fetal growth retardation

Summary

Summary: The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.

Top Publications

  1. ncbi Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
  2. ncbi Socio-economic disparities in pregnancy outcome: why do the poor fare so poorly?
    M S Kramer
    Department of Pediatrics, McGill University, Canada
    Paediatr Perinat Epidemiol 14:194-210. 2000
  3. ncbi Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction
    A A Baschat
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Ultrasound Obstet Gynecol 37:501-14. 2011
  4. ncbi Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management
    Francesc Figueras
    Department of Maternal Fetal Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Am J Obstet Gynecol 204:288-300. 2011
  5. ncbi Metabolomics in newborns with intrauterine growth retardation (IUGR): urine reveals markers of metabolic syndrome
    Angelica Dessì
    Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Italy
    J Matern Fetal Neonatal Med 24:35-9. 2011
  6. ncbi The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study)
    Eleni Papadopoulou
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Eur J Nutr 52:327-36. 2013
  7. ncbi Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep
    J A Owens
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Am J Physiol Endocrinol Metab 292:E1879-89. 2007
  8. ncbi Stillbirths: the way forward in high-income countries
    Vicki Flenady
    Mater Medical Research Institute, South Brisbane, QLD, Australia
    Lancet 377:1703-17. 2011
  9. ncbi Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Apoptosis 16:135-44. 2011
  10. ncbi Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity
    Janna L Morrison
    Sansom Institute of Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia
    Pediatr Nephrol 25:669-77. 2010

Research Grants

  1. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
  2. Preeclampsia and Autoimmunity
    Rodney E Kellems; Fiscal Year: 2012
  3. HYPOTHALAMIC NEURONAL SENSITIVITY IN PREGNANT RATS
    DORANNA CHRISTENSON; Fiscal Year: 1990
  4. FETAL OXYGENATION AND GROWTH DURING MATERNAL ANEMIA
    DANIEL EDELSTONE; Fiscal Year: 1990
  5. FOLATE-RESPONSIVE DYSGENESIS
    ASOK ANTONY; Fiscal Year: 2004
  6. PRENATAL AND CHILDHOOD EXPOSURES AND AGE AT MENARCHE
    Gayle Windham; Fiscal Year: 2001
  7. GENETIC RISK FACTORS OF PREECLAMPSIA AMONG PERUVIAN WOME
    Michelle Williams; Fiscal Year: 2002
  8. NUTRITION, INSULIN-LIKE GROWTH FACTORS AND FETAL GROWTH
    Marsha Davenport; Fiscal Year: 1990
  9. PLAC1 in Placental Development
    Michael Fant; Fiscal Year: 2007
  10. The Role of PLAC1 in Placental Growth
    Michael Fant; Fiscal Year: 2003

Detail Information

Publications310 found, 100 shown here

  1. ncbi Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
    ..e., the placental bed...
  2. ncbi Socio-economic disparities in pregnancy outcome: why do the poor fare so poorly?
    M S Kramer
    Department of Pediatrics, McGill University, Canada
    Paediatr Perinat Epidemiol 14:194-210. 2000
    ....
  3. ncbi Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction
    A A Baschat
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Ultrasound Obstet Gynecol 37:501-14. 2011
    ..In late-onset FGR further research needs to establish benefits of perinatal intervention, as the pattern of vulnerability and effects of fetal deterioration appear to differ in the third trimester...
  4. ncbi Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management
    Francesc Figueras
    Department of Maternal Fetal Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Am J Obstet Gynecol 204:288-300. 2011
    ..Appropriate protocols based on available evidence as well as individualized clinical assessment are essential to ensure good management and timely delivery...
  5. ncbi Metabolomics in newborns with intrauterine growth retardation (IUGR): urine reveals markers of metabolic syndrome
    Angelica Dessì
    Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Italy
    J Matern Fetal Neonatal Med 24:35-9. 2011
    ..The metabolomic analysis showed different urine metabolic profiles between neonates with IUGR and controls and made it possible to identify the molecules responsible for such differences...
  6. ncbi The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study)
    Eleni Papadopoulou
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Eur J Nutr 52:327-36. 2013
    ....
  7. ncbi Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep
    J A Owens
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Am J Physiol Endocrinol Metab 292:E1879-89. 2007
    ..These sex differences in the onset and extent of adverse metabolic consequences after prenatal restraint in the sheep are consistent with observations in humans...
  8. ncbi Stillbirths: the way forward in high-income countries
    Vicki Flenady
    Mater Medical Research Institute, South Brisbane, QLD, Australia
    Lancet 377:1703-17. 2011
    ..Identification of ways to reduce maternal overweight and obesity is a high priority for high-income countries...
  9. ncbi Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Apoptosis 16:135-44. 2011
    ..These observations provide further insight into the potential pathogenesis of IUGR. Further research is required to elicit the role and interactions of p53 and its place in the pathogenesis of IUGR...
  10. ncbi Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity
    Janna L Morrison
    Sansom Institute of Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia
    Pediatr Nephrol 25:669-77. 2010
    ....
  11. ncbi The sick placenta-the role of malaria
    B J Brabin
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Placenta 25:359-78. 2004
    ..These statistics and our limited understanding of its pathogenesis suggest the research priorities on this subject...
  12. ncbi Adult consequences of fetal growth restriction
    David J P Barker
    Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Clin Obstet Gynecol 49:270-83. 2006
    ..Cardiovascular disease and type 2 diabetes arise through a series of interactions between environmental influences and the pathways of development that precede them...
  13. pmc Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis
    Jeltsje S Cnossen
    Department of General Practice, Academic Medical Center, Amsterdam, The Netherlands
    CMAJ 178:701-11. 2008
    ..We investigated the predictive accuracy of all uterine artery Doppler indices for both conditions in the first and second trimesters...
