Research Topics

Genomes and Genes

animal hepatitis

Summary

Summary: INFLAMMATION of the LIVER in non-human animals.

Publications

  1. Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice
    Mei Gao
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Liver Int 25:904-12
  2. Development of anorexia in concanavalin A-induced hepatitis in mice
    T Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, 1-22 Hikokawato, Misato, Saitama 341-0005, Japan
    Int J Mol Med 7:169-72
  3. NOD2: a potential target for regulating liver injury
    Mathilde Body Malapel
    INSERM U795, Lille, France
    Lab Invest 88:318-27
  4. IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1
    Barbara Jaruga
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1044-52
  5. Critical contribution of liver natural killer T cells to a murine model of hepatitis
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 97:5498-503
  6. Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells
    Yunhua Mei
    Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Immunol Lett 110:29-35
  7. Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis
    Takehiro Torisu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Hepatology 47:1644-54
  8. Antinecrotic and antiapoptotic effects of hepatocyte growth factor on cholestatic hepatitis in a mouse model of bile-obstructive diseases
    Zhaodong Li
    Division of Molecular Regenerative Medicine, Dept of Biochemistry and Molecular Biology, Osaka Univ Graduate School of Medicine, Yamadaoka 2 2 B7, Suita, Osaka, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G639-46
  9. Mechanism of protective action of bicyclol against CCl-induced liver injury in mice
    Geng Tao Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Liver Int 25:872-9
  10. Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production
    H Tsuji
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Immunol 162:1049-55

