borna disease

Summary

Summary: An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.

Top Publications

  1. ncbi Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland
    Paula M Kinnunen
    Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, P O Box 66, 00014 University of Helsinki, Finland
    J Clin Virol 38:64-9. 2007
  2. pmc Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells
    Rongzhong Huang
    Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    PLoS ONE 7:e44665. 2012
  3. ncbi Experimental vertical transmission of Borna disease virus in the mouse
    M Okamoto
    Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Arch Virol 148:1557-68. 2003
  4. ncbi Epidemiology and host spectrum of Borna disease virus infections
    Paula M Kinnunen
    Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Finland
    J Gen Virol 94:247-62. 2013
  5. pmc Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant
    Marco Henkel
    Institute of Immunology, Federal Research Centre for Virus Diseases of Animals, Tuebingen, Germany
    J Virol 79:314-25. 2005
  6. ncbi Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism
    M V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Behav Brain Res 100:43-50. 1999
  7. ncbi Sequence characterization of human Borna disease virus
    J C de La Torre
    Viral Immunology Laboratory, Scripps Research Institute 92037 CA, USA
    Virus Res 44:33-44. 1996
  8. pmc TNF-overexpression in Borna disease virus-infected mouse brains triggers inflammatory reaction and epileptic seizures
    Katharina Kramer
    Department of Pathology, University of Veterinary Medicine, Hannover, Germany
    PLoS ONE 7:e41476. 2012
  9. pmc Borna disease virus infects human neural progenitor cells and impairs neurogenesis
    Dragan Brnic
    INRA, Anses, ENVA, UMR 1161, Maisons Alfort, France
    J Virol 86:2512-22. 2012
  10. ncbi Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus
    C Herden
    Institut fur Pathologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Neuropathol Appl Neurobiol 31:512-21. 2005

Research Grants

  1. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
  2. BORNA VIRUS--AN EMERGING NEUROTROPIC PATHOGEN IN HUMANS
    JUAN DE LA TORRE; Fiscal Year: 2000
  3. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 1999
  4. BORNA DISEASE VIRUS--CLONING OF ORF-5 CDNAS
    Patrick Lai; Fiscal Year: 1999
  5. BORNA DISEASE USING NUCLEIC ACID PROBES
    Bernhard Dietzschold; Fiscal Year: 1993
  6. IRC--CLASSIFICATION AND COURSE OF SCHIZOPHRENIAS
    William Carpenter; Fiscal Year: 2002
  7. VIRUSES NEUROTRANSMITTERS AND NEUROLOGICAL DISEASES
    WALTER LIPKIN; Fiscal Year: 1991
  8. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 2002
  9. Viral neuropathology neuropeptides and epilepsy
    Marylou Solbrig; Fiscal Year: 2005
  10. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005

Detail Information

Publications203 found, 100 shown here

  1. ncbi Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland
    Paula M Kinnunen
    Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, P O Box 66, 00014 University of Helsinki, Finland
    J Clin Virol 38:64-9. 2007
    b>Borna disease virus (BDV) can infect many vertebrate species, including humans. BDV infection may lead to meningoencephalomyelitis in animals...
  2. pmc Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells
    Rongzhong Huang
    Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    PLoS ONE 7:e44665. 2012
    b>Borna disease virus is a neurotropic, non-cytolytic virus that has been widely employed in neuroscientific research. Previous studies have revealed that metabolic perturbations are associated with Borna disease viral infection...
  3. ncbi Experimental vertical transmission of Borna disease virus in the mouse
    M Okamoto
    Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Arch Virol 148:1557-68. 2003
    We demonstrated the experimental vertical transmission of Borna disease virus (BDV) in pregnant BALB/c mice. Giessen strain He/80 of BDV was used in the present study...
  4. ncbi Epidemiology and host spectrum of Borna disease virus infections
    Paula M Kinnunen
    Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Finland
    J Gen Virol 94:247-62. 2013
    b>Borna disease virus (BDV) has gained lot of interest because of its zoonotic potential, ability to introduce cDNA of its RNA transcripts into host genomes, and ability to cause severe neurobehavioural diseases...
  5. pmc Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant
    Marco Henkel
    Institute of Immunology, Federal Research Centre for Virus Diseases of Animals, Tuebingen, Germany
    J Virol 79:314-25. 2005
    ..Orf virus strain D1701 was used to generate a recombinant virus (D1701-VrVp40) expressing nucleoprotein p40 of Borna disease virus, which represents a major antigen for the induction of a Borna disease virus-specific humoral and ..
  6. ncbi Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism
    M V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Behav Brain Res 100:43-50. 1999
    ..were observed in male juvenile Lewis rats with brain developmental injury following neonatal infection with Borna disease virus (BDV)...
  7. ncbi Sequence characterization of human Borna disease virus
    J C de La Torre
    Viral Immunology Laboratory, Scripps Research Institute 92037 CA, USA
    Virus Res 44:33-44. 1996
    b>Borna disease virus (BDV) causes a central nervous system disease in several vertebrate animal species, which is manifest by behavioral abnormalities...
  8. pmc TNF-overexpression in Borna disease virus-infected mouse brains triggers inflammatory reaction and epileptic seizures
    Katharina Kramer
    Department of Pathology, University of Veterinary Medicine, Hannover, Germany
    PLoS ONE 7:e41476. 2012
    Proinflammatory state of the brain increases the risk for seizure development. Neonatal Borna disease virus (BDV)-infection of mice with neuronal overexpression of tumor necrosis factor-α (TNF) was used to investigate the complex ..
