experimental radiation injuries

Summary

Summary: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.

Top Publications

  1. ncbi Radioprotection of Swiss albino mouse by Centella asiatica extract
    Jaimala Sharma
    Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 16:785-6. 2002
  2. ncbi Protection of Swiss albino mice against whole-body gamma irradiation by diltiazem
    V Nunia
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    Br J Radiol 80:77-84. 2007
  3. ncbi Mechanisms of action for an anti-radiation vaccine in reducing the biological impact of high dose and dose-rate, low-linear energy transfer radiation exposure
    V Maliev
    Vladicaucasian Scientific Center, Russian Academy of Sciences, Biotechnology Departament, Russia
    Radiats Biol Radioecol 47:286-91. 2007
  4. ncbi An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    Lyudmila G Burdelya
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Science 320:226-30. 2008
  5. ncbi Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
  6. ncbi Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice
    John P Chute
    Large Scale Biology Corporation, Vacaville, Calif, USA
    Exp Hematol 32:308-17. 2004
  7. ncbi Maximum tolerable dose for avoidance of cataract after repeated exposure to ultraviolet radiation in rats
    Xiuqin Dong
    St Erik s Eye Hospital, Karolinska Institutet, Polhemsgatan 50, S 112 82 Stockholm, and Orebro University Hospital, Sweden
    Exp Eye Res 84:200-8. 2007
  8. ncbi Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation
    J H Hong
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Kwei Shan, Taoyuan, Taiwan
    Int J Radiat Biol 75:1421-7. 1999
  9. ncbi Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time
    Samuel Ryu
    Department of Radiation Oncology and Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
    J Neurooncol 82:119-24. 2007
  10. ncbi Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat
    Jae Ho Kim
    Departments of Radiation Oncology, Neurosurgery and Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    Radiat Res 161:137-42. 2004

Research Grants

Detail Information

Publications214 found, 100 shown here

  1. ncbi Radioprotection of Swiss albino mouse by Centella asiatica extract
    Jaimala Sharma
    Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 16:785-6. 2002
    ..Body weight loss of the animals in the drug treated group was significantly less in comparison with the animals that were given radiation only. The causes and mechanism of protection and other aspects need further investigations...
  2. ncbi Protection of Swiss albino mice against whole-body gamma irradiation by diltiazem
    V Nunia
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    Br J Radiol 80:77-84. 2007
    ..From our study it is clear that DTZ provides protection against radiation-induced haematological and biochemical alterations in Swiss albino mice...
  3. ncbi Mechanisms of action for an anti-radiation vaccine in reducing the biological impact of high dose and dose-rate, low-linear energy transfer radiation exposure
    V Maliev
    Vladicaucasian Scientific Center, Russian Academy of Sciences, Biotechnology Departament, Russia
    Radiats Biol Radioecol 47:286-91. 2007
    ....
  4. ncbi An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    Lyudmila G Burdelya
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Science 320:226-30. 2008
    ..CBLB502 also showed radioprotective activity in lethally irradiated rhesus monkeys. Thus, TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as biological protectants in radiation emergencies...
  5. ncbi Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
    ..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits...
  6. ncbi Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice
    John P Chute
    Large Scale Biology Corporation, Vacaville, Calif, USA
    Exp Hematol 32:308-17. 2004
    ..High-dose ionizing radiation can cause lethal myeloablation in exposed individuals. We examined whether ex vivo culture could rescue hematopoietic stem cells with repopulating capacity following harvest from lethally irradiated animals...
  7. ncbi Maximum tolerable dose for avoidance of cataract after repeated exposure to ultraviolet radiation in rats
    Xiuqin Dong
    St Erik s Eye Hospital, Karolinska Institutet, Polhemsgatan 50, S 112 82 Stockholm, and Orebro University Hospital, Sweden
    Exp Eye Res 84:200-8. 2007
    ..The accumulated threshold dose for damage after two repeated equivalent exposures to UVR-B increases as a function of inter-exposure interval up to at least 30 days inter-exposure interval...
  8. ncbi Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation
    J H Hong
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Kwei Shan, Taoyuan, Taiwan
    Int J Radiat Biol 75:1421-7. 1999
    ..To investigate cytokine gene expression in the lung after single and fractionated doses of radiation, and to investigate the effect of steroids and the genetic background...
  9. ncbi Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time
    Samuel Ryu
    Department of Radiation Oncology and Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
    J Neurooncol 82:119-24. 2007
    ..This study was to determine the optimum dose and administration time of ramipril for mitigating radiation-induced optic neuropathy...
  10. ncbi Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat
    Jae Ho Kim
    Departments of Radiation Oncology, Neurosurgery and Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    Radiat Res 161:137-42. 2004
    ..The study represents the first demonstration of prophylaxis of radiation injury by a carboxyl-containing ACE inhibitor, providing a pharmacological strategy designed to reduce radiation-induced normal tissue damage...
  11. ncbi Radiation-induced acute intestinal inflammation differs following total-body versus abdominopelvic irradiation in the ferret
    S L Freeman
    Department of Physiology and Biophysics, University of Calgary, Alberta, Canada
    Int J Radiat Biol 77:389-95. 2001
    ..The studies were designed to investigate the differences in the intestinal inflammatory response following abdominopelvic or total-body irradiation in a ferret model...
