liver

Summary

Summary: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

Top Publications

  1. von Wilamowitz Moellendorff A, Hunter R, García Rocha M, Kang L, López Soldado I, Lantier L, et al. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes. 2013;62:4070-82 pubmed publisher
    The liver responds to an increase in blood glucose levels in the postprandial state by uptake of glucose and conversion to glycogen...
  2. Fomin M, Zhou Y, Beyer A, Publicover J, Baron J, Muench M. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS ONE. 2013;8:e77255 pubmed publisher
    b>Liver sinusoidal endothelial cells (LSECs) form a semi-permeable barrier between parenchymal hepatocytes and the blood...
  3. Lanaspa M, Ishimoto T, Li N, Cicerchi C, Orlicky D, Ruzycki P, et al. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434 pubmed publisher
    ..with high glycaemic index are proposed to promote the development of obesity, insulin resistance and fatty liver, but the mechanism by which this occurs remains unknown...
  4. Vorrink S, Severson P, Kulak M, Futscher B, Domann F. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol. 2014;274:408-16 pubmed publisher
    ..Elucidation of this interaction is important in liver hepatocytes which extensively metabolize ingested PCBs and experience varying degrees of oxygen tension during ..
  5. Kroy D, Ciuffreda D, Cooperrider J, Tomlinson M, Hauck G, Aneja J, et al. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology. 2014;146:550-61 pubmed publisher
    ..between T-cell location, expression of inhibitory receptors, maturation, and viral control using blood and liver T cells from patients with hepatitis C virus (HCV) and other viral infections...
  6. Lambert J, Ramos Román M, Browning J, Parks E. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology. 2014;146:726-35 pubmed publisher
    There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD)...
  7. Liu S, Roberts D, Zhang B, Ren Y, Zhang L, Wu Y. Trefoil factor 3 as an endocrine neuroprotective factor from the liver in experimental cerebral ischemia/reperfusion injury. PLoS ONE. 2013;8:e77732 pubmed publisher
    ..Partial hepatectomy (~60% liver resection) immediately following cerebral injury significantly lowered the serum level of TFF3, suggesting a ..
  8. Uesugi M, Hosokawa M, Shinke H, Hashimoto E, Takahashi T, Kawai T, et al. Influence of cytochrome P450 (CYP) 3A4*1G polymorphism on the pharmacokinetics of tacrolimus, probability of acute cellular rejection, and mRNA expression level of CYP3A5 rather than CYP3A4 in living-donor liver transplant patients. Biol Pharm Bull. 2013;36:1814-21 pubmed
    ..the pharmacokinetics of tacrolimus and the risk of acute cellular rejection was examined in Japanese living-donor liver transplant patients between 2004 and 2011...
  9. Koch M, Borggrefe J, Barbaresko J, Groth G, Jacobs G, Siegert S, et al. Dietary patterns associated with magnetic resonance imaging-determined liver fat content in a general population study. Am J Clin Nutr. 2014;99:369-77 pubmed publisher
    The association between diet and fatty liver disease (FLD) has predominantly been analyzed for single nutrients or foods, and findings have been inconsistent...

More Information

Publications97

  1. Barcelos R, Souza M, Amaral G, Stefanello S, Bresciani G, Fighera M, et al. Caffeine supplementation modulates oxidative stress markers in the liver of trained rats. Life Sci. 2014;96:40-5 pubmed publisher
    ..the studies regarding caffeine and exercise have focused on muscle and plasma adaptations, while the impact on the liver is scarcely described...
  2. Schussek S, Groves P, Apte S, Doolan D. Highly sensitive quantitative real-time PCR for the detection of Plasmodium liver-stage parasite burden following low-dose sporozoite challenge. PLoS ONE. 2013;8:e77811 pubmed publisher
    ..efforts in the last decade have been focused on in vitro culture and in vivo detection and quantification of liver stage parasites to assess the effects of candidate vaccines or drugs...
  3. Leite M, Freitas A, Azul A, Barbosa J, Costa S, Ramos F. Development, optimization and application of an analytical methodology by ultra performance liquid chromatography-tandem mass spectrometry for determination of amanitins in urine and liver samples. Anal Chim Acta. 2013;799:77-87 pubmed publisher
    ..methodology by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), following urine and liver sample preparation by protein precipitation with organic solvents, and solid phase extraction (SPE) procedure, for ..
