dog diseases

Summary

Summary: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.

Top Publications

  1. doi Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis
    L Solano-Gallego
    Dept Pathology and Infectious Diseases, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Herts, UK
    Vet Parasitol 165:1-18. 2009
  2. ncbi Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 438:803-19. 2005
  3. pmc LeishVet guidelines for the practical management of canine leishmaniosis
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, London, UK
    Parasit Vectors 4:86. 2011
  4. pmc The origin and phylogeography of dog rabies virus
    Herve Bourhy
    Institut Pasteur, UPRE Lyssavirus Dynamics and Host Adaptation, World Health Organization Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, 75724 Paris Cedex 15, France
    J Gen Virol 89:2673-81. 2008
  5. doi Morphological and molecular data on the dermal microfilariae of a species of Cercopithifilaria from a dog in Sicily
    Domenico Otranto
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, 70010 Valenzano, Bari, Italy
    Vet Parasitol 182:221-9. 2011
  6. pmc Thelazia callipaeda: infection in dogs: a new parasite for Spain
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, de Madrid, Spain
    Parasit Vectors 4:148. 2011
  7. pmc The prevalence of canine Leishmania infantum infection in western China detected by PCR and serological tests
    Jun yun Wang
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People s Republic of China
    Parasit Vectors 4:69. 2011
  8. ncbi The current status of zoonotic leishmaniases and approaches to disease control
    Marina Gramiccia
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Int J Parasitol 35:1169-80. 2005
  9. doi Molecular biological aspects on canine and human mammary tumors
    P Rivera
    Center of Clinical Comparative Oncology C3O, Department of Clinical Sciences, Division of Small Animals, Swedish University of Agricultural Sciences, PO Box 7054, S 750 07, Uppsala, Sweden
    Vet Pathol 48:132-46. 2011
  10. pmc Population genetic structure of the Staphylococcus intermedius group: insights into agr diversification and the emergence of methicillin-resistant strains
    Jeanette Bannoehr
    Laboratory for Bacterial Evolution and Pathogenesis, Centre for Infectious Diseases, The Chancellor s Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland
    J Bacteriol 189:8685-92. 2007

Research Grants

Detail Information

Publications280 found, 100 shown here

  1. doi Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis
    L Solano-Gallego
    Dept Pathology and Infectious Diseases, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Herts, UK
    Vet Parasitol 165:1-18. 2009
    ..Protection against sand fly bites by topical insecticides is effective in reducing infection, and recent development of vaccines has indicated that prevention by vaccination is feasible...
  2. ncbi Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 438:803-19. 2005
    ..The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health...
  3. pmc LeishVet guidelines for the practical management of canine leishmaniosis
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, London, UK
    Parasit Vectors 4:86. 2011
    ....
  4. pmc The origin and phylogeography of dog rabies virus
    Herve Bourhy
    Institut Pasteur, UPRE Lyssavirus Dynamics and Host Adaptation, World Health Organization Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, 75724 Paris Cedex 15, France
    J Gen Virol 89:2673-81. 2008
    ..Overall, our study reveals that the stochastic processes of genetic drift and population subdivision are the most important factors shaping the global phylogeography of canid RABV...
  5. doi Morphological and molecular data on the dermal microfilariae of a species of Cercopithifilaria from a dog in Sicily
    Domenico Otranto
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, 70010 Valenzano, Bari, Italy
    Vet Parasitol 182:221-9. 2011
    ....
  6. pmc Thelazia callipaeda: infection in dogs: a new parasite for Spain
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, de Madrid, Spain
    Parasit Vectors 4:148. 2011
    ..Italy, France, Germany and Switzerland). In June 2010, the first case of canine thelaziosis was observed in central western Spain (La Vera region, Cáceres) and subsequent epidemiological investigation is reported in the present study...
  7. pmc The prevalence of canine Leishmania infantum infection in western China detected by PCR and serological tests
    Jun yun Wang
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People s Republic of China
    Parasit Vectors 4:69. 2011
    ....
  8. ncbi The current status of zoonotic leishmaniases and approaches to disease control
    Marina Gramiccia
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Int J Parasitol 35:1169-80. 2005
    ..Laboratory and field studies have shown improved efficacy of these preparations for both individual and mass protection...
  9. doi Molecular biological aspects on canine and human mammary tumors
    P Rivera
    Center of Clinical Comparative Oncology C3O, Department of Clinical Sciences, Division of Small Animals, Swedish University of Agricultural Sciences, PO Box 7054, S 750 07, Uppsala, Sweden
    Vet Pathol 48:132-46. 2011
    ..The findings in larger genomewide association analyses and cDNA expression arrays are described, and the BRCA1/BRCA2 complex is compared in detail between the 2 species...
  10. pmc Population genetic structure of the Staphylococcus intermedius group: insights into agr diversification and the emergence of methicillin-resistant strains
    Jeanette Bannoehr
    Laboratory for Bacterial Evolution and Pathogenesis, Centre for Infectious Diseases, The Chancellor s Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland
    J Bacteriol 189:8685-92. 2007
    ..pseudintermedius clones found on different continents. Taken together, these data have resolved the population genetic structure of the S. intermedius group, resulting in new insights into its ancient and recent evolution...
  11. doi Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North America: an international multicentre study
    Vincent Perreten
    Institute of Veterinary Bacteriology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 65:1145-54. 2010
    ..The aim of this study was to determine the phenotypic and genotypic resistance profiles of methicillin-resistant Staphylococcus pseudintermedius (MRSP) and to examine the clonal distribution in Europe and North America...
  12. doi Babesiosis in dogs and cats--expanding parasitological and clinical spectra
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
    Vet Parasitol 181:48-60. 2011
    ..Accurate detection and species recognition are important for the selection of the correct therapy and prediction of the course of disease...
