animal hepatitis

Summary

Summary: INFLAMMATION of the LIVER in non-human animals.

Top Publications

  1. ncbi Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice
    Mei Gao
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Liver Int 25:904-12. 2005
  2. pmc Isolation of Helicobacter cinaedi from the colon, liver, and mesenteric lymph node of a rhesus monkey with chronic colitis and hepatitis
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 39:1580-5. 2001
  3. ncbi Helicobacter bilis-associated hepatitis in outbred mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Comp Med 54:571-7. 2004
  4. ncbi Melatonin-selenium nanoparticles protects liver against immunological injury induced by bacillus Calmette-Guerin and lipopolysaccharide
    Hua Wang
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China
    Acta Pharmacol Sin 26:745-52. 2005
  5. ncbi Mechanism of protective action of bicyclol against CCl-induced liver injury in mice
    Geng Tao Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Liver Int 25:872-9. 2005
  6. ncbi Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis
    Xiaoxing Xiang
    Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Chin Med J (Engl) 115:593-6. 2002
  7. ncbi [Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage]
    M Bilzer
    Medizinische Klinik II, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munchen
    Z Gastroenterol 40:543-4. 2002
  8. ncbi Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
    Maria L Martinez-Chantar
    Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine, University of Navarra, Pamplona, Spain
    FASEB J 16:1292-4. 2002
  9. ncbi Double-blind, placebo-controlled study of the efficacy of nandrolone laurate in the treatment of dobermanns with subclinical hepatitis
    P J J Mandigers
    Department of Clinical Sciences of Companion Animals, PO Box 80154, University of Utrecht, 3508 TD Utrecht, The Netherlands
    Vet Rec 157:313. 2005
  10. ncbi IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver
    Osama El-Assal
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 1:205-11. 2004

Research Grants

Detail Information

Publications152 found, 100 shown here

  1. ncbi Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice
    Mei Gao
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Liver Int 25:904-12. 2005
    ..These results suggest that DDB could directly protect hepatocyte DNA from oxidative damage, and inhibit TNF-alpha mRNA expression in liver tissue, which resulted in prevention of liver damage induced by Con A in mice...
  2. pmc Isolation of Helicobacter cinaedi from the colon, liver, and mesenteric lymph node of a rhesus monkey with chronic colitis and hepatitis
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 39:1580-5. 2001
    ..This is the first observation of H. cinaedi associated with active hepatitis and colitis in a nonhuman primate...
  3. ncbi Helicobacter bilis-associated hepatitis in outbred mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Comp Med 54:571-7. 2004
    ..bilis-infected mice of group III seroconverted to H. bilis outer membrane antigen. Helicobacter bilis infection is associated with hepatitis in SW mice and can confound experimental results...
  4. ncbi Melatonin-selenium nanoparticles protects liver against immunological injury induced by bacillus Calmette-Guerin and lipopolysaccharide
    Hua Wang
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China
    Acta Pharmacol Sin 26:745-52. 2005
    ..The present investigation was designed to determine the protective effects of MT-Se against immunological liver injury in mice induced by bacillus Calmette-Guerin (BCG)/lipopolysaccharide (LPS)...
  5. ncbi Mechanism of protective action of bicyclol against CCl-induced liver injury in mice
    Geng Tao Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Liver Int 25:872-9. 2005
    ..These results suggest that bicyclol has remarkable hepatoprotective effects and its mechanism of action may be related to a decrease in free radical-induced damage to hepatocytes...
  6. ncbi Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis
    Xiaoxing Xiang
    Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Chin Med J (Engl) 115:593-6. 2002
    ..To evaluate the protective effects and mechanism of action of oxymatrine (OM) on the experimental fulminant hepatitis (FH) and early hepatocyte apoptosis in murine liver tissue...
  7. ncbi [Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage]
    M Bilzer
    Medizinische Klinik II, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munchen
    Z Gastroenterol 40:543-4. 2002
  8. ncbi Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
    Maria L Martinez-Chantar
    Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine, University of Navarra, Pamplona, Spain
    FASEB J 16:1292-4. 2002
    ..Taken together, our findings define a critical role for S-adenosylmethionine in maintaining normal hepatic function and tumorigenesis of the liver...
  9. ncbi Double-blind, placebo-controlled study of the efficacy of nandrolone laurate in the treatment of dobermanns with subclinical hepatitis
    P J J Mandigers
    Department of Clinical Sciences of Companion Animals, PO Box 80154, University of Utrecht, 3508 TD Utrecht, The Netherlands
    Vet Rec 157:313. 2005
    ....
