chorioamnionitis

Summary

Summary: INFLAMMATION of the placental membranes (CHORION; AMNION) and connected tissues such as fetal BLOOD VESSELS and UMBILICAL CORD. It is often associated with intrauterine ascending infections during PREGNANCY.

Top Publications

  1. pmc The new bronchopulmonary dysplasia
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Curr Opin Pediatr 23:167-72. 2011
  2. ncbi A fetal response to chorioamnionitis is associated with early survival after preterm birth
    Monica M Lahra
    RPA Newborn Care, Royal Prince Alfred Hospital, and the University of Sydney, Sydney, Australia
    Am J Obstet Gynecol 190:147-51. 2004
  3. ncbi The role of inflammation and infection in preterm birth
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Semin Reprod Med 25:21-39. 2007
  4. ncbi Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Hutzel Women s Hospital Detroit, MI 48201, USA
    Nutr Rev 65:S194-202. 2007
  5. pmc The severity of chorioamnionitis in pregnant sheep is associated with in vivo variation of the surface-exposed multiple-banded antigen/gene of Ureaplasma parvum
    Christine L Knox
    Institute of Health and Biomedical Innovation, and School of Life Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    Biol Reprod 83:415-26. 2010
  6. pmc Endotoxin induced chorioamnionitis prevents intestinal development during gestation in fetal sheep
    Tim G A M Wolfs
    Department of Surgery, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 4:e5837. 2009
  7. ncbi Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis
    Y W Wu
    Department of Neurology, University of California, PO Box 0114, San Francisco, CA 94143 0114, USA
    JAMA 284:1417-24. 2000
  8. ncbi Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns
    Raymond W Redline
    Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Pediatr Dev Pathol 6:435-48. 2003
  9. ncbi Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial
    Kristi L Watterberg
    Division of Neonatology, Department of Pediatrics Neonatology, University of New Mexico School of Medicine, MSC10 5590, Albuquerque, NM 87131 0001, USA
    Pediatrics 114:1649-57. 2004
  10. doi Chorioamnionitis: a multiorgan disease of the fetus?
    M Gantert
    Department of Obstetrics and Gynecology, Klinikum Osnabruck, Osnabruck, Germany
    J Perinatol 30:S21-30. 2010

Detail Information

Publications249 found, 100 shown here

  1. pmc The new bronchopulmonary dysplasia
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Curr Opin Pediatr 23:167-72. 2011
    ..Bronchopulmonary dysplasia (BPD) remains the most common severe complication of preterm birth. A number of recent animal models and clinical studies provide new information about pathophysiology and treatment...
  2. ncbi A fetal response to chorioamnionitis is associated with early survival after preterm birth
    Monica M Lahra
    RPA Newborn Care, Royal Prince Alfred Hospital, and the University of Sydney, Sydney, Australia
    Am J Obstet Gynecol 190:147-51. 2004
    ..was to determine, in a large preterm cohort (20-34 completed weeks of gestation), the incidence of histologic chorioamnionitis and the incidence of a histologic fetal response to chorioamnionitis (umbilical vasculitis with or without ..
  3. ncbi The role of inflammation and infection in preterm birth
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Semin Reprod Med 25:21-39. 2007
    ..Most cases of histopathological inflammation and histological chorioamnionitis, both in preterm and term labor, are sub-clinical in nature...
  4. ncbi Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Hutzel Women s Hospital Detroit, MI 48201, USA
    Nutr Rev 65:S194-202. 2007
    ..Moreover, reprogramming of the fetal immune response may predispose to diseases in adulthood...
  5. pmc The severity of chorioamnionitis in pregnant sheep is associated with in vivo variation of the surface-exposed multiple-banded antigen/gene of Ureaplasma parvum
    Christine L Knox
    Institute of Health and Biomedical Innovation, and School of Life Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    Biol Reprod 83:415-26. 2010
    ..005), and ureaplasma titers were inversely related to the number of variants (P = 0.025). The severity of chorioamnionitis varied between animals...
  6. pmc Endotoxin induced chorioamnionitis prevents intestinal development during gestation in fetal sheep
    Tim G A M Wolfs
    Department of Surgery, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 4:e5837. 2009
    b>Chorioamnionitis is the most significant source of prenatal inflammation and preterm delivery...
  7. ncbi Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis
    Y W Wu
    Department of Neurology, University of California, PO Box 0114, San Francisco, CA 94143 0114, USA
    JAMA 284:1417-24. 2000
    b>Chorioamnionitis has been implicated in the pathogenesis of cerebral palsy, but most studies have not reported a significant association...
  8. ncbi Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns
    Raymond W Redline
    Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Pediatr Dev Pathol 6:435-48. 2003
    ..6, substantial. Kappa values for the 12 lesions evaluated in 20 cases by the six pathologists were: acute chorioamnionitis/maternal inflammatory response (any, 0.93; severe 0.76; advanced stage, 0...
  9. ncbi Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial
    Kristi L Watterberg
    Division of Neonatology, Department of Pediatrics Neonatology, University of New Mexico School of Medicine, MSC10 5590, Albuquerque, NM 87131 0001, USA
    Pediatrics 114:1649-57. 2004
    ..A pilot study of low-dose hydrocortisone therapy for prophylaxis of early adrenal insufficiency showed improved survival without BPD at 36 weeks' postmenstrual age, particularly in infants exposed to histologic chorioamnionitis.