  4. Mauvoisin D, Wang J, Jouffe C, Martin E, Atger F, Waridel P, et al. Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver. Proc Natl Acad Sci U S A. 2014;111:167-72 pubmed publisher
    ..Also, these rhythms persisted in clock-deficient animals subjected to rhythmic feeding, suggesting that food-related entrainment signals influence rhythms in circulating plasma factors. ..
  5. Frevert U, Nacer A, Cabrera M, Movila A, Leberl M. Imaging Plasmodium immunobiology in the liver, brain, and lung. Parasitol Int. 2014;63:171-86 pubmed publisher
    ..Due to extremely low parasite densities, the liver was considered a black box in terms of Plasmodium sporozoite invasion, liver stage development, and merozoite ..
  6. Lamming D, Demirkan G, Boylan J, Mihaylova M, Peng T, Ferreira J, et al. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J. 2014;28:300-15 pubmed publisher
    ..In mice in which the mTORC2 component Rictor is deleted in liver [Rictor-knockout (RKO) mice], we used genomic and phosphoproteomic analyses to characterize the role of hepatic ..
  7. Lisowski L, Dane A, Chu K, Zhang Y, Cunningham S, Wilson E, et al. Selection and evaluation of clinically relevant AAV variants in a xenograft liver model. Nature. 2014;506:382-6 pubmed publisher
    ..Here, in an attempt to further our understanding of these discrepancies, we used a chimaeric human-murine liver model to compare directly the relative efficiency of rAAV transduction in human versus mouse hepatocytes in vivo...
  8. Zhang Q, Fu H, Zhang H, Xu F, Zou Z, Liu M, et al. Hydrogen sulfide preconditioning protects rat liver against ischemia/reperfusion injury by activating Akt-GSK-3? signaling and inhibiting mitochondrial permeability transition. PLoS ONE. 2013;8:e74422 pubmed publisher
    ..To establish a model of segmental (70%) warm hepatic ischemia, the hepatic artery, left portal vein and median liver lobes were occluded for 60 min and then unclamped to allow reperfusion. Preconditioning with 12...
  9. Ruiz R, Jideonwo V, Ahn M, Surendran S, Tagliabracci V, Hou Y, et al. Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J Biol Chem. 2014;289:5510-7 pubmed publisher
    ..In conclusion, silencing both isoforms of SREBP-1 leads to significant changes in carbohydrate metabolism and does not improve insulin resistance despite reducing steatosis in an animal model of obesity and type 2 diabetes. ..
  10. Takahashi M, Yamada N, Hatakeyama H, Murata M, Sato Y, Minakawa N, et al. In vitro optimization of 2'-OMe-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle. Nucleic Acids Res. 2013;41:10659-67 pubmed publisher
    ..Moreover, systemically administrated AMOs to mouse using a liposomal delivery system, YSK05-MEND, showed delivery to the liver and efficient inhibition of miR-122 activity at a low dose in vivo.
  11. Lin Y, Chang P, Chang M, Ni Y. Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Am J Clin Nutr. 2014;99:869-74 pubmed publisher
    ..and protein phosphatase 1 regulatory subunit 3b (PPP1R3B) that were strongly associated with nonalcoholic fatty liver disease (NAFLD) in adults of European ancestry...
  12. Liu H, Qi X, Cao S, Li P. Protective effect of flavonoid extract from Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruit on alcoholic liver oxidative injury in mice. J Nat Med. 2014;68:521-9 pubmed publisher
    ..et Zucc.) flavonoid extract (CBFE) on chronic alcohol-induced liver oxidative injury in mice, experimental mice were pretreated with different doses of CBFE (50-200 mg/kg) for 4 ..
  13. Yin H, Hu M, Liang X, Ajmo J, Li X, Bataller R, et al. Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology. 2014;146:801-11 pubmed publisher
    ..Ethanol exposure disrupts SIRT1 activity and contributes to alcoholic liver disease in rodents, but the exact pathogenic mechanism is not clear...
