normal pressure hydrocephalus

Summary

Summary: A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see GAIT DISORDERS, NEUROLOGIC), progressive intellectual decline, and URINARY INCONTINENCE. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of CSF including SUBARACHNOID HEMORRHAGE, chronic MENINGITIS, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)

Top Publications

  1. ncbi Predictors of outcome in patients with normal-pressure hydrocephalus
    Ullrich Meier
    Department of Neurosurgery, Unfallkrankenhaus Berlin, Warener Strasse 7, DE 12683 Berlin, Germany
    Eur Neurol 51:59-67. 2004
  2. ncbi Intracranial pulse pressure amplitude levels determined during preoperative assessment of subjects with possible idiopathic normal pressure hydrocephalus
    P K Eide
    Department of Neurosurgery, The National Hospital, Rikshospitalet, Oslo, Norway
    Acta Neurochir (Wien) 148:1151-6; discussion 1156. 2006
  3. ncbi CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus
    A Agren-Wilsson
    Department of Clinical Neuroscience, Umea University, Umea, Sweden
    Acta Neurol Scand 116:333-9. 2007
  4. ncbi Analysis of potential diagnostic biomarkers in cerebrospinal fluid of idiopathic normal pressure hydrocephalus by proteomics
    X Li
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Acta Neurochir (Wien) 148:859-64; discussion 864. 2006
  5. ncbi Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus
    Ming Jen Lee
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 4:e7868. 2009
  6. ncbi Value of quantitative MRI biomarkers (Evans' index, aqueductal flow rate, and apparent diffusion coefficient) in idiopathic normal pressure hydrocephalus
    Samuel E S Ng
    Department of Radiology, Mount Elizabeth Hospital, Singapore
    J Magn Reson Imaging 30:708-15. 2009
  7. ncbi The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus: can co-morbidity with other forms of dementia be excluded?
    Grant A Bateman
    Department of Medical Imaging, John Hunter Hospital, Locked Bag 1, Newcastle Region Mail Centre, Newcastle, 2310, Australia
    Neuroradiology 47:741-8. 2005
  8. ncbi Changes in intracranial pulse pressure amplitudes after shunt implantation and adjustment of shunt valve opening pressure in normal pressure hydrocephalus
    Per Kristian Eide
    Department of Neurosurgery, Division of Clinical Neuroscience, The National Hospital Rikshospitalet, 0027, Oslo, Norway
    Acta Neurochir (Wien) 150:1141-7; discussion 1147. 2008
  9. ncbi Measurement of cerebrospinal fluid flow at the cerebral aqueduct by use of phase-contrast magnetic resonance imaging: technique validation and utility in diagnosing idiopathic normal pressure hydrocephalus
    Patrick H Luetmer
    Department of Diagnostic Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 50:534-43; discussion 543-4. 2002
  10. ncbi Cerebral perfusion pattern of idiopathic normal pressure hydrocephalus studied by SPECT and statistical brain mapping
    Hiroki Sasaki
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji, Hyogo 670 0981, Japan
    Ann Nucl Med 21:39-45. 2007

Research Grants

  1. Cognitive Recovery in Normal Pressure Hydrocephalus
    Heather Katzen; Fiscal Year: 2007
  2. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
  3. Data Mining Based Noninvasive Intracranial Pressure Assessment
    Xiao Hu; Fiscal Year: 2007
  4. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    Anthony Marmarou; Fiscal Year: 2007
  5. "Naturalistic Assessment of the Driving ability of Cognitively Impaired Elders
    Brian Ott; Fiscal Year: 2007
  6. A LONGITUDINAL STUDY OF HAZARDOUS DRIVERS WITH DEMENTIA
    Brian Ott; Fiscal Year: 2004
  7. Neural Basis of Unilateral Spatial Neglect
    Argye Hillis; Fiscal Year: 2007
  8. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
  9. 1H MRS markers of MCI syndromes and common dementias
    Kejal Kantarci; Fiscal Year: 2007
  10. Neural bases of empathy and prosody
    Argye E Hillis; Fiscal Year: 2010

Detail Information

Publications184 found, 100 shown here

  1. ncbi Predictors of outcome in patients with normal-pressure hydrocephalus
    Ullrich Meier
    Department of Neurosurgery, Unfallkrankenhaus Berlin, Warener Strasse 7, DE 12683 Berlin, Germany
    Eur Neurol 51:59-67. 2004
    ..Those 75 patients with a late state NPH (with cerebral atrophy) had a better outcome when dementia was not present, the outflow resistance was >20 mm Hg.min/ml, the CSF tap test was positive and a Miethke Dual-Switch valve was implanted...
  2. ncbi Intracranial pulse pressure amplitude levels determined during preoperative assessment of subjects with possible idiopathic normal pressure hydrocephalus
    P K Eide
    Department of Neurosurgery, The National Hospital, Rikshospitalet, Oslo, Norway
    Acta Neurochir (Wien) 148:1151-6; discussion 1156. 2006
    It was previously reported that the intracranial pulse pressure amplitudes were elevated in idiopathic normal pressure hydrocephalus (iNPH) patients responding to shunt surgery...
  3. ncbi CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus
    A Agren-Wilsson
    Department of Clinical Neuroscience, Umea University, Umea, Sweden
    Acta Neurol Scand 116:333-9. 2007
    ..evaluate cerebrospinal fluid (CSF) markers for neuronal degeneration and demyelination in idiopathic normal pressure hydrocephalus (INPH), subcortical arteriosclerotic encephalopathy (SAE), and neurologically healthy subjects...
  4. ncbi Analysis of potential diagnostic biomarkers in cerebrospinal fluid of idiopathic normal pressure hydrocephalus by proteomics
    X Li
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Acta Neurochir (Wien) 148:859-64; discussion 864. 2006
    The pathogenesis of idiopathic normal pressure hydrocephalus (INPH) is unknown, and the syndrome of INPH remains a diagnostic and therapeutic challenge...
  5. ncbi Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus
    Ming Jen Lee
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 4:e7868. 2009
    ..Normal-pressure hydrocephalus (NPH) is a neurodegenerative disorder that usually occurs late in adult life. Clinically, the cardinal features include gait disturbances, urinary incontinence, and cognitive decline...
