chorioamnionitis

Summary

Summary: INFLAMMATION of the placental membranes (CHORION; AMNION) and connected tissues such as fetal BLOOD VESSELS and UMBILICAL CORD. It is often associated with intrauterine ascending infections during PREGNANCY.

Top Publications

  1. ncbi Impact of subclinical chorioamnionitis on maternal and neonatal outcomes
    Ken Miyazaki
    Department of Obstetrics and Gynecology, Japanese Red Cross Nagoya First Hospital, Nagoya 453 8511, Japan
    Acta Obstet Gynecol Scand 86:191-7. 2007
  2. ncbi Preterm premature rupture of membranes and neonatal outcome prior to 34 weeks of gestation
    H M Tanir
    Department of Obstetrics and Gynecology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey
    Int J Gynaecol Obstet 82:167-72. 2003
  3. ncbi Chorioamnionitis: a multiorgan disease of the fetus?
    M Gantert
    Department of Obstetrics and Gynecology, Klinikum Osnabruck, Osnabruck, Germany
    J Perinatol 30:S21-30. 2010
  4. ncbi Endotoxin induced chorioamnionitis prevents intestinal development during gestation in fetal sheep
    Tim G A M Wolfs
    Department of Surgery, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 4:e5837. 2009
  5. ncbi A fetal response to chorioamnionitis is associated with early survival after preterm birth
    Monica M Lahra
    RPA Newborn Care, Royal Prince Alfred Hospital, and the University of Sydney, Sydney, Australia
    Am J Obstet Gynecol 190:147-51. 2004
  6. ncbi Chorioamnionitis and cerebral palsy: a meta-analysis
    Jobe G Shatrov
    School of Medicine, Sydney, The University of Notre Dame Australia and Cerebral Palsy Institute, Darlinghurst, New South Wales, Australia
    Obstet Gynecol 116:387-92. 2010
  7. ncbi Dose and time response after intraamniotic endotoxin in preterm lambs
    B W Kramer
    Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    Am J Respir Crit Care Med 164:982-8. 2001
  8. ncbi Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns
    Raymond W Redline
    Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Pediatr Dev Pathol 6:435-48. 2003
  9. ncbi Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study
    Rajesh Kumar
    Division of Allergy, Children s Memorial Hospital, Chicago, IL 60614, USA
    J Allergy Clin Immunol 121:878-84.e6. 2008
  10. ncbi Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial
    Kristi L Watterberg
    Division of Neonatology, Department of Pediatrics Neonatology, University of New Mexico School of Medicine, MSC10 5590, Albuquerque, NM 87131 0001, USA
    Pediatrics 114:1649-57. 2004

Research Grants

  1. Bacterial Vaginosis and Spontaneous Abortion
    Deborah Nelson; Fiscal Year: 2004
  2. Postnatal Consequences of Fetal Inflammation
    Alan Jobe; Fiscal Year: 2007
  3. Safety of N-acetylcysteine in Maternal Chorioamnionitis
    Dorothea Jenkins; Fiscal Year: 2009
  4. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
  5. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2006
  6. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2007
  7. Neonatal Resuscitation and Preterm Lung Injury
    Alan Jobe; Fiscal Year: 2007
  8. Type 1 fimbrial variation in E coil 018 k1 h7 virulence
    Scott Weissman; Fiscal Year: 2007
  9. FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
    Lawrence S Prince; Fiscal Year: 2010
  10. Safety of N-acetylcysteine in Maternal Chorioamnionitis
    Dorothea Jenkins; Fiscal Year: 2007

Detail Information

Publications215 found, 100 shown here

  1. ncbi Impact of subclinical chorioamnionitis on maternal and neonatal outcomes
    Ken Miyazaki
    Department of Obstetrics and Gynecology, Japanese Red Cross Nagoya First Hospital, Nagoya 453 8511, Japan
    Acta Obstet Gynecol Scand 86:191-7. 2007
    b>Chorioamnionitis is considered to be one of the main causes of preterm labor and has been associated with an adverse perinatal outcome in preterm infants...
  2. ncbi Preterm premature rupture of membranes and neonatal outcome prior to 34 weeks of gestation
    H M Tanir
    Department of Obstetrics and Gynecology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey
    Int J Gynaecol Obstet 82:167-72. 2003
    ..To investigate the impact of preterm premature rupture of membranes on neonatal outcome...
  3. ncbi Chorioamnionitis: a multiorgan disease of the fetus?
    M Gantert
    Department of Obstetrics and Gynecology, Klinikum Osnabruck, Osnabruck, Germany
    J Perinatol 30:S21-30. 2010
    The bacterial infection of chorion and amnion is a common finding in premature delivery and is referred to as chorioamnionitis. As the mother rarely shows symptoms of a systemic inflammation, the course of chorioamnionitis is frequently ..
  4. ncbi Endotoxin induced chorioamnionitis prevents intestinal development during gestation in fetal sheep
    Tim G A M Wolfs
    Department of Surgery, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 4:e5837. 2009
    b>Chorioamnionitis is the most significant source of prenatal inflammation and preterm delivery...
  5. ncbi A fetal response to chorioamnionitis is associated with early survival after preterm birth
    Monica M Lahra
    RPA Newborn Care, Royal Prince Alfred Hospital, and the University of Sydney, Sydney, Australia
    Am J Obstet Gynecol 190:147-51. 2004
    ..was to determine, in a large preterm cohort (20-34 completed weeks of gestation), the incidence of histologic chorioamnionitis and the incidence of a histologic fetal response to chorioamnionitis (umbilical vasculitis with or without ..