  12. ncbi The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model
    Ibrahim Kocer
    Department of Ophthalmology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey
    Graefes Arch Clin Exp Ophthalmol 245:588-94. 2007
    ..The objective was to determine the antioxidant role of L-carnitine (LC) against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats with a single dose of 5 Gy...
  13. ncbi Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice
    Jian Zhang
    Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, East Road 305, 210002 Nanjing, People s Republic of China
    J Biomed Sci 15:585-94. 2008
    ..MSCs genetically modified by CXCR4 (the receptor for SDF-1) engrafted into irradiated intestine at a significantly elevated level and ameliorated the intestinal permeability and histopathological damage...
  14. ncbi Radioprotective effect of local administration of lysine-vasopressin and triglycyl-lysine-vasopressin on the rectal mucosa in rats
    G Bjelkengren
    Department of Experimental Medicine, , Sweden
    Acta Oncol 34:487-92. 1995
    ..This dose level has in a previous study not given any significant effects on the systemic circulation. Lysine-vasopressin in Natrosol solution seems to be a suitable combination for further studies...
  15. ncbi Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model
    Natalia I Ossetrova
    Uniformed Services University, Armed Forces Radiobiology Research Institute, Scientific Research Department, Bethesda, Maryland 20889 5603, USA
    Int J Radiat Biol 85:837-50. 2009
    ..The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system...
  16. ncbi Radiation-induced kidney injury: a role for chronic oxidative stress?
    Mike E Robbins
    Free Radical and Radiation Biology Program, Department of Radiology, The University of Iowa, B 180 ML, Iowa City, IA 52242, USA
    Micron 33:133-41. 2002
    ..These data support the hypothesis that renal irradiation is associated with a chronic and persistent oxidative stress...
  17. ncbi Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey
    Roy M Vigneulle
    Department of Radiation Oncology, Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Dig Dis Sci 47:1480-91. 2002
    ..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate...
  18. ncbi Intestinal and colonic motor alterations associated with irradiation-induced diarrhoea in rats
    C Picard
    Institut de Protection et de Surete Nucleaire, Digestive Radiobiology Unit, Toulouse, France
    Neurogastroenterol Motil 13:19-26. 2001
    ..Myeloperoxidase activity in the jejunum and colon was also increased on this day only. It is concluded that irradiation-induced diarrhoea occurs contemporaneously with disruption of MMC in the small intestine...
  19. ncbi Protective effect of local temporary ischemia depends on applied dose of radiation
    Piotr Walichiewicz
    Department of Experimental and Clinical Radiobiology, Institute of Oncology, 44 101 Gliwice, Poland
    Cancer Lett 222:113-8. 2005
    ..Local temporary ischaemia provides general protection against radiation damage for lower dose. This protective effect disappeared after applications of a higher dose of radiation...
  20. doi Harnessing the power of bacteria to protect the gut
    Maria T Abreu
    N Engl J Med 359:756-9. 2008
  21. ncbi Induction of apoptosis in bone marrow cells after treatment of mice with WR-2721 and gamma-rays: relationship to the cell cycle
    L Mazur
    Laboratory of Experimental Hematology and Toxicology, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Cracow, Poland
    Cell Biol Toxicol 19:13-27. 2003
    ..A modulatory, suppressive action of WR-2721 on apoptosis induction and the cell cycle perturbation caused in normal cells of the mouse bone marrow by gamma-rays was found...
  22. ncbi Podophyllum hexandrum (Himalayan mayapple) extract provides radioprotection by modulating the expression of proteins associated with apoptosis
    Raj Kumar
    Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brigadier S K Mazumdar Road, Delhi 110054, India
    Biotechnol Appl Biochem 42:81-92. 2005
    ..The present study thus clearly demonstrated that P. hexandrum extract provides protection from gamma-radiation by the modulation of expression of proteins associated with cell death...
  23. ncbi Radioprotection by copper and zinc complexes of 5-aminosalicylic acid: a preliminary study
    S K Mantena
    Department of Pharmacology, College of Pharmaceutical Sciences, Manipal 576 119, India
    J Environ Pathol Toxicol Oncol 27:123-34. 2008
    ..The data clearly indicate that both Cu-5ASA and Zn-5ASA significantly reduced the deleterious effect of radiation and hence could be useful agents in reducing the side effects of therapeutic radiation...
  24. ncbi Triphala, an ayurvedic rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, Karnataka, India
    J Altern Complement Med 10:971-8. 2004
    ..Triphala was found to scavenge (.)OH, O(2) (.) 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS)(.+) and NO(.) radicals in a dose dependent manner...
  25. ncbi [The influence of exogenous melanin on the development of female Wistar rats' posterity of first generation exposed to low doses at different dose rates during embryogenesis]
    G F Palyga
    Radiats Biol Radioecol 44:677-80. 2004
    ..The melanin's effect is less expressed with the chronic irradiation...