  10. doi Chorioamnionitis: a multiorgan disease of the fetus?
    M Gantert
    Department of Obstetrics and Gynecology, Klinikum Osnabruck, Osnabruck, Germany
    J Perinatol 30:S21-30. 2010
    The bacterial infection of chorion and amnion is a common finding in premature delivery and is referred to as chorioamnionitis. As the mother rarely shows symptoms of a systemic inflammation, the course of chorioamnionitis is frequently ..
  11. doi The bacterial load of Ureaplasma parvum in amniotic fluid is correlated with an increased intrauterine inflammatory response
    David C Kasper
    Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, A 1090 Vienna, Austria
    Diagn Microbiol Infect Dis 67:117-21. 2010
    ..isolated microorganisms inside the amniotic cavity and have been associated with spontaneous abortion, chorioamnionitis, premature rupture of the membranes (PROM), and preterm labor (PL)...
  12. pmc Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes
    Daniel B Digiulio
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Am J Reprod Immunol 64:38-57. 2010
    ..The role played by microbial invasion of the amniotic cavity (MIAC) in preterm pre-labor rupture of membranes (pPROM) is inadequately characterized, in part because of reliance on cultivation-based methods...
  13. doi Chorioamnionitis--a complex pathophysiologic syndrome
    R Menon
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Placenta 31:113-20. 2010
    b>Chorioamnionitis, inflammation of the amniochorionic membrane (fetal membranes) is a very common disease but a complex syndrome associated with pregnancy...
  14. ncbi Inflammatory responses in the placenta and umbilical cord
    Raymond W Redline
    Case School of Medicine, Department of Pathology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Semin Fetal Neonatal Med 11:296-301. 2006
    ..Histological chorioamnionitis develops through a well-characterised stereotyped progression of maternal and fetal cellular stages that vary ..
  15. ncbi Hemodynamic disturbances in premature infants born after chorioamnionitis: association with cord blood cytokine concentrations
    Toby Debra Yanowitz
    Department of Pediatrics, Division of Neonatology, University of Pittsburgh School of Medicine and the Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Pediatr Res 51:310-6. 2002
    b>Chorioamnionitis and elevated cord blood inflammatory cytokine concentrations are associated with detectable disturbances of systemic and cerebral hemodynamics in premature newborns. Fifty-five infants (25-31 wk gestation) were enrolled...
  16. ncbi Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants
    Linda J Van Marter
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Pediatr 140:171-6. 2002
    This case-control study of chronic lung disease (CLD) evaluated the hypothesis that chorioamnionitis promotes CLD and interacts with other risk factors for CLD, including mechanical ventilation and postnatal infection.
  17. doi Chorioamnionitis and cerebral palsy: a meta-analysis
    Jobe G Shatrov
    School of Medicine, Sydney, The University of Notre Dame Australia and Cerebral Palsy Institute, Darlinghurst, New South Wales, Australia
    Obstet Gynecol 116:387-92. 2010
    To examine the relationships between clinical or histological chorioamnionitis and cerebral palsy using a meta-analysis approach.
  18. ncbi Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers
    Michael G Gravett
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Ore, USA
    JAMA 292:462-9. 2004
    ..Intra-amniotic infection (IAI) is commonly associated with preterm birth and adverse neonatal sequelae. Early diagnosis of IAI, however, has been hindered by insensitive or nonspecific tests...
  19. ncbi Dose and time response after intraamniotic endotoxin in preterm lambs
    B W Kramer
    Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    Am J Respir Crit Care Med 164:982-8. 2001
    Intraamniotic endotoxin causes chorioamnionitis, which is followed by improved fetal lung function after 4 d in fetal sheep. We evaluated 0.1 mg, 1 mg, 4 mg, and 10 mg endotoxin for inflammation and lung maturation effects after 7 d...
  20. pmc Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study
    Rajesh Kumar
    Division of Allergy, Children s Memorial Hospital, Chicago, IL 60614, USA
    J Allergy Clin Immunol 121:878-84.e6. 2008
    Prematurity (< 37 weeks) has been inconsistently associated with asthma and wheezing. Chorioamnionitis may promote both prematurity and inflammatory pathways in infants' airways.
  21. pmc Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs
    Elke Kuypers
    Department of Pediatrics, School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 302:L380-9. 2012
    The proinflammatory stimulus of chorioamnionitis is commonly associated with preterm delivery. Women at risk of preterm delivery receive antenatal glucocorticoids to functionally mature the fetal lung...
  22. doi Maternal versus fetal inflammation and respiratory distress syndrome: a 10-year hospital cohort study
    M M Lahra
    Department of Neonatal Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Arch Dis Child Fetal Neonatal Ed 94:F13-6. 2009
    To determine the impact of maternal and fetal intrauterine inflammatory responses (chorioamnionitis and umbilical vasculitis) on the development of neonatal respiratory distress syndrome (RDS) in preterm infants.
