fetal growth retardation

Summary

Summary: The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.

Top Publications

  1. ncbi The sick placenta-the role of malaria
    B J Brabin
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Placenta 25:359-78. 2004
  2. ncbi Fetal programming of coronary heart disease
    David J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:364-8. 2002
  3. ncbi Socio-economic disparities in pregnancy outcome: why do the poor fare so poorly?
    M S Kramer
    Department of Pediatrics, McGill University, Canada
    Paediatr Perinat Epidemiol 14:194-210. 2000
  4. doi Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Apoptosis 16:135-44. 2011
  5. doi Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity
    Janna L Morrison
    Sansom Institute of Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia
    Pediatr Nephrol 25:669-77. 2010
  6. ncbi Adult consequences of fetal growth restriction
    David J P Barker
    Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Clin Obstet Gynecol 49:270-83. 2006
  7. pmc Intrauterine growth restriction, human placental development and trophoblast cell death
    Christina M Scifres
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus Box 8064, 4566 Scott Avenue, St Louis, MO 63141, USA
    J Physiol 587:3453-8. 2009
  8. ncbi Insulin resistance early in adulthood in subjects born with intrauterine growth retardation
    D Jaquet
    U 457, INSERM, hôpital R Debré, Paris, France
    J Clin Endocrinol Metab 85:1401-6. 2000
  9. doi The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction
    Bérengère Coupé
    Institut National de la Recherche Agronomique, UMR 1280 Physiologie des Adaptations Nutritionnelles, Universite de Nantes, Nantes, France
    Am J Physiol Regul Integr Comp Physiol 297:R813-24. 2009
  10. doi The mechanisms and regulation of placental amino acid transport to the human foetus
    J K Cleal
    The Institute of Developmental Sciences, University of Southampton, Southampton, UK
    J Neuroendocrinol 20:419-26. 2008

Research Grants

  1. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
  2. MATERNAL DEHYDRATION--FETAL & AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 1992
  3. THE ROLE OF PLACENTAL LACTOGEN IN FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 1990
  4. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2003
  5. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2006
  6. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2007
  7. FOLATE-RESPONSIVE DYSGENESIS
    ASOK ANTONY; Fiscal Year: 2004
  8. The Role of PLAC1 in Placental Growth
    Michael Fant; Fiscal Year: 2003
  9. PLAC1 in Placental Development
    Michael Fant; Fiscal Year: 2007
  10. FETAL OXYGENATION AND PLACENTAL GAS EXCHANGE
    LAWRENCE LONGO; Fiscal Year: 1991

Detail Information

Publications269 found, 100 shown here

  1. ncbi The sick placenta-the role of malaria
    B J Brabin
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Placenta 25:359-78. 2004
    ..These statistics and our limited understanding of its pathogenesis suggest the research priorities on this subject...
  2. ncbi Fetal programming of coronary heart disease
    David J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:364-8. 2002
    ..Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth...
  3. ncbi Socio-economic disparities in pregnancy outcome: why do the poor fare so poorly?
    M S Kramer
    Department of Pediatrics, McGill University, Canada
    Paediatr Perinat Epidemiol 14:194-210. 2000
    ....
  4. doi Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Apoptosis 16:135-44. 2011
    ..These observations provide further insight into the potential pathogenesis of IUGR. Further research is required to elicit the role and interactions of p53 and its place in the pathogenesis of IUGR...
  5. doi Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity
    Janna L Morrison
    Sansom Institute of Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia
    Pediatr Nephrol 25:669-77. 2010
    ....
  6. ncbi Adult consequences of fetal growth restriction
    David J P Barker
    Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Clin Obstet Gynecol 49:270-83. 2006
    ..Cardiovascular disease and type 2 diabetes arise through a series of interactions between environmental influences and the pathways of development that precede them...
  7. pmc Intrauterine growth restriction, human placental development and trophoblast cell death
    Christina M Scifres
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus Box 8064, 4566 Scott Avenue, St Louis, MO 63141, USA
    J Physiol 587:3453-8. 2009
    ..We predict that a better understanding of placental dysfunction in IUGR will lead to targeted therapeutic options for this important clinical condition...
  8. ncbi Insulin resistance early in adulthood in subjects born with intrauterine growth retardation
    D Jaquet
    U 457, INSERM, hôpital R Debré, Paris, France
    J Clin Endocrinol Metab 85:1401-6. 2000
    ..Low glucose uptake is associated with a lesser degree of FFA suppression in adipose tissue, which suggests a role of adipose tissue at an early stage of insulin resistance in these subjects...
  9. doi The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction
    Bérengère Coupé
    Institut National de la Recherche Agronomique, UMR 1280 Physiologie des Adaptations Nutritionnelles, Universite de Nantes, Nantes, France
    Am J Physiol Regul Integr Comp Physiol 297:R813-24. 2009
    ..Additionally, catch-up growth immediately after early malnutrition could be a key point for the programming of postprandial hyperleptinemia...