  26. ncbi Modulation of rodent spinal cord radiation tolerance by administration of platelet-derived growth factor
    Nicolaus H Andratschke
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 60:1257-63. 2004
    ..To examine the role of platelet-derived growth factor (PDGF) for ameliorating radiation myelopathy of the cervical spinal cord in a rodent model...
  27. ncbi Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study
    G C Jagetia
    Department of Radiobiology, Kasturba Medical College Manipal, Karnataka 576104, India
    Phytomedicine 12:209-15. 2005
    ..The administration of 400 mg/kg MGN induced 50% mortality, therefore LD50 of the drug was considered to be 400 mg/kg...
  28. ncbi Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival
    Francis Herodin
    Centre de Recherches du Service de Sante des Armees, Departement of Radiobiology, Radiohematology Unit 24, La Tronche, France
    Blood 101:2609-16. 2003
    ..The proposal is made that an emergency cytokine regimen could be applied to nuclear accident victims as part of longer cytokine treatment, cell therapy, or both...
  29. ncbi Modification of radiation response in mice by Panax ginseng and diethyldithiocarbamate
    S H Kim
    Department of Anatomy, College of Veterinary Medicine, Chonnam National University, 300 Yongbong-dong, Puk-ku, Kwangju 500-757, South Korea
    In Vivo 15:407-11. 2001
    ..Further studies are needed to fully characterize the protective nature of ginseng extract and its components...
  30. pmc Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene
    Xichen Zhang
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Hum Gene Ther 19:820-6. 2008
    ..Intravenous, systemic administration of mc-MnSOD-PL protected mice from total body irradiation (9.75 Gy). Therefore, minicircle DNA containing the human MnSOD transgene confers undiminished radioprotection in vitro and in vivo...
  31. ncbi Alteration in the glutathione, glutathione peroxidase, superoxide dismutase and lipid peroxidation by ascorbic acid in the skin of mice exposed to fractionated gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 119, India
    Clin Chim Acta 332:111-21. 2003
    ....
  32. ncbi Radioprotective effects of amifostine (WR-2721) or cystamine on radiation damage and its repair in rats whole body exposed to fission neutrons
    Pavel Kuna
    Department of Radiology and Toxicology, Faculty of Health and Social Studies, University of South Bohemia, Ceske Budejovice, Czech Republic
    Acta Medica (Hradec Kralove) 47:19-23. 2004
    ..WR-2721 and cystamine i.m. were not able to increase 6 days reparation processes after sublethal 2 Gy fission neutrons whole body irradiated rats...
  33. ncbi [Time- and dose-dependent post-irradiation changes of Fe3+-transferrin and Cu2+-ceruloplasmin pools in blood, their influence on ribonucleotide reductase activity in animal tissues and the effects of radioprotectors]
    V L Sharygin
    Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia
    Radiats Biol Radioecol 43:662-77. 2003
    ..The key event ensuring the development of compensatory adaptive reactions is the increase of capacity of protein-synthesizing apparatus, the activation of biosynthesis of dNTP and DNA against the treatment with damaging factors...
  34. ncbi Modification of delayed radiation-induced reactions of duodenal vessels and mast cells in old rats
    V V Popuchiev
    Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk Institute of Industrial Organic Chemistry, Pschina, Poland
    Bull Exp Biol Med 136:399-403. 2003
    ..5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival...
  35. ncbi Polyherbal extract of septilin protects mice against whole body lethal dose of gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, India
    Phytother Res 18:619-23. 2004
    ..33%) which was used as a positive control. The LD(50) of Septilin was 1250 mg/kg as against the optimum protective dose of 100 mg/kg. Our study demonstrates Septilin as a good radioprotective agent...
  36. ncbi Radiomodulatory influence of Rajgira (Amaranthus paniculatus) leaf extract in Swiss albino mice
    J Maharwal
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, India
    Phytother Res 17:1150-4. 2003
    ..The results from the present study suggest that Rajgira pretreatment provide protection against gamma irradiation in mice...
  37. ncbi [Copper content in the blood of irradiated animals]
    L H Petryna
    Ivano Frankivsk Medical Academy
    Fiziol Zh 49:97-104. 2003
    ..5, 1, 2, 4, 6, 8, 10, 15, 20, 35, 45, 60, 90 and 120 days after exposing to irradiation. Maximal rate of changes in the content of copper in the blood of rats took place in 2-8 days after irradiation and were dose-dependent...
  38. ncbi Fruit extract of Aegle marmelos protects mice against radiation-induced lethality
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Integr Cancer Ther 3:323-32. 2004
    ....
  39. ncbi Amelioration of radiation-induced oxidative stress and biochemical alteration by SOD model compounds in pre-treated gamma-irradiated rats
    Mosaad A M Abou-Seif
    Chemistry Department, Faculty of Science, Mansoura University, El Mansura, Egypt
    Clin Chim Acta 337:23-33. 2003
    ....
  40. ncbi Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 119, India
    Radiat Res 160:584-92. 2003
    ..ZOE also had a dose-dependent antimicrobial activity against Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli and Candida albicans...
