experimental radiation injuries

Summary

Summary: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.

Top Publications

  1. ncbi Radioprotection of Swiss albino mouse by Centella asiatica extract
    Jaimala Sharma
    Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 16:785-6. 2002
  2. ncbi Protection of Swiss albino mice against whole-body gamma irradiation by diltiazem
    V Nunia
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    Br J Radiol 80:77-84. 2007
  3. ncbi Mechanisms of action for an anti-radiation vaccine in reducing the biological impact of high dose and dose-rate, low-linear energy transfer radiation exposure
    V Maliev
    Vladicaucasian Scientific Center, Russian Academy of Sciences, Biotechnology Departament, Russia
    Radiats Biol Radioecol 47:286-91. 2007
  4. doi An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    Lyudmila G Burdelya
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Science 320:226-30. 2008
  5. ncbi Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation
    J H Hong
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Kwei Shan, Taoyuan, Taiwan
    Int J Radiat Biol 75:1421-7. 1999
  6. ncbi Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time
    Samuel Ryu
    Department of Radiation Oncology and Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
    J Neurooncol 82:119-24. 2007
  7. ncbi The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model
    Ibrahim Kocer
    Department of Ophthalmology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey
    Graefes Arch Clin Exp Ophthalmol 245:588-94. 2007
  8. ncbi Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat
    Jae Ho Kim
    Departments of Radiation Oncology, Neurosurgery and Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    Radiat Res 161:137-42. 2004
  9. doi Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice
    Jian Zhang
    Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, East Road 305, 210002 Nanjing, People s Republic of China
    J Biomed Sci 15:585-94. 2008
  10. ncbi Maximum tolerable dose for avoidance of cataract after repeated exposure to ultraviolet radiation in rats
    Xiuqin Dong
    St Erik s Eye Hospital, Karolinska Institutet, Polhemsgatan 50, S 112 82 Stockholm, and Orebro University Hospital, Sweden
    Exp Eye Res 84:200-8. 2007

Research Grants

  1. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 1980
  2. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 1993
  3. Radiation-Induced Heart Disease: Mechanisms and Interventions
    Marjan Boerma; Fiscal Year: 2010
  4. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 2003
  5. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2007
  6. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2007
  7. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2006
  8. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2003
  9. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2001
  10. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 1999

Detail Information

Publications172 found, 100 shown here

  1. ncbi Radioprotection of Swiss albino mouse by Centella asiatica extract
    Jaimala Sharma
    Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 16:785-6. 2002
    ..Body weight loss of the animals in the drug treated group was significantly less in comparison with the animals that were given radiation only. The causes and mechanism of protection and other aspects need further investigations...
  2. ncbi Protection of Swiss albino mice against whole-body gamma irradiation by diltiazem
    V Nunia
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    Br J Radiol 80:77-84. 2007
    ..From our study it is clear that DTZ provides protection against radiation-induced haematological and biochemical alterations in Swiss albino mice...
  3. ncbi Mechanisms of action for an anti-radiation vaccine in reducing the biological impact of high dose and dose-rate, low-linear energy transfer radiation exposure
    V Maliev
    Vladicaucasian Scientific Center, Russian Academy of Sciences, Biotechnology Departament, Russia
    Radiats Biol Radioecol 47:286-91. 2007
    ....
  4. doi An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    Lyudmila G Burdelya
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Science 320:226-30. 2008
    ..CBLB502 also showed radioprotective activity in lethally irradiated rhesus monkeys. Thus, TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as biological protectants in radiation emergencies...
  5. ncbi Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation
    J H Hong
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Kwei Shan, Taoyuan, Taiwan
    Int J Radiat Biol 75:1421-7. 1999
    ..To investigate cytokine gene expression in the lung after single and fractionated doses of radiation, and to investigate the effect of steroids and the genetic background...
  6. ncbi Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time
    Samuel Ryu
    Department of Radiation Oncology and Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
    J Neurooncol 82:119-24. 2007
    ..This study was to determine the optimum dose and administration time of ramipril for mitigating radiation-induced optic neuropathy...
  7. ncbi The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model
    Ibrahim Kocer
    Department of Ophthalmology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey
    Graefes Arch Clin Exp Ophthalmol 245:588-94. 2007
    ..The objective was to determine the antioxidant role of L-carnitine (LC) against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats with a single dose of 5 Gy...
  8. ncbi Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat
    Jae Ho Kim
    Departments of Radiation Oncology, Neurosurgery and Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    Radiat Res 161:137-42. 2004
    ..The study represents the first demonstration of prophylaxis of radiation injury by a carboxyl-containing ACE inhibitor, providing a pharmacological strategy designed to reduce radiation-induced normal tissue damage...
  9. doi Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice
    Jian Zhang
    Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, East Road 305, 210002 Nanjing, People s Republic of China
    J Biomed Sci 15:585-94. 2008
    ..MSCs genetically modified by CXCR4 (the receptor for SDF-1) engrafted into irradiated intestine at a significantly elevated level and ameliorated the intestinal permeability and histopathological damage...