  23. ncbi Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital, Bagot Road, Subiaco, Perth, WA 6008, Australia
    Am J Obstet Gynecol 189:1458-66. 2003
    Intra-amniotic administration of endotoxin in sheep is a model of subclinical chorioamnionitis. Intrauterine inflammation alters lung development to improve postnatal lung function and may predispose the infant to lung and brain injury...
  24. doi Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis
    Michela Torricelli
    Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, 53100, Siena, Italy
    J Clin Endocrinol Metab 96:534-40. 2011
    ..The pathogenesis of preterm delivery (PTD) is not clear, although inflammation/infection play a major role. Corticotropin releasing-hormone (CRH) and Urocortins (Ucns) are involved in the pathophysiology of PTD...
  25. pmc Modulation of fetal inflammatory response on exposure to lipopolysaccharide by chorioamnion, lung, or gut in sheep
    Boris W Kramer
    University Medical Center Maastricht, The Netherlands
    Am J Obstet Gynecol 202:77.e1-9. 2010
    ..We hypothesized that fetal lipopolysaccharide exposures to the chorioamnion, lung, or gut would induce distinct systemic inflammatory responses...
  26. ncbi Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB
    Lawrence S Prince
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Am J Physiol Lung Cell Mol Physiol 287:L999-1006. 2004
    b>Chorioamnionitis is a major cause of preterm delivery. Infants exposed to inflammation in utero and then born preterm may have improved lung function in the immediate postnatal period...
  27. doi Chorioamnionitis--the good or the evil for neonatal outcome?
    Iliana Bersani
    University Children s Hospital, University of Wurzburg, Germany
    J Matern Fetal Neonatal Med 25:12-6. 2012
    b>Chorioamnionitis represents a major risk factor for preterm birth and contributes to prematurity-associated morbidity and mortality...
  28. doi Prostaglandins mediate the fetal pulmonary response to intrauterine inflammation
    Alana J Westover
    The Ritchie Centre, Monash Institute of Medical Research, Clayton, Vic, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L664-78. 2012
    ..Nimesulide decreased surfactant protein (SP)-A (P = 0.05), -B (P = 0.05), and -D (P = 0.0015) but increased SP-C mRNA (P = 0.023). Thus PGHS-2 mediates, at least in part, fetal pulmonary responses to inflammation...
  29. ncbi Histologic chorioamnionitis and severity of illness in very low birth weight newborns
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci 16, I 53100 Siena, Italy
    Pediatr Crit Care Med 6:298-302. 2005
    ..Histologic chorioamnionitis (HCA) is a known cause of neonatal morbidity and mortality...
  30. doi The risk of intra-amniotic infection, inflammation and histologic chorioamnionitis in term pregnant women with intact membranes and labor
    Seung Mi Lee
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Republic of Korea
    Placenta 32:516-21. 2011
    ..an increased risk of microbial invasion of the amniotic cavity, intra-amniotic inflammation and histologic chorioamnionitis. This study was performed to determine when the risk of intra-amniotic infection, inflammation and histologic ..
  31. doi Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis
    Lisa Hartling
    Department of Pediatrics, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada
    Arch Dis Child Fetal Neonatal Ed 97:F8-F17. 2012
    To conduct a systematic review of the association between chorioamnionitis (CA) and bronchopulmonary dysplasia (BPD) in preterm infants.
  32. doi Histological inflammatory responses in the placenta and early neonatal brain injury
    Vincenzo Zanardo
    Department of Pediatrics, Padua University School of Medicine, Padua, Italy
    Pediatr Dev Pathol 11:350-4. 2008
    ..Placental histology for histological chorioamnionitis (HCA) was graded and scored according to Redline and others...
  33. doi Non-invasive prediction of intra-amniotic inflammation in women with preterm labor
    H J Jung
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnamsi, Korea
    Ultrasound Obstet Gynecol 37:82-7. 2011
    ..To develop a model based on non-invasive variables to predict the probability of intra-amniotic inflammation in women with preterm labor and intact membranes...
  34. ncbi Postnatal increase of procalcitonin in premature newborns is enhanced by chorioamnionitis and neonatal sepsis
    J Janota
    Institute for the Care of Mother and Child, Podolske nabrezi 157, 147 00 Prague 4, Czech Republic
    Eur J Clin Invest 31:978-83. 2001
    To determine the influence of chorioamnionitis and neonatal sepsis on procalcitonin (PCT) levels in very-low-birth-weight (VLBW) infants within the first week of life.
  35. ncbi The role of inflammation in the development of chronic lung disease in neonates
    J J De Dooy
    Department of Paediatrics, University Hospital of Antwerp, Belgium
    Eur J Pediatr 160:457-63. 2001
    Chronic lung disease (CLD) has been associated with chorioamnionitis and upper respiratory tract colonisation with Ureaplasma urealyticum...
  36. pmc Regulation of interleukin-6 expression in human decidual cells and its potential role in chorioamnionitis
    Charles J Lockwood
    Department of Obstetrics, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Am J Pathol 177:1755-64. 2010
    b>Chorioamnionitis frequently precedes both genital tract and placental inflammation and is both a primary cause of maternal morbidity and a major antecedent of preterm premature rupture of the membranes (PPROM) as well as preterm delivery (..