  9. pmc Borna disease virus infects human neural progenitor cells and impairs neurogenesis
    Dragan Brnic
    INRA, Anses, ENVA, UMR 1161, Maisons Alfort, France
    J Virol 86:2512-22. 2012
    ..The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms...
  10. ncbi Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus
    C Herden
    Institut fur Pathologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Neuropathol Appl Neurobiol 31:512-21. 2005
    Experimental infection of Lewis rats with Borna disease virus (BDV) causes an immune-mediated nonpurulent meningoencephalitis...
  11. pmc Borna disease virus infection, a human mental-health risk
    Liv Bode
    Project Bornavirus Infections, Robert Koch Institute, 13353 Berlin, Germany
    Clin Microbiol Rev 16:534-45. 2003
    This article focuses on human Borna disease virus (BDV) infections, most notably on the development of valid diagnostic systems, which have arisen as a major research issue in the past decade...
  12. pmc Persistence of Borna disease virus in naturally infected sheep
    Thomas W Vahlenkamp
    Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany
    J Virol 76:9735-43. 2002
    To get an insight into Borna disease virus (BDV) epidemiology, an isolated flock of approximately 25 sheep within the region of Southeast Germany to which the disease is endemic was investigated over a 3-year observation period...
  13. ncbi Detection of Borna disease virus in a pregnant mare and her fetus
    K Hagiwara
    School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
    Vet Microbiol 72:207-16. 2000
    ..mare showing pyrexia, reduced appetite, ataxia and paresis was euthanized and examined for the presence of Borna disease virus (BDV)...
  14. pmc Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:16. 2008
    Neonatal Borna Disease Virus (BDV) infection in rats leads to a neuronal loss in the cortex, hippocampus and cerebellum...
  15. pmc Borna disease in a dog with lethal meningoencephalitis
    H Weissenbock
    Institute of Pathology and Forensic Veterinary Medicine, University of Veterinary Medicine, Vienna, Austria
    J Clin Microbiol 36:2127-30. 1998
    ..By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog...
  16. ncbi Investigation of frequency of active Borna disease virus infection in Scottish blood donors
    F Davidson
    Scottish National Blood Transfusion Service, Transfusion Transmitted Infection Group, Edinburgh, UK
    Vox Sang 86:148-50. 2004
    b>Borna disease virus (BDV) can infect a wide range of vertebrate species causing neurological disease. In order to ensure the safety of blood supplies, it is essential to monitor blood for emerging pathogens.
  17. ncbi Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Mol Psychiatry 4:566-71. 1999
    Accumulating evidence suggests that Borna disease virus (BDV), a neurotropic, negative-stranded RNA virus, might be associated with certain human mental disorders...
  18. ncbi Prevalence of circulating antibodies to p10, a non-structural protein of the Borna disease virus in cats with ataxia
    A Ouchi
    Tsukuba Central Laboratories, Kyoritsu Seiyaku Corporation, Inashiki-gun, Ibaraki, Japan
    J Vet Med Sci 63:1279-85. 2001
    Japanese domestic cats were surveyed for circulating antibodies to the plO and p24 proteins of the Borna disease virus (BDV) by Western blotting. Twenty-four of 52 cats (46...
  19. ncbi Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice
    Jürgen Hausmann
    Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
    J Gen Virol 86:399-403. 2005
    b>Borna disease virus (BDV) can persistently infect the central nervous system and induce CD8+ T-cell-mediated neurological disease in MRL mice...
  20. ncbi Detection of antibodies to Borna disease virus in Turkish cats by using recombinant p40
    C R Helps
    Department of Clinical Veterinary Science, University of Bristol, Langford
    Vet Rec 149:647-50. 2001
    ..Antibodies to Borna disease virus- (BDV) p40 were detected in 34 (42-5 per cent) of the 80 cats...
  21. ncbi Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients
    Helen Cristina Miranda
    Department of Pathological Sciences Immunology, Londrina State University, Londrina, PR, Brazil
    J Affect Disord 90:43-7. 2006
    b>Borna disease virus (BDV) is a virus that naturally infects a broad range of warm-blooded animals...
  22. pmc CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage
    Jürgen Hausmann
    Department of Virology, Bavarian Nordic GmbH, Fraunhoferstrasse 13, D 82152 Martinsried, Germany
    J Virol 79:13509-18. 2005
    b>Borna disease virus (BDV) frequently causes meningoencephalitis and fatal neurological disease in young but not old mice of strain MRL. Disease does not result from the virus-induced destruction of infected neurons...
  23. ncbi Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies--the key marker triplet determining infection and prevailing in severe mood disorders
    L Bode
    Project Bornavirus Infections, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Mol Psychiatry 6:481-91. 2001
    b>Borna disease virus (BDV), a unique genetically highly conserved RNA virus (Bornaviridae; Mononegavirales), preferentially targets neurons of limbic structures causing behavioral abnormalities in animals...
  24. pmc CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforin
    J Hausmann
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79104 Freiburg, Germany
    J Virol 75:10460-6. 2001
    ..perforin in a mouse model for CD8(+) T-cell-mediated central nervous system (CNS) immunopathology induced by Borna disease virus...
  25. ncbi Antibodies to borna disease virus in subacute sclerosing panencephalitis
    Serdal Gungor
    Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Infect Dis J 24:833-4. 2005
    ..b>Borna disease virus (BDV) frequently causes latent or persistent infection in the nervous system...
