animal hepatitis


Summary: INFLAMMATION of the LIVER in non-human animals.

Top Publications

  1. Fox J, Handt L, Sheppard B, Xu S, Dewhirst F, Motzel S, et al. Isolation of Helicobacter cinaedi from the colon, liver, and mesenteric lymph node of a rhesus monkey with chronic colitis and hepatitis. J Clin Microbiol. 2001;39:1580-5 pubmed
    ..This is the first observation of H. cinaedi associated with active hepatitis and colitis in a nonhuman primate. ..
  2. Fox J, Rogers A, Whary M, Taylor N, Xu S, Feng Y, et al. Helicobacter bilis-associated hepatitis in outbred mice. Comp Med. 2004;54:571-7 pubmed
    ..bilis-infected mice of group III seroconverted to H. bilis outer membrane antigen. Helicobacter bilis infection is associated with hepatitis in SW mice and can confound experimental results...
  3. Garcia A, Erdman S, Xu S, Feng Y, Rogers A, Schrenzel M, et al. Hepatobiliary inflammation, neoplasia, and argyrophilic bacteria in a ferret colony. Vet Pathol. 2002;39:173-9 pubmed
    ..The clustering of severe hepatic disease in these cohabitating ferroes suggests a possible infectious etiology. The role of Helicobacter species and other bacteria in hepatitis and/or neoplasia in ferrets requires further study. ..
  4. Fushimi S, Ogino T, Hara J, Takahata T, Wakabayashi H, Watanabe H, et al. Forced expression of suppressor of cytokine signaling 3 in T cells protects the development of concanavalin A-induced hepatitis in mice. Clin Immunol. 2009;133:437-46 pubmed publisher
    ..These results suggest that forced expression of SOCS3 in T cells prevents ConA-induced liver injury by inhibiting several phases of Th1 responses. ..
  5. Mandigers P, van den Ingh T, Spee B, Penning L, Bode P, Rothuizen J. Chronic hepatitis in Doberman pinschers. A review. Vet Q. 2004;26:98-106 pubmed
    ..Based on recent findings chronic hepatitis in Doberman pinschers is most likely to be a form of copper toxicosis. Although there are several indications that suggest autoimmunity as well, this still remains unclear. ..
  6. Zheng S, Wang P, Tsabary G, Chen Y. Critical roles of TRAIL in hepatic cell death and hepatic inflammation. J Clin Invest. 2004;113:58-64 pubmed
    ..Thus, TRAIL plays a crucial role in hepatic cell death and hepatic inflammation. ..
  7. Brownstein D, Gras L. Differential pathogenesis of lethal mousepox in congenic DBA/2 mice implicates natural killer cell receptor NKR-P1 in necrotizing hepatitis and the fifth component of complement in recruitment of circulating leukocytes to spleen. Am J Pathol. 1997;150:1407-20 pubmed
  8. Watanabe N, Ikeda H, Kume Y, Satoh Y, Kaneko M, Takai D, et al. Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis. Thromb Haemost. 2009;102:389-96 pubmed publisher
  9. Lever M, Nelson M, Stagg A, Beedham R, Simpson A. Experimental acute respiratory Burkholderia pseudomallei infection in BALB/c mice. Int J Exp Pathol. 2009;90:16-25 pubmed publisher
    ..These results suggest that the BALB/c mouse is highly susceptible to B. pseudomallei by the aerosol route and represents a relevant model system of acute human melioidosis...

More Information


  1. Lucka L, Sel S, Danker K, Horstkorte R, Reutter W. Carcinoembryonic antigen-related cell-cell adhesion molecule C-CAM is greatly increased in serum and urine of rats with liver diseases. FEBS Lett. 1998;438:37-40 pubmed
    ..A particularly high concentration was measured in the urine of rats suffering from GalN hepatitis. ..
  2. Angus K. Granulomatous hepatitis in tortoises. Vet Rec. 2005;157:328 pubmed
  3. Speeti M, Stahls A, Meri S, Westermarck E. Upregulation of major histocompatibility complex class II antigens in hepatocytes in Doberman hepatitis. Vet Immunol Immunopathol. 2003;96:1-12 pubmed
    ..Inappropriate MHC class II expression in hepatocytes and mononuclear cell infiltration are suggesting an autoimmune nature for chronic hepatitis in Dobermans. ..