  37. pmc Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 24:1444-55. 2011
    ..intra-amniotic infection/inflammation (IAI) is associated with changes in amniotic fluid concentrations of HMGB1; and (2) localize immunoreactivity of HMGB1 in the fetal membranes and umbilical cord of patients with chorioamnionitis.
  38. ncbi Chorioamnionitis and the prognosis for term infants
    J M Alexander
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Obstet Gynecol 94:274-8. 1999
    To assess the effects of clinical chorioamnionitis and labor complications on short-term neonatal morbidity, including seizures.
  39. doi Effects of intrauterine infection or inflammation on fetal lung development
    Alana J Westover
    The Ritchie Centre, Monash Institute of Medical Research, Clayton, Victoria, Australia
    Clin Exp Pharmacol Physiol 39:824-30. 2012
    ..Elucidation of the effects of inflammation on the fetal lungs and other organs will allow more refined approaches to the care of preterm infants exposed to inflammation in utero...
  40. ncbi C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis
    B H Yoon
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Laboratory of Fetal Medicine Research, Clinical Research Institute, Seoul, Korea
    J Matern Fetal Neonatal Med 14:85-90. 2003
    ....
  41. doi Chorioamnionitis induced by intraamniotic lipopolysaccharide resulted in an interval-dependent increase in central nervous system injury in the fetal sheep
    A W Danilo Gavilanes
    Department of Pediatrics Neonatology, University Hospital Maastricht, in collaboration with the Research Institute of Growth and Development GROW, Maastricht, The Netherlands
    Am J Obstet Gynecol 200:437.e1-8. 2009
    We quantified the impact of chorioamnionitis on both the white and gray matter structures of the preterm ovine central nervous system (CNS).
  42. doi Chorioamnionitis, respiratory distress syndrome and bronchopulmonary dysplasia in extremely low birth weight infants
    Hyun Ju Lee
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    J Perinatol 31:166-70. 2011
    To determine if histologic chorioamnionitis (HC) in the presence of respiratory distress syndrome (RDS) augments adverse pulmonary outcomes in extremely low birth weight (ELBW) infants.
  43. doi The involvement of human amnion in histologic chorioamnionitis is an indicator that a fetal and an intra-amniotic inflammatory response is more likely and severe: clinical implications
    Chan Wook Park
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Placenta 30:56-61. 2009
    ....
  44. ncbi Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes
    Soon Sup Shim
    Department of Obstetrics and Gynecology, Laboratory of Fetal Medicine Research, College of Medicine, Seoul National University Seoul 110 744, Korea
    Am J Obstet Gynecol 191:1339-45. 2004
    ..This study was conducted to determine the frequency and clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of the membranes...
  45. pmc Diagnosis and management of clinical chorioamnionitis
    Alan T N Tita
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Alabama at Birmingham, 619 19th South, Birmingham, AL 3524, USA
    Clin Perinatol 37:339-54. 2010
    b>Chorioamnionitis is a common complication of pregnancy associated with significant maternal, perinatal, and long-term adverse outcomes...
  46. pmc Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum
    Graeme R Polglase
    The University of Western Australia, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 299:L232-41. 2010
    Ureaplasma species, the most commonly isolated microorganisms in women with chorioamnionitis, are associated with preterm delivery...
  47. doi Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants
    Tobias Strunk
    Department of Neonatal Paediatrics, King Edward Memorial Hospital for Women and Princess Margaret Hospital for Children, Subiaco, Australia
    Pediatrics 129:e134-41. 2012
    Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis and may modulate postnatal immunity...
  48. ncbi Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function at school age in extremely low birth weight infants (<1 kg)
    Raymond W Redline
    Department of Pathology, Case School of Medicine and Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Pediatr Dev Pathol 10:282-92. 2007
    ..Histologic chorioamnionitis (HCA) was not predictive of outcome in the population as a whole, but a severe fetal vascular response was ..
  49. ncbi Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra-amniotic infection
    M Sean Esplin
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    J Matern Fetal Neonatal Med 17:365-73. 2005
    ..This study was conducted to determine if preterm labor leading to preterm delivery and intra-amniotic infection (IAI) are associated with changes in the amniotic fluid concentrations of MCP-1...
  50. pmc Prenatal inflammation and lung development
    Boris W Kramer
    Department of kindergeneeskunde, Academisch Ziekenhuis Maastricht, Postbus 5800, 6202 AZ Maastricht, The Netherlands
    Semin Fetal Neonatal Med 14:2-7. 2009
    Prenatal exposure of very low birth weight infants to chronic indolent chorioamnionitis with organisms such as mycoplasma and ureaplasma is frequent...
  51. ncbi Chorioamnionitis and cerebral palsy in term and near-term infants
    Yvonne W Wu
    Department of Neurology, University of California, San Francisco 94143, USA
    JAMA 290:2677-84. 2003
    Half of all cases of cerebral palsy (CP) occur in term infants, for whom risk factors have not been clearly defined. Recent studies suggest a possible role of chorioamnionitis.
  52. doi Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Pediatr Dev Pathol 11:15-22. 2008
    ..Recovery of microorganisms from placental parenchyma is associated with histologic inflammation. The same microorganisms responsible for inciting high-grade chorionic plate inflammation are also most likely to promote fetal inflammation...
