hydrocephalus

Summary

Summary: Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA (and in infants macrocephaly). This condition may be caused by obstruction of cerebrospinal fluid pathways due to neurologic abnormalities, INTRACRANIAL HEMORRHAGES; CENTRAL NERVOUS SYSTEM INFECTIONS; BRAIN NEOPLASMS; CRANIOCEREBRAL TRAUMA; and other conditions. Impaired resorption of cerebrospinal fluid from the arachnoid villi results in a communicating form of hydrocephalus. Hydrocephalus ex-vacuo refers to ventricular dilation that occurs as a result of brain substance loss from CEREBRAL INFARCTION and other conditions.

Top Publications

  1. ncbi A contemporary definition and classification of hydrocephalus
    Harold L Rekate
    Department of Pediatric Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 16:9-15. 2009
  2. ncbi Relationship between cerebrospinal fluid and blood dynamics in healthy volunteers and patients with communicating hydrocephalus
    Olivier Baledent
    Department of Imaging and Biophysics, UMR 6600 CNRS, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France
    Invest Radiol 39:45-55. 2004
  3. ncbi Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes
    Elizabeth J Sweger
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:2309-17. 2007
  4. ncbi Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
    Nat Neurosci 13:700-7. 2010
  5. ncbi [Benign idiopathic external hydrocephalus (benign subdural collection) in 39 children: its natural history and relation to familial macrocephaly]
    M Castro-Gago
    Departamento de Pediatria, Hospital Clinico Universitario de Santiago de Compostela, La Choupana s n, E 15706 Santiago de Compostela, Spain
    Rev Neurol 40:513-7. 2005
  6. ncbi Genetic disorders associated with macrocephaly
    Charles A Williams
    Raymond C Philips Research and Education Unit, Division of Genetics, Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    Am J Med Genet A 146:2023-37. 2008
  7. ncbi Vision in children with hydrocephalus
    Susann Andersson
    Department of Ophthalmology, Institute of Clinical Neuroscience, The Sahlgrenska Academy of Göteborg University, Goteborg, Sweden
    Dev Med Child Neurol 48:836-41. 2006
  8. ncbi Routine measurement of head circumference as a tool for detecting intracranial expansion in infants: what is the gain? A nationwide survey
    Sverre Morten Zahl
    Department of Surgery, Voss Hospital, Voss, Norway
    Pediatrics 121:e416-20. 2008
  9. ncbi Clinical and neuroradiological predictors of mortality in patients with primary pontine hemorrhage
    Kemal Balci
    Department of Neurology, School of Medicine, Trakya University, Edirne, Turkey
    Clin Neurol Neurosurg 108:36-9. 2005
  10. ncbi Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations
    E Parrini
    Research Institute, I.R.C.C.S, Stella Maris Foundation, University of Pisa, Italy
    Brain 129:1892-906. 2006

Research Grants

  1. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
  2. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2009
  3. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    KATHLEEN SWEADNER; Fiscal Year: 2009
  4. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2007
  5. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
  6. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2009
  7. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
  8. Conferene on the basic cell and molecular biology of cilia and flagella as relate
    Joel Rosenbaum; Fiscal Year: 2007
  9. FETAL MAGNETOENCEPHALOGRAPHY AND EVOKED POTENTIALS
    Curtis Lowery; Fiscal Year: 2000
  10. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2007

Detail Information

Publications329 found, 100 shown here

  1. ncbi A contemporary definition and classification of hydrocephalus
    Harold L Rekate
    Department of Pediatric Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 16:9-15. 2009
    This review focuses on the problems related to defining hydrocephalus and on the development of a consensus on the classification of this common problem...
  2. ncbi Relationship between cerebrospinal fluid and blood dynamics in healthy volunteers and patients with communicating hydrocephalus
    Olivier Baledent
    Department of Imaging and Biophysics, UMR 6600 CNRS, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France
    Invest Radiol 39:45-55. 2004
    ..MRI), we investigated cerebral blood and cerebrospinal fluid (CSF) flows in patients with communicating hydrocephalus (CH) and in healthy volunteers to determine the contribution of CSF flow to brain pressure regulation in CH ..
  3. ncbi Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes
    Elizabeth J Sweger
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:2309-17. 2007
    ..Surprisingly, we found that all transgenics expressing Ro1 developed hydrocephalus. We analyzed these mice in an effort to develop a new model of hydrocephalus that will further our ..
  4. ncbi Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
    Nat Neurosci 13:700-7. 2010
    ..development and planar organization of ependymal cilia are compromised, leading to defective CSF dynamics and hydrocephalus. In Celsr2 and Celsr3 double mutant ependyma, ciliogenesis is markedly impaired, resulting in lethal ..
  5. ncbi [Benign idiopathic external hydrocephalus (benign subdural collection) in 39 children: its natural history and relation to familial macrocephaly]
    M Castro-Gago
    Departamento de Pediatria, Hospital Clinico Universitario de Santiago de Compostela, La Choupana s n, E 15706 Santiago de Compostela, Spain
    Rev Neurol 40:513-7. 2005
    Benign idiopathic external hydrocephalus (BIEH) is an age-dependent disorder that is self-limiting in time and has an uncertain aetiology.
  6. ncbi Genetic disorders associated with macrocephaly
    Charles A Williams
    Raymond C Philips Research and Education Unit, Division of Genetics, Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    Am J Med Genet A 146:2023-37. 2008
    ..Some emphasis is placed on familial macrocephaly (sometimes referred to as benign external hydrocephalus) and on the macrocephaly associated with autism spectrum disorders...
  7. ncbi Vision in children with hydrocephalus
    Susann Andersson
    Department of Ophthalmology, Institute of Clinical Neuroscience, The Sahlgrenska Academy of Göteborg University, Goteborg, Sweden
    Dev Med Child Neurol 48:836-41. 2006
    b>Hydrocephalus in children has many aetiologies, and can cause multiple ophthalmic and visual disorders...
  8. ncbi Routine measurement of head circumference as a tool for detecting intracranial expansion in infants: what is the gain? A nationwide survey
    Sverre Morten Zahl
    Department of Surgery, Voss Hospital, Voss, Norway
    Pediatrics 121:e416-20. 2008
    ..The aim of the present study was to investigate the importance of routine head circumference measurements in the detection of intracranial expansive conditions, because only fragmented evidence exists in favor of this routine...