  10. doi The mechanisms and regulation of placental amino acid transport to the human foetus
    J K Cleal
    The Institute of Developmental Sciences, University of Southampton, Southampton, UK
    J Neuroendocrinol 20:419-26. 2008
    ..Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy...
  11. doi Maternal inflammation, growth retardation, and preterm birth: insights into adult cardiovascular disease
    Lynette K Rogers
    The Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Life Sci 89:417-21. 2011
    ....
  12. doi Fetal growth restriction results in remodeled and less efficient hearts in children
    Fatima Crispi
    Department of Maternal Fetal Medicine Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Hospital Clinic IDIBAPS, University of Barcelona, and Centro de Investigación Biomédica en Red en Enfermedades Raras, Barcelona, Spain
    Circulation 121:2427-36. 2010
    ..Our main objective was to evaluate the alternative hypothesis that FGR induces primary cardiac changes that persist into childhood...
  13. ncbi The maternal endocrine environment in the low-protein model of intra-uterine growth restriction
    D S Fernandez-Twinn
    Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QR, UK
    Br J Nutr 90:815-22. 2003
    ....
  14. doi Nutritional programming affects hypothalamic organization and early response to leptin
    Bérengère Coupé
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1280 Physiologie des Adaptations Nutritionnelles, Universite de Nantes, Nantes, France
    Endocrinology 151:702-13. 2010
    ....
  15. ncbi Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Torrance, CA, USA
    Am J Physiol Regul Integr Comp Physiol 288:R91-6. 2005
    ..Thus the degree of newborn nutrient enhancement and timing of IUGR newborn catch-up growth may determine the programming of orexigenic hormones and offspring obesity...
  16. doi Risk factors and outcomes associated with first-trimester fetal growth restriction
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 303:527-34. 2010
    ..Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known...
  17. pmc Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction
    Hong Wa Yung
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Am J Pathol 173:451-62. 2008
    ..These findings may account for the increased microparticulate placental debris in the maternal circulation of these cases, leading to endothelial cell activation and impairing placental development...
  18. ncbi Apoptosis and its role in the trophoblast
    Berthold Huppertz
    Department of Anatomy II, University Hospital RWTH, Aachen, Germany
    Am J Obstet Gynecol 195:29-39. 2006
    ..This review summarizes recent findings on trophoblast apoptosis in normal and pathologic pregnancies...
  19. ncbi Early life origins of insulin resistance and type 2 diabetes in India and other Asian countries
    C S Yajnik
    Diabetes Unit, King Edward Memorial Hospital and Research Center, Rasta Peth, Pune 411011, India
    J Nutr 134:205-10. 2004
    ..These factors may be amenable to correction. Prevention of type 2 diabetes must begin in utero and continue throughout the life course...
  20. pmc Uteroplacental insufficiency increases visceral adiposity and visceral adipose PPARgamma2 expression in male rat offspring prior to the onset of obesity
    Lisa A Joss-Moore
    Division of Neonatology, University of Utah, 295 Chepeta Way, Salt Lake City, UT 84108, USA
    Early Hum Dev 86:179-85. 2010
    ..We speculate that the increase in visceral adiposity may contribute to the metabolic morbidities experienced by this population...
  21. doi Impact of maternal malaria and under-nutrition on intrauterine growth restriction: a prospective ultrasound study in Democratic Republic of Congo
    S H Landis
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Epidemiol Infect 137:294-304. 2009
    ..5, 95% CI 0.3-0.7). The interaction observed between malaria and under-nutrition suggests that antenatal programmes in malaria endemic areas should incorporate nutritional screening and supplementation in addition to IPTp...
  22. pmc Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted
    Vernon W Dolinsky
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    Diabetes 60:2274-84. 2011
    ..Since resveratrol (Resv), the polyphenol produced by plants, exerts insulin-sensitizing effects, we tested whether Resv could prevent deleterious metabolic effects of being born IUGR...
  23. doi Malaria in pregnancy: small babies, big problem
    Alexandra J Umbers
    Department of Medicine Royal Melbourne Hospital, The University of Melbourne, Post Office Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Trends Parasitol 27:168-75. 2011
    ..Together, these strategies aim to decrease the burden of FGR associated with malaria in pregnancy...
  24. doi Intrauterine growth restriction affects the preterm infant's hippocampus
    Gregory A Lodygensky
    Department of Pediatrics, Washington University, St Louis, Missouri 63110, USA
    Pediatr Res 63:438-43. 2008
    ..We conclude that hippocampal development in IUGR is altered and might result from a combination of maternal corticosteroid hormone exposure, hypoxemia, and micronutrient deficiency...