  10. ncbi IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver
    Osama El-Assal
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 1:205-11. 2004
    ....
  11. ncbi Loss of immunogenecity of liver dendritic cells from mouse with chronic hepatitis
    Masanori Abe
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Toshima ku, Tokyo 170 8455, Japan
    Int J Mol Med 9:71-6. 2002
    ..Defective capacity of liver DC from mouse with chronic hepatitis (IFN-gamma TgM) may be related to impaired magnitude of specific immune response in the liver...
  12. ncbi Influence of disease stage on polyethylenimine-mediated plasmid DNA delivery in murine hepatitis
    Hitoshi Sasaki
    Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Pharm 318:139-45. 2006
    ..These results indicate the necessity of considering the timing and dose of gene therapy according to the disease stage...
  13. ncbi Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis
    J D Gorham
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 166:6413-22. 2001
    ..This represents the first murine model of hepatitis that develops spontaneously, is restricted by genetic background, and is dependent upon the Th1 cytokine IFN-gamma, and that thus recapitulates these important aspects of AIH...
  14. ncbi Antinecrotic and antiapoptotic effects of hepatocyte growth factor on cholestatic hepatitis in a mouse model of bile-obstructive diseases
    Zhaodong Li
    Division of Molecular Regenerative Medicine, Dept of Biochemistry and Molecular Biology, Osaka Univ Graduate School of Medicine, Yamadaoka 2 2 B7, Suita, Osaka, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G639-46. 2007
    ....
  15. ncbi Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways
    Yan Xu
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, People s Republic of China
    J Clin Immunol 28:512-9. 2008
    ..The aim of this study was to investigate the effect of STS on concanavalin A (ConA)-induced hepatitis (CIH) in mice, an experimental model of immune-mediated liver injury...
  16. ncbi Mice lacking inducible nitric oxide synthase show strong resistance to anti-Fas antibody-induced fulminant hepatitis
    BaoJun Chang
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno, 545 8585, Osaka, Japan
    Arch Biochem Biophys 411:63-72. 2003
    ..In conclusion, these observations suggest that regulation of NO metabolism may have therapeutic potential in the treatment of patients with fulminant hepatitis...
  17. pmc A monoclonal antibody to the alpha2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model
    Shuji Matsuoka
    Department of Pathology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 198:497-503. 2003
    ....
  18. ncbi A multistep approach in the cytologic evaluation of liver biopsy samples of dogs with hepatic diseases
    C Stockhaus
    Department of Small Animals, University of Leipzig, Germany
    Vet Pathol 41:461-70. 2004
    ..In summary, the stepwise approach based on logistic regression presented in this study might be helpful in the objective cytologic diagnosis of hepatic diseases...
  19. ncbi IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1
    Barbara Jaruga
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1044-52. 2004
    ....
  20. ncbi Tetrathiomolybdate in the treatment of acute hepatitis in an animal model for Wilson disease
    Dominik Klein
    Institute of Toxicology and Environmental Hygiene, Technical University Munich, Germany
    J Hepatol 40:409-16. 2004
    ..Here, we investigate the potential use of TTM in treating the acute hepatic copper toxicosis in Long-Evans Cinnamon (LEC) rats, an authentic model for Wilson disease...
  21. ncbi IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners
    Rui Sun
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:5648-55. 2004
    ..Taken together, these findings suggest that in addition to its antiapoptotic abilities, as previously well documented, IL-6/STAT3 inhibits NKT cells via targeting CD4(+) T cells and consequently prevents T cell-mediated hepatitis...
  22. ncbi Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice
    Keishi Adachi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 16:787-98. 2004
    ..berghei-induced liver injury. Our studies may have general implications for tissue injuries that are caused by 'bystander killing' or other poorly defined cell-mediated killing mechanisms...
  23. ncbi B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes
    Haidong Dong
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Immunity 20:327-36. 2004
    ..Therefore, B7-H1 is a key protein selectively regulating the accumulation and deletion of intrahepatic CD8(+) T cells and may also contribute to inflammation, autoimmune diseases, and tolerance in the liver...
  24. ncbi Fumonisin B1 hepatotoxicity in mice is attenuated by depletion of Kupffer cells by gadolinium chloride
    Quanren He
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Toxicology 207:137-47. 2005
    ..Decreased FB1-induced sphinganine accumulation and increased protective TNFalpha signaling by gadolinium chloride may in part account for its ameliorating effect on FB1 liver damage...