  9. ncbi Clinical and neuroradiological predictors of mortality in patients with primary pontine hemorrhage
    Kemal Balci
    Department of Neurology, School of Medicine, Trakya University, Edirne, Turkey
    Clin Neurol Neurosurg 108:36-9. 2005
    ..of hemorrhage, intraventricular and extrapontine extension, necessity of mechanical ventilation and hydrocephalus. The hematoma volumes were measured with the formulation described by Broderick...
  10. ncbi Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations
    E Parrini
    Research Institute, I.R.C.C.S, Stella Maris Foundation, University of Pisa, Italy
    Brain 129:1892-906. 2006
    ..and cerebellar hypoplasia, PNH with fronto-perisylvian or temporo-occipital polymicrogyria, posterior PNH with hydrocephalus, PNH with microcephaly, PNH with frontonasal dysplasia, PNH with limb abnormalities, PNH with fragile-X ..
  11. ncbi Evidence that congenital hydrocephalus is a precursor to idiopathic normal pressure hydrocephalus in only a subset of patients
    Robin K Wilson
    Adult Hydrocephalus Program, Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurol Neurosurg Psychiatry 78:508-11. 2007
    To identify the proportion of patients in a large idiopathic normal pressure hydrocephalus (INPH) cohort with large head circumference (HC) who presumably have congenital hydrocephalus that has not become clinically apparent until late ..
  12. ncbi Shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage: incidence, predictors, and revision rates. Clinical article
    Cian J O'Kelly
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    J Neurosurg 111:1029-35. 2009
    Chronic shunt-dependent hydrocephalus is a recognized complication of aneurysmal subarachnoid hemorrhage...
  13. ncbi Macrocephaly, increased intracranial pressure, and hydrocephalus in the infant and young child
    Alexandra T Vertinsky
    Stanford University Medical Center, Stanford, CA, USA
    Top Magn Reson Imaging 18:31-51. 2007
    Macrocephaly, increased intracranial pressure, and hydrocephalus are common related conditions that lead to cross-sectional imaging of the infant and young child...
  14. ncbi Hydrocephalus in children born in 1999-2002: epidemiology, outcome and ophthalmological findings
    Eva Karin Persson
    Department of Paediatrics, Halmstad County Hospital, Halmstad, Sweden
    Childs Nerv Syst 23:1111-8. 2007
    The purpose of this study was to monitor incidence and outcome in children with hydrocephalus.
  15. ncbi Alterations of pulsation absorber characteristics in experimental hydrocephalus
    Eun Hyoung Park
    Department of Neurosurgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosurg Pediatr 6:159-70. 2010
    ..absorbance respond to changes in CSF movement under obstructive conditions such as the development of hydrocephalus? In the present study, chronic obstructive hydrocephalus was induced by the injection of cyanoacrylate gel ..
  16. ncbi Cerebrovascular adaptation in chronic hydrocephalus
    M G Luciano
    Section of Pediatric and Congenital Neurosurgery, Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44118, USA
    J Cereb Blood Flow Metab 21:285-94. 2001
    This study characterizes the regional changes in vascularity, which accompanies chronic progressive hydrocephalus. Fifteen dogs underwent surgical induction of hydrocephalus and were used for histologic studies...
  17. ncbi CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1
    E Fransen
    Department of Medical Genetics, University of Antwerp, Belgium
    Eur J Hum Genet 3:273-84. 1995
    ..We review here the evidence that several X-linked mental retardation syndromes including X-linked hydrocephalus (HSAS), MASA syndrome, X-linked complicated spastic paraparesis (SP1) and X-linked corpus callosum agenesis (..
  18. ncbi Who will care for me next? Transitioning to adulthood with hydrocephalus
    Tamara D Simon
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84113, USA
    Pediatrics 124:1431-7. 2009
    b>Hydrocephalus is a prototypical chronic condition that follows children into adulthood...
  19. ncbi Management of hydrocephalus in patients with tuberculous meningitis
    Vedantam Rajshekhar
    Department of Neurological Sciences, Christian Medical College, Vellore, India
    Neurol India 57:368-74. 2009
    b>Hydrocephalus is one of the commonest complications of tuberculous meningitis (TBM) occurring in up to 85% of children with the disease. It is more severe in children than in adults...
  20. ncbi VEGF/VEGFR-2 changes in frontal cortex, choroid plexus, and CSF after chronic obstructive hydrocephalus
    Jun Yang
    Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, Cleveland Clinic, S 60, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Neurol Sci 296:39-46. 2010
    Chronic hydrocephalus (CH) is often associated with decreased cerebral blood flow (CBF) and oxygen levels...
  21. ncbi Factors related to hydrocephalus after aneurysmal subarachnoid hemorrhage
    Zeena Dorai
    Department of Neurosurgery, University of Texas at Southwestern Medical Center, Dallas 75390 8855, USA
    Neurosurgery 52:763-9; discussion 769-71. 2003
    The purpose of this study was to identify factors predictive of shunt-dependent hydrocephalus among patients with aneurysmal subarachnoid hemorrhage...
  22. ncbi Value of phase contrast magnetic resonance imaging for investigation of cerebral hydrodynamics
    O Baledent
    Department of Nuclear Medicine and Imaging, CHU Nord, Place Victor Pauchet, Amiens Cedex, France
    J Neuroradiol 33:292-303. 2006
    ..The objective of this paper is to describe the contribution of this technique in diseases related to disorders of cerebral hydrodynamics in the light of 5 clinical cases...
  23. ncbi Radiological assessment of hydrocephalus: new theories and implications for therapy
    Dan Greitz
    Department of Neuroradiology and MR Research Center, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Neurosurg Rev 27:145-65; discussion 166-7. 2004
    It is almost a century since Dandy made the first experimental studies on hydrocephalus, but its underlying mechanism has been unknown up to now...
  24. ncbi Differences in cerebrospinal fluid dynamics do not affect the levels of biochemical markers in ventricular CSF from patients with aqueductal stenosis and idiopathic normal pressure hydrocephalus
    M Tisell
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Eur J Neurol 11:17-23. 2004
    ..cerebrospinal fluid (vCSF) between patients with aqueductal stenosis (AS) and idiopathic normal pressure hydrocephalus (INPH) and relate these results to clinical outcome after surgery...
