hydrocephalus

Summary

Summary: Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA (and in infants macrocephaly). This condition may be caused by obstruction of cerebrospinal fluid pathways due to neurologic abnormalities, INTRACRANIAL HEMORRHAGES; CENTRAL NERVOUS SYSTEM INFECTIONS; BRAIN NEOPLASMS; CRANIOCEREBRAL TRAUMA; and other conditions. Impaired resorption of cerebrospinal fluid from the arachnoid villi results in a communicating form of hydrocephalus. Hydrocephalus ex-vacuo refers to ventricular dilation that occurs as a result of brain substance loss from CEREBRAL INFARCTION and other conditions.

Top Publications

  1. ncbi Genetic disorders associated with macrocephaly
    Charles A Williams
    Raymond C Philips Research and Education Unit, Division of Genetics, Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    Am J Med Genet A 146:2023-37. 2008
  2. doi A contemporary definition and classification of hydrocephalus
    Harold L Rekate
    Department of Pediatric Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 16:9-15. 2009
  3. ncbi Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
    Nat Neurosci 13:700-7. 2010
  4. ncbi Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus
    Boglarka Banizs
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Development 132:5329-39. 2005
  5. ncbi Relationship between cerebrospinal fluid and blood dynamics in healthy volunteers and patients with communicating hydrocephalus
    Olivier Baledent
    Department of Imaging and Biophysics, UMR 6600 CNRS, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France
    Invest Radiol 39:45-55. 2004
  6. pmc Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus
    Marouan Abouhamed
    Institute of General Zoology and Genetics, Westfalian Wilhelms University, 48149 Munster, Germany
    Mol Biol Cell 20:5074-85. 2009
  7. ncbi Hydrocephalus in children born in 1999-2002: epidemiology, outcome and ophthalmological findings
    Eva Karin Persson
    Department of Paediatrics, Halmstad County Hospital, Halmstad, Sweden
    Childs Nerv Syst 23:1111-8. 2007
  8. ncbi The scientific history of hydrocephalus and its treatment
    A Aschoff
    University of Heidelberg, Department of Neurosurgery, Germany
    Neurosurg Rev 22:67-93; discussion 94-5. 1999
  9. ncbi A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells
    D Baas
    CGMC UMR 5534 CNRS, Universite Claude Bernard Lyon 1, 69622 Villeurbanne, France
    Eur J Neurosci 24:1020-30. 2006
  10. pmc Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior
    Yong Teng
    GHSU Cancer Center, School of Medicine, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 6:e24596. 2011

Detail Information

Publications382 found, 100 shown here

  1. ncbi Genetic disorders associated with macrocephaly
    Charles A Williams
    Raymond C Philips Research and Education Unit, Division of Genetics, Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    Am J Med Genet A 146:2023-37. 2008
    ..Some emphasis is placed on familial macrocephaly (sometimes referred to as benign external hydrocephalus) and on the macrocephaly associated with autism spectrum disorders...
  2. doi A contemporary definition and classification of hydrocephalus
    Harold L Rekate
    Department of Pediatric Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 16:9-15. 2009
    This review focuses on the problems related to defining hydrocephalus and on the development of a consensus on the classification of this common problem...
  3. ncbi Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
    Nat Neurosci 13:700-7. 2010
    ..development and planar organization of ependymal cilia are compromised, leading to defective CSF dynamics and hydrocephalus. In Celsr2 and Celsr3 double mutant ependyma, ciliogenesis is markedly impaired, resulting in lethal ..
  4. ncbi Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus
    Boglarka Banizs
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Development 132:5329-39. 2005
    ..include cystic kidney disease, biliary and pancreatic duct abnormalities, skeletal patterning defects, and hydrocephalus. Here, we explore the connection between cilia dysfunction and the development of hydrocephalus by using the ..
  5. ncbi Relationship between cerebrospinal fluid and blood dynamics in healthy volunteers and patients with communicating hydrocephalus
    Olivier Baledent
    Department of Imaging and Biophysics, UMR 6600 CNRS, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France
    Invest Radiol 39:45-55. 2004
    ..MRI), we investigated cerebral blood and cerebrospinal fluid (CSF) flows in patients with communicating hydrocephalus (CH) and in healthy volunteers to determine the contribution of CSF flow to brain pressure regulation in CH ..
  6. pmc Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus
    Marouan Abouhamed
    Institute of General Zoology and Genetics, Westfalian Wilhelms University, 48149 Munster, Germany
    Mol Biol Cell 20:5074-85. 2009
    ..IXa (Myo9a), an actin-dependent motor molecule with a Rho GTPase-activating (GAP) domain, develop severe hydrocephalus with stenosis and closure of the ventral caudal 3rd ventricle and the aqueduct...
  7. ncbi Hydrocephalus in children born in 1999-2002: epidemiology, outcome and ophthalmological findings
    Eva Karin Persson
    Department of Paediatrics, Halmstad County Hospital, Halmstad, Sweden
    Childs Nerv Syst 23:1111-8. 2007
    The purpose of this study was to monitor incidence and outcome in children with hydrocephalus.
  8. ncbi The scientific history of hydrocephalus and its treatment
    A Aschoff
    University of Heidelberg, Department of Neurosurgery, Germany
    Neurosurg Rev 22:67-93; discussion 94-5. 1999
    b>Hydrocephalus cases were regularly described by Hippocrates, Galen, and early and medieval Arabian physicians, who believed that this disease was caused by an extracerebral accumulation of water...
  9. ncbi A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells
    D Baas
    CGMC UMR 5534 CNRS, Universite Claude Bernard Lyon 1, 69622 Villeurbanne, France
    Eur J Neurosci 24:1020-30. 2006
    ..homeostasis in the mammalian brain, and defects in their differentiation or ciliated properties can lead to hydrocephalus. Regulatory factor X (RFX) transcription factors regulate genes required for ciliogenesis in the nematode, ..
  10. pmc Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior
    Yong Teng
    GHSU Cancer Center, School of Medicine, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 6:e24596. 2011
    ..Instead, the most striking phenotype involves significant enlargement of the ventricles (hydrocephalus). As shown for the lgi1a morphants, however, lgi1b morphants are also sensitized to PTZ-induced hyperactivity...
  11. doi Expression of HGF and VEGF in the cerebral tissue of adult rats with chronic hydrocephalus after subarachnoid hemorrhage
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, P R China
    Mol Med Rep 4:785-91. 2011
    ..aimed to investigate the role and expression of HGF and VEGF in the cerebral tissue of adult rats with chronic hydrocephalus after subarachnoid hemorrhage...
  12. pmc Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia
    Anu Sironen
    Biotechnology and Food Research, Animal Genomics, MTT Agrifood Research Finland, Jokioinen, Finland
    Biol Reprod 85:690-701. 2011
    ..for the mutation big giant head (bgh) have several abnormalities commonly associated with PCD, including hydrocephalus, male infertility, and sinusitis...
  13. ncbi Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes
    Elizabeth J Sweger
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:2309-17. 2007
    ..Surprisingly, we found that all transgenics expressing Ro1 developed hydrocephalus. We analyzed these mice in an effort to develop a new model of hydrocephalus that will further our ..
  14. ncbi Long-term follow-up data from the Shunt Design Trial
    J Kestle
    Division of Pediatric Neurosurgery, Primary Children s Medical Center, University of Utah, Salt Lake City, Utah, USA
    Pediatr Neurosurg 33:230-236. 2000
    ..The primary results were based on the patients' status as of October 31, 1996 (a minimum follow-up of 1 year). This report describes the late complications based on the patients' most recent follow-up...