  14. Spaniel C, Honda M, Selitsky S, Yamane D, Shimakami T, Kaneko S, et al. microRNA-122 abundance in hepatocellular carcinoma and non-tumor liver tissue from Japanese patients with persistent HCV versus HBV infection. PLoS ONE. 2013;8:e76867 pubmed publisher
    ..Despite this, several studies hint at differences in expression of miR-122, a liver-specific microRNA with tumor suppressor properties, in hepatocellular carcinoma (HCC) associated with hepatitis B ..
  15. Itagaki H, Shimizu K, Morikawa S, Ogawa K, Ezaki T. Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice. Int J Clin Exp Pathol. 2013;6:2683-96 pubmed
    Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH), appears to be increasingly common worldwide. Its histopathology and the effects of nutrition on liver function have not been fully determined...
  16. Westra I, Oosterhuis D, Groothuis G, Olinga P. Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs. Toxicol Appl Pharmacol. 2014;274:328-38 pubmed publisher
    Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported...
  17. Markusic D, Hoffman B, Perrin G, Nayak S, Wang X, LoDuca P, et al. Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies. EMBO Mol Med. 2013;5:1698-709 pubmed publisher
    ..Together, these data suggest that hepatic gene transfer-based ITI provides a safe and effective alternative to eradicate inhibitors. This strategy may be broadly applicable to reversal of antibodies in different genetic diseases. ..
  18. Cohen D, Fisher E. Lipoprotein metabolism, dyslipidemia, and nonalcoholic fatty liver disease. Semin Liver Dis. 2013;33:380-8 pubmed publisher
    Cardiovascular disease represents the most common cause of death in patients with nonalcoholic fatty liver disease (NAFLD)...
  19. Ma Y, Li L, Yu C, Shen Z, Chen L, Li Y. Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis. World J Gastroenterol. 2013;19:6911-8 pubmed publisher
    To investigate the relationship between the gut-liver axis and nonalcoholic fatty liver disease (NAFLD), we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD...
  20. Rangel Moreira D, Aoun Tannuri A, Belon A, Mendonça Coelho M, Oliveira Gonçalves J, Serafini S, et al. Large-for-size liver transplantation: a flowmetry study in pigs. J Surg Res. 2014;189:313-20 pubmed publisher
    Ischemia-reperfusion injury is partly responsible for morbidity in pediatric liver transplantation...
  21. Valentine A, Davis C, Tanumihardjo S. Vitamin A isotope dilution predicts liver stores in line with long-term vitamin A intake above the current Recommended Dietary Allowance for young adult women. Am J Clin Nutr. 2013;98:1192-9 pubmed publisher
    ..This intake is presumed to maintain a minimally acceptable liver concentration of 0...
  22. Jenne C, Kubes P. Immune surveillance by the liver. Nat Immunol. 2013;14:996-1006 pubmed publisher
    Receiving both portal vein blood and arterial blood, the liver is an important and critical component in the defense against blood-borne infection...
  23. Zhang X, Xie X, Heckmann B, Saarinen A, Czyzyk T, Liu J. Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Diabetes. 2014;63:934-46 pubmed publisher
    ..Here, we show that upon fasting, G0S2 protein expression exhibits an increase in liver and a decrease in adipose tissue...
  24. Francois S, Mouiseddine M, Allenet Lepage B, Voswinkel J, Douay L, Benderitter M, et al. Human mesenchymal stem cells provide protection against radiation-induced liver injury by antioxidative process, vasculature protection, hepatocyte differentiation, and trophic effects. Biomed Res Int. 2013;2013:151679 pubmed publisher
    To evaluate the potential therapeutic effect of the infusion of hMSCs for the correction of liver injuries, we performed total body radiation exposure of NOD/SCID mice...
  25. Wieser V, Gerner R, Moschen A, Tilg H. Liver complications in inflammatory bowel diseases. Dig Dis. 2013;31:233-8 pubmed publisher
    Diseases of the liver and the biliary tract are commonly observed in patients with inflammatory bowel diseases (IBD)...