  25. ncbi "Benign" extra-axial fluid in survivors of neonatal intensive care
    Scott A Lorch
    Center for Outcomes Research, Department of Neonatology, The Children s Hospital of Philadelphia, 3535 Market Street, Suite 1029, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 158:178-82. 2004
    ..To identify the prevalence of "benign" extra-axial fluid (BEAF), the risk factors associated with this condition, and the natural history in "graduates" of neonatal intensive care...
  26. ncbi The stumpy gene is required for mammalian ciliogenesis
    Terrence Town
    Department of Immunobiology and Neurobiology, Section of Nephrology, Yale University School of Medicine, 300 Cedar Street, TAC S 569, New Haven, CT 06519 8011, USA
    Proc Natl Acad Sci U S A 105:2853-8. 2008
    ..Stumpy was ubiquitously expressed, and conditional loss in mouse resulted in complete penetrance of perinatal hydrocephalus (HC) and severe polycystic kidney disease (PKD)...
  27. ncbi The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice
    Hee Kyung Hong
    Howard Hughes Medical Institute, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 101:1748-53. 2004
    ..The hyh mutant provides a valuable in vivo model to study vesicle/membrane trafficking and provides insight into the potential roles of alpha-SNAP in embryogenesis and brain development...
  28. ncbi Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus
    M E Wagshul
    Department of Radiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794 8460, USA
    Exp Neurol 218:33-40. 2009
    In communicating hydrocephalus (CH), explanations for the symptoms and clear-cut effective treatments remain elusive...
  29. ncbi Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus
    Gerald D Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA
    J Neurosurg 97:1271-5. 2002
    The goal of this study was to determine the effect of hydrocephalus on cerebrospinal fluid (CSF) production rates in patients with acute and chronic hydrocephalus.
  30. ncbi Alterations in brain metabolism, CNS morphology and CSF dynamics in adult rats with kaolin-induced hydrocephalus
    Daniel Kondziella
    Department of Clinical Neuroscience, Faculty of Medicine, Olav Kyrresgt. 3, N-7489 Trondheim, Norway
    Brain Res 927:35-41. 2002
    ..the biochemical changes, morphological development and the cerebrospinal fluid dynamics of the kaolin-induced hydrocephalus in the adult rat...
  31. ncbi Posttraumatic hydrocephalus: a clinical, neuroradiologic, and neuropsychologic assessment of long-term outcome
    Letizia Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Turin, Italy
    Arch Phys Med Rehabil 84:1637-41. 2003
    To detect the clinical and radiologic characteristics of posttraumatic hydrocephalus (PTH), to define its prognostic value, and to assess the effects of shunt surgery.
  32. ncbi Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages
    Paula Dietrich
    Department of Physiology, The University of Tennessee, Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 18:142-50. 2009
    ..Here we show that conditional inactivation of the Hdh gene in Wnt1 cell lineages results in congenital hydrocephalus, implicating huntingtin for the first time in the regulation of cerebral spinal fluid (CSF) homeostasis...
  33. ncbi The expression of inherited hydrocephalus in H-Tx rats
    H C Jones
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville 32610, USA
    Childs Nerv Syst 16:578-84. 2000
    OBJECTIVES: H-Tx rats develop severe hydrocephalus in late gestation. The breeding colony maintained at the University of Florida stems from one pair obtained in 1992...
  34. ncbi Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain
    A N Tullio
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Comp Neurol 433:62-74. 2001
    Ablation of nonmuscle myosin heavy chain II-B (NMHC-B) in mice results in severe hydrocephalus with enlargement of the lateral and third ventricles. All B(-)/B(-) mice died either during embryonic development or on the day of birth (PO)...
  35. ncbi Visual field constriction in children with shunt-treated hydrocephalus
    Diana Rudolph
    Department of Pediatric Surgery, University of Leipzig, Germany
    J Neurosurg Pediatr 6:481-5. 2010
    Many ophthalmological abnormalities are described in conjunction with hydrocephalus. The results of visual field diagnosis remain a matter of further discussion...
  36. ncbi Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages
    Mitsunari Nakajima
    Department of Pharmaceutical Pharmacology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, 4 2 Bunkyo cho, Matsuyama 790 8578, Ehime, Japan
    Brain Res 1382:275-81. 2011
    ..Here we show that conditional inactivation of PS1 in Wnt1 cell lineages results in congenital hydrocephalus and subcommissural organ abnormalities, suggesting a possible role of PS1 in the regulation of cerebrospinal ..
  37. ncbi Management of hydrocephalus associated with occipital encephalocoele using endoscopic third ventriculostomy: report of two cases
    Ranjith K Moorthy
    Department of Neurological Sciences, Christian Medical College Hospital, Vellore, India
    Surg Neurol 57:351-5; discussion 355. 2002
    ..encephalocoele is the most common cranial dysraphism in the western hemisphere and is often complicated by hydrocephalus. Management of hydrocephalus and reducing the CSF pressure is crucial in preventing dehiscence at the site of ..
  38. ncbi Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus
    E Galbreath
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, USA
    J Neuropathol Exp Neurol 54:339-49. 1995
    ..Surprisingly, these mice developed severe hydrocephalus and died between birth and 3 weeks of age...
  39. ncbi Management of hydrocephalus in infants by using shunts with adjustable valves
    Martin R Weinzierl
    Department of Neurosurgery, University Hospital RWTH, Aachen, Germany
    J Neurosurg Pediatr 2:14-8. 2008
    ..The goal of this prospective study was to assess the efficacy of valve adjustments in preventing slitlike ventricles in children < 6 months old after the first shunt insertion...
  40. ncbi Extent of acute hydrocephalus after aneurysmal subarachnoid hemorrhage as a risk factor for delayed cerebral infarction
    Annelies M Bakker
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 38:2496-9. 2007
    ..Cerebral perfusion is a predictor for DCI. Because acute hydrocephalus may impair cerebral perfusion, we evaluated the predictive value of the extent of acute hydrocephalus on the ..
  41. ncbi Multilevel primary intraspinal PNETs in an infant associated with hydrocephalus
    Doga Gurkanlar
    Baskent University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey
    Turk Neurosurg 20:82-5. 2010
    ..we present a 40-day-old infant with multilevel primary spinal PNET at Th12-L1 and L5-S1 levels associated with hydrocephalus occurring nearly 15 days after the operation...
  42. ncbi A multicenter prospective cohort study of the Strata valve for the management of hydrocephalus in pediatric patients
    John R W Kestle
    Division of Pediatric Neurosurgery, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    J Neurosurg 102:141-5. 2005
    ..To evaluate these claims, the authors conducted a prospective multicenter cohort study of children who underwent placement of Strata valves...