  25. ncbi Protective effect of baicalin on tert-butyl hydroperoxide-induced rat hepatotoxicity
    Jin Ming Hwang
    Department of Biochemistry, Medical College, Chung Shan Medical University, No 110, Section 1, Chien Kuo N Rd, 402 Taichung, Taiwan
    Arch Toxicol 79:102-9. 2005
    ..Based on the results described above, we speculate that baicalin may play a chemopreventive role via reducing oxidative stress in living systems...
  26. ncbi Improvement in liver pathology after 4 months of D-penicillamine in 5 doberman pinschers with subclinical hepatitis
    P J J Mandigers
    Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    J Vet Intern Med 19:40-3. 2005
    ..However, because D-penicillamine has both copper-chelating and anti-inflammatory properties, it is not possible to draw conclusions on the etiology of this disease...
  27. ncbi Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene
    Yan Meng
    Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Biochim Biophys Acta 1690:208-19. 2004
    ..This first successful transgenic rescue has important implications for the gene therapy of WD...
  28. ncbi Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression
    Yan Mei Yang
    Molecular Biology Center, Shantou University Medical College, Shantou, Guangdong 515041, People s Republic of China
    Toxicol Sci 85:727-34. 2005
    ..EROD activities, CYP1A1 expression, and AhR mRNA expression in vitamin A + TCDD-treated mice were lower than those in TCDD-treated mice, indicating that supplementation of vitamin A might attenuate the liver damage caused by TCDD...
  29. ncbi Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes
    Barbara Jaruga
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:3233-44. 2003
    ....
  30. ncbi Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody
    P Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Italy
    Cell Death Differ 10:997-1004. 2003
    ..The precise cellular and molecular details underlying this interplay between Fas- and TNFRs-mediated signaling systems in the general and liver-specific aFas toxicity largely remain to be clarified...
  31. ncbi Association between liver copper concentration and subclinical hepatitis in Doberman Pinschers
    P J J Mandigers
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    J Vet Intern Med 18:647-50. 2004
    ..The results of this study suggest that there is a relationship among copper storage, hepatocellular damage, and hepatitis in Doberman Pinschers...
  32. ncbi Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviral cytotoxic T cell responses
    B Ludewig
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    J Immunol 166:3369-76. 2001
    ..These findings impinge on our understanding of hypercholesterolemia as a disease parameter and may explain aspects of the frequent association of persistent pathogens with hypercholesterolemia-induced diseases, such as atherosclerosis...
  33. ncbi Enhanced expression of transforming growth factor-beta 1 in inflammatory cells, alpha-smooth muscle actin in stellate cells, and collagen accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice
    Ming Shun Wu
    Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Acta Trop 105:260-8. 2008
    ....
  34. ncbi Hepatitis with special reference to dogs. A review on the pathogenesis and infectious etiologies, including unpublished results of recent own studies
    S Y Boomkens
    Department of Clinical Sciences of Companian Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Vet Q 26:107-14. 2004
    ....
  35. pmc Critical contribution of liver natural killer T cells to a murine model of hepatitis
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 97:5498-503. 2000
    ..These results implicated FasL expression on liver NKT cells in the pathogenesis of Con A-induced hepatitis, suggesting a similar pathogenic role in human liver diseases such as autoimmune hepatitis...
  36. ncbi TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax
    Gabriele Sass
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 179:7042-9. 2007
    ....
  37. ncbi Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production
    H Tsuji
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Immunol 162:1049-55. 1999
    ..Thus, endogenously produced IFN-gamma is involved in the pathogenesis of this liver injury model by regulating Mphi infiltration and granuloma formation in the priming phase as well as cytokine production in the eliciting phase...
  38. pmc Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses
    D W Hartwell
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 143:1129-41. 1998
    ..Our results suggest that different sorting mechanisms for P-selectin are used in platelets and endothelial cells and that the storage pool of P-selectin in endothelial cells is functionally important during early stages of inflammation...
  39. pmc Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis
    Jun Yu
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Gut 56:991-9. 2007
    ..However, it is not known whether overexpression of COX-2 in the liver is sufficient to promote activation or secretion of inflammatory factors leading to hepatitis...
  40. ncbi Development of anorexia in concanavalin A-induced hepatitis in mice
    T Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, 1-22 Hikokawato, Misato, Saitama 341-0005, Japan
    Int J Mol Med 7:169-72. 2001
    ..The present results indicate that treatment of mice with concanavalin A caused the development of anorexia and that this anorexia might develop independently of the induction of hepatitis...