  53. pmc Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection
    Mi Jeong Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Lab Invest 89:924-36. 2009
    Acute chorioamnionitis is a response to amniotic fluid (AF) infection...
  54. ncbi Clinical chorioamnionitis, elevated cytokines, and brain injury in term infants
    Lina F Shalak
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatrics 110:673-80. 2002
    To determine the initial inflammatory cytokine response in term infants born to mothers with clinical chorioamnionitis and to assess whether the cytokine response is associated with birth depression, abnormal neurologic examination, and ..
  55. ncbi Planned early birth versus expectant management for women with preterm prelabour rupture of membranes prior to 37 weeks' gestation for improving pregnancy outcome
    Sarah L Buchanan
    Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, New South Wales, Australia, 2065
    Cochrane Database Syst Rev 3:CD004735. 2010
    ..32, 95% CI 1.33 to 4.07), but that early delivery had no effect on chorioamnionitis (RR 0.44, 95% CI 0.17 to 1.14)...
  56. ncbi Inflammation and bronchopulmonary dysplasia
    Christian P Speer
    University Children s Hospital, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Semin Neonatol 8:29-38. 2003
    ....
  57. doi Effect of chorioamnionitis on early childhood asthma
    Darios Getahun
    Department of Research and Evaluation, Kaiser Permanente Southern California Medical Group, 100 Los Robles Ave, 2nd Floor, Pasadena, CA 91101, USA
    Arch Pediatr Adolesc Med 164:187-92. 2010
    To examine the association between chorioamnionitis and childhood asthma based on gestational age at birth and race/ethnicity.
  58. ncbi Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants
    Tuula Kaukola
    Department of Pediatrics, University of Oulu, FIN 90014 Oulu, Finland
    Pediatr Res 59:478-83. 2006
    ..We investigated the relationship between chorioamnionitis, cord serum cytokines, and neurologic outcome...
  59. doi Chorioamnionitis, postnatal factors and proinflammatory response in the pathogenetic sequence of bronchopulmonary dysplasia
    Christian P Speer
    University Children s Hospital, Wurzburg, Germany
    Neonatology 95:353-61. 2009
    ..Pre- and postnatal factors such as chorioamnionitis, oxygen toxicity, mechanical ventilation and postnatal infections can induce and perpetuate an injurious and ..
  60. pmc The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    Clin Perinatol 37:355-74. 2010
    ..Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap...
  61. ncbi Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis
    Yeon Mee Kim
    Perinatology Research Branch, National Institute of Child Health and Human Development NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 191:1346-55. 2004
    ..This study examined Toll-like receptor-2 and -4 expression in fetal membranes in response to labor at term and histologic chorioamnionitis.
  62. ncbi Intra-amniotic endotoxin: chorioamnionitis precedes lung maturation in preterm lambs
    S G Kallapur
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 280:L527-36. 2001
    ....
  63. ncbi Endotoxin-induced maturation of monocytes in preterm fetal sheep lung
    Boris W Kramer
    University Hospital Maastricht, Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 293:L345-53. 2007
    The fetal lung normally contains immature monocytes and very few mature macrophages. The chorioamnionitis frequently associated with preterm birth induces monocyte influx into the fetal lung...
  64. ncbi Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes
    B H Yoon
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea
    Am J Obstet Gynecol 185:1130-6. 2001
    ..Adverse outcomes included clinical and histologic chorioamnionitis, funisitis, early preterm birth, and significant neonatal morbidity...
  65. doi Chorioamnionitis alters the response to surfactant in preterm infants
    Jasper V Been
    Department of Paediatrics, School for Oncology and Developmental Biology GROW, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Pediatr 156:10-15.e1. 2010
    To study the association between antenatal exposure to chorioamnionitis and the neonatal response to surfactant.
  66. pmc IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 179:955-61. 2009
    b>Chorioamnionitis frequently associates with preterm delivery and increased amniotic fluid IL-1, and causes fetal lung and systemic inflammation...
  67. doi Histological chorioamnionitis and respiratory outcome in preterm infants
    J V Been
    Department of Paediatrics, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Arch Dis Child Fetal Neonatal Ed 94:F218-25. 2009
    ..Initial reports suggest that in preterm infants histological chorioamnionitis is associated with a decreased incidence of respiratory distress syndrome (RDS), while the incidence of ..
  68. ncbi Local inflammatory response in choriodecidua induced by Ureaplasma urealyticum
    R Aaltonen
    Department of Obstetrics and Gynecology, Turku University Hospital, Turku, Finland
    BJOG 114:1432-5. 2007
    ..Lower quantities of bacteria failed to induce any response...
  69. ncbi Cytokine production in chorioamnionitis
    F Saji
    Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    J Reprod Immunol 47:185-96. 2000
    ..b>Chorioamnionitis, a subset of intrauterine infection, has been identified in 20-33% of women with preterm delivery, and the ..
