borna disease

Summary

Summary: An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.

Top Publications

  1. pmc TNF-overexpression in Borna disease virus-infected mouse brains triggers inflammatory reaction and epileptic seizures
    Katharina Kramer
    Department of Pathology, University of Veterinary Medicine, Hannover, Germany
    PLoS ONE 7:e41476. 2012
  2. ncbi Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus
    C Herden
    Institut fur Pathologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Neuropathol Appl Neurobiol 31:512-21. 2005
  3. pmc Borna disease virus infects human neural progenitor cells and impairs neurogenesis
    Dragan Brnic
    INRA, Anses, ENVA, UMR 1161, Maisons Alfort, France
    J Virol 86:2512-22. 2012
  4. pmc Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice
    Markus Hofer
    Abteilung Neuropathologie, Institut für Medizinische and Hygiene, Universitat Freiburg, Freiburg, Germany
    Am J Pathol 165:949-58. 2004
  5. pmc Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity
    Christine M A Prat
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan and Université Paul Sabatier, Toulouse, France
    PLoS Pathog 5:e1000425. 2009
  6. pmc Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 78:3621-32. 2004
  7. ncbi Development of a real-time RT-PCR assay for improved detection of Borna disease virus
    Jonas Johansson Wensman
    Joint Research and Development Division in Virology of National Veterinary Institute SVA, Swedish University of Agricultural Sciences SLU, Uppsala, Sweden
    J Virol Methods 143:1-10. 2007
  8. ncbi Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus
    Marylou V Solbrig
    Department of Neurology and Pharmacology, University of California at Irvine, 3107 Gillespie Neuroscience Research Building, Irvine, CA 92697 4292, USA
    Pharmacol Biochem Behav 74:777-87. 2003
  9. ncbi Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum
    Mikhail V Ovanesov
    Division of Neurobiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 13:185-94. 2007
  10. ncbi Postnatal weight gain inhibition does not account for neurobehavioral consequences of neonatal Borna disease virus infection
    David M Dietz
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Physiol Behav 80:359-66. 2003

Research Grants

Detail Information

Publications183 found, 100 shown here

  1. pmc TNF-overexpression in Borna disease virus-infected mouse brains triggers inflammatory reaction and epileptic seizures
    Katharina Kramer
    Department of Pathology, University of Veterinary Medicine, Hannover, Germany
    PLoS ONE 7:e41476. 2012
    Proinflammatory state of the brain increases the risk for seizure development. Neonatal Borna disease virus (BDV)-infection of mice with neuronal overexpression of tumor necrosis factor-α (TNF) was used to investigate the complex ..
  2. ncbi Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus
    C Herden
    Institut fur Pathologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Neuropathol Appl Neurobiol 31:512-21. 2005
    Experimental infection of Lewis rats with Borna disease virus (BDV) causes an immune-mediated nonpurulent meningoencephalitis...
  3. pmc Borna disease virus infects human neural progenitor cells and impairs neurogenesis
    Dragan Brnic
    INRA, Anses, ENVA, UMR 1161, Maisons Alfort, France
    J Virol 86:2512-22. 2012
    ..The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms...
  4. pmc Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice
    Markus Hofer
    Abteilung Neuropathologie, Institut für Medizinische and Hygiene, Universitat Freiburg, Freiburg, Germany
    Am J Pathol 165:949-58. 2004
    ..Infection with noncytolytic Borna disease virus (BDV) did not affect wild-type mice but accelerated disease of IL-12 transgenic mice...
  5. pmc Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity
    Christine M A Prat
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan and Université Paul Sabatier, Toulouse, France
    PLoS Pathog 5:e1000425. 2009
    ..b>Borna disease virus (BDV) represents an attractive model system to analyze the molecular mechanisms whereby a virus can ..
  6. pmc Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 78:3621-32. 2004
    The nucleoprotein (N) of Borna disease virus (BDV) is the major target of the disease-inducing antiviral CD8 T-cell response in the central nervous system of mice...
  7. ncbi Development of a real-time RT-PCR assay for improved detection of Borna disease virus
    Jonas Johansson Wensman
    Joint Research and Development Division in Virology of National Veterinary Institute SVA, Swedish University of Agricultural Sciences SLU, Uppsala, Sweden
    J Virol Methods 143:1-10. 2007
    b>Borna disease virus (BDV) is a non-segmented, negative-stranded RNA virus, which infects cells of the central nervous system (CNS) in many different species...
  8. ncbi Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus
    Marylou V Solbrig
    Department of Neurology and Pharmacology, University of California at Irvine, 3107 Gillespie Neuroscience Research Building, Irvine, CA 92697 4292, USA
    Pharmacol Biochem Behav 74:777-87. 2003
    b>Borna Disease Virus (BDV) is a neurotropic RNA virus that is worldwide in distribution, causing movement and behavior disorders in a wide range of animal species...
  9. ncbi Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum
    Mikhail V Ovanesov
    Division of Neurobiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 13:185-94. 2007
    The authors evaluated a role of glutamate (GLU) excitotoxicity in neonatal Borna disease virus (BDV) infection-associated neuronal injury by measuring extracellular levels of GLU in the striatum of 70-day-old Fischer344 rats using in ..
  10. ncbi Postnatal weight gain inhibition does not account for neurobehavioral consequences of neonatal Borna disease virus infection
    David M Dietz
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Physiol Behav 80:359-66. 2003
    Neonatal Borna disease virus (BDV) infection of the rat's brain produces neurodevelopmental damage similar to some pathological and clinical features of human developmental disorders, e.g., autism and schizophrenia...
  11. ncbi Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats
    M V Pletnikov
    Laboratory of Pediatric and Respiratory Viral Diseases, CBER, FDA, Bethesda, MD 20892, USA
    Physiol Behav 66:823-31. 1999
    Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum...
  12. ncbi Gene expression of the TGF-beta family in rat brain infected with Borna disease virus
    Yoshii Nishino
    Laboratory of Veterinary Immunology, Azabu University School of Veterinary Medicine, Sagamihara 229 8501, Japan
    Microbes Infect 11:737-43. 2009
    CRNP5, a variant of Borna disease virus (BDV), has stronger pathogenesis in rats than the related variant CRP3, although only 4 amino acids in the whole genome are different...