  10. ncbi Maximum tolerable dose for avoidance of cataract after repeated exposure to ultraviolet radiation in rats
    Xiuqin Dong
    St Erik s Eye Hospital, Karolinska Institutet, Polhemsgatan 50, S 112 82 Stockholm, and Orebro University Hospital, Sweden
    Exp Eye Res 84:200-8. 2007
    ..The accumulated threshold dose for damage after two repeated equivalent exposures to UVR-B increases as a function of inter-exposure interval up to at least 30 days inter-exposure interval...
  11. ncbi Radiation-induced acute intestinal inflammation differs following total-body versus abdominopelvic irradiation in the ferret
    S L Freeman
    Department of Physiology and Biophysics, University of Calgary, Alberta, Canada
    Int J Radiat Biol 77:389-95. 2001
    ..The studies were designed to investigate the differences in the intestinal inflammatory response following abdominopelvic or total-body irradiation in a ferret model...
  12. ncbi Radioprotective effect of local administration of lysine-vasopressin and triglycyl-lysine-vasopressin on the rectal mucosa in rats
    G Bjelkengren
    Department of Experimental Medicine, , Sweden
    Acta Oncol 34:487-92. 1995
    ..This dose level has in a previous study not given any significant effects on the systemic circulation. Lysine-vasopressin in Natrosol solution seems to be a suitable combination for further studies...
  13. ncbi Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
    ..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits...
  14. ncbi Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model
    Natalia I Ossetrova
    Uniformed Services University, Armed Forces Radiobiology Research Institute, Scientific Research Department, Bethesda, Maryland 20889 5603, USA
    Int J Radiat Biol 85:837-50. 2009
    ..The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system...
  15. ncbi Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice
    John P Chute
    Large Scale Biology Corporation, Vacaville, Calif, USA
    Exp Hematol 32:308-17. 2004
    ..High-dose ionizing radiation can cause lethal myeloablation in exposed individuals. We examined whether ex vivo culture could rescue hematopoietic stem cells with repopulating capacity following harvest from lethally irradiated animals...
  16. ncbi Radiation-induced kidney injury: a role for chronic oxidative stress?
    Mike E Robbins
    Free Radical and Radiation Biology Program, Department of Radiology, The University of Iowa, B 180 ML, Iowa City, IA 52242, USA
    Micron 33:133-41. 2002
    ..These data support the hypothesis that renal irradiation is associated with a chronic and persistent oxidative stress...
  17. ncbi Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey
    Roy M Vigneulle
    Department of Radiation Oncology, Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Dig Dis Sci 47:1480-91. 2002
    ..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate...
  18. ncbi Intestinal and colonic motor alterations associated with irradiation-induced diarrhoea in rats
    C Picard
    Institut de Protection et de Surete Nucleaire, Digestive Radiobiology Unit, Toulouse, France
    Neurogastroenterol Motil 13:19-26. 2001
    ..Myeloperoxidase activity in the jejunum and colon was also increased on this day only. It is concluded that irradiation-induced diarrhoea occurs contemporaneously with disruption of MMC in the small intestine...
  19. ncbi Podophyllum hexandrum (Himalayan mayapple) extract provides radioprotection by modulating the expression of proteins associated with apoptosis
    Raj Kumar
    Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brigadier S K Mazumdar Road, Delhi 110054, India
    Biotechnol Appl Biochem 42:81-92. 2005
    ..The present study thus clearly demonstrated that P. hexandrum extract provides protection from gamma-radiation by the modulation of expression of proteins associated with cell death...
  20. ncbi [The influence of exogenous melanin on the development of female Wistar rats' posterity of first generation exposed to low doses at different dose rates during embryogenesis]
    G F Palyga
    Radiats Biol Radioecol 44:677-80. 2004
    ..The melanin's effect is less expressed with the chronic irradiation...
  21. ncbi Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study
    G C Jagetia
    Department of Radiobiology, Kasturba Medical College Manipal, Karnataka 576104, India
    Phytomedicine 12:209-15. 2005
    ..The administration of 400 mg/kg MGN induced 50% mortality, therefore LD50 of the drug was considered to be 400 mg/kg...
  22. ncbi Triphala, an ayurvedic rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, Karnataka, India
    J Altern Complement Med 10:971-8. 2004
    ..Triphala was found to scavenge (.)OH, O(2) (.) 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS)(.+) and NO(.) radicals in a dose dependent manner...
  23. doi Medicine. Drug bestows radiation resistance on mice and monkeys
    Yudhijit Bhattacharjee
    Science 320:163. 2008
  24. ncbi Fruit extract of Aegle marmelos protects mice against radiation-induced lethality
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Integr Cancer Ther 3:323-32. 2004
    ....
  25. ncbi Modulation of rodent spinal cord radiation tolerance by administration of platelet-derived growth factor
    Nicolaus H Andratschke
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 60:1257-63. 2004
    ..To examine the role of platelet-derived growth factor (PDGF) for ameliorating radiation myelopathy of the cervical spinal cord in a rodent model...
  26. ncbi Polyherbal extract of septilin protects mice against whole body lethal dose of gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, India
    Phytother Res 18:619-23. 2004
    ..33%) which was used as a positive control. The LD(50) of Septilin was 1250 mg/kg as against the optimum protective dose of 100 mg/kg. Our study demonstrates Septilin as a good radioprotective agent...