  41. ncbi Mentha piperita (Linn) leaf extract provides protection against radiation induced alterations in intestinal mucosa of Swiss albino mice
    R M Samarth
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Indian J Exp Biol 40:1245-9. 2002
    ..The results suggest that Mentha pretreatment provides protection against radiation induced alterations in intestinal mucosa of Swiss albino mice...
  42. ncbi Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of gamma-irradiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 119, Kamataka, India
    Nahrung 47:181-5. 2003
    ..wt. of SCE. However, the best protection was obtained for 30 mg/kg b.wt. SCE, where the number of, survivors after 30 days post-irradiation was highest (41.66%) when compared with the other doses of SCE...
  43. ncbi Elaeocarpus sylvestris modulates gamma-ray-induced immunosuppression in mice: implications in radioprotection
    Eunjin Park
    Department of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju 690 756, South of Korea
    Phytother Res 22:1046-51. 2008
    ..Therefore, it is concluded that the E.S. extract may be an effective agent of protection from radiation-induced injuries...
  44. ncbi Protective effect of an extract of Phyllanthus amarus against radiation-induced damage in mice
    K B Hari Kumar
    Amala Cancer Research Centre
    J Radiat Res 45:133-9. 2004
    ..amarus treatment, both in serum and liver. The results collectively indicate that P. amarus extract could increase the antioxidant defense mechanism in mice and there by protect the animals from radiation-induced cellular damage...
  45. ncbi Radioprotective effects of various cytokines in peripheral blood mononuclear cells and C3H mice
    Ju Young Kim
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Oncol Rep 13:1177-83. 2005
    ..These findings indicate that the combined treatment of IL-3 and SCF prevents the apoptosis induced in PBMCs by gamma-irradiation in vitro, but it does not afford any in vivo radioprotective effect in lethally irradiated C3H mice...
  46. ncbi Redox metal chelation ameliorates radiation-induced bone marrow toxicity in a mouse model
    R M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
    Radiat Res 156:205-9. 2001
    ..We suggest that radiation-induced toxicity is caused by the deleterious effect of redox-active metal ions, and that compounds which modulate this redox activity may act as radioprotectors...
  47. ncbi Evaluation of the radioprotective effect of Liv 52 in mice
    Ganesh C Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India
    Environ Mol Mutagen 47:490-502. 2006
    ....
  48. ncbi Radioprotective potential of Rosemarinus officinalis against lethal effects of gamma radiation : a preliminary study
    Archana Jindal
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    J Environ Pathol Toxicol Oncol 25:633-42. 2006
    ..The present study demonstrates that Rosemarinus officinalis leave extract is a good radioprotector...
  49. ncbi Guanosine and inosine as natural antioxidants and radioprotectors for mice exposed to lethal doses of gamma-radiation
    S V Gudkov
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia
    Dokl Biochem Biophys 407:47-50. 2006
  50. ncbi Radioprotection of Swiss albino mice by Myristica fragrans houtt
    Mini Sharma
    Cell and Molecular Biology Lab, Department of Zoology, University of Rajasthan, Jaipur, India
    J Radiat Res (Tokyo) 48:135-41. 2007
    ..The present study has implications for the potential use of MF as a radioprotector...
  51. ncbi Immunomodulatory and cytoprotective role of RP-1 in gamma-irradiated mice
    H C Goel
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Timarpur, Delhi, India
    Mol Cell Biochem 254:73-81. 2003
    ..05) reduced (1.23%) the radiation-induced MN frequency (2.9%) observed at 48 h post-irradiation interval. Since the radioprotective manifestation of RP-1 is mediated through multiple mechanisms, needs further investigation...
  52. ncbi [Effect of mexidol on hemopoietic system in conditions of an emotional stress after exposure to ionizing radiation]
    B B Moroz
    Radiats Biol Radioecol 47:163-70. 2007
    ..The pharmacological correction by mexidol from displays of an intensive emotional stress, developing after an irradiation in various doses, can be a part in system of medical measures...
  53. ncbi Prophylactic effect of flaxseed oil against radiation-induced hepatotoxicity in mice
    A L Bhatia
    Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 21:852-9. 2007
    ..The study does not rule out the possibility of a prophylactic potential of flaxseed oil against radiation-induced degenerative changes in liver...
  54. ncbi Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice
    Vipan Kumar Parihar
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal 576104, India
    Mutat Res 611:9-16. 2006
    ..There was no protection at a dose less than 25mg/kg bw...
  55. ncbi Acceleration of normal-tissue damage expression by early stimulation of cell proliferation in rat spinal cord
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Strahlenther Onkol 182:680-4. 2006
    ..To examine experimental strategies for prevention of radiation-induced late spinal cord damage...
  56. ncbi [Reactions of deoxyribonucleotide synthesis system to irradiation and their modification by radioprotectors]
    M K Pulatova
    Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia
    Radiats Biol Radioecol 43:29-43. 2003
    ..In vivo regulatory factors of dNTP synthesis have been studied to elucidate the mechanisms of getting of high and balanced dNTP pools by using of different substances...