  6. ncbi Chorioamnionitis and cerebral palsy: a meta-analysis
    Jobe G Shatrov
    School of Medicine, Sydney, The University of Notre Dame Australia and Cerebral Palsy Institute, Darlinghurst, New South Wales, Australia
    Obstet Gynecol 116:387-92. 2010
    To examine the relationships between clinical or histological chorioamnionitis and cerebral palsy using a meta-analysis approach.
  7. ncbi Dose and time response after intraamniotic endotoxin in preterm lambs
    B W Kramer
    Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    Am J Respir Crit Care Med 164:982-8. 2001
    Intraamniotic endotoxin causes chorioamnionitis, which is followed by improved fetal lung function after 4 d in fetal sheep. We evaluated 0.1 mg, 1 mg, 4 mg, and 10 mg endotoxin for inflammation and lung maturation effects after 7 d...
  8. ncbi Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns
    Raymond W Redline
    Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Pediatr Dev Pathol 6:435-48. 2003
    ..6, substantial. Kappa values for the 12 lesions evaluated in 20 cases by the six pathologists were: acute chorioamnionitis/maternal inflammatory response (any, 0.93; severe 0.76; advanced stage, 0...
  9. ncbi Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study
    Rajesh Kumar
    Division of Allergy, Children s Memorial Hospital, Chicago, IL 60614, USA
    J Allergy Clin Immunol 121:878-84.e6. 2008
    Prematurity (< 37 weeks) has been inconsistently associated with asthma and wheezing. Chorioamnionitis may promote both prematurity and inflammatory pathways in infants' airways.
  10. ncbi Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial
    Kristi L Watterberg
    Division of Neonatology, Department of Pediatrics Neonatology, University of New Mexico School of Medicine, MSC10 5590, Albuquerque, NM 87131 0001, USA
    Pediatrics 114:1649-57. 2004
    ..A pilot study of low-dose hydrocortisone therapy for prophylaxis of early adrenal insufficiency showed improved survival without BPD at 36 weeks' postmenstrual age, particularly in infants exposed to histologic chorioamnionitis.
  11. ncbi Clinical chorioamnionitis, elevated cytokines, and brain injury in term infants
    Lina F Shalak
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9063, USA
    Pediatrics 110:673-80. 2002
    ..To determine the initial inflammatory cytokine response in term infants born to mothers with clinical chorioamnionitis and to assess whether the cytokine response is associated with birth depression, abnormal neurologic ..
  12. ncbi Intra-amniotic endotoxin: chorioamnionitis precedes lung maturation in preterm lambs
    S G Kallapur
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 280:L527-36. 2001
    ....
  13. ncbi Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection
    Mi Jeong Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Lab Invest 89:924-36. 2009
    Acute chorioamnionitis is a response to amniotic fluid (AF) infection...
  14. ncbi Inflammation and bronchopulmonary dysplasia
    Christian P Speer
    University Children s Hospital, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Semin Neonatol 8:29-38. 2003
    ....
  15. ncbi Planned early birth versus expectant management for women with preterm prelabour rupture of membranes prior to 37 weeks' gestation for improving pregnancy outcome
    Sarah L Buchanan
    Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, New South Wales, Australia, 2065
    Cochrane Database Syst Rev 3:CD004735. 2010
    ..32, 95% CI 1.33 to 4.07), but that early delivery had no effect on chorioamnionitis (RR 0.44, 95% CI 0.17 to 1.14)...
  16. ncbi Chorioamnionitis and cerebral palsy in term and near-term infants
    Yvonne W Wu
    Department of Neurology, University of California, San Francisco 94143, USA
    JAMA 290:2677-84. 2003
    Half of all cases of cerebral palsy (CP) occur in term infants, for whom risk factors have not been clearly defined. Recent studies suggest a possible role of chorioamnionitis.
  17. ncbi Effect of chorioamnionitis on early childhood asthma
    Darios Getahun
    Department of Research and Evaluation, Kaiser Permanente Southern California Medical Group, 100 Los Robles Ave, 2nd Floor, Pasadena, CA 91101, USA
    Arch Pediatr Adolesc Med 164:187-92. 2010
    To examine the association between chorioamnionitis and childhood asthma based on gestational age at birth and race/ethnicity.
  18. ncbi Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Pediatr Dev Pathol 11:15-22. 2008
    ..Recovery of microorganisms from placental parenchyma is associated with histologic inflammation. The same microorganisms responsible for inciting high-grade chorionic plate inflammation are also most likely to promote fetal inflammation...
  19. ncbi Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis
    Yeon Mee Kim
    Perinatology Research Branch, National Institute of Child Health and Human Development/NIH/DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 191:1346-55. 2004
    ..Toll-like receptor-2 and -4 expression in fetal membranes in response to labor at term and histologic chorioamnionitis. STUDY DESIGN: Immunohistochemistry and real-time quantitative reverse transcriptase-polymerase chain ..
  20. ncbi Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants
    Tuula Kaukola
    Department of Pediatrics, University of Oulu, FIN-90014 Oulu, Finland
    Pediatr Res 59:478-83. 2006
    ..We investigated the relationship between chorioamnionitis, cord serum cytokines, and neurologic outcome...
  21. ncbi Chorioamnionitis, postnatal factors and proinflammatory response in the pathogenetic sequence of bronchopulmonary dysplasia
    Christian P Speer
    University Children s Hospital, Wurzburg, Germany
    Neonatology 95:353-61. 2009
    ..Pre- and postnatal factors such as chorioamnionitis, oxygen toxicity, mechanical ventilation and postnatal infections can induce and perpetuate an injurious and ..
  22. ncbi The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    Clin Perinatol 37:355-74. 2010
    ..Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap...