  13. doi Expression of IFN-gamma, TNF-alpha, IL-10 and TGF-beta in lymph nodes associates with parasite load and clinical form of disease in dogs naturally infected with Leishmania (Leishmania) chagasi
    Cintia F Alves
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil
    Vet Immunol Immunopathol 128:349-58. 2009
    ..Hence, the balance of expression of IFN-gamma and TNF-alpha (protective) and IL-10 and TGF-beta (disease progression) in lymph nodes determine parasite burden and clinical expression in naturally infected dogs...
  14. doi Growth hormone receptor (GHR) RNAi decreases proliferation and enhances apoptosis in CMT-U27 canine mammary carcinoma cell line
    K M Pawłowski
    Faculty of Veterinary Medicine, Department of Physiological Sciences, Warsaw University of Life Sciences WULS, Warsaw, Poland
    Vet Comp Oncol 10:2-15. 2012
    ..This study indicates that GHR besides proliferative effect promotes growth by increasing cell survival. It can tilt the balance between proliferation and death in cancer cells...
  15. doi Transmission, reservoir hosts and control of zoonotic visceral leishmaniasis
    R J Quinnell
    Institute of Integrative and Comparative Biology, University of Leeds, Leeds LS2 9JT, UK
    Parasitology 136:1915-34. 2009
    ..Topical insecticides (deltamethrin-impregnated collars and pour-ons) have been shown to provide a high level of individual protection to treated dogs, but further community-level studies are needed...
  16. pmc Case report: First evidence of human zoonotic infection by Onchocerca lupi (Spirurida, Onchocercidae)
    Domenico Otranto
    Department of Veterinary Public Health, Universita degli Studi di Bari, Valenzano, Italy
    Am J Trop Med Hyg 84:55-8. 2011
    ..lupi should be considered in the differential diagnosis of other eye parasitic infections in humans. The role of dogs as natural hosts of O. lupi and the vectors of this zoonotic parasite need to be investigated...
  17. pmc Vector-borne helminths of dogs and humans in Europe
    Domenico Otranto
    Dipartimento di Medicina Veterinaria, Universita degli Studi di Bari, Bari, Valenzano, Italy
    Parasit Vectors 6:16. 2013
    ..In addition, this article provides the authors' opinion on some topics related to VBH that would deserve further scientific investigation...
  18. doi Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine
    P D Eckersall
    Division of Animal Production and Public Health, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow G61 1QH, UK
    Vet J 185:23-7. 2010
    ....
  19. pmc Control of visceral leishmaniasis in latin america-a systematic review
    Gustavo A S Romero
    Nucleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasilia, Brasilia, Distrito Federal, Brazil
    PLoS Negl Trop Dis 4:e584. 2010
    ....
  20. doi Classification and grading of canine mammary tumors
    M Goldschmidt
    Laboratory of Pathology and Toxicology, University of Pennsylvania, School of Veterinary Medicine, 3900 Delancey Street, Philadelphia, PA 19104, USA
    Vet Pathol 48:117-31. 2011
    ..These have been incorporated into the proposed new classification system. This article also compares the grading systems for canine mammary carcinomas and their use for prognosis, along with the histologic classification...
  21. doi Canine and feline infections by cardiopulmonary nematodes in central and southern Italy
    Angela Di Cesare
    Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, Teramo, Italy
    Parasitol Res 109:S87-96. 2011
    ..Larger surveys are necessary to gain more information on the diffusion of these parasites, especially for C. aerophila and A. vasorum, for which the actual distribution is poorly known...
  22. doi Tick-borne infections in dogs-an emerging infectious threat
    Bruno Chomel
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Parasitol 179:294-301. 2011
    ....
  23. ncbi Canine mammary gland tumors
    Karin Sorenmo
    University of Pennsylvania, School of Veterinary Medicine, Department of Clinical Studies, 3900 Delancey Street, Philadelphia, PA 19104, USA
    Vet Clin North Am Small Anim Pract 33:573-96. 2003
    ....
  24. doi Advances in the pathogenesis of canine leishmaniosis: epidemiologic and diagnostic implications
    Manolis N Saridomichelakis
    Clinic of Medicine, School of Veterinary Medicine, University of Thessaly, Karditsa, Greece
    Vet Dermatol 20:471-89. 2009
    ....
  25. doi PCR detection of Angiostrongylus vasorum in faecal samples of dogs and foxes
    Mohammad N S Al-Sabi
    Department of Agriculture and Ecology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark
    Parasitol Res 107:135-40. 2010
    ....
  26. doi Heartworm disease in animals and humans
    John W McCall
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Adv Parasitol 66:193-285. 2008
    ..repens in humans in Europe. The chapter concludes with a discussion on emerging strategies in heartworm treatment and control, highlighting the potential role of tetracycline antibiotics in adulticidal therapy...
  27. doi Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein
    Ana Paula Fernandes
    Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Vaccine 26:5888-95. 2008
    ....
  28. doi The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): from taxonomy to control
    Filipe Dantas-Torres
    Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Caixa Postal 7472, Avenida Professor Moraes Rego s n, Campus UFPE, Recife, Pernambuco, Brazil
    Vet Parasitol 152:173-85. 2008
    ..sanguineus, highlighting the potential risks associated to the improper use of acaricides, such as environmental pollution and toxicity to humans and other non-target organisms (e.g., tick predators)...
  29. pmc Zoonoses in the bedroom
    Bruno B Chomel
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Emerg Infect Dis 17:167-72. 2011
    ..The estimated percentage of pet owners who allow dogs and cats on their beds is 14%-62%. However, public health risks, including increased emergence of zoonoses, may be associated with such practices...
  30. ncbi The veterinary and public health significance of hookworm in dogs and cats in Australia and the status of A. ceylanicum
    Carlysle S Palmer
    WHO Collaborating Centre for Molecular Epidemiology of Parasitic Infections, School of Veterinary and Biomedical Sciences and Western Australian State Agricultural Biotechnology Centre, Murdoch University, Perth, Australia
    Vet Parasitol 145:304-13. 2007
    ....