  14. ncbi Insulin resistance early in adulthood in subjects born with intrauterine growth retardation
    D Jaquet
    U 457, INSERM, hôpital R Debré, Paris, France
    J Clin Endocrinol Metab 85:1401-6. 2000
    ..Low glucose uptake is associated with a lesser degree of FFA suppression in adipose tissue, which suggests a role of adipose tissue at an early stage of insulin resistance in these subjects...
  15. ncbi The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction
    Bérengère Coupé
    Institut National de la Recherche Agronomique, UMR 1280 Physiologie des Adaptations Nutritionnelles, Universite de Nantes, Nantes, France
    Am J Physiol Regul Integr Comp Physiol 297:R813-24. 2009
    ..Additionally, catch-up growth immediately after early malnutrition could be a key point for the programming of postprandial hyperleptinemia...
  16. pmc Intrauterine growth restriction, human placental development and trophoblast cell death
    Christina M Scifres
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus Box 8064, 4566 Scott Avenue, St Louis, MO 63141, USA
    J Physiol 587:3453-8. 2009
    ..We predict that a better understanding of placental dysfunction in IUGR will lead to targeted therapeutic options for this important clinical condition...
  17. ncbi Metabolomic analysis reveals differences in umbilical vein plasma metabolites between normal and growth-restricted fetal pigs during late gestation
    Gang Lin
    China AgriculturalUniversity, Beijing, China
    J Nutr 142:990-8. 2012
    ....
  18. ncbi Is high consumption of fatty fish during pregnancy a risk factor for fetal growth retardation? A study of 44,824 Danish pregnant women
    Th I Halldorsson
    Maternal Nutrition Group, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Am J Epidemiol 166:687-96. 2007
    ..These results indicate that consumption of fatty fish, a known route of exposure to persistent organic pollutants, could be associated with reduced fetal growth...
  19. ncbi Cognitive function after intrauterine growth restriction and very preterm birth
    Eva Morsing
    Department of Pediatrics, Lund University, Lund, Sweden
    Pediatrics 127:e874-82. 2011
    ..To evaluate the effects of intrauterine growth restriction (IUGR) with absent or reversed end-diastolic blood flow in the umbilical artery and very preterm birth on cognitive outcome at 5 to 8 years of age...
  20. pmc Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1
    Jun H Park
    Department of Pediatrics, Children s Hospital of Philadelphia, Department of Medicine, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2316-24. 2008
    ..These results provide insight into the development of type 2 diabetes following IUGR and we believe they are the first to describe the ontogeny of chromatin remodeling in vivo from the fetus to the onset of disease in adulthood...
  21. ncbi Board-invited review: intrauterine growth retardation: implications for the animal sciences
    G Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Anim Sci 84:2316-37. 2006
    ....
  22. ncbi Altered small-world topology of structural brain networks in infants with intrauterine growth restriction and its association with later neurodevelopmental outcome
    Dafnis Batalle
    Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia ICGON, Hospital Clinic and Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Neuroimage 60:1352-66. 2012
    ....
  23. ncbi Fetal programming of coronary heart disease
    David J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:364-8. 2002
    ..Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth...
  24. ncbi The mechanisms and regulation of placental amino acid transport to the human foetus
    J K Cleal
    The Institute of Developmental Sciences, University of Southampton, Southampton, UK
    J Neuroendocrinol 20:419-26. 2008
    ..Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy...
  25. ncbi The maternal endocrine environment in the low-protein model of intra-uterine growth restriction
    D S Fernandez-Twinn
    Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QR, UK
    Br J Nutr 90:815-22. 2003
    ....
  26. ncbi Fetal growth restriction results in remodeled and less efficient hearts in children
    Fatima Crispi
    Department of Maternal Fetal Medicine Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Hospital Clinic IDIBAPS, University of Barcelona, and Centro de Investigación Biomédica en Red en Enfermedades Raras, Barcelona, Spain
    Circulation 121:2427-36. 2010
    ..Our main objective was to evaluate the alternative hypothesis that FGR induces primary cardiac changes that persist into childhood...
  27. ncbi Maternal inflammation, growth retardation, and preterm birth: insights into adult cardiovascular disease
    Lynette K Rogers
    The Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Life Sci 89:417-21. 2011
    ....
  28. ncbi Circulating thyroid hormone concentrations and placental thyroid hormone receptor expression in normal human pregnancy and pregnancy complicated by intrauterine growth restriction (IUGR)
    M D Kilby
    Department of Fetal Medicine, University of Birmingham, Edgbaston, United Kingdom
    J Clin Endocrinol Metab 83:2964-71. 1998
    ....
  29. ncbi Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Torrance, CA, USA
    Am J Physiol Regul Integr Comp Physiol 288:R91-6. 2005
    ..Thus the degree of newborn nutrient enhancement and timing of IUGR newborn catch-up growth may determine the programming of orexigenic hormones and offspring obesity...
  30. pmc Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction
    Hong Wa Yung
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Am J Pathol 173:451-62. 2008
    ..These findings may account for the increased microparticulate placental debris in the maternal circulation of these cases, leading to endothelial cell activation and impairing placental development...
  31. ncbi Early life origins of insulin resistance and type 2 diabetes in India and other Asian countries
    C S Yajnik
    Diabetes Unit, King Edward Memorial Hospital and Research Center, Rasta Peth, Pune 411011, India
    J Nutr 134:205-10. 2004
    ..These factors may be amenable to correction. Prevention of type 2 diabetes must begin in utero and continue throughout the life course...
  32. pmc IUGR decreases PPARγ and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation
    Lisa A Joss-Moore
    University of Utah, Division of Neonatology, Salt Lake City, UT 84108, USA
    Early Hum Dev 86:785-91. 2010
    ..These outcomes are offset by maternal DHA. We speculate that maintenance of the epigenetic milieu may be one role of PPARγ in the lung and suggests a novel benefit of maternal DHA supplementation in IUGR...