  26. Towbin A, Serai S, Podberesky D. Magnetic resonance imaging of the pediatric liver: imaging of steatosis, iron deposition, and fibrosis. Magn Reson Imaging Clin N Am. 2013;21:669-80 pubmed publisher
    Traditionally, many diffuse diseases of the liver could only be diagnosed by liver biopsy. Although still considered the gold standard, liver biopsy is limited by its small sample size, invasive nature, and subjectivity of interpretation...
  27. Rebollo A, Roglans N, Baena M, Sanchez R, Merlos M, Alegret M, et al. Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells. Biochim Biophys Acta. 2014;1841:514-24 pubmed publisher
    ..involved in the inhibition of fatty acid oxidation by fructose and whether this effect occurs also in human liver cells...
  28. Kleiner D, Chalasani N, Lee W, Fontana R, Bonkovsky H, Watkins P, et al. Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations. Hepatology. 2014;59:661-70 pubmed publisher
    Drug-induced liver injury (DILI) is considered to be a diagnosis of exclusion...
  29. Gray B, Mühlhäusler B, Davies P, Vitetta L. Liver enzymes but not free fatty acid levels predict markers of insulin sensitivity in overweight and obese, nondiabetic adults. Nutr Res. 2013;33:781-8 pubmed publisher
    ..markers of insulin sensitivity would be negatively correlated with plasma concentrations of free fatty acids and liver enzymes. Forty nondiabetic adult participants (body mass index ? 25.0 kg/m²) were recruited...
  30. Jakobsdottir G, Xu J, Molin G, Ahrne S, Nyman M. High-fat diet reduces the formation of butyrate, but increases succinate, inflammation, liver fat and cholesterol in rats, while dietary fibre counteracts these effects. PLoS ONE. 2013;8:e80476 pubmed publisher
    ..These effects may be associated with short-chain fatty acids (SCFAs), particularly propionic and butyric acids, formed by microbial degradation of dietary fibres in colon, and by their capacity to reduce low-grade inflammation...
  31. McDaniel K, Herrera L, Zhou T, Francis H, Han Y, Levine P, et al. The functional role of microRNAs in alcoholic liver injury. J Cell Mol Med. 2014;18:197-207 pubmed publisher
    The function of microRNAs (miRNAs) during alcoholic liver disease (ALD) has recently become of great interest in biological research...
  32. Neshat H, Cool D, Barker K, Gardi L, Kakani N, Fenster A. A 3D ultrasound scanning system for image guided liver interventions. Med Phys. 2013;40:112903 pubmed publisher
    ..ultrasound (2D US) imaging is commonly used for diagnostic and intraoperative guidance of interventional liver procedures; however, 2D US lacks volumetric information that may benefit interventional procedures...
  33. Sun P, Zhou X, Farnworth S, Patel A, Hay D. Modeling human liver biology using stem cell-derived hepatocytes. Int J Mol Sci. 2013;14:22011-21 pubmed publisher
    Stem cell-derived hepatocytes represent promising models to study human liver biology and disease. This concise review discusses the recent progresses in the field, with a focus on human liver disease, drug metabolism and virus infection.
  34. Koh M, Takitani K, Miyazaki H, Yamaoka S, Tamai H. Liver X receptor up-regulates ?-tocopherol transfer protein expression and ?-tocopherol status. J Nutr Biochem. 2013;24:2158-67 pubmed publisher
    ..Here, we demonstrate that liver X receptor (LXR) regulates ?-TTP expression through direct interaction with the ?-TTP gene promoter, and it ..
  35. Lagarrigue S, Martin L, Hormozdiari F, Roux P, Pan C, Van Nas A, et al. Analysis of allele-specific expression in mouse liver by RNA-Seq: a comparison with Cis-eQTL identified using genetic linkage. Genetics. 2013;195:1157-66 pubmed publisher
    We report an analysis of allele-specific expression (ASE) and parent-of-origin expression in adult mouse liver using next generation sequencing (RNA-Seq) of reciprocal crosses of heterozygous F1 mice from the parental strains C57BL/6J ..
  36. Kummen M, Schrumpf E, Boberg K. Liver abnormalities in bowel diseases. Best Pract Res Clin Gastroenterol. 2013;27:531-42 pubmed publisher
    b>Liver abnormalities are often seen in bowel diseases. Whether these represent aspects of two separate diseases, or if one is causing the other, is not always easy to decide...