  31. ncbi Chemotherapy of canine leishmaniosis
    Gad Baneth
    School of Veterinary Medicine, Hebrew University, P O Box 12, 76100, Rehovot, Israel
    Vet Parasitol 106:315-24. 2002
    ..Due to the current lack of an ultimate and effective therapy for canine leishmaniosis, new drugs, delivery systems and treatment strategies are necessary to achieve a consistent parasitological cure in infected dogs...
  32. ncbi Advantages of real-time PCR assay for diagnosis and monitoring of canine leishmaniosis
    O Francino
    Servei Veterinari de Genètica Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Parasitol 137:214-21. 2006
    ..The continuous data provided by real-time qPCR could solve the dilemma for the clinician managing cases of canine leishmaniosis by differentiating between Leishmania-infected dogs or dogs with active disease of leishmaniosis...
  33. ncbi Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission
    Orin Courtenay
    Ecology and Epidemiology Group, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    J Infect Dis 186:1314-20. 2002
    ..Mathematical modeling suggests that culling programs fail because of high incidence of infection and infectiousness, the insensitivity of the diagnostic test to detect infectious dogs, and time delays between diagnosis and culling...
  34. pmc Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal--a national serological study
    Luis Cardoso
    Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tras os Montes e Alto Douro, Vila Real, Portugal
    Parasit Vectors 5:62. 2012
    ..The present study aimed at assessing the seroprevalence of infection with or exposure to Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in dogs in Portugal...
  35. pmc Vector-borne diseases--constant challenge for practicing veterinarians: recommendations from the CVBD World Forum
    Gad Baneth
    Koret School of Veterinary Medicine, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem Rehovot, Israel
    Parasit Vectors 5:55. 2012
    ..As a result of these discussions, we, the members of the CVBD Forum have developed the following recommendations to veterinarians for the management of CVBDs...
  36. pmc Current situation of Leishmania infantum infection in shelter dogs in northern Spain
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Parasit Vectors 5:60. 2012
    ..Besides L. infantum infection, the epidemiological role of variables like sex, breed and age was also assessed...
  37. doi Canine leishmaniosis in the Old and New Worlds: unveiled similarities and differences
    Filipe Dantas-Torres
    Department of Immunology, Aggeu Magalhães Research Institute, Oswaldo Cruz Foundation, 50670 420 Recife, Pernambuco, Brazil
    Trends Parasitol 28:531-8. 2012
    ..Finally, it calls the attention of veterinary and public health authorities to standardize and improve practices for diagnosing, treating, and preventing the disease...
  38. ncbi Canine leishmaniasis
    Jorge Alvar
    WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    Adv Parasitol 57:1-88. 2004
    ....
  39. pmc MTM1 mutation associated with X-linked myotubular myopathy in Labrador Retrievers
    Alan H Beggs
    Division of Genetics and Program in Genomics, The Manton Center for Orphan Disease Research at Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14697-702. 2010
    ..These data demonstrate that XLMTM in Labrador Retrievers is a faithful genetic model of the human condition...
  40. doi Transcriptomic "portraits" of canine mammary cancer cell lines with various phenotypes
    M Krol
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences SGGW, Warsaw, Poland
    J Appl Genet 51:169-83. 2010
    ..Metastatic properties of mammary cancer cells seem to be associated with elevated expression of PGP (P glycoprotein), SEMA3B (semaphorin 3B), and STIM1 (stromal interaction molecule 1)...
  41. doi Evolution of clinical, haematological and biochemical findings in young dogs naturally infected by vector-borne pathogens
    Donato de Caprariis
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, Valenzano, BA, Italy
    Vet Microbiol 149:206-12. 2011
    ..vogeli or A. platys and Bartonella spp. co-infections. This study emphasizes the clinical difficulties associated with assigning a specific clinical sign or haematological abnormality to a particular canine vector-borne disease...
  42. pmc Use of an activity monitor to detect response to treatment in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 237:66-70. 2010
    ..To determine whether an activity monitor (AM) could be used to detect changes in activity in dogs with osteoarthritis treated with carprofen or a placebo...
  43. ncbi Impact of canine control on the epidemiology of canine and human visceral leishmaniasis in Brazil
    C B Palatnik-de-Sousa
    Department of General Microbiology, , Federal University of Rio de Janeiro, Brazil
    Am J Trop Med Hyg 65:510-7. 2001
    ....
  44. doi Association between anal sac gland carcinoma and dog leukocyte antigen-DQB1 in the English Cocker Spaniel
    J Aguirre-Hernandez
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Tissue Antigens 76:476-81. 2010
    ....
  45. pmc The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats
    Dorothee Stanneck
    Bayer Animal Health GmbH, Leverkusen, Germany
    Parasit Vectors 5:73. 2012
    ..A new polymer matrix collar has recently been developed which is registered for 8 months use in cats and dogs. The basic properties of this collar have been investigated in several in vitro and in vivo studies...
  46. doi Macrocyclic lactone resistance in Dirofilaria immitis
    Catherine Bourguinat
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Sainte Anne de Bellevue, Quebec H9X3V9, Canada
    Vet Parasitol 181:388-92. 2011
    ..3% in microfilariae that survived repeated treatments with high doses of ML anthelmintics. The data show phenotypic and genotypic evidence of ML resistance in Dirofilaria immitis...
  47. doi Prevention of endemic canine vector-borne diseases using imidacloprid 10% and permethrin 50% in young dogs: a longitudinal field study
    D Otranto
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, Valenzano, BA, Italy
    Vet Parasitol 172:323-32. 2010
    ..The results demonstrate that ImPer preventive treatment against arthropods protects autochthonous and naïve beagle dogs against CVBD-causing pathogens...