  25. ncbi Intrauterine growth restriction
    Robert Resnik
    University of California, San Diego School of Medicine, La Jolla, California 92093 0621, USA
    Obstet Gynecol 99:490-6. 2002
    ..Ultrasound evaluation of fetal growth, behavior, and measurement of impedance to blood flow in fetal arterial and venous vessels form the cornerstone of evaluation of fetal condition and decision making...
  26. pmc Primary cortical folding in the human newborn: an early marker of later functional development
    J Dubois
    Department of Pediatrics, Division of Development and Growth, Geneva University Hospitals, 6 Rue Willy Donze, 1211 Geneva, Switzerland
    Brain 131:2028-41. 2008
    ....
  27. ncbi Intrauterine growth retardation leads to the development of type 2 diabetes in the rat
    R A Simmons
    Division of Neonatology, Department of Pediatrics, University of Pennsylvania and Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Diabetes 50:2279-86. 2001
    ..05). The data presented here support the hypothesis that an abnormal intrauterine milieu can induce permanent changes in glucose homeostasis after birth and lead to type 2 diabetes in adulthood...
  28. pmc Human trophoblast invasion and spiral artery transformation: the role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction
    F Lyall
    Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, United Kingdom
    Am J Pathol 158:1713-21. 2001
    ..These findings do not support a role for PECAM-1 in normal invasion or in the pathophysiology of preeclampsia or FGR...
  29. ncbi Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression
    Roni Levy
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Obstet Gynecol 186:1056-61. 2002
    ....
  30. doi Methods of fetal movement counting and the detection of fetal compromise
    A E P Heazell
    Division of Human Development, Maternal and Fetal Health Research Centre, St Mary s Hospital, University of Manchester, UK
    J Obstet Gynaecol 28:147-54. 2008
    ..Further investigation is required to determine an effective method of identifying patients with reduced fetal movements and to determine the best subsequent management...
  31. doi Intrauterine growth restriction and adult disease: the role of adipocytokines
    Despina D Briana
    Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
    Eur J Endocrinol 160:337-47. 2009
    ....
  32. ncbi Perinatal outcome and later implications of intrauterine growth restriction
    Eugenia K Pallotto
    Children s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, Kansas City, Missouri 64108, USA
    Clin Obstet Gynecol 49:257-69. 2006
    ..Morbidities associated with preterm delivery appear to be additive to those associated with fetal growth restriction so IUGR, preterm infants may be at great risk for poor neurodevelopmental outcome...
  33. ncbi Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
    ..This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth...
  34. pmc The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome
    J Dejmek
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
    Environ Health Perspect 108:1159-64. 2000
    ..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...
  35. doi Forced catch-up growth after fetal protein restriction alters the adipose tissue gene expression program leading to obesity in adult mice
    V V Bol
    Laboratory of Cell Biology Institute of Life Science, Universite Catholique de Louvain, Place Croix du Sud 5, 1348 Louvain la Neuve, Belgium
    Am J Physiol Regul Integr Comp Physiol 297:R291-9. 2009
    ....
  36. ncbi Current concepts in intrauterine growth restriction
    Dara Brodsky
    Beth Israel Deaconess Medical Center and Children s Hospital, Harvard Medical School, Department of Newborn Medicine, Boston, MA 02215, USA
    J Intensive Care Med 19:307-19. 2004
    ..Future research is necessary to establish effective preventive, diagnostic, and therapeutic strategies for IUGR, perhaps affecting the health of future generations...
  37. ncbi Animal models for small for gestational age and fetal programming of adult disease
    Patricia M Vuguin
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Horm Res 68:113-23. 2007
    b>Fetal growth retardation is a fetal adaptation in response to inadequate supply of oxygen and/or nutrients...
  38. doi Fetal growth restriction
    Jena Miller
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland, Baltimore, MD 21201, USA
    Semin Perinatol 32:274-80. 2008
    ..Choosing appropriate monitoring intervals based on anticipated disease acceleration and intervention when fetal risks exceed neonatal risks are the prevailing current management approaches...
  39. ncbi Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction
    D Goswami
    Department of Obstetrics and Gynaecology, University of British Columbia, 4500 Oak Street, Vancouver BC V6H 3N1, Canada
    Placenta 27:56-61. 2006
    ..Similar placental pathology occurs in some cases of normotensive intrauterine growth restriction (nIUGR), but in the absence of maternal disease...
  40. pmc Associations of seafood and elongated n-3 fatty acid intake with fetal growth and length of gestation: results from a US pregnancy cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Am J Epidemiol 160:774-83. 2004
    ..Results from this US cohort support the conclusion that seafood intake during pregnancy is associated with reduced fetal growth...