  33. ncbi Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model
    Joanna L Stanley
    Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 59:1021-8. 2012
    ..The data presented here demonstrate that Sildenafil can rescue pup growth and improve abnormal umbilical Doppler waveforms, providing support for a potential new therapeutic strategy targeting fetal growth restriction...
  34. ncbi Chronic lung disease of prematurity and intrauterine growth retardation: a population-based study
    Mithilesh K Lal
    Neonatal Unit, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, United Kingdom
    Pediatrics 111:483-7. 2003
    ..To determine the risk of chronic lung disease (CLD) in small for gestational age (SGA) preterm infants in comparison to appropriately grown and large for gestational age (LGA) infants...
  35. ncbi Risk of perinatal death in early-onset intrauterine growth restriction according to gestational age and cardiovascular Doppler indices: a multicenter study
    Monica Cruz-Lemini
    Department of Maternal Fetal Medicine Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain
    Fetal Diagn Ther 32:116-22. 2012
    ..To assess the value of gestational age and cardiovascular Doppler indices in predicting perinatal mortality in a multicenter cohort of early-onset intrauterine growth-restricted (IUGR) fetuses...
  36. ncbi Cord blood metabolomic profiling in intrauterine growth restriction
    Donata Favretto
    Department of Public Health and Environmental Medicine, Forensic Toxicology and Antidoping Unit, University of Padova, 35122 Padova, Italy
    Anal Bioanal Chem 402:1109-21. 2012
    ....
  37. pmc Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene
    Qi Fu
    University of Utah School of Medicine, Department of Pediatrics, Division of Neonatology, Salt Lake City, Utah 84158, USA
    FASEB J 23:2438-49. 2009
    ..Many changes persisted postnatally, and the postnatal effect of IUGR on the histone code was gender-specific. We conclude that IUGR modifies epigenetic characteristics of the rat hepatic IGF-1 gene along the length of the whole gene...
  38. pmc Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation
    Carl Bose
    Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Pediatrics 124:e450-8. 2009
    ..There is now increasing interest in exposures and events before delivery that predict CLD. The objective of this study was to identify current prenatal predictors of CLD...
  39. pmc Neonatal neurobehavior and diffusion MRI changes in brain reorganization due to intrauterine growth restriction in a rabbit model
    Elisenda Eixarch
    Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Hospital Clinic, Barcelona, Spain
    PLoS ONE 7:e31497. 2012
    ..The aim of the study was to describe the pattern and functional correlates of fetal brain reorganization induced by IUGR...
  40. pmc Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome
    Valerie A Arboleda
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Nat Genet 44:788-92. 2012
    ..All IMAGe-associated mutations clustered in the PCNA-binding domain of CDKN1C and resulted in loss of PCNA binding, distinguishing them from the mutations of CDKN1C that cause Beckwith-Wiedemann syndrome, an overgrowth syndrome...
  41. ncbi An experimental model of fetal growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit
    E Eixarch
    Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain eixarch clinic ub es
    Fetal Diagn Ther 26:203-11. 2009
    ..To describe an animal model of growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit...
  42. pmc Uteroplacental insufficiency increases visceral adiposity and visceral adipose PPARgamma2 expression in male rat offspring prior to the onset of obesity
    Lisa A Joss-Moore
    Division of Neonatology, University of Utah, 295 Chepeta Way, Salt Lake City, UT 84108, USA
    Early Hum Dev 86:179-85. 2010
    ..We speculate that the increase in visceral adiposity may contribute to the metabolic morbidities experienced by this population...
  43. ncbi Impact of maternal malaria and under-nutrition on intrauterine growth restriction: a prospective ultrasound study in Democratic Republic of Congo
    S H Landis
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Epidemiol Infect 137:294-304. 2009
    ..5, 95% CI 0.3-0.7). The interaction observed between malaria and under-nutrition suggests that antenatal programmes in malaria endemic areas should incorporate nutritional screening and supplementation in addition to IPTp...
  44. pmc Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted
    Vernon W Dolinsky
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    Diabetes 60:2274-84. 2011
    ..Since resveratrol (Resv), the polyphenol produced by plants, exerts insulin-sensitizing effects, we tested whether Resv could prevent deleterious metabolic effects of being born IUGR...
  45. ncbi Intrauterine growth retardation (IUGR): epidemiology and etiology
    Agustín Romo
    Fetal Medicine Unit, Miguel Servet University Children s Hospital, Zaragoza, Spain
    Pediatr Endocrinol Rev 6:332-6. 2009
    ....
  46. pmc The levels of hypoxia-regulated microRNAs in plasma of pregnant women with fetal growth restriction
    J F Mouillet
    Magee Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Placenta 31:781-4. 2010
    ....
  47. ncbi Malaria in pregnancy: small babies, big problem
    Alexandra J Umbers
    Department of Medicine Royal Melbourne Hospital, The University of Melbourne, Post Office Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Trends Parasitol 27:168-75. 2011
    ..Together, these strategies aim to decrease the burden of FGR associated with malaria in pregnancy...
  48. ncbi Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
    ..This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth...
  49. ncbi Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-year prospective study
    Yael Leitner
    Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Israel
    J Child Neurol 22:580-7. 2007
    ..The best perinatal parameter predictive of neurodevelopment and IQ was the Cephalization Index (P < .001). Somatic catch-up growth at age 2 and at age 9 to 10 correlated with favorable outcome at 9 to 10 years of age...
  50. ncbi Perinatal outcome and later implications of intrauterine growth restriction
    Eugenia K Pallotto
    Children s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, Kansas City, Missouri 64108, USA
    Clin Obstet Gynecol 49:257-69. 2006
    ..Morbidities associated with preterm delivery appear to be additive to those associated with fetal growth restriction so IUGR, preterm infants may be at great risk for poor neurodevelopmental outcome...
  51. ncbi Nutritional programming affects hypothalamic organization and early response to leptin
    Bérengère Coupé
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1280 Physiologie des Adaptations Nutritionnelles, Universite de Nantes, Nantes, France
    Endocrinology 151:702-13. 2010
    ....