  15. ncbi Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4
    Perry J Blackshear
    Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Development 130:4539-52. 2003
    ..transgene developed head swelling and rapid neurological decline in young adulthood, and had marked hydrocephalus of the lateral and third ventricles...
  16. doi A mechatronic valve in the management of hydrocephalus: methods and performance
    Lina Momani
    Department of Mechatronics Engineering, Faculty of Engineering Technology, Al Balqa Applied University, Al Salt, Jordan
    Med Biol Eng Comput 49:121-32. 2011
    The problem of excess cerebrospinal fluid in the brain (hydrocephalus) is generally managed using a passive pressure or flow regulated mechanical shunt...
  17. doi Endoscopic third ventriculostomy vs cerebrospinal fluid shunt in the treatment of hydrocephalus in children: a propensity score-adjusted analysis
    Abhaya V Kulkarni
    Division of Neurosurgery, Hospital for Sick Children, Room 1503, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Neurosurgery 67:588-93. 2010
    ..Endoscopic third ventriculostomy (ETV) has preferentially been offered to patients with more favorable prognostic features compared with shunt...
  18. ncbi Shunt revision for asymptomatic failure: surgical and clinical results
    Matthieu Vinchon
    Department of Pediatric Neurosurgery, Centre Hospitalier Regional et Universitaire de Lille, Lille, France
    Neurosurgery 52:347-53; discussion 353-6. 2003
    ..The goal of this study was to assess the effects of systematic follow-up monitoring and shunt revision for ASF; we reviewed our database to compare the results of shunt revision for ASF versus SSF...
  19. doi Costs and benefits of neurosurgical intervention for infant hydrocephalus in sub-Saharan Africa
    Benjamin C Warf
    Department of Neurosurgery, Children s Hospital Boston, Boston, MA, USA
    J Neurosurg Pediatr 8:509-21. 2011
    Evidence from the CURE Children's Hospital of Uganda (CCHU) suggests that treatment for hydrocephalus in infants can be effective and sustainable in a developing country...
  20. ncbi Disruption of the neurogenic niche in the subventricular zone of postnatal hydrocephalic hyh mice
    Antonio Jesús Jiménez
    Departamento de Biologia Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Málaga Málaga, Spain
    J Neuropathol Exp Neurol 68:1006-20. 2009
    ..In the animal model of human hydrocephalus, the hyh mouse, the ependyma of the lateral ventricles is progressively lost during late embryonic and early ..
  21. doi Pathomechanistic characterization of two exonic L1CAM variants located in trans in an obligate carrier of X-linked hydrocephalus
    Mariola Marx
    Institute of Anatomy and Cell Biology, Center for Neurosciences, University of Freiburg, Freiburg, Germany
    Neurogenetics 13:49-59. 2012
    ..We report here a family case of X-linked hydrocephalus in which an obligate female carrier has two exonic L1CAM missense mutations in trans substituting amino acids ..
  22. doi Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants
    Benjamin C Warf
    Department of Neurosurgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J Neurosurg Pediatr 8:502-8. 2011
    Neonatal infection is the most common cause of infant hydrocephalus in Uganda. Postinfectious hydrocephalus (PIH) is often accompanied by primary brain injury from the original infection...
  23. doi Plasmodium vivax malaria presenting with severe thrombocytopenia, cerebral complications and hydrocephalus
    Rekha Harish
    Department of Pediatrics, Government Medical College, Jammu, India
    Indian J Pediatr 76:551-2. 2009
    ..One had severe thrombocytopenia, massive intracranial bleed and hydrocephalus requiring shunt surgery while the other had gastrointestinal manifestations, encephalopathy and hydrocephalus...
  24. ncbi Do children with myelomeningocele and hydrocephalus display nonverbal learning disabilities? An empirical approach to classification
    Keith Owen Yeates
    Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA
    J Int Neuropsychol Soc 9:653-62. 2003
    As a group, children with myelomeningocele (MM) and early-onset hydrocephalus demonstrate many of the features of the syndrome of nonverbal learning disabilities (NLD)...
  25. doi Congenital hydrocephalus--prevalence, prenatal diagnosis and outcome of pregnancy in four European regions
    Ester Garne
    Paediatric Department, Kolding Hospital, DK 6000 Kolding, Denmark
    Eur J Paediatr Neurol 14:150-5. 2010
    To describe prevalence, prenatal diagnosis and outcome for fetuses and infants with congenital hydrocephalus.
  26. pmc A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice
    Alexis Tapanes-Castillo
    The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Lois Pope LIFE Center, Room 4 16, 1095 NW 14th Terrace, Miami, FL 33136, USA
    Neurogenetics 11:53-71. 2010
    Humans with L1 cell adhesion molecule (L1CAM) mutations exhibit X-linked hydrocephalus, as well as other severe neurological disorders...
  27. doi Neuroependymal denudation is in progress in full-term human foetal spina bifida aperta
    Deborah A Sival
    Departments of Pediatrics Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    Brain Pathol 21:163-79. 2011
    In human spina bifida aperta (SBA), cerebral pathogenesis [hydrocephalus, Sylvius aqueduct (SA) stenosis and heterotopias] is poorly understood...
  28. doi Treatment of traumatic acute subdural hematoma in adult hydrocephalus patients with cerebrospinal fluid shunt
    Katsumi Hoya
    Department of Neurosurgery, Dokkyo Medical University Koshigaya Hospital, 2 1 5 Minami Koshigaya, Koshigaya 343 8555, Japan
    Clin Neurol Neurosurg 114:211-6. 2012
    ..fluid (CSF) shunt is a predisposing factor for the development of subdural hematoma (SDH) in patients with hydrocephalus. However, few reports have addressed how patients with a CSF shunt should be treated in the event of traumatic ..
  29. ncbi Functional outcome in young adults with spina bifida and hydrocephalus
    R Hetherington
    Community Health and Knowledge Transfer, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5A 1X8, Canada
    Childs Nerv Syst 22:117-24. 2006
    ..Quality of life was studied in 31 adult survivors of spina bifida, each with Verbal or Performance IQ score over 70...
  30. ncbi The transition from child to adult in neurosurgery
    M Vinchon
    Pediatric Neurosurgery, Lille University Hospital, Lille Cedex, France
    Adv Tech Stand Neurosurg 32:3-24. 2007
    ..functional and social outcome of patients treated in our department for tumor of the central nervous system, hydrocephalus or myelomeningocele, and followed beyond the age of eighteen years...
  31. ncbi Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus
    M Czosnyka
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 94:482-6. 2001
    ..of both drainage and storage capacity become altered during the sequential pathological processes that lead to hydrocephalus. Cerebrospinal fluid (CSF) formation and drainage rate have been reported to be age dependent...
  32. doi Relation between TGF-beta 1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus
    Radim Lipina
    Department of Neurosurgery, University Hospital Ostrava, 17 listopadu 1790, Ostrava Poruba, 708 52, Czech Republic
    Childs Nerv Syst 26:333-41. 2010
    Therapy of posthaemorrhagic hydrocephalus (PHH) by using ventriculo-peritoneal drainage bears considerable rate of complications and remains a challenge in premature newborns...
  33. doi Headaches in patients with shunts
    Harold L Rekate
    Barrow Neurologic Institute, University of Arizona, College of Medicine, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 16:27-30. 2009
    ..in patients with shunts and, hopefully, the relationship of those headache disorders to the treatment of hydrocephalus. The Hydrocephalus Association maintains a self-reporting database recorded from individuals treated for ..
  34. ncbi Management of hydrocephalus in children with posterior fossa tumors: role of tumor surgery
    Bernt Johan Due-Tønnessen
    Department of Neurosurgery, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Pediatr Neurosurg 43:92-6. 2007
    The majority of children with posterior fossa tumors have hydrocephalus (HC) at the time of presentation. There is no consensus regarding the management of HC in these children...