  6. ncbi Value of quantitative MRI biomarkers (Evans' index, aqueductal flow rate, and apparent diffusion coefficient) in idiopathic normal pressure hydrocephalus
    Samuel E S Ng
    Department of Radiology, Mount Elizabeth Hospital, Singapore
    J Magn Reson Imaging 30:708-15. 2009
    ..index (EI), aqueductal flow rate (FR), and apparent diffusion coefficient (ADC) in the diagnosis of normal pressure hydrocephalus (NPH) and to assess the ability of these markers preoperatively to predict shunt response...
  7. ncbi The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus: can co-morbidity with other forms of dementia be excluded?
    Grant A Bateman
    Department of Medical Imaging, John Hunter Hospital, Locked Bag 1, Newcastle Region Mail Centre, Newcastle, 2310, Australia
    Neuroradiology 47:741-8. 2005
    Variable results are obtained from the treatment of normal pressure hydrocephalus (NPH) by shunt insertion. There is a high correlation between NPH and the pathology of Alzheimer's disease (AD) on brain biopsy...
  8. ncbi Changes in intracranial pulse pressure amplitudes after shunt implantation and adjustment of shunt valve opening pressure in normal pressure hydrocephalus
    Per Kristian Eide
    Department of Neurosurgery, Division of Clinical Neuroscience, The National Hospital Rikshospitalet, 0027, Oslo, Norway
    Acta Neurochir (Wien) 150:1141-7; discussion 1147. 2008
    We have previously reported that the intracranial pulse pressure amplitudes were elevated in idiopathic normal pressure hydrocephalus (NPH) patients responding to shunt surgery...
  9. ncbi Measurement of cerebrospinal fluid flow at the cerebral aqueduct by use of phase-contrast magnetic resonance imaging: technique validation and utility in diagnosing idiopathic normal pressure hydrocephalus
    Patrick H Luetmer
    Department of Diagnostic Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 50:534-43; discussion 543-4. 2002
    ..fluid (CSF) flow at the cerebral aqueduct and established the range of CSF flows in normal elderly patients, patients with Alzheimer's and other forms of dementia, and patients with idiopathic normal pressure hydrocephalus (NPH).
  10. ncbi Cerebral perfusion pattern of idiopathic normal pressure hydrocephalus studied by SPECT and statistical brain mapping
    Hiroki Sasaki
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji, Hyogo 670 0981, Japan
    Ann Nucl Med 21:39-45. 2007
    To investigate the specific pattern of cerebral blood flow (CBF) in subjects with idiopathic normal pressure hydrocephalus (iNPH) using voxel-based analysis.
  11. ncbi Tau protein is a potential biological marker for normal pressure hydrocephalus
    T Kudo
    Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    Psychiatry Clin Neurosci 54:199-202. 2000
    A biological marker for normal pressure hydrocephalus (NPH) is beneficial for evaluation of its severity and of indications for shunt operation...
  12. ncbi Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients
    Per Kristian Eide
    Division of Clinical Neuroscience, Department of Neurosurgery, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Neurosurgery 66:80-91. 2010
    To review our experience of managing idiopathic normal pressure hydrocephalus (iNPH) during the 6-year period from 2002 to 2007, when intracranial pressure (ICP) monitoring was part of the diagnostic workup.
  13. ncbi The pathophysiology of idiopathic normal pressure hydrocephalus: cerebral ischemia or altered venous hemodynamics?
    G A Bateman
    Department of Medical Imaging, John Hunter Hospital, Newcastle, Australia
    AJNR Am J Neuroradiol 29:198-203. 2008
    Many theories of normal pressure hydrocephalus (NPH) stress the importance of ischemia in the deep white matter. Alternate theories stress a reduction in superficial venous compliance and changes in pulse-wave propagation...
  14. ncbi Guidelines for management of idiopathic normal pressure hydrocephalus
    Masatsune Ishikawa
    Kitano Hospital, Japan
    Neurol Med Chir (Tokyo) 48:S1-23. 2008
    ..disorders manifesting dementia, gait disturbance, and urinary incontinence in the elderly population, normal pressure hydrocephalus (NPH), especially of idiopathic type (iNPH), is becoming noteworthy...
  15. ncbi Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus
    Kazunari Ishii
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji, Japan
    Dement Geriatr Cogn Disord 25:329-35. 2008
    To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry.
  16. ncbi Endoscopic third ventriculostomy in idiopathic normal pressure hydrocephalus: an Italian multicenter study
    Michelangelo Gangemi
    Department of Neurological Sciences, Section of Neurosurgery, Federico II University School of Medicine, Naples, Italy
    Neurosurgery 63:62-7; discussion 67-9. 2008
    The aim of the report is to define the indications and results of endoscopic third ventriculostomy (ETV) in idiopathic normal pressure hydrocephalus and to discuss the physiopathological mechanism of this procedure.
  17. ncbi Expression of TGF-betas and TGF-beta type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus
    Xianfeng Li
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Neurosci Lett 413:141-4. 2007
    We investigated cerebrospinal fluid (CSF) samples from 21 patients with idiopathic normal pressure hydrocephalus (INPH) and 14 controls without neurological disease...
  18. ncbi Guidelines for management of idiopathic normal pressure hydrocephalus: progress to date
    A Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, VA 23219, USA
    Acta Neurochir Suppl 95:237-40. 2005
    ..this project was to develop evidenced based guidelines for the diagnosis and management of idiopathic normal pressure hydrocephalus (iNPH)...
  19. ncbi Striatal D2 receptor availability after shunting in idiopathic normal pressure hydrocephalus
    Teiji Nakayama
    Department of Neurosurgery, Hamamatsu Medical Center, Hamamatsu, Japan
    J Nucl Med 48:1981-6. 2007
    Gait disturbance in idiopathic normal pressure hydrocephalus (iNPH) is reminiscent of parkinsonism...
  20. ncbi Prevalence of probable idiopathic normal pressure hydrocephalus in a Norwegian population
    A Brean
    Department of Neurology, Vestfold County Hospital, Norway
    Acta Neurol Scand 118:48-53. 2008
    The clinical condition normal pressure hydrocephalus (NPH) is one of the few conditions with dementia that can be successfully treated...
  21. ncbi Meningeal derived cerebrospinal fluid proteins in different forms of dementia: is a meningopathy involved in normal pressure hydrocephalus?
    J Brettschneider
    Department of Neurology, University of Ulm, Germany
    J Neurol Neurosurg Psychiatry 75:1614-6. 2004
    ..Because dementia is associated with neuronal loss, we investigated whether leptomeningeal dysfunction may be involved in the pathogenesis of dementia disorders...