  41. ncbi Intrauterine growth restriction due to uteroplacental vascular insufficiency leads to increased hypoxia-induced cerebral apoptosis in newborn piglets
    Christopher Burke
    Centre for Perinatal Research, School of Medicine, University of Queensland, Herston, Australia
    Brain Res 1098:19-25. 2006
    ..The IUGR piglets showed a significantly greater amount of apoptosis in response to the hypoxia than the normal weight piglets, suggesting an increased vulnerability to apoptosis in the IUGR piglets...
  42. doi Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae
    Lin Guo
    Institute of Medical Sciences, University of Toronto, Toronto, Canada
    Dev Biol 320:79-91. 2008
    ..Of particular interest, we demonstrated also a decrease in IGF2 mRNA levels in all SGA placentae and showed that the decrease is, in most cases, independent of H19 regulation...
  43. pmc Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep
    Kristen J Bubb
    Department of Physiology, Monash University, Clayton, Victoria, 3800, Australia
    J Physiol 578:871-81. 2007
    ..We conclude that late gestational IUGR alters the reactivity and mechanical wall properties of coronary arteries and cardiomyocyte maturation in fetal sheep, which could have lifelong implications for cardiovascular function...
  44. ncbi Reduced expression of corticotropin-releasing hormone receptor type-1 alpha in human preeclamptic and growth-restricted placentas
    E Karteris
    The Sir Quinton Hazel Research Centre for Molecular Medicine, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 88:363-70. 2003
    ..These findings might suggest that changes in receptor expression may contribute toward dysregulation of the dynamic balance controlling vascular resistance...
  45. doi Fetal growth restriction: a modern approach
    Wendy L Kinzler
    aDepartment of Obstetrics, Gynecology and Reproductive Sciences, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Curr Opin Obstet Gynecol 20:125-31. 2008
    ..The ability to accurately predict, diagnose and manage these pregnancies has significant and far-reaching implications, including potential effects on long-term adult health...
  46. ncbi Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5
    Qi Fu
    University of Utah School of Medicine, Department of Pediatrics, Division of Neonatology, P O Box 581289, Salt Lake City, UT 84158, USA
    FASEB J 20:2127-9. 2006
    ....
  47. doi Preliminary evidence for an impulsivity-based thrifty eating phenotype
    Patricia P Silveira
    Núcleo de Estudos da Saúde da Criança e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Pediatr Res 71:293-8. 2012
    ..Low birth weight is associated with obesity and an increased risk for metabolic/cardiovascular diseases in later life...
  48. doi Is the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) effective for preterm infants with intrauterine growth restriction?
    H Als
    Department of Psychiatry, Children s Hospital Boston, Boston, MA 02115 USA
    J Perinatol 31:130-6. 2011
    ....
  49. doi Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction
    Tal Biron-Shental
    Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel
    Am J Obstet Gynecol 202:381.e1-7. 2010
    ..The pathogenesis of preeclampsia and intrauterine growth restriction involves hypoxic stress. We aimed to assess telomere length in trophoblasts from pregnancies with those complications...
  50. pmc Complete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality
    Dong Hoon Lee
    Department of Molecular and Cellular Biology, City of Hope National Medical Center, Duarte, California, United States of America
    PLoS ONE 5:e12630. 2010
    ..We asked the question whether these barrier proteins protected the (ChβGI)(2) sequences from methylation in the male germ line...
  51. pmc Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study
    Jennifer B Griffin
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, McGavran Greenberg Hall, Campus Box 7435, Chapel Hill, 27599 7435, USA
    Malar J 11:319. 2012
    ..The objective of this analysis was to examine the effect of malaria parasitaemia prior to 20 weeks' gestation on subsequent changes in uterine and umbilical artery blood flow and intrauterine growth restriction...
  52. doi Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Semin Reprod Med 29:237-45. 2011
    ..Thus preventive therapeutic interventions will require target-specific modalities that depend on the primary etiology...
  53. doi Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat
    S E Pinney
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine Philadelphia, Philadelphia, PA, USA
    Diabetologia 54:2606-14. 2011
    ..Exendin-4 (Ex-4), a long-acting glucagon-like peptide-1 (GLP-1) analogue, given in the newborn period increases Pdx1 expression and prevents the development of diabetes in the IUGR rat...
  54. doi An experimental model of fetal growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit
    E Eixarch
    Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain eixarch clinic ub es
    Fetal Diagn Ther 26:203-11. 2009
    ..To describe an animal model of growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit...
  55. pmc Fetal growth restriction is associated with accelerated telomere shortening and increased expression of cell senescence markers in the placenta
    P Davy
    John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Placenta 30:539-42. 2009
    ..01). These observations support a direct affect of reduced telomerase activity levels on the placental pathology associated with FGR...
  56. doi Activating protein-1 family of transcription factors in the human placenta complicated by preeclampsia with and without fetal growth restriction
    D Marzioni
    Department of Molecular Pathology and Innovative Therapies, Marche Polytechnic University, Via Tronto, 10 a I 60126 Ancona, Italy
    Placenta 31:919-27. 2010
    ....