  27. ncbi Radioprotective effects of amifostine (WR-2721) or cystamine on radiation damage and its repair in rats whole body exposed to fission neutrons
    Pavel Kuna
    Department of Radiology and Toxicology, Faculty of Health and Social Studies, University of South Bohemia, Ceske Budejovice, Czech Republic
    Acta Medica (Hradec Kralove) 47:19-23. 2004
    ..WR-2721 and cystamine i.m. were not able to increase 6 days reparation processes after sublethal 2 Gy fission neutrons whole body irradiated rats...
  28. ncbi Protective effect of an extract of Phyllanthus amarus against radiation-induced damage in mice
    K B Hari Kumar
    Amala Cancer Research Centre
    J Radiat Res 45:133-9. 2004
    ..amarus treatment, both in serum and liver. The results collectively indicate that P. amarus extract could increase the antioxidant defense mechanism in mice and there by protect the animals from radiation-induced cellular damage...
  29. ncbi [Time- and dose-dependent post-irradiation changes of Fe3+-transferrin and Cu2+-ceruloplasmin pools in blood, their influence on ribonucleotide reductase activity in animal tissues and the effects of radioprotectors]
    V L Sharygin
    Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia
    Radiats Biol Radioecol 43:662-77. 2003
    ..The key event ensuring the development of compensatory adaptive reactions is the increase of capacity of protein-synthesizing apparatus, the activation of biosynthesis of dNTP and DNA against the treatment with damaging factors...
  30. ncbi Modification of delayed radiation-induced reactions of duodenal vessels and mast cells in old rats
    V V Popuchiev
    Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk Institute of Industrial Organic Chemistry, Pschina, Poland
    Bull Exp Biol Med 136:399-403. 2003
    ..5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival...
  31. ncbi Protective effect of local temporary ischemia depends on applied dose of radiation
    Piotr Walichiewicz
    Department of Experimental and Clinical Radiobiology, Institute of Oncology, 44 101 Gliwice, Poland
    Cancer Lett 222:113-8. 2005
    ..Local temporary ischaemia provides general protection against radiation damage for lower dose. This protective effect disappeared after applications of a higher dose of radiation...
  32. ncbi Radioprotective effects of various cytokines in peripheral blood mononuclear cells and C3H mice
    Ju Young Kim
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Oncol Rep 13:1177-83. 2005
    ..These findings indicate that the combined treatment of IL-3 and SCF prevents the apoptosis induced in PBMCs by gamma-irradiation in vitro, but it does not afford any in vivo radioprotective effect in lethally irradiated C3H mice...
  33. ncbi Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice
    Vipan Kumar Parihar
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal 576104, India
    Mutat Res 611:9-16. 2006
    ..There was no protection at a dose less than 25mg/kg bw...
  34. ncbi Acceleration of normal-tissue damage expression by early stimulation of cell proliferation in rat spinal cord
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Strahlenther Onkol 182:680-4. 2006
    ..To examine experimental strategies for prevention of radiation-induced late spinal cord damage...
  35. ncbi Guanosine and inosine as natural antioxidants and radioprotectors for mice exposed to lethal doses of gamma-radiation
    S V Gudkov
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia
    Dokl Biochem Biophys 407:47-50. 2006
  36. ncbi Evaluation of the radioprotective effect of Liv 52 in mice
    Ganesh C Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India
    Environ Mol Mutagen 47:490-502. 2006
    ....
  37. ncbi Radiation-induced production of PAR-1 and TGF-beta 1 mRNA in lung of C57Bl6 and C3H murine strains and influence of pharmacoprophylaxis by ACE inhibitors
    Radoslav Matej
    Department of Pathology, Thomayer Teaching Hospital, Videnska 800, Prague 4 Krc, 14059 Prague, Czech Republic
    Pathol Res Pract 203:107-14. 2007
    ..Thus, PAR-1 is involved in radiation-induced lung fibrosis in correlation with TGF-beta1 production. Administration of ACEI influences PAR-1 and TGF-beta1 expression...
  38. ncbi Radioprotection of Swiss albino mice by Myristica fragrans houtt
    Mini Sharma
    Cell and Molecular Biology Lab, Department of Zoology, University of Rajasthan, Jaipur, India
    J Radiat Res (Tokyo) 48:135-41. 2007
    ..The present study has implications for the potential use of MF as a radioprotector...
  39. ncbi Is growth hormone a radioprotective agent?
    S B Tekin
    Department of Medical Oncology, University Faculty of Medicine, Erzurum, Turkey
    J Eur Acad Dermatol Venereol 20:293-8. 2006
    ..These results are preliminary to studies that will be performed with higher doses of GH in radiation-treated cancer patients, with the aim of reducing radiation-induced toxicity...
  40. ncbi Effects of Aegle marmelos (L.) Correa on the peripheral blood and small intestine of mice exposed to gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    J Environ Pathol Toxicol Oncol 25:611-24. 2006
    ..The data clearly indicate that the AME significantly reduced the deleterious effect of radiation in the intestine and bone marrow of mouse and could be a useful agent in reducing the side effects of therapeutic radiation...