  22. ncbi Correlates of local cerebral blood flow (CBF) in normal pressure hydrocephalus patients before and after shunting--A retrospective analysis of [(15)O]H(2)O PET-CBF studies in 65 patients
    Petra M Klinge
    Department of Neurosurgery, International Neuroscience Institute, Rudolf Pichlmayr Str 4, 30625 Hannover, Germany
    Clin Neurol Neurosurg 110:369-75. 2008
    Findings in local cerebral blood flow (rCBF) in Normal pressure hydrocephalus (NPH) have always been challenged by the variable and inconsistent relation to clinical symptoms before and after shunt treatment...
  23. ncbi Measurement of peak CSF flow velocity at cerebral aqueduct, before and after lumbar CSF drainage, by use of phase-contrast MRI: utility in the management of idiopathic normal pressure hydrocephalus
    Ashwani Kumar Sharma
    Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India 110029
    Clin Neurol Neurosurg 110:363-8. 2008
    Since it was first described, normal pressure hydrocephalus (NPH) and its treatment by means of cerebrospinal fluid (CSF) shunting have been the focus of much investigation...
  24. ncbi Frequency analyses of CSF flow on cine MRI in normal pressure hydrocephalus
    Tosiaki Miyati
    Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80, Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Eur Radiol 13:1019-24. 2003
    ..Frequency analyses of CSF flow measured by cine MRI make it possible to noninvasively obtain a more detailed picture of the pathophysiology of NPH...
  25. ncbi Non-invasive measurement of intracranial compliance using cine MRI in normal pressure hydrocephalus
    M Mase
    Department of Neurosurgery and Restorative Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Acta Neurochir Suppl 95:303-6. 2005
    The aim of this study is to clarify biophysics of normal pressure hydrocephalus (NPH) based on non-invasive intracranial compliance measurement using magnetic resonance imaging (MRI)...
  26. ncbi Changes in aqueductal CSF stroke volume and progression of symptoms in patients with unshunted idiopathic normal pressure hydrocephalus
    A Scollato
    Department of Neurosurgery, Geriatric Agency, University of Florence, Florence, Italy
    AJNR Am J Neuroradiol 29:192-7. 2008
    Idiopathic normal pressure hydrocephalus (iNPH) represents a diagnostic challenge, given its variable presentation and progression...
  27. ncbi Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus
    Grant A Bateman
    Department of Medical Imaging, John Hunter Hospital, Newcastle Region Mail Centre, Locked Bag 1, Newcastle 2310, Australia
    Med Hypotheses 62:182-7. 2004
    The disorders of Alzheimer's disease, vascular dementia and normal pressure hydrocephalus are all causes of dementia in the elderly population. It is often the case that it is clinically very difficult to tell these diseases apart...
  28. ncbi Cognitive impairment in patients with idiopathic normal pressure hydrocephalus
    Atsushi Ogino
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Suita City, Japan
    Dement Geriatr Cogn Disord 21:113-9. 2006
    ..Recognition of these features contributes to an early diagnosis, which can lead to a better prognosis...
  29. ncbi Idiopathic normal pressure hydrocephalus may be a "two hit" disease: benign external hydrocephalus in infancy followed by deep white matter ischemia in late adulthood
    William G Bradley
    Department of Radiology, University of California, San Diego, San Diego, California 92103 8224, USA
    J Magn Reson Imaging 24:747-55. 2006
    To determine if normal pressure hydrocephalus (NPH) could result from decreased resorption of cerebrospinal fluid (CSF) by the arachnoidal villi, leading to benign external hydrocephalus [BEH] in infancy, followed by deep white matter ..
  30. ncbi Predictive assessment of shunt effectiveness in patients with idiopathic normal pressure hydrocephalus by determining regional cerebral blood flow on 3D stereotactic surface projections
    M Murakami
    Department of Neurosurgery, Kumamoto Takumadai Hospital, Kumamoto, Japan
    Acta Neurochir (Wien) 149:991-7. 2007
    The regional cerebral blood flow (rCBF) and cerebral metabolism in patients with idiopathic normal pressure hydrocephalus (iNPH) remain to be studied in detail.
  31. ncbi Evidence that congenital hydrocephalus is a precursor to idiopathic normal pressure hydrocephalus in only a subset of patients
    Robin K Wilson
    Adult Hydrocephalus Program, Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurol Neurosurg Psychiatry 78:508-11. 2007
    To identify the proportion of patients in a large idiopathic normal pressure hydrocephalus (INPH) cohort with large head circumference (HC) who presumably have congenital hydrocephalus that has not become clinically apparent until late ..
  32. ncbi Clinical guidelines for idiopathic normal pressure hydrocephalus
    Masatsune Ishikawa
    Department of Neurosurgery, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2 4 20 Oogi machi, Kita ku, Osaka 539 8480, Japan
    Neurol Med Chir (Tokyo) 44:222-3. 2004
    Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome characterized by gait disturbance, dementia, and/or urinary incontinence without causative disorders, and ventricular enlargement due to disturbance of the cerebrospinal fluid ..
  33. ncbi Is aqueductal stroke volume, measured with cine phase-contrast magnetic resonance imaging scans useful in predicting outcome of shunt surgery in suspected normal pressure hydrocephalus?
    Babar Kahlon
    Department of Neurosurgery, University Hospital, Lund, Sweden
    Neurosurgery 60:124-9; discussion 129-30. 2007
    ..clinical usefulness of cerebrospinal fluid stroke volume (SV) assessed in the cerebral aqueduct, via cine phase-contrast magnetic resonance imaging, for predicting outcome after shunt surgery in suspected normal pressure hydrocephalus.
  34. ncbi Lumbar infusion test in normal pressure hydrocephalus
    B Kahlon
    Department of Neurosurgery, University Hospital, Lund, Sweden
    Acta Neurol Scand 111:379-84. 2005
    ....
  35. ncbi Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus
    Tosiaki Miyati
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    J Magn Reson Imaging 26:274-8. 2007
    ..To assess the state and dynamics of the intracranial system in idiopathic normal-pressure hydrocephalus (I-NPH), we determined intracranial compliance using magnetic resonance imaging (MRI)...