  57. doi Altered small-world topology of structural brain networks in infants with intrauterine growth restriction and its association with later neurodevelopmental outcome
    Dafnis Batalle
    Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia ICGON, Hospital Clinic and Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Neuroimage 60:1352-66. 2012
    ....
  58. ncbi Nitric oxide and peroxynitrite platelet levels in women with small-for-gestational-age fetuses
    L Nanetti
    Institute of Biochemistry, Polytechnical University of Marche, Ancona, Italy
    BJOG 115:14-21. 2008
    ..Excessive ROS production may occur in pathological pregnancies, such as those complicated by small-for-gestational-age (SGA) fetuses...
  59. ncbi Histomorphology of the placenta and the placental bed of growth restricted foetuses and correlation with the Doppler velocimetries of the uterine and umbilical arteries
    R Madazli
    Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Placenta 24:510-6. 2003
    ..The most severe clinical outcomes and perinatal mortality are present when both uterine and umbilical districts are altered...
  60. pmc Umbilical cord serum cytokine levels and risks of small-for-gestational-age and preterm birth
    Gila I Neta
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA
    Am J Epidemiol 171:859-67. 2010
    ..31, 1.01). The observations regarding IFN-gamma, which is involved in the activation of adaptive immune responses and regulation of trophoblast function, suggest that IFN-gamma levels at birth may be related to fetal growth restriction...
  61. ncbi Endogenous tumor necrosis factor alpha mediates enhanced apoptosis of cultured villous trophoblasts from intrauterine growth-restricted placentae
    R T Kilani
    University of Alberta Perinatal Research Centre, Edmonton, Canada
    Reproduction 133:257-64. 2007
    ....
  62. doi Metabolomics in newborns with intrauterine growth retardation (IUGR): urine reveals markers of metabolic syndrome
    Angelica Dessì
    Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Italy
    J Matern Fetal Neonatal Med 24:35-9. 2011
    ..The metabolomic analysis showed different urine metabolic profiles between neonates with IUGR and controls and made it possible to identify the molecules responsible for such differences...
  63. doi Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management
    Francesc Figueras
    Department of Maternal Fetal Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Am J Obstet Gynecol 204:288-300. 2011
    ..Appropriate protocols based on available evidence as well as individualized clinical assessment are essential to ensure good management and timely delivery...
  64. doi Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction
    A A Baschat
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Ultrasound Obstet Gynecol 37:501-14. 2011
    ..In late-onset FGR further research needs to establish benefits of perinatal intervention, as the pattern of vulnerability and effects of fetal deterioration appear to differ in the third trimester...
  65. pmc The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signalling in skeletal muscle
    B S Muhlhausler
    Early Origins of Adult Health Research Group, Sansom Research Institute, University of South Australia, Adelaide 5001, Australia
    J Physiol 587:4199-211. 2009
    ..These data provide evidence that the origins of the accelerated growth experienced by the small baby after birth lie in the adaptive response of the growth restricted fetus to its low placental substrate supply...
  66. ncbi The impact of placental malaria on gestational age and birth weight
    C Menendez
    Unidad de Epidemiologia y Bioestadistica, Hospital Clinic, E 08036, Barcelona, Spain
    J Infect Dis 181:1740-5. 2000
    ..This study also shows that placental malaria causes prematurity even in high-transmission areas. The impact of maternal malaria on infant mortality may be greater than was thought previously...
  67. ncbi IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a review
    T Jansson
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, PO Box 670526, Cincinnati, OH 45267, USA
    Placenta 27:S91-7. 2006
    ..Preliminary evidence suggests that placental mammalian target of rapamycin, a protein kinase regulating protein translation and transcription in response to nutrient stimuli, may be involved in placental nutrient sensing...
  68. doi Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces
    Joanna L James
    Division of Basic Medical Sciences, St George s University of London, London, UK
    J Pathol 221:363-78. 2010
    ....
  69. pmc Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome
    Christian F Rueda-Clausen
    Department of Physiology, University of Alberta, Edmonton, Canada
    Diabetes 60:507-16. 2011
    ..Thus, we hypothesized that offspring born with IUGR exhibit permanent metabolic changes that make them more susceptible to HF diet-induced MetS...
  70. ncbi Experimental intrauterine growth retardation in the rat causes a reduction of pancreatic B-cell mass, which persists into adulthood
    J Styrud
    Department of Surgery, Karolinska Institute at Danderyd Hospital, Stockholm, Sweden
    Biol Neonate 88:122-8. 2005
    ....
  71. ncbi Board-invited review: intrauterine growth retardation: implications for the animal sciences
    G Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Anim Sci 84:2316-37. 2006
    ....