  70. ncbi The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes
    Yasemin Tasci
    Department of Obstetrics, Ministry of Health Ankara, Etlik Maternity and Women s Health Research Training Hospital, Guvenlik Cad, 21 5, 06190 Kavaklidere, Ankara, Turkey
    Eur J Obstet Gynecol Reprod Biol 128:34-9. 2006
    The objective was to determine whether the interleukin-6 (IL-6) level in umbilical cord blood can be used for the prediction of histologic chorioamnionitis, funisitis, fetal membrane cultures and neonatal infection.
  71. pmc Performance characteristics of putative tests for subclinical chorioamnionitis
    R K Edwards
    Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610-0294, USA
    Infect Dis Obstet Gynecol 9:209-14. 2001
    ..fluid glucose, matrix metalloproteinase (MMP)-9, interleukin (IL)-6, and IL-12 for diagnosing subclinical chorioamnionitis in women with preterm labor...
  72. ncbi Indomethacin responsiveness of patent ductus arteriosus and renal abnormalities in preterm infants treated with indomethacin
    Kazuo Itabashi
    Children s Medical Center, Northern Yokohama Hospital, 35 1 Chigasakityuo, Tsuzukiku, Yokohama 224 8503, Japan
    J Pediatr 143:203-7. 2003
    ..We evaluated the factors related to indomethacin responsiveness of the patent ductus arteriosus (PDA) and subsequent renal and electrolyte abnormalities in a large number of low birth weight infants...
  73. ncbi Prevalence, management, and outcomes of preterm prelabour rupture of the membranes of women in Canada
    Graeme Smith
    Department of Obstetrics and Gynaecology, Queen s University, Kingston, Ontario, Canada
    J Obstet Gynaecol Can 27:547-53. 2005
    ..To determine the prevalence of preterm prelabour rupture of the membranes (PPROM) at Canadian university-affiliated perinatal referral centres, to assess the different management strategies, and to review neonatal outcomes...
  74. doi Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis
    J V Been
    Department of Paediatrics, Maastricht University Medical Centre, The Netherlands
    BJOG 118:113-22. 2011
    There is debate concerning the safety and efficacy of antenatal steroids in preterm labour with suspected intrauterine infection (chorioamnionitis).
  75. ncbi Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating fetal interleukin-6 serum concentration
    K Shimoya
    Department of Obstetrics and Gynecology, Faculty of Medicine Osaka University, Suita City, Japan
    Hum Reprod 15:2234-40. 2000
    ..The interleukin-6 (IL-6) titre in cord sera of RDS-free neonates born to mothers with histological chorioamnionitis was significantly higher than that in RDS-complicated neonates without chorioamnionitis...
  76. pmc Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep
    Steffen Kunzmann
    University Children s Hospital, Wurzburg, Germany
    Am J Obstet Gynecol 202:476.e1-9. 2010
    ..We asked whether fetal inflammation caused by chorioamnionitis would modulate thymus development.
  77. pmc The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor
    Seung Mi Lee
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    J Matern Fetal Neonatal Med 24:37-42. 2011
    To examine the frequency and risk factors of funisitis and histologic chorioamnionitis in the placentas of term pregnant women who delivered after the spontaneous onset of labor.
  78. ncbi Preterm histologic chorioamnionitis: impact on cord gas and pH values and neonatal outcome
    Bryan S Richardson
    Department of Obstetrics and Gynaecology, St Joseph s Health Care, University of Western Ontario, London, Ontario, Canada
    Am J Obstet Gynecol 195:1357-65. 2006
    The purpose of this study was to further delineate the impact of preterm chorioamnionitis on a spectrum of neonatal outcomes using a large tertiary hospital population.
  79. pmc Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndrome
    Sun Kwon Kim
    Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:543-52. 2009
    ..The aim of this study was to determine whether fetal and maternal granulocytes and monocytes have the phenotypic and metabolic characteristics of activation in cases with FIRS...
  80. ncbi Chorioamnionitis and pregnancy outcome in HIV-infected African women. Pregnancy and HIV Study Group
    J Ladner
    Medical Information Unit, Centre Hospitalier de Kigali, Rwanda
    J Acquir Immune Defic Syndr Hum Retrovirol 18:293-8. 1998
    To assess the role of chorioamnionitis (CAM) on pregnancy outcome in HIV-1-infected (HIV-positive) pregnant women, treated for sexually transmitted diseases (STDs), during the last trimester of pregnancy in Kigali, Rwanda.
  81. doi The importance of intra-amniotic inflammation in the subsequent development of atypical chronic lung disease
    Joonho Lee
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Matern Fetal Neonatal Med 22:917-23. 2009
    ..To examine whether the intra-amniotic inflammation is a risk factor for the development of atypical chronic lung disease (CLD)...
  82. pmc Chronic chorioamnionitis displays distinct alterations of the amniotic fluid proteome
    Giovanna Ogge
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    J Pathol 223:553-65. 2011
    Acute chorioamnionitis of infectious origin and chronic chorioamnionitis of immunological origin are two major placental lesions of spontaneous preterm birth with elevated amniotic fluid interleukin-6 and CXCL10 concentrations, ..
  83. ncbi Fetal thymus size as a predictor of chorioamnionitis in women with preterm premature rupture of membranes
    Y Yinon
    Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ultrasound Obstet Gynecol 29:639-43. 2007
    Emerging evidence indicates that chorioamnionitis is associated with a significant decrease in thymic size at birth in very low birth weight (VLBW) preterm infants...