  41. ncbi Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives
    T Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, 1-22 Hikokawato, Misato, Saitama 341-0005, Japan
    Int J Mol Med 7:177-80. 2001
    ..The present results showed the inhibition of anti-Fas antibody-induced hepatitis by imperatorin and Y355, which might be a result of inhibition of caspase activities...
  42. ncbi Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes
    Y Tagawa
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 159:1418-28. 1997
    ..These observations suggest that IFN-gamma plays a central role in Con A-hepatitis by activating Fas-induced apoptosis of liver cells...
  43. ncbi Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients
    Hans J J van der Vliet
    Department of Internal Medicine, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Clin Immunol 114:183-9. 2005
    ..involved in the regulation of various immune responses, and have been shown to inhibit viral replication in animal hepatitis models when activated by the glycolipid alpha-galactosylceramide (alpha-GalCer, KRN7000)...
  44. ncbi [Hepatic nodules in...a hare!]
    Paul Henri Dumas
    Laboratoire Vétérinaire Départemental de la Somme, 31 avenue Paul Claudel, 80480 Dury les Amiens
    Ann Pathol 23:368-70. 2003
  45. ncbi Antiviral activity of ganciclovir, 9-(1,3-dihydroxy-2-propoxymethyl) guanine against woodchuck hepatitis virus: quantitative measurement of woodchuck hepatitis virus DNA using storage phosphor technology
    F E Zahm
    F Hoffman La Roche Ltd, Basel, Switzerland
    Ital J Gastroenterol Hepatol 30:510-6. 1998
    ..We compared two different quantification methods of woodchuck hepatitis virus DNA...
  46. pmc Critical roles of TRAIL in hepatic cell death and hepatic inflammation
    Shi Jun Zheng
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 113:58-64. 2004
    ..Thus, TRAIL plays a crucial role in hepatic cell death and hepatic inflammation...
  47. ncbi Extrapulmonary disorders associated with Rhodococcus equi infection in foals: 150 cases (1987-2007)
    Sarah M Reuss
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    J Am Vet Med Assoc 235:855-63. 2009
    ....
  48. pmc Experimental acute respiratory Burkholderia pseudomallei infection in BALB/c mice
    Mark S Lever
    Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, UK
    Int J Exp Pathol 90:16-25. 2009
    ..These results suggest that the BALB/c mouse is highly susceptible to B. pseudomallei by the aerosol route and represents a relevant model system of acute human melioidosis...
  49. pmc Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes
    B L Haller
    Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110
    J Virol 69:357-64. 1995
    ..Organs (the brain and intestines versus the liver) differ in properties that determine which virulence genes, and thus which parts of this structural unit, are important...
  50. ncbi Chronic hepatitis in Doberman pinschers. A review
    P J J Mandigers
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Vet Q 26:98-106. 2004
    ..Based on recent findings chronic hepatitis in Doberman pinschers is most likely to be a form of copper toxicosis. Although there are several indications that suggest autoimmunity as well, this still remains unclear...
  51. ncbi Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis
    Naoko Watanabe
    Department of Clinical Laboratory Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Thromb Haemost 102:389-96. 2009
    ....
  52. ncbi Skin fragility syndrome in a cat with cholangiohepatitis and hepatic lipidosis
    Alexandre G T Daniel
    College of Veterinary Medicine and Animal Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Feline Med Surg 12:151-5. 2010
    ..Findings were consistent with feline skin fragility syndrome associated with cholangiohepatitis and hepatic lipidosis...
  53. ncbi Enhanced inducible nitric oxide synthase expression and nitrotyrosine accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice
    C K Fan
    Department of Parasitology, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    Parasite Immunol 26:273-81. 2004
    ..593, P = 0.021) in the trial. Our present results indicate a potential therapeutic strategy for treatment of GH caused by other nematodes through manipulation of iNOS expression...
  54. ncbi Necrotic hepatitis due to Clostridium perfringens infection in newly hatched broiler chicks
    Jun Sasaki
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Iwate, Japan
    J Vet Med Sci 65:1249-51. 2003
    ..The main histological finding was well demarcated multi-focal necrosis in the liver. Many Gram-positive large bacilli that reacted positively with polyclonal anti-Clostridium perfringens serum were observed in necrotic areas...
  55. ncbi Assessment of increased serum aminotransferases in a managed Atlantic bottlenose dolphin (Tursiops truncatus) population
    Stephanie Venn-Watson
    US Navy Marine Mammal Program, Space and Naval Warfare Systems Center, San Diego, California 92152, USA
    J Wildl Dis 44:318-30. 2008
    ....