  72. ncbi Nutritional modulation of adolescent pregnancy outcome -- a review
    J M Wallace
    Development, Growth and Function Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK
    Placenta 27:S61-8. 2006
    ..Thus, while the underlying mechanisms differ, maternal intake at both ends of the nutritional spectrum is a powerful determinant of fetal growth in pregnant adolescents...
  73. ncbi Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep
    Mohan Manikkam
    Department of Pediatrics, University of Michigan, 300 North Ingalls Building, Room 1109 SW, Ann Arbor, MI 48109 0404, USA
    Endocrinology 145:790-8. 2004
    ..These findings support the concept that fetal growth retardation and postnatal catch-up growth, early markers of future adult diseases, can also be programmed by prenatal ..
  74. doi Intrauterine restriction (IUGR)
    Giampaolo Mandruzzato
    Department of Obstetrics and Gynecology, Istituto per l Infanzia, Burlo Garofolo, Trieste, Italy
    J Perinat Med 36:277-81. 2008
    ..Careful monitoring of the IUGR fetus during labor is crucial as the IUGR fetus can quickly decompensate once uterine contractions have started...
  75. pmc Disproportionate Intrauterine Growth Intervention Trial At Term: DIGITAT
    Kim E Boers
    Department of Obstetrics and Gynaecology, Leiden University Medical Center, The Netherlands
    BMC Pregnancy Childbirth 7:12. 2007
    ..We propose a randomised trial to compare effectiveness, costs and maternal quality of life for induction of labour versus expectant management in women with a suspected IUGR fetus at term...
  76. ncbi Thermal environment and human birth weight
    Jonathan C K Wells
    MRC Childhood Nutrition Research Centre, 30 Guilford Street, London WC1N 1EH, UK
    J Theor Biol 214:413-25. 2002
    ..These associations generate the hypothesis that low birth weight in hot environments may in part represent an adaptation to environmental heat stress...
  77. doi Growth restriction before or after birth reduces nephron number and increases blood pressure in male rats
    Mary E Wlodek
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Kidney Int 74:187-95. 2008
    ..This study also demonstrates that the early postnatal period is a critical time for nephron endowment in the rat...
  78. doi Aortic intima media thickness in fetuses and children with intrauterine growth restriction
    Erich Cosmi
    Gynecological Science and Human Reproduction, University of Padua School of Medicine, Padua, Italy
    Obstet Gynecol 114:1109-14. 2009
    ....
  79. ncbi Dendritic morphology is altered in hippocampal neurons following prenatal compromise
    Sandra Dieni
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, 3010, Victoria, Australia
    J Neurobiol 55:41-52. 2003
    ..These findings demonstrate that a chronic prenatal insult causes selective changes in the morphology of hippocampal cell dendrites and may lead to alterations in hippocampal function in the postnatal period...
  80. pmc Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia
    G J Burton
    Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Placenta 30:S43-8. 2009
    ....
  81. pmc Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth
    Darran N Tosh
    David Geffen School of Medicine at University of California Los Angeles, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1023-9. 2010
    ..Modulation of the rate of IUGR newborn catch-up growth may thus protect against IGF1 epigenetic modifications and, consequently, obesity and associated metabolic abnormalities...
  82. doi Effects of hypoxia-induced intrauterine growth restriction on cardiopulmonary structure and function during adulthood
    Christian F Rueda-Clausen
    Department of Physiology, University of Alberta, Edmonton, Canada
    Cardiovasc Res 81:713-22. 2009
    ..However, the in vivo characteristics of these models are still unknown. The main aim of this work was to evaluate, in vivo, the effects of IUGR on cardiopulmonary structure and function during adulthood...
  83. doi Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities
    Miguel N Llanos
    Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology INTA, University of Chile, Macul 5540, Casilla 138 11, Santiago, Chile
    Reprod Toxicol 27:88-92. 2009
    ....
  84. pmc Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3
    Yoav Yinon
    Department of Obstetrics and Gynecology, Mount Sinai Hospital, Samuel Lunenfeld Research Institute, 600 University Ave, Room 871C, Toronto, Ontario, Canada M5G 1X5
    Am J Pathol 172:77-85. 2008
    ..These data demonstrate that oxygen regulates the placental expression of endoglin via TGF-beta 3. Reduced placental perfusion leading to placental hypoxia might contribute to the increased expression of endoglin in IUGR pregnancies...
  85. ncbi Microarray-based identification of differentially expressed genes in hypoxic term human trophoblasts and in placental villi of pregnancies with growth restricted fetuses
    C R Roh
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus Box 8064, 4566 Scott Avenue, St Louis, MO 63110, USA
    Placenta 26:319-28. 2005
    ..The identification of hypoxic trophoblast signature transcripts may implicate new mediators in pathways underlying trophoblast hypoxic injury and adaptation...