  43. ncbi Long-term outcome in 109 adult patients operated on for hydrocephalus
    M Tisell
    Hydrocephalus Research Unit, Institute of Clinical Neuroscience, Sahlgrenska Academy at Goteborg University, Sweden
    Br J Neurosurg 20:214-21. 2006
    To examine the long-term effects of surgery in adult hydrocephalus we conducted a cross-sectional questionnaire study assessing both the patients' sense of well-being, and changes in gait, living conditions, daily need of sleep and ..
  44. ncbi The importance of the cortical subarachnoid space in understanding hydrocephalus
    Harold L Rekate
    Pediatric Neurosciences, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Neurosurg Pediatr 2:1-11. 2008
    ..this paper the authors define the role of the cortical subarachnoid space (CSAS) in poorly understood forms of hydrocephalus to cerebrospinal fluid (CSF) dynamics to improve understanding of the importance of the CSAS and its role in ..
  45. ncbi Neuropathology and structural changes in hydrocephalus
    Marc R Del Bigio
    Department of Pathology, University of Manitoba, and Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada
    Dev Disabil Res Rev 16:16-22. 2010
    In the context of spina bifida, hydrocephalus is usually caused by crowding of the posterior fossa with obstruction to cerebrospinal fluid flow from the forth ventricle, and less often by malformation of the cerebral aqueduct...
  46. ncbi Intracranial pressure monitoring with the Neurodur-P epidural sensor: a prospective study in patients with adult hydrocephalus or idiopathic intracranial hypertension
    Maria A Poca
    Department of Neurosurgery, Vall d Hebron University Hospital, Institut de Recerca Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    J Neurosurg 108:934-42. 2008
    ..The aim of this study was to assess the safety and accuracy of the Neurodur-P epidural sensor in the clinical setting...
  47. ncbi External hydrocephalus in small children
    Raj Kumar
    Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, UP, India
    Childs Nerv Syst 22:1237-41. 2006
    Confusion exists in literature regarding the entity of external hydrocephalus which has been addressed by different terms like subdural effusion, hygroma, benign infantile hydrocephalus, etc...
  48. ncbi Gray matter metabolism in acute and chronic hydrocephalus
    D Kondziella
    Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
    Neuroscience 159:570-7. 2009
    Although hydrocephalus is usually considered a disorder of periventricular white matter, disturbance of gray matter is probably also involved...
  49. ncbi Endoscopic third ventriculostomy in obstructed hydrocephalus
    D Singh
    Department of Neurosurgery, G.B. Pant Hospital, Delhi, India
    Neurol India 51:39-42. 2003
    Forty-three ETV were performed in 46 patients of obstructive hydrocephalus. Study was divided into two groups. Group 1 was with 29 children of less than two years age...
  50. ncbi Stereotactic radiosurgery and vestibular schwannoma: hydrocephalus associated with the development of a secondary arachnoid cyst: a report of two cases and review of the literature
    C Hayhurst
    Department of Neurosurgery, University Hospital of North Staffordshire, Royal Infirmary, Stoke on Trent, UK
    Br J Neurosurg 19:178-81. 2005
    ..In one case this was associated with progressive ventriculomegaly and the onset of symptomatic hydrocephalus requiring emergency treatment...
  51. ncbi Shunt surgery effects on cerebrospinal fluid flow across the aqueduct of Sylvius in patients with communicating hydrocephalus
    Pooja Abbey
    Radiology, All India Institute of Medical Sciences, New Delhi, India
    J Clin Neurosci 16:514-8. 2009
    ..quantify the flow of cerebrospinal fluid (CSF) across the aqueduct of Sylvius in patients with communicating hydrocephalus using phase contrast MRI, and to evaluate the effect of ventriculoperitoneal (VP) shunt surgery on flow...
  52. ncbi The role of endoscopic third ventriculostomy in adult patients with hydrocephalus
    Michael D Jenkinson
    Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Liverpool, L9 7LJ, United Kingdom
    J Neurosurg 110:861-6. 2009
    Endoscopic third ventriculostomy (ETV) is the treatment of choice for hydrocephalus, but the outcome is dependent on the cause of this disorder, and the procedure remains principally the preserve of pediatric neurosurgeons...
  53. ncbi Perioperative risk factors for short term shunt revisions in adult hydrocephalus patients
    D Farahmand
    Hydrocephalus Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Neurol Neurosurg Psychiatry 80:1248-53. 2009
    The aim of this study was to prospectively study perioperative variables associated with revision after shunt surgery for adult hydrocephalus.
  54. ncbi When is enlargement of the subarachnoid spaces not benign? A genetic perspective
    Alex R Paciorkowski
    Department of Genetics and Developmental Biology, Division of Human Genetics, University of Connecticut Health Center, West Hartford, Connecticut 06119, USA
    Pediatr Neurol 37:1-7. 2007
    ..This article reviews the events shaping the subarachnoid space, both during normal physiologic maturation and in specific genetic disorders...
  55. ncbi Benign extracerebral fluid collections in infancy: clinical presentation and long-term follow-up
    Leslie C Hellbusch
    Department of Surgery Neurosurgery, Nebraska Medical Center, Omaha, Nebraska 68114, USA
    J Neurosurg 107:119-25. 2007
    ..This study was undertaken to establish head size at birth, head size at presentation, head growth over time, history of presentation, indications for surgery, and long-term results...
  56. ncbi Demonstration of uneven distribution of intracranial pulsatility in hydrocephalus patients
    Per K Eide
    Department of Neurosurgery, Division of Clinical Neuroscience, Rikshospitalet, Oslo, Norway
    J Neurosurg 109:912-7. 2008
    Data from intracranial pressure (ICP) recordings in patients with hydrocephalus were reviewed to determine whether intracranial pulsatility within the cerebrospinal fluid (CSF) of cerebral ventricles (ICP(LV)) may differ from that within ..
  57. ncbi Apparent diffusion coefficient and cerebrospinal fluid flow measurements in patients with hydrocephalus
    Yonca Anik
    Department of Radiology, School of Medicine, Kocaeli University, Umuttepe, Kocaeli, Turkey
    J Comput Assist Tomogr 32:392-6. 2008
    To evaluate the efficacy of diffusion magnetic resonance imaging and compare with cerebrospinal fluid (CSF) flow imaging in patients with hydrocephalus before and after treatment.