  35. ncbi Long-term outcomes in patients with treated childhood hydrocephalus
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco 94102, USA
    J Neurosurg 106:334-9. 2007
    The goal in this study was to determine the long-term effects of childhood hydrocephalus.
  36. ncbi Magnetic field interactions in adjustable hydrocephalus shunts
    Andrea Lavinio
    United Kingdom Shunt Evaluation Laboratory, University of Cambridge, Cambridge, United Kingdom
    J Neurosurg Pediatr 2:222-8. 2008
    ..Shunt valves can also generate considerable imaging artifacts. The purpose of this study was to determine the magnetic field safety and MR imaging compatibility of 5 adjustable models of hydrocephalus shunts.
  37. ncbi Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene
    H K Hong
    Department of Genetics BRB 721 and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106 4955, USA
    Hum Mol Genet 8:625-37. 1999
    Congenital hydrocephalus is an etiologically diverse, poorly understood, but relatively common birth defect. Most human cases are sporadic with familial forms showing considerable phenotypic and etiologic heterogeneity...
  38. doi Lumbar catheter for monitoring of intracranial pressure in patients with post-hemorrhagic communicating hydrocephalus
    Verena Speck
    Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany
    Neurocrit Care 14:208-15. 2011
    We investigated the feasibility and accuracy of intracranial pressure (ICP)-measurement by lumbar drainage (LD) catheter in patients with post-hemorrhagic communicating hydrocephalus (PHCH).
  39. ncbi Outcome in pediatric hydrocephalus: a comparison between previously used outcome measures and the hydrocephalus outcome questionnaire
    Marc Platenkamp
    Department of Neurosurgery and Child Neurology, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Neurosurg 107:26-31. 2007
    The objectives of this study were to assess, in a cohort of children with recently treated hydrocephalus, the correlation between scores on the Hydrocephalus Outcome Questionnaire (HOQ) and the children's type of schooling and motor ..
  40. ncbi Time trends and demographics of deaths from congenital hydrocephalus in children in the United States: National Center for Health Statistics data, 1979 to 1998
    John H Chi
    Department of Neurological Surgery, University of California, San Francisco 94143 0112, USA
    J Neurosurg 103:113-8. 2005
    Congenital hydrocephalus has an estimated population incidence of 0.2 to 0.8/1000 live births...
  41. ncbi Vascular endothelial growth factor and transforming growth factor-beta1 are highly expressed in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus
    Axel Heep
    Department of Neonatology, University of Bonn, Adenauerallee 119, D 53113 Bonn, Germany
    Pediatr Res 56:768-74. 2004
    ..VEGF and TGF-beta1 was studied in the cerebrospinal fluid (CSF) of neonates with posthemorrhagic hydrocephalus (PHHC) and nonhemorrhagic hydrocephalus...
  42. ncbi Low-dose protocol for head CT in monitoring hydrocephalus in children
    Krzysztof Rybka
    Department of Diagnostic Imaging, Polish Mother s Memorial Hospital Research Institute, Łódź, Poland
    Med Sci Monit 13:147-51. 2007
    Children with hydrocephalus and increased intracranial pressure are treated with ventricular shunts. Multiple head CT is used to assess shunt malfunction and changes in ventricular size (volume)...
  43. ncbi Endoscopic management of hydrocephalus due to neurocysticercosis
    Jaime G Torres-Corzo
    Neurosurgery Deparment, Hospital Central Dr Ignacio Morones Prieto, Mexico
    Clin Neurol Neurosurg 112:11-6. 2010
    b>Hydrocephalus due to neurocysticercosis usually shows poor prognosis and shunt failure is a common complication. Neuroendoscopy has been suggested as treatment, but the indications remain unclear.
  44. ncbi Endoscopic third ventriculostomy: an outcome analysis of primary cases and procedures performed after ventriculoperitoneal shunt malfunction
    Donncha F O'Brien
    Department of Neurosurgery, Royal Liverpool Children s Hospital NHS Trust, Liverpool, United Kingdom
    J Neurosurg 103:393-400. 2005
    The authors analyzed the role of endoscopic third ventriculostomy (ETV) as a primary treatment for hydrocephalus and also as an alternative to shunt revision for malfunctioning and infected ventriculoperitoneal (VP) shunts.
  45. doi Ventriculoperitoneal shunt for hydrocephalus caused by central nervous system metastasis
    Seung Hoon Lee
    Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    J Neurooncol 104:545-51. 2011
    ..b>Hydrocephalus can result from CNS metastasis and frustrate cancer treatment...
  46. ncbi Index of cerebrospinal compensatory reserve in hydrocephalus
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, England
    Neurosurgery 64:494-501; discussion 501-2. 2009
    ..We explore how RAP varies with different forms of physiological or nonphysiological intracranial volume loads in adult hydrocephalus, with and without a functioning cerebrospinal fluid (CSF) shunt.
  47. doi Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model
    Leena Paul
    Burnett School of Biomedical Science, College of Medicine, University of Central Florida Orlando, Florida, USA
    Neurosurgery 68:462-73. 2011
    b>Hydrocephalus occurs because of an imbalance of bulk fluid flow in the brain, and aquaporins (AQPs) play pivotal roles in cerebral water movement as essential mediators during edema and fluid accumulation...
  48. pmc Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6
    Rossana Sapiro
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 22:6298-305. 2002
    ..Within 8 weeks of birth, approximately 50% of Spag6-deficient animals died with hydrocephalus. Spag6-deficient males surviving to maturity were infertile...
  49. ncbi Shunt surgery for hydrocephalus complicating cryptococcal meningitis in human immunodeficiency virus-negative patients
    Po Chou Liliang
    Department of Neurosurgery, Chang Gung Memorial Hospital, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan
    Clin Infect Dis 37:673-8. 2003
    From 1988 through 2001, 27 patients with cryptococcal meningitis who had hydrocephalus were identified and were treated by placement of ventriculoperitoneal (VP) shunts...
  50. ncbi Shunts vs endoscopic third ventriculostomy in infants: are there different types and/or rates of complications? A review
    C Di Rocco
    Pediatric Neurosurgical Unit, Catholic University, Largo A Gemelli, Rome, Italy
    Childs Nerv Syst 22:1573-89. 2006
    ..when we compare endoscopic third ventriculostomy (ETV) with shunts as surgical options for the treatment of hydrocephalus in infants is conditioned by the incidence of specific and shared complications of the two surgical procedures.
  51. ncbi Endocrine evaluation after endoscopic third ventriculostomy (ETV) in children
    M J Fritsch
    Department of Neurosurgery, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24105, Kiel, Germany
    Childs Nerv Syst 23:627-31. 2007
    Endoscopic third ventriculostomy (ETV) is a standard procedure for the treatment of obstructive hydrocephalus in children. Main part of the procedure is the perforation of the third ventricle floor (tuber cinereum)...
  52. doi Quality of life in children with hydrocephalus: results from the Hospital for Sick Children, Toronto
    Abhaya V Kulkarni
    Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 107:358-64. 2007
    Children with hydrocephalus face several quality of life (QOL) issues that have been poorly studied...
  53. ncbi Multilevel primary intraspinal PNETs in an infant associated with hydrocephalus
    Doga Gurkanlar
    Baskent University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey
    Turk Neurosurg 20:82-5. 2010
    ..we present a 40-day-old infant with multilevel primary spinal PNET at Th12-L1 and L5-S1 levels associated with hydrocephalus occurring nearly 15 days after the operation...
  54. ncbi Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus
    E Galbreath
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, USA
    J Neuropathol Exp Neurol 54:339-49. 1995
    ..Surprisingly, these mice developed severe hydrocephalus and died between birth and 3 weeks of age...