  86. ncbi Fetal programming: causes and consequences as revealed by studies of dietary manipulation in rats -- a review
    H J McArdle
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Placenta 27:S56-60. 2006
    ..Our conclusions are that, while there may well be some common gatekeeper pathways, there is also some diversity of mechanism which may contribute to the generation of the same or similar phenotypes...
  87. pmc Innate immunity, coagulation and placenta-related adverse pregnancy outcomes
    Min Li
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Thromb Res 124:656-62. 2009
    ..In this review, we will summarize the mutual regulation between blood coagulation and innate immune systems as well as their roles in the maintenance of normal pregnancy and in the pathogenesis of adverse pregnancy outcomes...
  88. pmc Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats
    Reid F Thompson
    Departments of Genetics Computational Genetics, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    J Biol Chem 285:15111-8. 2010
    ..These results demonstrate that epigenetic dysregulation is a strong candidate for propagating the cellular memory of intrauterine events, causing changes in expression of nearby genes and long term susceptibility to type 2 diabetes...
  89. ncbi Small body size at birth and behavioural symptoms of ADHD in children aged five to six years
    J Lahti
    Department of Psychology, University of Helsinki, Finland
    J Child Psychol Psychiatry 47:1167-74. 2006
    ..However, the evidence stems from highly selected groups with birth outcomes biased towards the extreme low end of the distribution in birth weight. Whether a similar association exists among the normal range of term birth is unclear...
  90. pmc Early fetal hypoxia leads to growth restriction and myocardial thinning
    Margie Ream
    Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Regul Integr Comp Physiol 295:R583-95. 2008
    ..We propose that hypoxia compromises the fetus through myocardial hypoplasia and reduced heart rate...
  91. ncbi Glucose transport and system A activity in syncytiotrophoblast microvillous and basal plasma membranes in intrauterine growth restriction
    T Jansson
    Perinatal Center, Department of Physiology and Pharmacology, Goteborg University, Sweden
    Placenta 23:392-9. 2002
    ..The hypoglycemia present in utero in some IUGR fetuses is not caused by a decreased glucose transport capacity across the syncytiotrophoblast plasma membranes...
  92. doi Vasculogenesis and angiogenesis in the IUGR placenta
    Juan A Arroyo
    Divisions of Maternal Fetal Medicine and Basic Reproductive Biology, Department of Obstetrics and Gynecology, University of Colorado and Health Sciences Center, Aurora, CO 80045, USA
    Semin Perinatol 32:172-7. 2008
    ..Disruption in the balance of these controlling factors may explain the vascular malformations seen in pregnancies complicated by intrauterine growth restriction...
  93. doi Modeling intrauterine growth retardation in rodents: Impact on pancreas development and glucose homeostasis
    V M Schwitzgebel
    Department of Pediatrics, Geneva University Hospitals, Switzerland
    Mol Cell Endocrinol 304:78-83. 2009
    ..Here we review models that give further details about the molecular determinants of fetal and postnatal pancreatic islet development that are required to understand the consequences of fetal insults...
  94. ncbi Primary, secondary, and tertiary prevention of pre-eclampsia
    G Dekker
    University of Adelaide, Lyell McEwin Hospital, North Western Adelaide Health Service, SA, Australia
    Lancet 357:209-15. 2001
    ..Severe hypertension needs treatment. If antihypertensive is indicated, there is no clear choice of a drug. Hydralazine should no longer be thought of as the primary drug, most studies show a preference for calcium channel blockers...
  95. ncbi Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction
    Ori Nevo
    Department of Obstetrics and Gynecology, Mount Sinai Hospital, 600 University Avenue, Room 871C, Toronto, Ontario, Canada M5G 1X5
    J Clin Endocrinol Metab 93:285-92. 2008
    ....
  96. ncbi Aortic wall thickness in newborns with intrauterine growth restriction
    Michael R Skilton
    Department of Medicine, University of Sydney, Sydney, Australia
    Lancet 365:1484-6. 2005
    ..0001). Newborn babies with growth restriction have significant aortic thickening, suggesting that prenatal events might predispose to later cardiovascular risk...
  97. ncbi Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms
    C L McTernan
    Division of Medical Sciences, Queen Elizabeth Hospital, University of Birmingham, Edgbaston, Birmingham, United Kingdom B15 2TH
    J Clin Endocrinol Metab 86:4979-83. 2001
    ..These data highlight the important role of 11beta-HSD2 in regulating fetal growth, a known factor in determining fetal morbidity but also the subsequent development of cardiovascular disease in adulthood...
  98. ncbi Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Torrance, California 90502, USA
    Reprod Sci 14:329-37. 2007
    ..This reduced anorexigenic function, together with normal or perhaps enhanced orexigenic function, contributes to the development of programmed obesity in IUGR rat offspring...