  41. ncbi Radioprotective potential of Rosemarinus officinalis against lethal effects of gamma radiation : a preliminary study
    Archana Jindal
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    J Environ Pathol Toxicol Oncol 25:633-42. 2006
    ..The present study demonstrates that Rosemarinus officinalis leave extract is a good radioprotector...
  42. ncbi Morphological changes of rat jejunum after whole body gamma-irradiation and their impact in biodosimetry
    D Driak
    Gynaecological Obstetric Clinic, University Hospital Bulovka, Prague, Czech Republic
    Physiol Res 57:475-9. 2008
    ..This is in accordance with tasks and Standardization Agreement of the North Atlantic Treaty Organization...
  43. ncbi Prophylactic effect of flaxseed oil against radiation-induced hepatotoxicity in mice
    A L Bhatia
    Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 21:852-9. 2007
    ..The study does not rule out the possibility of a prophylactic potential of flaxseed oil against radiation-induced degenerative changes in liver...
  44. ncbi Evaluation of insulin-like growth factor-1 for prevention of radiation-induced spinal cord damage
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Growth Factors 23:15-8. 2005
    ....
  45. ncbi Studies on the protective effects of Boerhaavia diffusa L. against gamma radiation induced damage in mice
    K A Manu
    Amala Cancer Research Centre, Amala Nagar, Kerala State, India
    Integr Cancer Ther 6:381-8. 2007
    ..diffusa. These results are indicative of the radioprotective effect of the whole-plant extract of B. diffusa...
  46. ncbi Modulatory influence of Adhatoda vasica Nees leaf extract against gamma irradiation in Swiss albino mice
    A Kumar
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    Phytomedicine 12:285-93. 2005
    ..A significant increase in the serum alkaline phosphatase activity and decrease in acid phosphatase activity was observed in A. vasica leaf extract pretreated irradiated animals during the entire period of study...
  47. ncbi Immunomodulatory and cytoprotective role of RP-1 in gamma-irradiated mice
    H C Goel
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Timarpur, Delhi, India
    Mol Cell Biochem 254:73-81. 2003
    ..05) reduced (1.23%) the radiation-induced MN frequency (2.9%) observed at 48 h post-irradiation interval. Since the radioprotective manifestation of RP-1 is mediated through multiple mechanisms, needs further investigation...
  48. ncbi [Dependence of the therapeutic effectiveness of interleukin-1beta on the time of the drug administration after irradiation of mice]
    L M Rozhdestvenskiĭ
    State Research Centre of Russia Institute of Biophysics, Moscow, 123182 Russia
    Radiats Biol Radioecol 42:65-9. 2002
    ..There were analyzed the reasons of weaker betaleukin effect and shorter period of its effectiveness after exposure in comparison with literature data regarding IL-1...
  49. doi Elaeocarpus sylvestris modulates gamma-ray-induced immunosuppression in mice: implications in radioprotection
    Eunjin Park
    Department of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju 690 756, South of Korea
    Phytother Res 22:1046-51. 2008
    ..Therefore, it is concluded that the E.S. extract may be an effective agent of protection from radiation-induced injuries...
  50. pmc Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene
    Xichen Zhang
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Hum Gene Ther 19:820-6. 2008
    ..Intravenous, systemic administration of mc-MnSOD-PL protected mice from total body irradiation (9.75 Gy). Therefore, minicircle DNA containing the human MnSOD transgene confers undiminished radioprotection in vitro and in vivo...
  51. ncbi Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival
    Francis Herodin
    Centre de Recherches du Service de Sante des Armees, Departement of Radiobiology, Radiohematology Unit 24, La Tronche, France
    Blood 101:2609-16. 2003
    ..The proposal is made that an emergency cytokine regimen could be applied to nuclear accident victims as part of longer cytokine treatment, cell therapy, or both...
  52. doi Harnessing the power of bacteria to protect the gut
    Maria T Abreu
    N Engl J Med 359:756-9. 2008
  53. ncbi [Effect of mexidol on hemopoietic system in conditions of an emotional stress after exposure to ionizing radiation]
    B B Moroz
    Radiats Biol Radioecol 47:163-70. 2007
    ..The pharmacological correction by mexidol from displays of an intensive emotional stress, developing after an irradiation in various doses, can be a part in system of medical measures...
  54. ncbi Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?
    S A Lorimore
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Oncogene 20:7085-95. 2001
    ....
  55. ncbi Modification of radiation response in mice by Panax ginseng and diethyldithiocarbamate
    S H Kim
    Department of Anatomy, College of Veterinary Medicine, Chonnam National University, 300 Yongbong-dong, Puk-ku, Kwangju 500-757, South Korea
    In Vivo 15:407-11. 2001
    ..Further studies are needed to fully characterize the protective nature of ginseng extract and its components...
  56. ncbi Redox metal chelation ameliorates radiation-induced bone marrow toxicity in a mouse model
    R M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
    Radiat Res 156:205-9. 2001
    ..We suggest that radiation-induced toxicity is caused by the deleterious effect of redox-active metal ions, and that compounds which modulate this redox activity may act as radioprotectors...