  58. ncbi Infusion technique can be used to distinguish between dysfunction of a hydrocephalus shunt system and a progressive dementia
    A Eklund
    Department of Biomedical Engineering and Informatics, Umea University Hospital, Umea, Sweden
    Med Biol Eng Comput 42:644-9. 2004
    In a deteriorating shunted patient with hydrocephalus, an investigation of shunt function is often performed to distinguish a dysfunctioning shunt from an aggravated condition of the disease...
  59. ncbi Early experience from the application of a noninvasive magnetic resonance imaging-based measurement of intracranial pressure in hydrocephalus
    Roberta P Glick
    Department of Neurosurgery, Cook County Hospital and Rush University Medical Center, Chicago, Illinois, USA
    Neurosurgery 59:1052-60; discussion 1060-1. 2006
    ..CONCLUSION: A finding of a normal MR-ICP value in hydrocephalic patients presenting with symptoms suggestive of abnormal ICP is a strong predictor for resolution of symptoms or stable outcome without surgical intervention...
  60. ncbi Spontaneous third ventriculocisternostomy in an infant with obstructive hydrocephalus
    Gary L Gallia
    Center for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Randwick, New South Wales, Australia
    J Neurosurg Pediatr 1:477-80. 2008
    ..The authors report a case of an infant with obstructive hydrocephalus who developed a spontaneous third ventriculocisternostomy...
  61. ncbi Evaluation of the lumbar and ventricular infusion test in the diagnostic strategy of pediatric hydrocephalus and the therapeutic implications
    Tina Noergaard Munch
    University Clinic of Neurosurgery, Department 2092, The Neuroscience Centre, Rigshospitalet, 2100, Copenhagen, Denmark
    Childs Nerv Syst 23:67-71. 2007
    To evaluate the infusion test as a diagnostic tool behind the choice of intervention in pediatric hydrocephalus.
  62. ncbi The venous hypothesis of hydrocephalus
    Helen Williams
    Med Hypotheses 70:743-7. 2008
    ..Any increased in CNS tissue volumes can therefore lead to CSF accumulation. This may then exacerbate the hydrocephalus by further increasing overall CNS volume. Free flow of CSF around the CNS facilitates venous drainage...
  63. ncbi Relationship between shunt-dependent hydrocephalus after subarachnoid haemorrhage and duration of cerebrospinal fluid drainage
    K Ohwaki
    Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi, Tokyo, Japan
    Br J Neurosurg 18:130-4. 2004
    Subarachnoid haemorrhage (SAH) patients in Fisher group 3 have a high risk of vasospasm and chronic hydrocephalus. We have provided cisternal irrigation combined with a head-shaking method for preventing vasospasm in SAH patients...
  64. ncbi Lower incidence of reoperation with longer shunt survival with adult ventriculoperitoneal shunts placed for hemorrhage-related hydrocephalus
    Brian L Hoh
    Department of Neurological Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Neurosurgery 63:70-4; discussion 74-5. 2008
    ..We hypothesize that adult VPS placed for hemorrhage-related hydrocephalus have a lower incidence of reoperation than those placed for other types of hydrocephalus.
  65. ncbi Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning
    Hanna Siiskonen
    Department of Biotechnology Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Mol Cell Neurosci 34:199-208. 2007
    ..Our transgenic mouse line demonstrates that endogenously overexpressed DBI impairs hippocampus-dependent learning without anxiety or proconflict behavior...
  66. ncbi The syndrome of hydrocephalus in young and middle-aged adults (SHYMA)
    John A Cowan
    Department of Neurosurgery, Baltimore, MD, USA
    Neurol Res 27:540-7. 2005
    ..nausea/vomiting, visual changes, and altered mental status are accepted as indications for the evaluation of hydrocephalus in children; while dementia, gait apraxia, and urinary incontinence remain indications in the elderly...
  67. ncbi [Treatment of intraventricular hemorrhage and hydrocephalus]
    H B Huttner
    Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen
    Nervenarzt 79:1369-70, 1372-4, 1376. 2008
    ..The main concern is development of hydrocephalus, which is related to a poor prognosis...
  68. ncbi Cranioplasty for patients developing large cranial defects combined with post-traumatic hydrocephalus after head trauma
    G Li
    Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, PR, China
    Brain Inj 22:333-7. 2008
    Large cranial defects combined with hydrocephalus after decompressive craniectomy are a common, harsh reality among patients with head trauma. Typically, a shunt is first used to relieve the hydrocephalus...
  69. ncbi External hydrocephalus: a probable cause for subdural hematoma in infancy
    Sarit Ravid
    Division of Pediatric Neurology, Schneider Children's Hospital, New Hyde Park, NY 11040, USA
    Pediatr Neurol 28:139-41. 2003
    ..frontal subdural hematoma in association with prominent extracerebral cerebrospinal fluid spaces (external hydrocephalus). There was no history of trauma or risk factors for child abuse...
  70. ncbi Measurement of cerebrospinal fluid output through external ventricular drainage in one hundred infants and children: correlation with cerebrospinal fluid production
    Takasumi Yasuda
    Division of Pediatric Neurosurgery, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Ill. 60614, USA
    Pediatr Neurosurg 36:22-8. 2002
    OBJECTIVE: Cerebrospinal fluid (CSF) production rates influence shunt design and the care of children with hydrocephalus. Measurement of hourly CSF output through external ventricular drainage (EVD) reflects the CSF production...
  71. ncbi Neuroendoscopic third ventriculostomy for hydrocephalus in adults: report of a single unit's experience with 63 cases
    N Buxton
    Department of Neurosurgery, University Hospital, Nottingham, UK
    Surg Neurol 55:74-8. 2001
    BACKGROUND: Neuroendoscopic third ventriculostomy (NTV) is becoming a first line treatment for hydrocephalus in this center. Its use in a consecutive series of adults is reported...
  72. ncbi Neuroimaging findings in neonates and infants from superior vena cava obstruction after cardiac operation
    Boaz Karmazyn
    Department of Pediatric Radiology, Schneider Children s Medical Center of Israel, 14 Kaplan Street, Petah Tiqva 49202, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pediatr Radiol 32:806-10. 2002
    Extraventricular obstructive hydrocephalus may develop after superior vena cava obstruction, an uncommon complication after cardiac surgery.