  36. ncbi Five-year outcome of normal pressure hydrocephalus with or without a shunt: predictive value of the clinical signs, neuropsychological evaluation and infusion test
    S Savolainen
    Department of Neurosurgery, University Hospital, Kuopio, Finland
    Acta Neurochir (Wien) 144:515-23; discussion 523. 2002
    ..Between 1993-1995, 51 patients under 75 years of age with clinical symptoms and CT-based diagnosis of normal pressure hydrocephalus were investigated prospectively in order to clarify the value of neuropsychological tests, clinical ..
  37. ncbi Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly: a prospective study in a Japanese population
    Chifumi Iseki
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology DNHMED, Yamagata University School of Medicine, Yamagata, Japan
    J Neurol Sci 277:54-7. 2009
    We investigated if there are individuals at a preclinical stage of idiopathic normal pressure hydrocephalus (iNPH) in a general population...
  38. ncbi Normal pressure hydrocephalus or neuroborreliosis?
    Fahmy Aboul-Enein
    Department of Neurology, Sozialmedizinisches Zentrum Ost, Donauspital, Vienna, Austria
    Wien Med Wochenschr 159:58-61. 2009
    ..Clinical improvement after CSF spinal tap test suggested a normal pressure hydrocephalus syndrome...
  39. ncbi The importance of the intrathecal infusion test in the diagnosis of normal pressure hydrocephalus
    U Meier
    Department of Neurosurgery, Unfallkrankenhaus Berlin, Berlin, Germany
    J Clin Neurosci 9:260-7. 2002
    The intrathecal infusion test is a reliable method in diagnosing normal pressure hydrocephalus. Between May 1982 and January 2000 we investigated 300 patients suspected of having normal pressure hydrocephalus (NPH) by carrying out an ..
  40. ncbi Auditory event-related potentials differentiate patients with normal pressure hydrocephalus and patients with concomitant Alzheimer's disease verified by brain biopsy
    S Savolainen
    Department of Neurosurgery, University Hospital of Kuopio, Finland
    Neuroreport 12:33-7. 2001
    We studied 51 patients with clinical symptoms and CT findings suggesting normal pressure hydrocephalus (NPH)...
  41. ncbi Two-layer appearance on brain perfusion SPECT in idiopathic normal pressure hydrocephalus: a qualitative analysis by using easy Z-score imaging system, eZIS
    Seiju Kobayashi
    Department of Neuropsychiatry, Sapporo Medical University, Sapporo, Hokkaido, Japan
    Dement Geriatr Cogn Disord 28:330-7. 2009
    It is often difficult to distinguish idiopathic normal pressure hydrocephalus (iNPH) from other neurodegenerative disorders such as Alzheimer's disease (AD)...
  42. ncbi Is ventriculomegaly in idiopathic normal pressure hydrocephalus associated with a transmantle gradient in pulsatile intracranial pressure?
    Per Kristian Eide
    Department of Neurosurgery, Division of Clinical Neuroscience, Oslo University Hospital, Rikshospitalet HF, 0027 Oslo, Norway
    Acta Neurochir (Wien) 152:989-95. 2010
    In patients with idiopathic normal pressure hydrocephalus (iNPH) and ventriculomegaly, examine whether there is a gradient in pulsatile intracranial pressure (ICP) from within the cerebrospinal fluid (CSF) of cerebral ventricles (ICP(IV))..
  43. ncbi Agreement between CSF flow dynamics in MRI and ICP monitoring in the diagnosis of normal pressure hydrocephalus. Sensitivity and specificity of CSF dynamics to predict outcome
    M A Poca
    Department of Neurosurgery, Vall d'Hebron University Hospitals, Barcelona, Spain
    Acta Neurochir Suppl 81:7-10. 2002
    ..High CSF velocity through the aqueduct is a good predictor of improvement after surgery. However, patients with normal velocity in MR required additional tests before a diagnosis of NPH is ruled out...
  44. ncbi Cerebral hemodynamics before and after shunting in normal pressure hydrocephalus
    S L M Bakker
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    Acta Neurol Scand 106:123-7. 2002
    To study the relationship between cerebral hemodynamics and clinical performance in normal pressure hydrocephalus (NPH), before and after surgery.
  45. ncbi Clinical significance of cerebrospinal fluid tap test and magnetic resonance imaging/computed tomography findings of tight high convexity in patients with possible idiopathic normal pressure hydrocephalus
    Masatsune Ishikawa
    Department of Neurosurgery, Tazuke Kofukai Kitano Hospital, Osaka
    Neurol Med Chir (Tokyo) 50:119-23; disucussion 123. 2010
    Idiopathic normal pressure hydrocephalus (iNPH) is a treatable syndrome with a classical triad of symptoms...
  46. ncbi The role of cerebrospinal fluid flow study using phase contrast MR imaging in diagnosing idiopathic normal pressure hydrocephalus
    F T Al-Zain
    Department of Neurosurgery, Unfallkrankenhaus Berlin, Warener Strasse 7, 12683 Berlin, Germany
    Acta Neurochir Suppl 102:119-23. 2008
    ..prospective study was to identify the ability of cerebrospinal fluid flow study using phase contrast MR imaging to replace the invasive methods currently used to establish the diagnosis of idiopathic normal pressure hydrocephalus (iNPH).
  47. ncbi Techniques and complications of external lumbar drainage for normal pressure hydrocephalus
    Lance S Governale
    Department of Neurosurgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Neurosurgery 63:379-84; discussion 384. 2008
    To describe our system of external lumbar drainage for normal pressure hydrocephalus, detail its complications, and discuss changes made to that system with time.
  48. ncbi Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology
    Roy Hamilton
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Ann Neurol 68:535-40. 2010
    ..of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which ..
  49. ncbi Normal pressure hydrocephalus and cerebral blood flow: a review
    B K Owler
    Academic Neurosurgery Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurol Scand 104:325-42. 2001
    b>Normal pressure hydrocephalus is a neurological disease which poses both diagnostic and therapeutic problems for the clinician...
  50. ncbi The efficiency of PC-MRI in diagnosis of normal pressure hydrocephalus and prediction of shunt response
    Oktay Algin
    Department of Radiology, Uludag University Medical Faculty, Gorukle, Bursa, Turkey
    Acad Radiol 17:181-7. 2010
    In this prospective study, we aimed to reveal the efficiency of phase-contrast magnetic resonance imaging (PC-MRI) in the diagnosis of idiopathic normal pressure hydrocephalus (INPH) and prediction of shunt response.