  57. ncbi Modulatory influence of Adhatoda vasica Nees leaf extract against gamma irradiation in Swiss albino mice
    A Kumar
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India
    Phytomedicine 12:285-93. 2005
    ..A significant increase in the serum alkaline phosphatase activity and decrease in acid phosphatase activity was observed in A. vasica leaf extract pretreated irradiated animals during the entire period of study...
  58. ncbi Evaluation of insulin-like growth factor-1 for prevention of radiation-induced spinal cord damage
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Growth Factors 23:15-8. 2005
    ....
  59. ncbi Effects of Aegle marmelos (L.) Correa on the peripheral blood and small intestine of mice exposed to gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    J Environ Pathol Toxicol Oncol 25:611-24. 2006
    ..The data clearly indicate that the AME significantly reduced the deleterious effect of radiation in the intestine and bone marrow of mouse and could be a useful agent in reducing the side effects of therapeutic radiation...
  60. ncbi [Dependence of the therapeutic effectiveness of interleukin-1beta on the time of the drug administration after irradiation of mice]
    L M Rozhdestvenskiĭ
    State Research Centre of Russia Institute of Biophysics, Moscow, 123182 Russia
    Radiats Biol Radioecol 42:65-9. 2002
    ..There were analyzed the reasons of weaker betaleukin effect and shorter period of its effectiveness after exposure in comparison with literature data regarding IL-1...
  61. ncbi Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats
    Kannampalli Pradeep
    Radiation Research Division for Biotechnology, Korea Atomic Energy Research Institute, 1266 Shinjeong dong, Jeongeup, Jeonbuk 580 185, Republic of Korea
    Eur J Pharmacol 587:273-80. 2008
    ....
  62. doi Medicine. Drug bestows radiation resistance on mice and monkeys
    Yudhijit Bhattacharjee
    Science 320:163. 2008
  63. ncbi Studies on the protective effects of Boerhaavia diffusa L. against gamma radiation induced damage in mice
    K A Manu
    Amala Cancer Research Centre, Amala Nagar, Kerala State, India
    Integr Cancer Ther 6:381-8. 2007
    ..diffusa. These results are indicative of the radioprotective effect of the whole-plant extract of B. diffusa...
  64. ncbi Is growth hormone a radioprotective agent?
    S B Tekin
    Department of Medical Oncology, University Faculty of Medicine, Erzurum, Turkey
    J Eur Acad Dermatol Venereol 20:293-8. 2006
    ..These results are preliminary to studies that will be performed with higher doses of GH in radiation-treated cancer patients, with the aim of reducing radiation-induced toxicity...
  65. ncbi Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?
    S A Lorimore
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Oncogene 20:7085-95. 2001
    ....
  66. ncbi Radiation-induced production of PAR-1 and TGF-beta 1 mRNA in lung of C57Bl6 and C3H murine strains and influence of pharmacoprophylaxis by ACE inhibitors
    Radoslav Matej
    Department of Pathology, Thomayer Teaching Hospital, Videnska 800, Prague 4 Krc, 14059 Prague, Czech Republic
    Pathol Res Pract 203:107-14. 2007
    ..Thus, PAR-1 is involved in radiation-induced lung fibrosis in correlation with TGF-beta1 production. Administration of ACEI influences PAR-1 and TGF-beta1 expression...
  67. ncbi Morphological changes of rat jejunum after whole body gamma-irradiation and their impact in biodosimetry
    D Driak
    Gynaecological Obstetric Clinic, University Hospital Bulovka, Prague, Czech Republic
    Physiol Res 57:475-9. 2008
    ..This is in accordance with tasks and Standardization Agreement of the North Atlantic Treaty Organization...
  68. pmc PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome
    Wei Qiu
    Department of Pathology, University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Cell Stem Cell 2:576-83. 2008
    ..Therefore, PUMA-mediated apoptosis in the progenitor and stem cell compartments is crucial for radiation-induced intestinal damage...
  69. ncbi Role of free radicals on mechanism of radiation nephropathy
    B Balabanli
    Department of Biology, Gazi University Faculty of Arts and Science, 06500 Teknikokullar, Ankara, Turkey
    Mol Cell Biochem 293:183-6. 2006
    ..On the other hand we investigated whether the tissue damage can be prevented by vitamin A or not...
  70. ncbi Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture
    Aicha Laabich
    Acucela Inc, Seattle, Washington 98103, USA
    Invest Ophthalmol Vis Sci 47:3156-63. 2006
    ..The present study was performed to investigate the effect of crocin on blue light- and white light-induced rod and cone death in primary retinal cell cultures...
  71. ncbi The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats
    Liguang Chen
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 60:1520-9. 2004
    ..The purpose of this study was to determine whether rHuKGF prevents or ameliorates the severity of late lung damage from fractionated irradiation in a rat model...
  72. pmc Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress
    Yogita Kanan
    Department of Cell Biology, Universit of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 49:1071-8. 2008
    ..To understand their physiological roles, the authors investigated their expression during development and their regulation by light-induced oxidative stress in mouse retina...