  52. ncbi Intrauterine growth restriction affects the preterm infant's hippocampus
    Gregory A Lodygensky
    Department of Pediatrics, Washington University, St Louis, Missouri 63110, USA
    Pediatr Res 63:438-43. 2008
    ..We conclude that hippocampal development in IUGR is altered and might result from a combination of maternal corticosteroid hormone exposure, hypoxemia, and micronutrient deficiency...
  53. pmc Primary cortical folding in the human newborn: an early marker of later functional development
    J Dubois
    Department of Pediatrics, Division of Development and Growth, Geneva University Hospitals, 6 Rue Willy Donze, 1211 Geneva, Switzerland
    Brain 131:2028-41. 2008
    ....
  54. pmc Human trophoblast invasion and spiral artery transformation: the role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction
    F Lyall
    Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, United Kingdom
    Am J Pathol 158:1713-21. 2001
    ..These findings do not support a role for PECAM-1 in normal invasion or in the pathophysiology of preeclampsia or FGR...
  55. ncbi Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression
    Roni Levy
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Obstet Gynecol 186:1056-61. 2002
    ....
  56. ncbi Intrauterine growth retardation leads to the development of type 2 diabetes in the rat
    R A Simmons
    Division of Neonatology, Department of Pediatrics, University of Pennsylvania and Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Diabetes 50:2279-86. 2001
    ..05). The data presented here support the hypothesis that an abnormal intrauterine milieu can induce permanent changes in glucose homeostasis after birth and lead to type 2 diabetes in adulthood...
  57. ncbi Methods of fetal movement counting and the detection of fetal compromise
    A E P Heazell
    Division of Human Development, Maternal and Fetal Health Research Centre, St Mary s Hospital, University of Manchester, UK
    J Obstet Gynaecol 28:147-54. 2008
    ..Further investigation is required to determine an effective method of identifying patients with reduced fetal movements and to determine the best subsequent management...
  58. ncbi The placenta in pre-eclampsia and intrauterine growth restriction
    D J Roberts
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Pathol 61:1254-60. 2008
    ..Evaluation of obstetric pathology in such pregnancies should be an integral part of clinical care. This review will highlight the placental findings in IUGR and PET...
  59. ncbi Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction
    Cristina Borradori Tolsa
    Department of Pediatrics, University Children s Hospital, 1211 Geneva, Swizerland
    Pediatr Res 56:132-8. 2004
    ..These findings may provide insight into the structural-functional correlate for the developmental deficits associated with IUGR...
  60. ncbi Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat
    S E Pinney
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine Philadelphia, Philadelphia, PA, USA
    Diabetologia 54:2606-14. 2011
    ..Exendin-4 (Ex-4), a long-acting glucagon-like peptide-1 (GLP-1) analogue, given in the newborn period increases Pdx1 expression and prevents the development of diabetes in the IUGR rat...
  61. ncbi Risk factors and outcomes associated with first-trimester fetal growth restriction
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 303:527-34. 2010
    ..Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known...
  62. ncbi Intrauterine growth restriction
    Robert Resnik
    University of California, San Diego School of Medicine, La Jolla, California 92093 0621, USA
    Obstet Gynecol 99:490-6. 2002
    ..Ultrasound evaluation of fetal growth, behavior, and measurement of impedance to blood flow in fetal arterial and venous vessels form the cornerstone of evaluation of fetal condition and decision making...
  63. ncbi Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats
    X Ke
    Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84158, USA
    Physiol Genomics 25:16-28. 2006
    ..Despite these differences, caloric, fat, and protein content were similar in breast milk from Con and IUGR dams. We conclude that IUGR results in postnatal changes in cerebral chromatin structure and that these changes are sex specific...
  64. ncbi Fetal growth restriction
    Jena Miller
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland, Baltimore, MD 21201, USA
    Semin Perinatol 32:274-80. 2008
    ..Choosing appropriate monitoring intervals based on anticipated disease acceleration and intervention when fetal risks exceed neonatal risks are the prevailing current management approaches...
  65. ncbi Intrauterine growth restriction and adult disease: the role of adipocytokines
    Despina D Briana
    Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
    Eur J Endocrinol 160:337-47. 2009
    ....
  66. ncbi Forced catch-up growth after fetal protein restriction alters the adipose tissue gene expression program leading to obesity in adult mice
    V V Bol
    Laboratory of Cell Biology Institute of Life Science, Universite Catholique de Louvain, Place Croix du Sud 5, 1348 Louvain la Neuve, Belgium
    Am J Physiol Regul Integr Comp Physiol 297:R291-9. 2009
    ....
  67. pmc The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome
    J Dejmek
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
    Environ Health Perspect 108:1159-64. 2000
    ..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...
  68. ncbi Current concepts in intrauterine growth restriction
    Dara Brodsky
    Beth Israel Deaconess Medical Center and Children s Hospital, Harvard Medical School, Department of Newborn Medicine, Boston, MA 02215, USA
    J Intensive Care Med 19:307-19. 2004
    ..Future research is necessary to establish effective preventive, diagnostic, and therapeutic strategies for IUGR, perhaps affecting the health of future generations...
  69. ncbi Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction
    D Goswami
    Department of Obstetrics and Gynaecology, University of British Columbia, 4500 Oak Street, Vancouver BC V6H 3N1, Canada
    Placenta 27:56-61. 2006
    ..Similar placental pathology occurs in some cases of normotensive intrauterine growth restriction (nIUGR), but in the absence of maternal disease...
  70. pmc Constitutional mutations in RTEL1 cause severe dyskeratosis congenita
    Amanda J Walne
    Centre for Paediatrics, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Barts and The London Children s Hospital, London, UK
    Am J Hum Genet 92:448-53. 2013
    ..They also demonstrate the severe multisystem consequences of its dysfunction...