  57. ncbi Radioprotection by copper and zinc complexes of 5-aminosalicylic acid: a preliminary study
    S K Mantena
    Department of Pharmacology, College of Pharmaceutical Sciences, Manipal 576 119, India
    J Environ Pathol Toxicol Oncol 27:123-34. 2008
    ..The data clearly indicate that both Cu-5ASA and Zn-5ASA significantly reduced the deleterious effect of radiation and hence could be useful agents in reducing the side effects of therapeutic radiation...
  58. ncbi Induction of apoptosis in bone marrow cells after treatment of mice with WR-2721 and gamma-rays: relationship to the cell cycle
    L Mazur
    Laboratory of Experimental Hematology and Toxicology, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Cracow, Poland
    Cell Biol Toxicol 19:13-27. 2003
    ..A modulatory, suppressive action of WR-2721 on apoptosis induction and the cell cycle perturbation caused in normal cells of the mouse bone marrow by gamma-rays was found...
  59. ncbi Amelioration of radiation-induced oxidative stress and biochemical alteration by SOD model compounds in pre-treated gamma-irradiated rats
    Mosaad A M Abou-Seif
    Chemistry Department, Faculty of Science, Mansoura University, El Mansura, Egypt
    Clin Chim Acta 337:23-33. 2003
    ....
  60. doi Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats
    Kannampalli Pradeep
    Radiation Research Division for Biotechnology, Korea Atomic Energy Research Institute, 1266 Shinjeong dong, Jeongeup, Jeonbuk 580 185, Republic of Korea
    Eur J Pharmacol 587:273-80. 2008
    ....
  61. ncbi [Copper content in the blood of irradiated animals]
    L H Petryna
    Ivano Frankivsk Medical Academy
    Fiziol Zh 49:97-104. 2003
    ..5, 1, 2, 4, 6, 8, 10, 15, 20, 35, 45, 60, 90 and 120 days after exposing to irradiation. Maximal rate of changes in the content of copper in the blood of rats took place in 2-8 days after irradiation and were dose-dependent...
  62. ncbi Radiomodulatory influence of Rajgira (Amaranthus paniculatus) leaf extract in Swiss albino mice
    J Maharwal
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, India
    Phytother Res 17:1150-4. 2003
    ..The results from the present study suggest that Rajgira pretreatment provide protection against gamma irradiation in mice...
  63. ncbi Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 119, India
    Radiat Res 160:584-92. 2003
    ..ZOE also had a dose-dependent antimicrobial activity against Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli and Candida albicans...
  64. ncbi Mentha piperita (Linn) leaf extract provides protection against radiation induced alterations in intestinal mucosa of Swiss albino mice
    R M Samarth
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Indian J Exp Biol 40:1245-9. 2002
    ..The results suggest that Mentha pretreatment provides protection against radiation induced alterations in intestinal mucosa of Swiss albino mice...
  65. ncbi Evaluation of the radioprotective effect of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 119, India
    J Pharm Pharmacol 55:1151-8. 2003
    ..ACE was found to scavenge DPPH radicals in a concentration-dependent manner, indicating that the radioprotection afforded by ACE may be in part due to the scavenging of reactive oxygen species induced by ionizing radiation...
  66. ncbi [Reactions of deoxyribonucleotide synthesis system to irradiation and their modification by radioprotectors]
    M K Pulatova
    Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia
    Radiats Biol Radioecol 43:29-43. 2003
    ..In vivo regulatory factors of dNTP synthesis have been studied to elucidate the mechanisms of getting of high and balanced dNTP pools by using of different substances...
  67. ncbi Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of gamma-irradiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 119, Kamataka, India
    Nahrung 47:181-5. 2003
    ..wt. of SCE. However, the best protection was obtained for 30 mg/kg b.wt. SCE, where the number of, survivors after 30 days post-irradiation was highest (41.66%) when compared with the other doses of SCE...
  68. ncbi Alteration in the glutathione, glutathione peroxidase, superoxide dismutase and lipid peroxidation by ascorbic acid in the skin of mice exposed to fractionated gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 119, India
    Clin Chim Acta 332:111-21. 2003
    ....
  69. ncbi Time course of neurotrophic factor upregulation and retinal protection against light-induced damage after optic nerve section
    Krisztina Valter
    CNS Stability and Degeneration Group, Research School of Biological Sciences, The Australian National University, Canberra City, Canberra, ACT 2601, Australia
    Invest Ophthalmol Vis Sci 46:1748-54. 2005
    ..To assess neurotrophic factor upregulation in the retina after damage to the optic nerve and relate that regulation to changes in photoreceptor stability and function...
  70. ncbi [Experimental studies of the relative biological effectiveness of accelerated charged particles varying in energy]
    B S Fedorenko
    Aviakosm Ekolog Med 40:55-63. 2006
    ..Consideration is given to factors that may modify RBE values estimated for different types of radiation...