  4. Meertens N, Bokhove C, van den Ingh T. Copper-associated chronic hepatitis and cirrhosis in a European Shorthair cat. Vet Pathol. 2005;42:97-100 pubmed
    ..No evidence for increased dietary or environmental copper could be found. This and the pattern of hepatic copper storage, the associated inflammation and fibrosis, strongly suggest a primary copper storage disorder. ..
  5. Grinder M, Krausman P. Morbidity-mortality factors and survival of an urban coyote population in Arizona. J Wildl Dis. 2001;37:312-7 pubmed
    ..Coyotes in Tucson appear to be exposed to the viral, bacterial, and parasitic infections common in many coyote populations, but humans are the major source of mortality. ..
  6. Yamamoto H, Watanabe T, Mizuno H, Endo K, Fukushige J, Hosokawa T, et al. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. Free Radic Res. 2001;34:69-80 pubmed
    ..Moreover, mitochondrial oxidative damage might be involved in the development of acute hepatitis in LEC rats...
  7. Oz H, Chen T, Neuman M. Methionine deficiency and hepatic injury in a dietary steatohepatitis model. Dig Dis Sci. 2008;53:767-76 pubmed
    ..These data support a pivotal role for methionine in the pathogenesis of the dietary model of Meth-choline-deficient (MCD) steatohepatitis (NASH). ..
  8. Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, et al. Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. Hepatology. 2008;47:1644-54 pubmed publisher
    ..These findings indicate that SOCS1 plays important negative roles in fulminant hepatitis and that forced expression of SOCS1 is therapeutic in preventing hepatitis. ..
  9. Watson P. Chronic hepatitis in dogs: a review of current understanding of the aetiology, progression, and treatment. Vet J. 2004;167:228-41 pubmed
    ..Even the histological description for canine chronic hepatitis has yet to be standardised. Much research remains to be done and this review suggests some potential areas for future investigation. ..
  10. Oliĭnyk B, Kandul S, Oliĭnyk O. [Role of splenin and its active factor in regulating liver monooxygenase system in experimental immunodeficiency and hepatosohepatitis]. Ukr Biokhim Zh (1999). 2001;73:95-9 pubmed
    ..Under the NFS action the effect in activity of the last is caused by the factor influence on the reparative processes in the liver. ..
  11. Sternak M, Khomich T, Jakubowski A, Szafarz M, Szczepanski W, Białas M, et al. Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse. Pharmacol Rep. 2010;62:483-93 pubmed
    ..This response may play a hepatoprotective role compatible with the PGI(2)-releasing properties of MNA. ..
  12. Tsuji H, Harada A, Mukaida N, Nakanuma Y, Bluethmann H, Kaneko S, et al. Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. Infect Immun. 1997;65:1892-8 pubmed
    ..These results suggest that TNFRp55 but not Fas was involved in P. acnes-induced granuloma formation as well as subsequent LPS-induced liver injury and that TNFRp55 and Fas independently induced apoptosis of hepatocytes in vivo. ..
  13. Hayashi M, Kuge T, Endoh D, Nakayama K, Arikawa J, Takazawa A, et al. Hepatic copper accumulation induces DNA strand breaks in the liver cells of Long-Evans Cinnamon strain rats. Biochem Biophys Res Commun. 2000;276:174-8 pubmed
    ..Thus, the copper accumulation in the liver of LEC rats induced DNA strand breaks, but accumulation of iron did not. ..
  14. Klein D, Arora U, Lichtmannegger J, Finckh M, Heinzmann U, Summer K. Tetrathiomolybdate in the treatment of acute hepatitis in an animal model for Wilson disease. J Hepatol. 2004;40:409-16 pubmed
    ..Here, we investigate the potential use of TTM in treating the acute hepatic copper toxicosis in Long-Evans Cinnamon (LEC) rats, an authentic model for Wilson disease...
  15. Bohr U, Selgrad M, Ochmann C, Backert S, Konig W, Fenske A, et al. Prevalence and spread of enterohepatic Helicobacter species in mice reared in a specific-pathogen-free animal facility. J Clin Microbiol. 2006;44:738-42 pubmed
    ..Moreover, there is a high prevalence of rather uncommon Helicobacter species that may be a consequence of the current routine procedures used for health screening of SPF mice. ..
  16. Blobner M, Kochs E, Fink H, Mayer B, Veihelmann A, Brill T, et al. Pharmacokinetics and pharmacodynamics of vecuronium in rats with systemic inflammatory response syndrome: treatment with NG-monomethyl-L-arginine. Anesthesiology. 1999;91:999-1005 pubmed
    ..Modulation of nitric oxide synthesis may be a strategy that can be used in the future to improve xenobiotic metabolism in sepsis. ..