  56. pmc Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver
    Romi Ghose
    Texas Children s Liver Center Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Hepatol 46:115-23. 2007
    ....
  57. ncbi Enterohepatic Helicobacter species isolated from the ileum, liver and colon of a baboon with pancreatic islet amyloidosis
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Med Microbiol 55:1591-5. 2006
    ..To the best of the authors' knowledge, this is the first report describing the isolation of enterohepatic Helicobacter species from a baboon...
  58. ncbi Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum
    Yan Qun Li
    College of Life Science, South China Normal University, Guangzhou 510631, PR China
    Biotechnol Lett 28:837-41. 2006
    ..Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8)...
  59. ncbi Differentiating benign and malignant causes of lymphocytosis in feline bone marrow
    Douglas J Weiss
    Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    J Vet Intern Med 19:855-9. 2005
    ..Cat age, presence of severe anemia, and evidence of inflammatory disease also should be considered...
  60. ncbi Expression of epidermal growth factor in transgenic mice causes growth retardation
    S Y Chan
    Department of Paediatrics, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Biol Chem 275:38693-8. 2000
    ..In contrast to previous reports on TGF-alpha transgenic mice, we show that the biological functions of EGF and TGF-alpha are clearly distinct...
  61. pmc The kinase inhibitor imatinib mesylate inhibits TNF-{alpha} production in vitro and prevents TNF-dependent acute hepatic inflammation
    Anna Maria Wolf
    Department of Gastroenterology and Hepatology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 102:13622-7. 2005
    ..These findings suggest a potent antiinflammatory role of imatinib by modulation of TNF-alpha production in monocytes/macrophages. This observation might be of therapeutic value for the treatment of TNF-mediated diseases...
  62. pmc micro-Opioid receptor activation prevents acute hepatic inflammation and cell death
    Dania Chakass
    Institut National de la Santé et de la Recherche Médicale INSERM U795, University of Lille 2, Digestive Tract Diseases and Nutrition Department, 59037, Lille Cedex, France
    Gut 56:974-81. 2007
    ....
  63. ncbi Sublobular veins as the main site of lymphocyte adhesion/transmigration and adhesion molecule expression in the porto-sinusoidal-hepatic venous system during concanavalin A-induced hepatitis in mice
    H Morikawa
    Department of Anatomy, Osaka City University Medical School, Osaka, Japan
    Hepatology 31:83-94. 2000
    ..e., E-selectin and VCAM-1 expression and lamellipodia formation...
  64. pmc A colorimetric assay method to measure acetyl-CoA synthetase activity: application to woodchuck model of hepatitis virus-induced hepatocellular carcinoma
    Yu Kuang
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biochem Biophys Methods 70:649-55. 2007
    ..The developed assay is rapid, simple and accurate and is suitable for the investigation of ACAS activity under physiologic and pathophysiologic conditions...
  65. ncbi [Gene expressions of LTC4 synthase homologs in Con A-induced mouse hepatitis and regulative effect of cyclosporine A]
    Luo Yang Qi
    Institute of Pharmacology and Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:241-6. 2007
    ..To explore the gene expressions of LTC4 synthase homologs in concanavalin A (Con A)-induced mouse hepatitis and regulation role of cyclosporine A (Cs A) treatment...
  66. ncbi Modifications in P62 occur due to proteasome inhibition in alcoholic liver disease
    Fawzia Bardag-Gorce
    Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Life Sci 77:2594-602. 2005
    ..P62 protein levels were also increased in the purified proteasome fraction of rats given PS-341. This data indicates that modifications in P62 occur due to proteasome inhibition in experimental alcoholic liver disease...
  67. ncbi Requirement of peptidergic sensory innervation for disease activity in murine models of immune hepatitis and protection by beta-adrenergic stimulation
    G Tiegs
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    J Neuroimmunol 96:131-43. 1999
    ..Hence, strategies reducing the activity of peptidergic sensory nerve fibres or stimulating beta2-adrenoreceptors, may be of benefit in immune-mediated liver disease...
  68. pmc Methionine deficiency and hepatic injury in a dietary steatohepatitis model
    Helieh S Oz
    Center for the Oral Health Research, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Dig Dis Sci 53:767-76. 2008
    ..These data support a pivotal role for methionine in the pathogenesis of the dietary model of Meth-choline-deficient (MCD) steatohepatitis (NASH)...