  73. ncbi Experimental approach to improving early postirradiation restoration in the hemopoietic system of irradiated canines
    Lev Rozhdestvensky
    State Research Centre Institute of Biophysics, Moscow, Russia
    J Radiat Res 45:45-51. 2004
    ....
  74. ncbi The effects of Ligustrazine on the expression of bFGF and bFGFR in bone marrow in radiation injured mice
    Ning Wu
    Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Huazhong Univ Sci Technolog Med Sci 23:348-51. 2003
    ....
  75. ncbi Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury
    A Panoskaltsis-Mortari
    Department of Pediatrics, Heme Onc BMT Division, University of Minnesota, Minneapolis 55455, USA
    Blood 96:4350-6. 2000
    ..Blood. 2000;96:4350-4356)..
  76. ncbi The toxicity of insoluble cerium-144 inhaled by beagle dogs: non-neoplastic effects
    F F Hahn
    Inhalation Toxicology Laboratory, Lovelace Respiratory Research Institute, P O Box 5890, Albuquerque, New Mexico 87185, USA
    Radiat Res 155:95-112. 2001
    ....
  77. ncbi A representation of an NTCP function for local complication mechanisms
    M Alber
    Department of Medical Physics, , Germany
    Phys Med Biol 46:439-47. 2001
    ..The performance of the model was demonstrated with an animal model which has been published previously (Powers et al 1998 Radiother. Oncol. 46 297-306)...
  78. ncbi [Prediction of the severity of damage and disruption of work ability in reaction of the body to alcohol load prior to radiation exposure in the superlethal range]
    N G Darenskaia
    State Research Center Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia
    Radiats Biol Radioecol 42:260-7. 2002
    ..In 65% monkeys high similarity of the reactions to AI and ionizing radiation was observed...
  79. ncbi Acute ocular injuries caused by 60-Ghz millimeter-wave exposure
    Masami Kojima
    Division of Vision Research for Environmental Health, Medical Research Institute, Kanazawa Medical University, 1 1, Daigaku, Uchinada machi, Ishikawa, 920 0293, Japan
    Health Phys 97:212-8. 2009
    ..These findings indicate that the three types of millimeter-wave antennas can cause thermal injuries of varying types and levels. The thermal effects induced by millimeter-waves can apparently penetrate below the surface of the eye...
  80. ncbi Clinical implications of incomplete repair parameters for rat spinal cord: the feasibility of large doses per fraction in PDR and HDR brachytherapy
    L A Pop
    Institute of Radiotherapy, University of Nijmegen, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 51:215-26. 2001
    ....
  81. ncbi Toxicity of ultraviolet radiation exposure to the lens expressed by maximum tolerable dose
    P G Söderberg
    Research Department, St Erik s Eye Hospital, Karolinska Institutet, Fleminggatan 22, SE 112 82 Stockholm, Sweden
    Dev Ophthalmol 35:70-5. 2002
    ..It has, however, recently been shown that UVR-induced cataract is a continuous dose-dependent event. MTD provides a statistically well-defined criterion of toxicity for continuous response events...
  82. ncbi Role of CD13/aminopeptidase N in rat lymphocytic alveolitis caused by thoracic irradiation
    Luping Huang
    Third Department of Internal Medicine, School of Medicine, Tokushima University, Tokushima, Japan
    Radiat Res 157:191-8. 2002
    ..This study suggests that CD13/aminopeptidase N may play an important role as a lymphocyte chemoattractant in lymphocyte-mediated alveolitis in experimental radiation-induced lung injury...
  83. ncbi Repeated UVR exposures cause keratocyte resistance to apoptosis and hyaluronan accumulation in the rabbit cornea
    A Podskochy
    St Eriks Eye Hospital, Polhemsgatan 50, S 112 82 Stockholm, Sweden
    Acta Ophthalmol Scand 79:603-8. 2001
    ..To evaluate hyaluronan (HA) production and level of apoptosis of corneal cells after repeated UVR exposures...
  84. ncbi Down-regulation of SP1 DNA binding activity in the process of radiation-induced pulmonary fibrosis
    M Haase
    Institut fur Pathologie, TU Dresden, Germany
    Int J Radiat Biol 76:487-92. 2000
    ..To determine changes in the expression and function of the transcription factor SP1 in radiation-induced pulmonary fibrosis...
  85. ncbi The evaluation of the radioprotective effect of chyavanaprasha (an ayurvedic rasayana drug) in mice exposed to lethal dose of gamma-radiation: a preliminary study
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Phytother Res 18:14-8. 2004
    ..The drug was non-toxic up to a dose of 6 g/kg b. wt., the highest drug dose that could be tested. Our study demonstrates that chyavanaprasha can provide good radioprotection at a very low non-toxic dose...
  86. ncbi [Cytokine production by different population of macrophages following radiation or combined radiation injury]
    R S Budagov
    Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249020 Russia
    Radiats Biol Radioecol 40:684-7. 2000
    ..There were no significant differences of cytokine-producing activity if macrophages were harvested from irradiated or combined injured mice...