  71. pmc The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes
    Stephanie R Thorn
    University of Colorado School of Medicine, Aurora, Colorado, USA
    Semin Reprod Med 29:225-36. 2011
    ..Such adaptations, if persistent, also have the potential in later life to promote nutrient uptake and storage, which directly lead to complications of obesity, insulin resistance, reduced insulin production, and type 2 diabetes...
  72. ncbi Differential effects of intrauterine growth restriction on brain structure and development in preterm infants: a magnetic resonance imaging study
    Nelly Padilla
    Department of Maternal Fetal Medicine, Hospital Clinic, Universidad de Barcelona, Calle Sabino de Arana 1, 08028, Barcelona, Spain
    Brain Res 1382:98-108. 2011
    ..These data suggest that the IUGR induces a distinct brain pattern of structural changes that persist at 1 year of life and are associated with specific developmental difficulties...
  73. ncbi Animal models for small for gestational age and fetal programming of adult disease
    Patricia M Vuguin
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Horm Res 68:113-23. 2007
    b>Fetal growth retardation is a fetal adaptation in response to inadequate supply of oxygen and/or nutrients...
  74. pmc Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis
    Bérengère Coupé
    UMR 1280 Physiologie des Adaptations Nutritionnelles, Université de Nantes Atlantique, Nantes, France
    PLoS ONE 7:e30616. 2012
    ..This study reveals leptin resistance as an early marker of metabolic disorders that appears before any evidence of body weight increase in IUGR rats but whose mechanisms could depend of nutritional environment of the perinatal period...
  75. ncbi Placental pathology in fetal growth restriction
    Natalija Vedmedovska
    Department of Obstetrics and Gynaecology, Riga Stradins University, Riga, Latvia
    Eur J Obstet Gynecol Reprod Biol 155:36-40. 2011
    ....
  76. pmc Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet
    Nina Jansson
    Perinatal Center, Institute of Neuroscience and Physiology, Goteborg University, Sweden
    J Physiol 576:935-46. 2006
    ..Reduced maternal levels of insulin, leptin and IGF-1 may link maternal protein malnutrition to reduced fetal growth by down-regulation of key placental amino acid transporters...
  77. ncbi Serial plotting on customised fundal height charts results in doubling of the antenatal detection of small for gestational age fetuses in nulliparous women
    Alphonse Roex
    Department of Obstetrics and Gynaecology, Lyell McEwin Hospital, The University of Adelaide, South Australia, Australia
    Aust N Z J Obstet Gynaecol 52:78-82. 2012
    ..The antenatal detection of fetal growth restriction is a focus point of antenatal care. If detected fetal demise may be prevented and perinatal complications could be managed more appropriately...
  78. ncbi eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype
    Laura C Kusinski
    Maternal and Fetal Health Research Centre, School of Biomedicine, Manchester Academic Health Science Centre, The University of Manchester, St Mary s Hospital, Manchester, UK
    Am J Physiol Regul Integr Comp Physiol 303:R86-93. 2012
    ..We further postulate that this mouse model demonstrates "uteroplacental hypoxia," providing a new framework for understanding the etiology of FGR in human pregnancy...
  79. ncbi Socioeconomic and maternal determinants of small-for-gestational age births: patterns of increasing disparity
    John R Beard
    New York Academy of Medicine, Center for Urban Epidemiologic Studies, New York, NY 10029, USA
    Acta Obstet Gynecol Scand 88:575-83. 2009
    ..To better characterize the relation between socioeconomic disadvantage and small-for-gestational age births (SGA)...
  80. ncbi Neurobehavioral outcomes in preterm, growth-restricted infants with and without prenatal advanced signs of brain-sparing
    F Figueras
    Maternal Fetal Medicine Department, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Ultrasound Obstet Gynecol 38:288-94. 2011
    ..To evaluate the neurobehavioral outcomes of preterm infants with intrauterine growth restriction (IUGR), with and without prenatal advanced brain-sparing...
  81. ncbi Role of oxidative stress in intrauterine growth restriction
    Aydan Biri
    Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey
    Gynecol Obstet Invest 64:187-92. 2007
    ..The objectives of this study were to determine the role of oxidative stress in intrauterine growth restriction (IUGR) and to investigate the possible molecular mechanism(s) leading to oxidant stress in IUGR...
  82. ncbi Hypoxia-induced intrauterine growth retardation: effects on pulmonary development and surfactant protein transcription
    L Gortner
    Department of Pediatrics and Neonatology, University of Saarland, Homburg Saar, Germany
    Biol Neonate 88:129-35. 2005
    ..In order to investigate the effect of IUGR on pulmonary development, an easily reproducible animal model for fetal growth restriction has been established using hypoxia as a sole intervention in the last third of pregnancy...
  83. ncbi Hypospadias in males with intrauterine growth restriction due to placental insufficiency: the placental role in the embryogenesis of male external genitalia
    Yoav Yinon
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Placenta Clinic, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 152:75-83. 2010
    ..Early placental development likely influences male external genitalia formation. Careful sonographic evaluation of the genitalia is advised when early-onset placentally mediated IUGR is found...
  84. ncbi Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation
    Naonori Ishihara
    Department of Obstetrics and Gynecology, Kobe University School of Medicine, Japan
    Am J Obstet Gynecol 186:158-66. 2002
    ..This study was undertaken to determine whether preeclampsia and intrauterine growth retardation are associated with an increase in placental apoptosis...
  85. ncbi Apoptosis and its role in the trophoblast
    Berthold Huppertz
    Department of Anatomy II, University Hospital RWTH, Aachen, Germany
    Am J Obstet Gynecol 195:29-39. 2006
    ..This review summarizes recent findings on trophoblast apoptosis in normal and pathologic pregnancies...