  55. ncbi Acute obstructive hydrocephalus and sudden death in children
    S Shemie
    Department of Critical Care Medicine, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Ann Emerg Med 29:524-8. 1997
    Sudden death from obstructive hydrocephalus related to intracranial neoplasms has rarely been reported in the pediatric literature...
  56. pmc A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus
    Joshua M Friedland-Little
    Department of Pediatrics, The University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA
    Hum Mol Genet 20:3725-37. 2011
    ..We identified atrioventricular canal 1 (avc1), a mouse mutation that caused VACTERL association with hydrocephalus, or VACTERL-H...
  57. ncbi A multicenter prospective cohort study of the Strata valve for the management of hydrocephalus in pediatric patients
    John R W Kestle
    Division of Pediatric Neurosurgery, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    J Neurosurg 102:141-5. 2005
    ..To evaluate these claims, the authors conducted a prospective multicenter cohort study of children who underwent placement of Strata valves...
  58. ncbi Matrix metalloproteinases in infants with posthemorrhagic hydrocephalus
    Toshio Okamoto
    Department of Pediatrics, Asahikawa Medical College, Asahikawa Kosei Hospital, Hokkaido 078 8510, Japan
    Early Hum Dev 84:137-9. 2008
    The cerebrospinal fluid matrix metalloproteinase (MMP) activities were measured in infants with posthemorrhagic hydrocephalus to elucidate the intrinsic mechanism for the resolution of ventricular dilation...
  59. pmc Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Box 1020, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 26:3764-72. 2006
    ..that a fraction of Cdo-/- mice from this background have additional defects in brain development, including hydrocephalus and cortical thinning. Primary neural progenitor cultures from E14...
  60. ncbi Shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage: incidence, predictors, and revision rates. Clinical article
    Cian J O'Kelly
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    J Neurosurg 111:1029-35. 2009
    Chronic shunt-dependent hydrocephalus is a recognized complication of aneurysmal subarachnoid hemorrhage...
  61. pmc Evidence that congenital hydrocephalus is a precursor to idiopathic normal pressure hydrocephalus in only a subset of patients
    Robin K Wilson
    Adult Hydrocephalus Program, Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurol Neurosurg Psychiatry 78:508-11. 2007
    To identify the proportion of patients in a large idiopathic normal pressure hydrocephalus (INPH) cohort with large head circumference (HC) who presumably have congenital hydrocephalus that has not become clinically apparent until late ..
  62. ncbi [Benign idiopathic external hydrocephalus (benign subdural collection) in 39 children: its natural history and relation to familial macrocephaly]
    M Castro-Gago
    Departamento de Pediatria, Hospital Clinico Universitario de Santiago de Compostela, La Choupana s n, E 15706 Santiago de Compostela, Spain
    Rev Neurol 40:513-7. 2005
    Benign idiopathic external hydrocephalus (BIEH) is an age-dependent disorder that is self-limiting in time and has an uncertain aetiology.
  63. ncbi Routine measurement of head circumference as a tool for detecting intracranial expansion in infants: what is the gain? A nationwide survey
    Sverre Morten Zahl
    Department of Surgery, Voss Hospital, Voss, Norway
    Pediatrics 121:e416-20. 2008
    ..The aim of the present study was to investigate the importance of routine head circumference measurements in the detection of intracranial expansive conditions, because only fragmented evidence exists in favor of this routine...
  64. ncbi Vision in children with hydrocephalus
    Susann Andersson
    Department of Ophthalmology, Institute of Clinical Neuroscience, The Sahlgrenska Academy of Göteborg University, Goteborg, Sweden
    Dev Med Child Neurol 48:836-41. 2006
    b>Hydrocephalus in children has many aetiologies, and can cause multiple ophthalmic and visual disorders...
  65. ncbi Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations
    E Parrini
    Research Institute, I R C C S, Stella Maris Foundation, University of Pisa, Italy
    Brain 129:1892-906. 2006
    ..and cerebellar hypoplasia, PNH with fronto-perisylvian or temporo-occipital polymicrogyria, posterior PNH with hydrocephalus, PNH with microcephaly, PNH with frontonasal dysplasia, PNH with limb abnormalities, PNH with fragile-X ..
  66. ncbi Macrocephaly, increased intracranial pressure, and hydrocephalus in the infant and young child
    Alexandra T Vertinsky
    Stanford University Medical Center, Stanford, CA, USA
    Top Magn Reson Imaging 18:31-51. 2007
    Macrocephaly, increased intracranial pressure, and hydrocephalus are common related conditions that lead to cross-sectional imaging of the infant and young child...
  67. ncbi Clinical and neuroradiological predictors of mortality in patients with primary pontine hemorrhage
    Kemal Balci
    Department of Neurology, School of Medicine, Trakya University, Edirne, Turkey
    Clin Neurol Neurosurg 108:36-9. 2005
    ..We aimed to evaluate the clinical and radiological predictors affecting the mortality in 32 patients with PPH...
  68. ncbi Factors related to hydrocephalus after aneurysmal subarachnoid hemorrhage
    Zeena Dorai
    Department of Neurosurgery, University of Texas at Southwestern Medical Center, Dallas 75390 8855, USA
    Neurosurgery 52:763-9; discussion 769-71. 2003
    The purpose of this study was to identify factors predictive of shunt-dependent hydrocephalus among patients with aneurysmal subarachnoid hemorrhage...
  69. doi Alterations of pulsation absorber characteristics in experimental hydrocephalus
    Eun Hyoung Park
    Department of Neurosurgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosurg Pediatr 6:159-70. 2010
    ..absorbance respond to changes in CSF movement under obstructive conditions such as the development of hydrocephalus? In the present study, chronic obstructive hydrocephalus was induced by the injection of cyanoacrylate gel ..
  70. ncbi Value of phase contrast magnetic resonance imaging for investigation of cerebral hydrodynamics
    O Baledent
    Department of Nuclear Medicine and Imaging, CHU Nord, Place Victor Pauchet, Amiens Cedex, France
    J Neuroradiol 33:292-303. 2006
    ..The objective of this paper is to describe the contribution of this technique in diseases related to disorders of cerebral hydrodynamics in the light of 5 clinical cases...
  71. doi Management of hydrocephalus in patients with tuberculous meningitis
    Vedantam Rajshekhar
    Department of Neurological Sciences, Christian Medical College, Vellore, India
    Neurol India 57:368-74. 2009
    b>Hydrocephalus is one of the commonest complications of tuberculous meningitis (TBM) occurring in up to 85% of children with the disease. It is more severe in children than in adults...
  72. pmc Who will care for me next? Transitioning to adulthood with hydrocephalus
    Tamara D Simon
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84113, USA
    Pediatrics 124:1431-7. 2009
    b>Hydrocephalus is a prototypical chronic condition that follows children into adulthood...
  73. pmc VEGF/VEGFR-2 changes in frontal cortex, choroid plexus, and CSF after chronic obstructive hydrocephalus
    Jun Yang
    Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, Cleveland Clinic, S 60, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Neurol Sci 296:39-46. 2010
    Chronic hydrocephalus (CH) is often associated with decreased cerebral blood flow (CBF) and oxygen levels...
  74. ncbi Cerebrovascular adaptation in chronic hydrocephalus
    M G Luciano
    Section of Pediatric and Congenital Neurosurgery, Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44118, USA
    J Cereb Blood Flow Metab 21:285-94. 2001
    This study characterizes the regional changes in vascularity, which accompanies chronic progressive hydrocephalus. Fifteen dogs underwent surgical induction of hydrocephalus and were used for histologic studies...