  87. ncbi Evaluation of the radioprotective effect of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 119, India
    J Pharm Pharmacol 55:1151-8. 2003
    ..ACE was found to scavenge DPPH radicals in a concentration-dependent manner, indicating that the radioprotection afforded by ACE may be in part due to the scavenging of reactive oxygen species induced by ionizing radiation...
  88. ncbi Monitoring radiation-induced changes in bone marrow histopathology with ultra-small superparamagnetic iron oxide (USPIO)-enhanced MRI
    H E Daldrup
    Institute of Clinical Radiology, University of Munster, Germany
    J Magn Reson Imaging 9:643-52. 1999
    ..Irradiation-induced changes in bone marrow physiology could be reliably assessed with AMI-227-enhanced MRI...
  89. ncbi Immunostimulating effects of sugar cane extract on X-ray radiation induced immunosuppression in the chicken
    Said Amer
    National Institute of Animal Health, National Agricultural Research Organization, 3 1 5, Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Int Immunopharmacol 4:71-7. 2004
    ....
  90. ncbi A low-energy x-ray irradiator for electrophysiological studies
    D A Schauer
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 5145
    Int J Rad Appl Instrum A 40:7-17. 1989
    ..Electrophysiological recordings of subtle changes in neuronal activity indicate this system is suitable for this application...
  91. ncbi On radiation damage to normal tissues and its treatment. II. Anti-inflammatory drugs
    A S Michalowski
    MRC Cyclotron Unit, Hammersmith Hospital, London, UK
    Acta Oncol 33:139-57. 1994
    ..Further studies on anti-inflammatory drug treatment of radiation damage to normal organs are justified and desirable...
  92. ncbi The role of tumor necrosis factor signaling pathways in the response of murine brain to irradiation
    J L Daigle
    Roy E Coats Research Laboratories, Department of Radiation Oncology, University of California, Los Angeles, California 90095 1714, USA
    Cancer Res 61:8859-65. 2001
    ..These observations indicate that radiation-induced TNF-alpha, acting through TNFRp75, protects against the development of late complications of brain irradiation...
  93. ncbi Persistence of genetic damage in mice exposed to low dose of X rays
    Anna Giovanetti
    ENEA ION IRP Ente per le Nuove Tecnologie, l Energia e l Ambiente Istituto di Radioprotezione, Research Centre Casaccia, Rome, Italy
    Int J Radiat Biol 84:227-35. 2008
    ..The aim of this work was to evaluate the persistence of genetic damage in CBA/J mice treated with a single irradiation of 0.1 or 1 Gy of X rays...
  94. pmc The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina
    Travis J Bailey
    Department of Biological Sciences and the Center for Zebrafish Research, University of Notre Dame, Galvin Life Science Building, Notre Dame, IN 46556, USA
    Exp Eye Res 91:601-12. 2010
    ..This implies that at least one signaling mechanism, in addition to the process disrupted by L-SOP, is required to activate Müller glia proliferation in the light-damaged retina...
  95. ncbi Bone marrow CD34+ cells expanded on human brain endothelial cells reconstitute lethally irradiated baboons in a variable manner
    Hiroto Araki
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago, IL, USA
    Leuk Lymphoma 51:1121-7. 2010
    ....
  96. ncbi In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature
    Raphael Serduc
    INSERM, U 594, Functional and Metabolic Neuroimaging, Grenoble, France Université Joseph Fourier Grenoble, Grenoble, France
    Int J Radiat Oncol Biol Phys 64:1519-27. 2006
    ..The purpose of this study was to assess the early effects of microbeam irradiation on the vascular permeability and volume in the parietal cortex of normal nude mice using two-photon microscopy and immunohistochemistry...
  97. ncbi [Experimental study on brachial plexus injury induced by radiation in rats]
    Zhigang Liu
    Department of Hand Surgery, First Hospital of Jilin University, Changchun Jilin 130021, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21:953-6. 2007
    ....
  98. ncbi Acute dorsal skin responses to UVB-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats
    K Kuroki
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Japan
    Exp Toxicol Pathol 53:1-6. 2001
    ..Thus WBN/ILA-Ht rats were more sensitive to UVB-irradiation than Wistar rats, and WBN/ILA-Ht rats was considered to be a useful experimental animal in the field of photodermatology...
  99. ncbi Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets
    R Stoffel
    Department of Pharmacology, University of Basel, Switzerland
    Blood 87:567-73. 1996
    ..Our results are consistent with TPO protein being regulated at a posttranscriptional level and/or directly through absorption and metabolism by platelets...
  100. ncbi Evolution of a focal brain lesion produced by interlaced microplanar X-rays
    D J Anschel
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Minim Invasive Neurosurg 50:43-6. 2007
    ..Interlaced microbeams is an effective method to create focal brain microlesions. This technique may allow the future treatment of pathology not accessible by surgical or more traditional radiosurgical means...
  101. ncbi Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development
    Vladislava O Melnikova
    Department of Immunology, The University of Texas MD Anderson Cancer Center, PO Box 301402, Unit 902, Houston, TX 77030, USA
    Oncogene 24:7055-63. 2005
    ....