  86. ncbi Memory functions of children born with asymmetric intrauterine growth restriction
    Ronny Geva
    The Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
    Brain Res 1117:186-94. 2006
    ..The main purpose was to study memory functions of children born with asymmetric IUGR in a large-scale cohort using a long-term prospective paradigm...
  87. ncbi Neurologic outcomes at school age in very preterm infants born with severe or mild growth restriction
    Isabelle Guellec
    INSERM, UMR 953, Epidemiological Research in Perinatal Health and Women s and Children Health, Bâtiment de Recherche, Hopital Tenon, Paris, France
    Pediatrics 127:e883-91. 2011
    ..To determine whether mild and severe growth restriction at birth among preterm infants is associated with neonatal mortality and cerebral palsy and cognitive performance at 5 years of age and school performance at 8 years of age...
  88. ncbi Community-level socioeconomic inequalities in infants with poor fetal growth in Western Australia, 1984 to 2006
    Amanda T Langridge
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    Ann Epidemiol 21:473-80. 2011
    ..This study describes social and racial inequalities in poor fetal growth in Western Australia between 1984 and 2006...
  89. ncbi Quad screen as a predictor of adverse pregnancy outcome
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Obstet Gynecol 106:260-7. 2005
    ....
  90. ncbi Fetal growth restriction: a modern approach
    Wendy L Kinzler
    aDepartment of Obstetrics, Gynecology and Reproductive Sciences, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Curr Opin Obstet Gynecol 20:125-31. 2008
    ..The ability to accurately predict, diagnose and manage these pregnancies has significant and far-reaching implications, including potential effects on long-term adult health...
  91. ncbi Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5
    Qi Fu
    University of Utah School of Medicine, Department of Pediatrics, Division of Neonatology, P O Box 581289, Salt Lake City, UT 84158, USA
    FASEB J 20:2127-9. 2006
    ....
  92. pmc Associations of seafood and elongated n-3 fatty acid intake with fetal growth and length of gestation: results from a US pregnancy cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Am J Epidemiol 160:774-83. 2004
    ..Results from this US cohort support the conclusion that seafood intake during pregnancy is associated with reduced fetal growth...
  93. ncbi Intrauterine growth restriction due to uteroplacental vascular insufficiency leads to increased hypoxia-induced cerebral apoptosis in newborn piglets
    Christopher Burke
    Centre for Perinatal Research, School of Medicine, University of Queensland, Herston, Australia
    Brain Res 1098:19-25. 2006
    ..The IUGR piglets showed a significantly greater amount of apoptosis in response to the hypoxia than the normal weight piglets, suggesting an increased vulnerability to apoptosis in the IUGR piglets...
  94. ncbi Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae
    Lin Guo
    Institute of Medical Sciences, University of Toronto, Toronto, Canada
    Dev Biol 320:79-91. 2008
    ..Of particular interest, we demonstrated also a decrease in IGF2 mRNA levels in all SGA placentae and showed that the decrease is, in most cases, independent of H19 regulation...
  95. pmc Complete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality
    Dong Hoon Lee
    Department of Molecular and Cellular Biology, City of Hope National Medical Center, Duarte, California, United States of America
    PLoS ONE 5:e12630. 2010
    ..We asked the question whether these barrier proteins protected the (ChβGI)(2) sequences from methylation in the male germ line...
  96. pmc Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Semin Reprod Med 29:237-45. 2011
    ..Thus preventive therapeutic interventions will require target-specific modalities that depend on the primary etiology...
  97. pmc Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep
    Kristen J Bubb
    Department of Physiology, Monash University, Clayton, Victoria, 3800, Australia
    J Physiol 578:871-81. 2007
    ..We conclude that late gestational IUGR alters the reactivity and mechanical wall properties of coronary arteries and cardiomyocyte maturation in fetal sheep, which could have lifelong implications for cardiovascular function...
  98. ncbi Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction
    Tal Biron-Shental
    Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel
    Am J Obstet Gynecol 202:381.e1-7. 2010
    ..The pathogenesis of preeclampsia and intrauterine growth restriction involves hypoxic stress. We aimed to assess telomere length in trophoblasts from pregnancies with those complications...
  99. pmc Is the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) effective for preterm infants with intrauterine growth restriction?
    H Als
    Department of Psychiatry, Children s Hospital Boston, Boston, MA 02115 USA
    J Perinatol 31:130-6. 2011
    ....
  100. ncbi Preliminary evidence for an impulsivity-based thrifty eating phenotype
    Patricia P Silveira
    Núcleo de Estudos da Saúde da Criança e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Pediatr Res 71:293-8. 2012
    ..Low birth weight is associated with obesity and an increased risk for metabolic/cardiovascular diseases in later life...
  101. ncbi Reduced expression of corticotropin-releasing hormone receptor type-1 alpha in human preeclamptic and growth-restricted placentas
    E Karteris
    The Sir Quinton Hazel Research Centre for Molecular Medicine, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 88:363-70. 2003
    ..These findings might suggest that changes in receptor expression may contribute toward dysregulation of the dynamic balance controlling vascular resistance...

Research Grants62

  1. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ..found in human maternal and fetal circulation, would reduce fetal IGF bioavailability and culminate in fetal growth retardation and low birth weight offspring...
  2. Preeclampsia and Autoimmunity
    Rodney E Kellems; Fiscal Year: 2012
    ..Do AT1-AAs contribute to fetal growth retardation? D. What pathophysiological consequences of AT1-AAs are independent of pregnancy? AIM II...
  3. HYPOTHALAMIC NEURONAL SENSITIVITY IN PREGNANT RATS
    DORANNA CHRISTENSON; Fiscal Year: 1990
    ..Hypertensive disorders of pregnancy, preterm labor, and fetal growth retardation are associated with hypovolemia and augmented pressor responses to A-II infusions...
  4. FETAL OXYGENATION AND GROWTH DURING MATERNAL ANEMIA
    DANIEL EDELSTONE; Fiscal Year: 1990
    ..These studies should enhance our understanding of the pathophysiology of the intrauterine hypoxia and fetal growth retardation that commonly complicate the pregnancies of chronically anemic women.