  48. ncbi Current status of human rabies transmitted by dogs in Latin America
    Maria Cristina Schneider
    Veterinary Public Health Unit, Pan American Health Organization, Washington, DC 20037 2895, USA
    Cad Saude Publica 23:2049-63. 2007
    ..Samples sent for rabies testing represent 0.05% of the estimated canine population (range: 0.001 to 0.2%). The countries are quite close to achieving the goal...
  49. ncbi Histological grading and prognosis in dogs with mammary carcinomas: application of a human grading method
    M Karayannopoulou
    Department of Clinical Studies, School of Veterinary Medicine, Aristotle University of Thessaloniki, St Voutyra 11, 546 27, Thessaloniki, Greece
    J Comp Pathol 133:246-52. 2005
    ..001). Routine use of this human grading method would help the clinician to make a more accurate prognosis in the interests of post-surgical management in dogs with mammary carcinomas...
  50. ncbi Tick-borne infectious diseases of dogs
    S E Shaw
    Dept of Clinical Veterinary Sciences, University of Bristol, Langford House, Langford, Bristol, UK BS40 5DU
    Trends Parasitol 17:74-80. 2001
    ....
  51. ncbi Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs
    Michael K Rust
    Department of Entomology, University of California, Riverside, CA 92521 0314, USA
    Trends Parasitol 21:232-6. 2005
    ..Surveys have yet to reveal the development of insecticide resistance to these chemical compounds. Extending the longevity of these effective host-targeted therapies should be a major goal of the veterinary community...
  52. doi Heartworm and Wolbachia: therapeutic implications
    J W McCall
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA
    Vet Parasitol 158:204-14. 2008
    ..Preliminary observations suggest that administration of DOXY+IVM for several months prior to (or without) MEL will eliminate adult HW with less potential for severe thromboembolism than MEL alone...
  53. doi Psychometric testing of the Helsinki chronic pain index by completion of a questionnaire in Finnish by owners of dogs with chronic signs of pain caused by osteoarthritis
    Anna K Hielm-Björkman
    Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, FIN 00014, Finland
    Am J Vet Res 70:727-34. 2009
    ..To determine the validity, reliability, and sensitivity of a published chronic pain index by completion of a questionnaire in Finnish by owners of dogs with chronic signs of pain caused by osteoarthritis...
  54. ncbi Failure of a multi-subunit recombinant leishmanial vaccine (MML) to protect dogs from Leishmania infantum infection and to prevent disease progression in infected animals
    L Gradoni
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Vaccine 23:5245-51. 2005
    ..We conclude that vaccination with MML is not effective to prevent leishmaniasis infection and disease progression in dogs under field conditions...
  55. ncbi Cerebellar cortical degeneration with selective granule cell loss in Bavarian mountain dogs
    T Flegel
    Department of Small Animal Medicine, University of Leipzig, An den Tierkliniken 23, 04103 Leipzig, Germany
    J Small Anim Pract 48:462-5. 2007
    ....
  56. ncbi Ixodid tick species attaching to dogs in Hungary
    Gábor Földvári
    Department of Parasitology and Zoology, Faculty of Veterinary Science, St Istvan University, P O Box 2, Budapest H 1400, Hungary
    Vet Parasitol 129:125-31. 2005
    ..Our data contribute to the understanding of geographical and seasonal distribution of ixodid tick species infesting dogs in Hungary. The implication of these data, for the risk of canine tick borne diseases is discussed...
  57. ncbi The efficacy of collars impregnated with flumethrin and propoxur against experimental infestations of adult Rhipicephalus sanguineus on dogs
    L J Fourie
    Department of Zoology and Entomology, University of the Free State, PO Box 339, Bloemfontein 9301, South Africa
    J S Afr Vet Assoc 74:123-6. 2003
    ..The mean tick counts on the 2 groups of collared dogs did not differ significantly (P < 0.0001) for any of the assessment days...
  58. doi A SYBR green real-time PCR assay for the detection of the nematode Angiostrongylus vasorum in definitive and intermediate hosts
    R Jefferies
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
    Vet Parasitol 166:112-8. 2009
    ..Real-time quantitative PCR offers a more efficient means of detecting A. vasorum infection with a lower limit of detection than traditional diagnostic tests, and it therefore has important clinical and epidemiological applications...
  59. doi Prevalence of flea infestation in dogs and cats in Hungary combined with a survey of owner awareness
    R Farkas
    Department of Parasitology and Zoology, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary
    Med Vet Entomol 23:187-94. 2009
    ..Very few owners reported having attempted to kill fleas in their animals' environment; instead, they believed that fleas were acquired from other cats or dogs...
  60. doi Evidence of inheritance of intrahepatic portosystemic shunts in Irish Wolfhounds
    F G van Steenbeek
    Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Vet Intern Med 23:950-2. 2009
    ..The etiogenesis of congenital portosystemic shunt in dogs is not understood. In Irish Wolfhounds, intrahepatic portosystemic shunt (IHPSS) is thought to be hereditary, but the mode of inheritance is unknown...
  61. doi Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes
    Bruno L Travi
    University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Trop Med Hyg 81:994-1003. 2009
    ..On the basis of the data obtained from this study, a sample size analysis using different endpoints for future vaccine trials is described...
  62. doi Flea and tick control in the 21st century: challenges and opportunities
    Michael Wayne Dryden
    Department of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, KS 66506, USA
    Vet Dermatol 20:435-40. 2009
    ..These factors probably cause most real and perceived product failures...
  63. pmc Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 233:1278-83. 2008
    ..To determine whether the Canine Brief Pain Inventory (CBPI) can detect changes in dogs with osteoarthritis treated with an NSAID or a placebo...
  64. ncbi Seroprevalence of Leishmania infantum in northwestern Spain, an area traditionally considered free of leishmaniasis
    Inmaculada Amusategui
    College of Veterinary Medicine, Universidad Complutense de Madrid, Spain
    Ann N Y Acad Sci 1026:154-7. 2004
    ..On the other hand, companion dogs were significantly less likely to acquire the disease than sheep dogs, hunting dogs, and those from kennels...