  71. doi Multipotent mesenchymal stem cell grafting to treat cutaneous radiation syndrome: development of a new minipig model
    Diane Agay
    IRBA antenne La Tronche CRSSA, La Tronche, France
    Exp Hematol 38:945-56. 2010
    ..Here, we have developed a new minipig model of severe CRS to study underlying mechanisms of this cell therapy approach...
  72. doi Dose-response effect of charged carbon beam on normal rat retina assessed by electroretinography
    Atsushi Mizota
    Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 78:1532-40. 2010
    ..To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats...
  73. doi Photochemical internalization of bleomycin before external-beam radiotherapy improves locoregional control in a human sarcoma model
    Ole Jacob Norum
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Radiat Oncol Biol Phys 75:878-85. 2009
    ..Photochemical internalization is a technology to improve the utilization of therapeutic macromolecules in cancer therapy by photochemical release of endocytosed macromolecules into the cytosol...
  74. doi Effect of 5-S-GAD on UV-B-induced cataracts in rats
    Hiroyoshi Kawada
    Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan
    Jpn J Ophthalmol 53:531-5. 2009
    ..This is a report of an investigation of the effect of 5-S-GAD (eyedrops) on UVB-induced cataracts in rats...
  75. doi Effect of intermittent light on photoreceptor cells in the rabbit retina
    Arash Esfandiari
    Department of Anatomical Sciences, School of Veterinary Medicine, Islamic Azad University, Kazerun Branch, Kazerun, Iran
    Jpn J Ophthalmol 53:635-9. 2009
    ..The objective of the present study was to determine what histological changes occur in the photoreceptor layer of male rabbits exposed to intermittent light of different intensities...
  76. pmc Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus
    Kenneth A Jenrow
    Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Radiat Oncol 5:6. 2010
    ..Here we investigate the angiotensin converting enzyme (ACE) inhibitor, ramipril, as a mitigator of radiation injury in this context...
  77. ncbi [Expression of aquaporin-4 protein in rats with acute radiation-induced cerebral edema]
    Jiao de Jiang
    Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:252-6. 2008
    ..To explore the relation between changes in expression of aquaporin-4(AQP4) protein and acute radiation-induced cerebral edema after Gamma knife radiation...
  78. pmc Biodistributions, myelosuppression, and toxicities in mice treated with an anti-CD45 antibody labeled with the alpha-emitting radionuclides bismuth-213 or astatine-211
    Hirohisa Nakamae
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Cancer Res 69:2408-15. 2009
    ..The data suggest that smaller quantities of (211)At-labeled anti-CD45 antibody are sufficient to achieve myelosuppression and myeloablation with less nonhematologic toxicity compared with (213)Bi-labeled antibody...
  79. ncbi 900 MHz radiofrequency-induced histopathologic changes and oxidative stress in rat endometrium: protection by vitamins E and C
    Mehmet Guney
    Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    Toxicol Ind Health 23:411-20. 2007
    ....
  80. doi Therapeutic potential of non-adherent BM-derived mesenchymal stem cells in tissue regeneration
    Z L Zhang
    Calcium Research Laboratory, McGill University Health Centre and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Bone Marrow Transplant 43:69-81. 2009
    ..In an appropriate microenvironment, they can adhere, proliferate and differentiate into specialized cells of target tissues and thus function in damaged tissue regeneration and repair...
  81. doi Bone marrow sinusoidal endothelial cells undergo nonapoptotic cell death and are replaced by proliferating sinusoidal cells in situ to maintain the vascular niche following lethal irradiation
    Xiao Miao Li
    Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Exp Hematol 36:1143-1156. 2008
    ..Bone marrow sinusoids remain predominantly host-derived following bone marrow transplantation. Systematic analysis was conducted at the cellular level to investigate how the host sinusoidal structures survived after lethal irradiation...
  82. ncbi [Effects of blood-cooling and promoting drugs on rats with radiation-induced lung injury]
    Ming Hui Yanf
    Department of Traditional Chinese Medicine, General Hospital of PLA, Beijing
    Zhongguo Zhong Xi Yi Jie He Za Zhi 27:827-31. 2007
    ....
  83. doi Eye damage control by reduced blue illumination
    Toshihiko Ueda
    Department of Ophthalmology, School of Medicine, Showa University, 1 5 8, Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Exp Eye Res 89:863-8. 2009
    ..This experimental system is a useful model for normal human eye aging and continuous spectrum environment irradiance...
  84. ncbi Injured microenvironment directly guides the differentiation of engrafted Flk-1(+) mesenchymal stem cell in lung
    Xi Yan
    Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Center of Excellence in Tissue Engineering, Beijing, China
    Exp Hematol 35:1466-75. 2007
    ..This study was aimed to analyze the engraftment and differentiation behavior of MSC transplanted at different time points after lung irradiation, and the possible mechanisms were discussed...
  85. pmc The radioprotective effects of the hexane and ethyl acetate extracts of Callophyllis japonica in mice that undergo whole body irradiation
    Jeongtae Kim
    College of Veterinary Medicine, and the Research Institute for Subtropical Agriculture and Biotechnology, Cheju National University, Jeju 690 756, Korea
    J Vet Sci 9:281-4. 2008
    ....