  37. Watson J, Prokopec S, Smith A, Okey A, Pohjanvirta R, Boutros P. TCDD dysregulation of 13 AHR-target genes in rat liver. Toxicol Appl Pharmacol. 2014;274:445-54 pubmed publisher
    ..These data shed new light on the association of the AHR target genes with TCDD toxicity, and in particular the seven genes exhibiting strain-specific differences represent strong candidate mediators of Type-II toxicities. ..
  38. Kudoh K, Uchinami H, Yoshioka M, Seki E, Yamamoto Y. Nrf2 activation protects the liver from ischemia/reperfusion injury in mice. Ann Surg. 2014;260:118-27 pubmed publisher
    ..To investigate the role of Nrf2 in the pathogenesis of hepatic ischemia-reperfusion (I/R) injury...
  39. Yan M, Wang Y, Hu Y, Feng Y, Dai C, Wu J, et al. A high-throughput quantitative approach reveals more small RNA modifications in mouse liver and their correlation with diabetes. Anal Chem. 2013;85:12173-81 pubmed publisher
    ..With this method, we revealed 23 modified nucleosides of tRNA from mouse liver, and 6 of them were observed for the first time in eukaryotic tRNA...
  40. Babeu J, Boudreau F. Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks. World J Gastroenterol. 2014;20:22-30 pubmed publisher
    ..4-alpha (HNF4-?) is a nuclear receptor regulating metabolism, cell junctions, differentiation and proliferation in liver and intestinal epithelial cells...
  41. Verrijken A, Francque S, Mertens I, Prawitt J, Caron S, Hubens G, et al. Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Hepatology. 2014;59:121-9 pubmed publisher
    An independent role of nonalcoholic fatty liver disease (NAFLD) in the development of cardiovascular disease has been suggested, probably mediated through increased levels of prothrombotic factors...
  42. Van den Eede N, Maho W, Erratico C, Neels H, Covaci A. First insights in the metabolism of phosphate flame retardants and plasticizers using human liver fractions. Toxicol Lett. 2013;223:9-15 pubmed publisher
    ..TBOEP, TPHP, TCEP, TCIPP and TDCIPP were incubated with human liver S9 fraction and microsomes...
  43. Leal A, Tannuri A, Belon A, Guimarães R, Coelho M, Oliveira Gonçalves J, et al. A simplified experimental model of large-for-size liver transplantation in pigs. Clinics (Sao Paulo). 2013;68:1152-6 pubmed publisher
    The ideal ratio between liver graft mass and recipient body weight for liver transplantation in small infants is unknown; however, if this ratio is over 4%, a condition called large-for-size may occur...
  44. Donthamsetty S, Bhave V, Mars W, Bowen W, Orr A, Haynes M, et al. Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. PLoS ONE. 2013;8:e74625 pubmed publisher
    ..After a sustained and prolonged proliferation of all epithelial components, proliferation subsided and final liver weight by the end of 30 weeks in livers with PINCH DKO deficient hepatocytes was 40% larger than the control mice...
  45. Guo J, Hirsch S, Streitberger K, Kamphues C, Asbach P, Braun J, et al. Patient-activated three-dimensional multifrequency magnetic resonance elastography for high-resolution mechanical imaging of the liver and spleen. Rofo. 2014;186:260-6 pubmed publisher
    To introduce a novel in-vivo three-dimensional multifrequency magnetic resonance elastography (3D-MMRE) method for high-resolution mechanical characterization of the liver and spleen.
  46. Krawczyk M, Portincasa P, Lammert F. PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease. Semin Liver Dis. 2013;33:369-79 pubmed publisher
    Nonalcoholic fatty liver disease is one of the most common hepatic disorders worldwide...
  47. Nandivada P, Carlson S, Chang M, Cowan E, Gura K, Puder M. Treatment of parenteral nutrition-associated liver disease: the role of lipid emulsions. Adv Nutr. 2013;4:711-7 pubmed publisher
    ..However, long-term parenteral nutrition carries the risk of progressive liver disease...