  23. ncbi Prenatal inflammation and lung development
    Boris W Kramer
    Department of kindergeneeskunde, Academisch Ziekenhuis Maastricht, Postbus 5800, 6202 AZ Maastricht, The Netherlands
    Semin Fetal Neonatal Med 14:2-7. 2009
    Prenatal exposure of very low birth weight infants to chronic indolent chorioamnionitis with organisms such as mycoplasma and ureaplasma is frequent...
  24. ncbi Prevalence, management, and outcomes of preterm prelabour rupture of the membranes of women in Canada
    Graeme Smith
    Department of Obstetrics and Gynaecology, Queen's University, Kingston, Ontario, Canada
    J Obstet Gynaecol Can 27:547-53. 2005
    ..3%. Overall, 53% of placentas submitted for histopathology after PPROM demonstrated evidence of chorioamnionitis. In the retrospective chart review, we found 153 cases of confirmed PPROM from January 1999 to December 2001,..
  25. ncbi Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants
    Linda J Van Marter
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Pediatr 140:171-6. 2002
    OBJECTIVE: This case-control study of chronic lung disease (CLD) evaluated the hypothesis that chorioamnionitis promotes CLD and interacts with other risk factors for CLD, including mechanical ventilation and postnatal infection...
  26. ncbi MMP-9 and TIMP-1 in the cord blood of premature infants developing BPD
    Shinnosuke Fukunaga
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Pediatr Pulmonol 44:267-72. 2009
    ..030, respectively). The MMP-9 levels and MMP-9/TIMP-1 ratios correlated with the severity of maternal chorioamnionitis (both trend P = 0.006)...
  27. ncbi The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor
    Seung Mi Lee
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    J Matern Fetal Neonatal Med 24:37-42. 2011
    To examine the frequency and risk factors of funisitis and histologic chorioamnionitis in the placentas of term pregnant women who delivered after the spontaneous onset of labor.
  28. ncbi The importance of intra-amniotic inflammation in the subsequent development of atypical chronic lung disease
    Joonho Lee
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Matern Fetal Neonatal Med 22:917-23. 2009
    ..To examine whether the intra-amniotic inflammation is a risk factor for the development of atypical chronic lung disease (CLD)...
  29. ncbi Regulation of interleukin-6 expression in human decidual cells and its potential role in chorioamnionitis
    Charles J Lockwood
    Department of Obstetrics, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Am J Pathol 177:1755-64. 2010
    b>Chorioamnionitis frequently precedes both genital tract and placental inflammation and is both a primary cause of maternal morbidity and a major antecedent of preterm premature rupture of the membranes (PPROM) as well as preterm delivery (..
  30. ncbi Chorioamnionitis and the prognosis for term infants
    J M Alexander
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Obstet Gynecol 94:274-8. 1999
    To assess the effects of clinical chorioamnionitis and labor complications on short-term neonatal morbidity, including seizures.
  31. ncbi Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis
    J V Been
    Department of Paediatrics, Maastricht University Medical Centre, The Netherlands
    BJOG 118:113-22. 2011
    There is debate concerning the safety and efficacy of antenatal steroids in preterm labour with suspected intrauterine infection (chorioamnionitis).
  32. ncbi Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function at school age in extremely low birth weight infants (<1 kg)
    Raymond W Redline
    Department of Pathology, Case School of Medicine and Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Pediatr Dev Pathol 10:282-92. 2007
    ..Histologic chorioamnionitis (HCA) was not predictive of outcome in the population as a whole, but a severe fetal vascular response was ..
  33. ncbi Chorioamnionitis and pregnancy outcome in HIV-infected African women. Pregnancy and HIV Study Group
    J Ladner
    Medical Information Unit, Centre Hospitalier de Kigali, Rwanda
    J Acquir Immune Defic Syndr Hum Retrovirol 18:293-8. 1998
    To assess the role of chorioamnionitis (CAM) on pregnancy outcome in HIV-1-infected (HIV-positive) pregnant women, treated for sexually transmitted diseases (STDs), during the last trimester of pregnancy in Kigali, Rwanda.
  34. ncbi Fetal thymus size as a predictor of chorioamnionitis in women with preterm premature rupture of membranes
    Y Yinon
    Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ultrasound Obstet Gynecol 29:639-43. 2007
    Emerging evidence indicates that chorioamnionitis is associated with a significant decrease in thymic size at birth in very low birth weight (VLBW) preterm infants...
  35. ncbi C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis
    B H Yoon
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Laboratory of Fetal Medicine Research, Clinical Research Institute, Seoul, Korea
    J Matern Fetal Neonatal Med 14:85-90. 2003
    ..69%, p < 0.05; 83% vs. 76%, p < 0.01). CONCLUSION: Umbilical cord plasma CRP concentrations were elevated in patients with amniotic fluid infection, congenital neonatal sepsis and funisitis...
  36. ncbi Preterm histologic chorioamnionitis: impact on cord gas and pH values and neonatal outcome
    Bryan S Richardson
    Department of Obstetrics and Gynaecology, St Joseph s Health Care, University of Western Ontario, London, Ontario, Canada
    Am J Obstet Gynecol 195:1357-65. 2006
    The purpose of this study was to further delineate the impact of preterm chorioamnionitis on a spectrum of neonatal outcomes using a large tertiary hospital population.
  37. ncbi Chronic chorioamnionitis displays distinct alterations of the amniotic fluid proteome
    Giovanna Ogge
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    J Pathol 223:553-65. 2011
    Acute chorioamnionitis of infectious origin and chronic chorioamnionitis of immunological origin are two major placental lesions of spontaneous preterm birth with elevated amniotic fluid interleukin-6 and CXCL10 concentrations, ..