  69. ncbi Diminished acute phase response and increased hepatic inflammation of aged rats in response to intraperitoneal injection of lipopolysaccharide
    Christian R Gomez
    National Institute on Aging, NIA NIH, Bethesda MD 20892, USA
    J Gerontol A Biol Sci Med Sci 63:1299-306. 2008
    ..Our results suggest that aged rats displayed a reduced expression of APPs and increased hepatic injury in response to the inflammatory insult...
  70. pmc Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation
    Kimberly L Fife
    Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
    J Pharmacol Exp Ther 327:707-15. 2008
    ..However, LPS did have significant effects on plasma eicosanoid levels and hepatic Ephx2 expression, suggesting that in vivo EET levels are modulated in response to an inflammatory signal...
  71. ncbi Chronic hepatitis associated with canine leishmaniosis (Leishmania infantum): a clinicopathological study of 26 cases
    T Rallis
    Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki, Stavrou Voutyra 11, GR 54627, Thessaloniki, Greece
    J Comp Pathol 132:145-52. 2005
    ....
  72. ncbi Hepatic (64)Cu excretion in Dobermanns with subclinical hepatitis
    Paul J J Mandigers
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University Utrecht, Yalelaan 108, 3584 CM Utrecht, The Netherlands
    Res Vet Sci 83:204-9. 2007
    ..The findings suggest that impaired copper excretion may play a role in the aetiology of chronic hepatitis in the Dobermann...
  73. ncbi Synthetic triglyceride containing an arachidonic acid branch (8A8) prevents lipopolysaccharide-induced liver injury
    Nanzhe Piao
    Department of Gastroenterology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Life Sci 85:617-24. 2009
    ....
  74. ncbi Efficacy of zinc supplementation in preventing acute hepatitis in Long-Evans Cinnamon rats
    Valentina Medici
    Section of Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padova, Italy
    Liver Int 25:888-95. 2005
    ..The effect of oral zinc (Zn) acetate treatment on the development of acute hepatitis and the biochemical parameters of Cu-induced liver damage was studied in 5-week-old LEC rats (n=52)...
  75. ncbi An outbreak of chlamydiosis in farmed Indopacific crocodiles (Crocodylus porosus)
    F W Huchzermeyer
    J S Afr Vet Assoc 79:99-100. 2008
    ..The agent appears to have been introduced with live wild-caught crocodiles, which are purchased routinely by the farm. Improved quarantine procedures and treatment with tetracycline led to a rapid reduction of losses on the farm...
  76. ncbi Copper-associated hepatopathy in a Mexican fruit bat (Artibeus jamaicensis) and establishment of a reference range for hepatic copper in bats
    M Hoenerhoff
    Diagnostic Center for Population and Animal Health, Michigan State University College of Veterinary Medicine, East Lansing, MI 48823, USA
    J Vet Diagn Invest 16:590-3. 2004
    ..Hepatic copper levels in 16 additional bats, of at least 3 different species, were measured. To the authors' knowledge, this is the first reported case of copper toxicity in a chiropteran...
  77. ncbi Modulation of intracellular machinery by beta-glycolipids is associated with alteration of NKT lipid rafts and amelioration of concanavalin-induced hepatitis
    Gadi Lalazar
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Mol Immunol 45:3517-25. 2008
    ..The integrity of lipid rafts in cell membranes is important for signal transduction...
  78. ncbi Eosinophilic granulomatous gastroenterocolitis and hepatitis in a 1-year-old male Siberian Husky
    G D Brellou
    Department of Pathology, School of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Vet Pathol 43:1022-5. 2006
    ..On the basis of the findings, it is concluded that the disease in this dog represents an unusual manifestation of chronic idiopathic inflammatory bowel disease...
  79. ncbi [Role of splenin and its active factor in regulating liver monooxygenase system in experimental immunodeficiency and hepatosohepatitis]
    B V Oliĭnyk
    Komisarenko Institute of Endocrinology and Metabolism, AMS of Ukraine, Kyiv
    Ukr Biokhim Zh 73:95-9. 2001
    ..Under the NFS action the effect in activity of the last is caused by the factor influence on the reparative processes in the liver...
  80. ncbi Time course profile and cell-type-specific production of monokine induced by interferon-gamma in Concanavalin A-induced hepatic injury in mice: comparative study with interferon-inducible protein-10
    Y Itoh
    Third Dept of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Scand J Gastroenterol 36:1344-51. 2001
    ....
  81. ncbi Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism
    K Adachi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Science, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Immunol 167:5928-34. 2001
    ..berghei infection of mice induces activation of the TLR-MyD88 signaling pathway which results in IL-12 production and activation of the perforin-dependent cytotoxic activities of MHC-unrestricted hepatic lymphocytes...