  26. ncbi Detection of anti-borna disease virus antibodies from cats in Asian countries, Japan, Philippines and Indonesia using electrochemiluminescence immunoassay
    Y Horii
    Department of Internal Medicine, Veterinary Teaching Hospital and Faculty of Agriculture, Miyazaki University, Gakuen-Kibanadai, Japan
    J Vet Med Sci 63:921-3. 2001
    Anti-Borna disease virus (BDV) antibodies were detected from cats in Japan, Philippines and Indonesia by using electrochemiluminescence immunoassay. Positive rates were 3.1%, 3.8% and 2...
  27. ncbi RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives
    Sandra Odebrechet Vargas Nunes
    Department of Psychiatry, State University of Londrina, Londrina, PR, Brazil
    J Clin Lab Anal 22:314-20. 2008
    ..Detection of p24 RNA from Borna disease virus (BDV) by the reverse transcriptase polymerase chain reaction in patients with schizophrenia, ..
  28. ncbi Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells
    A Hans
    , CNRS URA 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    J Biol Chem 276:7258-65. 2001
    Persistence of Borna disease virus (BDV) in the central nervous system causes damage to specific neuronal populations. BDV is noncytopathic, and the mechanisms underlying neuronal pathology are not well understood...
  29. pmc Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice
    Markus Hofer
    Abteilung Neuropathologie, Institut für Medizinische and Hygiene, Universitat Freiburg, Freiburg, Germany
    Am J Pathol 165:949-58. 2004
    ..Infection with noncytolytic Borna disease virus (BDV) did not affect wild-type mice but accelerated disease of IL-12 transgenic mice...
  30. ncbi Two domains of the Borna disease virus p40 protein are required for interaction with the p23 protein
    M Berg
    Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala
    J Gen Virol 79:2957-63. 1998
    b>Borna disease virus (BDV) has five major open reading frames, which encode the proteins p40, p23, gp18, p57 and p190. By analogy with other negative-strand RNA viruses, p40 is a putative nucleoprotein and p23 is a putative phosphoprotein...
  31. ncbi [Detection of anti-Borna disease virus antibodies in patients hospitalized in psychiatric hospitals located in the mid-Western region of Poland]
    F Rybakowski

    Psychiatr Pol 35:819-29. 2001
    b>Borna Disease Virus (BDV) is single stranded RNA virus, which may infect a wide range of animal species. Manifestations of the experimental BDV infection show some resemblance to psychopathological symptoms of mental disorders in humans...
  32. ncbi Markers of Borna disease virus infection in cats with staggering disease
    Jonas J Wensman
    Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Feline Med Surg 14:573-82. 2012
    b>Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease...
  33. pmc Intracerebral Borna disease virus infection of bank voles leading to peripheral spread and reverse transcription of viral RNA
    Paula Maria Kinnunen
    Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e23622. 2011
    ..The epidemiology of Borna disease virus (BDV), as for other members of the family Bornaviridae, is largely unknown, although evidence exists for ..
  34. ncbi Borna disease in an adult alpaca stallion (Lama pacos)
    B Jacobsen
    Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    J Comp Pathol 143:203-8. 2010
    b>Borna disease (BD) was diagnosed in a 2-year-old male alpaca with a history of chronic suppressed sexual desire and acute stretching convulsions...
  35. pmc Detection of borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay
    K Yamaguchi
    Blood Transfusion Service and Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Clin Diagn Lab Immunol 6:696-700. 1999
    The prevalence of Borna disease virus (BDV)-specific antibodies among patients with psychiatric disorders and healthy individuals has varied in several reports using several different serological assay methods...
  36. ncbi Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus
    Marylou V Solbrig
    Department of Neurology and Pharmacology, University of California at Irvine, 3107 Gillespie Neuroscience Research Building, Irvine, CA 92697 4292, USA
    Pharmacol Biochem Behav 74:777-87. 2003
    b>Borna Disease Virus (BDV) is a neurotropic RNA virus that is worldwide in distribution, causing movement and behavior disorders in a wide range of animal species...
  37. ncbi Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum
    Mikhail V Ovanesov
    Division of Neurobiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 13:185-94. 2007
    The authors evaluated a role of glutamate (GLU) excitotoxicity in neonatal Borna disease virus (BDV) infection-associated neuronal injury by measuring extracellular levels of GLU in the striatum of 70-day-old Fischer344 rats using in ..
  38. ncbi Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats
    M V Pletnikov
    Laboratory of Pediatric and Respiratory Viral Diseases, CBER, FDA, Bethesda, MD 20892, USA
    Physiol Behav 66:823-31. 1999
    Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum...
  39. ncbi Postnatal weight gain inhibition does not account for neurobehavioral consequences of neonatal Borna disease virus infection
    David M Dietz
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Physiol Behav 80:359-66. 2003
    Neonatal Borna disease virus (BDV) infection of the rat's brain produces neurodevelopmental damage similar to some pathological and clinical features of human developmental disorders, e.g., autism and schizophrenia...
  40. pmc Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12
    Gregor Friedl
    Abteilung Neuropathologie, Pathologisches Institut, Universitat Freiburg, D 79106 Freiburg, Germany
    J Virol 78:1212-8. 2004
    b>Borna disease virus (BDV) induces a nonpurulent CD4- and CD8-T-cell-dependent meningoencephalitis in susceptible animals...