Scientific Experts

Detail Information

Publications62

  1. Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice
    Mei Gao
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Liver Int 25:904-12
    ..These results suggest that DDB could directly protect hepatocyte DNA from oxidative damage, and inhibit TNF-alpha mRNA expression in liver tissue, which resulted in prevention of liver damage induced by Con A in mice...
  2. Development of anorexia in concanavalin A-induced hepatitis in mice
    T Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, 1-22 Hikokawato, Misato, Saitama 341-0005, Japan
    Int J Mol Med 7:169-72
    ..The present results indicate that treatment of mice with concanavalin A caused the development of anorexia and that this anorexia might develop independently of the induction of hepatitis...
  3. NOD2: a potential target for regulating liver injury
    Mathilde Body Malapel
    INSERM U795, Lille, France
    Lab Invest 88:318-27
    ..Taken together, our results indicate that NOD2 may represent a new therapeutic target in liver diseases...
  4. IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1
    Barbara Jaruga
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1044-52
    ....
  5. Critical contribution of liver natural killer T cells to a murine model of hepatitis
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 97:5498-503
    ..These results implicated FasL expression on liver NKT cells in the pathogenesis of Con A-induced hepatitis, suggesting a similar pathogenic role in human liver diseases such as autoimmune hepatitis...
  6. Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells
    Yunhua Mei
    Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Immunol Lett 110:29-35
    ..Such CIH-suppression is dose- and frequency-dependent. The suppressive effect was associated with inhibition of several major inflammatory mediators, pro-inflammatory cytokines and chemokines...
  7. Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis
    Takehiro Torisu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Hepatology 47:1644-54
    ..Conclusion: These findings indicate that SOCS1 plays important negative roles in fulminant hepatitis and that forced expression of SOCS1 is therapeutic in preventing hepatitis...
  8. Antinecrotic and antiapoptotic effects of hepatocyte growth factor on cholestatic hepatitis in a mouse model of bile-obstructive diseases
    Zhaodong Li
    Division of Molecular Regenerative Medicine, Dept of Biochemistry and Molecular Biology, Osaka Univ Graduate School of Medicine, Yamadaoka 2 2 B7, Suita, Osaka, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G639-46
    ....
  9. Mechanism of protective action of bicyclol against CCl-induced liver injury in mice
    Geng Tao Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Liver Int 25:872-9
    ..These results suggest that bicyclol has remarkable hepatoprotective effects and its mechanism of action may be related to a decrease in free radical-induced damage to hepatocytes...
  10. Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production
    H Tsuji
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Immunol 162:1049-55
    ..Thus, endogenously produced IFN-gamma is involved in the pathogenesis of this liver injury model by regulating Mphi infiltration and granuloma formation in the priming phase as well as cytokine production in the eliciting phase...
  11. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes
    Barbara Jaruga
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 171:3233-44
    ....
  12. CD44-deficient mice exhibit enhanced hepatitis after concanavalin A injection: evidence for involvement of CD44 in activation-induced cell death
    D Chen
    Departments of Microbiology and Immunology and Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 166:5889-97
    ..Together, these data demonstrate that activated T cells use CD44 to undergo apoptosis, and dysregulation in this pathway could lead to increased pathogenesis in a number of diseases, including hepatitis...
  13. Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes
    Y Tagawa
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 159:1418-28
    ..These observations suggest that IFN-gamma plays a central role in Con A-hepatitis by activating Fas-induced apoptosis of liver cells...
  14. A monoclonal antibody to the alpha2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model
    Shuji Matsuoka
    Department of Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
    J Exp Med 198:497-503
    ....
  15. Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model
    Kazue Sasaki
    Medicinal Chemistry Research Laboratory, Pharmaceutical Research Department, Meiji Seika Kaisha, Ltd, 760 Morooka-cho, Yokohama 222-8567, Japan
    Bioorg Med Chem 13:4900-11
    ..Among the series of soyasapogenol B derivatives examined, six compounds exhibited preventive effects on liver damage...
  16. [Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage]
    M Bilzer
    Medizinische Klinik II, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München
    Z Gastroenterol 40:543-4
  17. Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice
    Keishi Adachi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 16:787-98
    ..berghei-induced liver injury. Our studies may have general implications for tissue injuries that are caused by 'bystander killing' or other poorly defined cell-mediated killing mechanisms...
  18. Enhanced inducible nitric oxide synthase expression and nitrotyrosine accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice
    C-K Fan
    Department of Parasitology, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    Parasite Immunol 26:273-81
    ..593, P = 0.021) in the trial. Our present results indicate a potential therapeutic strategy for treatment of GH caused by other nematodes through manipulation of iNOS expression...
  19. Enhanced expression of transforming growth factor-beta 1 in inflammatory cells, alpha-smooth muscle actin in stellate cells, and collagen accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice
    Ming Shun Wu
    Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Acta Trop 105:260-8
    ....
  20. IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver
    Osama El-Assal
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 1:205-11
    ....
  21. Mice lacking inducible nitric oxide synthase show strong resistance to anti-Fas antibody-induced fulminant hepatitis
    BaoJun Chang
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno, 545-8585, Osaka, Japan
    Arch Biochem Biophys 411:63-72
    ..In conclusion, these observations suggest that regulation of NO metabolism may have therapeutic potential in the treatment of patients with fulminant hepatitis...