  86. ncbi Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
    Biol Pharm Bull 30:946-51. 2007
    ..Treatment with test components after lethal irradiation was ineffective. These results suggest that propolis and its polyphenolic compounds given to mice before irradiation protect mice from the lethal effects of whole-body irradiation...
  87. doi Changes in myelin basic protein and demyelination in the rat brain within 3 months of single 2-, 10-, or 30-Gy whole-brain radiation treatments
    Ye Tian
    Department of Radiotherapy and Oncology, Second Affiliated Hospital, Suzhou University, Jiangsu, People s Republic of China
    J Neurosurg 109:881-8. 2008
    ....
  88. ncbi Role of connective tissue growth factor in experimental radiation nephropathy in rats
    Dian ge Liu
    Department of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China
    Chin Med J (Engl) 121:1925-31. 2008
    ..We investigated the role of CTGF on the progression of a rat model of radiation nephropathy...
  89. pmc Microarray analysis of irradiated growth plate zones following laser microdissection shows later importance of differentially expressed genes during radiorecovery
    Meredith R Pritchard
    Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY 13057, USA
    Cells Tissues Organs 192:240-9. 2010
    ..Potential targets for selective radiorecovery modulation were investigated via the identification of late upregulated genes and pathways during growth plate chondrocyte recovery...
  90. pmc Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice
    Wouter Schul
    MGC, Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 21:4719-29. 2002
    ..Thus, providing mice with CPD photolyase significantly improves repair and uncovers the biological effects of CPD lesions...
  91. ncbi Modification of gamma ray induced changes in the mouse hepatocytes by Centella asiatica extract: in vivo studies
    Radha Sharma
    Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 19:605-11. 2005
    ..The number of binucleated cells and abnormal hepatocytes was less in comparison with the animals irradiated without Centella asiatica pretreatment...
  92. ncbi Effect of age on radiation-induced early changes of rat rectum. A histological time sequence
    M J Olofsen-van Acht
    Department of Radiation Oncology, University Hospital Rotterdam - Daniel den Hoed Cancer Center/Dijkzigt Hospital, Groene Hilledijk 301, 3075 EA, The, Rotterdam, Netherlands
    Radiother Oncol 59:71-9. 2001
    ..Although the survival of these Wistar rats in earlier studies was not affected by age, the impact of the observed histological differences for their importance in the long-term is currently being investigated...
  93. ncbi Irradiation-induced oral candidiasis in an experimental murine model
    C S Farah
    Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, Queensland 4072, Australia
    Oral Microbiol Immunol 16:358-63. 2001
    ..The results of this study demonstrate a requirement for CD4+ T cells in the recovery from oral candidiasis induced by head and neck irradiation in mice, and are consistent with a role for Th1-type cytokines in host resistance...
  94. ncbi The protective effect of alpha-lipoic acid against oxidative damage in rabbit conjunctiva and cornea exposed to ultraviolet radiation
    Ulku Demir
    Department of Ophthalmology, Medical Faculty, Firat University, Elazig, Turkey
    Ophthalmologica 219:49-53. 2005
    ..The purpose of this study was to determine the protective effect of alpha-lipoic acid against oxidative damage in rabbit conjunctiva and cornea exposed to ultraviolet radiation...
  95. ncbi Protective role of corneal epithelium against ultraviolet radiation damage
    Alexander Podskochy
    Department of Ophthalmology, Linkoping University Hospital, Linkoping, Sweden
    Acta Ophthalmol Scand 82:714-7. 2004
    ..The aim of the present study was to examine the protective role of corneal epithelium against UVR damage by comparing the biological effect of UVR exposure on whole corneas with that on de-epithelialized corneas...
  96. ncbi Prophylactic effects of magnesium and vitamin E in rat spinal cord radiation damage: evaluation based on lipid peroxidation levels
    Selcuk Peker
    Department of Neurosurgery, Marmara University School of Medicine, Istanbul 34662, Turkey
    Life Sci 75:1523-30. 2004
    ..001). The results indicate that i.p. magnesium sulfate has a marked neuroprotective effect against radiation-induced oxidative stress in the rat spinal cord...
  97. ncbi A photothrombotic model of small early ischemic infarcts in the rat brain with histologic and MRI correlation
    P H Pevsner
    Department of Pharmacology, New York University School of Medicine, NYU Medical Center, 550 First Ave, New York, New York 10016, USA
    J Pharmacol Toxicol Methods 45:227-33. 2001
    ..As demonstrated by a comparison with the histologic features of such infarcts in surgical and autopsy brain specimens, the model is relevant to acute human ischemic infarcts...
  98. ncbi Effects of the nerve growth factor on the survival and wound healing in mice with combined radiation and wound injury
    Chun Meng Shi
    Institute of Combine Injury, School of Preventive Medicine, Third Military Medical University, China
    J Radiat Res 44:223-8. 2003
    ..These results showed evidence that NGF could increase wound healing and promote survival in irradiated animals. This dual effect of NGF may provide a new tool for the treatment of radiation-combined injuries...