  38. ncbi Chorioamnionitis induced by intraamniotic lipopolysaccharide resulted in an interval-dependent increase in central nervous system injury in the fetal sheep
    A W Danilo Gavilanes
    Department of Pediatrics Neonatology, University Hospital Maastricht, in collaboration with the Research Institute of Growth and Development GROW, Maastricht, The Netherlands
    Am J Obstet Gynecol 200:437.e1-8. 2009
    We quantified the impact of chorioamnionitis on both the white and gray matter structures of the preterm ovine central nervous system (CNS).
  39. ncbi Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating fetal interleukin-6 serum concentration
    K Shimoya
    Department of Obstetrics and Gynecology, Faculty of Medicine Osaka University, Suita City, Japan
    Hum Reprod 15:2234-40. 2000
    ..The interleukin-6 (IL-6) titre in cord sera of RDS-free neonates born to mothers with histological chorioamnionitis was significantly higher than that in RDS-complicated neonates without chorioamnionitis...
  40. ncbi Hemodynamic disturbances in premature infants born after chorioamnionitis: association with cord blood cytokine concentrations
    Toby Debra Yanowitz
    Department of Pediatrics, Division of Neonatology, University of Pittsburgh School of Medicine and the Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Pediatr Res 51:310-6. 2002
    b>Chorioamnionitis and elevated cord blood inflammatory cytokine concentrations are associated with detectable disturbances of systemic and cerebral hemodynamics in premature newborns. Fifty-five infants (25-31 wk gestation) were enrolled...
  41. ncbi Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndrome
    Sun Kwon Kim
    Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinat Med 37:543-52. 2009
    ..The aim of this study was to determine whether fetal and maternal granulocytes and monocytes have the phenotypic and metabolic characteristics of activation in cases with FIRS...
  42. ncbi Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1
    Roberto Romero
    Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 24:1444-55. 2011
    ..intra-amniotic infection/inflammation (IAI) is associated with changes in amniotic fluid concentrations of HMGB1; and (2) localize immunoreactivity of HMGB1 in the fetal membranes and umbilical cord of patients with chorioamnionitis.
  43. ncbi Histologic chorioamnionitis is more common after spontaneous labor than after induced labor at term
    H S Park
    Department of Obstetrics and Gynecology, Graduate School of Medicine, Dongguk University, Seoul, South Korea
    Placenta 31:792-5. 2010
    Inflammation of the chorioamniotic membranes (histologic chorioamnionitis) is a risk factor for adverse neonatal outcome...
  44. ncbi Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep
    Steffen Kunzmann
    University Children s Hospital, Wurzburg, Germany
    Am J Obstet Gynecol 202:476.e1-9. 2010
    ..We asked whether fetal inflammation caused by chorioamnionitis would modulate thymus development.
  45. ncbi Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery
    Brenna L Anderson
    Division of Reproductive Infectious Diseases and Immunology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Obstet Gynecol 196:524.e1-5. 2007
    ..The objective of the study was to determine the frequency of adverse pregnancy outcomes in women with untreated asymptomatic group B beta-hemolytic streptococcal (GBS) bacteriuria during pregnancy...
  46. ncbi Minimal lung and systemic responses to TNF-alpha in preterm sheep
    Machiko Ikegami
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L121-9. 2003
    TNF-alpha has been associated with chorioamnionitis and the subsequent development of bronchopulmonary dysplasia in preterm infants...
  47. ncbi Umbilical cord blood concentrations of IL-6, IL-8, and MMP-8 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis
    Ctirad Andrys
    Department of Clinical Immunology and Allergy, Charles UniversityPrague, Czech Republic
    Neuro Endocrinol Lett 31:857-63. 2010
    ..interleukin-8 (IL-8), and matrix metalloproteinase-8 (MMP-8) are of value in the diagnosis of histological chorioamnionitis (HCA) and funisitis in patients with preterm premature rupture of membranes (PPROM)...
  48. ncbi Accuracy of C-reactive protein determination in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes: a systematic review
    Rafli van de Laar
    Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 147:124-9. 2009
    ..The aim of this review was to assess whether CRP accurately predicts chorioamnionitis and/or neonatal sepsis in women with PPROM...
  49. ncbi Chorioamnionitis and increased neonatal lung lavage fluid matrix metalloproteinase-9 levels: implications for antenatal origins of chronic lung disease
    Anna E Curley
    Department of Child Health, Queen s University of Belfast, Institute of Clinical Science, Belfast, Northern Ireland
    Am J Obstet Gynecol 188:871-5. 2003
    ..We studied the effects of chorioamnionitis and antenatal corticosteroids on bronchoalveolar lavage (BAL) fluid levels of MMP-9, and its inhibitor, TIMP-..
  50. ncbi Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation
    Si Eun Lee
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    J Matern Fetal Neonatal Med 19:693-7. 2006
    ..CONCLUSION: Funisitis is present in 4% of women at term and is associated with microbial invasion of the amniotic cavity (MIAC) and inflammation as reflected by increased AF WBC count...
  51. ncbi The Alabama Preterm Birth study: polymorphonuclear and mononuclear cell placental infiltrations, other markers of inflammation, and outcomes in 23- to 32-week preterm newborn infants
    William W Andrews
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35233 1602, USA
    Am J Obstet Gynecol 195:803-8. 2006
    ..The purpose of this study was to better understand the relationship between placental polymorphonuclear and mononuclear cell infiltrations with bacterial cultures, markers of inflammation, and preterm outcomes...