  48. Nakagawa H, Hikiba Y, Hirata Y, Font Burgada J, Sakamoto K, Hayakawa Y, et al. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014;111:1090-5 pubmed publisher
    E-cadherin is an important adhesion molecule whose loss is associated with progression and poor prognosis of liver cancer. However, it is unclear whether the loss of E-cadherin is a real culprit or a bystander in liver cancer progression...
  49. Rehman K, Iqbal M, Zahra N, Akash M. Liver stem cells: from preface to advancements. Curr Stem Cell Res Ther. 2014;9:10-21 pubmed
    b>Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages...
  50. Ritze Y, Böhle M, Haub S, Hubert A, Enck P, Zipfel S, et al. Role of serotonin in fatty acid-induced non-alcoholic fatty liver disease in mice. BMC Gastroenterol. 2013;13:169 pubmed publisher
    Saturated fatty acids are thought to be of relevance for the development of non-alcoholic fatty liver disease and obesity. However, the underlying mechanisms are poorly understood...
  51. Ruan P, Yang C, Su J, Cao J, Ou C, Luo C, et al. Histopathological changes in the liver of tree shrew (Tupaia belangeri chinensis) persistently infected with hepatitis B virus. Virol J. 2013;10:333 pubmed publisher
    ..We previously established that neonatal tree shrews can be persistently infected with HBV in vivo, and here present a six year follow-up histopathological study of these animals...
  52. Hyysalo J, Gopalacharyulu P, Bian H, Hyötyläinen T, Leivonen M, Jaser N, et al. Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity. Diabetes. 2014;63:312-22 pubmed publisher
    ..compared with noncarriers of PNPLA3(I148M) gene variant display deficiency of TAGs, which accumulate in the liver because of defective lipase activity...
  53. Zhou R, Lin J, Wu D. Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis. Biochim Biophys Acta. 2014;1840:209-18 pubmed publisher
    ..to the ethanol-induced oxidant stress and inhibition of CYP2E1 activity decreases ethanol-induced fatty liver. The transcription factor Nrf2 regulates the expression of many cytoprotective enzymes which results in cellular ..
  54. Sert A, Pirgon O, Aypar E, Yilmaz H, Dundar B. Relationship between aspartate aminotransferase-to-platelet ratio index and carotid intima-media thickness in obese adolescents with non-alcoholic fatty liver disease. J Clin Res Pediatr Endocrinol. 2013;5:182-8 pubmed publisher
    There is increasing evidence for an association between non-alcoholic fatty liver disease (NAFLD) and an increased risk of cardiovascular morbidity and mortality...
  55. Wu S, Pan C. Tolerance and chimerism and allogeneic bone marrow/stem cell transplantation in liver transplantation. World J Gastroenterol. 2013;19:5981-7 pubmed publisher
    The liver has particular tolerogenic properties that allow its spontaneous acceptance in some animal species. Liver structure is considered to favor a tolerogenic environment...
  56. Gougelet A, Torre C, Veber P, Sartor C, Bachelot L, Denechaud P, et al. T-cell factor 4 and ?-catenin chromatin occupancies pattern zonal liver metabolism in mice. Hepatology. 2014;59:2344-57 pubmed publisher
    catenin signaling can be both a physiological and oncogenic pathway in the liver. It controls compartmentalized gene expression, allowing the liver to ensure its essential metabolic function...
  57. Esrefoglu M. Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure. World J Gastroenterol. 2013;19:6757-73 pubmed publisher
    Although the liver has a high regenerative capacity, as a result of massive hepatocyte death, liver failure occurs...
  58. Tang C, Huang H, Lee Y, Tang Y, Wang C. Hepatoprotective effect of mulberry water extracts on ethanol-induced liver injury via anti-inflammation and inhibition of lipogenesis in C57BL/6J mice. Food Chem Toxicol. 2013;62:786-96 pubmed publisher
    ..substances are well recognized for their potential to exert as chemoprotective agents against common alcoholic liver injury...
  59. Shvedova A, Yanamala N, Murray A, Kisin E, Khaliullin T, Hatfield M, et al. Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions. J Toxicol Environ Health A. 2013;76:907-21 pubmed publisher
    ..Here, adverse effects were compared in lungs and liver of BALB/cJ mice after inhalation exposure (0, 50, 150, or 500 ?g/m3; 4 h/d, 5 d/wk, for 4 wk) to CE from 100% ..