  99. ncbi Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers
    John P Chute
    Navy National Institute of Diabetes and Digestive and Kidney Diseases Transplantation and Autoimmunity Branch, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Mil Med 167:74-7. 2002
    ..1%; mean, 1.9%). These results demonstrate that a subpopulation of bone marrow stem cells are capable of surviving the effects of high-dose radiation if these cells are placed in coculture with endothelial cell monolayers...
  100. ncbi Radioprotective effect of silymarin against radiation induced hepatotoxicity
    Laila A Ramadan
    Department of Drug Radiation Research and Radiation Biology, National Centre For Radiation Research And Technology NCRRT, Atomic Energy Authority, PO Box 29, Nasr City, Cairo, Egypt
    Pharmacol Res 45:447-54. 2002
    ..v.) injection (50 mg kg (-1)), caused significant protection. Intravenous treatment showed the most pronounced protection. The protective effect of silymarin was attributed to its antioxidant and free radicals scavenging properties...
  101. ncbi Enhancement of antiradiation potential of some aminothiols by beta-carotene
    Hussain K Al-Wandawi
    Division of Environmental Researches and Workers Protection, Iraqi Atomic Energy Commission, Baghdad, Iraq
    Ann Nutr Metab 47:176-80. 2003
    ..On the other hand, the response of male and female mice 10 days after exposure to the above radiation dose indicated that the females were more radioresistant than the males...

Research Grants133 found, 100 shown here

  1. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 1980
    ..A comparison of retinal pigment epithelium cell plasma membrane proteins and lipid composition and their interactions in intact isolated pigment epithelial cells will also be assessed in normal and mutant rats...
  2. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 1993
    ....
  3. Radiation-Induced Heart Disease: Mechanisms and Interventions
    Marjan Boerma; Fiscal Year: 2010
    ....
  4. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 2003
    ..In addition, the time course of the appearance of cytoplasmic cytochrome C and the activation of cellular caspases will be determined by antibody-based techniques, immunocytochemistry and enzymatic analysis. ..
  5. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2007
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  6. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2007
    ..abstract_text> ..
  7. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2006
    ..4) Complete the randomized, prospective, trial of the use of ACE inhibitors to prevent the development of radiation nephropathy in BMT patients. ..
  8. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2003
    ..abstract_text> ..
  9. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2001
    ..7) To determine the conditions under which pulsed low dose rate (LDR) and continuous LDR produce clinically equivalent normal tissue injury. ..
  10. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 1999
    ..5. Study the prevention of such glycation by these compounds in vivo in diabetic and galactosemic animals. ..
  11. KIDNEY RESPONSE TO FRACTIONED RADIATION
    JOHN MOULDER; Fiscal Year: 1980
    ..Some of the animals surviving the first course of treatment will be given a second fractionated treatment 6 to 18 months later...
  12. OXIDATIVE STRESS ON THE OCULAR LENS
    SHAMBHU VARMA; Fiscal Year: 1993
    ..The monkey's aqueous humor will be analyzed for ascorbate and amino acid contents as a function of age...
  13. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2005
    ..Hypothesis #5 will be verified by the relative activity of the keto acids in scavenging ROS, and their effectiveness in preventing lens damage in culture, as indexed by the cation pump activity, and the above biochemical parameters. ..
  14. OXIDATIVE STRESS AND CATARACT FORMATION
    Shambhu D Varma; Fiscal Year: 2010
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  15. Mechanisms of IGF-1 mediated rescue of radiation-induced salivary gland dysfuncti
    Kirsten H Limesand; Fiscal Year: 2010
    ..The studies could have the potential to prevent or restore salivary gland function to head and neck cancer patients. ..
  16. PATTERNING GENES IN RETINAL DEVELOPMENT
    Deborah L Stenkamp; Fiscal Year: 2010
    ..Our findings will have applications for the development of photoreceptor replacement strategies and photoreceptor survival therapies, as well as for the prevention and treatment of developmental abnormalities of the retina. ..
  17. Brain Irradiation Affects Neuronal Function
    Susanna Rosi; Fiscal Year: 2010
    ..These types of data are currently unavailable and are essential for determining the risks of specific central nervous system related effects and for the development of potential strategies to manage radiation-mediated brain injury. ..
  18. PATTERNING GENES IN RETINAL DEVELOPMENT
    DEBORAH STENKAMP; Fiscal Year: 2007
    ..An improved understanding of the mechanisms of action of Hh and RA will be valuable for reassessing current treatments, and for designing future therapies. ..
  19. Salivary Acinar Cell Apoptosis: Regulation of p53 by Akt
    KIRSTEN LIMESAND; Fiscal Year: 2007
    ..New understanding of the fundamental biological process of p53 regulation could have a powerful impact on clinical therapeutics for salivary glands. ..
  20. Study of the RPE barrier
    Yun Zheng Le; Fiscal Year: 2010
    ..Our study will focus on the regulatory mechanism and the pathophysiology of blood-retina barriers. ..
  21. STRUCTURAL BASES FOR OPTICAL PROPERTIES OF CORNEAS
    RUSSELL MCCALLY; Fiscal Year: 2004
    ..For the rabbit study, resolution and F.A.C.T. charts will be imaged through freshly excised corneas and the potential degradation in visual performance will be correlated with scatterometer measurements. ..