  52. ncbi Value of amniotic fluid interleukin-8 for the prediction of histological chorioamnionitis in preterm premature rupture of membranes
    Marian Kacerovsky
    Department of Obstetrics and Gynaecology, Charles University in Prague, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
    Neuro Endocrinol Lett 30:733-8. 2009
    To determine whether amniotic fluid levels of interleukin-8 (IL-8) are of value in the antenatal diagnosis of acute histological chorioamnionitis (HCA) in preterm premature rupture of membranes (PPROM).
  53. ncbi The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth
    Chong Jai Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Mod Pathol 23:1000-11. 2010
    Acute chorioamnionitis is a well-established lesion of the placenta in cases with intra-amniotic infection. In contrast, the clinicopathological significance of chronic chorioamnionitis is unclear...
  54. ncbi Neonatal morbidity and placental pathology
    Rajeev Mehta
    Department of Pediatrics, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    Indian J Pediatr 73:25-8. 2006
    ..To investigate the association between gestational age, placental pathology and outcome among preterm births...
  55. ncbi Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes
    Patrick S Ramsey
    Division of Maternal Fetal Medicine, Department of Obstetrics Gynecology, 458 Old Hillman Building, 619 19th St South, Birmingham, AL, USA
    Am J Obstet Gynecol 192:1162-6. 2005
    To compare morbidities of neonates born to women who developed chorioamnionitis after premature preterm rupture of membranes versus those who did not.
  56. ncbi Special relationships between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates
    Robert Mittendorf
    Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL 60153, USA
    J Perinat Med 33:428-34. 2005
    ....
  57. ncbi Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease
    Mi Jeong Kim
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 and Detroit, MI 48201, USA
    J Immunol 182:3919-27. 2009
    ..In contrast to acute chorioamnionitis of infection-related origin, the fundamental immunopathology of VUE is unknown...
  58. ncbi Puerperal adrenal abscess complicating chorioamnionitis
    R Eitan
    Obstetrics and Gynecology, Shaare Zedek Medical Center, Ben-Gurion University of the Negev, Jerusalem, Israel
    Obstet Gynecol 99:909-11. 2002
    ..We present a case report of chorioamnionitis complicated by a puerperal adrenal abscess diagnosed and drained percutaneously using ultrasound and computed ..
  59. ncbi Diagnosis and management of clinical chorioamnionitis
    Alan T N Tita
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Alabama at Birmingham, 619 19th South, Birmingham, AL 3524, USA
    Clin Perinatol 37:339-54. 2010
    b>Chorioamnionitis is a common complication of pregnancy associated with significant maternal, perinatal, and long-term adverse outcomes...
  60. ncbi The severity of chorioamnionitis in pregnant sheep is associated with in vivo variation of the surface-exposed multiple-banded antigen/gene of Ureaplasma parvum
    Christine L Knox
    Institute of Health and Biomedical Innovation, and School of Life Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    Biol Reprod 83:415-26. 2010
    ..005), and ureaplasma titers were inversely related to the number of variants (P = 0.025). The severity of chorioamnionitis varied between animals...
  61. ncbi Intrauterine infection may be a major cause of stillbirth in Sweden
    E Tolockiene
    Department of Pathology, University of Lund, Lund, Sweden
    Acta Obstet Gynecol Scand 80:511-8. 2001
    AIM OF THE STUDY: To investigate intrauterine infection as a cause for unexplained stillbirth. METHODS: Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden...
  62. ncbi Interleukin-1beta in the bronchoalveolar lavage fluid of premature neonates: a marker for maternal chorioamnionitis and predictor of adverse neonatal outcome
    R G Cayabyab
    Division of Neonatology and Allergy/Immunology, Department of Pediatrics, Women's and Children's Hospital, LAC and USC Medical Center, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    J Matern Fetal Neonatal Med 14:205-11. 2003
    ..initial tracheal aspirate positive for IL-1beta had a highly significant correlation with documented maternal chorioamnionitis for the given patient...
  63. ncbi Maternal versus fetal inflammation and respiratory distress syndrome: a 10-year hospital cohort study
    M M Lahra
    Department of Neonatal Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Arch Dis Child Fetal Neonatal Ed 94:F13-6. 2009
    To determine the impact of maternal and fetal intrauterine inflammatory responses (chorioamnionitis and umbilical vasculitis) on the development of neonatal respiratory distress syndrome (RDS) in preterm infants.
  64. ncbi Meconium-stained amniotic fluid and neonatal morbidity in near-term and term deliveries with acute histologic chorioamnionitis and/or funisitis
    S Rao
    University of Southern California Keck School of Medicine, Department of Pediatrics, Division of Neonatology, Women's and Children's Hospital, 1240 North Mission Road, Los Angeles, CA 90033, USA
    J Perinatol 21:537-40. 2001
    ..amniotic fluid (MSAF) and neonatal morbidity in near-term and term deliveries with histologic acute chorioamnionitis and/or funisitis compared to those with normal placental histology...
  65. ncbi Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome?
    Wolfgang Thomas
    University Children s Hospital Wurzburg, Wurzburg, Germany
    Neonatology 99:177-87. 2011
    b>Chorioamnionitis as a major risk factor for spontaneous preterm birth, especially at earlier gestational ages, contributes to prematurity-associated mortality and morbidity...
  66. ncbi Maternal and fetal inflammatory responses in unexplained fetal death
    S Blackwell
    Department of Obstetrics and Gynecology, Wayne State University/Hutzel Hospital, Detroit, Michigan, 48201, USA
    J Matern Fetal Neonatal Med 14:151-7. 2003
    ..Histological examination of the placenta was conducted to identify a maternal inflammatory response (acute chorioamnionitis) or a fetal inflammatory response (funisitis)...