  13. ncbi Sequence characterization of human Borna disease virus
    J C de La Torre
    Viral Immunology Laboratory, Scripps Research Institute 92037 CA, USA
    Virus Res 44:33-44. 1996
    b>Borna disease virus (BDV) causes a central nervous system disease in several vertebrate animal species, which is manifest by behavioral abnormalities...
  14. pmc Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12
    Gregor Friedl
    Abteilung Neuropathologie, Pathologisches Institut, Universitat Freiburg, D 79106 Freiburg, Germany
    J Virol 78:1212-8. 2004
    b>Borna disease virus (BDV) induces a nonpurulent CD4- and CD8-T-cell-dependent meningoencephalitis in susceptible animals...
  15. ncbi The use of peptide arrays for the characterization of monospecific antibody repertoires from polyclonal sera of psychiatric patients suspected of infection by Borna Disease Virus
    Martin Schwemmle
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Mol Divers 8:247-50. 2004
    b>Borna Disease Virus (BDV) is suspected to infect humans and to be associated with psychiatric disorders. To this date, BDV-reactive antibodies provide the only reliable markers to diagnose human BDV infection...
  16. ncbi Neurological disorder after Borna disease virus infection in the absence of either interferon-gamma, Fas, inducible NO synthase, or chemokine receptor CXCR3
    Jürgen Hausmann
    Department of Virology, University of Freiburg, Freiburg, Germany
    Viral Immunol 17:79-85. 2004
    b>Borna disease virus (BDV) can induce severe neurological disorder in Lewis rats and MRL mice. Antiviral CD8 T cells have been shown to be the mediators of disease in these animals...
  17. pmc Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant
    Marco Henkel
    Institute of Immunology, Federal Research Centre for Virus Diseases of Animals, Tuebingen, Germany
    J Virol 79:314-25. 2005
    ..Orf virus strain D1701 was used to generate a recombinant virus (D1701-VrVp40) expressing nucleoprotein p40 of Borna disease virus, which represents a major antigen for the induction of a Borna disease virus-specific humoral and ..
  18. ncbi [The neuropathogenesis of Borna disease virus infection]
    K Tomonaga
    Department of Virology, Research Institute for Microbial Diseases, Osaka University
    Nippon Rinsho 59:1605-13. 2001
    b>Borna disease virus(BDV) is a noncytolytic, neurotropic RNA virus that causes a disease of the central nervous system(CNS) in several vertebrate species, including horses, sheep, cats and ostriches...
  19. pmc Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:50. 2008
    Neonatal Borna disease virus (BDV) infection of the rat brain is associated with microglial activation and damage to certain neuronal populations...
  20. pmc Borna disease virus infection in animals and humans
    J A Richt
    Institut fur Virologie, Giessen, Germany
    Emerg Infect Dis 3:343-52. 1997
    The geographic distribution and host range of Borna disease (BD), a fatal neurologic disease of horses and sheep, are larger than previously thought...
  21. ncbi Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism
    M V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Behav Brain Res 100:43-50. 1999
    ..were observed in male juvenile Lewis rats with brain developmental injury following neonatal infection with Borna disease virus (BDV)...
  22. ncbi Detection of Borna disease virus in a pregnant mare and her fetus
    K Hagiwara
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
    Vet Microbiol 72:207-16. 2000
    ..mare showing pyrexia, reduced appetite, ataxia and paresis was euthanized and examined for the presence of Borna disease virus (BDV)...
  23. ncbi Detection of antibodies to Borna disease virus (BDV) in Turkish horse sera using recombinant p40. Brief report
    H Yilmaz
    University of Istanbul, Veterinary Faculty, Department of Microbiology, Avcilar, Turkey
    Arch Virol 147:429-35. 2002
    The nucleoprotein of Borna disease virus (BDV-p40) was produced in a Baculovirus expression system using sf9 cells. The purity and specificity of the recombinant p40 was confirmed by SDS-PAGE and immunoblotting...
  24. ncbi Seroprevalence of Borna disease virus in domestic animals in Xinjiang, China
    K Hagiwara
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyoudai Midorimachi Ebetsu, 069 8501, Hokkaido, Japan
    Vet Microbiol 80:383-9. 2001
    To investigate the animals infected with Borna disease virus (BDV) in Xinjiang, China, we examined for BDV antibodies in the sera from groups of 20 horses, sheep and cattle, and from 165 wild rodents (18 species) by ELISA and immunoblot...
  25. ncbi Borna disease virus and mental health: a cross-sectional study
    D Rh Thomas
    NPHS Communicable Disease Surveillance Centre, Abton House, Wedal Road, Cardiff CF14 3QX, UK
    QJM 98:247-54. 2005
    b>Borna disease is an infectious neurological disease of horses, sheep and possibly other animals...
  26. ncbi Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration
    Michael Bacher
    Institute of Immunology, Philipps University, Marburg, Germany
    Glia 37:291-306. 2002
    ..invasion during virus-induced encephalitis, we analyzed the expression and cellular localization of MIF in the Borna disease virus (BDV)-infected rat brain, monitored monocyte/macrophage infiltration, and evaluated the influence of ..
  27. ncbi Experimental infection of mice with Borna disease virus (BDV): replication and distribution of the virus after intracerebral infection
    H K Enbergs
    Institute of Virology, Faculty of Veterinary Medicine, Leipzig, Germany
    J Neurovirol 7:272-7. 2001
    To develop an animal model resembling natural asymptomatic Borna disease virus (BDV) infections, BDV He/80 rat brain homogenate was passaged four times in adult SJL/J mice...
  28. pmc Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats
    Marion Poenisch
    Department of Virology, University of Freiburg, Freiburg, Germany
    J Virol 83:4297-307. 2009
    b>Borna disease virus (BDV) is a neurotropic member of the order Mononegavirales with noncytolytic replication and obligatory persistence in cultured cells and animals...