  60. Shao C, Chen S, Dong T, Chai H, Yu Y, Deng L, et al. Transplantation of bone marrow-derived mesenchymal stem cells after regional hepatic irradiation ameliorates thioacetamide-induced liver fibrosis in rats. J Surg Res. 2014;186:408-16 pubmed publisher
    Recent studies have demonstrated that bone marrow-derived mesenchymal stem cells (BM-MSCs) can potentially revert liver fibrosis, but it is not known if preparative hepatic irradiation (HIR) contributes to the therapeutic effect of ..
  61. Henao Mejia J, Elinav E, Thaiss C, Licona Limón P, Flavell R. Role of the intestinal microbiome in liver disease. J Autoimmun. 2013;46:66-73 pubmed publisher
    The liver integrates metabolic outcomes with nutrient intake while preventing harmful signals derived from the gut to spread throughout the body...
  62. Cordero P, Campion J, Milagro F, Martinez J. Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: effect of dietary methyl donor supplementation. Mol Genet Metab. 2013;110:388-95 pubmed publisher
    Non-alcoholic fatty liver disease is a primary hepatic manifestation of obesity and an important adverse metabolic syndrome trait...
  63. Pereira H, Leite A, Charone S, Lobo J, Cestari T, Peres Buzalaf C, et al. Proteomic analysis of liver in rats chronically exposed to fluoride. PLoS ONE. 2013;8:e75343 pubmed publisher
    ..b>Liver morphometric analysis did not reveal alterations in the cellular structures and lipid droplets were present in all ..
  64. Liu S, Roberts D, Kharitonenkov A, Zhang B, Hanson S, Li Y, et al. Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue. Sci Rep. 2013;3:2767 pubmed publisher
    ..In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver and adipose tissue...
  65. Abhilash P, Harikrishnan R, Indira M. Ascorbic acid suppresses endotoxemia and NF-?B signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach. Toxicol Appl Pharmacol. 2014;274:215-24 pubmed publisher
    ..The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis...
  66. Jeong H, Kong T, Kwon S, Hong S, Yeon S, Choi J, et al. Effect of honokiol on cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes. Molecules. 2013;18:10681-93 pubmed publisher
    ..2B6, 2C8, 2C9, 2C19, 2D6, and 3A4, and four UDP-glucuronosyltransferases (UGTs) 1A1, 1A4, 1A9, and 2B7 in human liver microsomes were investigated using liquid chromatography-tandem mass spectrometry...
  67. Bellavia M, Rappa F, Lo Bello M, Brecchia G, Tomasello G, Leone A, et al. Lactobacillus casei and bifidobacterium lactis supplementation reduces tissue damage of intestinal mucosa and liver after 2,4,6-trinitrobenzenesulfonic acid treatment in mice. J Biol Regul Homeost Agents. 2014;28:251-61 pubmed
    ..Large bowel (colon and rectum) and liver were processed for histological alterations, according to a scoring system...
  68. Karlsson O, Jiang L, Andersson M, Ilag L, Brittebo E. Protein association of the neurotoxin and non-protein amino acid BMAA (?-N-methylamino-L-alanine) in the liver and brain following neonatal administration in rats. Toxicol Lett. 2014;226:1-5 pubmed publisher
    ..The level of protein-associated BMAA in the liver was more than 10 times higher than that in brain regions not fully protected by the blood-brain barrier which may ..
  69. Pellicoro A, Ramachandran P, Iredale J, Fallowfield J. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol. 2014;14:181-94 pubmed publisher
    ..In this Review, we focus on recent advances in liver fibrosis research as a paradigm for wound healing in solid organs and the role of the immune system in regulating ..
  70. Novo E, Cannito S, Paternostro C, Bocca C, Miglietta A, Parola M. Cellular and molecular mechanisms in liver fibrogenesis. Arch Biochem Biophys. 2014;548:20-37 pubmed publisher
    b>Liver fibrogenesis is a dynamic and highly integrated molecular, tissue and cellular process, potentially reversible, that drives the progression of chronic liver diseases (CLD) towards liver cirrhosis and hepatic failure...