  41. ncbi Neurological disorder after Borna disease virus infection in the absence of either interferon-gamma, Fas, inducible NO synthase, or chemokine receptor CXCR3
    Jürgen Hausmann
    Department of Virology, University of Freiburg, Freiburg, Germany
    Viral Immunol 17:79-85. 2004
    b>Borna disease virus (BDV) can induce severe neurological disorder in Lewis rats and MRL mice. Antiviral CD8 T cells have been shown to be the mediators of disease in these animals...
  42. ncbi Gene expression of the TGF-beta family in rat brain infected with Borna disease virus
    Yoshii Nishino
    Laboratory of Veterinary Immunology, Azabu University School of Veterinary Medicine, Sagamihara 229 8501, Japan
    Microbes Infect 11:737-43. 2009
    CRNP5, a variant of Borna disease virus (BDV), has stronger pathogenesis in rats than the related variant CRP3, although only 4 amino acids in the whole genome are different...
  43. pmc Borna disease virus infection in animals and humans
    J A Richt
    Institut fur Virologie, Giessen, Germany
    Emerg Infect Dis 3:343-52. 1997
    The geographic distribution and host range of Borna disease (BD), a fatal neurologic disease of horses and sheep, are larger than previously thought...
  44. ncbi [The neuropathogenesis of Borna disease virus infection]
    K Tomonaga
    Department of Virology, Research Institute for Microbial Diseases, Osaka University
    Nippon Rinsho 59:1605-13. 2001
    b>Borna disease virus(BDV) is a noncytolytic, neurotropic RNA virus that causes a disease of the central nervous system(CNS) in several vertebrate species, including horses, sheep, cats and ostriches...
  45. pmc Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:50. 2008
    Neonatal Borna disease virus (BDV) infection of the rat brain is associated with microglial activation and damage to certain neuronal populations...
  46. ncbi Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration
    Michael Bacher
    Institute of Immunology, Philipps University, Marburg, Germany
    Glia 37:291-306. 2002
    ..invasion during virus-induced encephalitis, we analyzed the expression and cellular localization of MIF in the Borna disease virus (BDV)-infected rat brain, monitored monocyte/macrophage infiltration, and evaluated the influence of ..
  47. ncbi Detection of antibodies to Borna disease virus (BDV) in Turkish horse sera using recombinant p40. Brief report
    H Yilmaz
    University of Istanbul, Veterinary Faculty, Department of Microbiology, Avcilar, Turkey
    Arch Virol 147:429-35. 2002
    The nucleoprotein of Borna disease virus (BDV-p40) was produced in a Baculovirus expression system using sf9 cells. The purity and specificity of the recombinant p40 was confirmed by SDS-PAGE and immunoblotting...
  48. ncbi Experimental infection of mice with Borna disease virus (BDV): replication and distribution of the virus after intracerebral infection
    H K Enbergs
    Institute of Virology, Faculty of Veterinary Medicine, Leipzig, Germany
    J Neurovirol 7:272-7. 2001
    To develop an animal model resembling natural asymptomatic Borna disease virus (BDV) infections, BDV He/80 rat brain homogenate was passaged four times in adult SJL/J mice...
  49. pmc Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats
    Marion Poenisch
    Department of Virology, University of Freiburg, Freiburg, Germany
    J Virol 83:4297-307. 2009
    b>Borna disease virus (BDV) is a neurotropic member of the order Mononegavirales with noncytolytic replication and obligatory persistence in cultured cells and animals...
  50. pmc Visualizing viral dissemination in the mouse nervous system, using a green fluorescent protein-expressing Borna disease virus vector
    Andreas Ackermann
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 84:5438-42. 2010
    b>Borna disease virus (BDV) frequently persists in the brain of infected animals. To analyze viral dissemination in the mouse nervous system, we generated a mouse-adapted virus that expresses green fluorescent protein (GFP)...
  51. ncbi Borna disease virus: a mystery as an emerging zoonotic pathogen
    J A Richt
    Institut fur Virologie, Frankfurterstrasse 107, D 35392 Giessen, Germany
    Vet J 161:24-40. 2001
    For Central European veterinarians, Borna disease (BD) has been known for a long time as a sporadically occurring, progressive viral polioencephalomyelitis predominantly affecting horses and sheep and-as discovered in the last decade-an ..
  52. ncbi Distribution of Borna disease virus antigen and RNA in tissues of naturally infected bicolored white-toothed shrews, Crocidura leucodon, supporting their role as reservoir host species
    M E Puorger
    University of Zurich, Zurich, Switzerland
    Vet Pathol 47:236-44. 2010
    b>Borna disease is a severe viral-induced disorder of the central nervous system of horses, sheep, and a few other animal species, occurring in certain areas of central Europe...
  53. pmc Borna disease in a free-ranging lynx (Lynx lynx)
    M P Degiorgis
    Department of Wildlife, National Veterinary Institute, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Clin Microbiol 38:3087-91. 2000
    ..In situ hybridization, immunohistochemistry, and reverse transcriptase PCR analysis showed the presence of Borna disease virus infection in the brain...
  54. ncbi Anti-Borna disease virus antibody responses in psychiatric patients: long-term follow up
    Alexander Heinrich
    Department of Neurology and Clinical Neurophysiology, Henriettenstiftung Hannover, Hannover, Germany
    Psychiatry Clin Neurosci 64:255-61. 2010
    Data suggesting a pathogenetic role for Borna disease virus (BDV) in neuropsychiatric diseases are still inconclusive and it is unknown whether humans become persistently infected or clear the virus infection...