  22. Efficacy of zinc supplementation in preventing acute hepatitis in Long-Evans Cinnamon rats
    Valentina Medici
    Section of Gastroenterology, Department of Surgical and Gastroenterological Sciences, University of Padova, Italy
    Liver Int 25:888-95
    ..8-hydroxy-2'-deoxyguanosine amounts were significantly lower in untreated rats. CONCLUSIONS: Zn acetate prevents acute hepatitis, by increasing tissue MT concentrations, reducing Cu absorption and interfering with Fe metabolism...
  23. Chronic hepatitis associated with canine leishmaniosis (Leishmania infantum): a clinicopathological study of 26 cases
    T Rallis
    Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki, Stavrou Voutyra 11, GR-54627, Thessaloniki, Greece
    J Comp Pathol 132:145-52
    ....
  24. Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis
    Claudine S Bonder
    Immunology Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Immunol 172:45-53
    ..In summary, the present data support the concept that neutrophils play an important and previously unrecognized role in governing Con A-induced CD4+ T cell recruitment to the liver and the subsequent development of hepatitis...
  25. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases
    Hongyan Diao
    Division of Molecular Immunology, Hokkaido University, Sapporo 060 0815, Japan
    Immunity 21:539-50
    ..These findings identify NKT cell-derived OPN as a novel target for the treatment of inflammatory liver diseases...
  26. Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways
    Yan Xu
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, People s Republic of China
    J Clin Immunol 28:512-9
    ....
  27. Modulation of intracellular machinery by beta-glycolipids is associated with alteration of NKT lipid rafts and amelioration of concanavalin-induced hepatitis
    Gadi Lalazar
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Mol Immunol 45:3517-25
    ....
  28. Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model
    Yoshihiro Kamada
    Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, K1, Yamada oka, Suita, Osaka 565 0871, Japan
    J Hepatol 47:556-64
    ..Hypoadiponectinemia in obesity could be a risk factor for NASH-related hepatic tumor formation...
  29. Chronic hepatitis in Doberman pinschers. A review
    P J J Mandigers
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Vet Q 26:98-106
    ..Based on recent findings chronic hepatitis in Doberman pinschers is most likely to be a form of copper toxicosis. Although there are several indications that suggest autoimmunity as well, this still remains unclear...
  30. Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis
    Jun Yu
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Gut 56:991-9
    ..Inhibition of COX-2 represents a mechanism-based chemopreventive approach to hepatitis...
  31. Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis
    Xiaoxing Xiang
    Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Chin Med J (Engl) 115:593-6
    ....
  32. Influence of disease stage on polyethylenimine-mediated plasmid DNA delivery in murine hepatitis
    Hitoshi Sasaki
    Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Pharm 318:139-45
    ..These results indicate the necessity of considering the timing and dose of gene therapy according to the disease stage...
  33. Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine
    Raghubir P Sharma
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Toxicology 216:59-71
    ....
  34. Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice
    Vanessa M Silva
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269 3092, USA
    Toxicol Lett 160:204-11
    ....
  35. Protective effect of baicalin on tert-butyl hydroperoxide-induced rat hepatotoxicity
    Jin-Ming Hwang
    Department of Biochemistry, Medical College, Chung Shan Medical University, No. 110, Section 1, Chien Kuo N. Rd, 402 Taichung, Taiwan
    Arch Toxicol 79:102-9
    ..Based on the results described above, we speculate that baicalin may play a chemopreventive role via reducing oxidative stress in living systems...
  36. Inhibitory effects of vitamin A on TCDD-induced cytochrome P-450 1A1 enzyme activity and expression
    Yan-Mei Yang
    Molecular Biology Center, Shantou University Medical College, Shantou, Guangdong 515041, People's Republic of China
    Toxicol Sci 85:727-34
    ..EROD activities, CYP1A1 expression, and AhR mRNA expression in vitamin A + TCDD-treated mice were lower than those in TCDD-treated mice, indicating that supplementation of vitamin A might attenuate the liver damage caused by TCDD...
  37. Melatonin-selenium nanoparticles protects liver against immunological injury induced by bacillus Calmette-Guerin and lipopolysaccharide
    Hua Wang
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China
    Acta Pharmacol Sin 26:745-52
    ..A downregulation effect of MT-Se on splenocyte proliferation was also observed. CONCLUSION: MT-Se showed a hepatic protective action on immunological liver injury in mice...
  38. Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives
    T Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, 1-22 Hikokawato, Misato, Saitama 341-0005, Japan
    Int J Mol Med 7:177-80
    ..The present results showed the inhibition of anti-Fas antibody-induced hepatitis by imperatorin and Y355, which might be a result of inhibition of caspase activities...
  39. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism
    K Adachi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Science, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Immunol 167:5928-34
    ..berghei infection of mice induces activation of the TLR-MyD88 signaling pathway which results in IL-12 production and activation of the perforin-dependent cytotoxic activities of MHC-unrestricted hepatic lymphocytes...
  40. Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviral cytotoxic T cell responses
    B Ludewig
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    J Immunol 166:3369-76
    ..These findings impinge on our understanding of hypercholesterolemia as a disease parameter and may explain aspects of the frequent association of persistent pathogens with hypercholesterolemia-induced diseases, such as atherosclerosis...
  41. Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis
    J D Gorham
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 166:6413-22
    ..This represents the first murine model of hepatitis that develops spontaneously, is restricted by genetic background, and is dependent upon the Th1 cytokine IFN-gamma, and that thus recapitulates these important aspects of AIH...
  42. Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation
    Rinke Stienstra
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    Endocrinology 148:2753-63