  17. Fife K, Liu Y, Schmelzer K, Tsai H, Kim I, Morisseau C, et al. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J Pharmacol Exp Ther. 2008;327:707-15 pubmed publisher
    ..However, LPS did have significant effects on plasma eicosanoid levels and hepatic Ephx2 expression, suggesting that in vivo EET levels are modulated in response to an inflammatory signal. ..
  18. Zhang H, Taylor J, Luther D, Johnston J, Murray S, Wyatt J, et al. Antisense oligonucleotide inhibition of Bcl-xL and Bid expression in liver regulates responses in a mouse model of Fas-induced fulminant hepatitis. J Pharmacol Exp Ther. 2003;307:24-33 pubmed
    ..In addition, this is the first reported example demonstrating the ability of antisense inhibitors to reduce expression of multiple proteins in animals by simultaneous dosing. ..
  19. Gantzer M, Spitz E, Accard N, Rooke R. Constitutive expression of the adenovirus E3-14.7K protein does not prolong adenovirus vector DNA persistence but protects mice against lipopolysaccharide-induced acute hepatitis. Hum Gene Ther. 2002;13:921-33 pubmed
    ..These results open new applications for the E3-encoded 14.7K protein, which can be used to protect organs against inflammatory reactions and TNF-alpha-mediated apoptosis. ..
  20. Coombs D, MacWilliams P, Phillips L, Nelson K, Darien B. Cholangiohepatitis in a calf. Vet Rec. 2002;150:551-2 pubmed
  21. Hwang J, Wang C, Chou F, Tseng T, Hsieh Y, Hsu J, et al. Protective effect of baicalin on tert-butyl hydroperoxide-induced rat hepatotoxicity. Arch Toxicol. 2005;79:102-9 pubmed
    ..Based on the results described above, we speculate that baicalin may play a chemopreventive role via reducing oxidative stress in living systems. ..
  22. Stockhaus C, Van Den Ingh T, Rothuizen J, Teske E. A multistep approach in the cytologic evaluation of liver biopsy samples of dogs with hepatic diseases. Vet Pathol. 2004;41:461-70 pubmed
    ..In summary, the stepwise approach based on logistic regression presented in this study might be helpful in the objective cytologic diagnosis of hepatic diseases...
  23. Choudhury S, Zhang R, Frenkel K, Kawamori T, Chung F, Roy R. Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats. Cancer Res. 2003;63:7704-7 pubmed
  24. Sasaki H, Yoshida S, Kitahara T, Yoshioka T, Nakagawa H, Nakamura T, et al. Influence of disease stage on polyethylenimine-mediated plasmid DNA delivery in murine hepatitis. Int J Pharm. 2006;318:139-45 pubmed
    ..These results indicate the necessity of considering the timing and dose of gene therapy according to the disease stage. ..
  25. Yang Y, Huang D, Liu G, Zhong J, Du K, Li Y, et al. Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression. Toxicol Sci. 2005;85:727-34 pubmed
    ..EROD activities, CYP1A1 expression, and AhR mRNA expression in vitamin A + TCDD-treated mice were lower than those in TCDD-treated mice, indicating that supplementation of vitamin A might attenuate the liver damage caused by TCDD. ..
  26. Abram M, Schluter D, Vuckovic D, Waber B, Doric M, Deckert M. Effects of pregnancy-associated Listeria monocytogenes infection: necrotizing hepatitis due to impaired maternal immune response and significantly increased abortion rate. Virchows Arch. 2002;441:368-79 pubmed
    ..A weak transcription of anti-listerial cytokines in the placenta in the absence of a cellular immune response could not prevent the fatal outcome of pregnancy-associated listeriosis. ..
  27. Mignon A, Rouquet N, Fabre M, Martin S, Pages J, Dhainaut J, et al. LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med. 1999;159:1308-15 pubmed
    ..These results provide evidence that inhibitors of the ICE caspase family can prevent or even overcome the ongoing hepatic injury induced by TNF-alpha during sepsis, ischemia-reperfusion, or severe hepatitis. ..
