pancreas

Summary

Summary: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.

Top Publications

  1. Mandemakers W, Abuhatzira L, Xu H, Caromile L, Hébert S, Snellinx A, et al. Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 ?: identification of miR-153 target genes with functions related to IA-2? in pancreas and brain. Diabetologia. 2013;56:1547-56 pubmed publisher
    ..We also identified miR-153 target genes that correlated with IA-2? localisation and function...
  2. Badole S, Mahamuni S, Bagul P, Khose R, Joshi A, Ghule A, et al. Cycloart-23-ene-3?, 25-diol stimulates GLP-1 (7-36) amide secretion in streptozotocin-nicotinamide induced diabetic Sprague Dawley rats: a mechanistic approach. Eur J Pharmacol. 2013;698:470-9 pubmed publisher
    ..It decreased plasma glucose level, increased plasma and pancreatic insulin level as well as increased plasma and colonic active GLP-1 (7-36) amide secretion in streptozotocin-nicotinamide induced diabetic Sprague Dawley rats...
  3. Barral M, Soyer P, Ben Hassen W, Gayat E, Aout M, Chiaradia M, et al. Diffusion-weighted MR imaging of the normal pancreas: reproducibility and variations of apparent diffusion coefficient measurement at 1.5- and 3.0-Tesla. Diagn Interv Imaging. 2013;94:418-27 pubmed publisher
    ..To evaluate reproducibility and variations in apparent diffusion coefficient (ADC) measurement in normal pancreatic parenchyma at 1.5- and 3.0-Tesla and determine if differences may exist between the four pancreatic segments...
  4. Provost E, Wehner K, Zhong X, Ashar F, Nguyen E, Green R, et al. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development. 2012;139:3232-41 pubmed publisher
    ..The pancreatic phenotypes observed in rpl3- and pes-deficient embryos were also independent of p53. Together, these data suggest novel p53-independent roles for ribosomal biogenesis genes in zebrafish pancreas development.
  5. Alexandre M, Uduman A, Minervini S, Raoof A, Shugrue C, Akinbiyi E, et al. Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses. Am J Physiol Gastrointest Liver Physiol. 2012;303:G696-704 pubmed publisher
    ..These studies suggest that prolonged exposure to this tobacco toxin can cause pancreatitis and sensitize to disease. Therapies targeting NNK-mediated pathways may prove useful in treatment of smoking-related pancreatitis...
  6. Lanzoni G, Oikawa T, Wang Y, Cui C, Carpino G, Cardinale V, et al. Concise review: clinical programs of stem cell therapies for liver and pancreas. Stem Cells. 2013;31:2047-60 pubmed publisher
    ..We summarize those for liver and pancreas, organs that share endodermal stem cell populations, biliary tree stem cells (hBTSCs), located in peribiliary ..
  7. Magnuson M, Osipovich A. Pancreas-specific Cre driver lines and considerations for their prudent use. Cell Metab. 2013;18:9-20 pubmed publisher
    ..We also discuss preferred strategies for achieving high-fidelity driver lines and remind investigators of the continuing need for caution when interpreting results obtained from any Cre/LoxP-based experiment performed in mice. ..
  8. Bosco C, Díaz E, Gutiérrez R, Gonzalez J, Pérez J. Ganglionar nervous cells and telocytes in the pancreas of Octodon degus: extra and intrapancreatic ganglionar cells and telocytes in the degus. Auton Neurosci. 2013;177:224-30 pubmed publisher
    ..extrapancreatic ganglionar neurons and telocytes in Octodon degus such as those described in human and guinea pig pancreas. Pancreatic ganglionar neurons were identified by their histological characteristics as well as their positive ..
  9. Maglione M, Cardini B, Oberhuber R, Watschinger K, Jenny M, Gostner J, et al. Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin. Transpl Int. 2012;25:1084-95 pubmed publisher
    ..These results show a striking superiority of tetrahydrobiopterin in preventing lethal IRI compared with related compounds and suggest nitric oxide synthases as treatment target...

More Information

Publications62

  1. Drucker D. Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes. 2013;62:3316-23 pubmed publisher
    ..localization of incretin receptor expression in pancreatic ductal or acinar cells in normal or diabetic human pancreas is challenging because antisera used for detection of the GLP-1 receptor often are neither sufficiently sensitive ..
  2. Li H, Kapoor A, Giel Moloney M, Rindi G, Leiter A. Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol. 2012;371:156-69 pubmed publisher
    Notch signaling inhibits differentiation of endocrine cells in the pancreas and intestine...