  55. ncbi Seroprevalence of Borna disease virus in domestic animals in Xinjiang, China
    K Hagiwara
    School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyoudai Midorimachi Ebetsu, 069 8501, Hokkaido, Japan
    Vet Microbiol 80:383-9. 2001
    To investigate the animals infected with Borna disease virus (BDV) in Xinjiang, China, we examined for BDV antibodies in the sera from groups of 20 horses, sheep and cattle, and from 165 wild rodents (18 species) by ELISA and immunoblot...
  56. ncbi Borna disease virus and mental health: a cross-sectional study
    D Rh Thomas
    NPHS Communicable Disease Surveillance Centre, Abton House, Wedal Road, Cardiff CF14 3QX, UK
    QJM 98:247-54. 2005
    b>Borna disease is an infectious neurological disease of horses, sheep and possibly other animals...
  57. pmc Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1
    Gunhild Unterstab
    Robert Koch Institute, FG12, Nordufer 20, 13353 Berlin, Germany
    Proc Natl Acad Sci U S A 102:13640-5. 2005
    ..b>Borna disease virus (BDV) establishes persistent noncytolytic infections in animals and tissue culture cells, indicating ..
  58. pmc Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection
    Brent L Williams
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, 722 West 168th Street, Rm 1801, New York, NY 10032, USA
    J Virol 81:2675-87. 2007
    Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life...
  59. pmc Borna disease virus blocks potentiation of presynaptic activity through inhibition of protein kinase C signaling
    Romain Volmer
    Avenir Group, INSERM, U563, Toulouse, France
    PLoS Pathog 2:e19. 2006
    Infection by Borna disease virus (BDV) enables the study of the molecular mechanisms whereby a virus can persist in the central nervous system and lead to altered brain function in the absence of overt cytolysis and inflammation...
  60. ncbi Kappa opioid control of seizures produced by a virus in an animal model
    Marylou V Solbrig
    Department of Neurology, University of California Irvine, Irvine, CA 92697 4292, USA
    Brain 129:642-54. 2006
    ..Encephalitis produced by the neurotropic Borna disease virus in the rat caused epileptic responses and dynorphin to disappear via dentate granule cell loss, failed ..
  61. ncbi The use of peptide arrays for the characterization of monospecific antibody repertoires from polyclonal sera of psychiatric patients suspected of infection by Borna Disease Virus
    Martin Schwemmle
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Mol Divers 8:247-50. 2004
    b>Borna Disease Virus (BDV) is suspected to infect humans and to be associated with psychiatric disorders. To this date, BDV-reactive antibodies provide the only reliable markers to diagnose human BDV infection...
  62. pmc Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 78:3621-32. 2004
    The nucleoprotein (N) of Borna disease virus (BDV) is the major target of the disease-inducing antiviral CD8 T-cell response in the central nervous system of mice...
  63. ncbi Demonstration of continuously seropositive population against Borna disease virus in Misaki feral horses, a Japanese strain: a four-year follow-up study from 1998 to 2001
    Yoichi Inoue
    Department of Veterinary Teaching Hospital and Internal Medicine, Faculty of Agriculture, Miyazaki University, Gakuen KibanaDai, Japan
    J Vet Med Sci 64:445-8. 2002
    b>Borna disease virus (BDV)-specific antibodies were monitored in Misaki feral horses annually for 4 years using an electrochemiluminescence immunoassay (ECLIA). Among 130 horses examined, 35 (26...
  64. pmc Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus
    B L Williams
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Virol 80:8613-26. 2006
    b>Borna disease virus infection of neonatal rats results in a characteristic behavioral syndrome and apoptosis of subsets of neurons in the hippocampus and cerebellum (neonatal Borna disease [NBD])...
  65. pmc Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan
    K Fukuda
    Department of Microbiology, Fukushima Medical University, Fukushima-shi, Fukushima 960-1295, Japan
    J Clin Microbiol 39:419-29. 2001
    The involvement of Borna disease virus (BDV) in psychiatric diseases in humans remains controversial...
  66. pmc Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity
    Christine M A Prat
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan and Université Paul Sabatier, Toulouse, France
    PLoS Pathog 5:e1000425. 2009
    ..b>Borna disease virus (BDV) represents an attractive model system to analyze the molecular mechanisms whereby a virus can ..
  67. pmc Alpha/beta interferon promotes transcription and inhibits replication of borna disease virus in persistently infected cells
    P Staeheli
    Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 75:8216-23. 2001
    b>Borna disease virus (BDV) is a noncytolytic RNA virus that can replicate in the central nervous system (CNS) of mice...
  68. pmc Borna disease virus infection impairs synaptic plasticity
    Romain Volmer
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, 31024 Toulouse Cedex 3, France
    J Virol 81:8833-7. 2007
    The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood...
  69. pmc Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus
    Naohiro Ohtaki
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Virol 81:5940-8. 2007
    b>Borna disease virus (BDV) is a neurotropic virus that causes a persistent infection in the central nervous system (CNS) of many vertebrate species...
  70. ncbi Development of a real-time RT-PCR assay for improved detection of Borna disease virus
    Jonas Johansson Wensman
    Joint Research and Development Division in Virology of National Veterinary Institute SVA, Swedish University of Agricultural Sciences SLU, Uppsala, Sweden
    J Virol Methods 143:1-10. 2007
    b>Borna disease virus (BDV) is a non-segmented, negative-stranded RNA virus, which infects cells of the central nervous system (CNS) in many different species...