    ....
  43. Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody
    P Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Italy
    Cell Death Differ 10:997-1004
    ..The precise cellular and molecular details underlying this interplay between Fas- and TNFRs-mediated signaling systems in the general and liver-specific aFas toxicity largely remain to be clarified...
  44. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes
    Haidong Dong
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Immunity 20:327-36
    ..Therefore, B7-H1 is a key protein selectively regulating the accumulation and deletion of intrahepatic CD8(+) T cells and may also contribute to inflammation, autoimmune diseases, and tolerance in the liver...
  45. TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax
    Gabriele Sass
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 179:7042-9
    ....
  46. Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene
    Yan Meng
    Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Biochim Biophys Acta 1690:208-19
    ..This first successful transgenic rescue has important implications for the gene therapy of WD...
  47. Tetrathiomolybdate in the treatment of acute hepatitis in an animal model for Wilson disease
    Dominik Klein
    Institute of Toxicology and Environmental Hygiene, Technical University Munich, Germany
    J Hepatol 40:409-16
    ..As a consequence, metallothionein is degraded and the uptake of copper-metallothionein into the lysosomes and the formation of the metallothionein polymer associated copper is reduced...
  48. [Gene expressions of LTC4 synthase homologs in Con A-induced mouse hepatitis and regulative effect of cyclosporine A]
    Luo Yang Qi
    Institute of Pharmacology and Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:241-6
    ..Cs A pretreatment results in protection of liver damage, whereas fails to fully inhibit the increase of mGST2 gene expression...
  49. IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners
    Rui Sun
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:5648-55
    ..Taken together, these findings suggest that in addition to its antiapoptotic abilities, as previously well documented, IL-6/STAT3 inhibits NKT cells via targeting CD4(+) T cells and consequently prevents T cell-mediated hepatitis...
  50. Association between liver copper concentration and subclinical hepatitis in Doberman Pinschers
    P J J Mandigers
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    J Vet Intern Med 18:647-50
    ..The results of this study suggest that there is a relationship among copper storage, hepatocellular damage, and hepatitis in Doberman Pinschers...
  51. A multistep approach in the cytologic evaluation of liver biopsy samples of dogs with hepatic diseases
    C Stockhaus
    Department of Small Animals, University of Leipzig, Germany
    Vet Pathol 41:461-70
    ..In summary, the stepwise approach based on logistic regression presented in this study might be helpful in the objective cytologic diagnosis of hepatic diseases...
  52. Double-blind, placebo-controlled study of the efficacy of nandrolone laurate in the treatment of dobermanns with subclinical hepatitis
    P J J Mandigers
    Department of Clinical Sciences of Companion Animals, PO Box 80154, University of Utrecht, 3508 TD Utrecht, The Netherlands
    Vet Rec 157:313
    ....
  53. Hepatitis with special reference to dogs. A review on the pathogenesis and infectious etiologies, including unpublished results of recent own studies
    S Y Boomkens
    Department of Clinical Sciences of Companian Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Vet Q 26:107-14
    ....
  54. Improvement in liver pathology after 4 months of D-penicillamine in 5 doberman pinschers with subclinical hepatitis
    P J J Mandigers
    Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    J Vet Intern Med 19:40-3
    ..However, because D-penicillamine has both copper-chelating and anti-inflammatory properties, it is not possible to draw conclusions on the etiology of this disease...
  55. Diagnosis of chronic active hepatitis in a miniature schnauzer
    Alana D Hendrix
    Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon
    Can Vet J 45:765-7
    ..A wedge biopsy provided a diagnosis of chronic active hepatitis. A therapeutic regime was initiated to improve the quality of life and slow the progression of this disease is described...
  56. Hepatic (64)Cu excretion in Dobermanns with subclinical hepatitis
    Paul J J Mandigers
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University Utrecht, Yalelaan 108, 3584 CM Utrecht, The Netherlands
    Res Vet Sci 83:204-9
    ..The findings suggest that impaired copper excretion may play a role in the aetiology of chronic hepatitis in the Dobermann...
  57. Fumonisin B1 hepatotoxicity in mice is attenuated by depletion of Kupffer cells by gadolinium chloride
    Quanren He
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602-7389, USA
    Toxicology 207:137-47
    ..Decreased FB1-induced sphinganine accumulation and increased protective TNFalpha signaling by gadolinium chloride may in part account for its ameliorating effect on FB1 liver damage...
  58. Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses
    D W Hartwell
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 143:1129-41
    ..Our results suggest that different sorting mechanisms for P-selectin are used in platelets and endothelial cells and that the storage pool of P-selectin in endothelial cells is functionally important during early stages of inflammation...
  59. Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system
    Hongyan Dong
    Department of Molecular Preventive Medicine and CREST, School of Medicine, The University of Tokyo, Japan
    Biochem Biophys Res Commun 298:675-86
    ..Taken together this study has shown the systemic and comprehensive gene expression profile during FHF and may contribute to better understanding of the mechanism of FHF...
  60. Loss of immunogenecity of liver dendritic cells from mouse with chronic hepatitis
    Masanori Abe
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Toshima-ku, Tokyo 170-8455, Japan
    Int J Mol Med 9:71-6
    ..Defective capacity of liver DC from mouse with chronic hepatitis (IFN-gamma TgM) may be related to impaired magnitude of specific immune response in the liver...
  61. Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis
    H Tsuji
    Department of Pharmacology, Cancer Research Institute, Kanazawa University, Takara machi, Japan
    Infect Immun 65:1892-8
    ..These results suggest that TNFRp55 but not Fas was involved in P. acnes-induced granuloma formation as well as subsequent LPS-induced liver injury and that TNFRp55 and Fas independently induced apoptosis of hepatocytes in vivo...