  75. ncbi CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1
    E Fransen
    Department of Medical Genetics, University of Antwerp, Belgium
    Eur J Hum Genet 3:273-84. 1995
    ..We review here the evidence that several X-linked mental retardation syndromes including X-linked hydrocephalus (HSAS), MASA syndrome, X-linked complicated spastic paraparesis (SP1) and X-linked corpus callosum agenesis (..
  76. ncbi Complications of endoscopic third ventriculostomy
    Henry W S Schroeder
    Department of Neurosurgery, Ernst Moritz Arndt University, Greifswald, Germany
    J Neurosurg 96:1032-40. 2002
    ..The purpose of this prospective investigation was to determine the rate of complications associated with endoscopic third ventriculostomy (ETV)...
  77. ncbi Disease-associated mutations in L1 CAM interfere with ligand interactions and cell-surface expression
    Elena De Angelis
    Cambridge Institute for Medical Research and Cambridge University Department of Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Hum Mol Genet 11:1-12. 2002
    Mutations in the L1CAM gene cause a highly variable neurological disease described as X-linked hydrocephalus, MASA syndrome or spastic paraplegia type I...
  78. ncbi Vascular endothelial growth factor and erythropoietin concentrations in cerebrospinal fluid of children with hydrocephalus
    Petra Koehne
    Klinik für Neonatologie, Charite Virchow Klinikum, 13344 Berlin, Germany
    Childs Nerv Syst 18:137-41. 2002
    ..We set up the hypothesis that elevated intracranial pressure in patients with hydrocephalus triggers release of VEGF and EPO into cerebrospinal fluid (CSF).
  79. pmc Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion
    Ira Adams-Chapman
    Department of Pediatrics Division of Neonatology, Emory University School of Medicine, 46 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
    Pediatrics 121:e1167-77. 2008
    ..We aimed to evaluate neurodevelopmental and growth outcomes among extremely low birth weight infants who had severe intraventricular hemorrhage that required shunt insertion compared with infants without shunt insertion...
  80. ncbi L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns
    E Fransen
    Department of Medical Genetics, University of Antwerp, B 2610 Antwerp, Belgium
    Hum Mol Genet 7:999-1009. 1998
    ..rise to a complex clinical picture, with mental retardation, neurologic abnormalities and a variable degree of hydrocephalus. Recently, a transgenic mouse model with a targeted null mutation in the L1 gene was generated...
  81. ncbi Radiological assessment of hydrocephalus: new theories and implications for therapy
    Dan Greitz
    Department of Neuroradiology and MR Research Center, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Neurosurg Rev 27:145-65; discussion 166-7. 2004
    It is almost a century since Dandy made the first experimental studies on hydrocephalus, but its underlying mechanism has been unknown up to now...
  82. ncbi Differences in cerebrospinal fluid dynamics do not affect the levels of biochemical markers in ventricular CSF from patients with aqueductal stenosis and idiopathic normal pressure hydrocephalus
    M Tisell
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Eur J Neurol 11:17-23. 2004
    ..cerebrospinal fluid (vCSF) between patients with aqueductal stenosis (AS) and idiopathic normal pressure hydrocephalus (INPH) and relate these results to clinical outcome after surgery...
  83. pmc The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice
    Hee Kyung Hong
    Howard Hughes Medical Institute, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 101:1748-53. 2004
    ..The hyh mutant provides a valuable in vivo model to study vesicle/membrane trafficking and provides insight into the potential roles of alpha-SNAP in embryogenesis and brain development...
  84. pmc The stumpy gene is required for mammalian ciliogenesis
    Terrence Town
    Department of Immunobiology and Neurobiology, Section of Nephrology, Yale University School of Medicine, 300 Cedar Street, TAC S 569, New Haven, CT 06519 8011, USA
    Proc Natl Acad Sci U S A 105:2853-8. 2008
    ..Stumpy was ubiquitously expressed, and conditional loss in mouse resulted in complete penetrance of perinatal hydrocephalus (HC) and severe polycystic kidney disease (PKD)...
  85. ncbi "Benign" extra-axial fluid in survivors of neonatal intensive care
    Scott A Lorch
    Center for Outcomes Research, Department of Neonatology, The Children s Hospital of Philadelphia, 3535 Market Street, Suite 1029, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 158:178-82. 2004
    ..To identify the prevalence of "benign" extra-axial fluid (BEAF), the risk factors associated with this condition, and the natural history in "graduates" of neonatal intensive care...
  86. doi Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus
    M E Wagshul
    Department of Radiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794 8460, USA
    Exp Neurol 218:33-40. 2009
    In communicating hydrocephalus (CH), explanations for the symptoms and clear-cut effective treatments remain elusive...
  87. ncbi Alterations in brain metabolism, CNS morphology and CSF dynamics in adult rats with kaolin-induced hydrocephalus
    Daniel Kondziella
    Department of Clinical Neuroscience, Faculty of Medicine, Olav Kyrresgt 3, N 7489 Trondheim, Norway
    Brain Res 927:35-41. 2002
    ..the biochemical changes, morphological development and the cerebrospinal fluid dynamics of the kaolin-induced hydrocephalus in the adult rat...
  88. ncbi Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus
    Gerald D Silverberg
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA
    J Neurosurg 97:1271-5. 2002
    The goal of this study was to determine the effect of hydrocephalus on cerebrospinal fluid (CSF) production rates in patients with acute and chronic hydrocephalus.
  89. ncbi Extent of acute hydrocephalus after aneurysmal subarachnoid hemorrhage as a risk factor for delayed cerebral infarction
    Annelies M Bakker
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 38:2496-9. 2007
    ..Cerebral perfusion is a predictor for DCI. Because acute hydrocephalus may impair cerebral perfusion, we evaluated the predictive value of the extent of acute hydrocephalus on the ..
  90. doi Management of hydrocephalus in infants by using shunts with adjustable valves
    Martin R Weinzierl
    Department of Neurosurgery, University Hospital RWTH, Aachen, Germany
    J Neurosurg Pediatr 2:14-8. 2008
    ..The goal of this prospective study was to assess the efficacy of valve adjustments in preventing slitlike ventricles in children < 6 months old after the first shunt insertion...
  91. ncbi Management of hydrocephalus associated with occipital encephalocoele using endoscopic third ventriculostomy: report of two cases
    Ranjith K Moorthy
    Department of Neurological Sciences, Christian Medical College Hospital, Vellore, India
    Surg Neurol 57:351-5; discussion 355. 2002
    ..encephalocoele is the most common cranial dysraphism in the western hemisphere and is often complicated by hydrocephalus. Management of hydrocephalus and reducing the CSF pressure is crucial in preventing dehiscence at the site of ..
  92. ncbi Posttraumatic hydrocephalus: a clinical, neuroradiologic, and neuropsychologic assessment of long-term outcome
    Letizia Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Turin, Italy
    Arch Phys Med Rehabil 84:1637-41. 2003
    To detect the clinical and radiologic characteristics of posttraumatic hydrocephalus (PTH), to define its prognostic value, and to assess the effects of shunt surgery.
  93. pmc Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages
    Paula Dietrich
    Department of Physiology, The University of Tennessee, Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 18:142-50. 2009
    ..Here we show that conditional inactivation of the Hdh gene in Wnt1 cell lineages results in congenital hydrocephalus, implicating huntingtin for the first time in the regulation of cerebral spinal fluid (CSF) homeostasis...
  94. ncbi Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain
    A N Tullio
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Comp Neurol 433:62-74. 2001
    Ablation of nonmuscle myosin heavy chain II-B (NMHC-B) in mice results in severe hydrocephalus with enlargement of the lateral and third ventricles. All B(-)/B(-) mice died either during embryonic development or on the day of birth (PO)...