  29. ncbi Demonstration of continuously seropositive population against Borna disease virus in Misaki feral horses, a Japanese strain: a four-year follow-up study from 1998 to 2001
    Yoichi Inoue
    Department of Veterinary Teaching Hospital and Internal Medicine, Faculty of Agriculture, Miyazaki University, Gakuen KibanaDai, Japan
    J Vet Med Sci 64:445-8. 2002
    b>Borna disease virus (BDV)-specific antibodies were monitored in Misaki feral horses annually for 4 years using an electrochemiluminescence immunoassay (ECLIA). Among 130 horses examined, 35 (26...
  30. doi Anti-Borna disease virus antibody responses in psychiatric patients: long-term follow up
    Alexander Heinrich
    Department of Neurology and Clinical Neurophysiology, Henriettenstiftung Hannover, Hannover, Germany
    Psychiatry Clin Neurosci 64:255-61. 2010
    Data suggesting a pathogenetic role for Borna disease virus (BDV) in neuropsychiatric diseases are still inconclusive and it is unknown whether humans become persistently infected or clear the virus infection...
  31. pmc Borna disease in a free-ranging lynx (Lynx lynx)
    M P Degiorgis
    Department of Wildlife, National Veterinary Institute, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Clin Microbiol 38:3087-91. 2000
    ..In situ hybridization, immunohistochemistry, and reverse transcriptase PCR analysis showed the presence of Borna disease virus infection in the brain...
  32. pmc Visualizing viral dissemination in the mouse nervous system, using a green fluorescent protein-expressing Borna disease virus vector
    Andreas Ackermann
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 84:5438-42. 2010
    b>Borna disease virus (BDV) frequently persists in the brain of infected animals. To analyze viral dissemination in the mouse nervous system, we generated a mouse-adapted virus that expresses green fluorescent protein (GFP)...
  33. ncbi Borna disease virus: a mystery as an emerging zoonotic pathogen
    J A Richt
    Institut fur Virologie, Frankfurterstrasse 107, D 35392 Giessen, Germany
    Vet J 161:24-40. 2001
    For Central European veterinarians, Borna disease (BD) has been known for a long time as a sporadically occurring, progressive viral polioencephalomyelitis predominantly affecting horses and sheep and-as discovered in the last decade-an ..
  34. ncbi Distribution of Borna disease virus antigen and RNA in tissues of naturally infected bicolored white-toothed shrews, Crocidura leucodon, supporting their role as reservoir host species
    M E Puorger
    University of Zurich, Zurich, Switzerland
    Vet Pathol 47:236-44. 2010
    b>Borna disease is a severe viral-induced disorder of the central nervous system of horses, sheep, and a few other animal species, occurring in certain areas of central Europe...
  35. pmc Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1
    Gunhild Unterstab
    Robert Koch Institute, FG12, Nordufer 20, 13353 Berlin, Germany
    Proc Natl Acad Sci U S A 102:13640-5. 2005
    ..b>Borna disease virus (BDV) establishes persistent noncytolytic infections in animals and tissue culture cells, indicating ..
  36. pmc Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus
    B L Williams
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Virol 80:8613-26. 2006
    b>Borna disease virus infection of neonatal rats results in a characteristic behavioral syndrome and apoptosis of subsets of neurons in the hippocampus and cerebellum (neonatal Borna disease [NBD])...
  37. pmc Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection
    Brent L Williams
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, 722 West 168th Street, Rm 1801, New York, NY 10032, USA
    J Virol 81:2675-87. 2007
    Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life...
  38. pmc Borna disease virus infection impairs synaptic plasticity
    Romain Volmer
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, 31024 Toulouse Cedex 3, France
    J Virol 81:8833-7. 2007
    The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood...
  39. pmc High-dose Borna disease virus infection induces a nucleoprotein-specific cytotoxic T-lymphocyte response and prevention of immunopathology
    E Furrer
    , , , Germany
    J Virol 75:11700-8. 2001
    Experimental Borna disease virus (BDV) infection of rats and natural infection of horses and sheep leads to severe central nervous system disease based on immunopathological pathways...
  40. ncbi No evidence of endemic Borna disease virus infection in Australian horses in contrast with endemic infection in other continents
    S Kamhieh
    Northern Blood Research Centre, St Leonards, NSW, Australia
    Arch Virol 151:709-19. 2006
    b>Borna disease virus (BDV) is a unique RNA virus that is a cause of neurological disease in horses, sheep and cats. The finding that BDV also infects humans has raised concern related to the impact of infection with this virus...
  41. ncbi Borna disease virus interference with neuronal plasticity
    Daniel Gonzalez-Dunia
    Avenir Group, INSERM U563, CPTP Bat B, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Virus Res 111:224-34. 2005
    ..The mechanisms whereby such infections disturb brain functions are beginning to emerge. Borna disease virus (BDV), which causes a persistent infection of neurons without direct cytolysis in several mammalian ..
  42. ncbi Neurological diseases and viral dynamics in the brains of neonatally borna disease virus-infected gerbils
    M Watanabe
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Virology 282:65-76. 2001
    b>Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that causes a chronic neurological disease in a wide variety of animal species...
  43. pmc Isolation and characterization of a new subtype of Borna disease virus
    N Nowotny
    Institute of Virology, University of Veterinary Sciences, Vienna, A 1210 Vienna, Austria
    J Virol 74:5655-8. 2000
    b>Borna disease virus (BDV), the causative agent of severe meningoencephalitis in a wide variety of animal species, has been considered to be genetically invariable and to form a single type within the genus Bornavirus of the family ..
  44. ncbi Meta-analysis of putative human bornavirus sequences fails to provide evidence implicating Borna disease virus in mental illness
    Ralf Durrwald
    Impfstoffwerk Dessau Tornau GmbH IDT, Rodleben, Germany
    Rev Med Virol 17:181-203. 2007
    All Borna disease virus (BDV) sequences derived from human specimens published till date were thoroughly analysed and compared to sequences of BDV laboratory strains and to BDV sequences from animals which succumbed to classical Borna ..
  45. ncbi The immunopathogenesis of Borna disease virus infection
    Lothar Stitz
    Institute for Immunology, Federal Research Center for Virus Diseases of Animals, Paul Ehrlich Strasse 28, D 72076 Tubingen, FRG
    Front Biosci 7:d541-55. 2002
    b>Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system...