  5. FOLATE-RESPONSIVE DYSGENESIS
    ASOK ANTONY; Fiscal Year: 2004
    ..maternal folate deficiency using antisense FR will adversely affect placental proliferation and result in fetal growth retardation. These studies will use liposomes engineered to deliver antisense FR cDNA incorporated in a placenta ..
  6. PRENATAL AND CHILDHOOD EXPOSURES AND AGE AT MENARCHE
    Gayle Windham; Fiscal Year: 2001
    ..Prenatal alcohol exposure is associated with fetal growth retardation and neurologic impairment in offspring...
  7. GENETIC RISK FACTORS OF PREECLAMPSIA AMONG PERUVIAN WOME
    Michelle Williams; Fiscal Year: 2002
    ..and a leading cause of maternal mortality world-wide, is an important cause of preterm delivery, fetal growth retardation and perinatal mortality...
  8. NUTRITION, INSULIN-LIKE GROWTH FACTORS AND FETAL GROWTH
    Marsha Davenport; Fiscal Year: 1990
    Malnutrition during pregnancy causes fetal growth retardation. Somatomedin/insulin-like growth factor (Sm/IGFs) are believed to stimulate fetal growth and differentiation, and nutrition is a principal regulator of serum Sm/IGFs in ..
  9. PLAC1 in Placental Development
    Michael Fant; Fiscal Year: 2007
    ..This is strengthened by a fetal growth retardation phenotype and placental growth abnormalities associated with X chromosome deletions in the region to ..
  10. The Role of PLAC1 in Placental Growth
    Michael Fant; Fiscal Year: 2003
    ..This suggestion is strengthened by a fetal growth retardation phenotype associated with X chromosome deletions in the region to which PLAC1 maps...
  11. PRENATAL POLYDRUG EXPOSURE & CARDIOVASCULAR DEVELOPMENT
    Lena Sun; Fiscal Year: 1999
    ..of the most common drug combinations is the maternal use of cocaine and alcohol, which has been linked to fetal growth retardation, neurobehavioral sequelae and congenital structural defects...
  12. STABLE ISOTOPE METHOD TO DETERMINE BLOOD VOLUME
    Larry Moore; Fiscal Year: 1991
    ..are important for the general screening, diagnosis and treatment of problem pregnancies associated with fetal growth retardation, premature labor and maternal hypertension...
  13. MECHANISMS OF FETAL GROWTH RETARDATION
    Kenneth Clark; Fiscal Year: 1992
    The present study is designed to evaluate the mechanism(s) responsible for fetal growth retardation in response to reduced uteroplacental blood flow...
  14. GENETIC AND NONGENETIC RISK FACTORS OF PREECLAMPSIA
    Michelle Williams; Fiscal Year: 2000
    ..and a leading cause of maternal mortality world-wide, is an important cause of preterm delivery, fetal growth retardation and perinatal mortality. Pregnancies complicated by preeclampsia are associated with hyperlipidemia...
  15. A mouse model of placental insufficiency with abnormal renal medullary patterning
    Mark P de Caestecker; Fiscal Year: 2010
    ....
  16. The Epidemiology of Marine Fatty Acids and Preeclampsia
    Michelle Williams; Fiscal Year: 2006
    ..g., fetal growth retardation and preterm delivery)...
  17. Nicotine and Development of Autonomic Neurons
    Malathi Srivatsan; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Maternal tobacco consumption is well known to cause fetal growth retardation and neurobehavioral disturbances in the offspring...
  18. PLACENTA--IMPLANTATION TO DELIVERY
    Richard Miller; Fiscal Year: 2000
    ..reduction in the incidence of important gestational diseases such as premature rupture of membranes, fetal growth retardation, and pre-eclampsialpregnancy-induced hypertension...
  19. SOMATOMEDINS:MEDIATING ETHANOL-INDUCED GROWTH RETARD
    SONYA CONWAY; Fiscal Year: 1990
    ..Information derived from these studies will provide a basis for more directed analysis of the role of Sms in mediating ethanol-induced fetal growth retardation.
  20. IGFII AND PERINATAL CARBOHYDRATE METABOLISM
    Mary Lopez; Fiscal Year: 2002
    ..Defining the role of IGF-II and its effects on fetal growth will further understanding of the mechanisms and possible treatment of macrosomia and fetal growth retardation.
  21. Mechanisms by which GDM Leads to Diabetes in Offspring
    Rebecca Simmons; Fiscal Year: 2005
    ..non-F2 animals. ..
  22. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2007
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  23. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  24. Arginine and Ovine Model for Fetal Growth Restriction
    Guoyao Wu; Fiscal Year: 2007
    ..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..
  25. OXIDATIVE STRESS, ANTIOXIDANT STATUS & PREGNANCY OUTCOME
    Theresa Scholl; Fiscal Year: 2005
    ....
  26. Aberrant Ovine Pancreatic Development in IUGR Fetuses
    Sean Limesand; Fiscal Year: 2007
    ....
  27. Fetal Swallowing: Central Dipsogenic Mechanisms
    Michael Ross; Fiscal Year: 2007
    ..Furthermore, these studies represent a model to examine the development and function of neuronal pathways and mechanisms regulating fetal physiology. ..
  28. Fetal Membrane AQP Expression/Amniotic Fluid Regulation
    Michael Ross; Fiscal Year: 2004
    ..Our objective is to determine the regulatory mechanisms of fetal membrane AQP expression and delineate the role of AQPs in AF homeostasis. ..
  29. PREVENTION AND TREATMENT OF HUMAN OLIGOHYDRAMNIOS
    Michael Ross; Fiscal Year: 2001
    ..e., failure to reset osmolality threshold). This proposal will aid in the development of markers of prediction and therapeutic approaches to the prevention and treatment of human oligohydramnios. ..