  95. ncbi Long-term outcome in 109 adult patients operated on for hydrocephalus
    M Tisell
    Hydrocephalus Research Unit, Institute of Clinical Neuroscience, Sahlgrenska Academy at Goteborg University, Sweden
    Br J Neurosurg 20:214-21. 2006
    To examine the long-term effects of surgery in adult hydrocephalus we conducted a cross-sectional questionnaire study assessing both the patients' sense of well-being, and changes in gait, living conditions, daily need of sleep and ..
  96. pmc Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages
    Mitsunari Nakajima
    Department of Pharmaceutical Pharmacology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, 4 2 Bunkyo cho, Matsuyama 790 8578, Ehime, Japan
    Brain Res 1382:275-81. 2011
    ..Here we show that conditional inactivation of PS1 in Wnt1 cell lineages results in congenital hydrocephalus and subcommissural organ abnormalities, suggesting a possible role of PS1 in the regulation of cerebrospinal ..
  97. doi Visual field constriction in children with shunt-treated hydrocephalus
    Diana Rudolph
    Department of Pediatric Surgery, University of Leipzig, Germany
    J Neurosurg Pediatr 6:481-5. 2010
    Many ophthalmological abnormalities are described in conjunction with hydrocephalus. The results of visual field diagnosis remain a matter of further discussion...
  98. ncbi The expression of inherited hydrocephalus in H-Tx rats
    H C Jones
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville 32610, USA
    Childs Nerv Syst 16:578-84. 2000
    H-Tx rats develop severe hydrocephalus in late gestation. The breeding colony maintained at the University of Florida stems from one pair obtained in 1992...
  99. ncbi L1 mediated homophilic binding and neurite outgrowth are modulated by alternative splicing of exon 2
    Jeffrey Jacob
    W M Keck Center for Collaborative Neuroscience, Rutgers University, 604 Allison Road, Piscataway, New Jersey 08854 8082, USA
    J Neurobiol 51:177-89. 2002
    ..The clinical importance of L1 is illustrated by pathological mutations that lead to hydrocephalus, mental retardation, motor defects, and early mortality...
  100. ncbi Intracranial pressure monitoring with the Neurodur-P epidural sensor: a prospective study in patients with adult hydrocephalus or idiopathic intracranial hypertension
    Maria A Poca
    Department of Neurosurgery, Vall d Hebron University Hospital, Institut de Recerca Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    J Neurosurg 108:934-42. 2008
    ..The aim of this study was to assess the safety and accuracy of the Neurodur-P epidural sensor in the clinical setting...
  101. doi Cranioplasty for patients developing large cranial defects combined with post-traumatic hydrocephalus after head trauma
    G Li
    Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, PR, China
    Brain Inj 22:333-7. 2008
    Large cranial defects combined with hydrocephalus after decompressive craniectomy are a common, harsh reality among patients with head trauma. Typically, a shunt is first used to relieve the hydrocephalus...

Research Grants97

  1. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Many neurological disorders, including hydrocephalus, result in brain injury and dysfunction in part through decreased cerebral blood flow (CBF)...
  2. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2009
    ..Clinical manifestations include seizures, hydrocephalus, and other symptoms associated with increased intra-cranial pressure...
  3. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    KATHLEEN SWEADNER; Fiscal Year: 2009
    ..Clinically when the outflow pathways are blocked, hydrocephalus (infants) or intracranial hypertension (adults) results...
  4. Harness Germinal Matrix Hemorrhage
    John H Zhang; Fiscal Year: 2012
    ..Debilitating consequences of GMH include the formation of post- hemorrhagic hydrocephalus, leading to brain atrophy and neurological impairments...
  5. Improving Outcomes in Hydrocephalus: Bridging the Gap between Basic Science and C
    James McAllister; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Building on the impressive success of the NIH-sponsored workshop "Hydrocephalus: Myths, New Facts and Clear Directions" held in 2005, we propose a subsequent conference "Improving Outcome in ..
  6. Detection and Quantification of Neonatal Intraventricular Hemorrhage
    Michael D Weiss; Fiscal Year: 2012
    ..Adverse neurodevelopmental sequelae include cerebral palsy, seizures, posthemorrhagic hydrocephalus (which may require a ventriculoperitoneal shunt), blindness, deafness, and cognitive impairment (Hintz and O&..
  7. Improving CBF through direct control of CSF pulsations
    Mark Luciano; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Many neurological disorders, including hydrocephalus, result in brain injury and dysfunction in part through decreased cerebral blood flow (CBF)...
  8. Characterization of a novel murine model of central nervous system catheter infec
    Jessica Snowden; Fiscal Year: 2010
    ..Cerebrospinal fluid (CSF) shunt infections are a frequent and serious complication in the treatment of hydrocephalus in the pediatric population, with a reported incidence of 5-15%1...
  9. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark Fisher; Fiscal Year: 1990
    ..by repeated neurological evaluations; 2) Arteriographic, as determined by the presence of vasospasm; 3) Hydrocephalus, as determined by CT scan; 4) Platelete activation and other elements of the coagulation system, as determined ..
  10. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  11. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2009
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  12. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2007
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  13. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Detrimental ISF-CSF interactions may exacerbate aging as well as normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD)...
  14. Conferene on the basic cell and molecular biology of cilia and flagella as relate
    Joel Rosenbaum; Fiscal Year: 2007
    ..basal bodies are involved in another new set of diseases, including Bardet Biedl Syndrome (BBS) and Congenital Hydrocephalus. The association between male fertility and defective sperm flagella has long been known, but only now are the ..
  15. RADIOLOGIC ASPECTS OF CEREBROSPINAL FLUID ABSORPTION
    Daniel Gomez; Fiscal Year: 1990
    ..While blocks in the basal cisterns and those in the fourth ventricle induce hydrocephalus, it is uncertain whether specific blocks in the other locations will induce ventricular enlargement...
  16. FETAL MAGNETOENCEPHALOGRAPHY AND EVOKED POTENTIALS
    Curtis Lowery; Fiscal Year: 1999
    ..auditory and visual evoked field studies and baseline MEG studies on mothers with a prenatal diagnosis of hydrocephalus, neural tube defects, or chromosome abnormalities...
  17. FETAL MAGNETOENCEPHALOGRAPHY AND EVOKED POTENTIALS
    Curtis Lowery; Fiscal Year: 2000
    ..auditory and visual evoked field studies and baseline MEG studies on mothers with a prenatal diagnosis of hydrocephalus, neural tube defects, or chromosome abnormalities...
  18. Implantable Microdevice for the Treatment of Hydrocephalus
    HONGSEOK NOH; Fiscal Year: 2009
    ..When the AGs do not function properly this dynamic equilibrium is altered and the pathologic condition of hydrocephalus ensues...
  19. Implantable Microdevice for the Treatment of Hydrocephalus
    HONGSEOK NOH; Fiscal Year: 2009
    ..When the AGs do not function properly this dynamic equilibrium is altered and the pathologic condition of hydrocephalus ensues...
  20. The UAB Spina Bifida Patient Registry Demonstration Project
    David B Joseph; Fiscal Year: 2010
    ..Children born with Spina Bifida face a number of obstacles including hydrocephalus in more that 90% of cases, as well as paralysis and weakness of the extremities and decreased bladder/bowel ..
  21. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2006
    ..including retinal degeneration, immotilie cilia and Kartagener's syndromes, male and female infertility, hydrocephalus and anosmia, Bardet-Beidl syndrome and 1 of the most common genetic diseases in man, polycystic kidney disease...
  22. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..including retinal degeneration, immotilie cilia and Kartagener's syndromes, male and female infertility, hydrocephalus and anosmia, Bardet- Beidl syndrome and one of the most commongenetic diseases in man, polycystic kidney ..