  3. Cho C, Hannan N, Docherty F, Docherty H, Joåo Lima M, Trotter M, et al. Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells. Diabetologia. 2012;55:3284-95 pubmed publisher
    ..However, developing methods to differentiate hESCs/hIPSCs into specific cell types following a natural pathway of development remains a major challenge...
  4. Comunoglu C, Altaca G, Demiralay E, Moray G. Multiple metastatic renal cell carcinoma isolated to pancreas. Malays J Pathol. 2012;34:63-6 pubmed
    Renal cell carcinoma (RCC) metastases to the pancreas are reported to be rare. Isolated multiple pancreatic metastases are even rarer...
  5. Jennings R, Berry A, Kirkwood Wilson R, Roberts N, Hearn T, Salisbury R, et al. Development of the human pancreas from foregut to endocrine commitment. Diabetes. 2013;62:3514-22 pubmed publisher
    Knowledge of human pancreas development underpins our interpretation and exploitation of human pluripotent stem cell (PSC) differentiation toward a ?-cell fate...
  6. Oury F, Ferron M, Huizhen W, Confavreux C, Xu L, LaCombe J, et al. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest. 2013;123:2421-33 pubmed
    ..This study uncovers the existence of a second endocrine axis that is necessary for optimal male fertility in the mouse and suggests that osteocalcin modulates reproductive function in humans...
  7. Kredo Russo S, Mandelbaum A, Ness A, Alon I, Lennox K, Behlke M, et al. Pancreas-enriched miRNA refines endocrine cell differentiation. Development. 2012;139:3021-31 pubmed publisher
    Genome-encoded microRNAs (miRNAs) provide a post-transcriptional regulatory layer that is important for pancreas development...
  8. Speer A, Barthel E, Patel M, Grikscheit T. Solid pseudopapillary tumor of the pancreas: a single-institution 20-year series of pediatric patients. J Pediatr Surg. 2012;47:1217-22 pubmed publisher
    Solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm. The objective of this study was to review our institution's experience and provide an update on current management in the pediatric population.
  9. Liu H, Shi J, Anandan V, Wang H, Diehl D, Blansfield J, et al. Reevaluation and identification of the best immunohistochemical panel (pVHL, Maspin, S100P, IMP-3) for ductal adenocarcinoma of the pancreas. Arch Pathol Lab Med. 2012;136:601-9 pubmed publisher
    Differentiation of ductal adenocarcinoma of the pancreas from nonneoplastic pancreatic tissues can be challenging, especially in small biopsy and fine-needle aspiration specimens.
  10. Huch M, Bonfanti P, Boj S, Sato T, Loomans C, van de Wetering M, et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J. 2013;32:2708-21 pubmed publisher
    ..Wnt signalling is inactive and Lgr5 is not expressed under physiological conditions in the adult pancreas. However, we now report that the Wnt pathway is robustly activated upon injury by partial duct ligation (PDL), ..
  11. Muhlbauer E, Bazwinsky Wutschke I, Wolgast S, Labucay K, Peschke E. Differential and day-time dependent expression of nuclear receptors ROR?, ROR?, ROR? and RXR? in the rodent pancreas and islet. Mol Cell Endocrinol. 2013;365:129-38 pubmed publisher
    ..expression of the orphan receptors ROR?, ROR? and ROR? and of the nuclear retinoid receptor RXR? in the pancreas and islet of rats. Immunohistochemistry of rodent islets detected nuclear receptor expression...
  12. Banakh I, Gonez L, Sutherland R, Naselli G, Harrison L. Adult pancreas side population cells expand after ? cell injury and are a source of insulin-secreting cells. PLoS ONE. 2012;7:e48977 pubmed publisher
    b>Pancreas stem cells are a potential source of insulin-producing ? cells for the therapy of diabetes...
  13. Mekuchi M, Watanabe S, Kaneko T. Bicarbonate secreted from the pancreas contributed to the formation of Ca precipitates in Japanese eel, Anguilla japonica. J Exp Zool A Ecol Genet Physiol. 2013;319:53-62 pubmed publisher
    ..It has been reported that HCO(3)(-) originates from the intestine; however, the pancreas is predicted to be another organ that may supply HCO(3)(-) to the intestinal tract...
  14. Manfroid I, Ghaye A, Naye F, Detry N, Palm S, Pan L, et al. Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev Biol. 2012;366:268-78 pubmed publisher
    ..Furthermore, beta cell recovery after specific ablation is severely compromised in sox9b mutant larvae. Our data position sox9b as a key player in the generation of secondary endocrine cells deriving from pancreatic ducts in zebrafish...