  51. ncbi The role of computerized rheoencephalography in the assessment of normal pressure hydrocephalus
    W Traczewski
    Department of Neurotraumatology, Jagellonian University, Cracow, Poland
    J Neurotrauma 22:836-43. 2005
    ..amplitude pressure regression line (AMP/P) were calculated in 62 patients diagnosed with posttraumatic normal pressure hydrocephalus (NPH)...
  52. ncbi Failure of endoscopic third ventriculostomy in the treatment of idiopathic normal pressure hydrocephalus
    P L Longatti
    Neurosurgery Unit, Treviso Hospital, Treviso, Italy
    Minim Invasive Neurosurg 47:342-5. 2004
    Even though the main indication for neuroendoscopic management of normal pressure hydrocephalus (NPH) is the presence of an aqueductal block, recent reports suggest the possible efficacy of endoscopic third ventriculostomy (ETVS) in ..
  53. ncbi Comparative analysis of the gait disorder of normal pressure hydrocephalus and Parkinson's disease
    H Stolze
    Department of Neurology, Christian Albrechts Universitat zu Kiel, Niemannsweg 147, D 24105 Kiel, Germany
    J Neurol Neurosurg Psychiatry 70:289-97. 2001
    ..The aim of the present study was (1) to compare the gait disturbance in normal pressure hydrocephalus and Parkinson's disease; (2) to evaluate which variables of the disturbed gait pattern respond to ..
  54. ncbi CSF sulfatide distinguishes between normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy
    M Tullberg
    Institute of Clinical Neuroscience, Sahlgren s University Hospital, University of Goteborg, Sweden
    J Neurol Neurosurg Psychiatry 69:74-81. 2000
    ..neuronal function, and aminergic and peptidergic neurotransmission in a large series of patients with normal pressure hydrocephalus (NPH) or subcortical arteriosclerotic encephalopathy (SAE), to elucidate pathogenic, diagnostic, and ..
  55. ncbi BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstr 24, D 72076 Tuebingen, Germany
    J Psychiatr Res 41:387-94. 2007
    Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) are common forms of dementia in the elderly. Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD...
  56. ncbi Normal pressure hydrocephalus: a case report by a physician who is the patient
    Harold O Conn
    Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Med 7:296-9. 2007
    ..After ten years of progressive illness the correct diagnosis of normal pressure hydrocephalus (NPH) was finally made, revealing itself, by accident, through incontinence and mild dementia...
  57. ncbi Development of a quick reference table for setting programmable pressure valves in patients with idiopathic normal pressure hydrocephalus
    Hiroji Miyake
    Nishinomiya Kyoritsu Neurosurgical Hospital, Nishinomiya, Hyogo, Japan
    Neurol Med Chir (Tokyo) 48:427-32; discussion 432. 2008
    ..reliable setting of programmable pressure valves (PPVs) is important in the treatment of idiopathic normal pressure hydrocephalus (iNPH), especially for reducing overdrainage complications and related medical costs...
  58. ncbi Normal pressure hydrocephalus: long-term outcome after shunt surgery
    S Pujari
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Neurol Neurosurg Psychiatry 79:1282-6. 2008
    Little is known about the long-term clinical course and management of patients with normal pressure hydrocephalus (NPH) treated by cerebrospinal fluid (CSF) shunting.
  59. ncbi [Urinary dysfunction in idiopathic normal pressure hydrocephalus]
    Ryuji Sakakibara
    Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, Shimoshizu, Sakura, Chiba 285 8741, Japan
    Brain Nerve 60:233-9. 2008
    ..UI is well known as a clinical triad for the diagnosis of normal pressure hydrocephalus (NPH)...
  60. ncbi Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response
    J Golomb
    Silberstein Aging and Dementia Research Center, New York University, University School of Medicine, New York, NY 10016, USA
    J Neurol Neurosurg Psychiatry 68:778-81. 2000
    ..at biopsy was investigated in 56 cognitively impaired patients undergoing shunt surgery for idiopathic normal pressure hydrocephalus (NPH)...
  61. ncbi Normal pressure hydrocephalus: diagnosis and new approaches to treatment
    Ronan Factora
    Section of Geriatric Medicine, Department of General Internal Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Geriatr Med 22:645-57. 2006
    ..When they appear over time in the same patient, however, these symptoms raise the possibility of normal pressure hydrocephalus.
  62. ncbi Neuropsychological effects of shunt treatment in idiopathic normal pressure hydrocephalus
    Per Hellström
    Institute of Neuroscience and Physiology, Goteborg University, Gothenburg, Sweden
    Neurosurgery 63:527-35; discussion 535-6. 2008
    ..evaluate the effects of shunting on the neuropsychological performance of patients with idiopathic normal pressure hydrocephalus (INPH), to compare their performance with that of healthy individuals, and to estimate the predictive ..
  63. ncbi Normal pressure hydrocephalus (NPH): ischaemia, CSF stagnation or both
    Gerald D Silverberg
    Brain 127:947-8. 2004
  64. ncbi Is normal pressure hydrocephalus a valid concept in 2002? A reappraisal in five questions and proposal for a new designation of the syndrome as "chronic hydrocephalus"
    P Bret
    Service de Neurochirurgie B, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, 59 Boulevard Pinel, CHU de Lyon, 69394 Lyon Cedex 3, France
    J Neurol Neurosurg Psychiatry 73:9-12. 2002
    The authors question the current validity of the traditional concept of normal pressure hydrocephalus (NPH) as it was described by Adams and Hakim in 1965. The classic features of the disease are addressed...
  65. ncbi Clinical testing of CSF circulation
    Z Czosnyka
    Addenbrooke s Hospital, Academic Neurosurgery, Cambridge, UK
    Eur J Anaesthesiol Suppl 42:142-5. 2008
    ..Infusion studies, although invasive, may help with the decision about surgery. They also provide basic information for further management of shunted patients, when complications, such as shunt blockage, under- and over-drainage, arise...
  66. ncbi Functional and magnetic resonance imaging correlates of corpus callosum in normal pressure hydrocephalus before and after shunting
    María Mataró
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 78:395-8. 2007
    b>Normal pressure hydrocephalus (NPH) is associated with corpus callosum abnormalities.