  82. ncbi Three for the price of one knockout--a mouse model of a congenital peroxisomal disorder, steatohepatitis, and hepatocarcinogenesis
    N M Bass
    Department of Medicine University of California, San Francisco San Francisco, CA, USA
    Hepatology 29:606-8. 1999
  83. ncbi Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system
    Hongyan Dong
    Department of Molecular Preventive Medicine and CREST, School of Medicine, The University of Tokyo, Japan
    Biochem Biophys Res Commun 298:675-86. 2002
    ..Taken together this study has shown the systemic and comprehensive gene expression profile during FHF and may contribute to better understanding of the mechanism of FHF...
  84. pmc Carboxypeptidase D is an avian hepatitis B virus receptor
    S Tong
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Virol 73:8696-702. 1999
    The receptor molecules for human and animal hepatitis B viruses have not been defined...
  85. ncbi Cross-reactivity of human and bovine antibodies in striped dolphin paraffin wax-embedded tissues
    J R Jaber
    Departamento de Morfologia, Facultad de Veterinaria de Las Palmas de Gran Canaria, Canaria, Spain
    Vet Immunol Immunopathol 96:65-72. 2003
    ..This result suggests that those inflammatory infiltrates are highly organised to enhance antigen presentation to B and T cells...
  86. ncbi Long-term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 mice
    M T Whary
    Massachusetts Institute of Technology, Cambridge 02139, USA
    Comp Med 51:413-7. 2001
    ..hepaticus in the cecum, compared with those of hepatitis-resistant C57BL/6 mice. Host responses of A/JCr mice that limit cecal colonization with H. hepaticus may have important roles in the pathogenesis of hepatic lesions...
  87. ncbi Copper increases in both plasma and red blood cells at the onset of acute hepatitis in LEC rats
    K T Suzuki
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Res Commun Mol Pathol Pharmacol 103:189-94. 1999
    ..The source of the Cu increase in the RBCs was discussed, and it was assumed that the so-called free Cu ions that leak from the damaged hepatocytes are bound to albumin and/or taken up by the RBCs...
  88. ncbi Morbidity-mortality factors and survival of an urban coyote population in Arizona
    M Grinder
    Wildlife and Fisheries Science Program, School of Renewable Natural Resources, The University of Arizona, Tucson 85721, USA
    J Wildl Dis 37:312-7. 2001
    ..Coyotes in Tucson appear to be exposed to the viral, bacterial, and parasitic infections common in many coyote populations, but humans are the major source of mortality...
  89. ncbi Detection of infectious hepatitis A virus in blood factor concentrates by experimental infection of the New World primate Saguinus fuscicollis
    W Bodemer
    Department of Virology and Immunology, German Primate Centre, Gottingen, Germany
    Blood Coagul Fibrinolysis 6:S32-5. 1995
    ..This paper gives details of the in vivo detection of hepatitis A virus in S. fuscicolis, and the method is used to show that a blood factor VIII preparation, suspected of being contaminated with hepatitis A, did not contain the virus...
  90. ncbi Canine chronic liver disease: where are we now? Four pointers for future research
    Jan Rothuizen
    Vet J 167:219. 2004
  91. ncbi [Pathogenesis of spontaneous hepatitis in an inbred strain of LEC (Long Evans cinnamon) rats]
    T Namieno
    Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo Japan
    Nihon Geka Gakkai Zasshi 90:705-11. 1989
    ..From these results, we speculate that the involvement of hepatitis virus is not likely, but that a genetic mutation might cause low level of IgG and be also correlated with development of hepatitis...
  92. ncbi LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock
    A Mignon
    INSERM U 129 ICGM INSERM U 380 ICGM Service d Anatomopathologie, Hopital du Kremlin Bicêtre INSERM U 294, Faculte Xavier Bichat, Paris, France
    Am J Respir Crit Care Med 159:1308-15. 1999
    ..These results provide evidence that inhibitors of the ICE caspase family can prevent or even overcome the ongoing hepatic injury induced by TNF-alpha during sepsis, ischemia-reperfusion, or severe hepatitis...
  93. ncbi Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction
    Y Habu
    Department of Immunology and Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Clin Exp Med 7:30-8. 2007
    ..These results confirm the critical role that Vbeta8(+)NKT cells play in both liver and multi-organ injury...