  23. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2007
    ..including retinal degeneration, immotilie cilia and Kartagener's syndromes, male and female infertility, hydrocephalus and anosmia, Bardet-Beidl syndrome and 1 of the most common genetic diseases in man, polycystic kidney disease...
  24. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..including retinal degeneration, immotilie cilia and Kartagener's syndromes, male and female infertility, hydrocephalus and anosmia, Bardet- Beidl syndrome and one of the most commongenetic diseases in man, polycystic kidney ..
  25. The UAB Spina Bifida Patient Registry Demonstration Project
    David Joseph; Fiscal Year: 2009
    ..Children born with Spina Bifida face a number of obstacles including hydrocephalus in more that 90% of cases, as well as paralysis and weakness of the extremities and decreased bladder/bowel ..
  26. L1 SIGNALING IN X-LINKED MENTAL RETARDATION
    Patricia Maness; Fiscal Year: 2000
    DESCRIPTION: Several X-linked mental retardation syndromes including hydrocephalus, MASA syndrome, agenesis of the corpus callosum and corticopinal tract and spastic paraparesis are caused by mutations in the gene encoding L1, a neural ..
  27. L1 SIGNALING IN X-LINKED MENTAL RETARDATION
    Patricia Maness; Fiscal Year: 1999
    DESCRIPTION: Several X-linked mental retardation syndromes including hydrocephalus, MASA syndrome, agenesis of the corpus callosum and corticopinal tract and spastic paraparesis are caused by mutations in the gene encoding L1, a neural ..
  28. Long Term Implantable ICP Monitor for Hydrocephalus Patients
    Marek Swoboda; Fiscal Year: 2012
    ..ICPCheck, the first long term implantable, non-invasively readable intracranial pressure (ICP) monitor for hydrocephalus patients...
  29. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    KATHLEEN SWEADNER; Fiscal Year: 2007
    ..Clinically when the outflow pathways are blocked, hydrocephalus (infants) or intracranial hypertension (adults) results...
  30. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    KATHLEEN SWEADNER; Fiscal Year: 2009
    ..Clinically when the outflow pathways are blocked, hydrocephalus (infants) or intracranial hypertension (adults) results...
  31. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    Kathleen J Sweadner; Fiscal Year: 2010
    ..Clinically when the outflow pathways are blocked, hydrocephalus (infants) or intracranial hypertension (adults) results...
  32. ALCOHOL INTERACTION WITH L1 CELL ADHESION MOLECULE
    MICHAEL CHARNESS; Fiscal Year: 1999
    ..Mental retardation, hydrocephalus, and agenesis of the corpus callosum are observed both in fetal alcohol syndrome (FAS) and in children with ..
  33. GAIT DISTURBANCES IN THE ELDERLY--INITIATION OF GAIT
    Rodger Elble; Fiscal Year: 1992
    ..g., Binswanger disease and normal pressure hydrocephalus), but may be seen in other conditions (e.g., Alzheimer disease)...
  34. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 1999
    ..Enhanced expression of FGF-2 and AVP in the CP-CSF system following ischemia and hydrocephalus suggests that peptides help to stabilize extracellular fluid volume and composition post-injury...
  35. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2000
    ..Enhanced expression of FGF-2 and AVP in the CP-CSF system following ischemia and hydrocephalus suggests that peptides help to stabilize extracellular fluid volume and composition post-injury...
  36. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Enhanced expression of FGF-2 and AVP in the CP-CSF system following ischemia and hydrocephalus suggests that peptides help to stabilize extracellular fluid volume and composition post-injury...
  37. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2001
    ..Enhanced expression of FGF-2 and AVP in the CP-CSF system following ischemia and hydrocephalus suggests that peptides help to stabilize extracellular fluid volume and composition post-injury...
  38. Genetic Analysis of Mammalian CNS Development
    E Crenshaw; Fiscal Year: 2001
    ..Therefore, we are currently generating double knockouts of BMPR-IA and BMPR-IB to examine the role of type I BMP receptors during dorsal neural tube ontogeny. ..
  39. Genetic Analysis of Mammalian CNS Development
    E Crenshaw; Fiscal Year: 2001
    ..Therefore, we are currently generating double knockouts of BMPR-IA and BMPR-IB to examine the role of type I BMP receptors during dorsal neural tube ontogeny. ..
  40. Genetic Analysis of Mammalian CNS Development
    E Crenshaw; Fiscal Year: 2002
    ..Therefore, we are currently generating double knockouts of BMPR-IA and BMPR-IB to examine the role of type I BMP receptors during dorsal neural tube ontogeny. ..
  41. Genetic Analysis of Mammalian CNS Development
    E Crenshaw; Fiscal Year: 2004
    ..Therefore, we are currently generating double knockouts of BMPR-IA and BMPR-IB to examine the role of type I BMP receptors during dorsal neural tube ontogeny. ..
  42. Genetic Analysis of Mammalian CNS Development
    E Crenshaw; Fiscal Year: 2003
    ..Therefore, we are currently generating double knockouts of BMPR-IA and BMPR-IB to examine the role of type I BMP receptors during dorsal neural tube ontogeny. ..
  43. Regulators of Centriole Duplication and Structure
    Kevin C Slep; Fiscal Year: 2010
    ..formation including, but not limited to, Down syndrome, retinitis pigmentosa, polydactyly, situs inversus, hydrocephalus, obesity, and Bardet-Biedl syndrome...
  44. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2010
    ....
  45. Centrosomin and Centrosomes in Cell Division
    TIMOTHY MEGRAW; Fiscal Year: 2009
    ....
  46. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2010
    ....
  47. The Transport of Nutritional Heme in Animal Development
    Iqbal Hamza; Fiscal Year: 2010
    ..Knockdown of hrg-1 in zebrafish causes hydrocephalus, yolk tube defects, and anemia - phenotypes that are fully rescued by worm HRG-1...
  48. High School Student NeuroResearch Program (HSNRP)
    MARLYS HEARST contact WITTE; Fiscal Year: 2011
    ..including Parkinson, Alzheimer, Niemann-Pick C diseases, ALS, epilepsy, HIV encephalopathy, head trauma, hydrocephalus, muscular dystrophy, pain/ addiction pharmacology, molecular psychiatry, cognition, brain development, ..
  49. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    TANJA ANGELA GODENSCHWEGE; Fiscal Year: 2010
    ..L1 have been shown to cause a variety of neurological disorders (CRASH syndrome) including mental retardation, hydrocephalus and spasticity. Nrg/L1 has been shown to be involved in axon pathfinding, neurite extension and cell migration...
  50. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    Tanja Godenschwege; Fiscal Year: 2009
    ..L1 have been shown to cause a variety of neurological disorders (CRASH syndrome) including mental retardation, hydrocephalus and spasticity. Nrg/L1 has been shown to be involved in axon pathfinding, neurite extension and cell migration...
  51. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    Tanja Godenschwege; Fiscal Year: 2009
    ..L1 have been shown to cause a variety of neurological disorders (CRASH syndrome) including mental retardation, hydrocephalus and spasticity. Nrg/L1 has been shown to be involved in axon pathfinding, neurite extension and cell migration...
  52. Mechanisms of early brain injury after subarachnoid hemmorrhage
    Guohua Xi; Fiscal Year: 2012
    ..Aims: 1) To determine whether deferoxamine attenuates SAH-induced brain edema, blood-brain barrier disruption, hydrocephalus and vasospasm, major factors in SAH outcome;2) To determine whether blocking complement activation reduces ..