  30. LEPTIN & NEUROPEPTIDE-Y ALTERS FETAL SWALLOWING ACTIVITY
    Michael Ross; Fiscal Year: 2002
    ..In addition, these studies represent a model to examine the development and function of neuronal pathways and mechanisms which regulate fetal physiology. ..
  31. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..The goal of this project is to determine critical efficacy and fetal safety issues central to maternal DDAVP treatment, prior to widespread clinical use in human pregnancies with oligohydramnios. ..
  32. Fetal Velocimetry & Amino Acid Transport in Pregnancy
    FREDERICK BATTAGLIA; Fiscal Year: 2007
    ..These studies will establish important links between blood flow changes in the fetus and nutrient delivery to the fetus. ..
  33. Perinatal Risk of Asthma in Infants of Asthmatic Mothers
    Michael Bracken; Fiscal Year: 2007
    ..Identification of pregnancy and neonatal risk factors for infant asthma may offer opportunities for early prevention. ..
  34. Clinically enhanced multi-purpose administrative dataset for comparative effectiv
    Hamisu Salihu; Fiscal Year: 2010
    ....
  35. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
    ..abstract_text> ..
  36. Does Early Experience Improve Preterm Neurodevelopment?
    Heidelise Als; Fiscal Year: 2010
    ..The expected reduction in learning and school failure for the increasing numbers of preterm-born children in the nation's schools, would give the study and the intervention, significant national public health importance., ..
  37. Bisphenol-A and the Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2008
    ..The findings will be relevant to research on fetal origin of infertility and the threat estrogenic environmental disruptors at current exposure levels pose to human health. ..
  38. Paraxanthine and Reproductive Effects of Caffeine
    Michael Bracken; Fiscal Year: 2004
    ..abstract_text> ..
  39. Preterm Fetal Growth Restriction and Developmental Care
    Heidelise Als; Fiscal Year: 2009
    ..The study will be significant in understanding ways to reduce long-term functional morbidities in FGR infants, as well as in identifying opportunities for enhancing last trimester brain development. ..
  40. ET and PAF Synergism in intrauterine growth restriction
    LARRY THAETE; Fiscal Year: 2008
    ..Our goal is to assess the specific role of ET-1, as well as its interaction with PAF, in the pathophysiology of I/R-induced IUGR. ..
  41. IMPACT OF ENDOTHELIN IN INTRAUTERINE GROWTH RESTRICTION
    LARRY THAETE; Fiscal Year: 2005
    ....
  42. FETAL GLUCOSE AND AMINO ACID DEPRIVATION
    William Hay; Fiscal Year: 2005
    ..abstract_text> ..
  43. Programming of gene expression during fetal life
    S Ozanne; Fiscal Year: 2005
    ....
  44. Human Biology Association 2002 Annual Meeting
    LORNA MOORE; Fiscal Year: 2002
    ..abstract_text> ..
  45. Reproductive Consequences of Prenatal Androgenization
    Vasantha Padmanabhan; Fiscal Year: 2005
    ..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
  46. NEURODEVELOPMENT AND EXPERIENCE: BEHAVIOR, QEEG AND MRI
    Heidelise Als; Fiscal Year: 2002
    ....
  47. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
  48. Fetal pancreatic development & insulin secretion
    William Hay; Fiscal Year: 2006
    ....
  49. Inflammation and Ovarian Cancer
    Clareann Bunker; Fiscal Year: 2008
    ..In particular, NSAID use may prove to be a potentially important chemopreventative for this often-fatal disease. ..
  50. ENDOTHELIN AND INTRAUTERINE GROWTH RESTRICTION
    LARRY THAETE; Fiscal Year: 2002
    ..Cellular localization of ET, ET receptors, and NOS isoforms will be performed with immunocytochemistry. ..
  51. NEUROENDOCRINE CONTROL OF FSH
    Vasantha Padmanabhan; Fiscal Year: 2001
    ....
  52. PROGRAMMING GLUCOCORTICOID SECRETION DURING FETAL LIFE
    David Phillips; Fiscal Year: 2003
    ..g. obesity reduction). ..
  53. REGULATION OF PLACENTAL METABOLISM BY GLUCOSE SUPPLY
    William Hay; Fiscal Year: 2006
    ..These are essential studies to conduct, as IUGR, primarily caused by placental insufficiency, is an important national and international health problem affecting the fetus, neonate, child, and adult. ..
  54. Maternal Endothelial Progenitor Cells and Preeclampsia
    Carl Hubel; Fiscal Year: 2006
    ..As EPC function is modifiable, this systematic, groundbreaking study could provide clues to prevention or treatment of preeclampsia and associated later-life cardiovascular disease. [unreadable] [unreadable]..
  55. Genomic and Epigenomic Profiling by MSNP
    Benjamin Tycko; Fiscal Year: 2008
    ..Data from MSNP are expected to shed light on cancer pathogenesis and produce new and robust markers for cancer diagnosis and detection. [unreadable] [unreadable] [unreadable]..
  56. Prevention of diabetes due to growth retardation
    Doris Stoffers; Fiscal Year: 2008
    ..We have developed a model of fetal growth retardation, designated as IUGR (intrauterine growth retarded), in the rodent, induced by bilateral uterine artery ..
  57. CONGENITAL CYTOMEGALOVIRUS MODEL OF AUDITORY PATHOLOGY
    NIGEL WOOLF; Fiscal Year: 2005
    ....
  58. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Massaging Preterm Infants Enhances Growth
    Tiffany Field; Fiscal Year: 2006
    ..abstract_text> ..
  60. Effects of Maternal Diet on SNS Development in Offspring
    James Young; Fiscal Year: 2009
    ..Identifying connections among growth, SNS development and obesity offers a potential means for identifying obesity-prone individuals early in life with the ultimate objective of intervening in an effective and appropriate manner. ..