  65. ncbi Isotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in Brazilian dogs naturally infected by Leishmania (Leishmania) chagasi
    Alexandre B Reis
    Laboratorio de Imunologia Celular e Molecular, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
    Vet Immunol Immunopathol 112:102-16. 2006
    ..The association between clinical status, Ig profile and the tissue parasitism support a novel investigation on the impact of humoral immune response and susceptibility/resistance mechanism during ongoing CVL...
  66. ncbi Value of two PCR methods for the diagnosis of canine visceral leishmaniasis and the detection of asymptomatic carriers
    L Lachaud
    Laboratoire de Parasitologie Mycologie et Centre National de Référence sur les Leishmanioses, Faculte de Medecine, Montpellier, France
    Parasitology 125:197-207. 2002
    ..A strategy best adapted for prevalence surveys might combine serology and highly sensitive PCR on peripheral blood...
  67. ncbi Density of tumor-associated macrophages (TAMs) and expression of their growth factor receptor MCSF-R and CD14 in canine mammary adenocarcinomas of various grade of malignancy and metastasis
    M Krol
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences WULS, Nowoursynowska 159, 02 776 Warsaw, Poland
    Pol J Vet Sci 14:3-10. 2011
    ..Hence, these molecules play a role in tumor progression, metastasis and microenvironment interactions. These results show that in dogs we should treat the tumor as a whole organ rather than just try to eliminate the cancer cells...
  68. doi Seasonal dynamics of the brown dog tick, Rhipicephalus sanguineus, on a confined dog population in Italy
    V Lorusso
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, Valenzano, Bari, Italy
    Med Vet Entomol 24:309-15. 2010
    ..This information should be taken into account when planning control programmes against this tick species and the pathogens it transmits...
  69. doi Venereal transmission of canine visceral leishmaniasis
    Fabiana L Silva
    Departamento de Clinica e Cirurgia Veterinarias, Escola de Veterinária da Universidade Federal de Minas Gerais 31270 901 Belo Horizonte, MG, Brazil
    Vet Parasitol 160:55-9. 2009
    ..These data support the notion that L. chagasi may be sexually transmitted from naturally infected dogs to susceptible bitches in the absence of the biological insect vector...
  70. doi Emerging trends in the seroprevalence of canine leishmaniasis in the Madrid region (central Spain)
    R Galvez
    Servicio de Parasitologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo s n, Majadahonda, 28220 Madrid, Spain
    Vet Parasitol 169:327-34. 2010
    ..Further studies designed to explain this trend should attempt to correlate sand fly densities and CanL seroprevalences with climate, land use and human changes...
  71. pmc A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility
    Michael J Smout
    James Cook University, Cairns, Australia
    PLoS Negl Trop Dis 4:e885. 2010
    ..Currently, drug effect is assessed by observing motility or development of parasites using laborious, subjective, low-throughput methods...
  72. doi Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs
    Shona Hiedi Wood
    Department of Veterinary Pathology, Faculty of Veterinary Science, The University of Liverpool, Liverpool, L69 3ZJ, UK
    Immunogenetics 61:765-72. 2009
    ..Given the clinical heterogeneity within this condition and the likelihood that the relative genetic effect sizes are small, greater sample sizes and further studies will be required...
  73. pmc Diagnosis of canine vector-borne diseases in young dogs: a longitudinal study
    Domenico Otranto
    Department of Veterinary Public Health and Animal Sciences, Faculty of Veterinary Medicine, Valenzano, Bari, Italy
    J Clin Microbiol 48:3316-24. 2010
    ....
  74. doi Canine leishmaniosis in the United Kingdom: a zoonotic disease waiting for a vector?
    Susan E Shaw
    Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, North Somerset BS40 5DU, UK
    Vet Parasitol 163:281-5. 2009
    ..These data confirm that a potentially significant reservoir of infected dogs is resident in areas where future climatic conditions may support introduction of competent vectors...
  75. doi Methods for diagnosis of canine leishmaniasis and immune response to infection
    C Maia
    Unidade de Leishmanioses, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    Vet Parasitol 158:274-87. 2008
    ..In this paper we review the advantages and shortcomings of the available procedures for CanL diagnosis in the different phases, e.g. pre-patent and patent period of the infection and methods to determine the related immune response...
  76. ncbi Decreased sensitivity to meglumine antimoniate (Glucantime) of Leishmania infantum isolated from dogs after several courses of drug treatment
    M Gramiccia
    Laboratorio di Parassitologia, , Rome, Italy
    Ann Trop Med Parasitol 86:613-20. 1992
    ..This result underlines the futility and danger of repeated antimonial treatments of dogs with signs of leishmaniasis, as these may produce a permanent reservoir of parasites unsusceptible to the drugs in human clinical use...
  77. pmc The potential impact of density dependent fecundity on the use of the faecal egg count reduction test for detecting drug resistance in human hookworms
    Andrew C Kotze
    CSIRO Livestock Industries, St Lucia, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 2:e297. 2008
    ....
  78. ncbi Evaluation of the efficacy of a topically administered combination of imidacloprid and permethrin against Phlebotomus perniciosus in dog
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda Puerta de Hierro s n, 28040 Madrid, Spain
    Vet Parasitol 143:375-9. 2007
    ....
  79. ncbi Treatment of canine Old World visceral leishmaniasis: a systematic review
    Chiara Noli
    Ospedale Veterinario Cuneese, Via Cuneo 52 N, 12011 Borgo S Dalmazzo CN, Italy
    Vet Dermatol 16:213-32. 2005
    ..Evaluation of articles on repellent measures against sand fly vectors of leishmaniasis provided good evidence for recommending deltamethrin collars and fair evidence for recommending spot-on permethrin...