  53. OPENING OF THE BLOOD-BRAIN BARRIER TO ANTITUMOR AGENTS
    Edward A Neuwelt; Fiscal Year: 2010
    ..disseminated medulloblastoma in the leptomeninges and CSF, and will use novel imaging techniques to monitor hydrocephalus and chemotherapy efficacy...
  54. RADIOLOGIC ASPECTS OF CEREBROSPINAL FLUID ABSORPTION
    Daniel Gomez; Fiscal Year: 1980
    ..morphologic observations of the arachnoid granulations and adjacent structures in human autopsy material with hydrocephalus and related diseases. Radiological, physiological and morphological techniques will be used for these studies.
  55. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2007
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  56. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2004
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  57. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2009
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  58. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2005
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  59. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2003
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  60. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2006
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  61. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2006
    ..Clinical manifestations include seizures, hydrocephalus, and other symptoms associated with increased intra-cranial pressure...
  62. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2005
    ..Clinical manifestations include seizures, hydrocephalus, and other symptoms associated with increased intra-cranial pressure...
  63. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..range of cell types and play critical roles in development and disease, including polycystic kidney disease, hydrocephalus, syndromic obesity, and retinal degeneration...
  64. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2005
    ..Clinical manifestations include seizures, hydrocephalus, and other symptoms associated with increased intra-cranial pressure...
  65. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 2007
    ..Clinical manifestations include seizures, hydrocephalus, and other symptoms associated with increased intra-cranial pressure...
  66. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2009
    ..range of cell types and play critical roles in development and disease, including polycystic kidney disease, hydrocephalus, syndromic obesity, and retinal degeneration...
  67. Conditional Deletion of Dnaic1 as a Model of Primary Ciliary Dyskinesia
    LAWRENCE OSTROWSKI; Fiscal Year: 2006
    ..And finally, in the available animal models of PCD, the animals develop hydrocephalus, making them unsuitable for studying pulmonary disease...
  68. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2009
    ..As a consequence, defects in motility may result in impaired fertility, respiratory distress, hydrocephalus, and/or randomization of the left-right body axis...
  69. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2007
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  70. Conditional Deletion of Dnaic1 as a Model of Primary Ciliary Dyskinesia
    LAWRENCE OSTROWSKI; Fiscal Year: 2007
    ..And finally, in the available animal models of PCD, the animals develop hydrocephalus, making them unsuitable for studying pulmonary disease...
  71. Calcium regulation of flagellar motility
    Elizabeth Smith; Fiscal Year: 2009
    ..As a consequence, defects in motility may result in impaired fertility, respiratory distress, hydrocephalus, and/or randomization of the left-right body axis...
  72. PREVENTION OF BIOFILMS IN MEDICAL DEVICES
    Bhami Shenoy; Fiscal Year: 2003
    ..and testicular implants, artificial urinary sphincters, prostheses for hip and knee replacements, shunts for hydrocephalus, vascular grafts, heart valves, vascular access devices, voice prostheses, etc...
  73. A MEMS intracranial pressure device for monitoring brain injuries and disorders
    NIKOLAOS CHRONIS; Fiscal Year: 2009
    ..g. traumatic brain injuries (TBIs)) and cerebrospinal fluid outflow disorders (e.g. hydrocephalus). Clinical trials have shown that ICP monitoring decreases the mortality rate and minimizes secondary injuries...
  74. A MEMS intracranial pressure device for monitoring brain injuries and disorders
    NIKOLAOS CHRONIS; Fiscal Year: 2010
    ..g. traumatic brain injuries (TBIs)) and cerebrospinal fluid outflow disorders (e.g. hydrocephalus). Clinical trials have shown that ICP monitoring decreases the mortality rate and minimizes secondary injuries...
  75. GENERAL CLINICAL RESEARCH CENTER
    LEONARD NAPOLITANO; Fiscal Year: 1993
    ..cerebral ventricular volume in premature infants and relationship to clinical intervention for posthemorrhagic hydrocephalus in infants of minority women...
  76. Data Mining Based Noninvasive Intracranial Pressure Assessment
    Xiao Hu; Fiscal Year: 2007
    ..of DM NICP with two distinct patient population databases: traumatic brain injury (TBI) and normal pressure hydrocephalus (NPH)...
  77. Hydrocephalus, Intracranial Pressure and Neurocognition
    David Frim; Fiscal Year: 2006
    b>Hydrocephalus, a build-up of cerebrospinal fluid (CSF) in the intracranial space, is a disease that can cause significant neurological injury...
  78. Small Molecule Inhibitors of Cilia
    Wallace Marshall; Fiscal Year: 2007
    ..motile organelles that play critical roles in development and disease, including polycystic kidney disease, hydrocephalus, syndromic obesity, chronic sinusitis, bronchiectasis, and retinal degeneration...
  79. ShuntCheck Clinical Validation and ShuntCheck-Micro-Pumper Assessment of CSF Shun
    Marek Swoboda; Fiscal Year: 2010
    ..b>Hydrocephalus is a common condition in which CSF accumulates in the brain ventricles, potentially leading to brain damage ..
  80. Hydrocephalus, Intracranial Pressure and Neurocognition
    David Frim; Fiscal Year: 2003
    b>Hydrocephalus, a build-up of cerebrospinal fluid (CSF) in the intracranial space, is a disease that can cause significant neurological injury...
  81. Hydrocephalus, Intracranial Pressure and Neurocognition
    David Frim; Fiscal Year: 2004
    b>Hydrocephalus, a build-up of cerebrospinal fluid (CSF) in the intracranial space, is a disease that can cause significant neurological injury...
  82. Hydrocephalus, Intracranial Pressure and Neurocognition
    David Frim; Fiscal Year: 2005
    b>Hydrocephalus, a build-up of cerebrospinal fluid (CSF) in the intracranial space, is a disease that can cause significant neurological injury...
  83. GROWTH OF RETINAL GANGLION CELL AXONS
    Vance Lemmon; Fiscal Year: 1999
    ..Using our cDNA clones, other laboratories have shown that human X-linked hydrocephalus is due to a defect in L1 expression...
  84. GROWTH OF RETINAL GANGLION CELL AXONS
    Vance Lemmon; Fiscal Year: 2001
    ..Using our cDNA clones, other laboratories have shown that human X-linked hydrocephalus is due to a defect in L1 expression...
  85. Flagellar Motility and Assemlby
    George Witman; Fiscal Year: 2009
    ..In the mouse and possibly in humans, Hydin defects cause hydrocephalus, which is the lethal accumulation of cerebrospinal fluid in the ventricles of the brain...
  86. GROWTH OF RETINAL GANGLION CELL AXONS
    Vance Lemmon; Fiscal Year: 2000
    ..Using our cDNA clones, other laboratories have shown that human X-linked hydrocephalus is due to a defect in L1 expression...
  87. Flagellar Motility and Assemlby
    George Witman; Fiscal Year: 2007
    ..In the mouse and possibly in humans, Hydin defects cause hydrocephalus, which is the lethal accumulation of cerebrospinal fluid in the ventricles of the brain...
  88. Flagellar Motility and Assemlby
    George Witman; Fiscal Year: 2009
    ..In the mouse and possibly in humans, Hydin defects cause hydrocephalus, which is the lethal accumulation of cerebrospinal fluid in the ventricles of the brain...
  89. Flagellar Motility and Assemlby
    George B Witman; Fiscal Year: 2010
    ..In the mouse and possibly in humans, Hydin defects cause hydrocephalus, which is the lethal accumulation of cerebrospinal fluid in the ventricles of the brain...
  90. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2002
    ..humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  91. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2003
    ..humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  92. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2003
    ..humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  93. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2005
    ..humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  94. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2004
    ..humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  95. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2001
    ..humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...