  84. doi MMP-9 and TIMP-1 in the cord blood of premature infants developing BPD
    Shinnosuke Fukunaga
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Pediatr Pulmonol 44:267-72. 2009
    ..030, respectively). The MMP-9 levels and MMP-9/TIMP-1 ratios correlated with the severity of maternal chorioamnionitis (both trend P = 0.006)...
  85. doi Histologic chorioamnionitis is more common after spontaneous labor than after induced labor at term
    H S Park
    Department of Obstetrics and Gynecology, Graduate School of Medicine, Dongguk University, Seoul, South Korea
    Placenta 31:792-5. 2010
    Inflammation of the chorioamniotic membranes (histologic chorioamnionitis) is a risk factor for adverse neonatal outcome...
  86. ncbi Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes
    Patrick S Ramsey
    Division of Maternal Fetal Medicine, Department of Obstetrics Gynecology, 458 Old Hillman Building, 619 19th St South, Birmingham, AL, USA
    Am J Obstet Gynecol 192:1162-6. 2005
    To compare morbidities of neonates born to women who developed chorioamnionitis after premature preterm rupture of membranes versus those who did not.
  87. ncbi Umbilical cord blood concentrations of IL-6, IL-8, and MMP-8 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis
    Ctirad Andrys
    Department of Clinical Immunology and Allergy, Charles UniversityPrague, Czech Republic
    Neuro Endocrinol Lett 31:857-63. 2010
    ..interleukin-8 (IL-8), and matrix metalloproteinase-8 (MMP-8) are of value in the diagnosis of histological chorioamnionitis (HCA) and funisitis in patients with preterm premature rupture of membranes (PPROM)...
  88. ncbi Facklamia hominis causing chorioamnionitis and puerperal bacteraemia
    B Healy
    Microbiology Cardiff, NPHS Wales, UHW, Heath Park, Cardiff CF14 4XW, UK
    J Infect 50:353-5. 2005
  89. ncbi Neonatal morbidity and placental pathology
    Rajeev Mehta
    Department of Pediatrics, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    Indian J Pediatr 73:25-8. 2006
    ..To investigate the association between gestational age, placental pathology and outcome among preterm births...
  90. doi Accuracy of C-reactive protein determination in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes: a systematic review
    Rafli van de Laar
    Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 147:124-9. 2009
    ..The aim of this review was to assess whether CRP accurately predicts chorioamnionitis and/or neonatal sepsis in women with PPROM...
  91. pmc The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth
    Chong Jai Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Mod Pathol 23:1000-11. 2010
    Acute chorioamnionitis is a well-established lesion of the placenta in cases with intra-amniotic infection. In contrast, the clinicopathological significance of chronic chorioamnionitis is unclear...
  92. doi Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns
    Francesca Moscuzza
    Neonatology and Neonatal Intensive Care Unit, Department of Pediatrics, S Chiara Hospital University of Pisa, Italy
    Gynecol Endocrinol 27:319-23. 2011
    ..Placental anatomopathologic lesions are usually associated with pregnancy complications and neonatal impaired outcome...
  93. ncbi Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery
    Brenna L Anderson
    Division of Reproductive Infectious Diseases and Immunology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Obstet Gynecol 196:524.e1-5. 2007
    ..The objective of the study was to determine the frequency of adverse pregnancy outcomes in women with untreated asymptomatic group B beta-hemolytic streptococcal (GBS) bacteriuria during pregnancy...
  94. ncbi Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation
    Si Eun Lee
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    J Matern Fetal Neonatal Med 19:693-7. 2006
    ..The purpose of this study was to examine the relationship between funisitis and the microbiologic status of amniotic fluid (AF) and AF white blood cell (WBC) count in patients at term...
  95. ncbi The Alabama Preterm Birth study: polymorphonuclear and mononuclear cell placental infiltrations, other markers of inflammation, and outcomes in 23- to 32-week preterm newborn infants
    William W Andrews
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233 1602, USA
    Am J Obstet Gynecol 195:803-8. 2006
    ..The purpose of this study was to better understand the relationship between placental polymorphonuclear and mononuclear cell infiltrations with bacterial cultures, markers of inflammation, and preterm outcomes...
  96. ncbi Value of amniotic fluid interleukin-8 for the prediction of histological chorioamnionitis in preterm premature rupture of membranes
    Marian Kacerovsky
    Department of Obstetrics and Gynaecology, Charles University in Prague, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
    Neuro Endocrinol Lett 30:733-8. 2009
    To determine whether amniotic fluid levels of interleukin-8 (IL-8) are of value in the antenatal diagnosis of acute histological chorioamnionitis (HCA) in preterm premature rupture of membranes (PPROM).
  97. doi Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome?
    Wolfgang Thomas
    University Children s Hospital Wurzburg, Wurzburg, Germany
    Neonatology 99:177-87. 2011
    b>Chorioamnionitis as a major risk factor for spontaneous preterm birth, especially at earlier gestational ages, contributes to prematurity-associated mortality and morbidity...
  98. pmc Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease
    Mi Jeong Kim
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 and Detroit, MI 48201, USA
    J Immunol 182:3919-27. 2009
    ..In contrast to acute chorioamnionitis of infection-related origin, the fundamental immunopathology of VUE is unknown...