  80. pmc Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology
    L Solano-Gallego
    Departament de Farmacologia i Terapeutica, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    J Clin Microbiol 39:560-3. 2001
    ..The results showed that the majority of dogs living in an area where canine leishmaniasis is endemic are infected by Leishmania and that the prevalence of infection is much greater than the prevalence of overt Leishmania-related disease...
  81. ncbi Repellent efficacy of a combination containing imidacloprid and permethrin against sand flies (Phlebotomus papatasi) in dogs
    N Mencke
    Bayer AG, BHC Business Group Animal Health, D 51368 Leverkusen, Germany
    Parasitol Res 90:S108-11. 2003
    ..0% (day 1), 46.2% (day 8), 42.6% (day 15), 35.2% (day 22) and 29.3% (day 29). The study demonstrated the high repellent potential of the imidacloprid / permethrin combination, thus protecting dogs from sand fly bites...
  82. ncbi Canine leishmaniasis: epidemiological risk and the experimental model
    Javier Moreno
    WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologi a, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Spain
    Trends Parasitol 18:399-405. 2002
    ..Such studies are essential to determine the basis of the canine protective immune response and to establish a laboratory model, a significant aspect for the development of vaccines against canine leishmaniasis...
  83. ncbi Expanded repeat in canine epilepsy
    Hannes Lohi
    The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Science 307:81. 2005
    ..Clinicopathologic characterization establishes affected animals as a model for Lafora disease, the most severe teenage-onset human epilepsy...
  84. ncbi Infectivity of seropositive dogs, showing different clinical forms of leishmaniasis, to Lutzomyia longipalpis phlebotomine sand flies
    Erika Monteiro Michalsky
    Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima, 1715, Barro Preto, Belo Horizonte, CEP 30190 002, MG, Brazil
    Vet Parasitol 147:67-76. 2007
    ..The lower infectivity rates of dogs displaying any of the last two clinical forms of leishmaniasis, however, must be taken into account in the epidemiology of CVL...
  85. ncbi Visceral leishmaniasis in a New York foxhound kennel
    Amanda A Gaskin
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27603, USA
    J Vet Intern Med 16:34-44. 2002
    ..Transmission of Leishmania spp. in kennel outbreaks may involve exposure to an insect vector, direct transmission, or vertical transmission...
  86. ncbi Canine leishmaniasis: clinical, parasitological and entomological follow-up after chemotherapy
    J Alvar
    Laboratorio de Referencia de Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain
    Ann Trop Med Parasitol 88:371-8. 1994
    ..Some dogs from both the 'asymptomatic' and 'symptomatic' groups became infective to sandflies several months post-treatment...
  87. doi The northward spread of leishmaniasis in Italy: evidence from retrospective and ongoing studies on the canine reservoir and phlebotomine vectors
    Michele Maroli
    Istituto Superiore di Sanita, Rome, Italy
    Trop Med Int Health 13:256-64. 2008
    ..Northern continental Italy is now focally endemic for VL and a moderate risk for human disease does exist, although the intensity of transmission seems to be lower than in traditional settings of Mediterranean VL...
  88. ncbi The FML-vaccine (Leishmune) against canine visceral leishmaniasis: a transmission blocking vaccine
    Elvira M Saraiva
    Instituto de Microbiologia, Prof Paulo de Góes, Universidade Federal do Rio de Janeiro UFRJ, CCS, Cidade Universitaria, Ilha do Fundao, Caixa Postal 68040, CEP 21941 590, Rio de Janeiro, RJ, Brazil
    Vaccine 24:2423-31. 2006
    ..7%) in the vaccine group. Our results disclosed that the Leishmune vaccine is a TBV, and that the dog antibodies present in sera, even 12 months after vaccination, lead to a significant effective protection of 79.3%...
  89. doi A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse
    Edward E Patterson
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota 55108, USA
    Nat Genet 40:1235-9. 2008
    ....
  90. doi Emergence of canine ocular Thelaziosis caused by Thelazia callipaeda in southern Switzerland
    F Malacrida
    Institute of Parasitology, Vetsuisse Faculty, University of Zurich, Winterthurerstr 266a, CH 8057 Zurich, Switzerland
    Vet Parasitol 157:321-7. 2008
    ..Young and small sized dogs were significantly less involved than large animals and over 3 years of age. The results indicate that thelaziosis is endemic in that area...
  91. pmc Detection and molecular characterization of a canine norovirus
    Vito Martella
    University of Bari, Bari, Italy
    Emerg Infect Dis 14:1306-8. 2008
    ..We identified a novel calicivirus in a pup with enteritis. The isolate was related genetically (90.1% aa identity in the capsid protein) to a lion norovirus strain...
  92. doi Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis
    Thierry Olivry
    Department of Clinical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet Dermatol 21:233-48. 2010
    ..Allergen-specific immunotherapy should be offered, whenever feasible, in an attempt to prevent recurrence of clinical signs upon further exposure to environmental allergens to which the patient is hypersensitive...
  93. doi Dog-associated risk factors for human plague
    L Hannah Gould
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Bacterial Diseases Branch, Fort Collins, CO, USA
    Zoonoses Public Health 55:448-54. 2008
    ..046). Our findings suggest that dogs may facilitate the transfer of fleas into the home and that activities with close extended contacts with dogs may increase the risk of plague infection...
  94. pmc A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a Dachshund
    Douglas N Sanders
    Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO, USA
    Mol Genet Metab 100:349-56. 2010
    ..736_737insC mutation; whereas, 127 unrelated Dachshunds were homozygous for the wild-type allele. This is the first reported instance of canine NCL caused by a mutation in PPT1...
  95. doi Expression and significance of PTEN and VEGF in canine mammary gland tumours
    C W Qiu
    College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    Vet Res Commun 32:463-72. 2008
    ..Reduced expression of PTEN might be involved in carcinogenesis and progression of canine breast cancer by up-regulating the VEGF expression to enhance angiogenesis...
  96. doi Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Vet Dermatol 20:397-404. 2009
    ..Miltefosine, in combination with allopurinol, offers a safe, convenient and effective alternative treatment option for canine leishmaniosis compared to the reference therapy...