  46. ncbi Borna disease virus and the evidence for human pathogenicity: a systematic review
    R M Chalmers
    NPHS Communicable Disease Surveillance Centre, Abton House, Wedal Road, Cardiff CF14 3QX, UK
    QJM 98:255-74. 2005
    b>Borna disease is a neurological viral disease of veterinary importance in central Europe, although Borna Disease virus (BDV) has been reported to be present in animals in most continents...
  47. ncbi Borna disease virus and psychiatry
    O Taieb
    Department of Virology, CERVI, , 75013 Paris, France
    Eur Psychiatry 16:3-10. 2001
    b>Borna disease virus (BDV), a noncytolytic neurotropic nonsegmented negative-stranded RNA virus with a wide geographic distribution, infects several vertebrate animal species and causes an immune-mediated central nervous system (CNS) ..
  48. ncbi Molecular biology of Borna disease virus and persistence
    Juan Carlos de la Torre
    Department of Neuropharmacology, Division of Virology, IMM 6, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Front Biosci 7:d569-79. 2002
    b>Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities...
  49. ncbi Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility
    Yohei Watanabe
    Department of Virology, Research Institute for Microbial Diseases BIKEN, Osaka University, Suita, Osaka 565 0871, Japan
    Microbes Infect 9:417-27. 2007
    To investigate the biological characteristics of field isolates of Borna disease virus (BDV), as well as to understand BDV infections outside endemic countries, we isolated the virus from brain samples of a heifer with Borna disease in ..
  50. ncbi Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficits
    Mikhail V Pletnikov
    Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 944:97-107. 2002
    ..In the two consecutive papers, we used the neonatal Borna disease virus (BDV) infection rat model of neurodevelopmental damage to evaluate brain pathology, monoamine ..
  51. ncbi Molecular and cellular biology of Borna disease virus infection
    Keizo Tomonaga
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Microbes Infect 4:491-500. 2002
    b>Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that causes neurobehavioral disorders in a wide variety of warm-blooded animals...
  52. pmc Persistence of Borna disease virus in naturally infected sheep
    Thomas W Vahlenkamp
    Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany
    J Virol 76:9735-43. 2002
    To get an insight into Borna disease virus (BDV) epidemiology, an isolated flock of approximately 25 sheep within the region of Southeast Germany to which the disease is endemic was investigated over a 3-year observation period...
  53. ncbi Humoral immune response against Borna disease virus (BDV) in experimentally and naturally infected cats
    M Johansson
    Department of Pathology, Swedish University of Agricultural Sciences SUAS, 750 07, Uppsala, Sweden
    Vet Immunol Immunopathol 90:23-33. 2002
    In order to investigate the peripheral and intracerebral humoral immune response against Borna disease virus (BDV) in cats, serum and cerebrospinal fluid (CSF) samples from experimentally and naturally BDV-infected cats were analysed in ..
  54. pmc Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components
    Till Geib
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Virol 77:4283-90. 2003
    ..We present evidence for superinfection exclusion in brains of Borna disease virus (BDV)-infected rats and in persistently infected Vero cells, and we suggest that acquired resistance to ..
  55. ncbi Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland
    Paula M Kinnunen
    Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, P O Box 66, 00014 University of Helsinki, Finland
    J Clin Virol 38:64-9. 2007
    b>Borna disease virus (BDV) can infect many vertebrate species, including humans. BDV infection may lead to meningoencephalomyelitis in animals...
  56. ncbi Sero-epidemiological study of Borna disease virus infection in the Italian equine population
    G Pisoni
    Department of Veterinary Pathology, Hygiene and Public Health, Institute of Infectious Diseases, University of Milan, Milan, Italy
    Vet Res Commun 31:245-8. 2007
  57. ncbi Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brain
    Mikhail V Pletnikov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cerebellum 2:62-70. 2003
    ..One of the most interesting in vivo models of virus-induced cerebellar damage is the neonatal Borna disease virus (BDV) infection of the rat brain...
  58. pmc Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice
    Wataru Kamitani
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 100:8969-74. 2003
    ..Here, we show that transgenic mice expressing the phosphoprotein (P) of Borna disease virus (BDV) in glial cells develop behavioral abnormalities, such as enhanced intermale aggressiveness, ..
  59. ncbi Infection of the enteric nervous system by Borna disease virus (BDV) upregulates expression of Calbindin D-28k
    Helga Pfannkuche
    Institute of Veterinary Physiology, Faculty of Veterinary Medicine, An den Tierkliniken 7, Leipzig University, 04103 Leipzig, Germany
    Vet Microbiol 127:275-85. 2008
    b>Borna disease virus (BDV) is a neurotropic agent infecting distinct neuronal subpopulations in the central nervous system of various mammalian species possibly including humans...
  60. doi Viral accessory protein X stimulates the assembly of functional Borna disease virus polymerase complexes
    Marion Poenisch
    Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
    J Gen Virol 89:1442-5. 2008
    The Borna disease virus (BDV) proteins X and P are translated from a bicistronic viral mRNA...
  61. pmc Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:16. 2008
    Neonatal Borna Disease Virus (BDV) infection in rats leads to a neuronal loss in the cortex, hippocampus and cerebellum...
  62. ncbi Borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the Czech Republic
    Sylva Rackova
    Department of Psychiatry, University Hospital, Medical Faculty, Charles University in Pilsen, Alej Svobody 80, Pilsen, Czech Republic
    Neuro Endocrinol Lett 30:414-20. 2009
    b>Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. BDV is a neurotropic virus that causes changes in mood, behaviour and cognition...
  63. pmc Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules
    Roberto Clemente
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 83:10406-16. 2009
    b>Borna disease virus (BDV), the prototypic member of the Bornaviridae family within the order Mononegavirales, exhibits high neurotropism and provides an important and unique experimental model system for studying virus-cell interactions ..
  64. ncbi Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis
    David Dietz
    Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland 21205, USA
    J Neurovirol 10:267-77. 2004
    Neonatal Borna disease virus (BDV) infection of the rat brain serves as a valuable model for studying the pathogenesis of neurodevelopmental abnormalities following early brain injury...