  67. ncbi Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns
    Francesca Moscuzza
    Neonatology and Neonatal Intensive Care Unit, Department of Pediatrics, S Chiara Hospital University of Pisa, Italy
    Gynecol Endocrinol 27:319-23. 2011
    ..Placental anatomopathologic lesions are usually associated with pregnancy complications and neonatal impaired outcome...
  68. ncbi Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis
    Michela Torricelli
    Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, 53100, Siena, Italy
    J Clin Endocrinol Metab 96:534-40. 2011
    ..The pathogenesis of preterm delivery (PTD) is not clear, although inflammation/infection play a major role. Corticotropin releasing-hormone (CRH) and Urocortins (Ucns) are involved in the pathophysiology of PTD...
  69. ncbi Facklamia hominis causing chorioamnionitis and puerperal bacteraemia
    B Healy
    Microbiology Cardiff, NPHS Wales, UHW, Heath Park, Cardiff CF14 4XW, UK
    J Infect 50:353-5. 2005
  70. ncbi Chorioamnionitis: a risk factor for fetal and neonatal morbidity
    Rodolfo Bracci
    Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Italy
    Biol Neonate 83:85-96. 2003
    ..Proxies of intrauterine infection include clinical chorioamnionitis, histological chorioamnionitis and intraamniotic increase in cytokines, which have been found to be ..
  71. ncbi Endotoxin-induced chorioamnionitis modulates innate immunity of monocytes in preterm sheep
    Boris W Kramer
    University Children s Hospital, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Am J Respir Crit Care Med 171:73-7. 2005
    ..Although the preterm fetus is frequently exposed to chorioamnionitis, the effects of exposure of the fetal lung to inflammation on innate immune responses are unknown...
  72. ncbi Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs
    Steffen Kunzmann
    Department of Pediatrics, Academisch Ziekenhuis Maastricht, Postbus 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 292:L223-31. 2007
    b>Chorioamnionitis is frequently associated with preterm birth and increases the risk of adverse outcomes such as bronchopulmonary dysplasia (BPD)...
  73. ncbi High compared with standard gentamicin dosing for chorioamnionitis: a comparison of maternal and fetal serum drug levels
    Gregory J Locksmith
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Obstet Gynecol 105:473-9. 2005
    To compare umbilical cord and maternal serum peak gentamicin concentration, gentamicin elimination, and clinical outcomes between women who received once-daily compared with standard, thrice-daily dosing for clinical chorioamnionitis.
  74. ncbi Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis
    A P Murtha
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
    Infect Dis Obstet Gynecol 10:93-6. 2002
    ..The objective of this investigation was to determine if apoptosis was increased in the chorion laeve of term patients with and without histologic chorioamnionitis.
  75. ncbi Increase of interleukin-6 in tracheal aspirate at birth: a predictor of subsequent bronchopulmonary dysplasia in preterm infants
    Chang Won Choi
    Clinical Research Institute, Seoul National University Bundang Hospital, Gyeonggi-do, Korea
    Acta Paediatr 95:38-43. 2006
    ..CONCLUSION: IL-6 in TA at birth can be used as a predictor of BPD in combination with the presence of PDA...
  76. ncbi Methicillin-resistant Staphylococcus aureus bacteremia and chorioamnionitis after recurrent marsupialization of a bartholin abscess
    David M Sherer
    Department of Obstetrics and Gynecology, the Division of Maternal Fetal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
    Obstet Gynecol 114:471-2. 2009
    Methicillin-resistant Staphylococcus aureus (MRSA) is an extremely rare etiology of chorioamnionitis.
  77. ncbi Efficacy of ciprofloxacin in an experimental model of Escherichia coli chorioamnionitis in rabbits
    Elise Launay
    Departement de Perinatologie, Hôpital Mère Enfant CHU Nantes, Nantes Cedex 1, France
    Antimicrob Agents Chemother 53:1624-7. 2009
    Pregnant rabbits were treated with ciprofloxacin alone or with gentamicin in a model of Escherichia coli chorioamnionitis, and the results were compared with those for untreated rabbits...
  78. ncbi Histological chorioamnionitis and respiratory outcome in preterm infants
    J V Been
    Department of Paediatrics, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Arch Dis Child Fetal Neonatal Ed 94:F218-25. 2009
    ..Initial reports suggest that in preterm infants histological chorioamnionitis is associated with a decreased incidence of respiratory distress syndrome (RDS), while the incidence of ..
  79. ncbi The frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor
    Hyo Suk Seong
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Am J Obstet Gynecol 199:375.e1-5. 2008
    ..presence and progress of labor are associated with an increased risk of microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation, and histologic chorioamnionitis in women with term pregnancies with intact membranes.
  80. ncbi Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitis
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Obstet Gynecol 111:403-12. 2008
    To estimate the relationship between histologic chorioamnionitis and four amniotic fluid proteomic biomarkers characteristic of inflammation (defensins 2 and 1, calgranulins C and A).
  81. ncbi Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    J Immunol 179:8491-9. 2007
    In a model of human chorioamnionitis, fetal sheep exposed to a single injection, but not repeated injections, of intra-amniotic endotoxin develop lung injury responses...
  82. ncbi Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis
    Rose Marie Holst
    Department of Obstetrics and Gynecology, Perinatal Center, Institute for Clinical Sciences, Sahlgrenska Academy, East Hospital, Goteborg, Sweden
    J Matern Fetal Neonatal Med 20:885-93. 2007
    To correlate cervical and amniotic fluid cytokines and macrophage-related chemokines to the development of histological chorioamnionitis (HCA) in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PPROM).
  83. ncbi Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery
    Ceyda Oner
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 93:252-9. 2008
    b>Chorioamnionitis (CAM)-elicited preterm delivery (PTD) is associated with elevated amniotic fluid levels of IL-1beta and TNF-alpha...