  73. ncbi Benign enlargement of peripheral subarachnoid spaces in twins
    Apostolos H Karantanas
    Department of CT MRI, Larissa General Hospital, Larissa, Greece
    Comput Med Imaging Graph 26:47-8. 2002
    ..Literature research did not reveal such a case in twins nor has any association of the situation with any genetic or family predisposition been found...
  74. ncbi Differences in quantitative characteristics of intracranial pressure in hydrocephalic children treated surgically or conservatively
    Per Kristian Eide
    Department of Neurosurgery, The National Hospital, University of Oslo, Sognvannsveien 20, N 0027 Oslo, Norway
    Pediatr Neurosurg 36:304-13. 2002
    ..In children with hydrocephalus, the presentation of the ICP data as a matrix of ICP elevations of different levels and durations may enhance ..
  75. ncbi Quantitative assessment of cerebrospinal fluid hydrodynamics using a phase-contrast cine MR image in hydrocephalus
    D S Kim
    Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea
    Childs Nerv Syst 15:461-7. 1999
    ..Sixteen patients with obstructive hydrocephalus and 11 patients with normal pressure hydrocephalus (NPH) were investigated with the same sequence before and ..
  76. ncbi Simultaneous measurements of intracranial pressure parameters in the epidural space and in brain parenchyma in patients with hydrocephalus
    Per Kristian Eide
    Department of Neurosurgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Neurosurg 113:1317-25. 2010
    ..In this study, the authors compare simultaneous measurements of static and pulsatile pressure parameters in the epidural space and brain parenchyma of hydrocephalic patients...
  77. ncbi Single cell co-amplification of polymorphic markers for the indirect preimplantation genetic diagnosis of hemophilia A, X-linked adrenoleukodystrophy, X-linked hydrocephalus and incontinentia pigmenti loci on Xq28
    Nadine Gigarel
    , U393, , 75015 Paris, France
    Hum Genet 114:298-305. 2004
    ..gene-rich region encompassing disease genes such as haemophilia A, X-linked adrenoleukodystrophy, X-linked hydrocephalus and incontinentia pigmenti...
  78. ncbi L1 mediated homophilic binding and neurite outgrowth are modulated by alternative splicing of exon 2
    Jeffrey Jacob
    W M Keck Center for Collaborative Neuroscience, Rutgers University, 604 Allison Road, Piscataway, New Jersey 08854 8082, USA
    J Neurobiol 51:177-89. 2002
    ..The clinical importance of L1 is illustrated by pathological mutations that lead to hydrocephalus, mental retardation, motor defects, and early mortality...
  79. ncbi Longitudinal diffusion-weighted imaging in infants with hydrocephalus: decrease in tissue water diffusion after cerebrospinal fluid diversion
    Paul H Leliefeld
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    J Neurosurg Pediatr 4:56-63. 2009
    Progressive hydrocephalus may lead to edema of the periventricular white matter and to damage of the brain parenchyma because of compression, stretching, and ischemia...
  80. ncbi From congenital to idiopathic adult hydrocephalus: a historical research
    Paolo Missori
    Department of Neurological Sciences, Neurology and Neurosurgery, Sapienza, University of Rome, 00161, Italy
    Brain 133:1836-49. 2010
    Reports of idiopathic adult hydrocephalus prior to the 1965 description of idiopathic normal pressure hydrocephalus by Salomón Hakim and Raymond Adams are lacking in the literature...
  81. ncbi Is all "communicating" hydrocephalus really communicating? Prospective study on the value of 3D-constructive interference in steady state sequence at 3T
    A Dincer
    Acibadem University, School of Medicine, Department of Radiology, Istanbul, Turkey
    AJNR Am J Neuroradiol 30:1898-906. 2009
    ..The aim of this study was to investigate the additive value of 3D-CISS compared with conventional sequences in the diagnosis of obstructive membranes in hydrocephalus.
  82. ncbi Children with macrocrania: clinical and imaging predictors of disorders requiring surgery
    L S Medina
    Health Outcomes and Policy Section, Radiology Outcomes Center, Department of Radiology, Children's Hospital Medical Center, Cincinnati, OH, USA
    AJNR Am J Neuroradiol 22:564-70. 2001
    ..RESULTS: Sixteen (18%) of the patients had disorders requiring surgery: communicating hydrocephalus, n = 7; noncommunicating hydrocephalus, n = 3; hemorrhagic subdural collections, n = 3; neoplasm, n = 1; ..
  83. ncbi Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus
    Daniel Kondziella
    Department of Neurosciences, Norwegian University of Science and Technology, Trondheim, Norway
    J Neurochem 85:274-81. 2003
    The proper diagnosis of the arrested or the progressive form of hydrocephalus has a critical impact on treatment, but remains difficult...
  84. ncbi Acute hydrocephalus and cerebral perfusion after aneurysmal subarachnoid hemorrhage
    C J J van Asch
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands
    AJNR Am J Neuroradiol 31:67-70. 2010
    Acute hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH) may decrease cerebral perfusion by increasing intracranial pressure. We studied cerebral perfusion in patients with and without acute hydrocephalus after SAH.
  85. ncbi Randomized, controlled trial of acetazolamide and furosemide in posthemorrhagic ventricular dilation in infancy: follow-up at 1 year
    C R Kennedy
    Department of Pediatric Neurology, Southampton General Hospital, Southampton, England
    Pediatrics 108:597-607. 2001
    ..This article reports a multicenter, randomized, controlled trial designed to test the hypothesis that these drugs would reduce the rate of shunt placement (or death) and increase survival to 1 year of age without disability...
  86. ncbi Bedside external ventricular drain placement for the treatment of acute hydrocephalus
    B Z Roitberg
    Department of Neurosurgery M C799, University of Illinois at Chicago, 912 S Wood Street, Chicago, IL 60612, USA
    Br J Neurosurg 15:324-7. 2001
    ..study was to evaluate the results of external ventricular drain (EVD) placement for the management of hydrocephalus. We present our experience with 103 consecutive cases over one year, 56 of which had subarachnoid hemorrhage (..
  87. ncbi Monozygotic twins discordant for external hydrocephalus
    J H Piatt
    Section of Neurosurgery, St Christopher s Hospital For Children, and Department of Neurological Surgery, MCP Hahnemann University, Philadelphia, PA 19134 1095, USA
    Pediatr Neurosurg 35:211-5. 2001
    External hydrocephalus (EH) is a transient, developmental condition in infancy characterized by macrocephaly and prominence of the subarachnoid spaces...
  88. ncbi Ventriculomegaly and pericerebral CSF collection in the fetus: early stage of benign external hydrocephalus?