  71. pmc Isolation and characterization of a new subtype of Borna disease virus
    N Nowotny
    Institute of Virology, University of Veterinary Sciences, Vienna, A 1210 Vienna, Austria
    J Virol 74:5655-8. 2000
    b>Borna disease virus (BDV), the causative agent of severe meningoencephalitis in a wide variety of animal species, has been considered to be genetically invariable and to form a single type within the genus Bornavirus of the family ..
  72. ncbi Borna disease virus interference with neuronal plasticity
    Daniel Gonzalez-Dunia
    Avenir Group, INSERM U563, CPTP Bat B, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Virus Res 111:224-34. 2005
    ..The mechanisms whereby such infections disturb brain functions are beginning to emerge. Borna disease virus (BDV), which causes a persistent infection of neurons without direct cytolysis in several mammalian ..
  73. ncbi Neurological diseases and viral dynamics in the brains of neonatally borna disease virus-infected gerbils
    M Watanabe
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Virology 282:65-76. 2001
    b>Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that causes a chronic neurological disease in a wide variety of animal species...
  74. pmc High-dose Borna disease virus infection induces a nucleoprotein-specific cytotoxic T-lymphocyte response and prevention of immunopathology
    E Furrer
    , , , Germany
    J Virol 75:11700-8. 2001
    Experimental Borna disease virus (BDV) infection of rats and natural infection of horses and sheep leads to severe central nervous system disease based on immunopathological pathways...
  75. ncbi No evidence of endemic Borna disease virus infection in Australian horses in contrast with endemic infection in other continents
    S Kamhieh
    Northern Blood Research Centre, St Leonards, NSW, Australia
    Arch Virol 151:709-19. 2006
    b>Borna disease virus (BDV) is a unique RNA virus that is a cause of neurological disease in horses, sheep and cats. The finding that BDV also infects humans has raised concern related to the impact of infection with this virus...
  76. ncbi Meta-analysis of putative human bornavirus sequences fails to provide evidence implicating Borna disease virus in mental illness
    Ralf Durrwald
    Impfstoffwerk Dessau Tornau GmbH IDT, Rodleben, Germany
    Rev Med Virol 17:181-203. 2007
    All Borna disease virus (BDV) sequences derived from human specimens published till date were thoroughly analysed and compared to sequences of BDV laboratory strains and to BDV sequences from animals which succumbed to classical Borna ..
  77. ncbi The immunopathogenesis of Borna disease virus infection
    Lothar Stitz
    Institute for Immunology, Federal Research Center for Virus Diseases of Animals, Paul Ehrlich Strasse 28, D 72076 Tubingen, FRG
    Front Biosci 7:d541-55. 2002
    b>Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system...
  78. ncbi Borna disease virus and the evidence for human pathogenicity: a systematic review
    R M Chalmers
    NPHS Communicable Disease Surveillance Centre, Abton House, Wedal Road, Cardiff CF14 3QX, UK
    QJM 98:255-74. 2005
    b>Borna disease is a neurological viral disease of veterinary importance in central Europe, although Borna Disease virus (BDV) has been reported to be present in animals in most continents...
  79. ncbi Borna disease virus and psychiatry
    O Taieb
    Department of Virology, CERVI, , 75013 Paris, France
    Eur Psychiatry 16:3-10. 2001
    b>Borna disease virus (BDV), a noncytolytic neurotropic nonsegmented negative-stranded RNA virus with a wide geographic distribution, infects several vertebrate animal species and causes an immune-mediated central nervous system (CNS) ..
  80. ncbi Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility
    Yohei Watanabe
    Department of Virology, Research Institute for Microbial Diseases BIKEN, Osaka University, Suita, Osaka 565 0871, Japan
    Microbes Infect 9:417-27. 2007
    To investigate the biological characteristics of field isolates of Borna disease virus (BDV), as well as to understand BDV infections outside endemic countries, we isolated the virus from brain samples of a heifer with Borna disease in ..
  81. ncbi Molecular biology of Borna disease virus and persistence
    Juan Carlos de la Torre
    Department of Neuropharmacology, Division of Virology, IMM 6, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Front Biosci 7:d569-79. 2002
    b>Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities...
  82. ncbi Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficits
    Mikhail V Pletnikov
    Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 944:97-107. 2002
    ..In the two consecutive papers, we used the neonatal Borna disease virus (BDV) infection rat model of neurodevelopmental damage to evaluate brain pathology, monoamine ..
  83. ncbi Molecular and cellular biology of Borna disease virus infection
    Keizo Tomonaga
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Microbes Infect 4:491-500. 2002
    b>Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that causes neurobehavioral disorders in a wide variety of warm-blooded animals...
  84. pmc Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components
    Till Geib
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Virol 77:4283-90. 2003
    ..We present evidence for superinfection exclusion in brains of Borna disease virus (BDV)-infected rats and in persistently infected Vero cells, and we suggest that acquired resistance to ..
  85. ncbi Humoral immune response against Borna disease virus (BDV) in experimentally and naturally infected cats
    M Johansson
    Department of Pathology, Swedish University of Agricultural Sciences SUAS, 750 07, Uppsala, Sweden
    Vet Immunol Immunopathol 90:23-33. 2002
    In order to investigate the peripheral and intracerebral humoral immune response against Borna disease virus (BDV) in cats, serum and cerebrospinal fluid (CSF) samples from experimentally and naturally BDV-infected cats were analysed in ..