  67. ncbi On the optimal opening pressure of hydrostatic valves in cases of idiopathic normal-pressure hydrocephalus: a prospective randomized study with 123 patients
    U Meier
    Department of Neurosurgery, Unfallkrankenhaus Berlin, Berlin, Germany
    Acta Neurochir Suppl 96:358-63. 2006
    ..Due to the prompt switching function when the patient changes posture (lying down, standing, sitting, slanting etc.), the Miethke gravity-assisted valve (GAV) is more suitable in such cases than the Miethke Dual-Switch valve (DSV)...
  68. ncbi Objective assessment of gait in normal-pressure hydrocephalus
    Michael A Williams
    Adult Hydrocephalus Program, Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Am J Phys Med Rehabil 87:39-45. 2008
    Gait abnormalities are an early clinical symptom in normal pressure hydrocephalus (NPH), and subjective improvement in gait after temporary removal of CSF is often used to decide to perform shunt surgery...
  69. ncbi Predicting the outcome of shunt surgery in normal pressure hydrocephalus
    K Kilic
    Department of Neurosurgery, Haydarpasa Numune Education and Research Hospital, Uskudar, Istanbul, Turkey
    J Clin Neurosci 14:729-36. 2007
    ..and prognostic value of periventricular hyperintensity (PVH) and of the classic clinical triad in normal pressure hydrocephalus. Two hundred and seventy patients were referred to the Departments of Neurosurgery, in Nancy, France ..
  70. ncbi Normal pressure hydrocephalus
    Diamanto Tsakanikas
    Department of Neurology and Neuroscience, New York Presbyterian Hospital Weill Cornell Medical Center, New York, New York 10021, USA
    Semin Neurol 27:58-65. 2007
    Idiopathic normal pressure hydrocephalus (INPH) is a treatable neurological disorder in older adults involving disturbances of gait/balance, control of micturition, and/or cognition in combination with enlargement of the cerebral ..
  71. ncbi Assessment of idiopathic normal pressure patients in neurological practice: the role of lumbar infusion testing for referral of patients to neurosurgery
    A Brean
    Department of Neurology, Vestfold Country Hospital, Oslo, Norway
    Eur J Neurol 15:605-12. 2008
    In neurological practice patients with tentative idiopathic normal pressure hydrocephalus (iNPH) usually are referred to neurosurgery based on clinical and radiological findings...
  72. ncbi When to consider normal pressure hydrocephalus in the patient with gait disturbance
    Ronan Factora
    Geriatrics 63:32-7. 2008
    b>Normal pressure hydrocephalus (NPH) is a chronic adult disorder of unknown cause. It is characterized by gradual onset of gait impairment, cognitive dysfunction, and urinary incontinence in the presence of enlarged ventricles...
  73. ncbi Cerebrospinal fluid dynamics: disturbances and diagnostics
    A Lavinio
    Addenbrooke s Hospital, Academic Neurosurgery, Cambridge, UK
    Eur J Anaesthesiol Suppl 42:137-41. 2008
    ..Infusion studies can assist in the prognostication of normal pressure hydrocephalus and in the diagnosis of idiopathic intracranial hypertension...
  74. ncbi Apparent diffusion coefficient and cerebrospinal fluid flow measurements in patients with hydrocephalus
    Yonca Anik
    Department of Radiology, School of Medicine, Kocaeli University, Umuttepe, Kocaeli, Turkey
    J Comput Assist Tomogr 32:392-6. 2008
    ..To evaluate the efficacy of diffusion magnetic resonance imaging and compare with cerebrospinal fluid (CSF) flow imaging in patients with hydrocephalus before and after treatment...
  75. ncbi [Idiopathic normal pressure hydrocephalus--overviews and pathogenesis]
    Masatsune Ishikawa
    Department of Neurosurgery, Kitano Hospital, Kita ku, Osaka 530 8480, Japan
    Brain Nerve 60:211-7. 2008
    Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome of gait disturbance, dementia and urinary incontinence without any preceding disorders in elderly patients...
  76. ncbi Normal pressure hydrocephalus: diagnosis and treatment
    David Shprecher
    University of Rochester School of Medicine, 1351 Mt Hope Avenue, Suite 100, Rochester, NY 14620, USA
    Curr Neurol Neurosci Rep 8:371-6. 2008
    b>Normal pressure hydrocephalus (NPH) is a syndrome of gait dysfunction and enlarged cerebral ventricles in the absence of another cause...
  77. ncbi Can MR measurement of intracranial hydrodynamics and compliance differentiate which patient with idiopathic normal pressure hydrocephalus will improve following shunt insertion?
    G A Bateman
    Department of Medical Imaging, John Hunter Hospital, Newcastle, Australia
    Acta Neurochir (Wien) 149:455-62; discussion 462. 2007
    Between 10 and 90% of patients with normal pressure hydrocephalus (NPH) treated with a shunt will improve but they risk significant morbidity/mortality from this procedure...
  78. ncbi Health economics and the search for shunt-responsive symptomatic hydrocephalus in the elderly
    John Douglas Pickard
    J Neurosurg 105:811-3; discussion 813-4. 2006
  79. ncbi Continuous intraventricular pressure monitoring for diagnosis of normal-pressure hydrocephalus
    W K Pfisterer
    Department of Neurosurgery, Donauspital SMZ Ost, Vienna, Austria
    Acta Neurochir (Wien) 149:983-90; discussion 990. 2007
    ..The aim of our study was to investigate whether long-term results after shunt implantation in NPH improve when surgical candidates are selected by continuous intraventricular pressure monitoring (CIPM)...
  80. ncbi Ventricular cerebrospinal fluid neurofilament protein levels decrease in parallel with white matter pathology after shunt surgery in normal pressure hydrocephalus
    M Tullberg
    Institute of Clinical Neuroscience, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Eur J Neurol 14:248-54. 2007
    b>Normal pressure hydrocephalus (NPH) is characterized by disturbed cerebrospinal fluid (CSF) dynamics and white matter lesions (WML). Although the morphology of these lesions is described, little is known about the biochemistry...
  81. ncbi Adaptive method for assessment of cerebrospinal fluid outflow conductance
    Nina Andersson
    Department of Biomedical Engineering and Informatics, Umea University Hospital, 901 85, Umea, Sweden
    Med Biol Eng Comput 45:337-43. 2007
    ..3 +/- 5.9 min (mean +/- SD), p<0.01. The reduction of reliability in the C(out) estimation was found clinically negligible. We thus recommend this adaptive method to be used when performing constant pressure infusion tests...