  94. ncbi Protective effect of baicalin against lipopolysaccharide/D-galactosamine-induced liver injury in mice by up-regulation of heme oxygenase-1
    Jing yuan Wan
    Department of Pharmacology, Chongqing Medical University, Chongqing 400016, PR China
    Eur J Pharmacol 587:302-8. 2008
    ..a traditional anti-inflammatory drug, has been found to protect against liver injury in several experimental animal hepatitis models; however, the mechanisms underlying the hepatoprotective properties of baicalin are poorly understood...
  95. ncbi Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells
    Yunhua Mei
    Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Immunol Lett 110:29-35. 2007
    ..Such CIH-suppression is dose- and frequency-dependent. The suppressive effect was associated with inhibition of several major inflammatory mediators, pro-inflammatory cytokines and chemokines...
  96. ncbi An iron-deficient diet stimulates the onset of the hepatitis due to hepatic copper deposition in the Long-Evans Cinnamon (LEC) rat
    N Sugawara
    Department of Public Health, School of Medicine, Sapporo Medical University, Sapporo 060 8556, Japan
    Arch Toxicol 73:353-8. 1999
    ..Our results indicate that an Fe-deficient diet enhances the deposition of hepatic Cu due to increased absorption of Cu from the gastrointestinal tract. This deposition stimulated the onset of hepatitis...
  97. ncbi Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis
    Takehiro Torisu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Hepatology 47:1644-54. 2008
    ..These data indicate that SOCS1 is important to the prevention of hepatocyte apoptosis induced by Fas and TNF-alpha. In contrast, SOCS1 overexpression in the liver by adenoviral gene transfer prevented ConA-induced liver injury...
  98. ncbi Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model
    Yoshihiro Kamada
    Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2 2, K1, Yamada oka, Suita, Osaka 565 0871, Japan
    J Hepatol 47:556-64. 2007
    ..The aim of this study was to examine the effects of adiponectin on the progression of NASH to cirrhosis and tumor formation using adiponectin-knockout (KO) mice...
  99. ncbi NOD2: a potential target for regulating liver injury
    Mathilde Body-Malapel
    INSERM U795, Lille, France
    Lab Invest 88:318-27. 2008
    ..Taken together, our results indicate that NOD2 may represent a new therapeutic target in liver diseases...
  100. ncbi A critical role for antigen-specific Th1 cells in acute liver injury in mice
    T Nishimura
    Section of Genetic Engineering, Research Center for Genetic Engineering and Cell Transplantation, Department of Immunology, Tokai University School of Medicine, Isehara, Japan
    J Immunol 162:6503-9. 1999
    ..The Fas/Fas ligand independency was also demonstrated using Fas-deficient lpr mice. These findings indicate that Th1 cells are the major effector cells in acute liver injury...
  101. ncbi IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation
    M Schultz
    Center for Gastrointestinal Biology and Disease, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol 276:G1461-72. 1999
    ..In contrast to other genetically engineered rodents, IL-2 -/- mice develop mild focal gastrointestinal and active portal tract inflammation in the absence of viable bacteria...

Research Grants6

  1. Mechanisms of liver disease in a mouse model of AIH
    JAMES GORHAM; Fiscal Year: 2006
    ..The final aim is to analyze the genetics, mechanisms, and specificity of hepatic BALB/c-TGF-b1(-/-) effector cytotoxic T lymphocytes. ..
  2. TUMOR NECROSIS FACTOR INVOLVEMENT IN FUMONISIN TOXICITY
    RAGHUBIR SHARMA; Fiscal Year: 2001
    ..Results will help in defining the mechanism(s) of fumonisin toxicity, causes of species-specificity, and provide a better appraisal of risk in humans, including modification of fumonisin response by gram-negative infections. ..
  3. A novel inbred mouse model of autoimmune hepatitis
    JAMES GORHAM; Fiscal Year: 2002
    ..The proposal seeks to understand mechanisms that regulate the development of inflammation in the liver, so as to gain insights into the pathogenic mechanisms of AIH and other hepatic inflammatory diseases. ..
  4. Genetic Linkage Analysis of Liver Disease in Mice
    JAMES GORHAM; Fiscal Year: 2006
    ..This will have important implications for understanding the genetic basis of autoimmune hepatitis, and of hepatocellular damage in the settings of HCV infection. ..
  5. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2007
    ..Our studies will provide valuable preclinical information for eventual applications of cell therapy in people. ..
  6. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2008
    ..Completion of our studies will generate new knowledge in liver repopulation and cell and gene therapy mechanisms. This will lead to more effective liver-directed cell and gene therapy in people. ..