    N J Girard
    Department of Radiology, Hĵpital Nord, Marseille, France
    Childs Nerv Syst 17:239-45. 2001
    ..We report five cases that demonstrated benign external hydrocephalus postnatally, together with the prenatal MRI to define prenatal criteria of so-called benign external ..
  89. ncbi Neuroendoscopic management of hydrocephalus secondary to midline and pineal lesions
    S Cipri
    Operative Unit of Neurosurgery, Bianchi Melacrino Morelli Hospitals, Reggio Calabria, Italy
    J Neurosurg Sci 49:97-106. 2005
    ..Based on results of the recent literature, neuroendoscopic management of obstructive hydrocephalus, secondary to tumors of the pineal gland, has gained a preeminent role respect to shunting procedures.
  90. ncbi Repeat endoscopic third ventriculostomy: is it worth trying?
    V Siomin
    Dana Children s Hospital, Tel Aviv Sourasky Medical Center, Israel
    Childs Nerv Syst 17:551-5. 2001
    ..The goal of this study was to evaluate the safety, efficacy, and indications for repeat endoscopic third ventriculostomies (ETV)...
  91. ncbi Failure of cerebrospinal fluid shunts: part II: overdrainage, loculation, and abdominal complications
    Samuel R Browd
    Department of Neurosurgery, University of Utah, Primary Children's Medical Center, Salt Lake City, Utah 84113, USA
    Pediatr Neurol 34:171-6. 2006
    ..Familiarity with these types of shunt failure is essential for neurologists and pediatricians because they are often the first to evaluate and triage these children...
  92. ncbi An alternative approach for management of abdominal cerebrospinal fluid pseudocysts in children
    Ricardo Santos de Oliveira
    Division of Pediatric Neurosurgery, Ribeirao Preto School of Medicine, University of Sao Paulo, Campus Universitario, Sao Paulo, 14049 900, Brazil
    Childs Nerv Syst 23:85-90. 2007
    ..Retrospective data were obtained from 12 children treated with cerebrospinal fluid abdominal pseudocyst defined an alternative approach for management of these patients...
  93. ncbi Endoscopic third ventriculostomy for tumor-related hydrocephalus in a pediatric population
    Pulak Ray
    Division of Pediatric Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Neurosurg Focus 19:E8. 2005
    OBJECT: Endoscopic third ventriculostomy (ETV) has become a common alternative for managing hydrocephalus in select patients...
  94. ncbi Late rapid deterioration after endoscopic third ventriculostomy: additional cases and review of the literature
    James Drake
    Division of Neurosurgery, University of Toronto, Canada
    J Neurosurg 105:118-26. 2006
    ..Following the death at the University of Toronto of an additional patient who underwent surgery elsewhere, they canvassed pediatric neurosurgeons in North America, Europe, Australia, and Asia for additional cases...
  95. ncbi Atypical teratoid/rhabdoid tumor of the velum interpositum presenting as a spontaneous intraventricular hemorrhage in an infant: case report with long-term survival
    Daniel J Donovan
    Department of Surgery, Neurosurgery Service, Tripler Army Medical Center, Honolulu, Hawaii 96859 5000, USA
    Pediatr Neurosurg 42:187-92. 2006
    ..Spontaneous brain hemorrhage in a full-term infant requires a diligent and persistent search to rule out an underlying neoplasm...
  96. ncbi Endoscopic third ventriculostomy: an outcome analysis of primary cases and procedures performed after ventriculoperitoneal shunt malfunction
    Mohsen Javadpour
    Department of Neurosurgery, Royal Liverpool Children's Hospital NHS Trust, Liverpool, United Kingdom
    J Neurosurg 103:393-400. 2005
    OBJECT: The authors analyzed the role of endoscopic third ventriculostomy (ETV) as a primary treatment for hydrocephalus and also as an alternative to shunt revision for malfunctioning and infected ventriculoperitoneal (VP) shunts...
  97. ncbi Endoscopic treatment of hydrocephalus in children: a controlled study using newly developed Yamadori-type ventriculoscopes
    S Kamikawa
    Department of Neurosurgery, Kobe University School of Medicine, Kobe, Japan
    Minim Invasive Neurosurg 44:25-30. 2001
    Although cerebrospinal fluid (CSF) shunting is the most common neurosurgical treatment for hydrocephalus, the long-term results have still been unsatisfactory because of a wide variety of shunt complications...
  98. ncbi Endoscopic third ventriculostomy in children: early and late complications and their avoidance
    Ramon Navarro
    Department of Pediatric Neurosurgery, Hospital Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain
    Childs Nerv Syst 22:506-13. 2006
    ..is considered by many authors the initial surgical procedure of choice for the treatment of non-communicant hydrocephalus. However, this procedure has early and late complications that neurosurgeons must be aware of when performing ..
  99. ncbi Endoscopic cyst fenestration in the treatment of multiloculated hydrocephalus in children
    Nasser M F El-Ghandour
    Department of Neurosurgery, Cairo University, Cairo, Egypt
    J Neurosurg Pediatr 1:217-22. 2008
    The treatment of multiloculated hydrocephalus is a difficult problem in pediatric neurosurgery. Definitive treatment is surgical, yet the approach remains controversial...
  100. ncbi Endoscopic third ventriculostomy for the treatment of obstructive hydrocephalus during pregnancy
    Laurent Riffaud
    Department of Neurosurgery, Pontchaillou University Hospital, Rennes, France
    Obstet Gynecol 108:801-4. 2006
    Endoscopic third ventriculostomy is an effective procedure for treating obstructive (noncommunicating) hydrocephalus as an alternative to ventricular shunt placement.
  101. ncbi Prior CSF shunting increases the risk of endoscopic third ventriculostomy failure in the treatment of obstructive hydrocephalus in adults
    Graeme Woodworth
    The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Neurol Res 29:27-31. 2007
    Endoscopic third ventriculostomy (ETV) is accepted as an effective treatment for obstructive hydrocephalus (OHC); however, its benefit in patients previously treated with cerebrospinal fluid (CSF) shunting remains unclear...

Research Grants93

  1. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    Many neurological disorders, including hydrocephalus, result in brain injury and dysfunction in part through decreased cerebral blood flow (CBF)...
  2. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2009
    ..Clinical manifestations include seizures, hydrocephalus, and other symptoms associated with increased intra-cranial pressure...