  15. Talchai C, Xuan S, Lin H, Sussel L, Accili D. Pancreatic ? cell dedifferentiation as a mechanism of diabetic ? cell failure. Cell. 2012;150:1223-34 pubmed publisher
    ..We propose that dedifferentiation trumps endocrine cell death in the natural history of ? cell failure and suggest that treatment of ? cell dysfunction should restore differentiation, rather than promoting ? cell replication...
  16. Badole S, Bagul P, Mahamuni S, Khose R, Joshi A, Jangam G, et al. Oral L-glutamine increases active GLP-1 (7-36) amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats. Chem Biol Interact. 2013;203:530-41 pubmed publisher
    ..L-glutamine decreased plasma glucose, increased plasma and pancreatic insulin, increased plasma and colonic active GLP-1 (7-36) amide secretion as well as decreased oxidative stress in streptozotocin-nicotinamide induced diabetic rats...
  17. Saisho Y, Butler A, Manesso E, Elashoff D, Rizza R, Butler P. ?-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care. 2013;36:111-7 pubmed publisher
    ..We sought to establish ?-cell mass, ?-cell apoptosis, and ?-cell replication in humans in response to obesity and advanced age...
  18. Andersson O, Adams B, Yoo D, Ellis G, Gut P, Anderson R, et al. Adenosine signaling promotes regeneration of pancreatic ? cells in vivo. Cell Metab. 2012;15:885-94 pubmed publisher
    ..With this whole-organism screen, we identified components of the adenosine pathway that could be therapeutically targeted for the treatment of diabetes...
  19. Vrang N, Jelsing J, Simonsen L, Jensen A, Thorup I, Søeborg H, et al. The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis. Am J Physiol Endocrinol Metab. 2012;303:E253-64 pubmed publisher
    ..and stereological (specific cell mass and proliferation rate) evaluation of the exocrine and the endocrine pancreas was performed...
  20. Weedon M, Cebola I, Patch A, Flanagan S, De Franco E, Caswell R, et al. Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet. 2014;46:61-64 pubmed publisher
    ..recessive mutations in a previously uncharacterized ~400-bp sequence located 25 kb downstream of PTF1A (encoding pancreas-specific transcription factor 1a) in ten families with pancreatic agenesis...
  21. Flanagan S, De Franco E, Lango Allen H, Zerah M, Abdul Rasoul M, Edge J, et al. Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man. Cell Metab. 2014;19:146-54 pubmed publisher
    ..and MNX1 are etiological genes for neonatal diabetes, thus confirming their key role in development of the human pancreas. The similar phenotype of the patients with recessive mutations and mice with inactivation of a transcription ..
  22. Butler A, Campbell Thompson M, Gurlo T, Dawson D, Atkinson M, Butler P. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes. 2013;62:2595-604 pubmed publisher
  23. Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, et al. Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc Natl Acad Sci U S A. 2013;110:4557-62 pubmed publisher
    ..We have recently generated functional pancreas and kidney from PSCs in pancreatogenesis- or nephrogenesis-disabled mice, providing proof of principle for ..
  24. Ahmed D, Sharma M, Mukerjee A, Ramteke P, Kumar V. Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation "Qurs Tabasheer" in streptozotocin induced diabetic rats. BMC Complement Altern Med. 2013;13:10 pubmed publisher
  25. Alexander L. Congenital pancreatic anomalies, variants, and conditions. Radiol Clin North Am. 2012;50:487-98 pubmed publisher
    ..Common mimics of masses are also covered...
  26. Lo B, Strasser G, Sagolla M, Austin C, Junttila M, Mellman I. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J Cell Biol. 2012;199:1117-30 pubmed publisher
    ..In pancreas, cystic structures developed rapidly after Lkb1 inhibition...
  27. Ferdek P, Gerasimenko J, Peng S, Tepikin A, Petersen O, Gerasimenko O. A novel role for Bcl-2 in regulation of cellular calcium extrusion. Curr Biol. 2012;22:1241-6 pubmed publisher
    ..Bcl-2 regulates PMCA function in pancreatic acinar cells and thereby influences cell fate...
  28. Saccomandi P, Schena E, Caponero M, Di Matteo F, Martino M, Pandolfi M, et al. Theoretical analysis and experimental evaluation of laser-induced interstitial thermotherapy in ex vivo porcine pancreas. IEEE Trans Biomed Eng. 2012;59:2958-64 pubmed
    Laser-induced interstitial thermotherapy (LITT) has been recently applied to pancreas in animal models for ablation purpose...