  28. Tsuji H, Mukaida N, Harada A, Kaneko S, Matsushita E, Nakanuma Y, et al. Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production. J Immunol. 1999;162:1049-55 pubmed
    ..Thus, endogenously produced IFN-gamma is involved in the pathogenesis of this liver injury model by regulating Mphi infiltration and granuloma formation in the priming phase as well as cytokine production in the eliciting phase. ..
  29. Bonder C, Ajuebor M, Zbytnuik L, Kubes P, Swain M. Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. J Immunol. 2004;172:45-53 pubmed
    ..In summary, the present data support the concept that neutrophils play an important and previously unrecognized role in governing Con A-induced CD4+ T cell recruitment to the liver and the subsequent development of hepatitis. ..
  30. Ramljak D, Jones A, Diwan B, Perantoni A, Hochadel J, Anderson L. Epidermal growth factor and transforming growth factor-alpha-associated overexpression of cyclin D1, Cdk4, and c-Myc during hepatocarcinogenesis in Helicobacter hepaticus-infected A/JCr mice. Cancer Res. 1998;58:3590-7 pubmed
    ..hepaticus-associated liver tumors and may have relevance to human cancers associated with bacterial, viral, or parasitic infections. ..
  31. Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, Ito D, et al. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity. 2004;21:539-50 pubmed
    ..These findings identify NKT cell-derived OPN as a novel target for the treatment of inflammatory liver diseases. ..
  32. Akanbi O, Breithaupt A, Polster U, Alter T, Quandt A, Bracke A, et al. Systemic listeriosis in caged canaries (Serinus canarius). Avian Pathol. 2008;37:329-32 pubmed publisher
    ..monocytogenes serotype 1/2a as the causative agent. Thus listeriosis has to be considered in the differential diagnosis for granulomas associated with mycobacteriosis, yersiniosis, coligranulomatosis or fungal infections. ..
  33. Sun Y, Qin Y, Gong F, Wu X, Hua Z, Chen T, et al. Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice. Biochem Pharmacol. 2009;77:1717-24 pubmed publisher
    ..These results strongly suggest fraxinellone might be a potential leading compound useful in treating T-cell-mediated liver disorders in humans. ..
  34. Zanin Zhorov A, Bruck R, Tal G, Oren S, Aeed H, Hershkoviz R, et al. Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines. J Immunol. 2005;174:3227-36 pubmed
    ..These results provide a molecular explanation for the effects of HSP60 treatment on T cell inflammation via innate regulation of the inflammatory response. ..
  35. Chakass D, Philippe D, Erdual E, Dharancy S, Malapel M, Dubuquoy C, et al. micro-Opioid receptor activation prevents acute hepatic inflammation and cell death. Gut. 2007;56:974-81 pubmed
    ..The results indicate that MOR agonists may prevent acute hepatitis and hold promising therapeutic use to maintain remission in both chronic inflammatory bowel and liver diseases. ..
  36. El Assal O, Hong F, Kim W, Radaeva S, Gao B. IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver. Cell Mol Immunol. 2004;1:205-11 pubmed
  37. Nishimura T, Ohta A. A critical role for antigen-specific Th1 cells in acute liver injury in mice. J Immunol. 1999;162:6503-9 pubmed
    ..The Fas/Fas ligand independency was also demonstrated using Fas-deficient lpr mice. These findings indicate that Th1 cells are the major effector cells in acute liver injury. ..
  38. Fong R, Gonzalez B, Fuentealba I, Cherian M. Role of tumor necrosis factor-alpha in the development of spontaneous hepatic toxicity in Long-Evans Cinnamon rats. Toxicol Appl Pharmacol. 2004;200:121-30 pubmed
    ..Thus, these results suggest a major role for TNF-alpha on the pathogenesis of Cu-induced acute hepatitis in LEC rats...
  39. Lavon I, Sheinin T, Meilin S, Biton E, Weksler A, Efroni G, et al. A novel synthetic cannabinoid derivative inhibits inflammatory liver damage via negative cytokine regulation. Mol Pharmacol. 2003;64:1334-41 pubmed
    ..These findings suggest that this cannabinoid derivative is an immunomodulator that could be developed as a potential drug for hepatitis as well as for other short- or long-term inflammatory diseases. ..
  40. Wong K, Maser R, Sahin E, Bailey S, Xia H, Ji H, et al. Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres. Oncogene. 2007;26:2815-21 pubmed
    ..These results raise speculation that these genetic factors may contribute to misdirected immune responses of the aged under conditions of acute and chronic stress. ..