  97. doi Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex
    Maria Wilbe
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Biomedical Centre, Uppsala, Sweden
    Nat Genet 42:250-4. 2010
    ....
  98. doi Isolation of Toxoplasma gondii from animals in Durango, Mexico
    J P Dubey
    Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Beltsville Agricultural Research Center, United States Department of Agriculture, Beltsville, Maryland 20705 2350, USA
    J Parasitol 95:319-22. 2009
    ..One genotype (the 4 chicken isolates) belongs to the clonal Type III lineage, three genotypes were reported in previous reports, and 1 genotype is unique...
  99. doi Toxoplasma gondii: Evidence for the transmission by semen in dogs
    Tiago Pereira Arantes
    CPPAR Animal Health Research Center, UNESP, Jaboticabal, Sao Paulo, Brazil
    Exp Parasitol 123:190-4. 2009
    ..Several T. gondii cysts were detected in the brains of four offspring. These results suggest that T. gondii can be sexually transmitted in domestic dogs...
  100. doi Tissue distribution of Leishmania chagasi and lesions in transplacentally infected fetuses from symptomatic and asymptomatic naturally infected bitches
    Kristel Kegler Pangrazio
    Departamento de Ciências Patológicas, Facultad de Ciencias Veterinarias, Universidad Nacional de Asuncion, Ruta Mcal Estigarribia km 10, San Lorenzo, Paraguay
    Vet Parasitol 165:327-31. 2009
    ..Together these findings indicate a high frequency of transplacental transmission and no differences in the potential of transmission when symptomatic were compared to asymptomatic pregnant bitches...
  101. pmc Transmission dynamics and economics of rabies control in dogs and humans in an African city
    J Zinsstag
    Swiss Tropical Institute, PO Box, CH 4002 Basle, Switzerland
    Proc Natl Acad Sci U S A 106:14996-5001. 2009
    ..Beyond a time-frame of 7 years, it appears to be more cost-effective to combine parenteral dog-vaccination campaigns with human PEP compared to human PEP alone...

Research Grants99

  1. Transcription Regulation and Biological Function of NAG1
    SEUNG BAEK; Fiscal Year: 2005
    ..Cancer and inflammation are certainly environmentally relevant problems and thus this project will provide new clues to aid in the understanding of how these drugs alter tumor development. ..
  2. AUTOSOMAL MECHANISMS OF TESTIS INDUCTION
    VICKI MEYERS WALLEN; Fiscal Year: 2005
    ..At the end of this grant period, we will have identified the gene causing this disorder and the step in the testis pathway that is altered by the mutation in timing, quantity, or location of gene expression. ..
  3. Enteric flora modulates the development of colitis
    Albert Jergens; Fiscal Year: 2007
    ..g., graduate students and postdoctoral fellow). There are ample opportunities to attend seminars, journal clubs and work-in-progress research meetings during which the applicant can become engaged in scientific discussions. ..
  4. Measure Validation and RCT- Dog Bone Cancer Pain Model
    Dorothy Brown; Fiscal Year: 2007
    ....
  5. Diagnostic assays for Borrelia Ionestari
    Susan Little; Fiscal Year: 2005
    ..causing disease in people and, ultimately, a more robust understanding of the role of B. lonestari as a human pathogen. Improved diagnosis of human B. lonestari infection should result. ..
  6. Tissue engineered osteochondral patella resurfacing
    James Cook; Fiscal Year: 2007
    ....
  7. Natural History of Borrelia lonestari
    Susan Little; Fiscal Year: 2006
    ..S., enhancing public health efforts in those areas where people are risk of infection; reduction in human disease from these pathogens should result. ..
  8. Infectious Disease Training in Clinical Investigation
    James Johnson; Fiscal Year: 2007
    ....
  9. Molecular Mechanism of Polarized Cubilin Expression
    JOHN FYFE; Fiscal Year: 2004
    ..Results of these efforts are expected to open a window onto a new aspect of nutrient absorption and membrane receptor biology. ..
  10. SPONTANEOUS CANINE MODELS FOR CANCER GENE DISCOVERY
    Matthew Breen; Fiscal Year: 2010
    ..We propose that Man's best friend will provide the keys to unlocking some of nature's most intriguing puzzles about cancer. ..
  11. Helicobacter pylori: Pathogenesis and Virulence
    Kenneth Simpson; Fiscal Year: 2005
    ....
  12. SPONTANEOUS CANINE MODELS FOR CANCER GENE DISCOVERY
    Matthew Breen; Fiscal Year: 2007
    ..We propose that Man's best friend will provide the keys to unlocking some of nature's most intriguing puzzles about cancer. ..
  13. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  14. The molecular basis for an animal model of inherited hyperuricosuria
    Danika Bannasch; Fiscal Year: 2007
    ..The elucidation of a novel gene function should provide new avenues of investigation for the treatment of the human condition. ..
  15. MOLECULAR PATHOGENESIS OF FELINE SPINAL MUSCULAR ATROPHY
    JOHN FYFE; Fiscal Year: 2002
    ..Initial candidate genes will be those implicated in human SMA, but otherwise a comparative positional-candidate gene approach will be taken. ..
  16. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
    ....
  17. Trypanosoma cruzi-elicited cardiac hypertrophy
    Christine Petersen; Fiscal Year: 2004
    ..abstract_text> ..
  18. Canine Brain Tumors - A New Model for Gene Discovery
    Matthew Breen; Fiscal Year: 2006
    ..Characterization of these genetic loci will help to improve the definition of molecular risk and prognosis of human and canine brain tumors, with a potentially major impact on human health. ..
  19. Nipah Virus Marker Vaccine and Companion Diagnostic Test
    James Roth; Fiscal Year: 2005
    ..abstract_text> ..