  65. ncbi Susceptibility of Borna disease virus to the antiviral action of gamma-interferon: evidence for species-specific differences
    C Sauder
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Medical School, Freiburg, Germany
    Arch Virol 149:2171-86. 2004
    b>Borna disease virus (BDV) infection in its predominant natural host - horses and sheep - leads to fatal meningoencephalomyelitis...
  66. pmc Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication
    Soizic Bourteele
    Institut fur Immunologie, Friedrich Loeffler Institut, Bundesforschungsinstitut für Tiergesundheit, Paul Ehrlich Str 28, 72076 Tubingen, Germany
    J Virol 79:6043-51. 2005
    ..b>Borna disease virus (BDV) is a neurotropic negative-strand RNA virus, which replicates in the nucleus of the infected cell ..
  67. doi RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives
    Sandra Odebrechet Vargas Nunes
    Department of Psychiatry, State University of Londrina, Londrina, PR, Brazil
    J Clin Lab Anal 22:314-20. 2008
    ..Detection of p24 RNA from Borna disease virus (BDV) by the reverse transcriptase polymerase chain reaction in patients with schizophrenia, ..
  68. ncbi Reverse transcription real-time PCR assays for detection and quantification of Borna disease virus in diseased hosts
    A R Schindler
    Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 266a, CH 8057 Zurich, Switzerland
    Mol Cell Probes 21:47-55. 2007
    b>Borna disease is a severe, immunopathological disorder of the central nervous system caused by the infection with the Borna disease virus (BDV)...
  69. pmc Shrews as reservoir hosts of borna disease virus
    Monika Hilbe
    University of Zurich, Zurich, Switzerland
    Emerg Infect Dis 12:675-7. 2006
    b>Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other animal species in central Europe...
  70. ncbi Bornavirus and the brain
    Juan Carlos de la Torre
    Department of Neuropharmacology, Division of Virology, IMM 6, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Infect Dis 186:S241-7. 2002
    b>Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities. BDV is a nonsegmented, negative, single-stranded RNA virus...
  71. pmc A functional role for neutralizing antibodies in Borna disease: influence on virus tropism outside the central nervous system
    L Stitz
    Institut für Impfstoffe, Bundesforschungsanstalt fur Viruskrankheiten der Tiere, Tubingen, Germany
    J Virol 72:8884-92. 1998
    b>Borna disease virus (BDV) is a negative-strand RNA virus that infects the central nervous systems (CNS) of warm-blooded animals and causes disturbances of movement and behavior...
  72. pmc The nucleolus is the site of Borna disease virus RNA transcription and replication
    J M Pyper
    Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 72:7697-702. 1998
    b>Borna disease virus (BDV) is a neurotropic nonsegmented negative-strand RNA virus with limited homology to rhabdoviruses and paramyxoviruses. A distinguishing feature of BDV is that it replicates in the nucleus of infected cells...
  73. ncbi Borna disease virus--does it infect humans and cause psychiatric disorders?
    K Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Clin Virol 21:119-27. 2001
    Antibodies recognizing Borna disease virus (BDV) antigens were first demonstrated in the blood of psychiatric patients approximately 15 years ago...
  74. ncbi Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease
    M Hornig
    Laboratory for the Study of Emerging Diseases, 3101 Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697-4292, USA
    Curr Top Microbiol Immunol 253:157-77. 2001
    ..Two models have been established based on Borna disease virus infection that provide new insights into mechanisms by which neurotropic agents and/or immune factors ..
  75. ncbi Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies--the key marker triplet determining infection and prevailing in severe mood disorders
    L Bode
    Project Bornavirus Infections, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Mol Psychiatry 6:481-91. 2001
    b>Borna disease virus (BDV), a unique genetically highly conserved RNA virus (Bornaviridae; Mononegavirales), preferentially targets neurons of limbic structures causing behavioral abnormalities in animals...
  76. ncbi Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Neurovirol 8:168-79. 2002
    Infection of adult rats with Borna disease virus (BDV) causes CD8 T cell-mediated meningoencephalitis. Previously, we described a complex pattern of chemokine gene expression in the central nervous system (CNS) of such rats...
  77. ncbi Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders
    Mikhail V Pletnikov
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Front Biosci 7:d593-607. 2002
    ..The present review provides a detailed analysis of a new animal model of ASD. This model utilizes neonatal Borna disease virus (BDV) infection of the rat brain as a unique experimental teratogen to study the pathogenesis of ..
  78. ncbi Electrophysiological alterations and upregulation of ATP receptors in retinal glial Müller cells from rats infected with the Borna disease virus
    T Pannicke
    Paul Flechsig Institut für Hirnforschung, Universitat Leipzig, Leipzig, Germany
    Glia 35:213-23. 2001
    Infection with the neurotropic Borna disease virus (BDV) causes an immune-mediated neurological disease in a broad range of species...
  79. ncbi Conservation of coding potential and terminal sequences in four different isolates of Borna disease virus
    S Pleschka
    Institute of Virology, University of Giessen, D-35392 Giessen, Germany
    J Gen Virol 82:2681-90. 2001
    We determined the complete nucleotide sequences of two poorly characterized strains of Borna disease virus (BDV) and compared them to reference strains V and He/80...
  80. pmc Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation
    C Sauder
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79104 Freiburg
    J Virol 74:9267-80. 2000
    b>Borna disease virus (BDV) causes CD8(+) T-cell-mediated meningoencephalitis in immunocompetent mice and rats, thus providing a valuable animal model for studying the mechanisms of virus-induced central nervous system (CNS) ..
  81. ncbi High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins
    Christian Billich
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Biol Psychiatry 51:979-87. 2002
    The recent observation that Borna disease virus (BDV)-reactive antibodies from psychiatric patients exhibit only low avidity for BDV antigen called into question their diagnostic value and raised the possibility that antigenically ..