  29. Ardito C, Grüner B, Takeuchi K, Lubeseder Martellato C, Teichmann N, Mazur P, et al. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell. 2012;22:304-17 pubmed publisher
    ..However, PDA mouse models show that mutant Kras expression early in development gives rise to a normal pancreas, with tumors forming only after a long latency or pancreatitis induction...
  30. Demir I, Wang K, Tieftrunk E, Giese N, Xing B, Friess H, et al. Neuronal plasticity in chronic pancreatitis is mediated via the neurturin/GFR?2 axis. Am J Physiol Gastrointest Liver Physiol. 2012;303:G1017-28 pubmed publisher
    ..Expression of NRTN/GFR?2 was compared between normal human pancreas (NP) and CP tissues via immunohistochemistry, immunoblotting, and quantitative RT-PCR and correlated to abdominal ..
  31. Arda H, Benitez C, Kim S. Gene regulatory networks governing pancreas development. Dev Cell. 2013;25:5-13 pubmed publisher
    ..Here, we have compiled reference GRNs underlying pancreas development from data mining that integrates multiple approaches, including mutant analysis, lineage tracing, ..
  32. Griffin M, Abu El Haija M, Abu El Haija M, Rokhlina T, Uc A. Simplified and versatile method for isolation of high-quality RNA from pancreas. Biotechniques. 2012;52:332-4 pubmed publisher
    Isolation of high-quality RNA from pancreas is challenging because the organ contains large quantities of RNases and undergoes autolysis upon harvest. Here we present a simplified perfusion method of the pancreas using an RNase inhibitor...
  33. Cano D, Soria B, Martin F, Rojas A. Transcriptional control of mammalian pancreas organogenesis. Cell Mol Life Sci. 2014;71:2383-402 pubmed publisher
    The field of pancreas development has markedly expanded over the last decade, significantly advancing our understanding of the molecular mechanisms that control pancreas organogenesis...
  34. Luan Z, Ma X, Zhang H, Zhang C, Guo R. Protective effect of ethyl pyruvate on pancreas injury in rats with severe acute pancreatitis. J Surg Res. 2013;181:76-84 pubmed publisher
    ..In this study, we investigated the effect of ethyl pyruvate (EP) on pancreas injury in rats with severe acute pancreatitis (SAP) and its possible mechanism.
  35. Selvaraju R, Velikyan I, Johansson L, Wu Z, Todorov I, Shively J, et al. In vivo imaging of the glucagonlike peptide 1 receptor in the pancreas with 68Ga-labeled DO3A-exendin-4. J Nucl Med. 2013;54:1458-63 pubmed publisher
    ..In the present study, (68)Ga-labeled exendin-4 was evaluated for PET imaging and quantification of GLP-1R in the pancreas.
  36. Lysy P, Weir G, Bonner Weir S. Concise review: pancreas regeneration: recent advances and perspectives. Stem Cells Transl Med. 2012;1:150-9 pubmed publisher
    ..Inducing replication of the remaining ?-cells and new islet formation from progenitors within the pancreas (neogenesis) are the most direct ways to increase the ?-cell mass...
  37. de Back W, Zhou J, Brusch L. On the role of lateral stabilization during early patterning in the pancreas. J R Soc Interface. 2013;10:20120766 pubmed publisher
    ..cannot explain the scattered spatial distribution of endocrine cells and the cell-type ratio in the developing pancreas. Based on evidence from acinar-to-islet cell transdifferentiation in vitro, we propose that lateral stabilization,..
  38. Ioannou M, Serafimidis I, Arnés L, Sussel L, Singh S, Vasiliou V, et al. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol. 2013;374:153-63 pubmed publisher
    ..In a screen conducted for downstream Ngn3 target genes using ES derived pancreas progenitors we identified Aldh1b1, encoding a mitochondrial enzyme, as one of the genes strongly up regulated in ..
  39. Gao Y, Sartori D, Li C, Yu Q, Kushner J, Simon M, et al. PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol. 2012;32:5129-39 pubmed publisher
    ..development and was found to prevent onset of diabetes, suggesting that PERK may be dispensable in the adult pancreas. To definitively establish the functional role of PERK in adult pancreata, we generated mice harboring a ..
  40. Atiq M, Bhutani M, Ross W, Raju G, Gong Y, Tamm E, et al. Role of endoscopic ultrasonography in evaluation of metastatic lesions to the pancreas: a tertiary cancer center experience. Pancreas. 2013;42:516-23 pubmed publisher
    Metastatic lesions to the pancreas pose diagnostic challenges with regards to their differentiation from primary pancreatic cancer...