  82. ncbi The "reversible" dementia of idiopathic normal pressure hydrocephalus
    Caren McHenry Martin
    Consult Pharm 21:888-92, 901-3. 2006
    ..But, there also exists a small population of patients for whom these signs and symptoms are related to another-often curable-problem: idiopathic normal pressure hydrocephalus (iNPH).
  83. ncbi Features of gait most responsive to tap test in normal pressure hydrocephalus
    Lisa D Ravdin
    Department of Neurology and Neuroscience, New York Presbyterian Hospital, Weill Medical College of Cornell University, Cornell Memory Disorders Program, 428 East 72 Street, Suite 500, New York, NY 10021, United States
    Clin Neurol Neurosurg 110:455-61. 2008
    To identify components of gait associated with a positive tap test (TT) in patients with idiopathic normal pressure hydrocephalus (iNPH).
  84. ncbi Comparison between the lumbar infusion and CSF tap tests to predict outcome after shunt surgery in suspected normal pressure hydrocephalus
    B Kahlon
    Department of Neurosurgery, University Hospital, Lund, Sweden
    J Neurol Neurosurg Psychiatry 73:721-6. 2002
    ..fluid (CSF) tap test for predicting the outcome of shunt surgery in patients with suspected normal pressure hydrocephalus. METHODS: 68 patients with suspected normal pressure hydrocephalus were studied...
  85. ncbi Intracranial cerebrospinal fluid distribution and its postoperative changes in normal pressure hydrocephalus
    A Tsunoda
    Department of Neurosurgery, Koshigaya Municipal Hospital, Koshigaya City, Saitama, Japan
    Acta Neurochir (Wien) 143:493-9. 2001
    ..cerebrospinal fluid (CSF) volume measurement using MR-based methods in the management of patients with normal pressure hydrocephalus (NPH)...
  86. ncbi [Normal pressure hydrocephalus--from clinical picture to diagnosis. Help by early shunt placement]
    A Hischa
    Neurochirurgische Klinik,
    MMW Fortschr Med 143:78-80. 2001
    b>Normal pressure hydrocephalus (NPH), which may either be idiopathic or occur secondarily, is responsible for approximately 6% of the cases of dementional syndromes in the elderly...
  87. ncbi [Value of brain perfusion SPECT in the follow-up of patients surgically treated for chronic adult hydrocephalus syndrome]
    M J Díez Castro
    Servicio de Medicina Nuclear, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Rev Esp Med Nucl 22:287-94. 2003
    ..The aim of this study was to characterize regional cerebral blood flow in patients with Adult Hydrocephalus Syndrome (AHS) and to evaluate the changes in brain perfusion after surgical derivation treatment...
  88. ncbi Is the placement of shunts in patients with idiopathic normal-pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure
    Maria A Poca
    Department of Neurosurgery, Vall d Hebron University Hospital, Barcelona, Spain
    J Neurosurg 100:855-66. 2004
    ..A secondary aim was to determine the relationship between several clinical and neuroimaging factors, and patient outcome after surgery...
  89. ncbi [Incidence of surgery for hydrocephalus in adults surveyed: same number afflicted by hydrocephalus as by multiple sclerosis]
    M Hoglund
    Institutionen för klinisk neurovetenskap, Sahlgrenska Universitetssjukhuset, Goteborg
    Lakartidningen 98:1681-5. 2001
    ..3 to 6.3. The mean age was 60 years (range 18-92), with no sex difference. Normal pressure hydrocephalus (47%) was most common, followed by communicating high pressure hydrocephalus (27%) and aqueductal ..
  90. ncbi Decreases in ventricular volume correlate with decreases in ventricular pressure in idiopathic normal pressure hydrocephalus patients who experienced clinical improvement after implantation with adjustable valve shunts
    Kathleen A McConnell
    Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 55:582-92; discussion 592-3. 2004
    ..in adjustable valve pressure settings in a cohort of patients who received shunts to treat idiopathic normal pressure hydrocephalus. We also examined whether these pressure-volume curves and other patient variables would co-occur with ..
  91. ncbi [Optimal use of the lumbar infusion test in patients with communicating hydrocephalus. Theoretical considerations in comparison to clinical observations]
    Krzysztof Cieslicki
    Pracownia Mechaniki Płynow, Instytut Automatyki i Robotyki, Politechnika Warszawska, ul Sw Andrzeja Boboli 8, 02 525 Warszawa
    Neurol Neurochir Pol 38:189-95. 2004
    ..The aim of this paper is to assess the possibility of reducing the duration of IT. The study was based on a theoretical model and the analysis of selected IT performed in patients suffering from normal pressure hydrocephalus.
  92. ncbi The grading of normal pressure hydrocephalus
    U Meier
    Department of Neurosurgery, Unfallkrankenhaus Berlin
    Biomed Tech (Berl) 47:54-8. 2002
    PATIENTS AND METHOD: During a period of 15 years we investigated 200 patients suspected of normal pressure hydrocephalus (NPH) by means of an intrathecal infusion test...
  93. ncbi Calculation of the resistance to CSF outflow
    M Czosnyka
    J Neurol Neurosurg Psychiatry 74:1354; author reply 1354-5. 2003
  94. ncbi Cerebral haemodynamics in patients with hydrocephalus after subarachnoid haemorrhage due to ruptured aneurysm
    Chia Cheng Chang
    Department of Neurosurgery, Yokohama Minami Kyosai Hospital, 1 21 1 Mutsuurahigashi, Kanazawa Ku, Yokohama, Japan 236 0037
    Eur J Nucl Med Mol Imaging 30:123-6. 2003
    Cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) may be reduced in patients with normal pressure hydrocephalus (NPH) after subarachnoid haemorrhage (SAH)...
  95. ncbi How to select patients with normal pressure hydrocephalus for shunting
    J Th J Tans
    Department of Neurology, Westeinde Hospital, The Hague, The Netherlands
    Acta Neurochir Suppl 81:3-5. 2002
    ..8-17.9). We conclude that CVD is an important predictor of poor outcome. The best strategy is to shunt NPH patients if Rcsf is > 18 mmHg/ml/min or, when Rcsf is lower, if CT findings are typical for NPH and there is no or limited CVD...
  96. ncbi [Shunt operation versus endoscopic ventriculostomy in normal pressure hydrocephalus: diagnostics and outcome]
    U Meier
    Klinik für Neurochirurgie, Unfallkrankenhaus Berlin
    Zentralbl Neurochir 64:19-23. 2003
    ..contrast to shunt operation the indication for an endoscopic ventriculostomy in patients diagnosed for normal pressure hydrocephalus is not scientifically established...
