanosomes. He has completed his clinical training in Internal Medicine and a clinical year of Infectious Diseases at the University of Pennsylvania. ..
  23. IMMUNOGENETIC AND CELLULAR ORIGINS OF NEPHROPHILIC ANAS
    Chandra Mohan; Fiscal Year: 2003
    ..NZMc1 mice that also bear the CD43++ knockout, or the lpr allele, for serological and clinical evidence of component lupus phenotypes. ..
  24. XENOBIOTIC-OXIDIZING P450 SYSTEM IN A WHITE ROT FUNGUS
    Jagjit Yadav; Fiscal Year: 2003
    ..chrysosporium constructed for this purpose, and/or in vitro assays using expressed enzymes. Optimized P450 conditions and strains will be tested in bench top models of bioremediation. ..
  25. Pathogenesis of a novel Hantavirus from laboratory rats
    JOE SIMMONS; Fiscal Year: 2003
    ..abstract_text> ..
  26. CANCER SUSCEPTIBILITY IN AN ANIMAL MODEL
    Raymond Yeung; Fiscal Year: 2004
    ..Appreciation of these 'modifier' genes will impart new knowledge about the interplay between genes and environment during the development of complex diseases such as cancer. ..
  27. Pathobiology and Small-Molecule Inhibition of Arenavirus Infection
    Andrew Lee; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. ECOLOGY OF EMERGING ARENAVIRUSES IN SOUTHWESTERN U.S.
    CHARLES FULHORST; Fiscal Year: 2004
    ..S.; and, 5) investigate further the human health significance of North American rodent-borne arena viruses. ..
  29. Epidemiology of Yellow Fever in the Americas
    Robert Tesh; Fiscal Year: 2005
    ..Most of the work will be done in laboratories at the University of Texas Medical Branch, Center for Tropical Diseases; but a small portion will be done at the Evandro Chagas Institute in Belem, Brazil. ..
  30. PREDICTORS OF NEUROPSYCHIATRIC SLE
    ROBIN BREY; Fiscal Year: 2004
    ..The information gained will bridge important gaps in our knowledge about NS involvement in SLE and will lead to new hypothesis-driven studies of etiopathogenesis and treatment. ..
  31. Genetic Determinants of Host Susceptibility to Pulmonary Anthrax
    Jagjit Yadav; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  32. Viral determinants of hantavirus pulmonary disease in the hamster
    Charles F Fulhorst; Fiscal Year: 2010
    ..The plasmid-based genetic system could be used in future studies to develop vaccines to prevent infection or disease and to (in the face of clinical disease) mitigate the severity of HPS. ..
  33. Host response to Chlamydia genital infection in the male
    Roger Rank; Fiscal Year: 2008
    ..abstract_text> ..
  34. Cognitive Function in SLE (COGNITION)
    Robin L Brey; Fiscal Year: 2010
    ..The information that will be gained from this study is essential for the successful discovery of biological processes that impact on cognitive function in SLE that could be potentially amenable to disease-reversing therapies. ..
  35. T Cell Memory to Respiratory Viral Infections
    Shahram Salek Ardakani; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  36. In Vivo Studies of TSC-Related Tumorigenesis
    Raymond Yeung; Fiscal Year: 2008
    ..Our long-term goal is to exploit the mechanisms of these pathways in the development of clinical therapy for TSC-related disorders. ..
  37. Rapid, accurate diagnostics for arenaviral infections
    CHARLES FULHORST; Fiscal Year: 2003
    ..g., Amapari, Flexal) that were not used to develop or test the first generation assay. ..
  38. Animal models of hantavirus cardiopulmonary disease
    CHARLES FULHORST; Fiscal Year: 2006
    ..A mouse model of severe or lethal HCPS could substantively augment studies on the pathogenesis of the capillary leak that results in the life-threatening pulmonary edema HCPS. ..
  39. Candidate Gene Analysis in murine Lupus
    Chandra Mohan; Fiscal Year: 2002
    ..Significance: These experiments have the potential to uncover the identity of a lupus susceptibility gene on murine chromosome 4, that potentially impacts B-cell hyperactivity, pathogenic ANA formation. and end-organ disease. ..
  40. Psychosocial modulation of mammary carcinogenesis
    Jason Yee; Fiscal Year: 2008
    ..As such, these studies will also allow an estimation of the proportion of the racial disparity in breast cancer that can be explained by social inequalities. [unreadable] [unreadable] [unreadable] [unreadable]..
  41. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  42. VEGF regulation of surfactant proteins in preventing RSV
    DAVID MEYERHOLZ; Fiscal Year: 2005
    ....
  43. Studies of Collagen Gene Regulation in Two Murine Models
    Stephen Clark; Fiscal Year: 2005
    ....
  44. BIOLOGY AND CONTROL OF LYME DISEASE BORRELIA
    Alan Barbour; Fiscal Year: 2004
    ..burgdorferi, its transmission, and reservoir host immunize responses. The results may also have relevance for the control of other vector-bone zoonotic diseases and perhaps for development of novel methods for vaccine delivery. ..
  45. Purchase of Ventilated Caging Systems and Workstations
    Debra Hickman; Fiscal Year: 2006
    ..We currently have 5 rooms that house rodents in ventilated filter-top caging but do not have access to a workstation. ..
  46. Modulation of age-related changes in the auditory system
    JAMES WILLOTT; Fiscal Year: 2008
    ..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. [unreadable] [unreadable]..