  99. ncbi Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring
    Yi Xu
    Department of Obstetrics Gynecology, 232 HMRC, Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    FASEB J 20:1251-3. 2006
    ..These findings suggest that hypoxia or undernutrition during development leads to pathological cardiac remodeling, diastolic dysfunction, and increased sensitivity to ischemic injury during adult life...
  100. pmc Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth
    Sara Roos
    Perinatal Center, Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, PO Box 432, SE 405 30 Gothenburg, Sweden
    J Physiol 582:449-59. 2007
    ..We propose that mTOR functions as a placental nutrient sensor, matching fetal growth with maternal nutrient availability by regulating placental nutrient transport...
  101. ncbi Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats
    Mary A Selak
    Department of Pediatrics, Children s Hospital of Philadelphia and University of Pennsylvania, 19104, USA
    Am J Physiol Endocrinol Metab 285:E130-7. 2003
    ..Impaired ATP synthesis in muscle compromises energy-dependent GLUT4 recruitment to the cell surface, glucose transport, and glycogen synthesis, which contribute to insulin resistance and hyperglycemia of type 2 diabetes...

Research Grants74

  1. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ..found in human maternal and fetal circulation, would reduce fetal IGF bioavailability and culminate in fetal growth retardation and low birth weight offspring...
  2. MATERNAL DEHYDRATION--FETAL & AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 1992
    ..maternal dehydration may contribute to the development of oligohydramnios, premature labor, and/or fetal growth retardation. This project will utilize the chronically catheterized ovine model to investigate the ontogeny of fetal ..
  3. THE ROLE OF PLACENTAL LACTOGEN IN FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 1990
    ..on fetal PL receptors may clarify the mechanisms by which maternal fasting and malnutrition give rise to fetal growth retardation. Conversely, studies of the effects of fetal hyperglycemia (and concomitant fetal hyperinsulinemia) on ..
  4. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2003
    Preeclampsia complicates 5-7% of pregnancies, and is a leading cause of fetal growth retardation, premature delivery and maternal death. The cause of preeclampsia is not known...
  5. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2006
    Preeclampsia complicates 5-7% of pregnancies, and is a leading cause of fetal growth retardation, premature delivery and maternal death. The cause of preeclampsia is not known...
  6. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2007
    Preeclampsia complicates 5-7% of pregnancies, and is a leading cause of fetal growth retardation, premature delivery and maternal death. The cause of preeclampsia is not known...
  7. FOLATE-RESPONSIVE DYSGENESIS
    ASOK ANTONY; Fiscal Year: 2004
    ..maternal folate deficiency using antisense FR will adversely affect placental proliferation and result in fetal growth retardation. These studies will use liposomes engineered to deliver antisense FR cDNA incorporated in a placenta ..
  8. The Role of PLAC1 in Placental Growth
    Michael Fant; Fiscal Year: 2003
    ..This suggestion is strengthened by a fetal growth retardation phenotype associated with X chromosome deletions in the region to which PLAC1 maps...
  9. PLAC1 in Placental Development
    Michael Fant; Fiscal Year: 2007
    ..This is strengthened by a fetal growth retardation phenotype and placental growth abnormalities associated with X chromosome deletions in the region to ..
  10. FETAL OXYGENATION AND PLACENTAL GAS EXCHANGE
    LAWRENCE LONGO; Fiscal Year: 1991
    ..We will test the overall hypothesis that such hypoxia throughout gestation results in fetal growth retardation. In addition, we will test hypotheses regarding the roles of several hormones in the cardiovascular ..
  11. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2003
    Preeclampsia is a multisystem disorder unique to human pregnancy. It is a leading cause of fetal growth retardation, infant morbidity and mortality associated with premature delivery, and maternal death...
  12. Preeclampsia and Autoimmunity
    Rodney E Kellems; Fiscal Year: 2010
    ..Do AT1-AAs contribute to fetal growth retardation? D. What pathophysiological consequences of AT1-AAs are independent of pregnancy? AIM II...
  13. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2007
    ..In further studies, we found that fetal growth retardation was not associated with altered hepatic or skeletal muscle proximal insulin signaling during postnatal ..
  14. The Epidemiology of Marine Fatty Acids and Preeclampsia
    Michelle Williams; Fiscal Year: 2006
    ..g., fetal growth retardation and preterm delivery)...
  15. Nicotine and Development of Autonomic Neurons
    Malathi Srivatsan; Fiscal Year: 2006
    Maternal tobacco consumption is well known to cause fetal growth retardation and neurobehavioral disturbances in the offspring. Yet, due to the addictiveness of nicotine in tobacco 20% of U.S...
  16. ENDOTHELIUM DERIVED VASODILATORS IN PREGNANCY
    RONALD MAGNESS; Fiscal Year: 2002
    ..These vasodilatory mechanisms may be reduced in pregnancies complicated by hypertension and/or fetal growth retardation.