  3. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    KATHLEEN SWEADNER; Fiscal Year: 2009
    ..Clinically when the outflow pathways are blocked, hydrocephalus (infants) or intracranial hypertension (adults) results...
  4. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2007
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  5. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  6. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2009
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  7. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  8. Conferene on the basic cell and molecular biology of cilia and flagella as relate
    Joel Rosenbaum; Fiscal Year: 2007
    ..basal bodies are involved in another new set of diseases, including Bardet Biedl Syndrome (BBS) and Congenital Hydrocephalus. The association between male fertility and defective sperm flagella has long been known, but only now are the ..
  9. FETAL MAGNETOENCEPHALOGRAPHY AND EVOKED POTENTIALS
    Curtis Lowery; Fiscal Year: 2000
    ..auditory and visual evoked field studies and baseline MEG studies on mothers with a prenatal diagnosis of hydrocephalus, neural tube defects, or chromosome abnormalities...
  10. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2007
    ..including retinal degeneration, immotilie cilia and Kartagener's syndromes, male and female infertility, hydrocephalus and anosmia, Bardet-Beidl syndrome and 1 of the most common genetic diseases in man, polycystic kidney disease...
  11. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..including retinal degeneration, immotilie cilia and Kartagener's syndromes, male and female infertility, hydrocephalus and anosmia, Bardet- Beidl syndrome and one of the most commongenetic diseases in man, polycystic kidney ..
  12. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    KATHLEEN SWEADNER; Fiscal Year: 2009
    ..Clinically when the outflow pathways are blocked, hydrocephalus (infants) or intracranial hypertension (adults) results...
  13. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    KATHLEEN SWEADNER; Fiscal Year: 2007
    ..Clinically when the outflow pathways are blocked, hydrocephalus (infants) or intracranial hypertension (adults) results...
  14. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    Kathleen J Sweadner; Fiscal Year: 2010
    ..Clinically when the outflow pathways are blocked, hydrocephalus (infants) or intracranial hypertension (adults) results...
  15. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Enhanced expression of FGF-2 and AVP in the CP-CSF system following ischemia and hydrocephalus suggests that peptides help to stabilize extracellular fluid volume and composition post-injury...
  16. Genetic Analysis of Mammalian CNS Development
    E Crenshaw; Fiscal Year: 2004
    ..Therefore, we are currently generating double knockouts of BMPR-IA and BMPR-IB to examine the role of type I BMP receptors during dorsal neural tube ontogeny. ..
  17. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2010
    ....
  18. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2010
    ....
  19. Centrosomin and Centrosomes in Cell Division
    TIMOTHY MEGRAW; Fiscal Year: 2009
    ....
  20. The Transport of Nutritional Heme in Animal Development
    Iqbal Hamza; Fiscal Year: 2010
    ..Knockdown of hrg-1 in zebrafish causes hydrocephalus, yolk tube defects, and anemia - phenotypes that are fully rescued by worm HRG-1...
  21. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    Tanja Godenschwege; Fiscal Year: 2009
    ..L1 have been shown to cause a variety of neurological disorders (CRASH syndrome) including mental retardation, hydrocephalus and spasticity. Nrg/L1 has been shown to be involved in axon pathfinding, neurite extension and cell migration...
  22. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    TANJA ANGELA GODENSCHWEGE; Fiscal Year: 2010
    ..L1 have been shown to cause a variety of neurological disorders (CRASH syndrome) including mental retardation, hydrocephalus and spasticity. Nrg/L1 has been shown to be involved in axon pathfinding, neurite extension and cell migration...
  23. OPENING OF THE BLOOD-BRAIN BARRIER TO ANTITUMOR AGENTS
    Edward A Neuwelt; Fiscal Year: 2010
    ..disseminated medulloblastoma in the leptomeninges and CSF, and will use novel imaging techniques to monitor hydrocephalus and chemotherapy efficacy...
  24. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2009
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  25. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2005
    ..Clinical manifestations include seizures, hydrocephalus, and other symptoms associated with increased intra-cranial pressure...
  26. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2007
    ..Clinical manifestations include seizures, hydrocephalus, and other symptoms associated with increased intra-cranial pressure...
  27. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2009
    ..As a consequence, defects in motility may result in impaired fertility, respiratory distress, hydrocephalus, and/or randomization of the left-right body axis...
  28. Conditional Deletion of Dnaic1 as a Model of Primary Ciliary Dyskinesia
    LAWRENCE OSTROWSKI; Fiscal Year: 2007
    ..And finally, in the available animal models of PCD, the animals develop hydrocephalus, making them unsuitable for studying pulmonary disease...
  29. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2007
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  30. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2009
    ..As a consequence, defects in motility may result in impaired fertility, respiratory distress, hydrocephalus, and/or randomization of the left-right body axis...
  31. PREVENTION OF BIOFILMS IN MEDICAL DEVICES
    Bhami Shenoy; Fiscal Year: 2003
    ..and testicular implants, artificial urinary sphincters, prostheses for hip and knee replacements, shunts for hydrocephalus, vascular grafts, heart valves, vascular access devices, voice prostheses, etc...
  32. Data Mining Based Noninvasive Intracranial Pressure Assessment
    Xiao Hu; Fiscal Year: 2007
    ..of DM NICP with two distinct patient population databases: traumatic brain injury (TBI) and normal pressure hydrocephalus (NPH)...
  33. Hydrocephalus, Intracranial Pressure and Neurocognition
    David Frim; Fiscal Year: 2006
    b>Hydrocephalus, a build-up of cerebrospinal fluid (CSF) in the intracranial space, is a disease that can cause significant neurological injury...
  34. Small Molecule Inhibitors of Cilia
    Wallace Marshall; Fiscal Year: 2007
    ..motile organelles that play critical roles in development and disease, including polycystic kidney disease, hydrocephalus, syndromic obesity, chronic sinusitis, bronchiectasis, and retinal degeneration...
  35. Flagellar Motility and Assemlby
    George Witman; Fiscal Year: 2007
    ..In the mouse and possibly in humans, Hydin defects cause hydrocephalus, which is the lethal accumulation of cerebrospinal fluid in the ventricles of the brain...
  36. GROWTH OF RETINAL GANGLION CELL AXONS
    Vance Lemmon; Fiscal Year: 2001
    ..Using our cDNA clones, other laboratories have shown that human X-linked hydrocephalus is due to a defect in L1 expression...
  37. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2005
    ..humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...