  99. ncbi Special relationships between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates
    Robert Mittendorf
    Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL 60153, USA
    J Perinat Med 33:428-34. 2005
    ....
  100. ncbi Chorioamnionitis and increased neonatal lung lavage fluid matrix metalloproteinase-9 levels: implications for antenatal origins of chronic lung disease
    Anna E Curley
    Department of Child Health, Queen s University of Belfast, Institute of Clinical Science, Belfast, Northern Ireland
    Am J Obstet Gynecol 188:871-5. 2003
    ..We studied the effects of chorioamnionitis and antenatal corticosteroids on bronchoalveolar lavage (BAL) fluid levels of MMP-9, and its inhibitor, TIMP-..
  101. ncbi Meconium-stained amniotic fluid and neonatal morbidity in near-term and term deliveries with acute histologic chorioamnionitis and/or funisitis
    S Rao
    University of Southern California Keck School of Medicine, Department of Pediatrics, Division of Neonatology, Women's and Children's Hospital, 1240 North Mission Road, Los Angeles, CA 90033, USA
    J Perinatol 21:537-40. 2001
    ..amniotic fluid (MSAF) and neonatal morbidity in near-term and term deliveries with histologic acute chorioamnionitis and/or funisitis compared to those with normal placental histology...

Research Grants80

  1. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
    Clinically overt infection of the placenta, fetal membranes, or uterus during labor (chorioamnionitis) complicates from 1% to 11% of pregnancies...
  2. Bacterial Vaginosis and Spontaneous Abortion
    Deborah Nelson; Fiscal Year: 2004
    ..associations between BV and late pregnancy outcomes; such as, preterm labor, premature rupture of membrane, chorioamnionitis, and low birth weight. The impact of BV on the risk for spontaneous abortion (SAB) is unclear...
  3. Postnatal Consequences of Fetal Inflammation
    Alan Jobe; Fiscal Year: 2007
    ..The majority of very low birth weight preterm infants are exposed to chronic indolent chorioamnionitis (inflammation) that can alter lung development and result in bronchopulmonary dysplasia...
  4. Safety of N-acetylcysteine in Maternal Chorioamnionitis
    Dorothea Jenkins; Fiscal Year: 2009
    ..N-acetylcysteine (NAC) is a promising therapy that has shown effective neuroprotection in the animal model of chorioamnionitis, and has a favorable safety profile with known side effects, which appear to be limited and manageable...
  5. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2006
    ..role of increased antigenic stimulation from lower genital tract infection as a determinant of endometritis, chorioamnionitis and preterm birth among African American and white women. 2...
  6. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2007
    ..g., chorioamnionitis) with no symptoms or who have presentations that are considered equivocal, and 2) infants with respiratory ..
  7. Neonatal Resuscitation and Preterm Lung Injury
    Alan Jobe; Fiscal Year: 2007
    ..The majority of infants with birth weights <1 kg have been exposed to chorioamnionitis, which causes lung inflammation and alters innate inflammatory responses...
  8. Type 1 fimbrial variation in E coil 018 k1 h7 virulence
    Scott Weissman; Fiscal Year: 2007
    ..Such a test might ultimately be used to identify women at increased risk of chorioamnionitis and pre-term labor, or of delivering infected newborns...
  9. Safety of N-acetylcysteine in Maternal Chorioamnionitis
    Dorothea Jenkins; Fiscal Year: 2007
    ..N-acetylcysteine (NAC) is a promising therapy that has shown effective neuroprotection in the animal model of chorioamnionitis, and has a favorable safety profile with known side effects, which appear to be limited and manageable...
  10. FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
    Lawrence S Prince; Fiscal Year: 2010
    ..Prenatal exposure to chorioamnionitis (inflammation of the maternal membranes, placenta, and uterus) increases the risk of bronchopulmonary ..
  11. FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
    LAWRENCE PRINCE; Fiscal Year: 2009
    ..Prenatal exposure to chorioamnionitis (inflammation of the maternal membranes, placenta, and uterus) increases the risk of bronchopulmonary ..
  12. Consequences of redox imbalance in preterm parturition
    Irina Buhimschi; Fiscal Year: 2003
    Both intrauterine (e.g. chorioamnionitis) and various matemal systemic infections are proposed causes of preterm labor triggered by a protective inflammatory response (based on the finding of elevated cytokines) that becomes maladaptive ..
  13. HIV, Malaria and Neurobehavioral Development in Early Childhood
    Penny A Holding; Fiscal Year: 2010
    ..are mediated by pre-term birth, intrauterine growth retardation (IUGR) and placenta! abnormalities, including chorioamnionitis. LBW and placenta! abnormalities, in turn, lead to developmental delays and to a slowed rate of development ..
  14. HIV, Malaria and Neurobehavioral Development in Early Childhood
    Penny Holding; Fiscal Year: 2007
    ..are mediated by pre-term birth, intrauterine growth retardation (IUGR) and placenta! abnormalities, including chorioamnionitis. LBW and placenta! abnormalities, in turn, lead to developmental delays and to a slowed rate of development ..