  84. ncbi Acute and chronic chorioamnionitis and the risk of perinatal human immunodeficiency virus-1 transmission
    Benjamin H Chi
    School of Medicine, University of Alabama, Birmingham, AL 35294 0024, USA
    Am J Obstet Gynecol 194:174-81. 2006
    This study was undertaken to examine the prevalence of acute and chronic chorioamnionitis among women infected with human immunodeficiency virus-1 (HIV-1) and to determine the relative contribution of each to perinatal HIV-1 transmission.
  85. ncbi Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis
    Tushar A Shah
    Divisions of Neonatology and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Res 68:210-5. 2010
    ..MCP-1 and MCP-2) mediate monocyte and T-lymphocyte chemotaxis, and IL-1 contributes to the pathogenesis of chorioamnionitis-induced lung inflammation and fetal inflammatory responses...
  86. ncbi Risk factors for neonatal intraventricular haemorrhage in spontaneous prematurity at 32 weeks gestation or less
    P Vergani
    Department of Obstetrics and Gynecology, Istituto di Scienze Biomediche San Gerardo, Monza, Italy
    Placenta 21:402-7. 2000
    ..at delivery, cord pH at birth, rates of 5-min Apgar score below 7, caesarean delivery, diagnosis of clinical chorioamnionitis or antenatal administration of steroids...
  87. ncbi Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis
    Kaori Kumazaki
    Department of Molecual Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan
    Hum Pathol 35:47-54. 2004
    ..Hofbauer cells of all preterm and term placentas examined and to the inflammatory cells in placentas with chorioamnionitis (CAM)...
  88. ncbi Chorioamnionitis: elevated interleukin-6 and interleukin-8 concentrations in the lower uterine segment
    Marc J Willi
    Department of Obstetrics and Gynecology, Technical University (RWTH) of Aachen, Aachen, Germany
    J Perinat Med 30:292-6. 2002
    AIMS: To determine interleukin (IL)-6 and IL-8 concentrations in the lower uterine segment in patients with chorioamnionitis compared to those without...
  89. ncbi Increased apoptosis of human fetal membranes in rupture of the membranes and chorioamnionitis
    S Kataoka
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku N15 W7, Sapporo 060-8638, Japan
    Placenta 23:224-31. 2002
    ..The aim of this study was to assess apoptosis of the amnion and the chorion in relation to ROM and chorioamnionitis (CAM)...
  90. ncbi Regulation of FasL/Fas in human trophoblasts: possible implications for chorioamnionitis
    Dhruv R Balkundi
    Department of Pediatrics, Division of Neonatology and Developmental Biology, University of Pittsburgh, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Biol Reprod 69:718-24. 2003
    b>Chorioamnionitis is a common cause of premature birth and is associated with significant morbidity and mortality in the mother and infant...
  91. ncbi Re-evaluation of chorioamnionitis and funisitis with a special reference to subacute chorioamnionitis
    Makiko Ohyama
    Division of Neonatology, Obstetrics, and Pathology, Kanagawa Children's Medical Center, Yokohama City, Japan
    Hum Pathol 33:183-90. 2002
    Our purpose is to prove that prolonged inflammation of the chorionic plate, which we have termed subacute chorioamnionitis (SCAM), is a distinctive entity and should be differentiated from acute chorioamnionitis (ACAM) because it is an ..
  92. ncbi Antibiotic administration to patients with preterm premature rupture of membranes does not eradicate intra-amniotic infection
    Ricardo Gomez
    Center for Perinatal Diagnosis and Research CEDIP, Hospital Dr Sotero del Rio, P Universidad Catolica de Chile, Puente Alto, Chile
    J Matern Fetal Neonatal Med 20:167-73. 2007
    ....
  93. ncbi Value of placental microbial evaluation in diagnosing intra-amniotic infection
    Christian M Pettker
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Obstet Gynecol 109:739-49. 2007
    ..To evaluate the ability of microbiologic and pathologic examination of the placenta to accurately diagnose intraamniotic infection and inflammation...
  94. ncbi Relationship of amniotic-type placenta inflammation to pPROM, PROM and risk of early onset neonatal sepsis
    Milos Veleminsky
    Department of Obstetrics and Gynaecology, Hospital Ceske Budejovice, Czech Republic
    Neuro Endocrinol Lett 29:447-50. 2008
    ..PROM and pPROM and early onset neonatal sepsis negatively affect the neonatal perinatal mortality and morbidity...
  95. ncbi Myelopoiesis in the liver of stillborns with evidence of intrauterine infection
    Roberto N Miranda
    Department of Pathology, University of Missouri Kansas City, Truman Medical Center, 2301 Holmes St, Kansas City, MO 64108, USA
    Arch Pathol Lab Med 130:1786-91. 2006
    b>Chorioamnionitis is the maternal and fetal response to an ascending intrauterine infection. The fetal response is manifested by funisitis and chorionic vasculitis, or as neutrophils within pulmonary spaces...
  96. ncbi Pre-term pre-labour rupture of membranes: effect of chorioamnionitis on overall neonatal outcome
    V O Oboro
    Department of Obstetrics and Gynaecology, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Osun State, Nigeria
    J Obstet Gynaecol 26:740-3. 2006
    Our objective was to evaluate the association between clinical chorioamnionitis following preterm pre-labour rupture of membranes (PPROM) and adverse neonatal outcome...
  97. ncbi Premature rupture of the membranes: an evidence-based approach to clinical care
    C S Naylor
    Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Cedars-Sinai Medical Center, Burns and Allen Research Institute, Los Angeles, California, USA
    Am J Perinatol 18:397-413. 2001
    ..This review will address the important questions concerning the management of premature rupture of membranes and will attempt to provide comprehensive answers as they appear in the medical literature...