  97. ncbi The reversibility of reduced cortical vein compliance in normal-pressure hydrocephalus following shunt insertion
    G A Bateman
    Department of Medical Imaging, John Hunter Hospital, Locked Bag 1, Newcastle Region Mail Centre, 2310 Australia
    Neuroradiology 45:65-70. 2003
    ..compression secondary to alterations in craniospinal compliance is implicated in the pathogenesis of normal pressure hydrocephalus (NPH)...
  98. ncbi Is a combination of Tc-SPECT or perfusion weighted magnetic resonance imaging with spinal tap test helpful in the diagnosis of normal pressure hydrocephalus?
    F Hertel
    Department of Neurosurgery, Bruderkrankenhaus Trier, University of Trier, Nordallee 1, D 54292 Trier, Germany
    J Neurol Neurosurg Psychiatry 74:479-84. 2003
    ..assessed either by Tc-bicisate-SPECT (Tc-SPECT) or perfusion weighted MRI (pwMRI), or both, for a better preoperative selection of promising candidates for shunt operations in suspected idiopathic normal pressure hydrocephalus.
  99. ncbi [Outcome predictors in patients with normal pressure hydrocephalus]
    U Meier
    Klinik für Neurochirurgie, Unfallkrankenhaus Berlin
    Biomed Tech (Berl) 48:74-81. 2003
    ..of knowledge over the years, the postoperative results of shunt implantation in patients with normal pressure hydrocephalus (NPH) have shown little improvement...
  100. ncbi Predicting the outcome of shunt surgery in normal pressure hydrocephalus
    V G Ramesh
    J Clin Neurosci 15:1067; author reply 1067-8. 2008
  101. ncbi Normal pressure hydrocephalus triggers intrathecal production of TNF-alpha
    E Tarkowski
    Department of Rheumatology and Neurology, University of Goteborg, Guldhedsgatan 10, S 413 46, Goteborg, Sweden
    Neurobiol Aging 24:707-14. 2003
    b>Normal pressure hydrocephalus (NPH) is associated with periventricular white matter lesions and demyelination...

Research Grants67

  1. Cognitive Recovery in Normal Pressure Hydrocephalus
    Heather Katzen; Fiscal Year: 2007
    b>Normal Pressure Hydrocephalus (NPH) is an age-related disorder contributing to an estimated 1-6% of all dementia in the elderly...
  2. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  3. Data Mining Based Noninvasive Intracranial Pressure Assessment
    Xiao Hu; Fiscal Year: 2007
    ..of DM NICP with two distinct patient population databases: traumatic brain injury (TBI) and normal pressure hydrocephalus (NPH)...
  4. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    Anthony Marmarou; Fiscal Year: 2007
    ..Taken in concert, these studies will provide a more indepth understanding of the role of aquaporins in brain injury and introduce novel therapeutic approaches for treating brain edema. ..
  5. "Naturalistic Assessment of the Driving ability of Cognitively Impaired Elders
    Brian Ott; Fiscal Year: 2007
    ....
  6. A LONGITUDINAL STUDY OF HAZARDOUS DRIVERS WITH DEMENTIA
    Brian Ott; Fiscal Year: 2004
    ..abstract_text> ..
  7. Neural Basis of Unilateral Spatial Neglect
    Argye Hillis; Fiscal Year: 2007
    ..Results are expected to reveal distinct areas of cortex crucial for computing spatial representations with different reference frames, and to reveal mechanisms of USN in tasks with different purposes. ..
  8. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
    ..The results may have important public health implications in that improved understanding of the pathological consequences of cerebral amyloid deposition may lead to medical treatments that will improve outcome following TBI. ..
  9. 1H MRS markers of MCI syndromes and common dementias
    Kejal Kantarci; Fiscal Year: 2007
    ....
  10. Neural bases of empathy and prosody
    Argye E Hillis; Fiscal Year: 2010
    ..The results will also have clinical impact by aiding in functional prognosis in acute stroke, and in identifying appropriate candidates for intervention to restore blood flow in patients with such deficits due to acute stroke. ..
  11. Neural bases of language and cognitive deficits in acute stroke and recovery
    Argye E Hillis; Fiscal Year: 2010
    ..The results will also have clinical impact by aiding in functional prognosis in acute stroke and in identifying appropriate candidates for intervention to restore blood flow in patients with language deficits due to acute stroke. ..
  12. Naturalistic Assessment of the Driving ability of Cognitively Impaired Elders
    BRIAN RICHARD OTT; Fiscal Year: 2010
    ....
  13. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  14. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2010
    The management of normal pressure hydrocephalus (NPH) is challenging due to diagnostic uncertainties and high treatment risks. To date, there are no evidence-based treatment guidelines for this disorder...
  15. DEVELOPMENT OF CHOROID PLEXUS-TRANSPORT SYSTEMS
    Conrad Johanson; Fiscal Year: 1993
    ..Therapeutic implications: Functional information about the CP-CSF system should enhance understanding of pathophysiology of fluid disorders like hydrocephalus, edema, etc...
  16. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2009
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  17. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2007
    The management of normal pressure hydrocephalus (NPH) is challenging due to diagnostic uncertainties and high treatment risks. To date, there are no evidence-based treatment guidelines for this disorder...
  18. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2007
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  19. Neural Basis of Lexical Deficits in Hyperacute Stroke
    Argye Hillis; Fiscal Year: 2006
    ..It is also hypothesized that repeat DWI, PWI, and language tests at 3 days post-onset will reveal mechanisms of early recovery of lexical functions in acute stroke. ..
  20. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Our long-term goal is to delineate the multifunctional roles of CP in brain fluid homeostasis. ..
  21. Neural bases of language and cognitive deficits in acute stroke and recovery
    Argye Hillis; Fiscal Year: 2007
    ..The results will also have clinical impact by aiding in functional prognosis in acute stroke and in identifying appropriate candidates for intervention to restore blood flow in patients with language deficits due to acute stroke. ..
  22. A HEMODYNAMIC MODEL OF INTRACRANIAL PRESSURE DYNAMICS
    Marvin Bergsneider; Fiscal Year: 2002
    ..An improved understanding of these disorders will offer new and better treatment modalities for millions of affected patients. ..