  86. pmc Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation
    C Sauder
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79104 Freiburg
    J Virol 74:9267-80. 2000
    b>Borna disease virus (BDV) causes CD8(+) T-cell-mediated meningoencephalitis in immunocompetent mice and rats, thus providing a valuable animal model for studying the mechanisms of virus-induced central nervous system (CNS) ..
  87. pmc Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules
    Roberto Clemente
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 83:10406-16. 2009
    b>Borna disease virus (BDV), the prototypic member of the Bornaviridae family within the order Mononegavirales, exhibits high neurotropism and provides an important and unique experimental model system for studying virus-cell interactions ..
  88. ncbi Borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the Czech Republic
    Sylva Rackova
    Department of Psychiatry, University Hospital, Medical Faculty, Charles University in Pilsen, Alej Svobody 80, Pilsen, Czech Republic
    Neuro Endocrinol Lett 30:414-20. 2009
    b>Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. BDV is a neurotropic virus that causes changes in mood, behaviour and cognition...
  89. ncbi Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis
    David Dietz
    Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland 21205, USA
    J Neurovirol 10:267-77. 2004
    Neonatal Borna disease virus (BDV) infection of the rat brain serves as a valuable model for studying the pathogenesis of neurodevelopmental abnormalities following early brain injury...
  90. ncbi Susceptibility of Borna disease virus to the antiviral action of gamma-interferon: evidence for species-specific differences
    C Sauder
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Medical School, Freiburg, Germany
    Arch Virol 149:2171-86. 2004
    b>Borna disease virus (BDV) infection in its predominant natural host - horses and sheep - leads to fatal meningoencephalomyelitis...
  91. ncbi Viral accessory protein X stimulates the assembly of functional Borna disease virus polymerase complexes
    Marion Poenisch
    Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
    J Gen Virol 89:1442-5. 2008
    The Borna disease virus (BDV) proteins X and P are translated from a bicistronic viral mRNA...
  92. ncbi Infection of the enteric nervous system by Borna disease virus (BDV) upregulates expression of Calbindin D-28k
    Helga Pfannkuche
    Institute of Veterinary Physiology, Faculty of Veterinary Medicine, An den Tierkliniken 7, Leipzig University, 04103 Leipzig, Germany
    Vet Microbiol 127:275-85. 2008
    b>Borna disease virus (BDV) is a neurotropic agent infecting distinct neuronal subpopulations in the central nervous system of various mammalian species possibly including humans...
  93. ncbi Sero-epidemiological study of Borna disease virus infection in the Italian equine population
    G Pisoni
    Department of Veterinary Pathology, Hygiene and Public Health, Institute of Infectious Diseases, University of Milan, Milan, Italy
    Vet Res Commun 31:245-8. 2007
  94. pmc Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication
    Soizic Bourteele
    Institut fur Immunologie, Friedrich Loeffler Institut, Bundesforschungsinstitut für Tiergesundheit, Paul Ehrlich Str 28, 72076 Tubingen, Germany
    J Virol 79:6043-51. 2005
    ..b>Borna disease virus (BDV) is a neurotropic negative-strand RNA virus, which replicates in the nucleus of the infected cell ..
  95. ncbi Reverse transcription real-time PCR assays for detection and quantification of Borna disease virus in diseased hosts
    A R Schindler
    Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 266a, CH 8057 Zurich, Switzerland
    Mol Cell Probes 21:47-55. 2007
    b>Borna disease is a severe, immunopathological disorder of the central nervous system caused by the infection with the Borna disease virus (BDV)...
  96. pmc Shrews as reservoir hosts of borna disease virus
    Monika Hilbe
    University of Zurich, Zurich, Switzerland
    Emerg Infect Dis 12:675-7. 2006
    b>Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other animal species in central Europe...
  97. pmc Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation
    K M Carbone
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Virol 61:3431-40. 1987
    b>Borna disease virus is an uncharacterized agent that causes sporadic but fatal neurological disease in horses and sheep in Europe...
  98. ncbi Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Neurovirol 8:168-79. 2002
    Infection of adult rats with Borna disease virus (BDV) causes CD8 T cell-mediated meningoencephalitis. Previously, we described a complex pattern of chemokine gene expression in the central nervous system (CNS) of such rats...
  99. ncbi Bornavirus and the brain
    Juan Carlos de la Torre
    Department of Neuropharmacology, Division of Virology, IMM 6, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Infect Dis 186:S241-7. 2002
    b>Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities. BDV is a nonsegmented, negative, single-stranded RNA virus...
  100. ncbi Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders
    Mikhail V Pletnikov
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Front Biosci 7:d593-607. 2002
    ..The present review provides a detailed analysis of a new animal model of ASD. This model utilizes neonatal Borna disease virus (BDV) infection of the rat brain as a unique experimental teratogen to study the pathogenesis of ..
  101. ncbi Conservation of coding potential and terminal sequences in four different isolates of Borna disease virus
    S Pleschka
    Institute of Virology, University of Giessen, D-35392 Giessen, Germany
    J Gen Virol 82:2681-90. 2001
    We determined the complete nucleotide sequences of two poorly characterized strains of Borna disease virus (BDV) and compared them to reference strains V and He/80...

Research Grants31

  1. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
    DESCRIPTION (Applicant's Abstract): Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warm blooded animals to cause disturbances of movement and behavior...