Research Grants30

  1. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 2003
    ..In addition, the time course of the appearance of cytoplasmic cytochrome C and the activation of cellular caspases will be determined by antibody-based techniques, immunocytochemistry and enzymatic analysis. ..
  2. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  3. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
    ..abstract_text> ..
  4. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2006
    ..unreadable] 4) Complete the randomized, prospective, trial of the use of ACE inhibitors to prevent the development of radiation nephropathy in BMT patients. [unreadable] [unreadable]..
  5. OXIDATIVE STRESS AND CATARACT FORMATION
    Shambhu D Varma; Fiscal Year: 2010
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  6. STAGE SPECIFIC EXPRESSION OF CD34 IN EARLY HEMATOPOIESIS
    Diane Krause; Fiscal Year: 2001
    ..Also, a better understanding of the molecular control for early hematopoiesis will improve our ability to combat selective cytopenias and aplastic anemia. ..
  7. Mechanism of hypoxia mediated radiation lung injury
    Zeljko Vujaskovic; Fiscal Year: 2006
    ..abstract_text> ..
  8. CHOLESTEROL & PLAQUE RUPTURE--WOMEN AND PLAQUE EROSION
    Renu Virmani; Fiscal Year: 2001
    ..In addition, analysis of plaque morphology in the animal model proposed in Project 4 will be carried out in project 1. ..
  9. A New Antioxidant Prevents Toxicity of HIV Proteins with Methamphetamine
    Nuran Ercal; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. UW Oshkosh Animal Facility Improvement
    DANA VAUGHAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
    ..These will aid in the search for initiating events and the mechanisms leading up to the cataract formation. ..
  12. Rescue of radiation-induced salivary gland dysfunction by Akt
    KIRSTEN LIMESAND; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Gene Modifiers of Retinal Degeneration
    HENRY DANCIGER; Fiscal Year: 2009
    ..This would make therapeutic approaches simpler. ..
  14. EVALULATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUM
    Richard Coutts; Fiscal Year: 2001
    ..The goal is to develop an implant that will consistently and predictably produce repairs of full-thickness articular cartilage defects that will function as well as normal cartilage. ..
  15. Plaque Progression, Apoptosis and Inflammation
    Renu Virmani; Fiscal Year: 2005
    ..abstract_text> ..
  16. Suppression of Salivary Gland Apoptosis by AKt
    KIRSTEN LIMESAND; Fiscal Year: 2003
    ..These studies will provide greater insight to the understanding of this tissue and potentially provide clinical treatment of cancer-induced apoptosis in salivary glands. ..
  17. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  18. STRUCTURAL BASES FOR OPTICAL PROPERTIES OF CORNEAS
    RUSSELL MCCALLY; Fiscal Year: 2004
    ..For the rabbit study, resolution and F.A.C.T. charts will be imaged through freshly excised corneas and the potential degradation in visual performance will be correlated with scatterometer measurements. ..
  19. Epithelial engraftment of bone marrow derived stem cells
    Diane Krause; Fiscal Year: 2008
    ..The data obtained will lead us to design novel therapeutic strategies tissue injury and disease. [unreadable] [unreadable] [unreadable]..
  20. Effect of Estrogen on Radiation-induced Cataractogenesis
    JOSEPH DYNLACHT; Fiscal Year: 2005
    ..abstract_text> ..
  21. The Role of the Mre11 Complex in Heat-radiosensitization
    JOSEPH DYNLACHT; Fiscal Year: 2007
    ..We will also determine the role of HR in heat-radiosensitization using silencing RNA (siRNA) targeting technology or conditional mutants deficient in specific NHEJ or HR proteins. [unreadable] [unreadable]..
  22. Identifying Cytoprotectants for Photoreceptors and RPE Cells to Treat Dry AMD
    Susan Henry; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. PECAM-1 AND REGULATION OF ANGIOGENESIS
    Nader Sheibani; Fiscal Year: 2003
    ..It is suggested that a therapeutic benefit can be derived by exploiting these signaling pathways to control the hypervascularization characteristic of arthritis. ..
  24. Retinal Circadian Signaling in a Transgenic Model
    Allan Wiechmann; Fiscal Year: 2004
    ..Discovering the molecular mechanisms of melatonin action may therefore provide a greater understanding of the role of circadian signals in environmentally- and genetically- induced photoreceptor degenerations. ..
  25. Molecular Mechanisms of Aging: 33rd Ann. Mtg. of AGE
    Norman Wolf; Fiscal Year: 2004
    ..Dr. Bickford has investigated hotel accommodations there and has found that both the Radisson and the Hilton offer excellent accommodations for the meeting. She is negotiating with both. ..
  26. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
    ..We expect to isolate common downstream target genes that are activated both during degeneration and neuroprotection. ..
  27. Transgenic Rod Development and Function
    Baerbel Rohrer; Fiscal Year: 2005
    ..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
  28. Thrombospondin-1 and retininal vascular homeostasis
    Nader Sheibani; Fiscal Year: 2005
    ..This knowledge will provide the rationale for development of new therapeutic approaches for the prevention and/or treatment of ocular diseases with a neovascular component. ..