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    ..1 (HMGB1) is an abundant chromatin-associated nuclear protein and released into the extracellular milieu during liver ischemia-reperfusion (I/R), signaling activation of proinflammatory cascades...
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    A hallmark of the nonalcoholic fatty liver disease is the accumulation of lipids. We developed a mathematical model of the hepatic lipid dynamics to simulate the fate of fatty acids in hepatocytes...
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    Although nonalcoholic fatty liver disease (NAFLD) is conventionally assessed histologically for lobular features of inflammation, development of portal fibrosis appears to be associated with disease progression...
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    ..from plant Curcuma longa, on oxidative toxicity, and the possible molecular mechanism of antitumour of curcumin in liver cancer rats...
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    ..We compared the expression of ISGs in the liver and blood of 146 patients with chronic hepatitis C who received pegylated IFN and ribavirin combination therapy...
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    ..presented a 12-fold increase in the blood uptake of (99m)Tc-DTPA and higher bacterial contents in the blood and liver than the control mice...
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    ..The aim of the study was to determine if FPH could influence fatty acid metabolism and inflammation in transgene mice expressing human tumor necrosis factor alpha (hTNF?)...
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    ..However, following a single, oral administration of 1 to beagle dogs, animals experienced an acute liver injury characterized by increases in biomarkers associated with hepatotoxicity; particularly noteworthy was the ..
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    Shark liver oil (SLOil) and fish oil (FOil), which are respectively rich in alkylglycerols (AKGs) and n-3 polyunsaturated fatty acids (PUFAs), are able to reduce the growth of some tumors and the burden of cachexia...
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    ..PCB 136 (2,2',3,3',6,6'-hexachlorobiphenyl), and PCB 149 (2,2',3,4',5',6-hexachlorobiphenyl) to OH-PCBs in liver tissue slices prepared from female mice...
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    ..In mouse embryonic liver, Gata4 is expressed in the endodermal hepatic bud and in the adjacent mesenchyme of the septum transversum...
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    b>Liver sinusoidal endothelial cells (LSECs) are unique organ-resident APCs capable of Ag cross-presentation and subsequent tolerization of naive CD8(+) T cells...
  83. Shukla S, Lim R. Epigenetic effects of ethanol on the liver and gastrointestinal system. Alcohol Res. 2013;35:47-55 pubmed
    ..increasing evidence has firmly established that alcohol modifies several epigenetic parameters in the GI tract and liver. The major pathways affected include DNA methylation, different site-specific modifications in histone proteins, ..
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    ..To test this, we selected AAV2/8, which is emerging as a favored serotype for transduction of liver, muscle, and retina and abundantly found in the extracellular medium...
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    The relationships among micro RNA-122 (miR-122) expression in the liver, hepatitis C virus (HCV) replication and hepatic damage were analyzed in three chimpanzees observed for 180 days after inoculation with HCV genotype 1a...
  86. Aydogan M, Erdogan M, Polat A, Yucel A, Ozgul U, Parlakpinar H, et al. Protective effects of melatonin and ?-d-glucan against liver injury in rats - a comparative study. Adv Clin Exp Med. 2013;22:621-7 pubmed
    ..The aim of this study was to investigate the possible protective effects of melatonin and ?-d-glucan against ischemia-reperfusion (IR) injury in rats...
  87. Liu W, Zheng J, Xing R. Clinical significance of a scoring formula of liver injury for the preoperative evaluation of patients with liver cirrhosis. Eur J Gastroenterol Hepatol. 2014;26:95-100 pubmed publisher
    The aim of this study was to establish a clinical scoring formula of liver injury (SFLI) using the matter element analysis method, in order to provide the necessary information for the preoperative assessment and treatment of liver ..
  88. Wu W, Zhu B, Peng X, Zhou M, Jia D, Gu J. Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease. Biochem Biophys Res Commun. 2014;443:68-73 pubmed publisher
    Alcoholic liver disease (ALD) is a common cause of advanced liver disease, and considered as a major risk factor of morbidity and mortality worldwide. Hepatic cholestasis is a pathophysiological feature observed in all stages of ALD...