  20. Visual cycle in human photoreceptor and RPE disease
    Artur V Cideciyan; Fiscal Year: 2010
    ..Mutations in ABCA4 gene cause one of the most common forms of retinal degeneration and the goal of the proposed research is to define the subset of patients with ABCA4 disease who are likely to benefit from gene replacement therapy. ..
  21. Regulation of the survival motor neuron gene
    CHARLOTTE SUMNER; Fiscal Year: 2007
    ....
  22. Pilot Study--Cox2 Inhibitor in Invasive Bladder Cancer
    DEBORAH KNAPP; Fiscal Year: 2002
    ..abstract_text> ..
  23. MURINE MODEL FOR MONKEY B VIRUS INFECTION
    JERRY RITCHEY; Fiscal Year: 2004
    ..abstract_text> ..
  24. Visual cycle in human photoreceptor and RPE disease
    ARTUR CIDECIYAN; Fiscal Year: 2007
    ..The long-term goal of the research program is to unravel the pathophysiologic mechanisms in human hereditary retinal degenerations, contribute to the design of mechanism-specific therapies, and develop means to test their effectiveness. ..
  25. Interdisciplinary Research Training for Veterinarians
    Lisa Freeman; Fiscal Year: 2007
    ..These evaluations, continued refinement, and the commitment of the program faculty will help to ensure that this becomes a self-sustaining program. ..
  26. Proteomic Discovery of Biomaterial Antigens
    E Orton; Fiscal Year: 2007
    ..e. tissue engineering). This application provides information about immune rejection of biomaterials that must be better understood before animal tissues can be used in tissue engineering. ..
  27. Influence of cell-bound Stx on cytokine production
    SHANNON HOSTETTER; Fiscal Year: 2007
    ....
  28. VISUAL CYCLE IN HUMAN PHOTORECEPTOR AND RPE DISEASE
    ARTUR CIDECIYAN; Fiscal Year: 2003
    ....
  29. US with Submicron Bubbles for Sentinel Node Detection
    Erik Wisner; Fiscal Year: 2004
    ..Successful completion of this study will lead to an alternative method for intra-operative sentinel node localization that may obviate many of the limitations of current techniques. ..
  30. ITO IN DOGS WITH INHERITED VENTRICULAR ARRHYTHMIAS
    Bruce Kornreich; Fiscal Year: 2005
    ..abstract_text> ..
  31. Muscle and neuromuscular junctions in spinal muscular atrophy
    CHARLOTTE SUMNER; Fiscal Year: 2009
    ..These studies will provide important insights about what tissue and molecules are necessary to target therapeutically in SMA and will therefore guide future efforts to develop treatment for this disease. ..
  32. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Ferreira; Fiscal Year: 2009
    ....
  33. Developing Avirulent Rabies Virus Vaccines
    Zhen F Fu; Fiscal Year: 2010
    ..Such characterists will make these recombinant RV vaccines particularly suitable for post-exposure treatment. ..
  34. Alpha-actinins in normal and diseased muscle
    Alan H Beggs; Fiscal Year: 2010
    ..Our results may also lead to insights into the role(s) that alpha-actinin genotypes may play in modulating and/or causing human neuromuscular disease. ..
  35. c-Kit Mutations and Their Role in Tumor Biology
    Cheryl London; Fiscal Year: 2005
    ..abstract_text> ..
  36. MRI, MIT, and MRS of MPS VII and Krabbe Disease
    Charles Vite; Fiscal Year: 2003
    ..x0a; ..
  37. ALPHA ACTININS IN NORMAL AND DISEASED MUSCLE
    Alan Beggs; Fiscal Year: 2000
    ..These experiments will also increase our understanding of alpha-actinin function and identify new interactions with existing and novel muscle proteins at the Z-line and elsewhere. ..
  38. Developing Avirulent Rabies Virus Vaccines
    Zhen Fu; Fiscal Year: 2004
    ..If the further attenuated rabies viruses no longer causes diseases in animals at any age and by any route of inoculation, yet remain immunoqenic, they can be developed as modified live rabies vaccines for humans and animals. ..
  39. Comparison of US and European Babesia divergens Isolates
    Patricia Holman; Fiscal Year: 2004
    ..The molecular aspects may provide information that will be useful in future efforts to devise diagnostic tests. ..
  40. Gene Transfer Therapy for Alport Syndrome
    George Lees; Fiscal Year: 2007
    ..It will also lay the foundation for gene transfer therapy of other glomerular iseases. ..
  41. Gene Therapy of Autosomal Recessive RP
    Simon Petersen Jones; Fiscal Year: 2006
    ..abstract_text> ..
  42. TRANSMISSION ELECTRON MICROSCOPE
    Martin Katz; Fiscal Year: 2006
    ..Broadening the user base will help make the cost per user of maintaining the instrument as low as possible. ..
  43. ANTIGEN PRESENTATION IN MALARIA INFECTION
    Anne Avery; Fiscal Year: 2002
    ..This is particularly important when planning vaccine strategies for endemic areas, where vaccines are likely to already harbor a malaria infection which could alter the way their immune system handles antigen. ..
  44. Alpha-actinins in normal and diseased muscle
    Alan Beggs; Fiscal Year: 2007
    ..Our results may also lead to insights into the role(s) that alpha-actinin genotypes may play in modulating and/or causing human neuromuscular disease. ..
  45. SARCOMERIC PROTEINS IN NORMAL AND DISEASED MUSCLE
    Alan Beggs; Fiscal Year: 2005
    ..Success in this project will enable accurate diagnostic and prognostic testing for all NM patients as well as shed new light on the structure and functions of normal and abnormal Z lines and thin filaments in skeletal muscle. ..
  46. Vaccine induced resistance against E. granulosus in dogs
    Wenbao Zhang; Fiscal Year: 2007
    ..granulosus infection by vaccination with the recombinant proteins. We will test humoral and cellular responses generated during vaccination to determine possible correlations of the immune parameters with protection. ..