  41. Johns I, del Piero F, Wilkins P. Hepatic encephalopathy in a pregnant mare: identification of histopathological changes in the brain of a mare and fetus. Aust Vet J. 2007;85:337-40 pubmed
    ..Pathological changes consistent with hepatic encephalopathy, (Alzheimer type II cells), were evident in the cerebrum of both the mare and the fetus. ..
  42. Gupta S, Rogler C. Lessons From Genetically Engineered Animal Models VI. Liver repopulation systems and study of pathophysiological mechanisms in animals. Am J Physiol. 1999;277:G1097-102 pubmed
    ..Transplanted hepatocytes are susceptible to hepatitis viruses. These aspects of transplanted hepatocyte biology indicate that liver repopulation systems can help address questions concerning pathophysiological mechanisms. ..
  43. Klein D, Lichtmannegger J, Heinzmann U, Summer K. Dissolution of copper-rich granules in hepatic lysosomes by D-penicillamine prevents the development of fulminant hepatitis in Long-Evans cinnamon rats. J Hepatol. 2000;32:193-201 pubmed
    ..However, the mobilization of copper by D-penicillamine seems to be limited due to the binding of the metal to metallothionein in liver cytosol. This copper, even at relatively high concentrations, apparently may be well tolerated. ..
  44. Chang B, Nishikawa M, Sato E, Inoue M. Mice lacking inducible nitric oxide synthase show strong resistance to anti-Fas antibody-induced fulminant hepatitis. Arch Biochem Biophys. 2003;411:63-72 pubmed
    ..In conclusion, these observations suggest that regulation of NO metabolism may have therapeutic potential in the treatment of patients with fulminant hepatitis. ..
  45. Suzuki K, Nakayama H, Doi K. Giant cell hepatitis in two young cats. J Vet Med Sci. 2001;63:199-201 pubmed
    ..Histopathological features of this liver lesion were very similar to giant cell hepatitis (GCH) in human neonates and infants. Therefore, the lesion was diagnosed as feline GCH. ..
  46. Chen F, Zhu H, Zhou L, Li J, Zhao L, Wu S, et al. Genes related to the very early stage of ConA-induced fulminant hepatitis: a gene-chip-based study in a mouse model. BMC Genomics. 2010;11:240 pubmed publisher
    ..These genes form a network and have shown strong correlation with fulminant hepatitis development. Our study provides several potential targets for the early diagnosis of fulminant hepatitis. ..
  47. Rasmussen M, Lauritsen L, Andersen L. [Role of Helicobacter species in hepatobiliary diseases]. Ugeskr Laeger. 2008;170:2010-5 pubmed
    ..The same trend was not found in studies of humans with other hepatobiliary diseases. There is no evidence of the possible involvement of Helicobacter species in the development of diseases in the hepatobiliary system. ..
  48. Ono T, Fukumoto R, Kondoh Y, Yoshida M. Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats. Jpn J Genet. 1995;70:25-33 pubmed
    ..The WD gene was assigned to rat chromosome 16 at band q12.2-q12.4 by fluorescence in situ hybridization (FISH). ..
  49. Haller B, Barkon M, Vogler G, Virgin H. Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes. J Virol. 1995;69:357-64 pubmed
    ..Organs (the brain and intestines versus the liver) differ in properties that determine which virulence genes, and thus which parts of this structural unit, are important. ..
  50. Huang S, Chisari F. Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology. 1995;21:620-6 pubmed
    ..The findings support the concept that sustained hepatocellular proliferation plays an important role in the development of hepatocellular carcinoma (HCC). ..
  51. Kang H, Kim Y, Sohn S, Baek S, Lee J, Kim S, et al. Pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats with acute hepatitis induced by d-galactosamine/lipopolysaccharide or CCl(4). Xenobiotica. 2010;40:424-36 pubmed publisher
    ..Modification of oral dosage regimen of LQ may not be necessary in patients with acute hepatitis; but human studies are required. ..
  52. Xu Y, Feng D, Wang Y, Lin S, Xu L. Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways. J Clin Immunol. 2008;28:512-9 pubmed publisher
  53. Tiegs G, Bang R, Neuhuber W. Requirement of peptidergic sensory innervation for disease activity in murine models of immune hepatitis and protection by beta-adrenergic stimulation. J Neuroimmunol. 1999;96:131-43 pubmed
    ..Hence, strategies reducing the activity of peptidergic sensory nerve fibres or stimulating beta2-adrenoreceptors, may be of benefit in immune-mediated liver disease. ..