  82. ncbi Persistent Borna disease virus infection of neonatal rats causes brain regional changes of mRNAs for cytokines, cytokine receptor components and neuropeptides
    C R Plata-Salaman
    Division of Molecular Biology, School of Life and Health Sciences, University of Delaware, Newark, USA
    Brain Res Bull 49:441-51. 1999
    b>Borna disease virus (BDV) replicates in brain cells. The neonatally infected rat with BDV exhibits developmental-neuromorphological abnormalities, neuronal cytolysis, and multiple behavioral and physiological alterations...
  83. ncbi Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems
    M V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res Dev Brain Res 119:179-85. 2000
    Effects of neonatal Borna disease virus infection (BDV) on the postnatal development of brain monoaminergic systems in rats were studied...
  84. pmc Synaptic pathology in Borna disease virus persistent infection
    D Gonzalez-Dunia
    Unite des Virus Lents, CNRS URA 1930, Institut Pasteur, Paris, France
    J Virol 74:3441-8. 2000
    b>Borna disease virus (BDV) infection of newborn rats leads to a persistent infection of the brain, which is associated with behavioral and neuroanatonomical abnormalities...
  85. pmc Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation
    K M Carbone
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Virol 61:3431-40. 1987
    b>Borna disease virus is an uncharacterized agent that causes sporadic but fatal neurological disease in horses and sheep in Europe...
  86. pmc Adaptation of Borna disease virus to new host species attributed to altered regulation of viral polymerase activity
    Andreas Ackermann
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 81:7933-40. 2007
    b>Borna disease virus (BDV) can persistently infect the central nervous system of a broad range of mammalian species...
  87. pmc Virus-specific CD4+ T cells eliminate borna disease virus from the brain via induction of cytotoxic CD8+ T cells
    K Nöske
    Institut fur Virologie, Justus Liebig Universitat Giessen, Tubingen, Germany
    J Virol 72:4387-95. 1998
    Persistent Borna disease virus infection of the brain can be prevented by treatment of naive rats with a virus-specific CD4+ T-cell line prior to infection...
  88. ncbi Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients
    Helen Cristina Miranda
    Department of Pathological Sciences Immunology, Londrina State University, Londrina, PR, Brazil
    J Affect Disord 90:43-7. 2006
    b>Borna disease virus (BDV) is a virus that naturally infects a broad range of warm-blooded animals...
  89. ncbi Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats
    Marylou V Solbrig
    Department of Neurology, University of California Irivne, Irvine, California 92697 4292, USA
    J Neurovirol 14:252-60. 2008
    ..b>Borna disease virus (BDV) in rats causes cortical and subcortical infection with extrapyramidal motor symptoms, and ..
  90. doi Layer specific changes of astroglial gap junctions in the rat cerebellar cortex by persistent Borna Disease Virus infection
    Christiane Köster-Patzlaff
    Center for Anatomy, Neuroanatomy, University of Gottingen, Kreuzbergring 36, 37075 Gottingen, Germany
    Brain Res 1219:143-58. 2008
    Neonatal Borna Disease Virus (BDV) infection of the Lewis rat brain, leads to Purkinje cell degeneration, in association with astroglial activation...
  91. ncbi Metallothioneins and zinc dysregulation contribute to neurodevelopmental damage in a model of perinatal viral infection
    Brent L Williams
    Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Brain Pathol 16:1-14. 2006
    Neonatal Borna disease (NBD) virus infection in the Lewis rat results in life-long viral persistence and causes behavioral and neurodevelopmental abnormalities...
  92. pmc Alpha/beta interferon promotes transcription and inhibits replication of borna disease virus in persistently infected cells
    P Staeheli
    Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 75:8216-23. 2001
    b>Borna disease virus (BDV) is a noncytolytic RNA virus that can replicate in the central nervous system (CNS) of mice...
  93. doi Implications for a regulated replication of Borna disease virus in brains of experimentally infected Lewis rats
    Doris Porombka
    Department of Pathology, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Virus Genes 36:415-20. 2008
    The neurotropic Borna disease virus (BDV) causes typically a persistent virus infection of the central nervous system...
  94. ncbi Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus
    Karen Lancaster
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Behav Brain Res 176:141-8. 2007
    ..In this report, we briefly review our animal model of ASD based on neonatal Borna disease virus (BDV) infection and present new data about abnormal social interaction in adult BDV-infected rats...
  95. pmc Neutralizing antibodies in persistent borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitis
    E Furrer
    , , , Germany
    J Virol 75:943-51. 2001
    b>Borna disease virus (BDV) infection triggers an immune-mediated encephalomyelitis and results in a persistent infection...
  96. ncbi PrPSc level and incubation time in a transgenic mouse model expressing Borna disease virus phosphoprotein after intracerebral prion infection
    Akikazu Sakudo
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 431:81-5. 2008
    Our previous studies have shown that the persistent expression of Borna disease virus phosphoprotein (BDV P) in mice leads to behavioral abnormalities resembling those in BDV-infected animals...
  97. pmc Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan
    K Fukuda
    Department of Microbiology, Fukushima Medical University, Fukushima-shi, Fukushima 960-1295, Japan
    J Clin Microbiol 39:419-29. 2001
    The involvement of Borna disease virus (BDV) in psychiatric diseases in humans remains controversial...
  98. ncbi Borna disease virus
    I Jordan
    Emerging Diseases Laboratory, Department of Neurology, University of California-- Irvine, Irvine, California 92697-4292, USA
    Rev Med Virol 11:37-57. 2001
    b>Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species...
  99. pmc Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus
    Naohiro Ohtaki
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Virol 81:5940-8. 2007
    b>Borna disease virus (BDV) is a neurotropic virus that causes a persistent infection in the central nervous system (CNS) of many vertebrate species...
  100. ncbi Prevalence of circulating antibodies to p10, a non-structural protein of the Borna disease virus in cats with ataxia
    A Ouchi
    Tsukuba Central Laboratories, Kyoritsu Seiyaku Corporation, Inashiki-gun, Ibaraki, Japan
    J Vet Med Sci 63:1279-85. 2001
    Japanese domestic cats were surveyed for circulating antibodies to the plO and p24 proteins of the Borna disease virus (BDV) by Western blotting. Twenty-four of 52 cats (46...