  41. De Franco E, Shaw Smith C, Flanagan S, Shepherd M, Hattersley A, Ellard S. GATA6 mutations cause a broad phenotypic spectrum of diabetes from pancreatic agenesis to adult-onset diabetes without exocrine insufficiency. Diabetes. 2013;62:993-7 pubmed publisher
    ..Heterozygous GATA6 mutations cause a wide spectrum of diabetes manifestations, ranging from pancreatic agenesis to adult-onset diabetes with subclinical or no exocrine insufficiency. ..
  42. Liou G, Döppler H, Necela B, Krishna M, Crawford H, Raimondo M, et al. Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-?B and MMPs. J Cell Biol. 2013;202:563-77 pubmed publisher
    ..Our results provide evidence that macrophages infiltrating the pancreas drive this transdifferentiation process...
  43. Moniri M, Sun X, Rayat J, Dai D, Ao Z, He Z, et al. TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells. Cancer Gene Ther. 2012;19:652-8 pubmed publisher
    ..This study was performed to characterize pancreas-derived MSCs and investigate the effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-..
  44. Jang J, Chung Y, Kang C, Choi S, Hwang H, Lee W. Two cases of portal annular pancreas. Korean J Gastroenterol. 2012;60:52-5 pubmed
    Portal annular pancreas is one of the pancreatic fusion anomalies in which the uncinate process of the pancreas extends to fuse with the dorsal pancreas by encircling the portal vein or superior mesenteric vein...
  45. Yu X, Tang H, Huang L, Yang Y, Tian B, Yu C. Exenatide-induced chronic damage of pancreatic tissue in rats. Pancreas. 2012;41:1235-40 pubmed publisher
    ..The study aimed to explore exenatide-induced damage of pancreatic tissue in rats...
  46. Carrasco M, Delgado I, Soria B, Martin F, Rojas A. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012;122:3504-15 pubmed publisher
    ..To investigate the roles of GATA4 and GATA6 in mouse pancreas organogenesis, we conditionally inactivated these genes within the pancreas...
  47. Cleaver O, Dor Y. Vascular instruction of pancreas development. Development. 2012;139:2833-43 pubmed publisher
    ..During the early stages of embryonic development, blood vessels are required for pancreas specification. Later, the vasculature constrains pancreas branching, differentiation and growth...
  48. Brook O, Gourtsoyianni S, Brook A, Siewert B, Kent T, Raptopoulos V. Split-bolus spectral multidetector CT of the pancreas: assessment of radiation dose and tumor conspicuity. Radiology. 2013;269:139-48 pubmed publisher
    ..To assess tumor conspicuity and radiation dose with a new multidetector computed tomography (CT) protocol for pancreatic imaging that combines spectral CT and split-bolus injection...
  49. Rae M, Grace C, Hogg K, Wilson L, McHaffie S, Ramaswamy S, et al. The pancreas is altered by in utero androgen exposure: implications for clinical conditions such as polycystic ovary syndrome (PCOS). PLoS ONE. 2013;8:e56263 pubmed publisher
    ..05). The fetal pancreas expressed androgen receptors in islets and genes involved in ?-cell development and function (PDX1, IGF1R, INSR ..
  50. Liu K, Qin C, WANG Z, Liu S, Cui X, Zhang D. Expression of tumor necrosis factor-alpha-induced protein 8 in pancreas tissues and its correlation with epithelial growth factor receptor levels. Asian Pac J Cancer Prev. 2012;13:847-50 pubmed
    ..The results showed stronger staining of TNFAIP8 protein in pancreatic cancer tissues compared with normal pancreas tissue...
  51. Campbell Thompson M, Wasserfall C, Kaddis J, Albanese O Neill A, Staeva T, Nierras C, et al. Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes. Diabetes Metab Res Rev. 2012;28:608-17 pubmed publisher
    ..These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis...
  52. Van de Casteele M, Leuckx G, Baeyens L, Cai Y, Yuchi Y, Coppens V, et al. Neurogenin 3+ cells contribute to ?-cell neogenesis and proliferation in injured adult mouse pancreas. Cell Death Dis. 2013;4:e523 pubmed publisher
    We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to ? cells ex vivo...
  53. Wilfinger A, Arkhipova V, Meyer D. Cell type and tissue specific function of islet genes in zebrafish pancreas development. Dev Biol. 2013;378:25-37 pubmed publisher
    Isl1 is a LIM homeobox transcription factor showing conserved expression in the developing and mature vertebrate pancreas. So far, functions of pancreatic Isl1 have mainly been studied in the mouse, where Isl1 has independent functions ..