  98. ncbi The relationship between placental histopathology findings and perinatal outcome in preterm infants
    D Ogunyemi
    Morristown Memorial Hospital, New Jersey, USA
    J Matern Fetal Neonatal Med 13:102-9. 2003
    ..neonates delivered at 24-32 weeks between 1992 and 2000 was classified as follows: 254 (33%) had histological chorioamnionitis, 263 (34%) had coagulation-related lesions, 228 (30%) had vasculopathy...
  99. ncbi Amnionitis with Ureaplasma urealyticum or other microbes leads to increased morbidity and prolonged hospitalization in very low birth weight infants
    Lieselotte Kirchner
    Department of Neonatology and Intensive Care, University Hospital of Pediatrics, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 134:44-50. 2007
    ..To investigate the influence of culture proven intrauterine infection on preterm morbidity and to test the effect of antimicrobial treatment...
  100. ncbi Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction
    S Offenbacher
    Center for Oral and Systemic Diseases, Departments of Periodontology and Dental Ecology, University of North Carolina at Chapel Hill, School of Dentistry, Chapel Hill, NC, USA
    Ann Periodontol 6:164-74. 2001
    ..BW) adjusting for race, age, food stamp eligibility, marital status, previous preterm births, first birth, chorioamnionitis, bacterial vaginosis, and smoking...
  101. ncbi Microbial invasion of the amniotic cavity at birth is associated with adverse short-term outcome of preterm infants
    Angelika Berger
    Department of Pediatrics, Division of Neonatology, University Hospital Vienna, Austria
    J Perinat Med 31:115-21. 2003
    ..To determine the frequency and clinical significance of microbial invasion of the amniotic cavity at the time of delivery in preterm infants...

Research Grants80

  1. Bacterial Vaginosis and Spontaneous Abortion
    Deborah Nelson; Fiscal Year: 2004
    ..associations between BV and late pregnancy outcomes; such as, preterm labor, premature rupture of membrane, chorioamnionitis, and low birth weight. The impact of BV on the risk for spontaneous abortion (SAB) is unclear...
  2. Postnatal Consequences of Fetal Inflammation
    Alan Jobe; Fiscal Year: 2007
    ..The majority of very low birth weight preterm infants are exposed to chronic indolent chorioamnionitis (inflammation) that can alter lung development and result in bronchopulmonary dysplasia...
  3. Safety of N-acetylcysteine in Maternal Chorioamnionitis
    Dorothea Jenkins; Fiscal Year: 2009
    ..N-acetylcysteine (NAC) is a promising therapy that has shown effective neuroprotection in the animal model of chorioamnionitis, and has a favorable safety profile with known side effects, which appear to be limited and manageable...
  4. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
    Clinically overt infection of the placenta, fetal membranes, or uterus during labor (chorioamnionitis) complicates from 1% to 11% of pregnancies...
  5. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2006
    ..role of increased antigenic stimulation from lower genital tract infection as a determinant of endometritis, chorioamnionitis and preterm birth among African American and white women. 2...
  6. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2007
    ..g., chorioamnionitis) with no symptoms or who have presentations that are considered equivocal, and 2) infants with respiratory ..
  7. Neonatal Resuscitation and Preterm Lung Injury
    Alan Jobe; Fiscal Year: 2007
    ..The majority of infants with birth weights <1 kg have been exposed to chorioamnionitis, which causes lung inflammation and alters innate inflammatory responses...
  8. Type 1 fimbrial variation in E coil 018 k1 h7 virulence
    Scott Weissman; Fiscal Year: 2007
    ..Such a test might ultimately be used to identify women at increased risk of chorioamnionitis and pre-term labor, or of delivering infected newborns...
  9. FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
    Lawrence S Prince; Fiscal Year: 2010
    ..Prenatal exposure to chorioamnionitis (inflammation of the maternal membranes, placenta, and uterus) increases the risk of bronchopulmonary ..
  10. Safety of N-acetylcysteine in Maternal Chorioamnionitis
    Dorothea Jenkins; Fiscal Year: 2007
    ..N-acetylcysteine (NAC) is a promising therapy that has shown effective neuroprotection in the animal model of chorioamnionitis, and has a favorable safety profile with known side effects, which appear to be limited and manageable...
  11. FGF-10 Expression in a Fetal Mouse Lung Model of Bronchopulmonary Dysplasia
    LAWRENCE PRINCE; Fiscal Year: 2009
    ..Prenatal exposure to chorioamnionitis (inflammation of the maternal membranes, placenta, and uterus) increases the risk of bronchopulmonary ..
  12. Consequences of redox imbalance in preterm parturition
    Irina Buhimschi; Fiscal Year: 2003
    Both intrauterine (e.g. chorioamnionitis) and various matemal systemic infections are proposed causes of preterm labor triggered by a protective inflammatory response (based on the finding of elevated cytokines) that becomes maladaptive ..
  13. HIV, Malaria and Neurobehavioral Development in Early Childhood
    Penny Holding; Fiscal Year: 2007
    ..are mediated by pre-term birth, intrauterine growth retardation (IUGR) and placenta! abnormalities, including chorioamnionitis. LBW and placenta! abnormalities, in turn, lead to developmental delays and to a slowed rate of development ..
  14. HIV, Malaria and Neurobehavioral Development in Early Childhood
    Penny A Holding; Fiscal Year: 2010
    ..are mediated by pre-term birth, intrauterine growth retardation (IUGR) and placenta! abnormalities, including chorioamnionitis. LBW and placenta! abnormalities, in turn, lead to developmental delays and to a slowed rate of development ..