  101. pmc Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells
    Daniel Mayer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 79:11716-23. 2005
    In the hippocampus of Borna disease virus (BDV)-infected newborn rats, dentate granule cells undergo progressive cell death...

Research Grants88

  1. PERSISTENCE OF DISEASE VIRUS IN ASTROCYTES
    Kathryn Carbone; Fiscal Year: 1990
    b>Borna disease virus (BDV) replicates only in the nervous system and produces a persistent, productive infection...
  2. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 1999
    DESCRIPTION (Applicant's Abstract): Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warm blooded animals to cause disturbances of movement and behavior...
  3. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2000
    DESCRIPTION (Applicant's Abstract): Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warm blooded animals to cause disturbances of movement and behavior...
  4. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
    DESCRIPTION (Applicant's Abstract): Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warm blooded animals to cause disturbances of movement and behavior...
  5. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2001
    DESCRIPTION (Applicant's Abstract): Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warm blooded animals to cause disturbances of movement and behavior...
  6. BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENT
    Kathryn Carbone; Fiscal Year: 1991
    ..scientists and neuroanatomists propose to study a model of encephalitis virus infection in the neonate, Borna disease virus (BDV)...
  7. BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENT
    Kathryn Carbone; Fiscal Year: 1992
    ..scientists and neuroanatomists propose to study a model of encephalitis virus infection in the neonate, Borna disease virus (BDV)...
  8. NONHUMAN PRIMATE MODEL OF PERSISTENT BORNA DISEASE VIRUS INFECTION
    Nicholas Lerche; Fiscal Year: 1999
    Significance Borna disease virus (BDV) infects a broad range of warmblooded species (mammals and birds) to cause neurologic dysfunction...
  9. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 1999
    ..of all proteins of paramyxo-, rhabdo- and filoviruses, (with privileged access to new Ebola sequences), and Borna Disease virus, (including potential BDV sequences from schizophrenic patients); and 3) the analysis of the dUTPase ..
  10. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 1999
    ..of all proteins of paramyxo-, rhabdo- and filoviruses, (with privileged access to new Ebola sequences), and Borna Disease virus, (including potential BDV sequences from schizophrenic patients); and 3) the analysis of the dUTPase ..
  11. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 2000
    ..of all proteins of paramyxo-, rhabdo- and filoviruses, (with privileged access to new Ebola sequences), and Borna Disease virus, (including potential BDV sequences from schizophrenic patients); and 3) the analysis of the dUTPase ..
  12. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 1999
    ..of all proteins of paramyxo-, rhabdo- and filoviruses, (with privileged access to new Ebola sequences), and Borna Disease virus, (including potential BDV sequences from schizophrenic patients); and 3) the analysis of the dUTPase ..
  13. BORNA VIRUS--AN EMERGING NEUROTROPIC PATHOGEN IN HUMANS
    JUAN DE LA TORRE; Fiscal Year: 1999
    ..b>Borna disease virus (BDV) causes central nervous system (CNS) disease in several vertebrate species which is characterized ..
  14. BORNA VIRUS--AN EMERGING NEUROTROPIC PATHOGEN IN HUMANS
    JUAN DE LA TORRE; Fiscal Year: 2000
    ..b>Borna disease virus (BDV) causes central nervous system (CNS) disease in several vertebrate species which is characterized ..
  15. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 1999
    ..and either affective disorders or schizophrenia, a potential role in their pathogenesis has been suggested for Borna disease virus (BDV)...
  16. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2000
    ..and either affective disorders or schizophrenia, a potential role in their pathogenesis has been suggested for Borna disease virus (BDV)...
  17. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 2000
    ..An animal model of a persistent CNS viral infection based on experimental Borna disease virus infection of the rat will be developed then tested for 1) the reinforcing effects of opiates as measured ..
  18. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 2001
    ..An animal model of a persistent CNS viral infection based on experimental Borna disease virus infection of the rat will be developed then tested for 1) the reinforcing effects of opiates as measured ..
  19. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 1999
    ..An animal model of a persistent CNS viral infection based on experimental Borna disease virus infection of the rat will be developed then tested for 1) the reinforcing effects of opiates as measured ..
  20. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2001
    ..This project will explore an animal model of autism based on CNS infection in early life. Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warmblooded animals to cause disturbances ..
  21. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2000
    ..This project will explore an animal model of autism based on CNS infection in early life. Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warmblooded animals to cause disturbances ..
  22. MOLECULAR ANALYIS OF A NEUROTROPIC AGENT, BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1993
    b>Borna disease (BD) is an infectious neurologic disease characterized by profound behavioral disturbances and the accumulation of specific antigens in limbic system neurons...
  23. MOLECULAR ANALYIS OF A NEUROTROPIC AGENT, BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1992
    b>Borna disease (BD) is an infectious neurologic disease characterized by profound behavioral disturbances and the accumulation of specific antigens in limbic system neurons...
  24. MOLECULAR ANALYIS OF A NEUROTROPIC AGENT, BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1991
    b>Borna disease (BD) is an infectious neurologic disease characterized by profound behavioral disturbances and the accumulation of specific antigens in limbic system neurons...
  25. Identification of Borna Disease Virus Receptor Proteins
    JUAN DE LA TORRE; Fiscal Year: 2005
    b>Borna disease virus (BDV) is an enveloped virus with a non-segmented negative strand (NNS) RNA genome. Because of its unique features BDV is the prototypic member of a new virus family...
  26. BORNA DISEASE VIRUS--CLONING OF ORF-5 CDNAS
    Patrick Lai; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Applicant's Abstract): The Borna disease virus (BDV) is an enveloped, negative, non-segmented, single stranded (NNS), RNA virus...
  27. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 1999
    b>Borna disease virus (BDV) provides an important model for the study of both the mechanisms and consequences of viral persistence in the central nervous system (CNS), a subject with important health implications given the evidence that ..
  28. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 1999
    b>Borna disease virus (BDV) provides an important model for the study of both the mechanisms and consequences of viral persistence in the central nervous system (CNS), a subject with important health implications given the evidence that ..