  2. BORNA VIRUS--AN EMERGING NEUROTROPIC PATHOGEN IN HUMANS
    JUAN DE LA TORRE; Fiscal Year: 2000
    ..b>Borna disease virus (BDV) causes central nervous system (CNS) disease in several vertebrate species which is characterized ..
  3. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 1999
    ..of all proteins of paramyxo-, rhabdo- and filoviruses, (with privileged access to new Ebola sequences), and Borna Disease virus, (including potential BDV sequences from schizophrenic patients); and 3) the analysis of the dUTPase ..
  4. BORNA DISEASE VIRUS--CLONING OF ORF-5 CDNAS
    Patrick Lai; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Applicant's Abstract): The Borna disease virus (BDV) is an enveloped, negative, non-segmented, single stranded (NNS), RNA virus...
  5. BORNA DISEASE USING NUCLEIC ACID PROBES
    Bernhard Dietzschold; Fiscal Year: 1993
    ..Since Borna disease (BD) virus has a specific affinity for those brain areas thought to be involved with depression (e.g...
  6. IRC--CLASSIFICATION AND COURSE OF SCHIZOPHRENIAS
    William Carpenter; Fiscal Year: 2002
    ..and etiologically relevant data on season of birth, pathology in biological relatives, and seropositivity for borna disease virus...
  7. VIRUSES NEUROTRANSMITTERS AND NEUROLOGICAL DISEASES
    WALTER LIPKIN; Fiscal Year: 1991
    ..During the last two years of this project, I will focus on Borna disease virus (BDV), an intriguing infectious agent with wide host range and tropism for selected CNS regions...
  8. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 2002
    ..An animal model of a persistent CNS viral infection based on experimental Borna disease virus infection of the rat will be developed then tested for 1) the reinforcing effects of opiates as measured ..
  9. Viral neuropathology neuropeptides and epilepsy
    Marylou Solbrig; Fiscal Year: 2005
    ..The generality of the hypothesis, the mechanism of effect, and treatments will be studied. Borna Disease virus, a neurotropic virus causing hippocampal degeneration in many mamma an species, is a rare cause of ..
  10. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  11. Identification of Borna Disease Virus Receptor Proteins
    JUAN DE LA TORRE; Fiscal Year: 2006
    b>Borna disease virus (BDV) is an enveloped virus with a non-segmented negative strand (NNS) RNA genome. Because of its unique features BDV is the prototypic member of a new virus family...
  12. Neuroimmunologic Disorders Induced by Chronic Viral Infection
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..We will use biochemical, genetics and functional assays to assess the relevance in Arenavirus biology of candidates initially identified by TAP/MS. ..
  14. Anti-interferon Activity of the Arenavirus Nucleoprotein
    JUAN DE LA TORRE; Fiscal Year: 2008
    ..abstract_text> ..
  15. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  16. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  17. Novel Antiviral Strategy to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..abstract_text> ..
  18. Aminoglycoside Antivirals to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..Emergence of resistant variants will be assessed based on production of infectious virus and intracellular levels of virus RNA synthesis during serial passages in the presence of aminoglycosides with anti-LCMV activity. ..
  19. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..and either affective disorders or schizophrenia, a potential role in their pathogenesis has been suggested for Borna disease virus (BDV)...
  20. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular ..
  21. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2004
    b>Borna disease virus (BDV) provides an important model for the study of viral persistence4n the central nervous system (CNS), a subject relevant to health given the evidence that viruses can contribute to slowly progressive human ..
  22. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..This project will explore an animal model of autism based on CNS infection in early life. Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warmblooded animals to cause disturbances ..
  23. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  24. Biology of Animal Nuclear Mononegaviruses
    JUAN DE LA TORRE; Fiscal Year: 2008
    b>Borna disease virus (BDV) is an important model for the study of viral persistence in the central nervous system (CNS), a subject relevant to health because viruses can contribute to human neurologic disease...
  25. Immune cell dynamics during central nervous system viral infection
    Juan C de la Torre; Fiscal Year: 2010
    ..abstract_text> ..
  26. Viral Pathogenesis of Neural and Behavior Injury
    Mikhail Pletnikov; Fiscal Year: 2008
    ..continuation application, we propose to use our small animal model of viral neuropathogenesis, neonatal Borna disease virus infection (BDV), to study the mechanisms by which soluble neurotoxins (e.g...
  27. EVOLUTION OF VIRULENCE OF EQUINE INFECTIOUS ANEMIA VIRUS
    Susan Payne; Fiscal Year: 2002
    ..The EIAV system provides an excellent and tractable experimental model for study of evolutionary change in retroviruses, and for understanding the evolution and determinants of virulence. ..
  28. Lentiviral Diseases: EIAV Pathogenesis
    SUSAN LYNNE PAYNE; Fiscal Year: 2010
    ....
  29. Inducible expression of mutant DISC1: transgenic mouse model
    Mikhail Pletnikov; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Adenovirus & Human Obesity - Longitudinal & Twin Studies
    Richard Atkinson; Fiscal Year: 2001
    ..The potential impact on worldwide public health may be enormous. ..
  31. Assembly of the negative stranded RNA virus core
    Ming Luo; Fiscal Year: 2010
    ..M was copurified with the P-N-RNA complex. Crystallization and cryoEM studies of this complex are in progress. The result will show how M may interact with the N-RNA complex, and perhaps with P as well. ..