  29. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2002
    b>Borna disease virus (BDV) provides an important model for the study of viral persistence4n the central nervous system (CNS), a subject relevant to health given the evidence that viruses can contribute to slowly progressive human ..
  30. BORNA DISEASE USING NUCLEIC ACID PROBES
    Bernhard Dietzschold; Fiscal Year: 1990
    ..Since Borna disease (BD) virus has a specific affinity for those brain areas thought to be involved with depression (e.g...
  31. BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENT
    Timothy Moran; Fiscal Year: 2000
    ..Studies of Borna disease virus (BDV)-infected neonatal Lewis rats have revealed important principles about the neuroanatomical and ..
  32. BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENT
    Timothy Moran; Fiscal Year: 2002
    ..Studies of Borna disease virus (BDV)-infected neonatal Lewis rats have revealed important principles about the neuroanatomical and ..
  33. BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENT
    Timothy Moran; Fiscal Year: 1999
    ..Studies of Borna disease virus (BDV)-infected neonatal Lewis rats have revealed important principles about the neuroanatomical and ..
  34. BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENT
    Timothy Moran; Fiscal Year: 2001
    ..Studies of Borna disease virus (BDV)-infected neonatal Lewis rats have revealed important principles about the neuroanatomical and ..
  35. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2002
    ..This project will explore an animal model of autism based on CNS infection in early life. Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warmblooded animals to cause disturbances ..
  36. IRC--CLASSIFICATION AND COURSE OF SCHIZOPHRENIAS
    William Carpenter; Fiscal Year: 2002
    ..and etiologically relevant data on season of birth, pathology in biological relatives, and seropositivity for borna disease virus...
  37. IRC--CLASSIFICATION AND COURSE OF SCHIZOPHRENIAS
    William Carpenter; Fiscal Year: 2000
    ..and etiologically relevant data on season of birth, pathology in biological relatives, and seropositivity for borna disease virus...
  38. IRC--CLASSIFICATION AND COURSE OF SCHIZOPHRENIAS
    William Carpenter; Fiscal Year: 2001
    ..and etiologically relevant data on season of birth, pathology in biological relatives, and seropositivity for borna disease virus...
  39. VIRUSES NEUROTRANSMITTERS AND NEUROLOGICAL DISEASES
    WALTER LIPKIN; Fiscal Year: 1990
    ..During the last two years of this project, I will focus on Borna disease virus (BDV), an intriguing infectious agent with wide host range and tropism for selected CNS regions...
  40. IRC--CLASSIFICATION AND COURSE OF SCHIZOPHRENIAS
    William Carpenter; Fiscal Year: 1999
    ..and etiologically relevant data on season of birth, pathology in biological relatives, and seropositivity for borna disease virus...
  41. NEUROIMMUNOLOGY/VIROLOGY OF SCHIZOPHRENIA
    Royce Waltrip; Fiscal Year: 1990
    ..The applicant will participate in ongoing studies of the immunological response to Borna disease virus (BDV) infection in Lewis rats in the laboratory as an intensive basic science and laboratory training ..
  42. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1999
    This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular ..
  43. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2001
    This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular ..
  44. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2000
    This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular ..
  45. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1999
    This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular ..
  46. Viral neuropathology neuropeptides and epilepsy
    Marylou Solbrig; Fiscal Year: 2003
    ..The generality of the hypothesis, the mechanism of effect, and treatments will be studied. Borna Disease virus, a neurotropic virus causing hippocampal degeneration in many mamma an species, is a rare cause of ..
  47. Viral neuropathology neuropeptides and epilepsy
    Marylou Solbrig; Fiscal Year: 2005
    ..The generality of the hypothesis, the mechanism of effect, and treatments will be studied. Borna Disease virus, a neurotropic virus causing hippocampal degeneration in many mamma an species, is a rare cause of ..
  48. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 2002
    ..An animal model of a persistent CNS viral infection based on experimental Borna disease virus infection of the rat will be developed then tested for 1) the reinforcing effects of opiates as measured ..
  49. Viral neuropathology neuropeptides and epilepsy
    Marylou Solbrig; Fiscal Year: 2004
    ..The generality of the hypothesis, the mechanism of effect, and treatments will be studied. Borna Disease virus, a neurotropic virus causing hippocampal degeneration in many mamma an species, is a rare cause of ..
  50. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2003
    ..This project will explore an animal model of autism based on CNS infection in early life. Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warmblooded animals to cause disturbances ..
  51. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2000
    This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular ..
  52. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2000
    b>Borna disease virus (BDV) provides an important model for the study of both the mechanisms and consequences of viral persistence in the central nervous system (CNS), a subject with important health implications given the evidence that ..
  53. Targeting the processing of the arenavirus glycoprotein for anti-viral therapy.
    JUAN DE LA TORRE; Fiscal Year: 2009
    ....
  54. Immune cell dynamics during central nervous system viral infection
    Juan C de la Torre; Fiscal Year: 2010
    ..abstract_text> ..
  55. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2003
    b>Borna disease virus (BDV) provides an important model for the study of viral persistence4n the central nervous system (CNS), a subject relevant to health given the evidence that viruses can contribute to slowly progressive human ..
  56. Anti-interferon Activity of the Arenavirus Nucleoprotein
    Luis Martinez Sobrido; Fiscal Year: 2010
    ..This knowledge should fuel the development of better antiviral strategies to combat human pathogenic arenaviruses. ..
  57. Viral Pathogenesis of Neural and Behavior Injury
    Mikhail Pletnikov; Fiscal Year: 2005
    ..continuation application, we propose to use our small animal model of viral neuropathogenesis, neonatal Borna disease virus infection (BDV), to study the mechanisms by which soluble neurotoxins (e.g...
  58. Inducible expression of mutant DISC1: transgenic mouse model
    Mikhail Pletnikov; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  59. Viral Arrays for Biodefense
    W Ian Lipkin; Fiscal Year: 2007
    ....
  60. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    WALTER LIPKIN; Fiscal Year: 2006
    ....
  61. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  62. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2003
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  63. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2002
    ..This will provide a new and powerful approach to the study of the arenavirus molecular biology and pathogenesis. ..